KOBAYASHI Toshihiro 小林俊寛

… Alternative Names

Kobayashi Toshihiro 小林俊寛

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Researcher Number	20587414
Other IDs
Affiliation (Current)	2025: 東京大学, 医科学研究所, 特任准教授 2025: 生理学研究所, 生体機能調節研究領域, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 東京大学, 医科学研究所, 特任准教授 2017 – 2020: 生理学研究所, 行動・代謝分子解析センター, 助教 2011 – 2012: 東京大学, 医科学研究所, 客員研究員
Review Section/Research Field	Principal Investigator Basic Section 42030:Animal life science-related / Basic Section 42040:Laboratory animal science-related / Biological Sciences / Laboratory animal science / Laboratory animal science Except Principal Investigator Biological Sciences / Biological Sciences / Basic Section 42040:Laboratory animal science-related
Keywords	Principal Investigator 多能性幹細胞 / 始原生殖細胞 / ラット / ウサギ / 原腸陥入 / 三胚葉 / 臓器再生 / エピブラスト幹細胞 / ブタ / 再生医学 … More / 発生・分化 / キメラ / 4倍体胞補完法 / 異種間キメラ / マウス / 4倍体補完法 … More Except Principal Investigator 生殖細胞 / 配偶子 / 卵巣 / 精巣 / 生殖補助技術 / 受精 / 生殖細胞系列 / 幹細胞 / 体外培養 / 配偶子形成 / H2BVenus / ノックアウトラット / ノックインラット / CRISPR/Cas9法 / 胚盤胞補完 / Prdm14 / ES/iPS細胞 / エピブラスト / 多能性幹細胞 / 胚盤胞補完法 / 異種キメラ / 生殖細胞欠損 / Prdm14遺伝子 / 卵子 / 精子 / 始原生殖細胞 Less

Establishment of tetraploid complementation competent pluripotent stem cells in ratsPrincipal Investigator
- Principal Investigator
  
  小林俊寛
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  The University of Tokyo
Next-generation ART: Building a global network to create innovative technologies in m ammalian reproductive engineering
- Principal Investigator
  
  林克彦
- Project Period (FY)
  2023 – 2029
- Research Category
  
  Fund for the Promotion of Joint International Research (International Leading Research )
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Genetic analysis of primordial germ cell using pig epiblast stem cells and cloned embryosPrincipal Investigator
- Principal Investigator
  
  Kobayashi Toshihiro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  The University of Tokyo
  National Institute for Physiological Sciences
Developmental analysis of xenogenic germ cells using blastocyst complementation
- Principal Investigator
  
  HIRABAYASHI Masumi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  National Institute for Physiological Sciences
Adaptation of in vitro gametogenesis across a wide range of speciesPrincipal Investigator
- Principal Investigator
  
  Kobayashi Toshihiro
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
  National Institute for Physiological Sciences
目的臓器作出に向けた一胚葉特異的なキメラ作製法の開発Principal Investigator
- Principal Investigator
  
  小林俊寛
- Project Period (FY)
  2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  National Institute for Physiological Sciences
Ensuring integrity of gametogenesis
- Principal Investigator
  
  HAYASHI Katsuhiko
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
ウサギES細胞からの始原生殖細胞誘導法とそれを用いた生殖系列キメラ作製法の開発Principal Investigator
- Principal Investigator
  
  小林俊寛
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Laboratory animal science
- Research Institution
  National Institute for Physiological Sciences
Generate pluripotent stem cell derived animals by using interspecific blastocyst complementationPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Toshihiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo

All 2024 2022 2021 2020 2019 2018 2017 2013 2012 2011

All Journal Article Presentation Book

[Book] 肝胆膵2012
- Author(s)
  小林俊寛, 中内啓光
- Publisher
  アークメディア
- Data Source
  KAKENHI-PROJECT-23700507
[Book] 内分泌・糖尿病・代謝内科2012
- Author(s)
  小林俊寛, 中内啓光
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-23700507
[Book] 細胞工学、異種間キメラ作製技術と臓器再生への応用2012
- Author(s)
  小林俊寛, 中内啓光
- Data Source
  KAKENHI-PROJECT-23700507
[Book] 多能性幹細胞を用いてマウスの体内にラットの膵臓を形成させるGeneration of Rat Pancreas in Mouse2011
- Author(s)
  小林俊寛, 中内啓光
- Publisher
  Medical Science Digest
- Data Source
  KAKENHI-PROJECT-23700507
[Book] 生物の科学遺伝、マウス生体内にラットの膵臓を作製2011
- Author(s)
  小林俊寛,中内啓光
- Data Source
  KAKENHI-PROJECT-23700507
[Journal Article] Multiple ageing effects on testicular/epididymal germ cells lead to decreased male fertility in mice2024
- Author(s)
  Tsutomu Endo, Kiyonori Kobayashi, Takafumi Matsumura, Chihiro Emori, Manabu Ozawa, Shimpei Kawamoto, Daisuke Okuzaki, Keisuke Shimada, Haruhiko Miyata, Kentaro Shimada, Mayo Kodani, Yu Ishikawa-Yamauchi, Daisuke Motooka, Eiji Hara, Masahito Ikawa
- Journal Title
  
