MANABE MOTOMU 眞鍋求

… Alternative Names

MANABE Motomu 真鍋求

真鍋求

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Researcher Number	30138309
Other IDs
Affiliation (Current)	2025: 秋田大学, 名誉教授, 名誉教授
Affiliation (based on the past Project Information) *help	2019: 秋田大学, 医学系研究科, 名誉教授 2018: 秋田大学, 医学系研究科, 教授 2011 – 2017: 秋田大学, 医学(系)研究科(研究院), 教授 2015: 秋田大学, 大学院医学系研究科, 教授 2009 – 2010: Akita University, 大学院・医学系研究科, 教授 … More 1998 – 2008: Akita University School of Medicine Department of Dermatology, Professor, 医学部, 教授 1995 – 1997: 順天堂大学, 医学部, 助教授 1993 – 1994: 順天堂大学, 医学部, 講師 1986: 順天堂大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Dermatology / Dermatology Except Principal Investigator Dermatology / Dermatology / Biomedical engineering/Biological material science
Keywords	Principal Investigator PTEN / PI3K / ケラチン / Stat3 / peptidylarginine deiminase / keratins / 角化細胞 / 癌抑制遺伝子 / 遺伝子改変マウス / 幹細胞 … More / メラノーマ / 皮膚悪性腫瘍 / 皮膚癌 / 創傷治癒 / 化学発癌 / シグナル伝達 / 有棘細胞癌 / プロテインキナーゼC / aPKC / 細胞極性 / molecular target-based therapy / SCC / 細胞骨格蛋白 / 癌遺伝子 / 再生医学 / 分子標的治療 / 扁平上皮癌 / Keratinocyte / Oncogenesis / Cowden disease / 皮膚腫瘍 / STAT3ノックアウトマウス / Ptenノックアウトマウス / 発癌 / Cowden病 / apoptosis / 表皮分化 / アポトーシス / タンパク質脱イミノ化酵素 / transfection / keratin diseases / 遺伝子導入 / ケラチン病 / KERATINOCYTE / TRANSFECTION / ANTI-SENSE RNA / STEROID SULFATASE / X-LINKED ICHTHYOSIS / steroid sulfatase / X-linked ichthyosis / antisense RNA / トランスフェクション / アンチセンスRNA / ステロイドサルファターゼ / 伴性遺伝性魚鱗癬 / 糖代謝 / INPP4B / Stat３ / ３次元培養法 / STAT３ / PＩ３K / サリノマイシン / 三酸化ヒ素 / スフェロイド / 細胞死 / 蛋白フォールディング / 分子シャペロン … More Except Principal Investigator 26Sプロテアソーム / 角化細胞 / ユビキチン / ケラチン病 / ケラチン / Shh / 遺伝子改変マウス / オートファージー / PipkIII / タモキシフェン / 空胞形成 / 細胞内小胞輸送 / PIPKIII / 細胞内小胞輸送系 / 炎症性皮膚疾患 / ノックアウトマウス / イノシトールリン脂質 / 壊疽性膿皮症 / 20S proteasome / Ubiquitin / Transfection / keratin disease / keratin / トランスフェクション / Ubiqutin / Keratin Disease / Filaggrin / Keratin / ユビチキン / フィラグリン / Bone regeneration / Mesenchyme / Cultured skin / Stem Cells / Liver regeneration / Tissue Engineering / 発毛促進 / 毛再生 / 骨再生 / 骨髄間葉系細胞 / 毛幹細胞 / 肝臓幹様細胞 / ケラチノサイト / フィーダー細胞 / 骨・軟骨再生 / 間葉系幹細胞 / 培養表皮 / 幹細胞 / 肝再生 / 再生医工学 / 先天性表皮水疱症の治療 / プロテアーゼインヒビターFOY-305 / プロテアーゼ / 発症機序 / 先天性表皮水疱症 Less

Molecular mechanism of skin cancer development by functional ambiguity of aPKC lamdaPrincipal Investigator
- Principal Investigator
  
  Manabe Motomu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Akita University
Role of INPP4B in melanoma development: possible effects of 3-BP as promising anticancer drugPrincipal Investigator
- Principal Investigator
  
