SASAKI TSUTOMU 佐々木勉

… Alternative Names

SASAKI Tsutomu 佐々木勉

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Researcher Number	20534879
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 特任教授(常勤)
Affiliation (based on the past Project Information) *help	2023 – 2024: 大阪大学, 大学院医学系研究科, 特任教授(常勤) 2022 – 2023: 大阪大学, 大学院医学系研究科, 寄附講座准教授 2022: 大阪大学, 大学院医学系研究科, 特任教授 2020 – 2021: 大阪大学, 医学系研究科, 寄附講座准教授 2017 – 2019: 大阪大学, 医学系研究科, 講師 2010 – 2016: 大阪大学, 医学部附属病院, 助教 2009: Osaka University, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Neurology / Basic Section 52020:Neurology-related / Applied pharmacology Except Principal Investigator Basic Section 38050:Food sciences-related / Medium-sized Section 38:Agricultural chemistry and related fields / Epidemiology and preventive medicine / Food science / Neurology
Keywords	Principal Investigator 脳虚血 / 血液脳関門 / 血管内皮細胞 / 低分子化合物 / パーキンソン病 / CREB / occludin / claudin / 脳梗塞 / アストロサイト … More / 神経病態 / クロ―ディン / オクルディン / クローディン / グリア細胞 / タイトジャンクション / トランスレーショナルリサーチ / 創薬化学 / 蛋白蛋白相互作用 / 蛋白質 / 脳神経疾患 / 神経保護剤 / 蛋白相互作用阻害剤 / 血管内皮 / 神経細胞 / MDMX / MDM2 / p53 / PPI阻害剤 / 脳卒中 / 神経疾患 / TORC / エピゲノム / アポトーシス / HDAC / SIK（塩誘導性キナーゼ） / CRTC / 創薬 / ＨＤＡＣ阻害剤 / ＨＤＡＣ（ヒストン脱アセチル化酵素） / ＳＩＫ（塩誘導性キナーゼ） / ＣＲＥＢ / シグナルトランスダクション / 虚血耐性 / NDMA受容 / TORC1 / α7 nchR / サブタイプ / NDMA受容体 / SIK2 / TORC1/ CRTC1 / NR2B / NR2A / NMDA受容体 … More Except Principal Investigator 転写因子 / 油脂 / 肥満 / 高脂肪食 / 嗜好性 / 糖尿病 / cAMP / 神経 / 過食 / 油脂摂取 / 神経細胞 / 脂肪 / 嗜好 / 臨床疫学 / 社会医学 / 認知機能低下 / 脳血管障害 / 血栓溶解療法 / 急性期脳梗塞 / バイオバンク / 認知機能 / 急性期脳卒中 / 認知機能検査 / 認知機能障害 / ラクナ梗塞 / 脳卒中 / 脳小血管病 / disability / cotnitive impairment / cerebrovascular disease / 行動学 / 生理学 / 栄養学 / 褐色脂肪組織 / ストレス / 脳血流 / db/db マウス / 慢性低潅流 / db/dbマウス / インスリン抵抗性 / 脳虚血 / 高血圧 / 造血因子 / 慢性脳低灌流 / 側副血行 Less

Neuronal mechanism of hyperphagia in High fat foods
- Principal Investigator
  
  松村成暢
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Osaka Metropolitan University
Significance of tight junctions in glial cells and their involvement in neuropathologyPrincipal Investigator
- Principal Investigator
  
  Sasaki Tsutomu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Osaka University
Mechanism of suppression and induction of obesity by dietary fat
- Principal Investigator
  
  Matsumura Shigenobu
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Osaka Metropolitan University
  Osaka Prefecture University
  Kyoto University
Mechanism of obesity in female CRTC1 Knockout mice
- Principal Investigator
  
  Matsumura Shigenobu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Kyoto University
Research for cerebrovascular disease-related conditions
- Principal Investigator
  
  Kaori Miwa
- Project Period (FY)
  2017 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Epidemiology and preventive medicine
- Research Institution
  National Cardiovascular Center Research Institute
  Osaka University
Obesity induced by fat palatability and mental stress
- Principal Investigator
  
  Matsumura Shigenobu
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  Kyoto University
Novel therapy for neurological disorders by protein-protein interaction inhibitorPrincipal Investigator
- Principal Investigator
  
  SASAKI Tsutomu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied pharmacology
- Research Institution
  Osaka University
The role and mechanisms of TORC and HDAC signaling pathway and therapeutic new-class small compounds for neurological diseasePrincipal Investigator
- Principal Investigator
  
  sasaki tsutomu
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Osaka University
Mechanisms of arteriogenesis enhancement by granulocyte colony stimulating factor – Potential application to patients with subacute ischemic stroke
- Principal Investigator
  
  KITAGAWA KAZUO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Osaka University
Differential contribution of individual receptor subunits of N-methyl-d-aspartate to ischemic neuronal damage.Principal Investigator
- Principal Investigator
  
  SASAKI Tsutomu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Osaka University

[Book] 最新臨床脳卒中学（第2版）下最新の診断と治療ラクナ梗塞の急性期治療2022
- Author(s)
  藤堂　謙一、佐々木　勉、望月　秀樹
- Total Pages
  703
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-21K07414
[Book] 最新臨床脳卒中学（第2版）上最新の診断と治療　治療概論　慢性期の内科治療2022
- Author(s)
  佐々木　勉、権　泰史、藤堂　謙一
- Total Pages
  703
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-21K07414
[Journal Article] The tight junction protein occludin modulates blood brain barrier integrity and neurological function after ischemic stroke in mice2023
- Author(s)
  Sugiyama Shintaro、Sasaki Tsutomu、Tanaka Hiroo、Yan Haomin、Ikegami Takeshi、Kanki Hideaki、Nishiyama Kumiko、Beck Goichi、Gon Yasufumi、Okazaki Shuhei、Todo Kenichi、Tamura Atsushi、Tsukita Sachiko、Mochizuki Hideki
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 2892-2892
- DOI
  10.1038/s41598-023-29894-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07414, KAKENHI-PROJECT-20K16497, KAKENHI-PROJECT-20K06910, KAKENHI-PROJECT-19H03453, KAKENHI-PROJECT-21K15092, KAKENHI-PROJECT-19H05468
[Journal Article] <scp>CRTC1</scp> deficiency, specifically in melanocortin‐4 receptor‐expressing cells, induces hyperphagia, obesity, and insulin resistance2022
- Author(s)
  Matsumura Shigenobu、Miyakita Motoki、Miyamori Haruka、Kyo Satomi、Ishikawa Fuka、Sasaki Tsutomu、Jinno Tomoki、Tanaka Jin、Fujita Kotomi、Yokokawa Takumi、Goto Tsuyoshi、Momma Keiko、Takenaka Shigeo、Inoue Kazuo
- Journal Title
  