  Communications Biology
  
  Volume: 7(1) Issue: 1 Pages: 1-6
- DOI
  10.1038/s42003-023-05685-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14456, KAKENHI-PROJECT-23K20043, KAKENHI-PROJECT-23K05587, KAKENHI-PROJECT-23K06481, KAKENHI-PROJECT-20H03162, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-21H05033, KAKENHI-PROJECT-23K27084
[Journal Article] Generation of Tfap2c‐T2A‐tdTomato knock‐in reporter rats via adeno‐associated virus‐mediated efficient gene targeting2022
- Author(s)
  Oikawa Mami、Nagae Mayuko、Mizuno Naoaki、Iwatsuki Kenyu、Yoshida Fumika、Inoue Naoko、Uenoyama Yoshihisa、Tsukamura Hiroko、Nakauchi Hiromitsu、Hirabayashi Masumi、Kobayashi Toshihiro
- Journal Title
  
  Molecular Reproduction and Development
  
  Volume: 89 Issue: 3 Pages: 129-132
- DOI
  10.1002/mrd.23562
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05548, KAKENHI-PROJECT-20H03167, KAKENHI-PROJECT-21K19186, KAKENHI-PROJECT-21H05031, KAKENHI-PROJECT-20H03127
[Journal Article] Dual role of <i>Ovol2</i> on the germ cell lineage segregation during gastrulation in mouse embryogenesis2022
- Author(s)
  Naitou Yuki、Nagamatsu Go、Hamazaki Nobuhiko、Shirane Kenjiro、Hayashi Masafumi、Hayashi Makoto、Kobayashi Satoru、Hayashi Katsuhiko
- Journal Title
  
  Development
  
  Volume: 149 Issue: 4 Pages: 1-13
- DOI
  10.1242/dev.200319
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05545, KAKENHI-PROJECT-19J20553, KAKENHI-PROJECT-22K15125, KAKENHI-ORGANIZER-18H05544, KAKENHI-PLANNED-18H05552
[Journal Article] Blastocyst complementation using Prdm14-deficient rats enables efficient germline transmission and generation of functional mouse spermatids in rats2021
- Author(s)
  Toshihiro Kobayashi, Teppei Goto, Mami Oikawa, Makoto Sanbo, Fumika Yoshida, Reiko Terada, Naoko Niizeki, Naoyo Kajitani, Kanako Kazuki, Yasuhiro Kazuki, Shinichi Hochi, Hiromitsu Nakauchi, M. Azim Surani & Masumi Hirabayashi
- Journal Title
  
  Nature Comminications
  
  Volume: 12 Issue: 1 Pages: 13281-10
- DOI
  10.1038/s41467-021-21557-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06364, KAKENHI-ORGANIZER-18H05544, KAKENHI-PROJECT-18H02367, KAKENHI-PROJECT-19K16270, KAKENHI-PROJECT-19K23711, KAKENHI-PLANNED-18H05548, KAKENHI-PROJECT-20H03167
[Journal Article] Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells2021
- Author(s)
  Kobayashi Toshihiro、Castillo-Venzor Aracely、Penfold Chris A.、Morgan Michael、Mizuno Naoaki、Tang Walfred W.C.、Osada Yasuyuki、Hirao Masao、Yoshida Fumika、Sato Hideyuki、Nakauchi Hiromitsu、Hirabayashi Masumi、Surani M. Azim
- Journal Title
  
  Cell Reports
  
  Volume: 37 Issue: 2 Pages: 109812-109812
- DOI
  10.1016/j.celrep.2021.109812
- Data Source
  KAKENHI-PLANNED-18H05548, KAKENHI-PROJECT-20H03167
[Journal Article] Direct evidence that KNDy neurons maintain gonadotropin pulses and folliculogenesis as the GnRH pulse generator2021
- Author(s)
  Nagae Mayuko、Uenoyama Yoshihisa、Okamoto Saki、Tsuchida Hitomi、Ikegami Kana、Goto Teppei、Majarune Sutisa、Nakamura Sho、Sanbo Makoto、Hirabayashi Masumi、Kobayashi Kenta、Inoue Naoko、Tsukamura Hiroko
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 5
- DOI
  10.1073/pnas.2009156118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15650, KAKENHI-PROJECT-18H03973, KAKENHI-PROJECT-18H02367, KAKENHI-PROJECT-20H03127, KAKENHI-PROJECT-18K06535, KAKENHI-PROJECT-19K16270, KAKENHI-PROJECT-19H03103
[Journal Article] Conserved features of non-primate bilaminar disc embryos and the germline2021
- Author(s)
  Alberio Ramiro、Kobayashi Toshihiro、Surani M. Azim
- Journal Title
  
