HIRONO Shuichi 広野修一

… Alternative Names

広野修一ヒロノシユウイチ

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Researcher Number	30146328
Other IDs
External Links
Affiliation (Current)	2025: 北里大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2006 – 2019: 北里大学, 薬学部, 教授 1998 – 2004: 北里大学, 薬学部, 教授 1995 – 1996: 北里大学, 薬学部, 教授 1991 – 1993: 北里大学, 薬学部, 助教授 1991: 北里大学, 薬学部・, 助教授 1988 – 1989: School of Pharmaceutical Sciences, Kitasato University, 薬学部, 講師 1986 – 1987: 北里大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Physical pharmacy / Physical pharmacy / Drug development chemistry Except Principal Investigator Drug development chemistry / Physical pharmacy / Physical pharmacy / Pharmacology in pharmacy / 医薬分子機能学 / Biological pharmacy / Clinical oncology
Keywords	Principal Investigator NMR / TRNOE / SUPERPOSE / Molecular Dynamics / 結合配座 / 分子動力学法 / Ligand-Based Drug Design / Site II / Site I / 分子重ね合わせ法 … More / サイトII / サイトI / ヒト血清アルブミン / CAMDAS / Binding Conformation / Human Serum Albumin / ドラッグデザイン / 分子動力学計算 / カルモデュリン / バーチャルスクリーニング / 3D-Pharmacophore / フラグメントマッピング / イン・シリコ / FBDD / SBDD / フラグメントマッピング法 / in silico 創薬手法 / Pharmacokinetics / 3D-pharmacophore / Transporter / 3D-QSAR / in silico screening / 薬物動態 / 三次元ファーマコフォア / トランスポータ / 三次元定量的構造活性相関 / ligand docking / homology modeling / HERG / OT prolongation / binding conformation / molecular superpose / conformational search / QT延長作用 / 分子重ね合わせ / 配座解析 / リガンドドッキング / ホモロジーモデリング / QT延長 / HERGチャネル / Docking / 分子動力額計算 / ドッキング / Protein Binding / HAS / タンパク結合 / 分子動力学計算法 / Conformation Analysis / 血清アルブミン / 立体配座解析 / 抗ガン剤開発 / 蛋白-蛋白相互作用 / イン・シリコ創薬 / 医薬分子設計 / タンパク質間相互作用 / 抗癌剤 / 蛋白質-蛋白質相互作用 / イン・シリコ分子設計 / 抗ガン剤 / 複合体 / 阻害剤 / W-7 / TFP / 3次元構造解析 / 溶液構造 / 生体高分子 / 計算機実験 / 相互作用エネルギー解析 / カルモデュリン-メリチン複合体 / コンピュータグラフィックス / コンピュータシミュレーション / 標的蛋白質調節機構 / 標的蛋白質認識機構 … More Except Principal Investigator フォールディング / シャペロン / イミノ糖 / グリコシダーゼ / リソソーム病 / イオンチャネル / ドラッグデザイン / 結合自由エネルギー / ドッキング計算 / 阻害剤 / 適応最小二乗法 / 定量的構造活性相関 / pharmacophore / organic anion / transporter / OATP / OAT / MRP / 血液脳関門 / 有機アニオン / トランスポーター / 構造毒性相関 / 急性毒性 / パターン認識 / テイ-サックス病 / テイーサックス病 / ストア作動性カルシウム流入 / 薬理学 / 分子動力学 / キチナーゼ / 魚毒性 / 軟骨細胞 / 脳血管内皮細胞 / CRACチャネル / ClC-7チャネル / Kir2.1チャネル / 細胞膜電位 / カルシウムシグナリング / 生物物理 / イメージング / シグナル伝達 / 生体分子 / 生理学 / パッチクランプ / 蛍光イメージング / 創薬 / カルシウムシグナル / 薬学 / pattern recognition / quantitative structure-activity relationship / structure-toxicity relationship / aquatic toxicity / human acute toxicity / toxicity prediction / ヒト経口急性毒性 / ヒト経口毒性 / 毒性予測 / substrate specificity / efflux transport / blood-brain barrier / 基質選択性 / ファーマコフォア / 排出輸送 / CAMDAS / blood-CSF barrier / blood-brain barrer / MRP1 / OAT3 / Oatp14 / Oat3 / 排出ポンプ / 3次元構造活性相関 / 血液脳脊髄液関門 / Biodegradability / Mutagenicity / Carcinogenicity / Human acute toxicity / Aquatic toxicity / Toxicity prediction / Quantitative structure-toxicity relationship / 有機化学物質 / 安全性 / ファジィ集合 / ファジィ理論 / 生分解性 / 変異原性 / 発がん性 / 疎水性 / 有害性予測 / Amphiphthic / planar bilayer / model peptide / ion channel / 抗菌活性 / 二次構造 / 平面膜法 / Kチャネル / 合成ペプチド / 両親媒性 / 脂質平面膜 / モデルペプチド / 分子動力学シミュレーション / 結合自由エネルギー計算 / 分子ドッキング計算 / SBDD / インスリン / 糖尿病 / SHIP2 / 分子設計 / 分子イメージング / ストア依存性カルシウム流入 / イオンチャネル標的創薬 / カルシウムチャネル / カリウムチャネル / 薬理 / ストア作動性カルシウムチャネル / 発現調節 / 細胞内カルシウム動態 / 正帰還カルシウム制御機構 / カルシウム活性化カリウムチャネル / 非興奮性細胞 / 情報システム / 分子薬理学 / 分子標的薬 / がん治療 / 抗真菌薬 / 喘息治療薬 / 結合配座 / リガンドドッキング / 構造活性 / 計算機 / がん細胞パネル / 3次元ファーマコフォア / 計算機化学 / バソプレシン阻害薬 / ファジィ / パタ-ン認識 / 活性等級予測 Less

Analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay-Sachs disease
- Principal Investigator
  
  KATO Atsushi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Toyama
Development of in silico fragment-based drug design method for rational drug discoveryPrincipal Investigator
- Principal Investigator
  
  Hirono Shuichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University
Design and synthesis of iminosugar-based pharmacological chaperone as a structure stabilizing agent for mutation enzyme
- Principal Investigator
  
  Kato Atsushi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Toyama
Molecular pharmacological analyses of calcium-activated ion channels as novel drug targets
- Principal Investigator
  
  Imaizumi Yuji
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Nagoya City University
In silico drug design of SHIP2 inhibitor as a novel therapeutic agent for diabetes.
- Principal Investigator
  
  GOUDA Hiroaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Showa University
  Kitasato University
Positive feedback mechanism for the regulation of intracellular Ca2+ concentration and related ion channels as novel drug targets
- Principal Investigator
  
  IMAIZUMI Yuji
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagoya City University
Design, synthesis, and biological evaluation of iminosugars as pharmacological chaperone for Gaucher disease
- Principal Investigator
  
  KATO Atsushi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Toyama
Discovery of innovative molecular targeted drugs based on Cancer Cell Informatics
- Principal Investigator
  
  YAMORI Takao
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Clinical oncology
- Research Institution
  Japanese Foundation For Cancer Research
Optimization of chitinase inhibitor with macrolide scaffold based on in silico drug discovery techniques
- Principal Investigator
  
  GOUDA Hiroaki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University
In silico drug design study targeting CRK-C3G interaction for future development of anticarcinogenic agentPrincipal Investigator
- Principal Investigator
  
  HIRONO Shuichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kitasato University
Computer-aided rational molecular design of novel chitinase inhibitor
- Principal Investigator
  
  GOUDA Hiroaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University
3D-pharmacophore analyses of transporter ligands for drug discovery studies in consideration of pharmacokineticsPrincipal Investigator
- Principal Investigator
  
  HIRONO Shuichi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University
がん細胞パネルと計算機による3次元ファーマコフォアの抽出
- Principal Investigator
  
  YAMORI Takao
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Japanese Foundation For Cancer Research
New strategy for the drug development of CNS acting drugs by regulating drug transport across the blood-brain barrier
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Three-dimensional structure-activity relationships of drugs induced cardiovascular side effects (prolongation in the QT interval)Principal Investigator
- Principal Investigator
  
  HIRONO Shuichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  School of Pharmaceutical sciences, Kitasato University
Drug design based on the substrate specificity of the efflux transporters expressed in the blood-brain barrier
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo
Determination of binding conformations of drugs to HAS and modeling of drug-HAS complexPrincipal Investigator
- Principal Investigator
  
  HIRONO Shuichi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University
分子動力学シミュレーションによるカルモデュリン-阻害剤複合体の溶液構造解析Principal Investigator
- Principal Investigator
  
  広野修一
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kitasato University
Analysis of binding conformations of drugs to human serum albumin (site I and site II) by NMR measurements and computational calculationsPrincipal Investigator
- Principal Investigator
  
