HATORI Akiko 羽鳥晶子

Researcher Number	20531528
Affiliation (based on the past Project Information) *help	2019 – 2020: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所先進核医学基盤研究部, 主幹研究員(任非) 2017 – 2018: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所標識薬剤開発部, 主幹研究員(任非)
Review Section/Research Field	Principal Investigator Radiation science Except Principal Investigator Radiation science
Keywords	Principal Investigator 画像化 / ポジトロン　エミッション　トモグラフィー / PETプローブ / PET / ポジトロン　エミッション　トモグラフィ / MAGL / モノアシルグリセロールリパーゼ Except Principal Investigator 画像化 / [11C]DMTN / オートラジオグラフィ … More / 代謝型グルタミン酸受容体サブタイプ２ / PETプローブ / mGluR2 / 代謝型グルタミン酸受容体 / 分子イメージング / PET Less

Visualization of monoacylglycerol lipase in ischemia rat brain using [11C]SAR127303 and development of new PET probes.Principal Investigator
- Principal Investigator
  
  HATORI Akiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Development of novel PET probes for imaging of metabotropic glutamate receptor subtype 2
- Principal Investigator
  
  Zhang Ming-Rong
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology

All 2019 2018 2017

All Journal Article Presentation

[Journal Article] Radiosynthesis and evaluation of a novel monoacylglycerol lipase radiotracer: 1,1,1,3,3,3-hexafluoropropan-2-yl-3-(1-benzyl-1H-pyrazol-3-yl)azetidine-1-[11C]carboxylate2019
- Author(s)
  Mori Wakana、Hatori Akiko、Zhang Yiding、Kurihara Yusuke、Yamasaki Tomoteru、Xie Lin、Kumata Katsushi、Hu Kuan、Fujinaga Masayuki、Zhang Ming-Rong
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Issue: 16 Pages: 3568-3573
- DOI
  10.1016/j.bmc.2019.06.037
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17156, KAKENHI-PROJECT-17H04267, KAKENHI-PROJECT-17K10461, KAKENHI-PROJECT-17K16495
[Journal Article] Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a “Tail Switching” Strategy on a Piperazinyl Azetidine Skeleton2019
- Author(s)
  Chen Zhen、Mori Wakana、Deng Xiaoyun、Cheng Ran、Ogasawara Daisuke、Zhang Genwei、Schafroth Michael A.、Dahl Kenneth、Fu Hualong、Hatori Akiko、Shao Tuo、Zhang Yiding、Yamasaki Tomoteru、Zhang Xiaofei、Rong Jian、Yu Qingzhen、Hu Kuan、Fujinaga Masayuki、Xie Lin、Kumata Katsushi、Gou Yuancheng、Chen Jingjin、Gu Shuyin
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 62 Issue: 7 Pages: 3336-3353
- DOI
  10.1021/acs.jmedchem.8b01778
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10461, KAKENHI-PROJECT-18H06217, KAKENHI-PROJECT-17H04267, KAKENHI-PROJECT-17K16495
[Journal Article] Synthesis and evaluation of 4-(2-fluoro-4-[11C]methoxyphenyl)-5-((2-methylpyridin-4-yl)methoxy)picolinamide for PET imaging of the metabotropic glutamate receptor 2 in the rat brain2019
- Author(s)
  Kumata Katsushi、Hatori Akiko、Yamasaki Tomoteru、Zhang Yiding、Mori Wakana、Fujinaga Masayuki、Xie Lin、Nengaki Nobuki、Zhang Ming-Rong
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Issue: 3 Pages: 483-491
- DOI
  10.1016/j.bmc.2018.12.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04267
[Journal Article] Design, Synthesis, and Evaluation of 18F-Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes2019
- Author(s)
  Chen Zhen, Mori Wakana, Zhang Ming-Rong, Liang Steven H. et al
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 62 Issue: 19 Pages: 8866-8872
- DOI
  10.1021/acs.jmedchem.9b00936
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04267, KAKENHI-PROJECT-17K10461
[Journal Article] In Vitro and in Vivo Evaluation of 11C-Labeled Azetidinecarboxylates for Imaging Monoacylglycerol Lipase by PET Imaging Studies2018
- Author(s)
  Ran Cheng, Wakana Mori, Longle Ma, Mireille Alhouayek, Akiko Hatori, Yiding Zhang, Daisuke Ogasawara, Gengyang Yuan, Zhen Chen, Xiaofei Zhang, Hang Shi, Tomoteru Yamasaki, Lin Xie, Katsushi Kumata, Masayuki Fujinaga, Yuji Nagai, Takafumi Minamimoto, Mona Svensson, Lu Wang, Yunfei Du, Mary Jo Ondrechen, Neil Vasdev
- Journal Title
  