  MANABE MOTOMU
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Akita University
Pathogenetic machanism for pyoderma gangrenosusm by disruption of the production pathway of phosphatidylinositol (3,5) biphosphate
- Principal Investigator
  
  Hasunuma Naoko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Akita University
Molecular basis of melanomagenesis based on the failure of pluripotency maintenance of melanocyte stem cellsPrincipal Investigator
- Principal Investigator
  
  MANABE Motomu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Akita University
Establishment of remodeling technologies for protein misfolding in keratin disorders using an inducible transgenic mouse modelPrincipal Investigator
- Principal Investigator
  
  MANABE Motomu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Akita University
Development of molecular target-based therapy of cutaneous squamous cell carcinoma by selective block of PI3K isoformsPrincipal Investigator
- Principal Investigator
  
  MANABE Motomu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Akita University
Roles for stat3 in carcinogenesis mouse model of Cowden diseasePrincipal Investigator
- Principal Investigator
  
  MANABE Motomu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Akita University
Study of pathophysiology of keratin disease
- Principal Investigator
  
  YONEDA Kozo
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  AKITA UNIVERSITY
Construction of keratin disease keratinocyte model
- Principal Investigator
  
  YONEDA Kozo
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  AKITA UNIVERSITY
Development of the artificial organs from human stem cells.
- Principal Investigator
  
  SUGIYAMA Toshihiro
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for University and Society Collaboration
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Akita University
Biological roles of peptidylarginine deiminase in the pathogenic mechanisms of keratin deseases : molecular biological approachPrincipal Investigator
- Principal Investigator
  
  MANABE Motomu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  AKITA UNIVERSITY
  Juntendo University
Effects of Mutant Keratin Genes in Transfected Epidermal Cells : Establishment of Cell Models for GenodermatosesPrincipal Investigator
- Principal Investigator
  
  MANABE Motomu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  JUNTENDO UNIVERSITY SCHOOL OF MEDICINE
Suppression of gene expression of steroid sulfatase by antisense RNA : Establishment of cellular model for X-linked ichthyosisPrincipal Investigator
- Principal Investigator
  
  MANABE Motomu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Juntendo University School of Medicine
先天性表皮水疱症の発症機序特に水疱惹起因子の同定とその活性制御機構について
- Principal Investigator
  
  高森建二
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Juntendo University

All 2019 2018 2017 2013 2008 2007 2006 2005 2004

All Journal Article Presentation

[Journal Article] Sox13 is a novel early marker for hair follicle development.2019
- Author(s)
  Noto M, Noguchi N, Ishimura A, Kiyonari H, Abe T, Suzuki T, Hasunuma N, Taira M, Manabe M, Osada SI.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 509 Issue: 4 Pages: 862-868
- DOI
  10.1016/j.bbrc.2018.12.163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16321, KAKENHI-PROJECT-18K08288, KAKENHI-PROJECT-17K10227
[Journal Article] Atypical protein kinase C isoforms differentially regulate directional keratinocyte migration during wound healing2019
- Author(s)
  Noguchi N, Hirose T, Suzuki T, Kagaya M, Chida K, Ohno S, Manabe M, Osada S
- Journal Title
  
  J Dermatol Sci
  
  Volume: 93 Issue: 2 Pages: 101-108
- DOI
  10.1016/j.jdermsci.2019.01.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10227, KAKENHI-PROJECT-18K08288
[Journal Article] Incidence rate of cutaneous squamous cell carcinoma is rapidly increasing in Akita Prefecture: Urgent alert for super-aged society2019
- Author(s)
  Umezono Y, Sato Y, Noto M, Yamada K, Noguchi N, Hasunuma N, Osada SI, Manabe M
- Journal Title
  
  J Dermatol
  
  Volume: 46 Issue: 3 Pages: 259-262
- DOI
  10.1111/1346-8138.14759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10227, KAKENHI-PROJECT-18K08288, KAKENHI-PROJECT-17K16321
[Journal Article] The cost burden of psoriasis treated with biologics in Akita prefecture2018
- Author(s)
  Mizusawa Y, Yamakawa T, Yamada K, Hasunuma N, Osada SI, Manabe M.
- Journal Title
  