  Stem Cell Reports
  
  Volume: 16 Issue: 5 Pages: 1078-1092
- DOI
  10.1016/j.stemcr.2021.03.011
- Data Source
  KAKENHI-PLANNED-18H05548, KAKENHI-PROJECT-20H03167
[Journal Article] Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species2021
- Author(s)
  Kinoshita Masaki、Kobayashi Toshihiro、Planells Benjamin、Klisch Doris、Spindlow Daniel、Masaki Hideki、Bornelv Susanne、Stirparo Giuliano Giuseppe、Matsunari Hitomi、Uchikura Ayuko、Lamas-Toranzo Ismael、Nichols Jennifer、Nakauchi Hiromitsu、Nagashima Hiroshi、Alberio Ramiro、Smith Austin
- Journal Title
  
  Development
  
  Volume: 148 Issue: 23
- DOI
  10.1242/dev.199901
- Data Source
  KAKENHI-PLANNED-18H05548, KAKENHI-PROJECT-20H03167
[Journal Article] Absence of X-chromosome dosage compensation in the primordial germ cells of Drosophila embryos2021
- Author(s)
  Ota Ryoma、Hayashi Makoto、Morita Shumpei、Miura Hiroki、Kobayashi Satoru
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 4890-4890
- DOI
  10.1038/s41598-021-84402-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-18H05544, KAKENHI-PROJECT-20H03287, KAKENHI-PLANNED-18H05552
[Journal Article] Germline development in rat revealed by visualization and deletion of Prdm142020
- Author(s)
  Kobayashi Toshihiro、Kobayashi Hisato、Goto Teppei、Takashima Tomoya、Oikawa Mami、Ikeda Hiroki、Terada Reiko、Yoshida Fumika、Sanbo Makoto、Nakauchi Hiromitsu、Kurimoto Kazuki、Hirabayashi Masumi
- Journal Title
  
  Development
  
  Volume: 147 Pages: 183798-183798
- DOI
  10.1242/dev.183798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19295, KAKENHI-PROJECT-19K23711, KAKENHI-ORGANIZER-18H05544, KAKENHI-PLANNED-18H05553, KAKENHI-PROJECT-18H02367, KAKENHI-PLANNED-18H05548
[Journal Article] Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism2019
- Author(s)
  Kazuki Yasuhiro、Kobayashi Kaoru、他23名
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 116 Issue: 8 Pages: 3072-3081
- DOI
  10.1073/pnas.1808255116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04285, KAKENHI-PROJECT-18H02367, KAKENHI-PROJECT-18H03974
[Journal Article] Establishment of porcine and human expanded potential stem cells2019
- Author(s)
  Xuefei Gao, Monika Nowak-Imialek, Xi Chen, Dongsheng Chen, Doris Herrmann, Degong Ruan, Andy Chun Hang Chen, Melanie A Eckersley-Maslin, Shakil Ahmad, Yin Lau Lee, Toshihiro Kobayashi, et al
- Journal Title
  
  Nature Cell Biology
  
  Volume: 21 Issue: 6 Pages: 687-699
- DOI
  10.1038/s41556-019-0333-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05548
[Journal Article] Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats2019
- Author(s)
  Goto Teppei、Hara Hiromasa、Sanbo Makoto、Masaki Hideki、Sato Hideyuki、Yamaguchi Tomoyuki、Hochi Shinichi、Kobayashi Toshihiro、Nakauchi Hiromitsu、Hirabayashi Masumi
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 451-451
- DOI
  10.1038/s41467-019-08394-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07985, KAKENHI-PROJECT-18H02367, KAKENHI-PLANNED-18H05548
[Journal Article] Targeted DamID reveals differential binding of mammalian pluripotency factors2018
- Author(s)
  Cheetham Seth W.、Gruhn Wolfram H.、van den Ameele Jelle、Krautz Robert、Southall Tony D.、Kobayashi Toshihiro、Surani M. Azim、Brand Andrea H.
- Journal Title
  
  Development
  
  Volume: 145 Issue: 20 Pages: 1-11
- DOI
  10.1242/dev.170209
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05548
[Journal Article] Tracing the transitions from pluripotency to germ cell fate with CRISPR screening2018
- Author(s)
  Hackett Jamie A.、Huang Yun、G?nesdogan Ufuk、Gretarsson Kristjan A.、Kobayashi Toshihiro、Surani M. Azim
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 1-12
- DOI
  10.1038/s41467-018-06230-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05548
[Journal Article] Chimeric liver transplantation reveals interspecific graft remodelling.2018
- Author(s)
  Oldani G, Peloso A, Vijgen S, Wilson EM, Slits F, Gex Q, Morel P, Delaune V, Orci LA, Yamaguchi T, Kobayashi T, Rubbia-Brandt L, Nakauchi H, Lacotte S, Toso C.
- Journal Title
  
  J Hepatol.
  