  J. Med. Chem.
  
  Volume: 61 Issue: 6 Pages: 2278-2291
- DOI
  10.1021/acs.jmedchem.7b01400
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10461, KAKENHI-PLANNED-15H05917
[Journal Article] Development of 2-(2-(3-(4-([18F]Fluoromethoxy-d2)phenyl)-7-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)-4-isopropoxyisoindoline-1,3-dione for Positron-Emission-Tomography Imaging of Phosphodiesterase 10A in the Brain2018
- Author(s)
  Mori Wakana、Yamasaki Tomoteru、Fujinaga Masayuki、Ogawa Masanao、Zhang Yiding、Hatori Akiko、Xie Lin、Kumata Katsushi、Wakizaka Hidekatsu、Kurihara Yusuke、Ohkubo Takayuki、Nengaki Nobuki、Zhang Ming-Rong
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 62 Issue: 2 Pages: 688-698
- DOI
  10.1021/acs.jmedchem.8b01366
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04267
[Journal Article] Synthesis of two novel [18F]fluorobenzene-containing radiotracers via spirocyclic iodonium ylides and positron emission tomography imaging of translocator protein (18 kDa) in ischemic brain2018
- Author(s)
  Fujinaga Masayuki、Kumata Katsushi、Zhang Yiding、Hatori Akiko、Yamasaki Tomoteru、Mori Wakana、Ohkubo Takayuki、Xie Lin、Nengaki Nobuki、Zhang Ming-Rong
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 16 Issue: 37 Pages: 8325-8335
- DOI
  10.1039/c8ob01700j
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16495, KAKENHI-PROJECT-17H04267
[Journal Article] [18F]DAA1106: Automated radiosynthesis using spirocyclic iodonium ylide and preclinical evaluation for positron emission tomography imaging of translocator protein (18?kDa)2018
- Author(s)
  Kumata Katsushi、Zhang Yiding、Fujinaga Masayuki、Ohkubo Takayuki、Mori Wakana、Yamasaki Tomoteru、Hanyu Masayuki、Xie Lin、Hatori Akiko、Zhang Ming-Rong
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 26 Issue: 17 Pages: 4817-4822
- DOI
  10.1016/j.bmc.2018.08.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16495, KAKENHI-PROJECT-17H04267
[Journal Article] First demonstration of in vivo mapping for regional brain monoacylglycerol lipase using PET with [ 11 C]SAR1273032018
- Author(s)
  Yamasaki Tomoteru、Mori Wakana、Zhang Yiding、Hatori Akiko、Fujinaga Masayuki、Wakizaka Hidekatsu、Kurihara Yusuke、Wang Lu、Nengaki Nobuki、Ohya Tomoyuki、Liang Steven H.、Zhang Ming-Rong
- Journal Title
  
  NeuroImage
  
  Volume: 176 Pages: 313-320
- DOI
  10.1016/j.neuroimage.2018.05.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19870, KAKENHI-PROJECT-17K10461
[Journal Article] First demonstration of in vivo mapping for regional brain monoacylglycerol lipase using PET with [11C]SAR1273032018
- Author(s)
  Tomoteru Yamasaki, Wakana Mori, Yiding Zhang, Akiko Hatori, Masayuki Fujinaga, Hidekatsu Wakizaka, Yusuke Kurihara, Lu Wang, Nobuki Nengaki, Tomoyuki Ohya, Steven H Liang, Ming-Rong Zhang
- Journal Title
  
