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WAKABAYASHI Tomoko  若林 朋子

ORCIDConnect your ORCID iD *help
Researcher Number 20530330
Other IDs
Affiliation (Current) 2025: 明治薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help 2023 – 2025: 明治薬科大学, 薬学部, 准教授
2020 – 2022: 東京大学, 大学院医学系研究科(医学部), 特任准教授
2018 – 2020: 東京大学, 大学院医学系研究科(医学部), 特任助教
2016 – 2017: 東京大学, 大学院医学系研究科(医学部), 助教
2012 – 2015: 東京大学, 医学(系)研究科(研究院), 助教
2014: 東京大学, 大学院医学系研究科, 助教
2009 – 2011: The University of Tokyo, 大学院・医学系研究科, 助教
Review Section/Research Field
Principal Investigator
Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Basic Section 46020:Anatomy and histopathology of nervous system-related / Nerve anatomy/Neuropathology / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / Nerve anatomy/Neuropathology
Except Principal Investigator
Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 52:General internal medicine and related fields / Neurology / Biological Sciences
Keywords
Principal Investigator
アルツハイマー病 / 神経発生 / 運動ニューロン / 脳神経疾患 / コラーゲン / 生活習慣病 / 認知症 / 老化 / 神経筋接合部 / 分子・細胞・神経生物学 … More
Except Principal Investigator
… More アルツハイマー病 / パーキンソン病 / 中枢神経変性疾患 / 極性転換 / ミクログリア / ドコサヘキサエン酸 / 液・液相分離 / 神経変性疾患 / 運動ニューロン疾患 / タウ蓄積症 / 神経変性 / 細胞ストレス / 脳神経疾患 / tau / amyloid beta peptide / タウ / Aβ / マイクロダイアリシス / βアミロイド / アルツハイマー / 神経活動 / アミロイド / 光遺伝学 / シナプス / アミロイドβペプチド Less
  • Research Projects

    (11 results)
  • Research Products

    (32 results)
  • Co-Researchers

    (7 People)
  •  老化依存的な脳異常タンパク質蓄積の末梢-脳連関を介した制御とメカニズムの解明Principal Investigator

    • Principal Investigator
      若林 朋子
    • Project Period (FY)
      2025 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Meiji Pharmaceutical University
  •  Investigation of the effect of docosahexaenoic acid on preventing the onset and progression of Parkinson's disease

    • Principal Investigator
      蒲生 修治
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Meiji Pharmaceutical University
  •  認知症の病態を末梢から制御する老化・生活習慣関連因子の探索Principal Investigator

    • Principal Investigator
      若林 朋子
    • Project Period (FY)
      2023 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
    • Research Institution
      Meiji Pharmaceutical University
  •  Molecular basis of axon elongation by collagen XXV and pathomechanisms of congenital cranial dysinnervation disordersPrincipal Investigator

    • Principal Investigator
      Wakabayashi Tomoko
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 46020:Anatomy and histopathology of nervous system-related
    • Research Institution
      The University of Tokyo
  •  Stress dependent production and release of aggregated proteins in neurodegenerative disorders

    • Principal Investigator
      Iwatsubo Takeshi
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      The University of Tokyo
  •  Molecular bases of collagen XXV functions in neurological diseases and healthy aging.Principal Investigator

    • Principal Investigator
      Wakabayashi Tomoko
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      The University of Tokyo
  •  Elucidation of the molecular mechanisms of Abeta economy in the brain of Alzheimer's disease

    • Principal Investigator
      Iwatsubo Takeshi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      The University of Tokyo
  •  The elucidation of functions of CLAC-P/collagen XXV in neuromuscular development and synapse formationPrincipal Investigator

    • Principal Investigator
      Wakabayashi Tomoko
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      The University of Tokyo
  •  Physiological functions of CLAC-P/Col XXV in axon elongation and synapse formationPrincipal Investigator

    • Principal Investigator
      WAKABAYASHI Tomoko
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      The University of Tokyo
  •  Elucidation of the molecular pathology of Alzheimer's disease focusing on the synapses toward therapies

    • Principal Investigator
      IWATSUBO Takeshi
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Analysis of the gamma-secretase interactome and regulation mechanisms of the enzymatic activity.Principal Investigator

    • Principal Investigator
      WAKABAYASHI Tomoko
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2016 2015 2014 2013 2012 2009 Other

All Journal Article Presentation Book

  • [Book] 医学のあゆみ2023

    • Author(s)
      若林 朋子
    • Total Pages
      5
    • Publisher
      医歯薬出版株式会社
    • Data Source
      KAKENHI-PROJECT-23K18416
  • [Book] Dementia Japan2023