  HIRONO Shuichi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University
Determination of Binding Conformation of Drugs to Human Serum Albumin by Molecular Dynamics Calculations and Transferred Nuclear Overhauser Effect MeasurementsPrincipal Investigator
- Principal Investigator
  
  HIRONO Shuichi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University
分子動力学シミュレーシヨンによる生体高分子の新しい立体配座解析法の研究Principal Investigator
- Principal Investigator
  
  広野修一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University
分子動力学シミュレーションによるカルモデュリンの標的蛋白質認識・調節機構の研究Principal Investigator
- Principal Investigator
  
  広野修一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University
Synthetic Model Peptides for the Study of Structure-Activity Relationship of Ion Channels Using Planar Lipid Bilayer Technique
- Principal Investigator
  
  ANZAI Kazunori
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyushu University
Prediction of Toxicity of Organic Chemicals Using Fuzzy Adaptive Least-Squares
- Principal Investigator
  
  MORIGUCHI Ikuo
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University
ファジィ適応最小二乗法の開発とその定量的構造活性相関解析への応用
- Principal Investigator
  
  MORIGUCHI Ikuo
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University
Prediction of Human Acute Toxicity and Aquatic Toxicity from Chemical Structure by Pattern Recognition
- Principal Investigator
  
  MORIGUCHI Ikuo
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University

[Book] 次世代ゲノム創薬2003
- Author(s)
  広野修一
- Total Pages
  21
- Publisher
  中山書店
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590048
[Journal Article] Characterising the selectivity of ER α-glucosidase inhibitors.2019
- Author(s)
  O’Keefe, S., Roebuck, Q., Nakagome, I., Hirono, S., Kato, A., Nash, R. J., High, S.
- Journal Title
  
  Glycobiology
  
  Volume: 29 (7) Issue: 7 Pages: 530-542
- DOI
  10.1093/glycob/cwz029
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08362
[Journal Article] Exploration of DPP-IV inhibitors with a novel scaffold by multistep in silico screening2018
- Author(s)
  Taro Uchida, Masaki Wakasugi, Takahiro Kitamura, Tomomi Yamamoto, Mitsutoshi Asakura, Ryoichi Fujiwara, Tomoo Itoh, Hideaki Fujii, Shuichi Hirono
- Journal Title
  
  Journal of Molecular Graphics and Modelling
  
  Volume: 79 Pages: 254-263
- DOI
  10.1016/j.jmgm.2017.12.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07899
[Journal Article] Design of a new α-1-C-alkyl-DAB derivative acting as a pharmacological chaperone for β-glucocerebrosidase using ligand docking and molecular dynamics simulation.2018
- Author(s)
  Nakagom, I., Kato, A., Yamaotsu, N., Yoshida, T., Ozawa, S., Adachi, I., Hirono, S.
- Journal Title
  
  Molecules
  
  Volume: 23 Issue: 10 Pages: 2683-2693
- DOI
  10.3390/molecules23102683
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08362
[Journal Article] In silico analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay?Sachs disease2017
- Author(s)
  Kato, A., Nakagome, I., Nakagawa, S., Kinami, K., Adachi, I., Jenkinson, S. F., Desire, J., Bleriot, Y., Nash, R. J., Fleet, G. W. J., Hirono, S.
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 15 Issue: 44 Pages: 9297-9304
- DOI
  10.1039/c7ob02281f
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08362, KAKENHI-PROJECT-15K07899
[Journal Article] Multi-step virtual screening to develop selective DYRK1A inhibitors2017
- Author(s)
  Tomoko Koyama, Noriyuki Yamaotsu, Izumi Nakagome, Shin-ichiro Ozawa, Tomoki Yoshida, Daichi Hayakawa, Shuichi Hirono
- Journal Title
  
  Journal of Molecular Graphics and Modelling
  
  Volume: 72 Pages: 229-239
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07899
[Journal Article] Docking study and biological evaluation of pyrrolidine-based iminosugars as pharmacological chaperones for Gaucher disease2016
- Author(s)
  Atsushi Kato, Izumi Nakagome, Kasumi Sato, Arisa Yamamoto, Isao Adachi, Robert J. Nash, George W. J. Fleet, Yoshihiro Natori, Yasuka Wasuka, Tatsushi Imahori, Yuichi Yoshimura, Hiroki Takahata and Shuichi Hirono
- Journal Title
  
  Org. Bio. Chem.
  
  Volume: 14 Issue: 3 Pages: 1039-1048
- DOI
  10.1039/c5ob02223a
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K05437, KAKENHI-PROJECT-26460143, KAKENHI-PROJECT-25860088
[Journal Article] Three-dimensional quantitative structure-activity relationship analysis for human pregnane X Receptor for the prediction of CYP3A4 induction in human hepatocytes: structure-based comparative molecular field analysis.2015
- Author(s)
  Koichi Handa, Izumi Nakagome, Noriyuki Yamaotsu, Hiroaki Gouda, Shuichi Hirono.
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 104 Issue: 1 Pages: 223-232
- DOI
  10.1002/jps.24235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590058
[Journal Article] Design and synthesis of labystegines, hybrid iminosugars from LAB and calystegine, as inhibitors of intestinal α-glucosidases: binding conformation and interaction for ntSI.2015
- Author(s)
  Kato, A., Zhang, Z.-L., Wang, H.-Y., Jia, Y.-M., Yu, C.-Y., Kinami, K., Hirokami, Y., Tsuji, Y., Adachi, I., Nash, R. J., Fleet, G. W. J., Koseki, J., Nakagome, I., Hirono, S.
- Journal Title
  
  J. Org. Chem.
  
  Volume: 80(9) Issue: 9 Pages: 4501-4515
- DOI
  10.1021/acs.joc.5b00342
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460143
[Journal Article] Docking and SAR studies of calystegines : binding orientation and influence on pharmacological chaperone effects for Gaucher’s disease.2014
- Author(s)
  Kato, A., Nakagome, I., Nakagawa, S., Koike, Y., Nash, R. J., Adachi, I., Hirono, S.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 22 (8) Issue: 8 Pages: 2435-2441
- DOI
  10.1016/j.bmc.2014.02.057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590127
[Journal Article] Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism.2014
- Author(s)
  Hiroshi Nagase, Ryo Nakajima, Naoshi Yamamoto, Shigeto Hirayama, Takashi Iwai, Toru Nemoto, Hiroaki Gouda, Shuichi Hirono, Hideaki Fujii.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 24 Issue: 13 Pages: 2851-2854
- DOI
  10.1016/j.bmcl.2014.04.098
- NAID
  120007136687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590058
[Journal Article] In silico and pharmacological screenings identify novel serine racemase inhibitors.2014
- Author(s)
  Hisashi Mori, Ryogo Wada, Jie Li, Tetsuya Ishimoto, Mineyuki Mizuguchi, Takayuki Obita, Hiroaki Gouda, Shuichi Hirono, Naoki Toyooka.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 24 Issue: 16 Pages: 3732-3735
- DOI
  10.1016/j.bmcl.2014.07.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590058, KAKENHI-PROJECT-25293059, KAKENHI-PROJECT-26840018
[Journal Article] <i>In Silico</i> Study on the Inhibitory Interaction of Drugs with Wild-type CYP2D6.1 and the Natural Variant CYP2D6.172014
- Author(s)
  Koichi Handa, Izumi Nakagome, Noriyuki Yamaotsu, Hiroaki Gouda, Shuichi Hirono
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 29 Issue: 1 Pages: 52-60
- DOI
  10.2133/dmpk.DMPK-13-RG-044
- NAID
  130004463344
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590058
[Journal Article] Conformational folding of mycobacterial methoxy- and ketomycolic acids facilitated by α-methyl trans-cyclopropane groups rather than cis-cyclopropane units2013
- Author(s)
  Masumi Villeneuve,　Mizuo Kawai,　Kieko Horiuchi,　Motoko Watanabe,　Yutaka Aoyagi,　Yukio Hitotsuyanagi,　Koichi Takeya,　Hiroaki Gouda,　Shuichi Hirono,　David E. Minnikin
- Journal Title
  
  Microbiology
  
  Volume: 159 Issue: Pt_11 Pages: 2405-2415
- DOI
  10.1099/mic.0.068866-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590058
[Journal Article] Human acidic mammalian chitinase as a novel target for anti-asthma drug design using in silico screening2013
- Author(s)
  Masaki Wakasugi, Hiroaki Gouda, Tomoyasu Hirose, Akihiro Sugawara, Tsuyoshi Yamamoto, Kazuro Shiomi, Toshiaki Sunazuka, Satoshi Omura, Shuichi Hirono
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 21 Issue: 11 Pages: 3214-3220
- DOI
  10.1016/j.bmc.2013.03.047
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23105012, KAKENHI-PUBLICLY-24102527, KAKENHI-PROJECT-24590058, KAKENHI-PROJECT-24790022, KAKENHI-PROJECT-25460020
[Journal Article] Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor2013
- Author(s)
  Hirose T, Maita N, Taniguchi H, Sharpless KB, Omura S, Sunazuka T
- Journal Title
  
  Proc.Natl.Acad.Sci. USA.
  