  Akita J Med
  
  Volume: 45 Pages: 99-103
- NAID
  40021943273
- Data Source
  KAKENHI-PROJECT-17K10227
[Journal Article] Topical 3-bromopyruvate is a novel targeted therapy for melanoma in a preclinical model2018
- Author(s)
  Yamada M, Kagaya M, Noguchi N, Ueki S, Hasunuma N, Osada SI, Manabe M.
- Journal Title
  
  J Dermatol Sci
  
  Volume: 92 Issue: 2 Pages: 134-142
- DOI
  10.1016/j.jdermsci.2018.08.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10227, KAKENHI-PROJECT-18K08288, KAKENHI-PROJECT-15KK0329
[Journal Article] Skin grafting cases by negative pressure wound therapy for the treatment of skin tumors and intractable cutaneous ulcers2018
- Author(s)
  Tomura Y, Noto M, Yamada K, Hasunuma N, Osada SI, Manabe M
- Journal Title
  
  Akita J Med
  
  Volume: 45 Pages: 105-111
- NAID
  40021943294
- Data Source
  KAKENHI-PROJECT-17K10227
[Journal Article] Salinomycin sensitizes melanoma spheroids containing slow-cycling cells to the effects of arsenic trioxide2013
- Author(s)
  Ishikawa N,Takahashi M,Noguchi N,Manabe M
- Journal Title
  
  Akita J Med
  
  Volume: 40 Pages: 143-150
- NAID
  110009795628
- Data Source
  KAKENHI-PROJECT-23591612
[Journal Article] Salinomycin sensitizes melanoma spheroids containing slow-cycling cells to the effects of arsenic trioxide．2013
- Author(s)
  Ishikawa N，Takahashi M，Noguchi N，Manabe M．
- Journal Title
  
  Akita J Med
  
  Volume: 40 Pages: 143-150
- NAID
  110009795628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591612
[Journal Article] Trichoblastic infundibular cyst2006
- Author(s)
  Ansai, S., Tsuda, M., Nagato, H., Ni sh imaki, K., Wako, M., Manabe, M., Fukumoto, T., Kimura, T.
- Journal Title
  
  Am J Dermatopathol 28
  
  Pages: 507-509
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591231
[Journal Article] Collagen-PGA-hybrid matrix with bFGF accelerated angiogenesis and granulation tissue formation in diabetic mice2006
- Author(s)
  Nagato, H., Umebayashi, Y., Wako,M., Tabata, Y., Manabe, M.
- Journal Title
  
  J Dermatol 33
  
  Pages: 670-675
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591231
[Journal Article] A case of Arterio-venous Malformation with Neurofibromatosis-12006
- Author(s)
  Tsuda, M., Umebayashi, Y., Manabe, M., Demitsu, T., Ansai, S.
- Journal Title
  
  J Dermatol 33
  
  Pages: 158-159
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591231
[Journal Article] Possible spontaneous regression of a metastatic lesion of keratoacanthoma-like squamous cell carcinoma in a regional lymph node.2005
- Author(s)
  Ansai, S., Manabe, M.
- Journal Title
  
  J Dermatol 32
  
  Pages: 899-903
- NAID
  10020271816
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591087
[Journal Article] A Case of otomycosis by Aspergillus sclerotiorum2004
- Author(s)
  Harima, N., Inoue, T., Kubota, T., Okada, O., Ansai, S., Manabe, M., Ichinoe, M., Kasai,T.
- Journal Title
  
  J Dermatol 31
  
  Pages: 949-950
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591087
[Journal Article] The molecular basis of keratinizing Disorders2004
- Author(s)
  Manabe, M.
- Journal Title
  
  JMAJ 47
  
  Pages: 508-513
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591087
[Journal Article] A crucial autocrine/paracrine loop linking keratin 14 aggregates to TNFa-mediated cytotoxicity in epidermolysis bullosa simplex.2004
- Author(s)
  Yoneda, K., Furukawa, T., Zheng, Y-J., Momoi, T., Izawa, I., Inagaki, M., Manabe, M., Inagaki,N.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 7296-7303
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591087
[Journal Article] Immunohistochemical differenatiation of extra-ocular sebaceous carcinoma from other skin cancers2004
- Author(s)
  Ansai, S., Mitsuhashi, Y., Kondo, S., Manabe, M.
- Journal Title
  
