HOSHINO Tsutomu 星野力

… Alternative Names

星野力ホシノツトム

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Researcher Number	30165542
Other IDs
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Affiliation (based on the past Project Information) *help	2007: 新潟大, 自然科学系, 教授 2005 – 2006: Niigata University, Institute of Science and Technology, Professor, 自然科学系, 教授 1996 – 2006: 新潟大学, 農学部, 教授 1994: 新潟大学, 農学部, 助教授
Review Section/Research Field	Principal Investigator Bioproduction chemistry/Bioorganic chemistry / Bioproduction chemistry/Bioorganic chemistry Except Principal Investigator Bioproduction chemistry/Bioorganic chemistry / Bioproduction chemistry/Bioorganic chemistry / General medical chemistry / 医薬分子機能学
Keywords	Principal Investigator ホペン / スクアレン / squalene / site-directed mutagenesis / ラノステロール / hopene / triterpene / トリテルペン / Alicyclobacillus acidocaldarius / 部位特異的変異 … More / diterpene / lanosterol / oxidosqualene / オキシドスクアレン / 非天然型アミノ酸 / unnatural amino acid / Mycobacterium tuberculosis / biosynthesis / スクアレン合成酵素 / substrate specificity / Mycobacterium tuberculosin / incorporation of unnatural amino acid / genetic code / alteration of terpene cyclase / terpenoids / dorimane / sesquiterpne / π-interaction / cation / halimane / Mycobacterium tuerculosis / ジテルペン / 結核菌 / 生合成 / mutated enzyme / terpene cyclase / キメラ型酵素 / Alicycobaccilus acidocaldarius / 酵素改変 / テルペン環化酵素 / cyclase / トリテルペン環化酵素 / QW MOTIF / TRITERPENE CYCLASE / MARKOVNIKOV RULE / SITE-DIRECTED MUTAGENESIS / THTRAHYMANOL / HOPENE / SQUALENE / 環化酵素 / マルコフニコフ則 / テトラヒマノール / フルオロフェニルアラニン / π / カチオン / エポキシダンマラン / イネ … More Except Principal Investigator biosynthesis / 生合成 / NF-Y / スクアレン・エポキシダーゼ / スクアレン / コレステロール / スクアレン・エポキシダーゼ(SE) / P450 oxygenase / cyclase / gene cluster / terpenoid / P450酸化酵素 / 環化酵素 / 遺伝子クラスター / テルペノイド / squarene / tetraterpene / biosynthetic intermediate / cyclization mechanism / terpene cyclase / diterpene / 非天然型トリテルペン / スクアレン-ホペン環化酵素 / アフィジコリンの環化機構 / テルペンテトリエン / ヤマブシタケ / 環化酵素遺伝子 / フシコクシン / テルペンテシン / アフィジコリン / サイアタジエン / エリナシン / フォマクチン / テトラテルペン / 生合成中間体 / 環化機構 / テルペン環化酵素 / ジテルペン / membrane binding domain / transcription factor / SREBP (sterol regulatory element binding protein) / transcriptional regulation / cholesterol / lanosterol synthase / squalene epoxidase / D8S508 / 染色体8 / プロモーター領域 / 発現調節 / HeLa細胞 / 遺伝子構造(イントロン-エクソン構成) / 転写調整 / 膜結合領域 / 転写因子 / SREBP / 転写調節 / ラノステロール合成酵素 / Growth inhibition / Squalene synthase (SS) / Antifungal drug / Cloning / Inhibitor / Yeast transformant / Lanosterol synthase (LS) / Squalene epoxidase (SE) / スクアレンエポキシダーゼ / バイオセンサー / スクリーニング / 高脂血症 / 動脈硬化 / 生育阻害 / スクアレン合成酵素(SS) / 抗真菌剤 / クローニング / 阻害剤 / 酵母トランスフォーマント / ラノステロール合成酵素(LS) Less