    • Author(s)
      若林 朋子
    • Total Pages
      7
    • Publisher
      日本認知症学会
    • Data Source
      KAKENHI-PROJECT-23K18416
  • [Journal Article] Genetic reduction of insulin signaling mitigates amyloid-β deposition by promoting expression of extracellular matrix proteins in the brain2023

    • Author(s)
      Sano T, Ochiai T, Nagayama T, Nakamura A, Kubota N, Kadowaki T, Wakabayashi T, Iwatsubo T
    • Journal Title

      Journal of Neuroscience

      Volume: 43 Issue: 43 Pages: 7226-7241

    • DOI

      10.1523/jneurosci.0071-23.2023

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K18416
  • [Journal Article] Casein kinase 1δ/ε phosphorylates fused in sarcoma (FUS) and ameliorates FUS-mediated neurodegeneration2022

    • Author(s)
      Kishino Yuya、Matsukawa Koji、Matsumoto Taisei、Miyazaki Ryota、Wakabayashi Tomoko、Nonaka Takashi、Kametani Fuyuki、Hasegawa Masato、Hashimoto Tadafumi、Iwatsubo Takeshi
    • Journal Title

      Journal of Biological Chemistry

      Volume: 298 Issue: 8 Pages: 102191-102191

    • DOI

      10.1016/j.jbc.2022.102191

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07270, KAKENHI-PROJECT-22K07362, KAKENHI-PROJECT-20H00525, KAKENHI-PROJECT-22KJ0792
  • [Journal Article] Transmembrane Collagens in Neuromuscular Development and Disorders2021

    • Author(s)
      Wakabayashi Tomoko
    • Journal Title

      Frontiers in Molecular Neuroscience

      Volume: 13 Pages: 635375-635375

    • DOI

      10.3389/fnmol.2020.635375

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K06888
  • [Journal Article] Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects of their deficiency on amyloid pathology in Alzheimer's disease.2021

    • Author(s)
      Ochiai T, Sano T, Kubota N, Kadowaki T, Wakabayashi T, Iwatsubo T
    • Journal Title

      Neurobiology of Disease

      Volume: 159 Pages: 105510-105510

    • DOI

      10.1016/j.nbd.2021.105510

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H00525
  • [Journal Article] Tauroursodeoxycholic acid attenuates diet-induced and age-related peripheral endoplasmic reticulum stress and cerebral amyloid pathology in a mouse model of Alzheimer’s disease.2021

    • Author(s)
      Ochiai T, Nagayama T, Matsui K, Amano K, Sano T, Wakabayashi T, Iwatsubo T
    • Journal Title

      J Prev Alzheimers Dis

      Volume: 4 Issue: 4 Pages: 483-494

    • DOI

      10.14283/jpad.2021.33

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H00525
  • [Journal Article] Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques2020

    • Author(s)
      Hashimoto Tadafumi、Fujii Daisuke、Naka Yasushi、Kashiwagi-Hakozaki Mayu、Matsuo Yuko、Matsuura Yusuke、Wakabayashi Tomoko、Iwatsubo Takeshi
    • Journal Title

      Acta Neuropathologica Communications

      Volume: 8 Issue: 1 Pages: 212-212

    • DOI

      10.1186/s40478-020-01075-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07364, KAKENHI-PROJECT-20H00525, KAKENHI-PROJECT-19J12600
  • [Journal Article] Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease2019

    • Author(s)
      Tomoko Wakabayashi, Kazuki Yamaguchi, Kentaro Matsui, Toshiharu Sano, Tetsuya Kubota, Tadafumi Hashimoto, Ayako Mano, Kaoru Yamada, Yuko Matsuo, Naoto Kubota, Takashi Kadowaki, Takeshi Iwatsubo
    • Journal Title

      Molecular Neurodegeneration

      Volume: 14 Issue: 1 Pages: 15-15

    • DOI

      10.1186/s13024-019-0315-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07364, KAKENHI-PROJECT-19K08991, KAKENHI-PROJECT-19H01052, KAKENHI-PROJECT-26000012, KAKENHI-PROJECT-17H04193, KAKENHI-PROJECT-18H02860
  • [Journal Article] Collagen XXV promotes myoblast fusion during myogenic differentiation and muscle formation2019

    • Author(s)
      Goncalves T.J.M, Boutillon F, Lefebvre S, Goffin V, Iwatsubo T, Wakabayashi T, Oury F, Armand A-S
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 5878-5878