  J Dermatol 31
  
  Pages: 998-1008
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591087
[Journal Article] A crucial autocrine/paracrine loop linking keratin 14 aggregates to TNFa-mediated cytotoxicity in epidermolysis bullosa simplex.2004
- Author(s)
  Yoneda, K., Furukawa, T., Zheng, Y-J., Momoi, T., Izawa, I., Inagaki, M., Manabe, M., Inagaki, N.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 7296-7303
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591087
[Journal Article] A Case of otomycosis by Aspergillus sclerotiorum2004
- Author(s)
  Harima, N., Inoue, T., Kubota, T., Okada, O., Ansai, S., Manabe, M., Ichinoe, M., Kasai, T.
- Journal Title
  
  J Dermatol 31
  
  Pages: 949-950
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591087
[Journal Article] Immunohistochemical differenatiation of extra-ocular sebaceous carcinoma from other skin cancers2004
- Author(s)
  Ansai, S., Mitsuhashi, Y., Kondo, S., Manabe,M.
- Journal Title
  
  J Dermatol 31
  
  Pages: 998-1008
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591087
[Journal Article] Reduced Expression and Aberrant Localization of p120catenin in Human Squamous Cell Carcinoma of the Skin2004
- Author(s)
  Ishizaki, Y., Omori, Y., Nishikawa, Y., Tokairin, T., Manabe, M., Enomoto.
- Journal Title
  
  J Dermatol Sci 34
  
  Pages: 99-108
- NAID
  10016183699
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591087
[Presentation] 師の背中を追って：皮膚バリア研究からの長い旅路2019
- Author(s)
  眞鍋　求
- Organizer
  日皮会東北六県合同地方会学術大会第386回例会（眞鍋求教授退官記念大会）
- Invited
- Data Source
  KAKENHI-PROJECT-17K10227
[Presentation] Topical 3-bromopyruvate is a novel targeted therapy for melanoma in preclinical model．2019
- Author(s)
  Yamada M，Kagaya M，Noguchi N，Osada SI，Manabe M
- Organizer
  日本研究皮膚科学会第44回年次学術大会
- Data Source
  KAKENHI-PROJECT-17K10227
[Presentation] 皮膚バリア研究の自分史：師の背中を追って2019
- Author(s)
  眞鍋　求
- Organizer
  第34回角化症研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17K10227
[Presentation] Sox13 is a novel marker for hair follicle development and differentiation2019
- Author(s)
  Noto M，Noguchi N，Manabe M，Osada SI
- Organizer
  49th Annunal European Society for Dermatological Research Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10227
[Presentation] Differential Regulation of wound healing by atypical protein kinase C isoforms．2017
- Author(s)
  Natsuko Noguchi，Shin-Ichi Osada，Tomonori Hirose，Tomoko Suzuki，Masami Kagaya，Kazuhiro Chida，Shigeo Ohno and Motomu Manabe
- Organizer
  第31回表皮細胞研究会
- Data Source
  KAKENHI-PROJECT-17K10227
[Presentation] Atypical protein kinase C isoform，aPKCλ，regulates directional cell migration during wound healing2017
- Author(s)
  Shin-Ichi Osada，Natsuko Noguchi，Tomonori Hirose，Tomoko Suzuki，Masami Kagaya，Kazuhiro Chida，Shigeo Ohno and Motomu Manabe
- Organizer
  日本研究皮膚科学会第42回年次学術大会・総会
- Data Source
  KAKENHI-PROJECT-17K10227
[Presentation] Differential rules of atypical protein kinase C isoforms in wound healing2017
- Author(s)
  Shin-Ichi Osada，Natsuko Noguchi，Tomonori Hirose，Tomoko Suzuki，Masami Kagaya，Kazuhiro Chida，Shigeo Ohno and Motomu Manabe
- Organizer
  47th Annual European Society for Dermatological Research
- Data Source
  KAKENHI-PROJECT-17K10227
[Presentation] A cell polarity protein，aPKCλ，regulates hair follicle regeneration after wounding．2017
- Author(s)
  Shin-Ichi Osada，Natsuko Noguchi，Tomonori Hirose，Tomoko Suzuki，Masami Kagaya，Kazuhiro Chida，Shigeo Ohno and Motomu Manabe
- Organizer
  10th World Congress for Hair Research
- Data Source
  KAKENHI-PROJECT-17K10227
[Presentation] The loss of p110 isoforms of PI3K led to ecreased incidence of epithelial neoplasma in PTEN-null mouse2008
- Author(s)
  Yamakawa, T. Nari.ta, T., Sasaki, T., Suzuki, A., Manabe. M.
- Organizer
  The 31st annual meeting of Northeast Japan Division of JDA
- Place of Presentation
  Sendai
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591231
[Presentation] PI3Kサブユニットの選択的遮断はマウス皮膚腫瘍の自然発症を抑制する。2008
- Author(s)
  山川岳洋・成田多恵・佐々木雄彦・鈴木聡・真鍋求
- Organizer
  日本皮膚科学会東北六県合同地方会学術大会第341回例会
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591231
[Presentation] Recovery of functional phenotypes in PTEN-null mouse by the loss of p 110 isoforms of P13K2007
- Author(s)
  Narita, T., Yamakawa, T., Sasaki, T., Manabe, M., Suzuki, A.
- Organizer
  The 21th annual meeting of keratinocyte biology society
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591231
[Presentation] PI3K欠損による表皮細胞特異的PTEN欠損マウスの表現形の回復と発癌抑制2007
- Author(s)
  成田多恵・山川岳洋・佐々木雄彦・真鍋求・鈴木聡
- Organizer
  第21回表皮細胞研究会
- Place of Presentation
  京都
- Year and Date
  2007-12-01
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591231