  Volume: 69(5) Issue: 5 Pages: 1025-1036
- DOI
  10.1016/j.jhep.2018.07.008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08623, KAKENHI-PLANNED-18H05548
[Journal Article] On the origin of the human germline2018
- Author(s)
  Kobayashi Toshihiro、Surani M. Azim
- Journal Title
  
  Development
  
  Volume: 145 Issue: 16 Pages: 1-4
- DOI
  10.1242/dev.150433
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05548
[Journal Article] An interspecies barrier to tetraploid complementation and chimera formation2018
- Author(s)
  Yamaguchi Tomoyuki、Sato Hideyuki、Kobayashi Toshihiro、Kato-itoh Megumi、Goto Teppei、Hara Hiromasa、Mizuno Naoaki、Yanagida Ayaka、Umino Ayumi、Hamanaka Sanae、Suchy Fabian、Masaki Hideki、Ota Yasunori、Hirabayashi Masumi、Nakauchi Hiromitsu
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 15289-15298
- DOI
  10.1038/s41598-018-33690-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10536, KAKENHI-PROJECT-18H02367, KAKENHI-PLANNED-18H05548
[Journal Article] Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation.2018
- Author(s)
  Hamanaka S, Umino A, Sato H, Hayama T, Yanagida A, Mizuno N, Kobayashi T, Kasai M, Suchy FP, Yamazaki S, Masaki H, Yamaguchi T, Nakauchi H.
- Journal Title
  
  Stem Cell Reports.
  
  Volume: 11(4) Issue: 4 Pages: 988-997
- DOI
  10.1016/j.stemcr.2018.08.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08623, KAKENHI-PROJECT-17K10536, KAKENHI-PUBLICLY-18H05095, KAKENHI-PROJECT-16H02661, KAKENHI-PROJECT-17H05086, KAKENHI-PLANNED-18H05548
[Journal Article] Derivation of hypermethylated pluripotent embryonic stem cells with high potency2017
- Author(s)
  Bao Siqin、Tang Walfred WC、Wu Baojiang、Kim Shinseog、Li Jingyun、Li Lin、Kobayashi Toshihiro、Lee Caroline、Chen Yanglin、Wei Mengyi、Li Shudong、Dietmann Sabine、Tang Fuchou、Li Xihe、Surani M Azim
- Journal Title
  
  Cell Research
  
  Volume: 28 Issue: 1 Pages: 22-34
- DOI
  10.1038/cr.2017.134
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H07339
[Journal Article] Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs.2013
- Author(s)
  Matsunari H, Nagashima H, Watanabe M, Umeyama K, Nakano K, Nagaya M, Kobayashi T, Yamaguchi T, Sumazaki R, Herzenberg LA, Nakauchi H.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 110(12) Pages: 4557-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700507
[Journal Article] A retrospective analysis of germline competence in rat embryonic stem cell lines.2013
- Author(s)
  Hirabayashi M, Tamura C, Sanbo M, Kato-Itoh M, Kobayashi T, Nakauchi H, Hochi S.
- Journal Title
  
  Transgenic Res.
  
  Volume: 22(2) Pages: 411-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700507
[Journal Article] Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.2012
- Author(s)
  Yamaguchi T, Hamanaka S, Kamiya A, Okabe M, Kawarai M, Wakiyama Y, Umino A, Hayama T, Sato H, Lee YS, Kato-Itoh M, Masaki H, Kobayashi T, Yamazaki S, Nakauchi H.
- Journal Title
  
  PLoS One.
  
  Volume: 7(7)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700507
[Journal Article] Development of an All-in-One Inducible Lentiviral Vector for Gene Specific Analysis of Reprogramming.2012
- Author(s)
  Yamaguchi T, Hamanaka S, Kamiya A, Okabe M, Kawarai M, Wakiyama Y, Umino A, Hayama T, Sato H, Lee YS, Kato-Itoh M, Masaki H, Kobayashi T, Yamazaki S, Nakauchi H.
- Journal Title
  
  PLoS One.
  
  Volume: 7 Issue: 7 Pages: e41007-e41007
- DOI
  10.1371/journal.pone.0041007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689040, KAKENHI-PROJECT-23700507, KAKENHI-PROJECT-24249056, KAKENHI-PLANNED-23106004, KAKENHI-PUBLICLY-24112505
[Journal Article] Generation of kidney from pluripotent stem cells via blastocyst complementation.2012
- Author(s)
  Usui J, Kobayashi T, Yamaguchi T, Knisely AS, Nishinakamura R, Nakauchi H.
- Journal Title
  
  Am J Pathol
  
  Volume: 180(6) Pages: 2417-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700507
[Journal Article] Identification of rat Rosa26 locus enables generation of knock-in rat lines ubiquitously expressing tdTomato.2012
- Author(s)
  Kobayashi T, Kato-Itoh M, Yamaguchi T, Tamura C, Sanbo M, Hirabayashi M, Nakauchi H.
- Journal Title
  
  Stem Cells Dev.
  