  Volume: 110 Issue: 40 Pages: 15892-15897
- DOI
  10.1073/pnas.1315049110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370042, KAKENHI-PLANNED-23105012, KAKENHI-PROJECT-23570139, KAKENHI-PUBLICLY-24102527, KAKENHI-PROJECT-24580104, KAKENHI-PROJECT-24590058, KAKENHI-PROJECT-24790022, KAKENHI-PROJECT-25460020
[Journal Article] Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2).2013
- Author(s)
  Ichihara Y, Fujimura R, Tsuneki H, Wada T, Okamoto K, Gouda H, Hirono S, Sugimoto K, Matsuya Y, Sasaoka T, Toyooka N.
- Journal Title
  
  Eur J Med Chem.
  
  Volume: 62 Pages: 649-660
- DOI
  10.1016/j.ejmech.2013.01.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659774, KAKENHI-PROJECT-24390056, KAKENHI-PROJECT-24590058
[Journal Article] α-1-C-Butyl-LAB as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia.2012
- Author(s)
  Kato, A., Hayashi, E., Miyauchi, S., Adachi, I., Imahori, T., Natori, Y., Yoshimura, Y., Nash, R. J., Shimaoka, H., Nakagome, I., Koseki, J., Hirono, S., Takahata, H.
- Journal Title
  
  J. Med. Chem.
  
  Volume: 55 (23) Issue: 23 Pages: 10347-10362
- DOI
  10.1021/jm301304e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590059, KAKENHI-PROJECT-22590104, KAKENHI-PROJECT-23590012, KAKENHI-PROJECT-23590127, KAKENHI-PROJECT-23790138
[Journal Article] Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2 : Propellane derivatives with an amide side chain2012
- Author(s)
  Hiroshi Nagase, Junko Akiyama, Ryo Nakajima, Shigeto Hirayama, Toru Nemoto, Hiroaki Gouda, Shuichi Hirono, Hideaki Fujii
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 22(8) Issue: 8 Pages: 2775-2779
- DOI
  10.1016/j.bmcl.2012.02.082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590046, KAKENHI-PROJECT-21590122, KAKENHI-PROJECT-24590058
[Journal Article] Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 3, novel propellane derivatives with pentacyclic skeletons.2012
- Author(s)
  4. Hideaki Fujii, Ryo Nakajima, Junko Akiyama, Naoshi Yamamoto, Shigeto Hirayama, Toru Nemoto, Hiroaki Gouda, Shuichi Hirono, Hiroshi Nagase.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 22 Issue: 24 Pages: 7697-7701
- DOI
  10.1016/j.bmcl.2012.09.102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590058
[Journal Article] Three-Dimensional Solution Structure of Bottromycin A2: A Potent Antibiotic Active against Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci2012
- Author(s)
  Hiroaki Gouda, Yutaka Kobayashi, Takeshi Yamada, Tetsuya Ideguchi, Akihiro Sugawara, Tomoyasu Hirose, Satoshi Omura, Toshiaki Sunazuka, Shuichi Hirono
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 60 Issue: 2 Pages: 169-171
- DOI
  10.1248/cpb.60.169
- NAID
  130001852392
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590046, KAKENHI-PROJECT-21590122, KAKENHI-PROJECT-22790017, KAKENHI-PROJECT-23890202
[Journal Article] Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: Synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies2012
- Author(s)
  Fujii, H.; Imaide, S.; Hirayama, S.; Nemoto, T.; Gouda, H.; Hirono, S.; Nagase, H.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 22 Issue: 24 Pages: 7711-7714
- DOI
  10.1016/j.bmcl.2012.09.101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590133, KAKENHI-PROJECT-24590058
[Journal Article] AMF-26, a Novel Inhibitor of the Golgi System, Targeting ADP-ribosylation Factor 1 (Arf1) with Potential for Cancer Therapy2012
- Author(s)
  Ohashi Y, Iijima H, Yamaotsu N, Yamazaki K, Sato S, Okamura M, Sugimoto K, Dan S, Hirono S, Yamori T
- Journal Title
  
  J Biol Chem
  
  Volume: 287(6) Issue: 6 Pages: 3885-3897
- DOI
  10.1074/jbc.m111.316125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240092, KAKENHI-PROJECT-22590042, KAKENHI-PROJECT-22700929, KAKENHI-PROJECT-221S0001
[Journal Article] Novel 12-membered non-antibiotic macrolides from erythromycin A ; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents2011
- Author(s)
  Akihiro Sugawara, Akito Sueki, Tomoyasu Hirose, Kenichiro Nagai, Hiroaki Gouda, Shuichi Hirono, Hideaki Shima, Kiyoko S. Akagawa, Satoshi Omura, Toshiaki Sunazuka
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 21(11) Issue: 11 Pages: 3373-3376
- DOI
  10.1016/j.bmcl.2011.04.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590046, KAKENHI-PROJECT-21590122, KAKENHI-PROJECT-22790017, KAKENHI-PROJECT-22890175
[Journal Article] Identification of the three-dimensional pharmacophore of kappa-opioid receptor agonists.2010
- Author(s)
  Noriyuki Yamaotsu, Hideaki Fujii, Hiroshi Nagase, Shuichi Hirono
- Journal Title
  
  Bioorg.Med.Chem.
  
  Volume: 18 Pages: 4446-4452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590122
[Journal Article] NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin2010
- Author(s)
  Gouda H, Sunazuka T, Hirose T, Iguchi K, Yamaotsu N, Sugawara A, Noguchi Y, Saito Y, Yamamoto T, Watanabe T, Shiomi K, Omura S, Hirono S
- Journal Title
  
  Bioorg.Med.Chem.
  
  Volume: 18 Pages: 5835-5844
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590122
[Journal Article] NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin2010
- Author(s)
  Hiroaki Gouda, Toshiaki Sunazuka, Tomoyasu Hirose, Kanami Iguchi, Noriyuki Yamaotsu, Akihiro Sugawara, Yoshihiko Noguchi, Yoshifumi Saito, Tsuyoshi Yamamoto, Takeshi Watanabe, Kazuro Shiomi, Satoshi Omura, Shuichi Hirono
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 18(16) Issue: 16 Pages: 5835-5844
- DOI
  10.1016/j.bmc.2010.06.093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590046, KAKENHI-PROJECT-21590122, KAKENHI-PROJECT-22590042, KAKENHI-PROJECT-22790017, KAKENHI-PROJECT-22890175
[Journal Article] Identification of the threedimensional pharmacophore ofκ-opioid receptor agonists2010
- Author(s)
  Noriyuki Yamaotsu, Hideaki Fujii, Hiroshi Nagase, Shuichi Hirono
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 18 Pages: 4446-4452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590122
[Journal Article] Differential conformational behaviors ofα-mycolic acids in Langmuir monolayers and computer simulations2010
- Author(s)
  Masumi Villeneuve, Mizuo Kawai, Motoko Watanabe, Yutaka Aoyagi, Yukio Hitotsuyanagi, Koichi Takeya, Hiroaki Gouda, Shuichi Hirono, David E. Minnikin, Hiroo Nakahara
- Journal Title
  
  Chem. Phys. Lipids
  
  Volume: 163(6) Issue: 6 Pages: 569-579
- DOI
  10.1016/j.chemphyslip.2010.04.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590046, KAKENHI-PROJECT-21590122
[Journal Article] Investigation of Beckett-Casy model 3 : Synthesis of novel naltrexone derivatives with contracted and expanded D-rings and their pharmacology2010
- Author(s)
  Hiroshi Nagase, Satomi Imaide, Miyuki Tomatsu, Shigeto Hirayama, Toru Nemoto, Noriko Sato, Mayumi Nakajima, Kaoru Nakao, Hidenori Mochizuki, Hiroaki Gouda, Shuichi Hirono, Hideaki Fujii
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 20(12) Issue: 12 Pages: 3801-3804
- DOI
  10.1016/j.bmcl.2010.04.044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590046, KAKENHI-PROJECT-21590122
[Journal Article] Thiolactomycin inhibits D-aspartate oxidase : a novel approach to probing the active site environment2010
- Author(s)
  Katane M, Saitoh Y, Hanai T, Sekine M, Furuchi T, Koyama N, Nakagome I, Tomoda H, Hirono S, Homma H
- Journal Title
  
  Biochimie.
  