1. YAGUCHI Hitoshi (60191095)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. INOUE Tae (10301061)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. YONEDA Kozo (60260626)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 河村七美 (70323152)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. DEMITSU Toshio (20237027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SUGIYAMA Toshihiro (00127242)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TERADA Kunihiko (60197796)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KATO Yukio (10112062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SUZUKI Akira (10311565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HAMADA Kouichi (00343070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TSUDA Masaaki (30333925)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. Hasunuma Naoko (10282170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Horie Yasuo (30282164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 高森建二 (40053144)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 内藤勝一 (10138307)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 池田志学 (40193198)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. SUZUKI Tomoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KAGAYA Masami

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 能登舞

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MANABE MOTOMU 眞鍋 求

MANABE Motomu 真鍋 求

真鍋 求

Research Projects

Research Products

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Molecular mechanism of skin cancer development by functional ambiguity of aPKC lamdaPrincipal Investigator

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Role of INPP4B in melanoma development: possible effects of 3-BP as promising anticancer drugPrincipal Investigator

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Pathogenetic machanism for pyoderma gangrenosusm by disruption of the production pathway of phosphatidylinositol (3,5) biphosphate

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Molecular basis of melanomagenesis based on the failure of pluripotency maintenance of melanocyte stem cellsPrincipal Investigator

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Establishment of remodeling technologies for protein misfolding in keratin disorders using an inducible transgenic mouse modelPrincipal Investigator

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Development of molecular target-based therapy of cutaneous squamous cell carcinoma by selective block of PI3K isoformsPrincipal Investigator

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Roles for stat3 in carcinogenesis mouse model of Cowden diseasePrincipal Investigator

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Study of pathophysiology of keratin disease

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Construction of keratin disease keratinocyte model

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Development of the artificial organs from human stem cells.

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Biological roles of peptidylarginine deiminase in the pathogenic mechanisms of keratin deseases : molecular biological approachPrincipal Investigator

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Effects of Mutant Keratin Genes in Transfected Epidermal Cells : Establishment of Cell Models for GenodermatosesPrincipal Investigator

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Suppression of gene expression of steroid sulfatase by antisense RNA : Establishment of cellular model for X-linked ichthyosisPrincipal Investigator

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