  The FASEB Journal
  
  Volume: 36 Issue: 12
- DOI
  10.1096/fj.202200617r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H02909, KAKENHI-PROJECT-20K19498, KAKENHI-PROJECT-19K24330
[Journal Article] MDMX elevation by a novel Mdmx?p53 interaction inhibitor mitigates neuronal damage after ischemic stroke2022
- Author(s)
  Yan Haomin、Sasaki Tsutomu、Kanki Hideaki、Hirata Yoshiyuki、Nishiyama Kumiko、Hisada Sunao、Matsumura Shigenobu、Nagaoka Yasuo、Sumiyoshi Takaaki、Nagano Seiichi、Nakata Akiko、Yoshida Minoru、Uesato Shinichi、Mochizuki Hideki
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 21110-21110
- DOI
  10.1038/s41598-022-25427-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07414, KAKENHI-PROJECT-21H02841, KAKENHI-PROJECT-19H05640
[Journal Article] Stimulation of G<sub>s</sub> signaling in MC4R cells by DREADD increases energy expenditure, suppresses food intake, and increases locomotor activity in mice2022
- Author(s)
  Matsumura Shigenobu、Miyakita Motoki、Miyamori Haruka、Kyo Satomi、Shima Daisuke、Yokokawa Takumi、Ishikawa Fuka、Sasaki Tsutomu、Jinno Tomoki、Tanaka Jin、Goto Tsuyoshi、Momma Keiko、Ishihara Kengo、Berdeaux Rebecca、Inoue Kazuo
- Journal Title
  
  American Journal of Physiology-Endocrinology and Metabolism
  
  Volume: 322 Issue: 5 Pages: E436-E445
- DOI
  10.1152/ajpendo.00439.2021
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K19498, KAKENHI-PROJECT-19K24330, KAKENHI-PROJECT-19H02909
[Journal Article] Disruption of CRTC1 and CRTC2 in Sim1 cells strongly increases high-fat diet intake in female mice but has a modest impact on male mice2022
- Author(s)
  Tanaka Jin、Ishikawa Fuka、Jinno Tomoki、Miyakita Motoki、Miyamori Haruka、Sasaki Tsutomu、Yokokawa Takumi、Goto Tsuyoshi、Inoue Kazuo、Matsumura Shigenobu
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 1 Pages: e0262577-e0262577
- DOI
  10.1371/journal.pone.0262577
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02909, KAKENHI-PROJECT-20K19498, KAKENHI-PROJECT-19K24330
[Journal Article] MiRNA-132/212 regulates tight junction stabilization in blood brain barrier after stroke2021
- Author(s)
  Yan Haomin、Kanki Hideaki、Matsumura Shigenobu、Kawano Tomohiro、Nishiyama Kumiko、Sugiyama Shintaro、Takemori Hiroshi、Mochizuki Hideki、Sasaki Tsutomu
- Journal Title
  
  Cell Death Discovery
  
  Volume: 7 Issue: 1 Pages: 380-380
- DOI
  10.1038/s41420-021-00773-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15695, KAKENHI-PROJECT-21K07414
[Journal Article] Loss of CREB Coactivator CRTC1 in SF1 Cells Leads to Hyperphagia and Obesity by High-fat Diet But Not Normal Chow Diet2021
- Author(s)
  Matsumura Shigenobu、Ishikawa Fuka、Sasaki Tsutomu、Terkelsen Mike Krogh、Ravnskjaer Kim、Jinno Tomoki、Tanaka Jin、Goto Tsuyoshi、Inoue Kazuo
- Journal Title
  
  Endocrinology
  
  Volume: 162 Issue: 9
- DOI
  10.1210/endocr/bqab076
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02909
[Journal Article] Cerebral microbleeds development after stroke thrombolysis: A secondary analysis of the THAWS randomized clinical trial2021
- Author(s)
  Kaori Miwa, Masatoshi Koga, Manabu Inoue, Sohei Yoshimura, Makoto Sasaki, Yusuke Yakushiji, Mayumi Fukuda-Doi, Yasushi Okada, Taizen Nakase, Masafumi Ihara, Yoshinari Nagakane, Shunya Takizawa, Koko Asakura, Junya Aoki, Kazumi Kimura, Haruko Yamamoto, Kazunori Toyoda
- Journal Title
  
  Int J Stroke
  
  Volume: - Issue: 6 Pages: 628-636
- DOI
  10.1177/17474930211035023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09084, KAKENHI-PROJECT-20K12707, KAKENHI-PROJECT-21K17241
[Journal Article] CREB coactivator CRTC2 plays a crucial role in endothelial function.2020
- Author(s)
  Kanki H, Sasaki T, Matsumura S, Kawano T, Todo K, Okazaki S, Nishiyama K, Takemori H, Mochizuki H.
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 40 (49) Issue: 49 Pages: 9533-9546
- DOI
  10.1523/jneurosci.0407-20.2020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08867, KAKENHI-PROJECT-18K19174
[Journal Article] Chronic high corticosterone with voluntary corn oil ingestion induces significant body weight gain in mice2019
- Author(s)
  Matsumura Shigenobu、Odanaka Mayuki、Ishikawa Fuka、Sasaki Tsutomu、Manio Mark Christian C.、Fushiki Tohru、Inoue Kazuo
- Journal Title
  
  Physiology & Behavior
  
  Volume: 204 Pages: 112-120
- DOI
  10.1016/j.physbeh.2019.01.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04924
[Journal Article] β-arrestin-2 in PAR-1-biased signaling has a crucial role in endothelial function via PDGF-β in stroke2019
- Author(s)
  Kanki Hideaki、Sasaki Tsutomu、Matsumura Shigenobu、Yokawa Satoru、Yukami Toshiro、Shimamura Munehisa、Sakaguchi Manabu、Furuno Tadahide、Suzuki Takahiro、Mochizuki Hideki
- Journal Title
  
  Cell Death & Disease
  
  Volume: 10 Issue: 2 Pages: 1375-1380
- DOI
  10.1038/s41419-019-1375-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04924
[Journal Article] A 9-Year Longitudinal Study of Basilar Artery Diameter2019
- Author(s)
  Takeuchi M, Miwa K, Tanaka M, Zhou Y, Todo K, Sasaki T, Sakaguchi M, Kitagawa K, Mochizuki H.
- Journal Title
  
  J Am Heart Assoc.
  
