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NAGAO Taku
長尾 拓
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Alternative Names
長尾 択 ナガオ タク
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Researcher Number
30217971
External Links
Affiliation (based on the past Project Information)
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2001 – 2003: 国立医薬品食品衛生研究所, 副所長
2002: National Institute of Health Sciences, Director General, 所長, 所長
2001: 国立医薬品食品研究所, 副所長(研究職)
1997 – 2000: The University of Tokyo, Graduate School of Pharmaceutical Sciences, Laboratory of Pharmacology and Toxicology, Professor, 大学院・薬学系研究科, 教授
1999: 東京大学, 大学院・薬学研究科, 教授
1995 – 1996: 東京大学, 薬学部, 教授
1990 – 1993: 東京大学, 薬学部, 教授
Review Section/Research Field
Principal Investigator
Biological pharmacy
/
医薬分子機能学
Except Principal Investigator
Biological pharmacy
/
応用薬理学・医療系薬学
/
General pharmacology
Keywords
Principal Investigator
受容体キナーゼ / βアドレナリン受容体 / インターナリゼーション / 2-ハイブリッド法 / カルシウムチャネル / 心筋 / 心不全 / 興奮収縮連関 / 心肥大 / L-type Ca^<2+> channel
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More
/ JNK / ERK / 内皮由来血管弛緩因子 / 一酸化窒素 / カルシウムイオン / バリウムイオン / 冠動脈 / カルモジュリン / 細胞死 / アポトーシス / ネクローシス / トキシコロジー / 重点領域研究 / 生物発光 / GFP / βアレスチン / Cl^-チャネル / HEK293細胞 / タンパク質-タンパク質相互作用 / 蛍光共鳴エネルギー転移 / 細胞内局在 / CLCP Cl^-チャネル / Green Fluorescent Protein(GFP) / Green Fluerescent Protein(GFP) / Blue Fluerescent Protein(BFP) / β受容体サブタイプ / β_1完全活性薬 / Tー0509 / 環状AMPコンパ-トメント / Aキナ-ゼ / L型Ca^<2+>チャンネル / 耐性 / 冠血管拡張作用 / β受容体 / イソプロテレノ-ル / β_1選択性 / 環状AMP / Ca^<2+>電流 / コンパ-トメント / 心収縮 / 心拍数 / beta-adrenoceptor subtypes / beta_1 full agonist / T-0509 / Cyclic AMP compartment / A Kinase / tolerance / L-type CA^<2+> channel / coronary vasodilation / カルシウム拮抗薬 / カルシウム電流 / ジルチアゼム / ニフェジピン / ベラパミル / 高血圧 / 虚血 / パッチクランプ / 高血圧自然発症ラット / 大動脈 / Ca^<2+>antagonist / Ca^<2+>channel / Ca^<2+> current / diltiazem / nifedipine / verapamil / hypertension / ischemia / 細胞内免疫 / モノクローナル抗体 / 一本鎖抗体 / Gタンパク質共役型受容体キナーゼ / サブタイプ特異性 / アデノウイルス / 脱感作 / Gタンパク質共役型受容体 / 抗体分子の遺伝子 / 細胞特異性 / 細胞内発現 / 調節機構 / モノクロール抗体 / 抗体遺伝子 / intracellular immunization / monoclonal antibody / single chain Fv molecule / G protein-coupled receptor kinase / subtype specificily / adonovirus / desensitization / G protein-coupled receptors / Ca^<2+>トランジェント / L型Ca^<2+>チャネル / Ca^<2+>ハンドリング / 心筋梗塞モデル / 梗塞モデル / カルシウム シグナリング / カルシウム チャネル / 細胞骨格 / 洞房結節 / カルシウム トランジェント / 過分極活性型(If)チャネル / Heart failure / Excitation-contraction coupling / Cardiac muscle / Ca^<2+> transients / Ca^<2+> handling / β adrenergic receptors / Myocardial infarction model / カテコラミン / L型カルシウムチャネル / エンドセリン / p38MAPK / 細胞内シグナル伝達 / β-adrenergic receptor / catecholamine / endothelin / heart failure / 活性酸素 / 酸化ストレス / Gタンパク質 / 7回膜貫通型受容体 / Ca^<2+>シグナル / Ca^<2+>チャネル / 心筋細胞 / G-タンパク質 / システイン / カルシウムシグナリング / リアノジン受容体 / reactive oxygen species / oxidative stress / G protein / seven transmembrane / Ca^<2+> signaling / C^<2+> channel / cardiac myocyte / cardiac hypertrophy
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More
Except Principal Investigator