  Volume: 92 Pages: 1371-1378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590122
[Journal Article] Drug design and synthesis of a novelκopioid receptor agonist with an oxabicyclo[2.2.2] octane skeleton and its pharmacology2010
- Author(s)
  Hiroshi Nagase, Akio Watanabe, Toru Nemoto, Noriyuki Yamaotsu, Kohei Hayashida, Mayumi Nakajima, Ko Hasebe, Kaoru Nakao, Hidenori Mochizuki, Shuichi Hirono, Hideaki Fujii
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 20 Pages: 121-124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590122
[Journal Article] Design and synthesis of novel delta opioid receptor agonists and their pharmacologies2009
- Author(s)
  Hiroshi Nagase, Yumiko Osa, Toru Nemoto, Hideaki Fujii, Masayuki Imai, Takeshi Nakamura, Toshiyuki Kanemasa, Akira Kato, Hiroaki Gouda, Shuichi Hirono
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 19(10) Issue: 10 Pages: 2792-2795
- DOI
  10.1016/j.bmcl.2009.03.099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590046, KAKENHI-PROJECT-21590122
[Journal Article] Computer-aided rational molecular design of argifin-derivatives with increased inhibitory activity against chitinase B from Serratia marcescens2009
- Author(s)
  Gouda H, Sunazuka T, Iguchi K, Sugawara A, Hirose T, Noguchi Y, Saito Y, Yanai Y, Yamamoto T, Watanabe T, Shiomi K, Omura S, Hirono S
- Journal Title
  
  Bioorg. Med. Chem. Lett. 19(10)
  
  Pages: 2630-2633
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590043
[Journal Article] Design and synthesis of novel delta opioid receptor agonists and their pharmacologies2009
- Author(s)
  Nagase H, Osa Y, Nemoto T, Fujii H, Imai M, Nakamura T, Kanemasa T, Kato A, Gouda H, Hirono S
- Journal Title
  
  Bioorg. Med. Chem. Lett. 19(10)
  
  Pages: 2792-2795
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590043
[Journal Article] In silico創薬技術に基づくSBDDの実際.2009
- Author(s)
  広野修一、合田浩明
- Journal Title
  
  蛋白質核酸酵素 54
  
  Pages: 1590-1597
- Data Source
  KAKENHI-PROJECT-21590046
[Journal Article] In silico創薬技術に基づくSBDDの実際2009
- Author(s)
  広野修一、合田浩明
- Journal Title
  
  蛋白質核酸酵素 54
  
  Pages: 1590-1597
- Data Source
  KAKENHI-PROJECT-21590122
[Journal Article] Lys17 in the 'lasso' peptide lariatin A is responsible for anti-mycobacterial activity2009
- Author(s)
  Iwatsuki M, Koizumi Y, Gouda H, Hirono S, Tomoda H, Omura S.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 19 Issue: 10 Pages: 2888-2890
- DOI
  10.1016/j.bmcl.2009.03.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200037, KAKENHI-PROJECT-21590046, KAKENHI-PROJECT-21590122
[Journal Article] Structure Determination and Total Synthesis of Bottromycin A2 : A Potent Antibiotic against MRSA and VRE2009
- Author(s)
  Shimamura H, Gouda H, Nagai K, Hirose T, Ichioka M, Furuya Y, Kobayashi Y, Hirono S, Sunazuka T, Omura S
- Journal Title
  
  Angew. Chem. -Int. Edit. 48
  
  Pages: 914-917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590043
[Journal Article] Structure-Based CoMFA As a Predictive Model-CYP2C9 Inhibitors As a Test Case2009
- Author(s)
  Yasuo K, Yamaotsu N, Gouda H, Tsujishita H, Hirono S
- Journal Title
  
  J. Chem. Inf. Model 49(4)
  
  Pages: 853-864
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590043
[Journal Article] Computer-aided rational molecular design of argifin-derivatives with increased inhibitory activity against chitinase B from Serratia marcescens2009
- Author(s)
  Hiroaki Gouda, Toshiaki Sunazuka, Kanami Iguchi, Akihiro Sugawara, Tomoyasu Hirose, Yoshihiko Noguchi, Yoshifumi Saito, Yuichi Yanai, Tsuyoshi Yamamoto, Takeshi Watanabe, Kazuro Shiomi, Satoshi. mura, Shuichi Hirono
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 19(10) Issue: 10 Pages: 2630-2633
- DOI
  10.1016/j.bmcl.2009.04.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590046, KAKENHI-PROJECT-21590122
[Journal Article] Molecular modeling of human acidic mammalian chitinase in complex with the natural-product cyclopentapeptide chitinase inhibitor argifin2009
- Author(s)
  Hiroaki Gouda, Shinichi Terashima, Kanami Iguchi, Akihiro Sugawara, Yoshifumi Saito, Tsuyoshi Yamamoto, Tomoyasu Hirose, Kazuro Shiomi, Toshiaki Sunazuka, Satoshi. mura, Shuichi Hirono
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 17(17) Issue: 17 Pages: 6270-6278
- DOI
  10.1016/j.bmc.2009.07.045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590046, KAKENHI-PROJECT-21590122
[Journal Article] Lys17 in the 'lasso' peptide lariatin A is responsible for anti-mycobacterial activity2009
- Author(s)
  Iwatsuki M, Koizumi Y, Gouda H, Hirono S, Tomoda H, Omura S
- Journal Title
  
  Bioorg. Med. Chem. Lett. 19(10)
  
  Pages: 2888-2890
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590043
[Journal Article] In silico multi-filter screening approaches for developing novel β -secretase inhibitors2008
- Author(s)
  Fujimoto T, Matsushita Y, Gouda H, Yamaotsu N, Hirono S
- Journal Title
  
  Bioorg. Med. Chem. Lett. 18(9)
  
  Pages: 2771-2775
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590043
[Journal Article] Computational Analysis of the Binding Affinities of the Natural-Product Cyclopentapeptides Argifin and Argadin to Chitinase B from Serratia marcescens2008
- Author(s)
  Gouda H, Yanai Y, Sugawara A, Sunazuka T, ?mura S, Hirono S.
- Journal Title
  
  Bioorg. Med. Chem. 16(7)
  
  Pages: 3565-3579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590043
[Journal Article] MM-PBSA法を用いたキチナーゼ阻害剤ArgadinおよびArgifinの結合自由エネルギー計2008
- Author(s)
  合田浩明, 柳井雄一, 広野修一
- Journal Title
  
  Pharma VISION NEWS No.11(March)
  
  Pages: 7-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590043
[Journal Article] イン・シリコ創薬技術に基づく合理的薬剤分子設計2008
- Author(s)
  広野修一
- Journal Title
  
  薬剤学 68
  
  Pages: 107-115
- NAID
  10025719980
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590037
[Journal Article] 第4章4 トランスポーターの3D-QSAR解析2007
- Author(s)
  広野修一
- Journal Title
  
  最新創薬学2007(杉山雄一編), 株式会社メディカルドゥ
  
  Pages: 303-303
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590037
[Journal Article] Conformational behavior of oxygenated mycobacterial mycolic acids from Mycobacterium bovis BCG2007
- Author(s)
  Villeneuve M, Kawai M, Watanabe M, Aoyagi Y, Hitotsuyanagi Y, Takeya K, Gouda H, Hirono S, Minnikin DE, Nakahara H
- Journal Title
  
  Biochim. Biophys. Acta. 1768(7)
  
  Pages: 1717-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590043
[Journal Article] Lariatins, Antimycobacterial Peptides Produced by Rhodococcus sp. K101-B0171, Have a Lasso Structure2006
- Author(s)
  Iwatsui M., Tomoda H., Uchida R., Gouda H., Hirono S., Omura S.
- Journal Title
  
  J. Am. Chem. Soc. 128(23)
  
  Pages: 7486-7491
- Data Source
  KAKENHI-PROJECT-18590037
[Journal Article] Three-dimensional solution structure of EM703 with potent promoting activity of monocyte-to-macrophage differentiation2006
- Author(s)
  Gouda H., Sunazuka T., Yoshida K., Sugawara A., Sakoh Y., Omura S., Hirono S.
- Journal Title
  
  Bioorganic ＆ Medicinal Chemistry Letters 16(9)
  
  Pages: 2496-2499
- Data Source
  KAKENHI-PROJECT-18590037
[Journal Article] A novel phosphatidylinositol-3-kinase inhibitor, ZATK474, with potent antitumor activity and low toxicity2006
- Author(s)
  Yaguchi S., Fukui Y., Koshimizu I., Yoshimi H., Matsuo T., Gouda H., Hirono S., Yamazaki K., Yamori T
- Journal Title
  
  J. the National Cancer Institute 98(8)
  
  Pages: 545-556
- Data Source
  KAKENHI-PROJECT-18590037
[Journal Article] Estimation of the three-dimensional pharmacophore of ligands for rat multidrug-resistance-associated protein 2 using ligand-based drug design techniques2005
- Author(s)
  Hirono S, Nakagome I, Imai R, Maeda K, Kusuhara H, Sugiyama Y
- Journal Title
  
  Pharmaceutical Research 22
  
  Pages: 260-269
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590048
[Journal Article] Estimation of the three-dimensional pharmacophore of ligands for rat multidrug-resistance-associated protein 2 using ligand-based drug design technique2005
- Author(s)
  Hirono S, Nakagome I, Imai R, Maeda K, Kusuhara H, Sugiyama Y
- Journal Title
  