  Volume: 8 Issue: 5
- DOI
  10.1161/jaha.118.011154
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09084
[Journal Article] New 5-Aryl-Substituted 2-Aminobenzamide-Type HDAC Inhibitors with a Diketopiperazine Group and Their Ameliorating Effects on Ischemia-Induced Neuronal Cell Death.2018
- Author(s)
  Hirata Y, Sasaki T, Kanki H, Choong CJ, Nishiyama K, Kubo G, Hotei A, Taniguchi M, Mochizuki H, Uesato S.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 1400-1400
- DOI
  10.1038/s41598-018-19664-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05700, KAKENHI-PROJECT-17F17413, KAKENHI-PROJECT-16K15317
[Journal Article] Voluntary Corn Oil Ingestion Increases Energy Expenditure and Interscapular UCP1 Expression Through the Sympathetic Nerve in C57BL/6 Mice2018
- Author(s)
  Matsumura Shigenobu、Ishikawa Fuka、Sasaki Tsutomu、Odanaka Mayuki、Manio Mark Christian C.、Fushiki Tohru、Inoue Kazuo
- Journal Title
  
  Molecular Nutrition & Food Research
  
  Volume: 62 Issue: 22 Pages: 1800241-1800241
- DOI
  10.1002/mnfr.201800241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04924
[Journal Article] Plasma D-dimer levels and ischaemic lesions in multiple vascular regions can predict occult cancer in patients with cryptogenic stroke.2017
- Author(s)
  Gon Y, Sakaguchi M, Takasugi J, Kawano T, Kanki H, Watanabe A, Oyama N, Terasaki Y, Sasaki T, Mochizuki H.
- Journal Title
  
  Eur J Neurol.
  
  Volume: Mar;24(3) Issue: 3 Pages: 503-508
- DOI
  10.1111/ene.13234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15317
[Journal Article] Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner2017
- Author(s)
  Honorat Josephe A.、Nakatsuji Yuji、Shimizu Mikito、Kinoshita Makoto、Sumi-Akamaru Hisae、Sasaki Tsutomu、Takata Kazushiro、Koda Toru、Namba Akiko、Yamashita Kazuya、Sanda Eri、Sakaguchi Manabu、Kumanogoh Atsushi、Shirakura Takashi、Tamura Mizuho、Sakoda Saburo、Mochizuki Hideki、Okuno Tatsusada
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 11 Pages: e0187215-e0187215
- DOI
  10.1371/journal.pone.0187215
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09339, KAKENHI-PROJECT-16K15317
[Journal Article] Potential Application of 5-Aryl-Substituted 2-Amino- benzamide Type of HDAC1/2-Selective Inhibitors to Pharmaceuticals.2016
- Author(s)
  Uesato S, Hirata Y, Sasaki T.
- Journal Title
  
  Current Pharmaceutical Design
  
  Volume: 22, Dec Issue: 40 Pages: 6149-6159
- DOI
  10.2174/1381612822666161208143417
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K15317
[Journal Article] Characteristics of cryptogenic stroke in cancer patients2016
- Author(s)
  Gon Y, Okazaki S, Terasaki Y, Sasaki T, Yoshimine T, Sakaguchi M, Mochizuki H.
- Journal Title
  
  Ann Clin Transl Neurol.
  
  Volume: Feb 11;3(4) Issue: 4 Pages: 280-7
- DOI
  10.1002/acn3.291
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390222
[Journal Article] Discovery of new low-molecular-weight p53-Mdmx disruptors and their anti-cancer activities2016
- Author(s)
  Uesato, S.; Matsuura, Y.; Matsue, S.; Sumiyoshi, T.; Hirata, Y.; Takemoto, S.; Kawaratani, Y.; Yamai, Y.; Ishida, K.; Sasaki, T.; Enari, M.
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 24 Issue: 8 Pages: 1919-1926
- DOI
  10.1016/j.bmc.2016.03.021
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18903, KAKENHI-PROJECT-24390222, KAKENHI-PROJECT-16K15317
[Journal Article] A novel histone deacetylase 1 and 2 isoform-specific inhibitor alleviates experimental Parkinson's disease.2016
- Author(s)
  Choong CJ, Sasaki T, Hayakawa H, Yasuda T, Baba K, Hirata Y, Uesato S, Mochizuki H.
- Journal Title
  
  Neurobiology of Aging
  
  Volume: 37 Pages: 103-116
- DOI
  10.1016/j.neurobiolaging.2015.10.001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01558, KAKENHI-PROJECT-24390222
[Journal Article] Association between cerebral small vessel diseases and mild parkinsonian signs in the elderly with vascular risk factors.2016
- Author(s)
  Hatate J, Miwa K, Matsumoto M, Sasaki T, Yagita Y, Sakaguchi M, Kitagawa K, Mochizuki H.
- Journal Title
  
  Parkinsonism Relat Disord.
  
