Ito Sumito 伊藤澄人

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伊藤澄人イトウスミト

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Researcher Number	20728969
Affiliation (Current)	2025: 株式会社ジェノメンブレン(研究部), 研究部, 取締役
Affiliation (based on the past Project Information) *help	2016: 株式会社ジェノメンブレン(研究部), 研究部, 研究員 2015 – 2016: 株式会社ジェノメンブレン(研究部), 基盤研究(S), 研究員 2014: 株式会社ジェノメンブレン(研究部), 研究部, 研究員
Review Section/Research Field	Except Principal Investigator Medical pharmacy
Keywords	Except Principal Investigator フェノタイピング / バーチャルクリニカルスタディ / 個人間変動 / 生理学的薬物速度論モデル / トランスポーター / 創薬支援システム / PET/SPECTプローブ / モデリング＆シミュレーション / 遺伝子多型 / 薬物間相互作用 / 薬物代謝酵素 / 薬物トランスポーター

Development of quantitative prediction methods for alteration in pharmacokinetics caused by interindividual variability in transporter function and transporter-mediated drug-drug interaction
- Principal Investigator
  
  Sugiyama Yuichi
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Medical pharmacy
- Research Institution
  Institute of Physical and Chemical Research

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Other

[Journal Article] Pharmacokinetic Modeling and Monte Carlo Simulation to Predict Interindividual Variability in Human Exposure to Oseltamivir and Its Active Metabolite, Ro 64-0802.2017
- Author(s)
  Ito M, Kusuhara K, Ose A, Kondo T, Tanabe K, Nakayama H, Horita S, Fujita T, Sugiyama Y.
- Journal Title
  
  AAPS J
  
  Volume: 19 Issue: 1 Pages: 286-297
- DOI
  10.1208/s12248-016-9992-0
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-26293032, KAKENHI-PROJECT-26460210
[Journal Article] Use of a physiologically based pharmacokinetic model for quantitative prediction of drug-drug interactions via CYP3A4 and estimation of the intestinal availability of CYP3A4 substrates.2015
- Author(s)
  Y. Mano, Y. Sugiyama, K. Ito
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 104 Issue: 9 Pages: 3183-3193
- DOI
  10.1002/jps.24495
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460209, KAKENHI-PROJECT-24229002
[Journal Article] Solute Carrier Family of the Organic Anion-Transporting Polypeptides 1A2- Madin-Darby Canine Kidney II: A Promising In Vitro System to Understand the Role of Organic Anion-Transporting Polypeptide 1A2 in Blood-Brain Barrier Drug Penetration.2015
- Author(s)
  Liu H, Yu N, Lu S, Ito S, Zhang X, Prasad B, He E, Lu X, Li Y, Wang F, Xu H, An G, Unadkat JD, Kusuhara H, Sugiyama Y, Sahi J.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 43 Issue: 7 Pages: 1008-18
- DOI
  10.1124/dmd.115.064170
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293032, KAKENHI-PROJECT-24229002
[Journal Article] Investigation of endogenous compounds for assessing the drug interactions in the urinary excretion involving multidrug and toxin extrusion proteins.2014
- Author(s)
  Kato K, Mori H, Kito T, Yokochi M, Ito S, Inoue K, Yonezawa A, Katsura T, Kumagai Y, Yuasa H, Moriyama Y, Inui K, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Pharmaceutical Research
  
  Volume: 31 Issue: 1 Pages: 136-147
- DOI
  10.1007/s11095-013-1144-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390138, KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-25670074
[Journal Article] Drugs interacting with organic anion transporter-1 affect uptake of Tc-99m-mercaptoacetyl-triglycine (MAG3) in the human kidney: therapeutic drug interaction in Tc-99m-MAG3 diagnosis of renal function and possible application of Tc-99m-MAG3 for drug development.2013
- Author(s)
  Takahara N, Saga T, Inubushi M, Kusuhara H, Seki C, Ito S, Oyama N, Yokoyama O, Sugiyama Y, Fujibayashi Y.
- Journal Title
  