  Pharmaceutical Research 22
  
  Pages: 260-269
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590048
[Journal Article] Studies of Binding Modes of (S)-Mephenytoin to Wild Types and Mutants of Cytochrome P450 2C19 and 2C9 using Homology Modeling and Computational Docking2004
- Author(s)
  Oda A, Yamaotsu N, Hirono S
- Journal Title
  
  Pharm.Res 21(12)
  
  Pages: 2270-2278
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590048
[Journal Article] Geometry-dependent atomic charge calculations using charge equilibration method with empirical two-center Coulombic terms.2003
- Author(s)
  Akifumi Oda, Shuichi Hirono
- Journal Title
  
  Journal of Molecular Structure:(THEOCHEM) 634
  
  Pages: 159-170
- Data Source
  KAKENHI-PROJECT-15659028
[Journal Article] Studies of Binding Modes of (S)-Mephenytoin to Wild Types and Mutants of Cytochrome P450 2C19 and 2C19 using Homology Modeling and Computational Docking2003
- Author(s)
  Oda A, Yamaotsu N, Hirono S
- Journal Title
  
  Pharm.Res 21(12)
  
  Pages: 2270-2278
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590048
[Journal Article] The introduction of atom types and calculations of new parameters for charge equilibrium method2003
- Author(s)
  Oda A, Hirono S
- Journal Title
  
  Journal of Computer Chemistry, Japan 2(1)
  
  Pages: 17-26
- NAID
  130000056713
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590048
[Journal Article] Geometry-dependent atomic charge calculations using charge equilibration method with empirical two-center Coulombic terms2003
- Author(s)
  Oda A, Hirono S
- Journal Title
  
  Journal of Molecular Structure : (THEOCHEM) 634
  
  Pages: 159-170
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590048
[Journal Article] Computer-aided modeling of pentachlorophenol 4-monooxygenase and site-directed mutagenesis of its active site.2003
- Author(s)
  Takashi Nakamura, Takayuki Motoyama, Takatsugu Hirokawa, Shuichi Hirono, Isamu Yamaguchi
- Journal Title
  
  Chem.Pharm.Bull. 51(11)
  
  Pages: 1293-1298
- Data Source
  KAKENHI-PROJECT-15659028
[Journal Article] The introduction of atom types and calculations of new parameters for charge equilibrium method.2003
- Author(s)
  Akifumi Oda, Shuichi Hirono
- Journal Title
  
  Journal of Computer Chemistry, Japan 2(1)
  