  Volume: Feb 13. pii: S1353-8020(16) Pages: 30039-6
- DOI
  10.1016/j.parkreldis.2016.02.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390222, KAKENHI-PROJECT-15K19227
[Journal Article] Serine racemase inhibition induces nitric oxide-mediated neurovascular protection during cerebral ischemia2016
- Author(s)
  Watanabe A, Sasaki T, Kanki H, Yukami T, Takemori H, Sakaguchi M, Kitagawa K, Mochizuki H
- Journal Title
  
  Neuroscience
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390222
[Journal Article] Chronic Elevation of Tumor Necrosis Factor-α Mediates the Impairment of Leptomeningeal Arteriogenesis in db/db Mice.2015
- Author(s)
  Yukami T, Yagita Y, Sugiyama Y, Oyama N, Watanabe A, Sasaki T, Sakaguchi M, Mochizuki H, Kitagawa K.
- Journal Title
  
  Stroke
  
  Volume: 46 Issue: 6 Pages: 1657-63
- DOI
  10.1161/strokeaha.114.008062
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04844, KAKENHI-PROJECT-24390222
[Journal Article] Granulocyte colony-stimulating factor fails to enhance leptomeningeal collateral growth in spontaneously hypertensive rats2014
- Author(s)
  Sugiyama Y, Yagita Y, Yukami T, Watanabe A, Oyama N, Terasaki Y, Omura-Matsuoka E, Sasaki T, Mochizuki H, Kitagawa K
- Journal Title
  
  Neurosci Lett
  
  Volume: 564 Pages: 16-20
- DOI
  10.1016/j.neulet.2014.01.053
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390234, KAKENHI-PROJECT-24591260, KAKENHI-PROJECT-24390222
[Journal Article] Altered Actions of Memantine and NMDA-Induced Currents in a New Grid2-Deleted Mouse Line.2014
- Author(s)
  Ayako Kumagai, Akira Fujita, Tomoki Yokoyama, Yuki Nonobe, Yasuhiro Hasaba, Tsutomu Sasaki, Yumi Itoh, Minako Koura, Osamu Suzuki, Shigeki Adachi, Haruko Ryo, Arihiro Kohara, Lokesh P. Tripathi, Masato Sanosaka, Toshiki Fukushima, Taisei Nomura, Hiroshi Takemori, et al.
- Journal Title
  
  Genes
  
  Volume: 5 Issue: 4 Pages: 1095-1114
- DOI
  10.3390/genes5041095
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23241023, KAKENHI-PROJECT-25430186, KAKENHI-PROJECT-25670155, KAKENHI-PROJECT-25740023, KAKENHI-PROJECT-26430012, KAKENHI-PROJECT-26670196, KAKENHI-PROJECT-24390222
[Journal Article] Functional deterioration of endothelial nitric oxide synthase after focal cerebral ischemia2013
- Author(s)
  Yagita Y, Kitagawa K, Oyama N, Yukami T, Watanabe A, Sasaki T, Mochizuki H
- Journal Title
  
  J Cereb Blood Flow Metab
  
  Volume: 33 Issue: 10 Pages: 1532-9
- DOI
  10.1038/jcbfm.2013.112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390234, KAKENHI-PROJECT-24390222, KAKENHI-PROJECT-24591260
[Journal Article] CREB activation is a key player for ischemic tolerance in the brain2012
- Author(s)
  Kitagawa K, Sasaki T, Terasaki Y, Yagita Y, Mochizuki H
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 52(11) Pages: 904-7
- NAID
  130004505204
- Data Source
  KAKENHI-PROJECT-23390234
[Journal Article] Suppression of dynamin GTPase decreases alpha-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy.2012
- Author(s)
  Konno M, Hasegawa T, Baba T, Miura E, Sugeno N, Kikuchi A, Fiesel FC, Sasaki T, Aoki M, Itoyama Y, Takeda A.
- Journal Title
  
  Mol Neurodegener
  
  Volume: 7 Issue: 1 Pages: 38-38
- DOI
  10.1186/1750-1326-7-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591228, KAKENHI-PROJECT-23591266, KAKENHI-PROJECT-23790974, KAKENHI-PROJECT-24390219, KAKENHI-PROJECT-24390222, KAKENHI-PROJECT-24659423, KAKENHI-PUBLICLY-24111502
[Journal Article] CREB activation is a key player for ischemic tolerance in the brain .2012
- Author(s)
  Kitagawa K, Sasaki T, et. al.
- Journal Title
  
  Rinsho Shinkeigaku.
  
  Volume: 52(11) Pages: 904-2
- NAID
  130004505204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390222
[Journal Article] A potent inhibitor of SIK2, 3,3',7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells2011
- Author(s)
  A.Kumagai, N.Horike, Y.Satoh, H.Takemori, Y.Naeaoka, 他6名
- Journal Title
  
  PLoS ONE
  
  Volume: 6 Issue: 10 Pages: 26148-26148
- DOI
  10.1371/journal.pone.0026148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590131, KAKENHI-PROJECT-21591081
[Journal Article] Granulocyte colony-stimulating factor enhances arteriogenesis and amelioratescerebral damage in a mouse model of ischemic stroke.2011
- Author(s)
  Sugiyama Y, Yagita Y, Sasaki T, et.al.
- Journal Title
  
  Stroke
  
  Volume: 42(3) Pages: 770-775
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591081
[Journal Article] SIK2 is a key regulator for neuronal survival after ischemia via TORC1-CREB2011
- Author(s)
  Sasaki T, et.al.
- Journal Title
  
  Neuron
  
  Volume: 69(1) Issue: 1 Pages: 106-119
- DOI
  10.1016/j.neuron.2010.12.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591081, KAKENHI-PROJECT-22591015
[Journal Article] Granulocyte colony-stimulating factor enhances arteriogenesis and ameliorates cerebral damage in a mouse model of ischemic stroke2011
- Author(s)
  Sugiyama Y, Yagita Y, Oyama N, Terasaki Y, Omura-Matsua E, Sasaki T, Kitagawa K.
- Journal Title
  
  Stroke
  
  Volume: 42(3) Issue: 3 Pages: 770-5
- DOI
  10.1161/strokeaha.110.597799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591081, KAKENHI-PROJECT-23390234
[Journal Article] SIK2 is a new key regulator for neuronal survival after ischemia through TORC1-CREB2011
- Author(s)
  Sasaki T, Takemori H, Yagita Y, Terasaki Y, Uebi T, Horike N, Takagi H, Susumu T, Teraoka H, Kusano K, Hatano O, Oyama N, Sugiyama Y, Sakoda S, Kitagawa K.
- Journal Title
  
  Neuron
  
  Volume: 13 ; 69(1) Pages: 106-19
- URL
  http://dx.doi.org/10.1016/j.neuron.2010.12.004,
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591081
[Journal Article] SIK2 is a key regulator for neuronal survival after ischemia via TORC1-CREB.2011
- Author(s)
  Sasaki T, et.al.
- Journal Title
  