  NeuroImage
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10461
[Journal Article] Synthesis and evaluation of 1-(cyclopropylmethyl)-4-(4-[ 11 C]methoxyphenyl)-piperidin-1-yl-2-oxo-1,2-dihydropyridine-3-carbonitrile ([ 11 C]CMDC) for PET imaging of metabotropic glutamate receptor 2 in the rat brain2017
- Author(s)
  Ma Yufei、Kumata Katsushi、Yui Joji、Zhang Yiding、Yamasaki Tomoteru、Hatori Akiko、Fujinaga Masayuki、Nengaki Nobuki、Xie Lin、Wang Hui、Zhang Ming-Rong
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 25 Issue: 3 Pages: 1014-1021
- DOI
  10.1016/j.bmc.2016.12.011
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04267
[Journal Article] Synthesis and in vitro evaluation of three novel radiotracers for imaging of metabotropic glutamate receptor subtype 2 in rat brain2017
- Author(s)
  Kumata Katsushi、Yamasaki Tomoteru、Hatori Akiko、Zhang Yiding、Mori Wakana、Fujinaga Masayuki、Xie Lin、Okubo Takayuki、Nengaki Nobuki、Zhang Ming-Rong
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 27 Issue: 14 Pages: 3139-3143
- DOI
  10.1016/j.bmcl.2017.05.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04267
[Journal Article] Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[11C]methoxyphenyl) quinoline-2-carboxamide, for Imaging of Metabotropic Glutamate Receptor 22017
- Author(s)
  Zhang Xiaofei、Kumata Katsushi、Yamasaki Tomoteru、Cheng Ran、Hatori Akiko、Ma Longle、Zhang Yiding、Xie Lin、Wang Lu、Kang Hye Jin、Sheffler Douglas J.、Cosford Nicholas D. P.、Zhang Ming-Rong、Liang Steven H.
- Journal Title
  
  ACS Chemical Neuroscience
  
  Volume: 8 Issue: 9 Pages: 1937-1948
- DOI
  10.1021/acschemneuro.7b00098
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04267
[Presentation] Radiosynthesis and evaluation of a negative allosteric modulator for the PET imaging of metabotropic glutamate receptor 2 in rat brain2019
- Author(s)
  Kumata K, Zhang Y, Hatori A, Yamasaki T, Kurihara Y, Nengaki N, Zhang MR
- Organizer
  The 23nd International symposium on radiopharmaceutical science (ISRS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04267
[Presentation] 代謝型グルタミン酸受容体2に選択的な新規[11C]標識PETリガンドの合成と評価2019
- Author(s)
  熊田勝志, 山崎友照, 張一鼎, 森若菜, 藤永雅之, 羽鳥晶子, 念垣信樹, 張明栄
- Organizer
  第59回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04267
[Presentation] Monoacylglycerol lipaseのPETプローブ[18F]PF06795071の評価2019
- Author(s)
  羽鳥　晶子、森　若菜、張　一鼎、藤永　雅之、張　明栄
- Organizer
  第59回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-17K10461
[Presentation] Synthesis and evaluation of a new PET ligand for imaging of monoacylglycerol lipase in brain2019
- Author(s)
  Mori W, Kurihara Y, Hatori A, Zhang Y, Fujinaga M, Zhang MR
- Organizer
  The 23nd International symposium on radiopharmaceutical science (ISRS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04267
[Presentation] [11C]で標識したMAGLに選択的な新規PETリガンドの合成及び動物評価2019
- Author(s)
  森　若菜, 栗原　雄祐, 羽鳥　晶子, 張　一鼎, 藤永　雅之, 張　明栄
- Organizer
  第59回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-17K10461
[Presentation] Visualization of MAGL in ischemia rat brain using PET probe 11C-SAR1273032019
- Author(s)
  Akiko Hatori, Yiding Zhang, Wakana Mori, Yusuke Kurihara, Hidekatsu Wakisaka, Ming-Rong Zhang
- Organizer
  Brain & Brain PET 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10461
[Presentation] 代謝型グルタミン酸受容体2に選択的な新規11C-標識PETリガンドの合成と評価2018
- Author(s)
  熊田勝志、山崎友照、張一鼎、森若菜、羽鳥晶子、藤永雅之、念垣信樹、張明栄
- Organizer
  第58回日本核医学会総会
- Data Source
  KAKENHI-PROJECT-17H04267
[Presentation] 脳虚血モデルラットを用いたPETプローブ[11C]SAR1による脳内MAGLの画像化2018
- Author(s)
  羽鳥　晶子、張　一鼎、森　若菜、栗原　雄祐、脇坂　秀克、張　明栄
- Organizer
  日本核医学会
- Data Source
  KAKENHI-PROJECT-17K10461
[Presentation] Development and radiotherapeutic effect of two novel I-131 or At-211 labelled radioprobes for melanoma with overexpressed metabotropic glutamate receptor 12018
- Author(s)
  Masayuki Hanyu, Lin Xie, Masayuki Fujinaga, Yiding Zhang, Akiko Hatori, Yukie Morokoshi, Huizi Li, Katsuyuki Minegishi, Sumitaka Hasegawa, Kotaro Nagatsu, Ming-Rong Zhang
- Organizer
  12th Congress of the World federation of Nuclear Medicine and Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04267
[Presentation] Development of new radioprobes for PET imaging of metabotropic glutamate receptor subtype 2 in rat brain2017
- Author(s)
  Katsushi Kumata, Tomoteru Yamasaki, Yiding Zhang, Akiko Hatori, Wakana Mori, Masayuki Fujinaga, Ming-Rong Zhang
- Organizer
  SNMMI 2017Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04267
[Presentation] Development of [11C]CMDC for PET imaging of metabotropic glutamate receptor 2 in the rat brain2017
- Author(s)
  Katsushi Kumata, Yiding Zhang, Akiko Hatori, Tomoteru Yamasaki, Takayuki Ohkubo, Yusuke Kurihara, Masayuki Fujinaga, Lin Xie, Kazunori Kawamura, Ming-Rong Zhang
- Organizer
  22nd International symposium on radiopharmaceutical science (ISRS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04267
[Presentation] 新規代謝型グルタミン酸２型受容体選択的PETリガンドの合成と評価2017
- Author(s)
  熊田勝志, 山崎友照, 張一鼎, 羽鳥　晶子, 藤永　雅之, 念垣　信樹, 張　明栄
- Organizer
  第57回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04267