    • DOI

      10.1038/s41598-019-42296-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07091
  • [Journal Article] Roles of collagen XXV and its putative receptors PTP s/d in intramuscular motor innervation and congenital cranial dysinnervation disorder2019

    • Author(s)
      Haruka Munezane, Hiroaki Oizumi, Tomoko Wakabayashi, Shu Nishio, Tomoko Hirasawa, Takashi Sato, Akihiro Harada, Tomoyuki Yoshida, Takahiro Eguchi, Yuji Yamanashi, Tadafumi Hashimoto, Takeshi Iwatsubo
    • Journal Title

      Cell Reports

      Volume: 29 Issue: 13 Pages: 4362-4376

    • DOI

      10.1016/j.celrep.2019.11.112

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07364, KAKENHI-PROJECT-19K06435, KAKENHI-ORGANIZER-17H06413, KAKENHI-PUBLICLY-19H04744, KAKENHI-PROJECT-17K07091, KAKENHI-PROJECT-17H01532, KAKENHI-PROJECT-17H04193
  • [Journal Article] Chronic optogenetic activation augments Aβ pathology in a mouse model of Alzheimer disease2015

    • Author(s)
      Kaoru Yamamoto, Zen-ichi Tanei, Tadafumi Hashimoto, Tomoko Wakabayashi, Hiroyuki Okuno, Yasushi Naka, Ofer Yizhar, Lief E. Fenno, Masashi Fukayama, Haruhiko Bito, John R. Cirrito, David M. Holtzman, Karl Deisseroth, Takeshi Iwatsubo
    • Journal Title

      Cell reports

      Volume: 11 Issue: 6 Pages: 859-865

    • DOI

      10.1016/j.celrep.2015.04.017

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-22110003, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-15K08297, KAKENHI-PROJECT-15H02358
  • [Journal Article] CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development.2014

    • Author(s)
      Tanaka T, Wakabayashi T, Oizumi H, Nishio S, Sato T, Harada A, Fujii D, Matsuo Y, Hashimoto T, Iwatsubo T.
    • Journal Title

      J Neurosci.

      Volume: 34 Issue: 4 Pages: 1370-1379

    • DOI

      10.1523/jneurosci.2440-13.2014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591347, KAKENHI-PROJECT-24390046, KAKENHI-PROJECT-24659084, KAKENHI-PROJECT-24700373, KAKENHI-PROJECT-24800015, KAKENHI-PUBLICLY-25113517
  • [Journal Article] Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains2009

    • Author(s)
      若林朋子
    • Journal Title

      Nature Cell Biology 11

      Pages: 1340-1346

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21700392
  • [Journal Article] Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains.2009

    • Author(s)
      Wakabayashi T, Craessaerts K, Bammens L, Bentahir M, Borgions F, Herdewijn P, Staes A, Timmerman E, Vandekerckhove J, Rubinstein E, Boucheix C, Gevaert K, De Strooper B.
    • Journal Title

      Nature Cell Biology 11

      Pages: 1340-1346

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21700392
  • [Presentation] 認知症の危険因子としての糖尿病とその病態メカニズム2023

    • Author(s)
      若林朋子
    • Organizer
      第42回 日本認知症学会集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K18416
  • [Presentation] 末梢組織のNAD+代謝の変化が脳のアミロイドβ蓄積に及ぼす影響の解析2023

    • Author(s)
      中村文香、若林朋子、岩坪威
    • Organizer
      第42回 日本認知症学会集会
    • Data Source
      KAKENHI-PROJECT-23K18416
  • [Presentation] Diabetes as a risk factor for Alzheimer's disease2023

    • Author(s)
      Tomoko Wakabayashi
    • Organizer
      第97回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-23K18416
  • [Presentation] Roles of collagen XXV in motor innervation of skeletal muscle and the development of a congenital cranial dysinnervation disorder2020

    • Author(s)
      Tomoko Wakabayashi, Takeshi Iwatsubo
    • Organizer
      第43回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K06888
  • [Presentation] 神経-筋発生におけるcollagen XXVの発現制御機構の解析2019

    • Author(s)
      平澤朋子、若林朋子、岩坪威
    • Organizer
      第38回 日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K07091
  • [Presentation] CLAC-P/collagen type XXV regulates intramuscular innervation of motor axons through the interaction with receptor protein tyrosine phosphatase σ and δ2018

    • Author(s)
      Munezane H,Oizumi H, Yoshida T, Wakabayashi T, Iwatsubo T
    • Organizer
      日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-17K07091
  • [Presentation] Identification of the interactor of CLAC-P/Collagen type XXV in motor nerve innervation of skeletal muscles2016