  Neuron
  
  Volume: 69(1) Pages: 106-119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591081
[Journal Article] Cilostazol, not aspirin, reduces ischemic brain injury via endothelial protection in spontaneously hypertensive rats2011
- Author(s)
  Oyama N, Yagita Y, et al
- Journal Title
  
  Stroke
  
  Volume: 89 Issue: 9 Pages: 2571-2577
- DOI
  10.1161/strokeaha.110.609834
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591080, KAKENHI-PROJECT-21591081, KAKENHI-PROJECT-23390234
[Journal Article] An angiotensin II type 1 receptor blocker can preserve endothelial function and attenuate brain ischemic damage in spontaneously hypertensive rats.2010
- Author(s)
  Oyama N, Yagita Y, Sasaki T, et al.
- Journal Title
  
  J Neurosci Res
  
  Volume: 88(13) Pages: 2889-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591081
[Journal Article] Activation of NR2A receptors induces ischemic tolerance through CREB signaling2010
- Author(s)
  Terasaki Y, Sasaki T, et al.
- Journal Title
  
  J Cereb Blood Flow & Metab (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591081
[Journal Article] Downregulation of SIK2 expression promotes the melanogenic program in mice2010
- Author(s)
  Horike N, Kumagai A, Shimono Y, Onishi T, Itoh Y, Sasaki T, Kitagawa K, Hatano O, Takagi H, Susumu T, Teraoka H, Kusano K, Nagaoka Y, Kawahara H, Takemori H.
- Journal Title
  
  Pigment Cell Melanoma Res
  
  Volume: 23(6) Issue: 6 Pages: 809-19
- DOI
  10.1111/j.1755-148x.2010.00760.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591081
[Journal Article] Activation of NR2A receptors induces ischemic tolerance through CREB signaling2010
- Author(s)
  Terasaki Y, Sasaki T, Yagita Y, Okazaki S, Sugiyama Y, Oyama N, Omura-ME, Sakoda S, Kitagawa K.
- Journal Title
  