  Pages: 17-26
- NAID
  130000056713
- Data Source
  KAKENHI-PROJECT-15659028
[Presentation] Hex A高親和性リガンドのin silico解析とTay-Sachs病に対するファーマコロジカルシャペロン効果の検証2019
- Author(s)
  加藤　敦、中込泉、中川進平、島立優奈、足立伊佐雄、広野修一
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K08362
[Presentation] MDシミュレーションによるβ-glucocerebrosidase-ケミカルシャペロンα-1-C-tridecyl-DAB複合体の構造安定性解析2019
- Author(s)
  中込泉、加藤　敦、山乙教之、広野修一
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K08362
[Presentation] Hex A高親和性リガンドの創製とTay-Sachs病に対するファーマコロジカルシャペロン効果の検証2018
- Author(s)
  加藤　敦、中込　泉、久保萌美、今枝秀貴、足立伊佐雄、広野修一
- Organizer
  第37回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-17K08362
[Presentation] アミノ酸残基マッピング法を用いたPPI 界面における相互作用スポット予測手法の開発2017
- Author(s)
  市村博信，山乙教之，広野修一
- Organizer
  第45 回構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07899
[Presentation] イン・シリコフラグメントマッピング法を用いた新規PAD4阻害剤の探索2017
- Author(s)
  片村百々奈、中込泉、山乙教之、広野修一
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K07899
[Presentation] In silico フラグメントマッピング法を用いたリガンド結合様式予測法の開発2017
- Author(s)
  杉山耀司，山乙教之，吉田智喜，広野修一
- Organizer
  第45 回構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07899
[Presentation] 1.アミノ酸残基－サブサイトデータベースを用いた新規PPI界面予測手法の開発2017
- Author(s)
  市村博信、山乙教之、広野修一
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K07899
[Presentation] フラグメントマッピング法によるUSP7-HDM2 タンパク質間相互作用(PPI)阻害剤の探2017
- Author(s)
  三沢　憲佑, 小澤　新一郎, 吉田　智喜, 中込　泉, 山乙　教之, 広野　修一
- Organizer
  第３5 回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-15K07899
[Presentation] イン・シリコフラグメントマッピングに基づく新規Rac1 PPI 阻害剤の同定2017
- Author(s)
  北村祐万，小澤新一郎，広野修一
- Organizer
  第45 回構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07899
[Presentation] SBDD のためのin silico フラグメント・マッピング法の開発2017
- Author(s)
  山乙教之，広野修一
- Organizer
  第45 回構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07899
[Presentation] 筋萎縮治療薬の開発を目指したSMAD3 阻害剤SIS3 の結合様式の同定2017
- Author(s)
  中込泉，楠本彩瑛，飯島瑛里香，山乙教之，宮本健史，広野修一
- Organizer
  第45 回構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07899
[Presentation] コンピュータリガンドドッキングと分子動力学シミュレーションによるHexosaminidase A―リガンド複合体の相互作用解析2017
- Author(s)
  中込泉、加藤敦、山乙教之、足立伊左雄、広野修一
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター他
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-26460143
[Presentation] in silico フラグメントマッピングによる新規キマーゼ阻害剤の探索2017
- Author(s)
  小澤　新一郎, 高橋　美貴, 広野　修一
- Organizer
  第３5 回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-15K07899
[Presentation] In silico フラグメントマッピング法を用いた新規PAD4 阻害剤の探索2017
- Author(s)
  片村百々奈，中込泉，山乙教之，広野修一
- Organizer
  第45 回構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07899
[Presentation] ピロリジン型イミノ糖を基盤とした新規GCase高親和性リガンドのデザインとファーマコロジカルシャペロン効果について2016
- Author(s)
  加藤敦、山本亜里紗、友原啓介、足立伊佐雄、渡邊靖香、名取良浩、吉村祐一、中込　泉、広野修一
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26460143
[Presentation] Hexosaminidase Aの高親和性リガンドに対するイン・シリコ相互作用解析2016
- Author(s)
  中込　泉、加藤　敦、山乙　教之、足立伊佐雄、広野修一
- Organizer
  第44回構造活性相関シンポジウム
- Place of Presentation
  京都大学医学部創立百年記念施設
- Year and Date
  2016-11-16
- Data Source
  KAKENHI-PROJECT-26460143
[Presentation] イミノ糖を基盤としたGCase高親和性リガンドの創製とファーマコロジカルシャペロン効果について2016
- Author(s)
  加藤敦、中込　泉、佐藤香純、山本亜里紗、足立伊佐雄、広野修一
- Organizer
  第35回糖質学会年会
- Place of Presentation
  高知市文化プラザ　かるぽーと
- Year and Date
  2016-09-01
- Data Source
  KAKENHI-PROJECT-26460143
[Presentation] Computational study of the interaction of α-1-C-alkyl derivatives of 1,4-dideoxy-1,4-imino-D-arabinitol with β-glucocerebrosidase2015
- Author(s)
  中込　泉、加藤　敦、山乙教之、吉田智喜、足立伊佐雄、広野修一
- Organizer
  第43回構造活性相関シンポジウム
- Place of Presentation
  新潟日報メディアシップ　日報ホール
- Year and Date
  2015-09-27
- Data Source
  KAKENHI-PROJECT-26460143
[Presentation] In silico study on the interaction of high affinity ligand calystegine B2 with β-glucocerebrosidase2015
- Author(s)
  Nakagome, I., Kato, A., Yoshida, T., Yamaotsu, N., Adachi, I., Hirono, S.
- Organizer
  Pacifichem2015
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460143
[Presentation] Similarity analyses of ligand-binding subsites on proteins2015
- Author(s)
  Yamaotsu N., Hirono S.
- Organizer
  PacifiChem2015
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07899
[Presentation] インスリンシグナル増強作用を示す新規化合物CPDAのSHIP2阻害能評価2015
- Author(s)
  梅田知伸、山田彩華、田中信忠、小澤新一郎、広野修一、笹岡利安、豊岡尚樹、合田浩明
- Organizer
  日本薬学会第135年会
- Place of Presentation
  デザイン・クリエイティブセンター神戸（兵庫県、神戸市）
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-24590058
[Presentation] 新規糖尿病治療薬としての選択的SHIP2阻害剤のin silico創薬研究2015
- Author(s)
  小澤新一郎, 合田浩明, 広野修一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸サンボーホール（兵庫県、神戸市）
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-24590058
[Presentation] Calystegine類のβ-glucocerebrosidaseに対する結合親和性とファーマコロジカルシャペロン効果について2014
- Author(s)
  加藤敦、中込泉、中川進平、広野修一、足立伊佐雄
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23590127
[Presentation] Calystegine類のβ-glucocerebrosidaseに対する結合親和性とファーマコロジカルシャペロン効果について2014
- Author(s)
  加藤　敦、中込　泉、中川進平、広野修一、足立伊佐雄
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学他
- Data Source
  KAKENHI-PROJECT-23590127
[Presentation] 新規β-glucocerebrosidase高親和性リガンドcalystegine B_2の結合様式に対するin silico解析2014
- Author(s)
  中込泉、加藤敦、山乙教之、足立伊佐雄、広野修一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23590127
[Presentation] 新規β-glucocerebrosidase高親和性リガンドcalystegine B2の結合様式に対するin silico解析2014
- Author(s)
  中込　泉、加藤　敦、山乙教之、足立伊佐雄、広野修一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学他
- Data Source
  KAKENHI-PROJECT-23590127
[Presentation] 新規糖尿病治療薬としてのSHIP2選択的阻害剤のin silico創薬研究2014
- Author(s)
  小澤新一郎, 合田浩明, 広野修一
- Organizer
  第42回構造活性相関シンポジウム
- Place of Presentation
  くまもと森都心プラザ（熊本県、熊本市）
- Year and Date
  2014-11-13
- Data Source
  KAKENHI-PROJECT-24590058
[Presentation] コンピュータリガンドドッキングによるα-glucosidase阻害剤α-1-C-Butyl-LABのmaltase及びβ-glucosidaseに対する結合様式解析2013
- Author(s)
  中込泉、小関準、山乙教之、合田浩明、広野修一、加藤敦、林恵利奈、足立伊佐雄、今堀龍志、名取良浩、吉村祐一、高畑廣紀
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590127
[Presentation] 新規β-glucocerebrosidase阻害剤calystegine B_2のインシリコ結合様式解析2013
- Author(s)
  中込泉、加藤敦、山乙教之、足立伊佐雄、広野修一
- Organizer
  第41回構造活性相関シンポジウム
- Place of Presentation
  西宮
- Data Source
  KAKENHI-PROJECT-23590127
[Presentation] 次世代型イミノ糖であるα-1-C-alkyl-LABの特性と生物活性について(第2報)2013
- Author(s)
  加藤敦、林恵利奈、足立伊佐雄、今堀龍志、名取良浩、吉村祐一、島岡秀行、中込泉、小関準、広野修一、高畑廣紀
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590127
[Presentation] 次世代型イミノ糖であるα-1-C-alkyl-LABの特性と生物活性について（第2報）2013
- Author(s)
  加藤　敦、林　恵利奈、足立伊佐雄、今堀龍志、名取良浩、吉村祐一、島岡秀行、中込　泉、小関　準、広野修一、高畑廣紀
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590127
[Presentation] 新規β-glucocerebrosidase阻害剤calystegine B2のインシリコ結合様式解析2013
- Author(s)
  中込　泉、加藤　敦、山乙教之、足立伊佐雄、広野修一
- Organizer
  第41回構造活性相関シンポジウム
- Place of Presentation
  関西学院会館
- Data Source
  KAKENHI-PROJECT-23590127
[Presentation] Identification of a new inhibitor of the Golgi system, targeting ADP-ribosylation Factor 1 (Arf1) with potential for cancer therapy2012
- Author(s)
  Ohashi Y, Iijima H, Yamaotsu N, Yamazaki K, Sato S, Okamura M, Sugimoto K, Dan S, Hirono S, Yamori T
- Organizer
  2012AACR Annual Meeting
- Place of Presentation
  USA・シカゴ
- Data Source
  KAKENHI-PROJECT-22240092
[Presentation] Docking and SAR studies of D- and L-isofagomine isomers as humanβ-glucocerebrosidase inhibitors2012
- Author(s)
  Kato, A., Miyauchi, S., Nakagome, I., Yoshimura, Y., Hirono, S., Takahata, H., Adachi, I
- Organizer
  8th AFMC International Medicinal Chemistry Symposium (AIMECS11)
- Place of Presentation
  Keio, Japan
- Data Source
  KAKENHI-PROJECT-23590127
[Presentation] 新規喘息治療薬開発に有用なin silico分子設計法の確立2012
- Author(s)
  若杉昌輝, 合田浩明, 廣瀬友靖, 菅原章公, 山本剛, 塩見和朗, 砂塚敏明, 大村智, 広野修一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] 抗MRSA活性物質Bottromycin類の固相合成研究2012
- Author(s)
  小林豊, 山田健, 井手口哲也, 千成恒, 廣瀬友靖, 小林義典, 合田浩明, 広野修一, 大村智, 砂塚敏明
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] PPARγLBDと三環系PPARγパーシャルアゴニストの相互作用解析2012
- Author(s)
  中込泉, 豊岡尚樹, 峰平大輔, 竹田大輔, 加藤敦, 足立伊左雄, 松谷裕二, 川田耕司, 佐藤謙一, 山乙教之, 合田浩明, 広野修一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] イン・シリコ創薬技術に基づいたヒトセリンラセマーゼ阻害剤の創製研究2012
- Author(s)
  合田浩明, 和田亮吾, 李杰, 帯田孝之, 水口峰之, 森寿, 豊岡尚樹, 広野修一
- Organizer
  第40回構造活性相関シンポジウム
- Place of Presentation
  岡崎
- Data Source
  KAKENHI-PROJECT-24590058
[Presentation] 新規喘息治療薬開発に有用なin silico分子設計法の確立2012
- Author(s)
  若杉昌輝, 合田浩明, 廣瀬友靖, 菅原章公, 山本剛, 塩見和朗, 砂塚敏明, 大村智, 広野修一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] 新規セリンラセマーゼ阻害剤の合成研究2012
- Author(s)
  和田亮吾, 李杰, 合田浩明, 広野修一, 水口峰之, 森寿, 豊岡尚樹
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] 抗MRSAおよび抗VRE活性を有する天然化合物bottromycin A_2の溶液構造決定2012
- Author(s)
  合田浩明, 小林豊, 山田健, 井手口哲也, 菅原章公, 廣瀬友靖, 大村智, 砂塚敏明, 広野修一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] 抗MRSAおよび抗VRE活性を有する天然化合物bottromycin A_2の溶液構造決定2012
- Author(s)
  合田浩明, 小林豊, 山田健, 井手口哲也, 菅原章公, 廣瀬友靖, 大村智, 砂塚敏明, 広野修一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] Identification of a new inhibitor of the Golgi system, targeting ADP-ribosylation Factor 1 (Arf1) with potential for cancer therapy2012
- Author(s)
  Ohashi Y, Iijima H, Yamaotsu N, Yamazaki K, Sato S, Okamura M, Sugimoto K, Dan S, Hirono S, Yamori T
- Organizer
  2012AACR Annual Meeting
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-22240092
[Presentation] PPARγLBDと三環系PPARγパーシャルアゴニストの相互作用解析2012
- Author(s)
  中込泉, 豊岡尚樹, 峰平大輔, 竹田大輔, 加藤敦, 足立伊左雄, 松谷裕二, 川田耕司, 佐藤謙一, 山乙教之, 合田浩明, 広野修一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] Development of a Novel Inhibitor of ADP-ribosylation Factor 1 (Arf1) That Has Potential for Cancer Therapy2012
- Author(s)
  Ohashi Y, Ijima H, Yamaotsu N, Yamazaki K, Okamura M, Sugimoto K, Hirono S, Dan S, Yamori T
- Organizer
  EORTC-NCI-AACR Symposium
- Place of Presentation
  Ireland Dublin
- Data Source
  KAKENHI-PROJECT-22240092
[Presentation] 新規セリンラセマーゼ阻害剤の合成研究2012
- Author(s)
  和田亮吾, 李杰, 合田浩明, 広野修一, 水口峰之, 森寿, 豊岡尚樹
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] ヒトCYP3A4阻害剤の3次元定量的構造活性相関-Structure-based CoMFA-2012
- Author(s)
  半田耕一, 中込泉, 山乙教之, 合田浩明, 広野修一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] 抗MRSA活性物質Bottromycin類の固相合成研究2012
- Author(s)
  小林豊, 山田健, 井手口哲也, 千成恒, 廣瀬友靖, 小林義典, 合田浩明, 広野修一, 大村智, 砂塚敏明
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] A Novel Golgi Disruptor, AMF-26, Targets ADP-ribosylation Factor 1 (Arf1) with Potential for Cancer Therapy2012
- Author(s)
  Ohashi Y, Iijima H, Yamaotsu N, Yamazaki K, Okamura M, Sugimoto K, Hirono S, Dan S, Yamori T
- Organizer
  The 17thJapanese Foundation for Cancer Research International Symposium on Cancer Chemotherapy (ISCC)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22240092
[Presentation] L-アラビノイミノフラノースをベースとした食後過血糖改善薬のデザイン合成研究2012