  Volume: 21(16) Pages: 2981-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700507
[Journal Article] Ability of tetraploid rat blastocysts to support fetal development after complementation with embryonic stem cells2012
- Author(s)
  Hirabayashi M
- Journal Title
  
  Molecular Reproduction and Development
  
  Volume: 79 Issue: 6 Pages: 402-412
- DOI
  10.1002/mrd.22043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300147, KAKENHI-PROJECT-23700507, KAKENHI-PLANNED-23106004
[Journal Article] Ability of tetraploid rat blastocysts to support fetal development after complementation with embryonic stem cells.2012
- Author(s)
  Hirabayashi M, Tamura C, Sanbo M, Goto T, Kato-Itoh M, Kobayashi T, Nakauchi H, Hochi S.
- Journal Title
  
  Mol Reprod Dev.
  
  Volume: 79(6) Pages: 402-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700507
[Journal Article] From cell therapy to organ regeneration therapy: generation of functional organs from pluripotent stem cells2011
- Author(s)
  Nakauchi H. and Kobayashi T.
- Journal Title
  
  Nihon Rinsho
  
  Volume: 69(12) Pages: 2148-55
- NAID
  40019080103
- Data Source
  KAKENHI-PROJECT-23700507
[Journal Article] Generation of germline-competent rat induced pluripotent stem cells.2011
- Author(s)
  Hamanaka S, Yamaguchi T, Kobayashi T,Kato-Itoh M, Yamazaki S, Sato H, Umino A, Wakiyama Y, Arai M, Sanbo M, Hirabayashi M, Nakauchi H.
- Journal Title
  
  PLoS One.
  
  Volume: 6(7)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700507
[Journal Article] Generation of germline-competent rat induced pluripotent stem cells2011
- Author(s)
  Hamanaka S
- Journal Title
  
  PLoS ONE
  
  Volume: 6 Issue: 7 Pages: e22008-e22008
- DOI
  10.1371/journal.pone.0022008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300147, KAKENHI-PROJECT-22659058, KAKENHI-PROJECT-23700507
[Journal Article] From cell therapy to organ regeneration therapy: generation of functional organs from pluripotent stem cells2011
- Author(s)
  Kobayashi T, Nakauchi H
- Journal Title
  
  Nihon Rinsho.
  