  J Cereb Blood Flow Metab
  
  Volume: 30 Issue: 8 Pages: 1441-1449
- DOI
  10.1038/jcbfm.2010.18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591081
[Patent] 含窒素複素環誘導体、神経保護剤及びがん治療用医薬組成物2015
- Inventor(s)
  佐々木勉、望月秀樹、Choong CJ、上里新一、住吉孝之
- Industrial Property Rights Holder
  佐々木勉、望月秀樹、Choong CJ、上里新一、住吉孝之
- Industrial Property Rights Type
  特許
- Filing Date
  2015-09-09
- Overseas
- Data Source
  KAKENHI-PROJECT-24390222
[Patent] アシルアミノフェニル基を有する化合物及びその用途2015
- Inventor(s)
  佐々木勉、望月秀樹、Choong CJ、上里新一、住吉孝之
- Industrial Property Rights Holder
  佐々木勉、望月秀樹、Choong CJ、上里新一、住吉孝之
- Industrial Property Rights Type
  特許
- Filing Date
  2015-11-25
- Overseas
- Data Source
  KAKENHI-PROJECT-24390222
[Patent] アイソフォーム特異的新規 HDAC 阻害剤による神経疾患治療法の開発2014
- Inventor(s)
  佐々木勉、望月秀樹、Choong CJ、上里新一、平田佳之
- Industrial Property Rights Holder
  佐々木勉、望月秀樹、Choong CJ、上里新一、平田佳之
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-183239
- Filing Date
  2014-09-09
- Data Source
  KAKENHI-PROJECT-24390222
[Patent] アシルアミノフェニル基を有する化合物及びその用途2014
- Inventor(s)
  佐々木勉、望月秀樹、Choong CJ、上里新一
- Industrial Property Rights Holder
  佐々木勉、望月秀樹、Choong CJ、上里新一
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-237826
- Filing Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-24390222
[Patent] 新規含窒素複素環誘導体2014
- Inventor(s)
  上里新一、住吉孝明、平田佳之、望月秀樹、佐々木勉
- Industrial Property Rights Holder
  上里新一、住吉孝明、平田佳之、望月秀樹、佐々木勉
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-183235
- Filing Date
  2014-09-09
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] Effect of salt-inducible kinase on Ca2+ oscillations in primar y neuronal cultures2024
- Author(s)
  Sasaki T, Kanki H, Kawano T, Yan H, Ikegami T, NIshiyama K, Okazaki S, Todo K, Matsumura S, Nagano S, MOchizuki H
- Organizer
  第65回日本神経学会総会
- Data Source
  KAKENHI-PROJECT-21K07414
[Presentation] スフェロイド神経培養におけるCa2+振動に対する塩誘導性キナーゼSIKの影響2023
- Author(s)
  佐々木勉、神吉秀明、河野友裕、西山久美子、久田素、松村成暢、望月秀樹
- Organizer
  第29回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07414
[Presentation] Mdmx plays a crucial role in neuronal damage after ischemic stroke.2022
- Author(s)
  Yan Haomin, Sasaki Tsutomu, Kanki hideaki, Nishiyama Kumiko, Nagano Seiichi, Mochizuki Hideki
- Organizer
  第28回遺伝子細胞治療学会学術集会(JSGCT2022)
- Data Source
  KAKENHI-PROJECT-21K07414
[Presentation] The effect of occludin deficiency in Tight Junction in Blood Brain Barrier after stroke.2022
- Author(s)
  Shintaro Sugiyama, Tsutomu Sasaki, Hiroo Tanaka, Yan Haomin, Takeshi Ikegami, Hideaki Kanki, Atsushi Tamura, Sachiko Tsukita, Hideki Mochizuki.
- Organizer
  第63回日本神経学会総会
- Data Source
  KAKENHI-PROJECT-21K07414
[Presentation] 急性期脳梗塞のHot topics. (シンポジウム)病理、基礎2022
- Author(s)
  佐々木　勉
- Organizer
  第41回日本画像医学会.
- Invited
- Data Source
  KAKENHI-PROJECT-21K07414
[Presentation] がん診断時の好中球/リンパ球比はがん診断から2年以内の脳梗塞発症を予測する2021
- Author(s)
  佐々木勉、権泰史、河野友裕、岡崎周平、松村泰志、Huang Ao, 服部聡、藤堂謙一、望月　秀樹
- Organizer
  Stroke 2022
- Invited
- Data Source
  KAKENHI-PROJECT-21K07414
[Presentation] The role of occludin in Tight Junction in Blood Brain Barrier after stroke2021
- Author(s)
  Shintaro Sugiyama, Tsutomu Sasaki, Hiroo Tanaka, Yen Haomin, Hideaki Kanki, Atsushi Tamura, Sachiko Tsukita, Hideki Mochizuki
- Organizer
  第62回日本神経学会総会.
- Data Source
  KAKENHI-PROJECT-21K07414
[Presentation] 急性期脳梗塞のHot topics　基礎と病理2021
- Author(s)
  佐々木　勉
- Organizer
  第41回日本画像医学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07414
[Presentation] Examination of regulation of expression of nAChR by TMEM35 after cerebral ischemia2021
- Author(s)
  佐々木勉、Yan Haomin、神吉秀明、河野友裕、杉山慎太郎、松村成暢、望月秀樹
- Organizer
  第62回日本神経学会総会.
- Data Source
  KAKENHI-PROJECT-21K07414
[Presentation] 脳虚血時における分泌型Lynx1の動態の検討2018
- Author(s)
  佐々木勉、神吉　秀明、松村　成暢、河野　友裕、上里　新一、坂口　学、望月秀樹
- Organizer
  第43回日本脳卒中学会学術集会（STROKE 2018）
- Data Source
  KAKENHI-PROJECT-16K15317
[Presentation] CRTC2 played important role for ischemic stroke2018
- Author(s)
  Hideaki Kanki, Tsutomu Sasaki, Manabu Sakaguchi, Hideki Mochizuki
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-16K15317
[Presentation] Screening for small-molecule inhibitors of protein-protein interaction (PPI) with neuroprotective effect in experimental PD2017
- Author(s)
  Choong CJ, Sasaki T, Baba K, Hirata Y, Uesato S and Mochizuki H
- Organizer
  The XXIII World Congress of Neurology (WCN 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15317
[Presentation] CRTC2 enhanced angiogenesis and endothelial function2017
- Author(s)
  Hideaki Kanki, Tsutomu Sasaki, Manabu Sakaguchi, Hideki Mochizuki
- Organizer
  The XXIII World Congress of Neurology (WCN 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15317
[Presentation] The mechanisms of neuroprotective effects of isoform selective HDAC inhibitors for brain ischemia.2017
- Author(s)
  Sasaki T, Kanki H, Choong CJ, Baba K, Hirata Y, Sakaguchi M, Uesato S and Mochizuki H
- Organizer
  The XXIII World Congress of Neurology (WCN 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15317
[Presentation] Small-molecule p53/negative regulator-interaction inhibitors confer neuroprotection against MPP+/MPTP-induced neurotoxicity in experimental PD2017
- Author(s)
  Chi-Jing Choong, Tsutomu Sasaki, Hideki Hayakawa, Kousuke Baba, Yoshiyuki Hirata, Shinichi Uesato, and Hideki Mochizuki
- Organizer
  Suzhou Basic Scientists Summer School 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15317
[Presentation] Selective inhibition of NR2B attenuates ischemic neuronal injury in neuronal culture and rats2016
- Author(s)
  Terasaki Y, Sasaki T, Yukami T, Oyama N, Yagita Y, Sakaguchi M, Kitagawa K, Mochizuki H
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] Novel HDAC1/2 isoform-specific inhibitor K560 ameliorates MPP+/MPTP-mediated experimental Parkinson’s disease2016
- Author(s)
  Chi-Jing Choong, Tsutomu Sasaki, Hideki Hayakawa, Toru Yasuda, Kousuke Baba, Yoshiyuki Hirata, Shinichi Uesato, and Hideki Mochizuki
- Organizer
  AOPMC 2016 (5th Asian and Oceanian Parkinson’s Disease and Movement Disorders Congress)
- Place of Presentation
  MANILA, PHILIPPINES
- Year and Date
  2016-03-11
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] Serine racemase inhibition induces NO-mediated neurovascular protection during cerebral ischemia2016
- Author(s)
  Watanabe A, Sasaki T, Kanki H, Yukami T, Takemori H, Sakaguchi M, Mochizuki H
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] Effect of thrombin and cAMP-PKA signaling on the angiogenesis in brain microvasculature2016
- Author(s)
  Kanki H, Sasaki T, Watanabe A, Yukami T, Sakaguchi M, Mochizuki H
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] Efficacy and implications of isoform selective Histone deacetylase inhibitors for cerebral ischemia2016
- Author(s)
  Sasaki T, Chonng Chi-Jing, Watanabe A, Kanki H, Yukami T, Hayakawa H, Yasuda T, Baba K, Sakaguchi M, Uesato S, Mochizuki H
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] 脳虚血におけるSRR-Serineの役割について2015
- Author(s)
  渡邊　彰弘、佐々木　勉、神吉　秀明、由上登志郎、竹森　洋、坂口　学、望月秀樹
- Organizer
  第27回日本脳循環代謝学会総会
- Place of Presentation
  富山
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] A novel histone deacetylase 1 and 2 isoform-specific inhibitor alleviates experimental Parkinson's disease.2015
- Author(s)
  Chi-Jing Choong, Tsutomu Sasaki, Hideki Hayakawa, Toru Yasuda, Kousuke Baba, Yoshiyuki Hirata, Shinichi Uesato, and Hideki Mochizuki
- Organizer
  XXI World Congress on Parkinson’s Disease and Related Disorders. IAPRD 2015
- Place of Presentation
  Milan, Italy
- Year and Date
