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nakagama hitoshi  中釜 斉

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NAKAGAMA Hitoshi  中釜 斉

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Researcher Number 30198030
Other IDs
Affiliation (Current) 2020: 国立研究開発法人国立がん研究センター, その他部局等, 理事長
Affiliation (based on the past Project Information) *help 2016: 国立がん研究センター, 理事長
2005: 国立がんセンター(研究所及び東病院臨床開発センター), 生化学部, 部長
2004: Biochemistry Div., National Cancer Center Research Intitute, Chief, 生化学部, 部長
2003: 国立がんセンター研究所, 生化学部, 部長
2000 – 2003: 国立がんセンター, 研究所・生化学部, 部長 … More
2000: BIOCHEMISTRY DIVISION, NATIONAL CANCER CENTER RESEARCH INSTITUTE CHIEF, 生化学部, 部長
1999: 国立がんセンター研究所, 研究所・生化学部, 部長
1997 – 1998: 国立がんセンター, 研究所・生化学部, 部長
1996: 国立がんセンター研究所, 発がん研究部, 室長 Less
Review Section/Research Field
Principal Investigator
Biological Sciences
Except Principal Investigator
Functional biochemistry / Pathological medical chemistry
Keywords
Principal Investigator
PhIP / heterocyclic amines / ACF / Apc / methylation / AOM / Colon carcinogenesis / colon carcinogenesis / HCA / dysplastic ACF … More / animal model / mutation spectrum / 大腸がん / 大腸炎 / ゲノム解析 / copy number aberration / BAC-CGHアレイ / オリゴ-CGHアレイ / beta catenin / Loss of heterozygosity (LOH) / Loss of heterozygosity(LOH) / mammary carcinogenesis / beta-catenin / loss of heterozygosity (LOH) / PhIp / 大腸がんモデル / colon carcinoenesis / 階層型クラスター解析 / 遺伝子発現解析 / 変異スペクトラム / 発がん要因 / 発がん予防 / ラット / Dysplastic ACF / cancer susceptibility / HCAs / gene expression profile / β-catenin / colon carcinogensies / hierarchical gene clustering analysis / gene expression analysis … More
Except Principal Investigator
PhIP / Brca-1 / Brca-2 / PP2AB / 染色体マッピング / LOH / 乳がん / microsatellite / aberrant crypt focus / 発がん感受性 / Apc / β-カテニン / 突然変異スペクトル / p53 / 繰り返しDNA / 4重鎖DNA / 複製フォーク / 反復配列 / ミニサテライト / 染色体不安定性 / テロメア / ミニサテライ / 繰返しDNA / Repetive Sequences / Ouadruplex DNA / DNA Replication Fork / Minisatellite / Genomic Instability / Telomere / 癌 / 分子腫瘍学 Less
  • Research Projects

    (7 results)
  • Research Products

    (19 results)
  • Co-Researchers

    (15 People)
  •  Elucidation of chemoresistance of refracory cancer by single-cell gene expression analyses

    • Principal Investigator
      Okamoto Koji
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      National Cancer Center Japan
  •  環境因子による大腸発がんモデルを用いたがんの浸潤性進展過程のゲノム網羅的解析Principal Investigator

    • Principal Investigator
      中釜 斉
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  Restoring DNA replication fork arrest within G-rich repetitive sequences by UP1 protein

    • Principal Investigator
      FUKUDA Hirokazu
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      National Cancer Center (Research Institute)
  •  Specificity of mutation spectrum and gene expression profiles induced by environmental carcinogensPrincipal Investigator

    • Principal Investigator
      NAKAGAMA Hitoshi
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Cancer Center Research Institute
  •  GENETIC ALTERATIONS DURING CARCINOGENESIS INDUCED BY ENVIRONMENTAL CARCINOGENSPrincipal Investigator

    • Principal Investigator
      NAKAGAMA Hitoshi
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      NATIONAL CANCER CENTER RESEARCH INSTITUTE
  •  環境発がん物質の遺伝子変異特性

    • Principal Investigator
      長尾 美奈子
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  発がん過程における遺伝子変異

    • Principal Investigator
      長尾 美奈子
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

All 2016 2014 2006 2005 2004 2002 2000 Other

All Journal Article Book

  • [Book] Carcinogenicity in Animals; In Food Borne Carcinogens.(Nagao M, Sugimura T2000

    • Author(s)
      Nakagama H
    • Publisher
      John Wiley & Sons, Ltd, New York
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12213151
  • [Journal Article] Establishment and Characterization of an In Vitro Model of Ovarian Cancer Stem-like Cells with an Enhanced Proliferative Capacity.2016

    • Author(s)
      Ishiguro T, Sato A, Ohata H, Ikarashi Y, Takahashi R, Ochiya T, Yoshida M, Tsuda H, Onda T, Kato T, Kasamatsu T, Enomoto T, Tanaka K, Nakagama H, Okamoto K.
    • Journal Title

      Cancer Res.

      Volume: 76 Pages: 150-160

    • DOI

      10.1158/0008-5472.can-15-0361

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K14390, KAKENHI-PROJECT-26870877, KAKENHI-PROJECT-25293338, KAKENHI-PROJECT-26293073, KAKENHI-PROJECT-15K15598
  • [Journal Article] MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells.2014

    • Author(s)
      Sakai H, Sato A, Aihara Y, Ikarashi Y, Midorikawa Y, Nakagama H, Okamoto K.
    • Journal Title

      Cancer Sci.

