OKAMOTO Koji 岡本康司

… Alternative Names

Researcher Number	80342913
Other IDs
External Links
Affiliation (Current)	2020: 国立研究開発法人国立がん研究センター, 研究所, 分野長
Affiliation (based on the past Project Information) *help	2015 – 2020: 国立研究開発法人国立がん研究センター, 研究所, 分野長 2016: 国立研究開発法人国立がん研究センター, その他部局等, その他 2015: 国立研究開発法人国立がん研究センター, 研究所及び東病院臨床開発センター, 分野長 2014: 独立行政法人国立がん研究センター, 研究所, 分野長 2013: 国立がん研究センター研究所, 室長 … More
Review Section/Research Field	Principal Investigator Biological Sciences / Pathological medical chemistry / General medical chemistry / Tumor biology / Complex systems Except Principal Investigator General internal medicine (including Psychosomatic medicine) / Tumor biology / Basic Section 50010:Tumor biology-related / Broad Section I
Keywords	Principal Investigator 癌 / p53 / 発癌 / MDM2 / リン酸化 / 分子生物学 / シグナル伝達 / Mdmx / Mdm2 / cancer … More Except Principal Investigator がん幹細胞 / 乳がん / 1細胞 / 遺伝子発現 / 老化 / 老年医学 / 解糖系代謝 / 癌化 / ストレス老化 / 発癌 / Single cell / cancer stem cells / breast cancer, / semaphoring, neuropilin / RNAシークエンス / シングルセル / 幹細胞 / スフェロイド培養 / neuropilin / PDXモデル / ゲノム変異 / １細胞 / PDX / スフェロイド / トリプルネガティブ乳がん / IGF / セマフォリン / ニューロピリン / ストレス応答 / 蛋白質翻訳 / 発がん実験 / 抗腫瘍薬 Less

Anti-cancer therapies aiming for cure through inhibiting tumor-specific responses to environmental fluctuationOngoing
- Principal Investigator
  
  石川冬木
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section I
- Research Institution
  Kyoto University
Integrative analysis of genetical mutations and heterogeneity based on stemness in breast cancer cellsOngoing
- Principal Investigator
  
  後藤典子
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kanazawa University
個体モデルを用いた大規模シングルセル解析によるがん組織の要素還元論的な理解Principal Investigator
- Principal Investigator
  
  岡本康司
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  National Cancer Center Japan
Regulation epithelial stem cells by reactive oxgens species during oncogenic transformationPrincipal Investigator
- Principal Investigator
  
  Okamoto Koji
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  National Cancer Center Japan
Elucidation of breast cancer tissue diversity by integration analysis of minimum unit omics
- Principal Investigator
  
  Gotoh Noriko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kanazawa University
Elucidation of chemoresistance of refracory cancer by single-cell gene expression analysesPrincipal Investigator
- Principal Investigator
  
  Okamoto Koji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  National Cancer Center Japan
がん転移制御因子の同定と解析を通じた臓器特異的な転移機構の解明Principal Investigator
- Principal Investigator
  
  岡本康司
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Cancer Center Japan
Senescence-inducing stress modulates glycolysis and the Warburg effect
- Principal Investigator
  
  KONDOH Hiroshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Kyoto University
Regulation of cancer stem cells by MDMX/MDM2 oncoproteinsPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Koji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  National Center of Neurology and Psychiatry
Regulation of MDMX oncoprotein by genomic stressesPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Koji
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
Mdm2癌遺伝子産物による、p53癌抑制蛋白の制御機構Principal Investigator
- Principal Investigator
  
  岡本康司
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

All 2019 2017 2016 2015 2014 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells.2019
- Author(s)
  Tominaga, K., Ninato, H., Murayama, T., Sasahara, A., Nishimura, T., Kiyokawa, E., Kanauchi, H., Shimizu, S., Sato, A., Nishioka, K., Tsuji, E., Yano, M., Ogawa, T., Ishii, H., Mori, M., Akashi, K., Okamoto, K., Tanabe, M., Tada, K., Tojo, A., Gotoh, N.
- Journal Title
  
  Proc. Natl. Acad. Sci. U. S. A.
  