  Volume: 69(12) Pages: 2148-2148
- NAID
  40019080103
- Data Source
  KAKENHI-PROJECT-23700507
[Presentation] ラット多能性幹細胞からの機能的な生殖細胞作製2022
- Author(s)
  小林俊寛
- Organizer
  第15回ラットリソース・リサーチ研究会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05548
[Presentation] 乗り越えろ！異種の壁～初期胚・生殖細胞発生からみた哺乳類間の類似点と相違点～2022
- Author(s)
  小林俊寛
- Organizer
  The 81st Scienc-ome
- Invited
- Data Source
  KAKENHI-PROJECT-20H03167
[Presentation] 乗り越えろ！異種の壁～初期胚・生殖細胞発生からみた哺乳類間の類似点と相違点～2022
- Author(s)
  小林俊寛
- Organizer
  The 81st Scienc-ome
- Invited
- Data Source
  KAKENHI-PLANNED-18H05548
[Presentation] ラット多能性幹細胞からの機能的な生殖細胞作製2022
- Author(s)
  小林俊寛
- Organizer
  第15回ラットリソース・リサーチ研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03167
[Presentation] In vitro Reconstitution of Germline Development in Rats2022
- Author(s)
  Toshihiro Kobayashi
- Organizer
  IMSUT International Joint Usage/Research Center-Young Researchers Symposium
- Invited
- Data Source
  KAKENHI-PLANNED-18H05548
[Presentation] In vivo および in vitro におけるラット多能性幹細胞からの生殖細胞誘導2022
- Author(s)
  小林俊寛
- Organizer
  日本再生医療学会総会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05548
[Presentation] In vitro Reconstitution of Germline Development in Rats2022
- Author(s)
  Toshihiro Kobayashi
- Organizer
  IMSUT International Joint Usage/Research Center-Young Researchers Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-20H03167
[Presentation] In vivo および in vitro におけるラット多能性幹細胞からの生殖細胞誘導2022
- Author(s)
  小林俊寛
- Organizer
  日本再生医療学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03167
[Presentation] ラット Naive 型多能性幹細胞におけるゲノムインプリンティング消去回避の試み2021
- Author(s)
  岩月研祐, 及川真実, 小林久人, 栗本一基, 平林真澄, 小林俊寛
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H03167
[Presentation] Blastocyst complementation using Prdm14-deficient rats for robust germline transmission2021
- Author(s)
  Toshihiro Kobayashi, Teppei Goto, Mami Oikawa, Makoto Sanbo, Yasuhiro Kazuki, Hiromitsu Nakauchi, Azim M Surani, Masumi Hirabayashi
- Organizer
  第18回幹細胞シンポジウム
- Data Source
  KAKENHI-PLANNED-18H05548
[Presentation] ラット多能性幹細胞からの機能的な始原生殖細胞の分化誘導2021
- Author(s)
  及川真実, 小林久人, 三宝誠, 水野直彬, 岩月研祐, 山内恵子, 吉田史香, 山本拓也, 篠原隆司, 中内啓光, 栗本一基, 平林真澄, 小林俊寛
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H03167
[Presentation] 胚盤胞補完法とその遺伝子改変動物作製への応用2021
- Author(s)
  小林俊寛
- Organizer
  第94回日本生化学会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05548
[Presentation] ラット Naive 型多能性幹細胞におけるゲノムインプリンティング消去回避の試み2021
- Author(s)
  岩月研祐, 及川真実, 小林久人, 栗本一基, 平林真澄, 小林俊寛
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-18H05548
[Presentation] Blastocyst complementation using Prdm14-deficient rats for robust germline transmission2021
- Author(s)
  Toshihiro Kobayashi, Teppei Goto, Mami Oikawa, Makoto Sanbo, Yasuhiro Kazuki, Hiromitsu Nakauchi, Azim M Surani, Masumi Hirabayashi
- Organizer
  第18回幹細胞シンポジウム
- Data Source
  KAKENHI-PROJECT-20H03167
[Presentation] ラット多能性幹細胞からの機能的な始原生殖細胞の分化誘導2021
- Author(s)
  及川真実, 小林久人, 三宝誠, 水野直彬, 岩月研祐, 山内恵子, 吉田史香, 山本拓也, 篠原隆司, 中内啓光, 栗本一基, 平林真澄, 小林俊寛
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-18H05548
[Presentation] 胚盤胞補完法とその遺伝子改変動物作製への応用2021
- Author(s)
  小林俊寛
- Organizer
  第94回日本生化学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03167
[Presentation] Conservation and diversity of germline development in mammals2020
- Author(s)
  Toshihiro Kobayashi
- Organizer
  1st CU- KU Symposium and 4th CU-NIPS Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05548
[Presentation] Conservation and diversity of germline development in mammals2020
- Author(s)
  KOBAYASHI, Toshihiro
- Organizer
  1st CU- KU Symposium and 4th CU-NIPS Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-18H05544
[Presentation] 円盤状胚盤を形成する哺乳類から樹立した多能性幹細胞とその利用2020
- Author(s)
  小林俊寛
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05548
[Presentation] 円盤状胚盤を形成する哺乳類から樹立した多能性幹細胞とその利用2020
- Author(s)
  小林俊寛
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03167
[Presentation] アデノ随伴ウイルスベクター法を介した効率的なTfap2c-T2A-tdTomatoノックインラット作製とその発現解析2020
- Author(s)
  長江麻佑子, 及川真実，水野直彬, 岩月研祐, 三宝誠, 中内啓光,平林真澄，小林俊寛
- Organizer
  第67回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-18H02367
[Presentation] Generation of organs from pluripotent stem cells via blastocyst complementation2019
- Author(s)
  Toshihiro Kobayashi
- Organizer
  2019 Korea-Yonsei-NIPS International Joint Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05548
[Presentation] 胚発生過程を利用した目的臓器の再生2019
- Author(s)
  小林俊寛
- Organizer
  日本動物学会第90回大阪大会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05548
[Presentation] ショウジョウバエ生殖系列の品質管理機構2019
- Author(s)
  小林覚
- Organizer
  第91回日本遺伝学会
- Data Source
  KAKENHI-ORGANIZER-18H05544
[Presentation] Prdm14遺伝子をノックアウトしたラット性腺の免疫組織学的解析2019
- Author(s)
  平林真澄，後藤哲平，三宝誠, 保地眞一, 中内啓光, 小林俊寛
- Organizer
  第66回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-18H02367
[Presentation] Prdm14遺伝子ノックアウトによる生殖細胞欠損ラットの作製とその応用2019
- Author(s)
  平林真澄，後藤哲平，三宝誠, 保地眞一, 中内啓光, 小林俊寛
- Organizer
  第112回日本繁殖生物学会
- Data Source
  KAKENHI-PROJECT-18H02367
[Presentation] 哺乳類の生殖細胞成立機構における保存性と多様性2019
- Author(s)
  小林俊寛
- Organizer
  中部幹細胞クラブシンポジウム 2019
- Invited
- Data Source
  KAKENHI-PLANNED-18H05548
[Presentation] Prdm14 遺伝子座に H2BVeunus をノックインしたラットにおける始原生殖細胞発生の解析2019
- Author(s)
  小林俊寛
- Organizer
  第66回日本実験動物学会
- Data Source
  KAKENHI-PLANNED-18H05548
[Presentation] Prdm14 遺伝子座に H2BVeunus をノックインしたラットにおける始原生殖細胞発生の解析2019