      Volume: 105 Pages: 425-430

    • DOI

      10.1111/cas.12380

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23591972, KAKENHI-PROJECT-26293073
  • [Journal Article] Molecular mechanisms for maintenance of G-rich short tandem repeats capable of adopting G4 DNA structures2006

    • Author(s)
      Nakagama H, et al.
    • Journal Title

      Mutation Research (in press)

    • Data Source
      KAKENHI-PROJECT-17013092
  • [Journal Article] Up-regulation of the hnRNPA1 gene in human colorectal cancer.2005

    • Author(s)
      Ushigome M, Nakagama H, et al.
    • Journal Title

      International Journal of Oncology 26

      Pages: 635-640

    • Data Source
      KAKENHI-PROJECT-12213151
  • [Journal Article] Differential staining of dysplastic aberrant crypt foci in the colon facilitates prediction of carcinogenic potentials of chemicals in rats.2005

    • Author(s)
      Ochiai M, Nakagama H, et al.
    • Journal Title

      Cancer Letters 220

      Pages: 67-74

    • Data Source
      KAKENHI-PROJECT-12213151
  • [Journal Article] Genetic alteration of poly(ADP-ribose)polymerase-1 in human germ cell tumors.2005

    • Author(s)
      Shiokawa M, Nakagama H, et al.
    • Journal Title

      Japanese Journal of Clinical Oncology 35

      Pages: 97-102

    • Data Source
      KAKENHI-PROJECT-12213151
  • [Journal Article] Modeling human colon cancer in rodents using a food-borne carcinogen, PhIP2005

    • Author(s)
      Nakagama H, et al.
    • Journal Title

      Cancer Science 96

      Pages: 627-636

    • NAID

      10017090891

    • Data Source
      KAKENHI-PROJECT-17013092
  • [Journal Article] Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent.2005

    • Author(s)
      Shibata A, Nakagama H, et al.
    • Journal Title

      Oncogene 24

      Pages: 1328-1337

    • Data Source
      KAKENHI-PROJECT-12213151
  • [Journal Article] Poly(ADP-ribose) polmerase-1 gene in human tumor cell lines : its expression and structural alterations.2004

    • Author(s)
      Masutani M, Nakagama H, et al.
    • Journal Title

      Proceedings of the Japan Academy, Ser.B 80

      Pages: 114-118

    • Data Source
      KAKENHI-PROJECT-12213151
  • [Journal Article] Nuclear export signal in CDC25B2004

    • Author(s)
      Uchida S, Nakagama H, et al.
    • Journal Title

      Biochemical and Biophysical Research Communications 316

      Pages: 226-232

    • Data Source
      KAKENHI-PROJECT-12213151
  • [Journal Article] Efficient mapping and characterization of the structure of deletion mutation by Southern blot analysis using oligo DNA probe in gpt delta mice.2004

    • Author(s)
      Shibata A, Nakagama H, et al.
    • Journal Title

      Environmental Molecular Mutagenesis 43

      Pages: 204-207

    • Data Source
      KAKENHI-PROJECT-12213151
  • [Journal Article] LRP130, a single-stranded DNA/RNA binding protein, plays a role in the nucleo-cytoplasmic export of mRNA.2004

    • Author(s)
      Tsuchiya N, Nakagama H, et al.
    • Journal Title

      Biochemical and Biophysical Research Communications 317

      Pages: 736-743

    • Data Source
      KAKENHI-PROJECT-12213151
  • [Journal Article] Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.2004

    • Author(s)
      Fujiwara K, Nakagama H, et al.
    • Journal Title

      Carcinogenesis 25

      Pages: 1495-1505

    • Data Source
      KAKENHI-PROJECT-12213151
  • [Journal Article] Science of food borne mutagens/Carcinogens, heterocyclic amines : How should we deal with unnegligible risk of unavoidable exposure to carcinogens under ordinarily life style2004

    • Author(s)
      Sugimura T, Nakagama H, et al.
    • Journal Title

      Cancer Science 95

      Pages: 290-299

    • Data Source
      KAKENHI-PROJECT-12213151
  • [Journal Article] A rat colon cancer model induced by 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine, PhIP2002

    • Author(s)
      Nakagama H, et al.
    • Journal Title

      Mutation Research 506-507

      Pages: 137-144

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12213151
  • [Journal Article] A rat colon cancer model induced by 2-amino-1-methyl-6-phenylimidazo(4,5-6]pyridine, PhIP.2002

    • Author(s)
      Nakagama H, et al.
    • Journal Title

      Mutat.Res. 506・507

      Pages: 137-144

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12213151
  • [Journal Article] Carcinogenicity in Animals; In Food Borne Carcinogens2000

    • Author(s)
      Nakagama H.
    • Journal Title

      Edited by Nagao M. and Sugimura T., John Wiley Sons, Ltd, New York

      Pages: 256-269

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12213151
  • [Journal Article] Poly ADP-ribosylation in relation to cancer and autoimmune disease.

    • Author(s)
      Masutani M, Nakagama H, et al.
    • Journal Title

      In : Poly(ADP-ribosyl)ation, Edited by Alexander Burkle. Cell Mol Life Sci. (in press)

    • Data Source
      KAKENHI-PROJECT-12213151
  • 1.  OCHIAI Masako (90150200)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 2.  UBAGAI Tsuneyuki (10311416)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  長尾 美奈子 (40100151)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  牛島 俊和 (90232818)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  FUKUDA Hirokazu (60300943)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  Okamoto Koji (80342913)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 7.  KATO Mamoru (40391916)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  豊田 実 (70270676)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  今井 裕 (70300944)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  稲森 英明 (00311415)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  MIDORIKAWA Yutaka
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  高橋 陵宇
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  榎本 隆之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  仲 哲治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  石黒 竜也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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