細胞骨格 / parchorin / ウサギ / 胃酸分泌 / リン酸化 / H,K-ATPase / 壁細胞 / エズリン / 小分子GTP結合蛋白質 / gastric secretion / rabbit / phosphatidylinositol transfer protein / CLICファミリー蛋白質 / CLIC family protein / 受容体キナーゼ / α_2アドレナリン受容体 / アンチセンスDNA / モノクロナール抗体 / オメプラゾール / 毛様体上皮細胞 / 胃粘膜 / 眼房水 / モノクローナル抗体 / 視覚障害 / 酸分泌 / αトキシン / 小胞輸送 / アクチン / フォドリン / Gastric Acid Secretion / Ezrin / Cytoskeleton / Phosphorylation / Small GTP-binding protein / ミオシン軽鎖キナーゼ / カルモジュリン / 酵素阻害薬 / myosin light chain kinase / calmodulin / enzyme inhibitor / cytoskeleton / 胃底腺 / βエシン / ジギトニン / プロテインキナーゼ / gastric gland / β-escin / digitonin / 活性酸素 / 酸化ストレス / システイン / Gタンパク質 / シグナリング分子 / 細胞内メディエーター / 酸素毒性 / 細胞保護 / セリン変異体 / reactive oxygen species / oxidative stress / cysteine residue / G protein / signaling molecule / intracellular mediator / 水分輸送 / MDCK細胞 / カゼインキナーゼII / 導管 / プリン作動性 / カゼインキナーゼ / Xenopus Oocytes / water movement / MDCK cells / casein kinase II / duct / purinergic / ノックアウトマウス / knockout mouse
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Research Projects
(
20
results)
Co-Researchers
(
12
People)
Project Start Year (Newest)
Project Start Year (Oldest)
Novel Therapeutic Strategy for Heart Failure : Molecular Mechanism underlying the Regulation of Ca^<2+> Signaling in the Heart
Principal Investigator
Principal Investigator
NAGAO Taku
Project Period (FY)
2001 – 2002
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
Biological pharmacy
Research Institution
National Institute of Health Sciences
Redox Regulation of Signal Transduction Mechanism in the Heart
Principal Investigator
KUROSE Hitoshi
Project Period (FY)
2001 – 2002
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Biological pharmacy
Research Institution
Kyushu University
The University of Tokyo
Analysis of the physiological function of a newly discovered protein, parchorin, specifically expressed in water-secreting cells
Principal Investigator
URUSHIDANI Tetsuro
Project Period (FY)
2001 – 2002
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
応用薬理学・医療系薬学
Research Institution
The University of Tokyo.
Development of a disease model targeting on a newly discovered protein, parchorin, specifically expressed in water-secreting cells
Principal Investigator
URUSHIDANI Tetsuro
Project Period (FY)
2001 – 2003
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
応用薬理学・医療系薬学
Research Institution
National Institute of Health Sciences
The University of Tokyo
Role of receptor kinase in β1-adrenergic receptor signaling, and hypertrophy/heart failure
Principal Investigator
Principal Investigator
NAGAO Taku
Project Period (FY)
1999 – 2000
Research Category
Grant-in-Aid for Scientific Research (B).
Research Field
医薬分子機能学
Research Institution
University of Tokyo
Regulation of the intracellular sorting of gastric proton pump in the parietal cell - Analysis using permeabilized cells.
Principal Investigator
URUSHIDANI Tetsuro
Project Period (FY)
1999 – 2000
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Biological pharmacy
Research Institution
Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Study on regulatory mechanism for cardiac contraction : seeking for therapeutic basis of heart failure.