- Author(s)
  加藤敦、林恵利奈、中川進平、足立伊佐雄、中込泉、小関準、広野修一、名取良浩、今堀龍志、吉村祐一、高畑廣紀
- Organizer
  第31回糖質学会年会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-23590127
[Presentation] Sucrase及びIsomaltaseへのLAB化合物の結合様式に関する理論的研究2012
- Author(s)
  小関準、中込泉、足立伊佐雄、加藤敦、広野修一
- Organizer
  第40回構造活性相関シンポジウム
- Place of Presentation
  岡崎
- Data Source
  KAKENHI-PROJECT-23590127
[Presentation] ヒト酸性キチナーゼを標的とした新規喘息治療薬開発を目指したイン・シリコ創薬研究2012
- Author(s)
  若杉昌輝, 合田浩明, 廣瀬友靖, 菅原章公, 山本剛, 塩見和朗, 砂塚敏明, 大村智, 広野修一
- Organizer
  第40回構造活性相関シンポジウム
- Place of Presentation
  岡崎
- Data Source
  KAKENHI-PROJECT-24590058
[Presentation] ヒトCYP3A4阻害剤の3次元定量的構造活性相関-Structure-based CoMFA-2012
- Author(s)
  半田耕一, 中込泉, 山乙教之, 合田浩明, 広野修一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] Isofagomine類のβ-glucocerebrosidaseに対する結合親和性と構造活性相関について2012
- Author(s)
  加藤敦、中川進平、足立伊佐雄、中込泉、広野修一、吉村祐一、高畑廣紀
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590127
[Presentation] マクロライド骨格をテンプレートとした新規キチナーゼ阻害剤のデザインと合成2011
- Author(s)
  木村紗穂莉, 斎藤佳史, 菅原章公, 廣瀬友靖, 合田浩明, 広野修一, 大村智, 砂塚敏明
- Organizer
  第55回日本薬学会関東支部大会
- Place of Presentation
  千葉
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] アディポネクチン発現低下を抑制するプロポリス成分化合物とPPARγLBDの相互作用解析2011
- Author(s)
  中込泉, 山乙教之, 合田浩明, 広野修一, 津田孝範, 熊澤茂則
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] タンパク質と相互作用する分子フラグメントを同定するプログラムの開発2011
- Author(s)
  山乙教之, 中込泉, 合田浩明, 広野修一
- Organizer
  日本コンピュータ化学会2011秋季年会
- Place of Presentation
  福井
- Year and Date
  2011-11-05
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] 相互作用に重要な水分子を取り込んだキチナーゼ阻害剤のin silico分子設計2011
- Author(s)
  合田浩明, 広野修一
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] タンパク質と相互作用する分子フラグメント探索法の開発2011
- Author(s)
  山乙教之、広野修一
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] マクロライド骨格をテンプレートとした新規キチナーゼ阻害剤のデザインと合成2011
- Author(s)
  木村紗穂莉, 斎藤佳史, 菅原章公, 廣瀬友靖, 合田浩明, 広野修一, 大村智, 砂塚敏明
- Organizer
  第55回日本薬学会関東支部大会
- Place of Presentation
  千葉
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] Rational drug design strategy for future development of asthma medication2011
- Author(s)
  Masaki Wakasugi, Hiroaki Gouda, Tomoyasu Hirose, Yoshihumi Saitoh, Tuyoshi Yamamoto, Kazuro Shiomi, Toshiaki Sunazuka, Satosi Omura, Shuichi Hirono
- Organizer
  The 8th AFMC International Medicinal Chemistry Symposium "Frontier of Medicinal Science"
- Place of Presentation
  東京
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors2011
- Author(s)
  Kato, A., Miyauchi, S., Nakagome, I., Yoshimura, Y., Hirono, S., Takahata, H., Adachi, I.
- Organizer
  8th AFMC International Medicinal Chemistry Symposium (AIMECS11)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590127
[Presentation] ンパク質と相互作用する分子フラグメントを同定するプログラムの開発2011
- Author(s)
  山乙教之, 中込泉, 合田浩明, 広野修一
- Organizer
  日本コンピュータ化学会2011秋季年会
- Place of Presentation
  福井
- Year and Date
  2011-11-05
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] 相互作用に重要な水分子を取り込んだキチナーゼ阻害剤のin silico分子設計2011
- Author(s)
  合田浩明, 広野修一
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] Rational drug design strategy for future development of asthma medication2011
- Author(s)
  Masaki Wakasugi, Hiroaki Gouda, Tomoyasu Hirose, Yoshihumi Saitoh, Tuyoshi Yamamoto, Kazuro Shiomi, Toshiaki Sunazuka, Satosi Omura, Shuichi Hirono
- Organizer
  The 8th AFMC International Medicinal Chemistry Symposium Frontier of Medicinal Science
- Place of Presentation
  東京
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] 津田孝範,熊澤茂則アディポネクチン発現低下を抑制するプロポリス成分化合物とPPARγLBDの相互作用解析2011
- Author(s)
  中込泉, 山乙教之, 合田浩明, 広野修一
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] D-およびL-isofagomine類の合成とグリコシダーゼ阻害活性2011
- Author(s)
  加藤敦、宮内沙織、中川進平、足立伊佐雄、中込泉、広野修一、吉村祐一、高畑廣紀
- Organizer
  第30回日本糖質学会年会
- Place of Presentation
  長岡
- Data Source
  KAKENHI-PROJECT-23590127
[Presentation] ヒト酸性キチナーゼを標的にしたキチナーゼ阻害剤Argifinの理論的分子構造最適化2010
- Author(s)
  合田浩明, 寺嶋真一, 広野修一
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] TRNOE測定、コンピュータリガンドドッキングおよび結合自由エネルギー計算を組み合わせたキチナーゼBとArgifin由来ジペプチド阻害剤の相互作用解析2010
- Author(s)
  合田浩明, 砂塚敏明, 廣瀬友靖, 井口加奈美, 菅原章公, 野口吉彦, 斉藤佳史, 山本剛, 塩見和朗, 大村智, 広野修一
- Organizer
  第38回構造活性相関シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] In silico創薬技術に基づくD-aspartate oxidase-thiolactomycin複合体の構造解析2010
- Author(s)
  中込泉, 山乙教之, 合田浩明, 片根真澄, 本間浩, 広野修一
- Organizer
  第38回構造活性相関シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] 分子重ね合わせ法を用いたLigand-Based Drug Design手法によるcongenericな化合物群の3D-QSARモデルの構築及びその検証2010
- Author(s)
  土井一生, 山乙教之, 合田浩明, 広野修一
- Organizer
  第38回構造活性相関シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2010-10-31
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] The ligand-based drug design method effective for identifying the active conformations and 3-dimensional pharmacophores of congeneric compounds2010
- Author(s)
  Issei Doi, Noriyuki Yamaotsu, Hiroaki Gouch, Shuichi Hirono
- Organizer
  18^<th> Euro QSAR
- Place of Presentation
  Rhodes, Greece
- Year and Date
  2010-09-21
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] TRNOE測定、コンピュータリガンドドッキングおよび結合自由エネルギー計算を組み合わせたキチナーゼBとArgifin由来ジペプチド阻害剤の相互作用解析2010
- Author(s)
  合田浩明, 砂塚敏明, 廣瀬友靖, 井口加奈美, 菅原章公, 野口吉彦, 斉藤佳史, 山本剛, 塩見和朗, 大村智, 広野修一
- Organizer
  第38回構造活性相関シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] 分子重ね合わせ法を用いたLigand-Based Drug Design手法によるcongenericな化合物群の3D-QSARモデルの構築及びその検証2010
- Author(s)
  土井一生, 山乙教之, 合田浩明, 広野修一
- Organizer
  第38回構造活性相関シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2010-10-31
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] ヒト酸性キチナーゼを標的にしたキチナーゼ阻害剤Argifinの理論的分子構造最適化2010
- Author(s)
  合田浩明, 寺嶋真一, 広野修一
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] In silico創薬技術に基づくD-aspartate oxidase-thiolactomycin複合体の構造解析2010
- Author(s)
  中込泉, 山乙教之, 合田浩明, 片根真澄, 本間浩, 広野修一
- Organizer
  第38回構造活性相関シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] ヒト酸性キチナーゼに対して特異性を有するArgifin誘導体の論理的分子設計2009
- Author(s)
  合田浩明, 寺嶋真一, 広野修一
- Organizer
  第37回構造活性相関シンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-11-12
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] In Silico創薬技術に基づくStructure-Based Drug Designの実際2009
- Author(s)
  広野修一
- Organizer
  日本ヒトプロテオーム機構第7回大会
- Place of Presentation
  東京
- Year and Date
  2009-07-28
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] NMR 測定と高温分子動力学計算を組み合わせた抗生物質Bottromycin A2 の絶対構造決定2009
- Author(s)
  合田浩明, 島村寛章, 長井賢一郎, 廣瀬友靖, 小林豊, 砂塚敏明, 大村智, 広野修一
- Organizer
  日本薬学会第129 年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19590043
[Presentation] ヒト酸性キチナーゼに対して特異性を有するArgifin誘導体の論理的分子設計2009
- Author(s)
  合田浩明, 寺嶋真一, 広野修一
- Organizer
  第37回構造活性相関シンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-11-12
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] 3D-QSAR MODELS FOR THE PPARS AGONISTS WITH DUE REGARD TO MEMBRANE TRANSPORT2009
- Author(s)
  S.Hirono, I.Nakagome, N.Yamaotsu, H.Gouda
- Organizer
  Frontiers in Medicinal Chemistry
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2009-10-05
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] In silico 創薬技術を用いたキチナーゼ阻害剤Argifinの分子構造最適化2008
- Author(s)
  合田浩明, 広野修一
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-19590043
[Presentation] ヒト酸性キチナーゼを標的としたキチナーゼ阻害剤Argifinの理論的分子構造最適化2008
- Author(s)
  寺嶋真一, 合田浩明, 広野修一
- Organizer
  第27回メディシナルケミストリーシンポジウム
- Place of Presentation
  大阪
- Year and Date
  2008-11-26
- Data Source
  KAKENHI-PROJECT-19590043
[Presentation] In silico創薬技術を用いた新規キチナーゼ阻害剤の論理的分子設計2008
- Author(s)
  合田浩明, 広野修一
- Organizer
  北里大学薬学部公開シンポジウム(ハイテクリサーチ・シンポジウム)創薬シーズ-発見から応用へ-
- Place of Presentation
  東京
- Year and Date
  2008-02-22
- Data Source
  KAKENHI-PROJECT-19590043
[Presentation] NMRおよび計算化学手法を用いたキチナーゼB とArgifin 由来ジペプチド阻害剤の相互作用解析2008
- Author(s)
  合田浩明, 井口加奈美, 菅原章公, 山本剛, 廣瀬友靖, 塩見和朗, 砂塚敏明, 大村智, 広野修一
- Organizer
  第27回メディシナルケミストリーシンポジウム
- Place of Presentation
  大阪
- Year and Date
  2008-11-26
- Data Source
  KAKENHI-PROJECT-19590043
[Presentation] In silico analysis of interaction between PI3K and its potent inhibitor ZSTK4742007
- Author(s)
  Satoh H, Koshimizu I, Yoshimi H, Watanabe T, Yaguchi S, Matsuno T, Gouda H, Yamori T, Hirono S
- Organizer
  6th AFMC International Medicinal Chemistry Sympojium
- Place of Presentation
  Istanbul, Turkey
- Data Source
  KAKENHI-PROJECT-19590043
[Presentation] SYBYL Zapプログラムを用いたMM/PBSA結合自由エネルギー計算によるドッキングポーズ選択の有効性2007
- Author(s)
  山乙教之、木村敏郎、広野修一
- Organizer
  第35回構造活性相関シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-11-16
- Data Source
  KAKENHI-PROJECT-18590037
[Presentation] キチナーゼBに対するペプチド性阻害剤Argifin の相互作用解析とその誘導体の論理的分子設計2007
- Author(s)
  合田浩明, 広野修一
- Organizer
  第35回構造活性相関シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-11-16
- Data Source
  KAKENHI-PROJECT-19590043
[Presentation] Estimation of the three-dimensional pharmacophores and binding conformations regarding ligands to human OCT1 and those to rat OCT1 using ligand-based drug design methods2006
- Author(s)
  Hirono, S., Sone, D., Nakagome, I
- Organizer
  The 16th European Symposium on QSAR and Modelling
- Place of Presentation
  Italy
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590037
[Presentation] Ligand-Based Drug Design手法を用いた3D-QSAR解析:ヒトとラットOCT1を中心に2006
- Author(s)
  広野修一
- Organizer
  第21回日本薬物動態学会
- Place of Presentation
  東京(船堀)
- Year and Date
  2006-11-30
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590037
[Presentation] α-glucosidase 阻害剤 α-1-C-Butyl-LAB のイソマルターゼに対する結合様式解析
- Author(s)
  中込　泉、小関　準、加藤　敦、山乙教之、足立伊佐雄、広野修一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学他
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460143
[Presentation] β-glucocerebrosidaseに対する高親和性リガンドcalystegine B2類縁体の計算化学的相互作用解析
- Author(s)
  中込　泉、加藤　敦、山乙教之、足立伊佐雄、広野修一
- Organizer
  第42回構造活性相関シンポジウム
- Place of Presentation
  くまもと森都心プラザ
- Year and Date
  2014-11-13 – 2014-11-14
- Data Source
  KAKENHI-PROJECT-26460143
[Presentation] 新規インスリン抵抗性改善に基づく２型糖尿病治療薬の創製
- Author(s)
  高原理行，市原克則，和田努，恒枝宏史，笹岡利安，広野修一，梅田知伸，田中信忠，合田浩明，豊岡尚樹
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24590058
[Presentation] 新規糖尿病治療薬としてのSHIP2阻害剤のin silico創薬研究
- Author(s)
  小澤新一郎、中作菜穂、合田浩明、広野修一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24590058
[Presentation] GCase高親和性リガンドである1-N型イミノ糖の結合親和性とファーマコロジカルシャペロン効果について
- Author(s)
  加藤敦、山本亜里紗、中川進平、足立伊佐雄、中込泉、広野修一
- Organizer
  第33回糖質学会年会
- Place of Presentation
  名古屋大学豊田講堂
- Year and Date
  2014-08-10 – 2014-08-12
- Data Source
  KAKENHI-PROJECT-26460143
[Presentation] ジアシルグリセロールアシル基転移酵素-1阻害剤のLigand-Based Drug Design
- Author(s)
  若杉昌輝，合田浩明，平野遼太郎, 小林健一, 古源寛，広野修一
- Organizer
  第41回構造活性相関シンポジウム
- Place of Presentation
  西宮
- Data Source
  KAKENHI-PROJECT-24590058