1. Zhang Ming-Rong (80443076)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
2. 謝琳 (30623558)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
3. 藤永雅之 (70623726)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
4. 山崎友照 (80627563)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
5. 河村和紀 (50401766)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 胡寛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HATORI Akiko 羽鳥 晶子

Research Projects

Research Products

Co-Researchers

Visualization of monoacylglycerol lipase in ischemia rat brain using [11C]SAR127303 and development of new PET probes.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel PET probes for imaging of metabotropic glutamate receptor subtype 2

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Radiosynthesis and evaluation of a novel monoacylglycerol lipase radiotracer: 1,1,1,3,3,3-hexafluoropropan-2-yl-3-(1-benzyl-1H-pyrazol-3-yl)azetidine-1-[11C]carboxylate2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a “Tail Switching” Strategy on a Piperazinyl Azetidine Skeleton2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis and evaluation of 4-(2-fluoro-4-[11C]methoxyphenyl)-5-((2-methylpyridin-4-yl)methoxy)picolinamide for PET imaging of the metabotropic glutamate receptor 2 in the rat brain2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Design, Synthesis, and Evaluation of 18F-Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In Vitro and in Vivo Evaluation of 11C-Labeled Azetidinecarboxylates for Imaging Monoacylglycerol Lipase by PET Imaging Studies2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of 2-(2-(3-(4-([18F]Fluoromethoxy-d2)phenyl)-7-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)-4-isopropoxyisoindoline-1,3-dione for Positron-Emission-Tomography Imaging of Phosphodiesterase 10A in the Brain2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of two novel [18F]fluorobenzene-containing radiotracers via spirocyclic iodonium ylides and positron emission tomography imaging of translocator protein (18 kDa) in ischemic brain2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] [18F]DAA1106: Automated radiosynthesis using spirocyclic iodonium ylide and preclinical evaluation for positron emission tomography imaging of translocator protein (18?kDa)2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] First demonstration of in vivo mapping for regional brain monoacylglycerol lipase using PET with [ 11 C]SAR1273032018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] First demonstration of in vivo mapping for regional brain monoacylglycerol lipase using PET with [11C]SAR1273032018

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis and evaluation of 1-(cyclopropylmethyl)-4-(4-[ 11 C]methoxyphenyl)-piperidin-1-yl-2-oxo-1,2-dihydropyridine-3-carbonitrile ([ 11 C]CMDC) for PET imaging of metabotropic glutamate receptor 2 in the rat brain2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis and in vitro evaluation of three novel radiotracers for imaging of metabotropic glutamate receptor subtype 2 in rat brain2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[11C]methoxyphenyl) quinoline-2-carboxamide, for Imaging of Metabotropic Glutamate Receptor 22017

Author(s)

Journal Title

DOI

Data Source

HATORI Akiko 羽鳥晶子