Principal Investigator
Principal Investigator
NAGAO Taku
Project Period (FY)
1998 – 2000
Research Category
Grant-in-Aid for Scientific Research (A).
Research Field
Biological pharmacy
Research Institution
University of Tokyo
Development of myosin light chain kinase-inhibitors for anti-secretory and anti-ulcer drugs.
Principal Investigator
URUSHIDANI Tetsuro
Project Period (FY)
1998 – 1999
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Biological pharmacy
Research Institution
The University of Tokyo
βアドレナリン受容体の機能の解析とその制御メカニズム
Principal Investigator
Principal Investigator
長尾 拓
Project Period (FY)
1997
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
蛍光共鳴エネルギー転移FRETを用いた2つのタンパク質の相互作用の測定
Principal Investigator
Principal Investigator
長尾 拓
Project Period (FY)
1997 – 1998
Research Category
Grant-in-Aid for Exploratory Research
Research Field
Biological pharmacy
Research Institution
The University of Tokyo
STUDIES IN THE ROLE OF EZRIN IN THE CYTOSKELETAL SYSTEM IN THE PARIETAL CELL
Principal Investigator
URUSHIDANI Tetsuro
Project Period (FY)
1997 – 1998
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Biological pharmacy
Research Institution
THE UNIVERSITY OF TOKYO
酸分泌細胞内小胞輸送における細胞骨格の役割の解明
Principal Investigator
漆谷 徹郎
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
General pharmacology
Research Institution
The University of Tokyo
生物発光を利用した受容体インターナリゼーションの解析
Principal Investigator
Principal Investigator
長尾 拓
Project Period (FY)
1996
Research Category
Grant-in-Aid for Exploratory Research
Research Field
Biological pharmacy
Research Institution
The University of Tokyo
化学物質による細胞障害の機構
Principal Investigator
Principal Investigator
長尾 択
Project Period (FY)
1995
Research Category
Grant-in-Aid for Co-operative Research (B)
Research Field
Biological pharmacy
Research Institution
The University of Tokyo
α_2-アドレナリン受容体の調節機構
Principal Investigator
KUROSE Hitoshi
Project Period (FY)
1995
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Biological pharmacy
Research Institution
The University of Tokyo
プロトンポンプ阻害薬の視覚障害惹起可能性の検証
Principal Investigator
URUSHIDANI Tetsuro
Project Period (FY)
1995
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
応用薬理学・医療系薬学
Research Institution
The University of Tokyo
Establishment of Functional Analysis by Expressing Antibody Molecule in the Cells
Principal Investigator
Principal Investigator
NAGAO Taku
Project Period (FY)
1995 – 1997
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Biological pharmacy
Research Institution
The University of Tokyo (Granduate School of Pharm.Sci.)
イヌの冠動脈における一酸化窒素合成酵素についての研究
Principal Investigator
Principal Investigator
長尾 拓
Project Period (FY)
1992
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
Analysis of effects of Ca-antagonists in pathophysiological models
Principal Investigator
Principal Investigator
NAGAO Taku
Project Period (FY)
1992 – 1993
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Biological pharmacy
Research Institution
University of Tokyo
Regulation by beta-adrenoceptor subtypes of cardiac function : Analysis by selective beta agonists
Principal Investigator
Principal Investigator
NAGAO Taku
Project Period (FY)
1990 – 1991
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Biological pharmacy
Research Institution
University of Tokyo
# of Projects (Dsc)
# of Projects (Asc)
1.
KUROSE Hitoshi
(10183039)
# of Collaborated Projects:
8 results
# of Collaborated Products:
0 results
2.
URUSHIDANI Tetsuro
(40262159)
# of Collaborated Projects:
7 results
# of Collaborated Products:
0 results
3.
AKAHANE Satomi
(00184185)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
4.
ONO Hedeki
(00080200)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
5.
KAWANISHI Toru
(40124383)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
6.
山崎 純
(50230397)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
7.
篠崎 温彦
(20109945)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
8.
高橋 道人
(30080005)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
9.
菅野 盛夫
(00109422)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
10.
井村 伸正
(70012606)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
11.
土井 邦雄
(70155612)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
12.
NOMATA Yasuyuki
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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