1. YAMAOTSU Noriyuki (60230322)

# of Collaborated Projects: 13 results

# of Collaborated Products: 35 results
2. NAKAGOME Izumi (30237242)

# of Collaborated Projects: 11 results

# of Collaborated Products: 20 results
3. GOUDA Hiroaki (60276160)

# of Collaborated Projects: 10 results

# of Collaborated Products: 76 results
4. MATSUSHITA Yasuo (40050653)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
5. MORIGUCHI Ikuo (90050343)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. ADACHI Isao (30151070)

# of Collaborated Projects: 3 results

# of Collaborated Products: 31 results
7. KATO Atsushi (60303236)

# of Collaborated Projects: 3 results

# of Collaborated Products: 33 results
8. ISHII Satoshi (00222935)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. YAMORI Takao (60200854)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
10. IMAIZUMI Yuji (60117794)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. YAMAMURA Hisao (80398362)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. HIGUCHI Tsunehiko (50173159)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. ASAI Kiyofumi (70212462)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. SUGIYAMA Yuichi (80090471)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. KUSUHARA Hiroyuki (00302612)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. SUZUKI Hiroshi (80206523)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. DAN Shingo (70332202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
18. KAWADA Manabu (20300808)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. NAKAMURA Hiroyuki (30274434)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SHIINA Isamu (40246690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KOJIMA Naoto (90420413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. OHYA Susumu (70275147)

# of Collaborated Projects: 1 results

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23. TAKAHATA Hiroki (00109109)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
24. ANZAI Kazunori (70128643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. AOYAGI Haruhiko (80037267)

# of Collaborated Projects: 1 results

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26. NAGANO Tetsuo (20111552)

# of Collaborated Projects: 1 results

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27. MAEDA Kazuya (00345258)

# of Collaborated Projects: 1 results

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28. 中川崇子 (10050642)

# of Collaborated Projects: 1 results

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29. 名取良浩 (50584455)

# of Collaborated Projects: 1 results

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30. 鈴木良明 (80707555)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. IMAHORI Tatsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. KOIZUMI Yukio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. NAGASE Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. FUJII Hideaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. HIRAYAMA Shigeto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 砂塚敏明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 真板宣夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 谷口寿章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 笹岡利安

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 恒枝宏史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 和田努

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIRONO Shuichi 広野 修一

広野 修一 ヒロノ シユウイチ

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Development of in silico fragment-based drug design method for rational drug discoveryPrincipal Investigator

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In silico drug design study targeting CRK-C3G interaction for future development of anticarcinogenic agentPrincipal Investigator

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3D-pharmacophore analyses of transporter ligands for drug discovery studies in consideration of pharmacokineticsPrincipal Investigator

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Three-dimensional structure-activity relationships of drugs induced cardiovascular side effects (prolongation in the QT interval)Principal Investigator

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HIRONO Shuichi 広野修一

広野修一ヒロノシユウイチ