- Author(s)
  小林俊寛，小林久人，後藤哲平，及川真実，三宝誠，中内啓光，栗本一基，平林真澄
- Organizer
  第66回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-18H02367
[Presentation] 多能性幹細胞とモデル動物を用いてヒト生殖細胞の起源を探る2018
- Author(s)
  小林俊寛
- Organizer
  第34回日本霊長類学会大会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05548
[Presentation] ヒト初期発生、とくに生殖細胞への運命決定機構の解明に向けた複合的アプローチ2018
- Author(s)
  小林俊寛
- Organizer
  第111回日本繁殖生物学会大会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05548
[Presentation] ヒト初期発生、とくに生殖細胞への運命決定機構の解明に向けた複合的アプローチ2018
- Author(s)
  小林　俊寛
- Organizer
  第21回日本異種移植研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02367
[Presentation] Principles of early human development and germ cell program from in　vivo and in vitro models.2017
- Author(s)
  Kobayashi T, Hirabayashi M, Alberio R, Surani MA.
- Organizer
  CiRA 2017 International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H07339
[Presentation] ヒト ES 細胞から始原生殖細胞への分化誘導法2017
- Author(s)
  小林俊寛, 平林真澄, Ramiro Alberio, Azim M Surani.
- Organizer
  第35回動物生殖工学研究会
- Data Source
  KAKENHI-PROJECT-17H07339
[Presentation] ラットRosa26遺伝子座の同定と全身性にtdTomato遺伝子を発現するノックインラットの作製2012
- Author(s)
  小林俊寛,加藤-伊藤めぐみ,山口智之,田村千尋,三宝誠,平林真澄,中内啓光
- Organizer
  第59回日本実験動物学会総会
- Year and Date
  2012-05-26
- Data Source
  KAKENHI-PROJECT-23700507
[Presentation] GENERATION OF ROSA26-TDTOMATO KNOCK-IN RATS VIA GENE TARGETING OF PLURIPOTENT STEM CELLS2012
- Author(s)
  Toshihiro Kobayashi, Megumi Kato-Itoh, Tomoyuki Yamaguchi, Chihiro Tamura, Makoto Sanbo, Masumi Hirabayashi, and Hiromitsu Nakauchi
- Organizer
  10th International Society of Stem Cell Research
- Place of Presentation
  横浜
- Year and Date
  2012-06-15
- Data Source
  KAKENHI-PROJECT-23700507
[Presentation] ラットRosa26遺伝子座の同定と全身性にtdTomato遺伝子を発現するノックインラットの作製2012
- Author(s)
  小林俊寛, 加藤-伊藤めぐみ, 山口智之, 田村千尋, 三宝誠, 平林真澄, 中内啓光
- Organizer
  第59回日本実験動物学会総会
- Place of Presentation
  別府・大分
- Year and Date
  2012-05-26
- Data Source
  KAKENHI-PROJECT-23700507
[Presentation] Generation of Embryos by Interspecific Tetraploid Complementation Using Mouse and Rat Pluripotent Stem Cells2012
- Author(s)
  Megumi Kato, Toshihiro Kobayashi, Tomoyuki Yamaguchi, Chihiro Tamura, Makoto Sanbo, Masumi Hirabayashi, Hiromitsu Nakauchi
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  博多・福岡
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-23700507
[Presentation] GENERATION OF ROSA26-TDTOMATO KNOCK-IN RATS VIA GENETARGETING OF PLURIPOTENT STEM CELLS2012
- Author(s)
  Toshihiro Kobayashi, Megumi Kato-Itoh, Tomoyuki Yamaguchi, Chihiro Tamura, Makoto Sanbo, Masumi Hirabayashi, Hiromitsu Nakauchi
- Organizer
  10^<th> Internal Society of Stem Cell Research
- Place of Presentation
  横浜・神奈川
- Year and Date
  2012-06-14
- Data Source
  KAKENHI-PROJECT-23700507
[Presentation] iPS細胞由来の臓器再生を目指して-マウス体内でラットの膵臓作製-2011
- Author(s)
  小林俊寛
- Organizer
  第1回細胞再生研究会プログラム
- Year and Date
  2011-07-31
- Data Source
  KAKENHI-PROJECT-23700507
[Presentation] マウス体内にラット iPS 細胞由来の膵臓を作製2011
- Author(s)
  小林俊寛, 中内啓光
- Organizer
  Liver 2011(招待講演)
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23700507
[Presentation] iPS 細胞由来の臓器再生を目指して -マウス体内でラットの膵臓作製-2011
- Author(s)
  小林俊寛
- Organizer
  第 1 回細胞再生研究会プログラム(招待講演)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23700507
[Presentation] Generation of Rat Embryo in Mouse by Tetraploid Complementation Using Pluripotent Stem Cells2011
- Author(s)
  Toshihiro Kobayashi, Megumi Kato-Itoh, Tomoyuki Yamaguchi, Sanae Hamanaka, Masumi Hirabayashi and Hiromitsu Nakauchi
- Organizer
  9th Internal Society of Stem Cell Research
- Place of Presentation
  トロント，カナダ
- Data Source
  KAKENHI-PROJECT-23700507
[Presentation] マウス体内にラットiPS細胞由来の膵臓を作製2011
- Author(s)
  小林俊寛
- Organizer
  Liver2011第7回肝免疫・ウイルス・フロンティア
- Year and Date
  2011-07-09
- Data Source
  KAKENHI-PROJECT-23700507
[Presentation] Generation of Rat Pancreas in Mouse via Interspecific Blastocyst Complementation2011
- Author(s)
  Toshihiro Kobayashi, Hiromitsu Nakauchi
- Organizer
  第54回日本糖尿病学会総会(招待講演)
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-23700507
[Presentation] マウス-ラット異種間キメラの作製と再生医療への応用2011
- Author(s)
  小林俊寛,中内啓光
- Organizer
  第58回日本実験動物学会総会
- Year and Date
  2011-05-27
- Data Source
  KAKENHI-PROJECT-23700507
[Presentation] ES/iPS細胞を用いた発生工学と臓器再生への応用2011
- Author(s)
  小林俊寛
- Organizer
  Advans研究会2011
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-23700507
[Presentation] GENERATION OF RAT EMBRYO IN MOUSE BY TETRAPLOID COMPLEMENTATION USING PLURIPOTENT STEM CELLS2011
- Author(s)
  Kobayashi, Toshihiro, Kato-Itoh, Megumi, Yamaguchi, Tomoyuki, Hamanaka, Sanae, Hirabayashi, Masumi, Nakauchi, Hiromitsu
- Organizer
  9th International Society of Stem Cell Research (カナダ・トロント)
- Year and Date
  2011-06-17
- Data Source
  KAKENHI-PROJECT-23700507
[Presentation] Generation of Rat Pancreas in Mouse via Interspecific Blastocyst Complementation Using Pluripotent Stem Cells2011
- Author(s)
  小林俊寛,中内啓光
- Organizer
  第54回日本糖尿病学会総会
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-23700507
[Presentation] マウス-ラット異種間キメラの作製と臓器再生への応用2011
- Author(s)
  小林俊寛, 中内啓光
- Organizer
  第58回日本実験動物学会総会(招待講演)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23700507
[Presentation] ES/iPS 細胞を用いた発生工学と臓器再生への応用2011
- Author(s)
  小林俊寛
- Organizer
  Advans 研究会(招待講演)
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23700507