結核菌で見いだされた新規ジテルペンの抗マクロファージ作用とケミカルバイオロジーPrincipal Investigator
- Principal Investigator
  
  星野力
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Niigata University
真核及び原核生物由来スクアレン環化酵素の触媒機構の比較研究Principal Investigator
- Principal Investigator
  
  星野力
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Niigata University
Studies on production and improvement of terpenoids using biosynthetic gene cluster in fungi and plants.
- Principal Investigator
  
  SASSA Takeshi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Yamagata University
Functional analyses of terpene-related biosynthetic enzymes and creaion of novel cyclasesPrincipal Investigator
- Principal Investigator
  
  HOSHINO Tsutomu
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Niigata University
Scientific research on elucidation of terpene-cyclic reactions in the biosynthesis of bioactive microbial terpenoids.
- Principal Investigator
  
  SASSA Takeshi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Yamagata University
Creation of unnatural natural products by the chimera type cyclase of squalene and oxidosqualene cyclasesPrincipal Investigator
- Principal Investigator
  
  HOSHINO Tsutomu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  NIIGATA UNIVERSITY
INVESTIGATION ON THE SQUALENE CYCLASE ON THE BASES OF ORGANIC CHEMISTRY AND MOLECULAR BIOLOGYPrincipal Investigator
- Principal Investigator
  
  HOSHINO Tsutomu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  NIIGATA UNIVERSITY
Bioorganic studies on the recogniton mechanism of the methyl groups of the substrate skeleton by squalene and oxidosqualene cyclasesPrincipal Investigator
- Principal Investigator
  
  HOSHINO Tsutomu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  NIIGATA UNIVERSITY
Structure and Regulation of Cholesterol Biosynthesis
- Principal Investigator
  
  ONO Teruo
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Niigata University
REGULATION OF SQUALENE EPOXIDASE EXPRESSION AND THE ENZYME EVOLUTION
- Principal Investigator
  
  ONO Teruo
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  NIIGATA UNIVERSITY

All 2007 2005 2004

All Journal Article

[Journal Article] Production of epoxydammaranes by the enzymatic reactions of (3R)- and (3S)-2,3-squalene diols and those of 2,3 : 22,23-dioxidosqualenes with recombinant squalene cyclase. Mechanistic insight into the polycyclization reactions2007
- Author(s)
  Hoshino, T.
- Journal Title
  
  Org. Biomol. Chem. 5
  
  Pages: 792-801
- Data Source
  KAKENHI-PROJECT-18380072
[Journal Article] Production of epoxydammaranes by the enzymatic reactions of (3R)-and (3S)-2,3-squalene diols and those of 2,3 : 22,23-dioxidosqualenes with recombinant aqualene cyclase.2007
- Author(s)
  Hoshino, T. et al.
- Journal Title
  
  Org. Biomol. Chem. 5・5
  
  Pages: 792-801
- Data Source
  KAKENHI-PROJECT-16208012
[Journal Article] Enzymatic cyclizations of squalene analogs with threo- and erythro-diols at the 6,7-and 10,11-positions by recombinat squalene cyclase. Trapping of carbocation intermediates and mechanistic insights into the product and substrate specificities.2005
- Author(s)
  T.Abe, T.Hoshino
- Journal Title
  
  Org.Biomol.Chem. 3
  
  Pages: 3127-3139
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380081
[Journal Article] Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton2005
- Author(s)
  Chiaki Nakano, Tomoo Okamura, Tsutomu Sato, Tohru Dairi, Tsutomu Hoshino
- Journal Title
  
  Chem.Commun. 4
  
  Pages: 1016-1018
- NAID
  120006745822
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380081
[Journal Article] Enzymatic cyclizations of squalene analogs with threo-and erythro-diols at the 6,7-and 10,11-positions by recombinat squalene cyclase. Trapping of carbocation intermediates and mechanistic insights into the product and substrate specificities.2005
- Author(s)
  Abe, T., Hoshino, T.
- Journal Title
  