  Volume: 116 Issue: 2 Pages: 625-630
- DOI
  10.1073/pnas.1806851116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0251, KAKENHI-PROJECT-17H04282, KAKENHI-PROJECT-18H02679, KAKENHI-PROJECT-16J40231, KAKENHI-PROJECT-17K19587, KAKENHI-PROJECT-17K19698, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06279
[Journal Article] Tumor-derived spheroids: Relevance to cancer stem cells and clinical applications2017
- Author(s)
  Ishiguro T, Ohata H, Sato A, Yamawaki K, Enomoto T, Okamoto K.
- Journal Title
  
  Cancer Sci
  
  Volume: 108 Pages: 283-289
- DOI
  10.1111/cas.13155
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01581, KAKENHI-PROJECT-26293073, KAKENHI-PROJECT-15K14390, KAKENHI-PROJECT-17K16878, KAKENHI-PROJECT-17H04336, KAKENHI-PROJECT-16K15436, KAKENHI-PROJECT-15K20132
[Journal Article] 卵巣がん幹細胞の鍵シグナル2017
- Author(s)
  岡本康司
- Journal Title
  
  月刊「細胞」
  
  Volume: 49 Pages: 108-111
- Data Source
  KAKENHI-PROJECT-26293073
[Journal Article] Heterogeneity among Lgr5-positive colon stem cells.2017
- Author(s)
  Shiokawa D and Okamoto K
- Journal Title
  
  Mol. Cell. Oncol.
  
  Volume: 16
- DOI
  10.1080/23723556.2017.1335271
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H01581
[Journal Article] The Induction of Selected Wnt Target Genes by Tcf1 Mediates Generation of Tumorigenic Colon Stem Cells2017
- Author(s)
  Shiokawa D, Sato A, Ohata H, Muto M, Sekine S, Kato M, Shibata T, Nakagama H, Okamoto K.
- Journal Title
  
  Cell Reports
  
  Volume: 19 Pages: 981-994
- DOI
  10.1016/j.celrep.2017.04.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16878, KAKENHI-PUBLICLY-16H01581, KAKENHI-PROJECT-16K15436
[Journal Article] 卵巣がん幹細胞の鍵シグナル2017
- Author(s)
  岡本康司
- Journal Title
  
  月刊「細胞」
  
  Volume: 49 Pages: 108-111
- Data Source
  KAKENHI-PUBLICLY-16H01581
[Journal Article] Sox2-dependent inhibition of p21 is associated with poor prognosis of endometrial cancer2017
- Author(s)
  Yamawaki K, Ishiguro T, Mori Y, Yoshihara K, Suda K, Tamura R, Yamaguchi M, Sekine M, Kashima K, Higuchi M, Fujii M, Okamoto K, Enomoto T
- Journal Title
  
  Cancer Science
  
  Volume: 108 Pages: 632-640
- DOI
  10.1111/cas.13196
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01581, KAKENHI-PROJECT-26293073, KAKENHI-PROJECT-15K14390, KAKENHI-PROJECT-16K15502, KAKENHI-PROJECT-15H04704, KAKENHI-PROJECT-17H04336, KAKENHI-PROJECT-16H06267, KAKENHI-PROJECT-15K09469, KAKENHI-PROJECT-15K10707, KAKENHI-PROJECT-15K20132
[Journal Article] 卵巣がん幹細胞の鍵シグナル2017
- Author(s)
  岡本康司
- Journal Title
  
  月刊「細胞」
  
  Volume: 49 Pages: 108-111
- Data Source
  KAKENHI-PROJECT-15K14390
[Journal Article] Establishment and Characterization of an In Vitro Model of Ovarian Cancer Stem-like Cells with an Enhanced Proliferative Capacity.2016
- Author(s)
  Ishiguro T, Sato A, Ohata H, Ikarashi Y, Takahashi R, Ochiya T, Yoshida M, Tsuda H, Onda T, Kato T, Kasamatsu T, Enomoto T, Tanaka K, Nakagama H, Okamoto K.
- Journal Title
  
  Cancer Res.
  