1. HIRABAYASHI Masumi (20353435)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. HAYASHI Katsuhiko (20287486)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 長嶋比呂志 (50318664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 北島智也 (00376641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 栗本一基 (20415152)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 中村隼明 (30613723)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 木村啓志 (40533625)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 吉田松生 (60294138)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 吉崎悟朗 (70281003)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 尾畑やよい (70312907)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 小林悟 (90225508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. 伊川正人 (20304066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 篠原隆司 (30322770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 三浦恭子 (80583062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KAZUKI Yasuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. YAMAGUCHI Tomoyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 保地眞一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 紙谷聡英

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 中村翔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 山内祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 濱仲早苗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOBAYASHI Toshihiro 小林 俊寛

Kobayashi Toshihiro 小林 俊寛

Research Projects

Research Products

Co-Researchers

Establishment of tetraploid complementation competent pluripotent stem cells in ratsPrincipal Investigator

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Next-generation ART: Building a global network to create innovative technologies in m ammalian reproductive engineering

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Genetic analysis of primordial germ cell using pig epiblast stem cells and cloned embryosPrincipal Investigator

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Developmental analysis of xenogenic germ cells using blastocyst complementation

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Adaptation of in vitro gametogenesis across a wide range of speciesPrincipal Investigator

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目的臓器作出に向けた一胚葉特異的なキメラ作製法の開発Principal Investigator

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Ensuring integrity of gametogenesis

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ウサギES細胞からの始原生殖細胞誘導法とそれを用いた生殖系列キメラ作製法の開発Principal Investigator

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Generate pluripotent stem cell derived animals by using interspecific blastocyst complementationPrincipal Investigator

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[Book] 肝胆膵2012

Author(s)

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[Book] 内分泌・糖尿病・代謝内科2012

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[Book] 細胞工学、異種間キメラ作製技術と臓器再生への応用2012

Author(s)

Data Source

[Book] 多能性幹細胞を用いてマウスの体内にラットの膵臓を形成させるGeneration of Rat Pancreas in Mouse2011

Author(s)

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[Book] 生物の科学遺伝、マウス生体内にラットの膵臓を作製2011

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[Journal Article] Multiple ageing effects on testicular/epididymal germ cells lead to decreased male fertility in mice2024

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Journal Title

KOBAYASHI Toshihiro 小林俊寛

Kobayashi Toshihiro 小林俊寛