  Org.Biomol.Chem. 3
  
  Pages: 3127-3139
- Data Source
  KAKENHI-PROJECT-16208012
[Journal Article] Enzymatic cyclizations of squalene analogs with threo- and erythro-diols at the 6,7- and 10,11-positions by recombinat squalene cyclase. Trapping of carbocation intermediates and mechanistic insights into the product and substrate specificities.2005
- Author(s)
  T.Abe, T.Hoshino
- Journal Title
  
  Org.Biomol.Chem. 3
  
  Pages: 3127-3139
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380081
[Journal Article] Enzymatic cyclization reactions of geraniol, famesol and geranylgeraniol, and those of truncated squalene analogs having C20 and C25 by recombinant squalene cyclase2004
- Author(s)
  Hoshino, T.
- Journal Title
  
  Org.Biomol.Chem. 3
  
  Pages: 2650-2657
- Data Source
  KAKENHI-PROJECT-15380081
[Journal Article] Squalene-hopene Cyclase : Final Deprotonation Reaction, conformational Analysis for the Cyclization of 3(R, S)-2,3-Oxidosqualene and Further Evidence for the requirement of isopropylidene moiety for initiating the polycyclization reaction.2004
- Author(s)
  Hoshino, T. et al.
- Journal Title
  
  Org.Biomol.Chem. 2
  
  Pages: 1456-1470
- Data Source
  KAKENHI-PROJECT-15380081
[Journal Article] Deletion of the Gly600 residue of Alicyclobacillus acidocaldarius squalene cyclase alters the substrate specificity into that ofeukaryotic type cyclase specific to (3S)-2,3-oxidosqualene.2004
- Author(s)
  Hoshino, T.
- Journal Title
  
  Angew.Chem.Int.Ed. 43
  
  Pages: 6700-6703
- Data Source
  KAKENHI-PROJECT-15380081
[Journal Article] Deletion of the Gly600 residue of Alicyclobacillus acidocaldarius squalene cyclase alters the substrate specificity into that ofeukaryotic type cyclase specific to (3S)-2,3-oxidosqualene.2004
- Author(s)
  Tsutomu Hoshino, Kunio Shimizu, Tsutomu Sato
- Journal Title
  
  Angew.Chem.Int.Ed. 43
  
  Pages: 6700-6703
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380081
[Journal Article] Squalene-hopene Cyclase : Final Deprotonation Reaction, Conformational Analysis for the Cyclization of 3(R,S)-2,3-Oxidosqualene and Further Evidence for the requirement of isopropylidene moiety for initiating the polycyclization reaction.2004
- Author(s)
  Tsutomu Hoshino, Schin-ichi Nakano, Tomohiro Kondo, Tsutomu Sato, Aya Miyoshi
- Journal Title
  
  Org.Biomol.Chem. 2
  
  Pages: 1456-1470
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380081
[Journal Article] Enzymatic cyclization reactions of geraniol, farnesol and geranylgeraniol, and those of truncated squalene analogs having C20 and C25 by recombinant squalene cyclase2004
- Author(s)
  Tsutomu Hoshino, Yuko Kumai, Isao Kudo, Shin-ichi Nakano, Shumi Ohashi
- Journal Title
  
  Org.Biomol.Chem. 2
  
  Pages: 2650-2657
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380081
[Journal Article] Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius2004
- Author(s)
  Tsutomu Sato, Masanori Koda, Tsutomu Hoshino
- Journal Title
  
  Biosci.Biotechnol.Biochem 68
  
  Pages: 728-738
- NAID
  10013143371
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380081
[Journal Article] Deletion of the Gly600 residue of Alicyclobacillus acidocaldarius squalene cyclase alters the substrate specificity into that ofeukaryotic type cyclase specific to (3S)-2,3-oxidosqualene2004
- Author(s)
  T.Hoshino
- Journal Title
  