  Volume: 76 Pages: 150-160
- DOI
  10.1158/0008-5472.can-15-0361
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14390, KAKENHI-PROJECT-26870877, KAKENHI-PROJECT-25293338, KAKENHI-PROJECT-26293073, KAKENHI-PROJECT-15K15598
[Journal Article] TNIK Inhibition Abrogates Colorectal Cancer Stemness.2016
- Author(s)
  Masuda M, Uno Y, Ohbayashi N, Ohata H, Mimata A, Kukimoto-Niino M, Moriyama H, Kashimoto S, Inoue T, Goto N, Okamoto K, Shirouzu M, Sawa M, Yamada T.
- Journal Title
  
  Nature Commun.
  
  Volume: - Pages: 12586-12586
- DOI
  10.1038/ncomms12586
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01581, KAKENHI-PROJECT-26293073, KAKENHI-PROJECT-15K14390, KAKENHI-PROJECT-16K14627
[Journal Article] MicroRNA-574-3p, identified by microRNA library-based functional screening, modulates tamoxifen response in breast cancer.2015
- Author(s)
  Ujihira T, Ikeda K, Suzuki T, Yamaga R, Sato W, Horie-Inoue K, Shigekawa T, Osaki A, Saeki T, Okamoto K, Takeda S, Inoue S
- Journal Title
  
  Sci. Rep.
  
  Volume: 5 Pages: 7641-7641
- DOI
  10.1038/srep07641
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23249040, KAKENHI-PROJECT-26293073, KAKENHI-PROJECT-26293223
[Journal Article] Hepatocyte nuclear factor-1β promotes glucose uptake and glycolytic activity in ovarian clear carcinoma.2015
- Author(s)
  T Okamoto, M Mandai, N Matsumura, K Yamaguchi, H Kondoh, Y Amano, T Baba, J Hamanishi, K Abiko, K Kosaka, S K, Murphy, S Mori, I Konishi
- Journal Title
  
  Mol Carcinog.
  
  Volume: - Pages: 1-15
- DOI
  10.1002/mc.22072
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390186, KAKENHI-PROJECT-24791700, KAKENHI-PROJECT-24791701, KAKENHI-PROJECT-25670350, KAKENHI-PROJECT-25670703, KAKENHI-PROJECT-26253080
[Journal Article] MicroRNA library-based functional screening identified androgen-sensitive miR-216a as a player in bicalutamide resistance in prostate cancer.2015
- Author(s)
  Miyazaki T, Ikeda K, Horie-Inoue K, Okamoto K, Inoue S
- Journal Title
  
  J Clin Med.
  
  Volume: 4 Pages: 1853-1865
- DOI
  10.3390/jcm4101853
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14390, KAKENHI-PROJECT-15K15073, KAKENHI-PROJECT-15K15353, KAKENHI-PROJECT-26861292, KAKENHI-PROJECT-26293073
[Journal Article] Senescence-inducing stress promotes proteolysis of glycolytic enzyme phosphoglycerate mutase via ubiquitin ligase Mdm2.2014
- Author(s)
  T Mikawa, T Maruyama, K Okamoto, H Nakagama, ME LLeonart, T Tsusaka, K Hori, I Murakami, T Izumi, A T-Kondo, M Yokode, G Peters, D Beach, & H Kondoh
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 204(5) Pages: 729-45
- DOI
  10.1083/jcb.201306149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390186, KAKENHI-PLANNED-24115004, KAKENHI-PROJECT-25670350
[Journal Article] MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells.2014
- Author(s)
  Sakai H, Sato A, Aihara Y, Ikarashi Y, Midorikawa Y, Nakagama H, Okamoto K.
- Journal Title
  
  Cancer Sci.
  
  Volume: 105 Pages: 425-430
- DOI
  10.1111/cas.12380
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23591972, KAKENHI-PROJECT-26293073
[Journal Article] Short Hairpin RNA Library-Based Functional Screening Identified Ribosomal Protein L31 That Modulates Prostate Cancer Cell Growth via p53 Pathway.2014
- Author(s)
  Maruyama Y, Miyazaki T, Ikeda K, Okumura T, Sato W, Horie-Inoue K, Okamoto K, Takeda S, Inoue S
- Journal Title
  