  2015-12-06
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] Efficacy and implications of selective class I or II Histone deacetylase inhibitors for neurological disorders.2015
- Author(s)
  CJ Choong, T Sasaki, H Hayakawa, K Baba, Watanabe A, Y Hirata, S Uesato and H Mochizuki
- Organizer
  17th Annual Meeting of the American Society for Experimental NeuroTherapeutics (ASENT 2015)
- Place of Presentation
  Georgetown University Hotel And Conference Center, District of Columbia, Washington, USA
- Year and Date
  2015-02-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] 脳虚血におけるPGC-1αシグナルの調節機構の検討2015
- Author(s)
  佐々木勉、渡邊　彰弘、神吉　秀明、由上登志郎、竹森　洋、坂口　学、望月秀樹
- Organizer
  第27回日本脳循環代謝学会総会
- Place of Presentation
  富山
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] アイソフォーム特異的HDAC阻害剤による虚血性脳血管障害の治療検討2015
- Author(s)
  佐々木　勉、鐘　其静、渡邊　彰弘、神吉　秀明、馬場　孝輔、平田　佳之、坂口　学、上里　新一、望月　秀樹
- Organizer
  第33回日本神経治療学会総会 The 33rd Annual Meeting of Japanese Society of Neurological Therapeutics
- Place of Presentation
  名古屋
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] 脳虚血におけるCRTC-PGC-1αシグナルの動態についての検討2014
- Author(s)
  佐々木　勉、渡邊彰弘、神吉秀明、由上登志郎、竹森　洋、坂口　学、望月秀樹
- Organizer
  第51回日本臨床分子医学会総会
- Place of Presentation
  東京国際フォーラム、東京都千代田区
- Year and Date
  2014-04-11
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] ニコチン性アセチルコリン受容体活性化による神経保護作用の検討2014
- Author(s)
  佐々木勉、北川一夫、渡邉彰弘、竹森　洋、渡邊　彰弘、由上登志郎、竹森　洋、望月秀樹
- Organizer
  日本脳卒中学会(Stroke2014)
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] 脳虚血時のCRTC-PGC-1αシグナルの動態2014
- Author(s)
  佐々木　勉、北川一夫、八木田佳樹、由上登志郎、佐野坂真人、八木田佳樹、竹森　洋、望月秀樹
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場、福岡県福岡市博多区
- Year and Date
  2014-05-21
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] 脳虚血におけるCRTC-PGC-1αシグナルの動態についての検討2014
- Author(s)
  佐々木勉、竹森　洋、渡邊　彰弘、由上登志郎、北川一夫、望月秀樹
- Organizer
  臨床分子医学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] 2型糖尿病では脳軟膜動脈吻合の発達は障害される2014
- Author(s)
  由上登志郎、八木田佳樹、渡邊彰弘、佐々木勉、坂口学、望月秀樹、北川一夫
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場、福岡県福岡市博多区
- Year and Date
  2014-05-21
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] Efficacy and implications of selective class I or II Histone deacetylase inhibitors for ischemic brain injury.2014
- Author(s)
  Sasaki T, Choong CJ, Watanabe A, Hirata Y, Sanosaka M, Yukami T, Kitagawa K, Takemori H, Uesato S, Mochizuki H.
- Organizer
  American Neurological Association's 2014 Annual Meeting
- Place of Presentation
  Baltimore Marriott Waterfront Hotel, Maryland, USA
- Year and Date
  2014-10-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] 脳勝血管内皮細胞間接着結合に対する脳虚血の影響2013
- Author(s)
  八木田佳樹, 北川一夫, 大山直記, 由上登志郎, 佐々木勉, 望月秀樹
- Organizer
  第38回日本脳卒中学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390234
[Presentation] 脳側副血管発達に対する糖尿病の影響2013
- Author(s)
  由上登志郎, 八木田佳樹, 佐々木勉, 望月秀樹, 北川一夫
- Organizer
  第25回日本脳循環代謝学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23390234
[Presentation] A Role of CREB-CRTC signaling in nicotine-induced neuroprotection.2013
- Author(s)
  T Sasaki, K Kitagawa, A Watanabe, T Yukami, N Oyama, Y Yagita, H Takemori, and H Mochizuki
- Organizer
  Brain 2013
- Place of Presentation
  Shanghai, China
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] ニコチンによる神経保護機構の検討2013
- Author(s)
  佐々木勉、北川一夫、渡邊彰弘、由上登志郎、八木田佳樹、竹森　洋、望月秀樹
- Organizer
  第54回日本神経学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] 中枢神経系におけるCRTC-CREB制御機構とその役割2012
- Author(s)
  佐々木勉
- Organizer
  第24回日本脳循環代謝学会総会
- Place of Presentation
  広島(招待講演)
- Year and Date
  2012-11-08
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] ニコチンによるCREB活性化を介した神経保護機構の検討2012
- Author(s)
  佐々木勉
- Organizer
  第24回日本脳循環代謝学会総会
- Place of Presentation
  広島
- Year and Date
  2012-11-09
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] 2型糖尿病モデルマウスにおける脳側副血管の発達についての検討2012
- Author(s)
  由上登志郎、八木田佳樹、大山直紀、佐々木勉、望月秀樹、北川一夫
- Organizer
  第24回日本脳循環代謝学会総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23390234
[Presentation] 脳虚血耐性時における塩誘導キナーゼ(SIK)-CRTC経路の意義2012
- Author(s)
  佐々木勉
- Organizer
  第53回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2012-05-25
- Data Source
  KAKENHI-PROJECT-21591081
[Presentation] 高血圧自然発症ラットにおける脳軟膜動脈吻合の発達障害2012
- Author(s)
  杉山幸生, 八木田佳樹, 大山直樹, 由上登志郎, 佐々木勉, 望月秀樹, 北川一夫
- Organizer
  第37回日本脳卒中学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390234
[Presentation] A Role of CREB-CRTC signaling in nicotine-mediated neuroprotection2012
- Author(s)
  Sasaki Tsutomu
- Organizer
  Neuroscience2012(第35回日本神経科学会総会)
- Place of Presentation
  Nagoya
- Year and Date
  2012-09-18
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] 脳虚血時における内因性保護シグナルの検討2012
- Author(s)
  北川一夫、佐々木勉
- Organizer
  第53回日本神経学会総会(招待講演)
- Place of Presentation
  東京
- Year and Date
  2012-05-23
- Data Source
  KAKENHI-PROJECT-21591081
[Presentation] 脳虚血耐性時における塩誘導性キナーゼ(SIK)-CRTC経路の動態。2012
- Author(s)
  佐々木勉
- Organizer
  第53回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2012-05-25
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] 脳虚血後SIK2-TORC1-CREB経路の動態2011
- Author(s)
  佐々木勉
- Organizer
  第36回日本脳卒中学会総会(Stroke2011)
- Place of Presentation
  京都
- Year and Date
  2011-08-01
- Data Source
  KAKENHI-PROJECT-21591081
[Presentation] Implication of TORC1-CREB cascade in neuronal survival2011
- Author(s)
  Sasaki T et al.
- Organizer
  Brain 2011
- Place of Presentation
  Barcelona(Spain)
- Year and Date
  2011-05-27
- Data Source
  KAKENHI-PROJECT-21591081
[Presentation] Selective inhibition of NR2B-containing NMDAR attenuates neuronal Injury ofter OGD and in cortical neuron and permanent MCAO2011
- Author(s)
  寺崎泰和、佐々木勉
- Organizer
  American Stroke Association
- Place of Presentation
  Los Angeles(USA)
- Year and Date
  2011-02-11
- Data Source
  KAKENHI-PROJECT-21591081
[Presentation] 塩誘導性キナーぜ(SIK2)によるTORC1-CREB経路を介する神経保護効果2011
- Author(s)
  佐々木勉
- Organizer
  第52回日本神経学会総会
- Place of Presentation
  名古屋
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-21591081
[Presentation] 脳虚血時におけるSIK-TORC1経路の意義2011
- Author(s)
  佐々木勉
- Organizer
  9th Future Forum Japan Symposium(招待講演)
- Place of Presentation
  神戸
- Year and Date
  2011-07-08
- Data Source
  KAKENHI-PROJECT-21591081
[Presentation] 脳虚血後CaMKによるCRTC1-CREB制御機構に関する検討2011
- Author(s)
  佐々木勉
- Organizer
  第23回日本脳循環代謝学会総会
- Place of Presentation
  東京
- Year and Date
  2011-11-05
- Data Source
  KAKENHI-PROJECT-21591081
[Presentation] 神経細胞におけるニコチンによるCREB調節機構の検討2011
- Author(s)
  佐々木勉
- Organizer
  第23回日本脳循環代謝学会総会
- Place of Presentation
  東京
- Year and Date
  2011-11-05
- Data Source
  KAKENHI-PROJECT-21591081
[Presentation] 脳虚血時におけるSIK-TORC1経路の意義2011
- Author(s)
  佐々木勉
- Organizer
  9th Future Forum Japan Symposium
- Place of Presentation
  神戸(招待講演)
- Year and Date
  2011-07-08
- Data Source
  KAKENHI-PROJECT-21591081
[Presentation] A role for SIK2-TORC1 cascade in neuronal survival after ischemia2010
- Author(s)
  佐々木勉
- Organizer
  Neuro 2010
- Place of Presentation
  神戸
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-21591081
[Presentation] 脳虚血後CREB-CRE制御機構におけるbZIPドメインの重要性2010
- Author(s)
  佐々木勉
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-23
- Data Source
  KAKENHI-PROJECT-21591081
[Presentation] 脳虚血後CREB-CRE制御におけるbZIPドメインの重要性2010
- Author(s)
  佐々木勉
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-21591081
[Presentation] A role for SIK2-TORC1 cascade in neuronal survival after ischemia2010
- Author(s)
  佐々木勉
- Organizer
  Neuro2010
- Place of Presentation
  神戸
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-21591081
[]