  Nucl Med Biol
  
  Volume: 40 Issue: 5 Pages: 643-650
- DOI
  10.1016/j.nucmedbio.2013.03.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390239, KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-24659140, KAKENHI-PROJECT-24659559
[Journal Article] Relationship between the urinary excretion mechanisms of drugs and their physicochemical properties.2013
- Author(s)
  Ito S, Ando H, Ose A, Kitamura Y, Ando T, Kusuhara H, Sugiyama Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 102 Issue: 9 Pages: 3294-3301
- DOI
  10.1002/jps.23599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390034, KAKENHI-PROJECT-24229002
[Journal Article] Analysis of the repaglinide concentration increase produced by gemfibrozil and itraconazole based on the inhibition of the hepatic uptake transporter and metabolic enzymes.2013
- Author(s)
  Kudo T, Hisaka A, Sugiyama Y, Ito K.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 41 Issue: 2 Pages: 362-371
- DOI
  10.1124/dmd.112.049460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590204, KAKENHI-PROJECT-24229002
[Journal Article] Association of multidrug resistance-associated protein 2 single nucleotide polymorphism rs12762549 with the basal plasma levels of phase II metabolites of isoflavonoids in healthy Japanese individuals2012
- Author(s)
  Kato K, et al
- Journal Title
  
  Pharmacogenet Genomics
  
  Volume: 22 Issue: 5 Pages: 344-354
- DOI
  10.1097/fpc.0b013e3283517012
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23136101, KAKENHI-PROJECT-24229002
[Journal Article] Competitive Inhibition of the Luminal Efflux by Multidrug and Toxin Extrusions, but Not Basolateral Uptake by Organic Cation Transporter 2, Is the Likely Mechanism Underlying the Pharmacokinetic Drug-Drug Interactions Caused by Cimetidine in the Kidney2012
- Author(s)
  Ito S、Kusuhara H、Yokochi M、ToyoshimaJ、Inoue K、Yuasa H、Sugiyama Y
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 340巻 Issue: 2 Pages: 393-403
- DOI
  10.1124/jpet.111.184986
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008, KAKENHI-PROJECT-24229002
[Presentation] PBPK model of rifampicin incorporating its hepatic uptake and auto-induction processes to predict various types of DDIs such as CYP3A/2C9 inductions and OATPs inhibitions.2016
- Author(s)
  Asaumi R, Toshimoto K, Kudo T, Sawada T, Tobe Y, Kono K, Ito K, Nunoya K, Imawaka H, Sugiyama Y.
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-15
- Data Source
  KAKENHI-PROJECT-24229002
[]

1. Sugiyama Yuichi (80090471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 前田和哉 (00345258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 渡邊恭良 (40144399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 家入一郎 (60253473)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 吉門崇 (70535096)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 新垣友隆 (60643187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KUDO Toshiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 伊藤清美

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 佐賀恒夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 犬伏正幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 楠原洋之

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
12. 桂敏也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 米澤淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ito Sumito 伊藤 澄人

伊藤 澄人 イトウ スミト

Research Projects

Research Products

Co-Researchers

Development of quantitative prediction methods for alteration in pharmacokinetics caused by interindividual variability in transporter function and transporter-mediated drug-drug interaction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Pharmacokinetic Modeling and Monte Carlo Simulation to Predict Interindividual Variability in Human Exposure to Oseltamivir and Its Active Metabolite, Ro 64-0802.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Use of a physiologically based pharmacokinetic model for quantitative prediction of drug-drug interactions via CYP3A4 and estimation of the intestinal availability of CYP3A4 substrates.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Solute Carrier Family of the Organic Anion-Transporting Polypeptides 1A2- Madin-Darby Canine Kidney II: A Promising In Vitro System to Understand the Role of Organic Anion-Transporting Polypeptide 1A2 in Blood-Brain Barrier Drug Penetration.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Investigation of endogenous compounds for assessing the drug interactions in the urinary excretion involving multidrug and toxin extrusion proteins.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Drugs interacting with organic anion transporter-1 affect uptake of Tc-99m-mercaptoacetyl-triglycine (MAG3) in the human kidney: therapeutic drug interaction in Tc-99m-MAG3 diagnosis of renal function and possible application of Tc-99m-MAG3 for drug development.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Relationship between the urinary excretion mechanisms of drugs and their physicochemical properties.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of the repaglinide concentration increase produced by gemfibrozil and itraconazole based on the inhibition of the hepatic uptake transporter and metabolic enzymes.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of multidrug resistance-associated protein 2 single nucleotide polymorphism rs12762549 with the basal plasma levels of phase II metabolites of isoflavonoids in healthy Japanese individuals2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Competitive Inhibition of the Luminal Efflux by Multidrug and Toxin Extrusions, but Not Basolateral Uptake by Organic Cation Transporter 2, Is the Likely Mechanism Underlying the Pharmacokinetic Drug-Drug Interactions Caused by Cimetidine in the Kidney2012

Author(s)

Journal Title

DOI

Data Source

[Presentation] PBPK model of rifampicin incorporating its hepatic uptake and auto-induction processes to predict various types of DDIs such as CYP3A/2C9 inductions and OATPs inhibitions.2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[]

Ito Sumito 伊藤澄人

伊藤澄人イトウスミト