  PLoS One
  
  Volume: 9 Pages: 828-833
- DOI
  10.1371/journal.pone.0108743
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249040, KAKENHI-PROJECT-26293073
[Journal Article] miR-493 induction during carcinogenesis blocks metastatic settle merit of colon cancer cells in liver2012
- Author(s)
  Okamoto K., et al
- Journal Title
  
  EMBO Journal
  
  Volume: 31 Pages: 1752-1763
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590299
[Journal Article] Induction of the stem-like cell regulator CD44 by Rho kinase inhibition contributes to the maintenance ofcolon cancer-initiating cells2012
- Author(s)
  H. Ohata, T. Ishiguro, Y. Aihara, A. Sato, H. Sakai, S. Sekine, H. Taniguchi, T. Akasu, S. Fujita, H. Nakagama, K. Okamoto
- Journal Title
  
  Cancer Res
  
  Volume: 72 Pages: 5101-5110
- Data Source
  KAKENHI-PROJECT-22590299
[Journal Article] miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver.2012
- Author(s)
  Koji Okamoto
- Journal Title
  
  EMBO J
  
  Volume: 31 Pages: 1752-1763
- DOI
  10.1038/emboj.2012.25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590299, KAKENHI-PROJECT-23300359, KAKENHI-PUBLICLY-23112523
[Journal Article] Differential expression of nanogl and nanogp8 in colon cancer cells2012
- Author(s)
  T. Ishiguro, A. Sato, H. Ohata, H. Sakai, H. Nakagama, K. Okamoto:
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 418 Pages: 199-204
- Data Source
  KAKENHI-PROJECT-22590299
[Journal Article] miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver2012
- Author(s)
  K. Okamoto, T. Ishiguro, Y. Midorikawa, H. Ohata, M. Izumiya, N. Tsuchiya, A. Sato, H. Sakai, H. Nakagama
- Journal Title
  
  EMBO J
  
  Volume: 31 Pages: 1752-1763
- Data Source
  KAKENHI-PROJECT-22590299
[Journal Article] miR-493 induction during carcinogenesis blocks metastatic settlemerit of colon cancer cells in liver2012
- Author(s)
  Okamoto K., et al
- Journal Title
  
  EMBO Journal
  
  Volume: 31 Pages: 1752-1763
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23112523
[Journal Article] Tumor-suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p212011
- Author(s)
  N. Tsuchiya, M. Izumiya, H. Ogata-Kawata, K. Okamoto, Y. Fu j iwara, M. Nakai, A. Okabe, A. J. Schetter, E. D. Bowman, Y. Midorikawa, Y. Sugiyama, H. Aburatani, C. C. Harris, H. Nakagama
- Journal Title
  
  Cancer Res
  
  Volume: 71 Pages: 4628-4639
- Data Source
  KAKENHI-PROJECT-22590299
[Journal Article] Systematic exploration of cancer-associated microRNA through functional screening assays2011
- Author(s)
  M. Izumiya, N. Tsuchiya, K. Okamoto, H. Nakagama
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Pages: 1615-21
- NAID
  10030242740
- Data Source
  KAKENHI-PROJECT-22590299
[Journal Article] Cytoplasmic Tethering is involved in Synergistic Inhibition of p53 by Mdmx and Mdm2.2009
- Author(s)
  C. Ohtsubo, D. Shiokawa, M. Kodama, C. Gaiddon, H. Nakagama, A. G. Jochemsen, Y. Taya, and K. Okamoto
- Journal Title
  
  Cancer Science
  
  Pages: 0-0
- NAID
  10027192333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590295
[Journal Article] Frequent inactivation of A20 in B-cell lymphomas.2009
- Author(s)
  M. Kato (the names of 21 authors omitted) K. Okamoto, K. Tobinai, H. Nakagama, T. Nakahata, T. Yoshino, Y. Kobayashi, and S. Ogawa
- Journal Title
  
  Nature in press
  
  Pages: 0-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590295
[Journal Article] Lysine-independent turnover of cyclin G1 can be stabilized by B'alpha subunits of protein phosphatase 2A.2009
- Author(s)
  H. Li, K. Okamoto, M. J. Peart, and C. Prives
- Journal Title
  