    • Author(s)
      Haruka Munezane, Hiroaki Oizumi, Tomoyuki Yoshida, Tomoko Wakabayashi, Takeshi Iwastubo
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      San Diego, CA (U.S.A.)
    • Year and Date
      2016-11-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26430064
  • [Presentation] The elucidation of the physiological function of CLAC-P/ collagen XXV in neuromuscular development2016

    • Author(s)
      Haruka Munezane, Hiroaki Oizumi, Tomoyuki Yoshida, Tomoko Wakabayashi, Takeshi Iwastubo
    • Organizer
      The 47th NIPS International Symposium
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県岡崎市)
    • Year and Date
      2016-10-27
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26430064
  • [Presentation] Roles in Neuromuscular Development of CLAC-P/Collagen Type XXV: A Molecule Originally Identified in Alzheimer Brains2015

    • Author(s)
      Tomoko Wakabayashi
    • Organizer
      Gordon Research Conference: Collagen
    • Place of Presentation
      New London, NH ( U.S.A.)
    • Year and Date
      2015-07-12
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26430064
  • [Presentation] The elucidation of molecular mechanism of CLAC-P/Collagen type XXV in motor innervation of skeletal muscle2015

    • Author(s)
      Haruka Munezane, Hiroaki Oizumi, Tomoyuki Yoshida, Tomoko Wakabayashi, Takeshi Iwastubo
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-26430064
  • [Presentation] Collagen XXV/CLAC-Pの骨格筋における発現制御に関する研究2015

    • Author(s)
      西尾 周、大泉 寛明、宗實 悠佳、若林 朋子、岩坪 威
    • Organizer
      第34回 日本認知症学会学術集会
    • Place of Presentation
      リンクステーションホール青森(青森県青森市)
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PROJECT-26430064
  • [Presentation] ROLE OF CLAC-P/TYPE XXV COLLAGEN IN THE TERMINAL ARBORIZATION AND SURVIVAL OF DEVELOPING MOTONEURONS2013

    • Author(s)
      若林朋子
    • Organizer
      The 11th International Conference on Alzheimer's & Parkinson's Diseases
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2013-03-07
    • Data Source
      KAKENHI-PROJECT-24700373
  • [Presentation] オプとジェネティックスを用いた神経活動依存的なAβ分泌・蓄積の検討2012

    • Author(s)
      山本薫、奥野浩行、尾藤晴彦、若林朋子、橋本唯史、岩坪威
    • Organizer
      第31回 日本認知症学会
    • Place of Presentation
      筑波市
    • Invited
    • Data Source
      KAKENHI-PLANNED-22110003
  • [Presentation] Biochemical analysis of gamma-secretase interacting proteins and its effects on the gamma-secretase activity2009

    • Author(s)
      Wakabayashi T
    • Organizer
      Society for Neuroscience 2009
    • Place of Presentation
      米国・シカゴ
    • Year and Date
      2009-10-21
    • Data Source
      KAKENHI-PROJECT-21700392
  • [Presentation] CLAC-P/collagen type XXV in muscle, but not in motor neurons, is required for intramuscular development of motor axons

    • Author(s)
      Oizumi H, Tanaka T, Nishio S, Munezane H, Hashimoto T, Harada A, Wakabayashi T, Iwatsubo T
    • Organizer
      Society for Neuroscience 2014
    • Place of Presentation
      Washington DC, U.S.A.
    • Year and Date
      2014-11-15 – 2014-11-19
    • Data Source
      KAKENHI-PROJECT-26430064
  • [Presentation] ROLE OF CLAC-P/TYPE XXV COLLAGEN IN THE TERMINAL ARBORIZATION AND SURVIVAL OF DEVELOPING MOTONEURONS

    • Author(s)
      Tomoko Wakabayashi
    • Organizer
      The 11th International Conference on Alzheimer's & Parkinson's Diseases
    • Place of Presentation
      Florence, Italy
    • Data Source
      KAKENHI-PROJECT-24700373
  • [Presentation] アルツハイマー病脳老人斑構成成分 CLAC-P/CollagenXXV の 中枢神経系における生理機能の解明

    • Author(s)
      宗実悠佳、吉田知之、若林朋子、岩坪威
    • Organizer
      第33回日本認知症学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-29 – 2014-12-01
    • Data Source
      KAKENHI-PROJECT-26430064
  • 1.  IWATSUBO Takeshi (50223409)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 2.  HASHIMOTO Tadafumi (30334337)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 6 results
  • 3.  山田 薫 (00735152)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  ITO Genta (10431892)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  桑原 知樹 (10533903)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  蒲生 修治 (20273930)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  佐藤 隆史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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