  Angew.Chem.Int.Ed. 43
  
  Pages: 6700-6703
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380081
[Journal Article] Squalene-hopene cyclase : insight into the role of the methyl group on the squalene backbone upon the polycyclization cascade. Enzymatic cyclization products of squalene aalogs lacking a 26-methyl group and possessing a methyl group at C(7) or C(11)2004
- Author(s)
  Shin-ichi Nakano, Shumi Ohashi, Tsutomu Hoshino
- Journal Title
  
  Org.Biomol.Chem. 2
  
  Pages: 2012-2022
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380081
[Journal Article] Squalene-hopene Cyclase : Final Deprotonation Reaction, Conformational Analysis for the Cyclization of 3(R,S)-2,3-Oxidosqualene and Further Evidence for the requirement of isopropylidene moiety for initiating the polycyclization reaction2004
- Author(s)
  Tsutomu Hoshino
- Journal Title
  
  Org.Biomol.Chem. 2
  
  Pages: 1456-1470
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380081
[Journal Article] Enzymatic cyclization reactions of geraniol, farnesol and geranylgeraniol, and those of truncated squalene analogs having C20 and C25 by recombinant squalene cyclase2004
- Author(s)
  T.Hoshino
- Journal Title
  
  Org.Biomol.Chem. 2
  
  Pages: 2650-2657
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380081

1. ONO Teruo (00000927)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. KUMAGAI Hidetoshi (20281008)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SAKAKIBARA Jun (90242403)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. FUJII Hiroshi (90165340)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SASSA Takeshi (80023456)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. OIKAWA Hideaki (00185175)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KATO Nobuo (50150537)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. DAIRI Tohru (70264679)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. TOYOMASU Tomonobu (60272085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMANE Hisakazu (80090520)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HOSHINO Tsutomu 星野 力

星野 力 ホシノ ツトム

Research Projects

Research Products

Co-Researchers

結核菌で見いだされた新規ジテルペンの抗マクロファージ作用とケミカルバイオロジーPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

真核及び原核生物由来スクアレン環化酵素の触媒機構の比較研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on production and improvement of terpenoids using biosynthetic gene cluster in fungi and plants.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analyses of terpene-related biosynthetic enzymes and creaion of novel cyclasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Scientific research on elucidation of terpene-cyclic reactions in the biosynthesis of bioactive microbial terpenoids.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Creation of unnatural natural products by the chimera type cyclase of squalene and oxidosqualene cyclasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

INVESTIGATION ON THE SQUALENE CYCLASE ON THE BASES OF ORGANIC CHEMISTRY AND MOLECULAR BIOLOGYPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Bioorganic studies on the recogniton mechanism of the methyl groups of the substrate skeleton by squalene and oxidosqualene cyclasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structure and Regulation of Cholesterol Biosynthesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

REGULATION OF SQUALENE EPOXIDASE EXPRESSION AND THE ENZYME EVOLUTION

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Production of epoxydammaranes by the enzymatic reactions of (3R)- and (3S)-2,3-squalene diols and those of 2,3 : 22,23-dioxidosqualenes with recombinant squalene cyclase. Mechanistic insight into the polycyclization reactions2007

Author(s)

Journal Title

Data Source

[Journal Article] Production of epoxydammaranes by the enzymatic reactions of (3R)-and (3S)-2,3-squalene diols and those of 2,3 : 22,23-dioxidosqualenes with recombinant aqualene cyclase.2007

Author(s)

Journal Title

Data Source

[Journal Article] Enzymatic cyclizations of squalene analogs with threo- and erythro-diols at the 6,7-and 10,11-positions by recombinat squalene cyclase. Trapping of carbocation intermediates and mechanistic insights into the product and substrate specificities.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton2005

Author(s)

HOSHINO Tsutomu 星野力

星野力ホシノツトム