  Mol. Cell Biol. 29
  
  Pages: 919-928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590295
[Journal Article] Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2.2008
- Author(s)
  Y. Abe, E. Oda-Sato, K. Tobiume, K. Kawaguchi, Y. Taya, K. Okamoto, M. Oren, and N. Tanaka
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 105
  
  Pages: 4838-4843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590295
[Journal Article] Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis.2007
- Author(s)
  S. Benosman, I. Gross, N. Clarke, A. G. Jochemsen, K. Okamoto, J. P. Loeffler, and C. Gaiddon
- Journal Title
  
  Cell Death & Differentiation 14
  
  Pages: 2047-2057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590295
[Presentation] 大腸がん幹細胞性の進展メカニズム2017
- Author(s)
  岡本康司
- Organizer
  第48回高松宮妃癌研究基金国際シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01581
[Presentation] シングルセル発現解析による大腸がん組織多様性の理解2017
- Author(s)
  岡本康司
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01581
[Presentation] スフェロイド形成による難治がん由来がん幹細胞の培養と特性解析2016
- Author(s)
  岡本康司
- Organizer
  第39 回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-15K14390
[Presentation] スフェロイド形成による難治がん由来がん幹細胞の培養と特性解析2016
- Author(s)
  岡本康司
- Organizer
  第39 回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-26293073
[Presentation] スフェロイド形成による難治がん由来がん幹細胞の培養と特性解析2016
- Author(s)
  岡本康司
- Organizer
  第39 回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01581
[Presentation] 単一細胞レベルの遺伝子発現解析による大腸がんの造腫瘍性細胞及び治療抵抗性細胞の同定2015
- Author(s)
  岡本康司
- Organizer
  第３８回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-15K14390
[Presentation] 単一細胞レベルの遺伝子発現解析による大腸がんの造腫瘍性細胞及び治療抵抗性細胞の同定2015
- Author(s)
  岡本康司
- Organizer
  第３８回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-26293073
[Presentation] 単一細胞レベルの遺伝子発現解析により示されたLgr5 陽性大腸がん幹細胞の多様性2015
- Author(s)
  塩川大介、大畑広和、岡本康司
- Organizer
  第７４回日本癌学会年会
- Place of Presentation
  横浜パシフィコ
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26293073
[Presentation] ヒト大腸がん幹細胞の転移能制御機構の解析2015
- Author(s)
  岡本康司
- Organizer
  第３回がんと代謝研究会
- Place of Presentation
  石川県立音楽堂交流ホール
- Year and Date
  2015-07-16
- Invited
- Data Source
  KAKENHI-PROJECT-26293073
[Presentation] ヒト大腸がん幹細胞の転移能制御機構の解析2015
- Author(s)
  岡本康司
- Organizer
  第３回がんと代謝研究会
- Place of Presentation
  石川県立音楽堂交流ホール
- Year and Date
  2015-07-16
- Invited
- Data Source
  KAKENHI-PROJECT-15K14390
[Presentation] 単一細胞レベルの遺伝子発現解析により示されたLgr5 陽性大腸がん幹細胞の多様性2015
- Author(s)
  塩川大介、大畑広和、岡本康司
- Organizer
  第７４回日本癌学会年会
- Place of Presentation
  横浜パシフィコ
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K14390
[Presentation] miR-493による大腸がん転移の抑制機構2012
- Author(s)
  岡本　康司
- Organizer
  第２１回日本がん転移学会学術集会総会
- Place of Presentation
  広島市
- Year and Date
  2012-07-12
- Data Source
  KAKENHI-PUBLICLY-23112523
[Presentation] miR-493による大腸がん転移の抑制機構2012
- Author(s)
  岡本康司
- Organizer
  第21回日本がん転移学会学術集会総会
- Place of Presentation
  広島市
- Data Source
  KAKENHI-PROJECT-22590299
[Presentation] マウスモデルにおける蛍光イメージングを用いた大腸がん転移制御因子の機能スクリーニング系の確立2012
- Author(s)
  岡本康司
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-22590299
[Presentation] マウスモデルにおける蛍光イメージングを用いた大腸がん転移制御因子の機能スクリーニング系の確立2012
- Author(s)
  岡本　康司
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌市
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PUBLICLY-23112523
[Presentation] 機能的スクリーニングによる大腸がん肝転移制御因子の同定2012
- Author(s)
  岡本　康司
- Organizer
  第３５回日本分子生物学会年会
- Place of Presentation
  福岡市
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PUBLICLY-23112523
[Presentation] 機能的スクリーニングによる大腸がん肝転移制御因子の同定2012
- Author(s)
  岡本　康司
- Organizer
  第３５回日本分子生物学会年会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-22590299
[Presentation] miR-493による大腸がん転移の抑制機構2012