1. Matsumura Shigenobu (70467413)

# of Collaborated Projects: 5 results

# of Collaborated Products: 11 results
2. KITAGAWA Kazuo (70301257)

# of Collaborated Projects: 3 results

# of Collaborated Products: 24 results
3. nagaoka yasuo (90243039)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. YAGITA Yoshiki (20403066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. takemori hiroshi (90273672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
6. mochiduki hideki (90230044)

# of Collaborated Projects: 1 results

# of Collaborated Products: 23 results
7. uesato shinnichi (50111969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
8. Kaori Miwa (80645341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 坂口学 (70432474)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 藤堂謙一 (40403068)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 大山直紀 (90622895)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 高杉純司 (40796033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 権泰史 (70751311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 平田佳之 (00745854)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
15. 田村淳 (00362525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. 原田直樹 (00529141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 西園啓文 (10502289)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. OKUNO Tatsusada

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. NAKATSUJI Yuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 神吉秀明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 長谷川隆文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 武田篤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 住吉孝明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 梁治子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 野村大成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 横川拓海

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 甲田亨

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 南波明子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 山下和哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SASAKI TSUTOMU 佐々木 勉

SASAKI Tsutomu 佐々木 勉

Research Projects

Research Products

Co-Researchers

Neuronal mechanism of hyperphagia in High fat foods

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Significance of tight junctions in glial cells and their involvement in neuropathologyPrincipal Investigator

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Mechanism of suppression and induction of obesity by dietary fat

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Mechanism of obesity in female CRTC1 Knockout mice

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Research for cerebrovascular disease-related conditions

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Obesity induced by fat palatability and mental stress

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Novel therapy for neurological disorders by protein-protein interaction inhibitorPrincipal Investigator

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The role and mechanisms of TORC and HDAC signaling pathway and therapeutic new-class small compounds for neurological diseasePrincipal Investigator

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Mechanisms of arteriogenesis enhancement by granulocyte colony stimulating factor – Potential application to patients with subacute ischemic stroke

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Differential contribution of individual receptor subunits of N-methyl-d-aspartate to ischemic neuronal damage.Principal Investigator

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[Book] 最新臨床脳卒中学（第2版）下 最新の診断と治療 ラクナ梗塞の急性期治療2022

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[Book] 最新臨床脳卒中学（第2版）上 最新の診断と治療 治療概論 慢性期の内科治療2022

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[Journal Article] The tight junction protein occludin modulates blood brain barrier integrity and neurological function after ischemic stroke in mice2023

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SASAKI TSUTOMU 佐々木勉

SASAKI Tsutomu 佐々木勉

[Book] 最新臨床脳卒中学（第2版）下最新の診断と治療ラクナ梗塞の急性期治療2022

[Book] 最新臨床脳卒中学（第2版）上最新の診断と治療　治療概論　慢性期の内科治療2022