- Author(s)
  岡本　康司
- Organizer
  第２１回日本がん転移学会学術集会総会
- Place of Presentation
  広島市
- Data Source
  KAKENHI-PROJECT-22590299
[Presentation] 機能的スクリーニングによる大腸がん肝転移制御因子の同定2012
- Author(s)
  岡本康司
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-22590299
[Presentation] 大腸がん転移を抑制する新規マイクロRNAの同定及び解析2011
- Author(s)
  岡本康司
- Organizer
  第26回発癌病理研究会
- Place of Presentation
  ルネッサンスサッポロホテル(札幌市)
- Year and Date
  2011-08-30
- Data Source
  KAKENHI-PUBLICLY-23112523
[Presentation] 大腸がん転移の抑制に働くマイクロRNA及びshRNAの機能的スクリーニング2011
- Author(s)
  岡本康司
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(名古屋市)
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PUBLICLY-23112523
[Presentation] 大腸がん転移の抑制に働くマイクロRNA及びshRNAの機能的スクリーニング2011
- Author(s)
  岡本康司
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(名古屋市)
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-22590299
[Presentation] 大腸がん転移を抑制する新規マイクロRNAの同定及び解析2011
- Author(s)
  岡本康司
- Organizer
  第26回発癌病理研究会
- Place of Presentation
  ルネッサンスサッポロホテル(札幌市)
- Year and Date
  2011-08-30
- Data Source
  KAKENHI-PROJECT-22590299
[Presentation] 大腸がん転移を抑制する新規因子の同定及び解析2010
- Author(s)
  岡本康司
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22590299
[Presentation] 大腸がん転移の抑制に働くマイクロRNA及びshRNAの機能的スクリーニング2010
- Author(s)
  岡本康司
- Organizer
  第19回日本がん転移学会学術集会総会
- Place of Presentation
  金沢ニューグランドホテル(金沢市、石川県)
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-22590299
[Presentation] 細胞腫において、Mdmx及びMdm2癌遺伝子産物は協調してp53を細胞束する事により、その活性を抑制する2008
- Author(s)
  岡本康司
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸市(神戸ポートアイランド)
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-19590295
[Presentation] 神経芽細胞腫において、Mdmx及びMdm2癌遺伝子産物は協調してp53を細胞質に拘束する事により、その活性を抑制する2008
- Author(s)
  岡本康司、中釜斉、田矢洋一
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋市(名古屋国際会議場)
- Data Source
  KAKENHI-PROJECT-19590295
[Presentation] BHBN誘発マウス浸潤性膀胱がんにおけるゲノムDNAコピー数の変化2008
- Author(s)
  金本一洋、岡本康司、福田博政、落合正子、杉村隆、中釜斉
- Organizer
  第23回発癌病理学会
- Place of Presentation
  三重・鳥羽市(鳥羽国際ホテル)
- Data Source
  KAKENHI-PROJECT-19590295
[Presentation] 神経芽細胞腫において、Mdmx及びMdm2癌遺伝子産物は協調してp53を細胞質に拘束する事により、その活性を抑制する2008
- Author(s)
  岡本康司、中釜斉、田矢洋一
- Organizer
  第31回日本分子生物学会年会、第31回日本生化学会大会合同大会
- Place of Presentation
  神戸市(神戸ポートアイランド)
- Data Source
  KAKENHI-PROJECT-19590295
[Presentation] 神経芽細胞腫において、Mdmx及びMdm2癌遺伝子産物は協調してp53を細胞質に拘束する事により、その活性を抑制する2008
- Author(s)
  岡本康司
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋市(名古屋国際会議場)
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19590295
[Presentation] Mdmx癌遺伝子はMdm2ユビキチンリガーゼの活性化を介してp53を抑制する2007
- Author(s)
  大坪千裕、田矢洋一、岡本康司
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜市(バシフィコ横浜)
- Data Source
  KAKENHI-PROJECT-19590295
[Presentation] Mdmx stimulates Mdm2-dependent ubiquitination and nuclear export of p532007
- Author(s)
  岡本康司、田矢洋一
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜市(バシフィコ横浜)
- Data Source
  KAKENHI-PROJECT-19590295
[Presentation] Mdmx/Mdm2癌遺伝子産物によるユビキチン化制御機構の破綻とその病理学的役割2007
- Author(s)
  岡本康司、大坪千裕、Christian Gaiddon、田矢洋一
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会ワークショップ"シヌクレイノパチーと癌の統合的戦略"
- Place of Presentation
  横浜市(バシフィコ横浜)
- Data Source
  KAKENHI-PROJECT-19590295
[Presentation] NADPH oxidaseの産生するROSはがん幹細胞の維持に広範な役割を果たす
- Author(s)
  岡本康司
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26293073
[Presentation] 肝転移巣由来の大腸がん幹細胞に特徴的な代謝プロファイルの検索
- Author(s)
  岡本康司
- Organizer
  第22 回がん代謝研究会
- Place of Presentation
  東京理科大学葛飾キャンパス講堂
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-26293073
[Presentation] 単一細胞レベルの発現解析による難治性固形がんの発がんメカニズムの解析
- Author(s)
  岡本康司
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Invited
- Data Source
  KAKENHI-PROJECT-26293073

1. Gotoh Noriko (10251448)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. 東條有伸 (00211681)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 島村徹平 (00623943)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KONDOH Hiroshi (80402890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. YOKODE Masayuki (20252447)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. SOGA Tomoyoshi (60338217)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TAKAORI Akifumi (20324626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. TANAKA Tomoaki (50447299)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NAKAGAMA Hitoshi (30198030)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. KATO Mamoru (40391916)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 鈴木穣 (40323646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 多田敬一郎 (80271568)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 石川冬木 (30184493)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 若林雄一 (40303119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HIDESHI Ishii

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. MORI masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. HAMANISHI Jyunzo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. MATSUMURA Noriomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. BABA Tsukasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. MASUDA Mari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. Hara Toshifumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. Higuchi Masaya

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
23. YOSHIHARA Kousuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. MIDORIKAWA Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 高橋陵宇

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 榎本隆之

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
27. 仲哲治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 石黒竜也

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
29. 大畑広和

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
30. 井上聰

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
31. 堀江公仁子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
32. 山口建

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 万代昌紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 岡本愛光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 小西郁生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 森誠一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 安彦郁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 池田和博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 宮崎利明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 藤井雅寛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 関根正幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 山口雅幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OKAMOTO Koji 岡本 康司

岡本 康司 オカモト コウジ

Research Projects

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Co-Researchers

Anti-cancer therapies aiming for cure through inhibiting tumor-specific responses to environmental fluctuationOngoing

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Integrative analysis of genetical mutations and heterogeneity based on stemness in breast cancer cellsOngoing

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個体モデルを用いた大規模シングルセル解析によるがん組織の要素還元論的な理解Principal Investigator

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Regulation epithelial stem cells by reactive oxgens species during oncogenic transformationPrincipal Investigator

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Elucidation of breast cancer tissue diversity by integration analysis of minimum unit omics

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Elucidation of chemoresistance of refracory cancer by single-cell gene expression analysesPrincipal Investigator

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がん転移制御因子の同定と解析を通じた臓器特異的な転移機構の解明Principal Investigator

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Senescence-inducing stress modulates glycolysis and the Warburg effect

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Regulation of cancer stem cells by MDMX/MDM2 oncoproteinsPrincipal Investigator

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Regulation of MDMX oncoprotein by genomic stressesPrincipal Investigator

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Mdm2癌遺伝子産物による、p53癌抑制蛋白の制御機構Principal Investigator

Principal Investigator

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[Journal Article] Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells.2019

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[Journal Article] Tumor-derived spheroids: Relevance to cancer stem cells and clinical applications2017

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OKAMOTO Koji 岡本康司

岡本康司オカモトコウジ