UEHARA Yoshihiko 上原芳彦

… Alternative Names

上原芳彦ウエハラヨシヒコ

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Researcher Number	30223499
Affiliation (based on the past Project Information) *help	2016: 東北大学, 医学系研究科, 助教 2012 – 2015: 東北大学, 医学(系)研究科(研究院), 助教 2012: 東北大学, 大学院・医学研究科, 教授 2010 – 2011: 東北大学, 大学院・医学研究科, 助教 2009 – 2011: Tohoku University, 大学院・医学系研究科, 助教 … More 2007: 東北大学, 大学院・医学系研究科, 助教 2001 – 2005: 東北大学, 大学院・医学系研究科, 助手 1993: 関西医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Risk sciences of radiation/Chemicals / Molecular biology Except Principal Investigator Risk sciences of radiation/Chemicals / Radiation science / Clinical oncology
Keywords	Principal Investigator DNA修復 / 突然変異 / 放射線 / Catecholamine / Mutation / Embryonic lethality / Knockout mouse / DNA repair / Thymine DNA Glycosylase(TDG) / カテコールアミン … More / 胎生致死 / ノックアウトマウス / チミンDNAグリコシラーゼ(TDG) / 遺伝子発現 / 概日リズム / 被曝時年令依存性 / 発がん / 被曝時年齢依存性 / マウス / Scatter Factor / ジーンターゲティング / 肝細胞増殖因子 … More Except Principal Investigator lacZ / 放射線 / 突然変異 / NSAIDs / ICM-1 / 非ステロイド性抗炎症薬 / 血管内皮細胞 / mouse / biological significance / mutation / mismatch repair / 染色体 / マウス / 生物学的意義 / ミスマッチ修復 / 放射線防護作用 / 抗がん剤 / 浸潤抑制 / 血管新生阻害 / ミエローマ / がん治療 / マルチターゲット / 発がん予防活性 / 転移抑制活性 / 腫瘍血管阻害活性 / 誘導体 / がん幹細胞 / NF-κBシグナル伝達阻害 / 抗腫瘍活性 / クルクミン / 癌 / ゲノム / マイクロアレイ / 発現制御 / 染色体異常 / カロリー制限 Less

NSAIDs diclofenac, indomethacin, and meloxicam highly upregulate expression of ICAM-1 and COX-2 induced by X-irradiation in human endothelial cells
- Principal Investigator
  
  Hosoi Yoshio
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
Expression analysis of circadian genes in mouse liver exposed to ionizing radiationPrincipal Investigator
- Principal Investigator
  
  Uehara Yoshihiko
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Tohoku University
Development of a new cancer chemotherapy by using curcumin analogs
- Principal Investigator
  
  SHIBATA Hiroyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Akita University
Studies on age-dependency of radiation-induced mutation and its mechanismPrincipal Investigator
- Principal Investigator
  
  UEHARA Yoshihiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Tohoku University
Molecular mechanisms for a suppressive effect of calorie restriction on cancer induction by radiation
- Principal Investigator
  
  ONO Tetsuya
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Tohoku University
Analysis of biological significance of elevated mutation
- Principal Investigator
  
  ONO Tetsuya
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Tohoku University
The Effect of Mismatch-Specific Thymine DNA Glycosylase (TDG) Deficiency on Spontaneous Mutation in MicePrincipal Investigator
- Principal Investigator
  
  UEHARA Yoshihiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Tohoku University
ジーンターゲッティング法による肝細胞増殖因子遺伝子機能の個体レベルでの解析Principal Investigator
- Principal Investigator
  
  上原芳彦
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  Kansai Medical University

All 2016 2015 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Book

[Book] 新老年学第3版2010
- Author(s)
  小野哲也, 上原芳彦, 小村潤一郎
- Publisher
  東京大学出版会
- Data Source
  KAKENHI-PROJECT-19201011
[Journal Article] NSAIDs diclofenac, indomethacin, and meloxicam highly upregulate expression of ICAM-1 and COX-2 induced by X-irradiation in human endothelial cells2016
- Author(s)
  Y Uehara, Y Murata, S Shiga, Y Hosoi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 479 Issue: 4 Pages: 847-852
- DOI
  10.1016/j.bbrc.2016.09.120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293271, KAKENHI-PROJECT-26670547, KAKENHI-PROJECT-26860974
[Journal Article] Activation of mTORC1 under nutrient starvation conditions increases cellular radiosensitivity in human liver cancer cell lines, HepG2 and HuH6.2015
- Author(s)
  Murata Y, Uehara Y, Hosoi Y
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 468 Pages: 684-690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670547
[Journal Article] Inhibition of β-catenin and STAT3 with curcumin analog suppresses gastric carcinogenesis in vivo: a novel candidate for gastric cancer treatment.2015
- Author(s)
  Uehara Y, Inoue M, Fukuda K, Yamakoshi H, Hosoi Y, Kanda H, Oshima M, Iwabuchi Y, Shibata H
- Journal Title
  
  Gastric Cancer
  
  Volume: 18 Pages: 774-783
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670547
[Journal Article] Inhibition of β-catenin and STAT3 with curcumin analog suppresses gastric carcinogenesis in vivo : a novel candidate for gastric cancer treatment2015
- Author(s)
  Uehara, Y., Inoue, M., Fukuda, K., Yamakoshi, H., Hosoi, Y., Kanda, H., Oshima, M., Iwabuchi, Y., Shibata, H.
- Journal Title
  
  Gastric Cancer
  
  Volume: 18 Issue: 4 Pages: 774-783
- DOI
  10.1007/s10120-014-0434-3
- Description
  in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-24510062
[Journal Article] The curcumin analog GO-Y030 is a novel inhibitor of IKKβ that suppresses NF-κB signaling and induces apoptosis2011
- Author(s)
  Sato, A., Kudo, C., Yamakoshi, H., Uehara, Y., Ohor,i H., Ishioka, C., Iwabuchi, Y. Shibata H.
- Journal Title
  
  Cancer Science
  
  Volume: 102(5) Pages: 1045-1051
- NAID
  10029293736
- Data Source
  KAKENHI-PROJECT-22501041
[Journal Article] The curcumin analog GO-Y030 is a novel inhibitor of IKKB that suppresses NF-KB signaling and induces apoptosis.2011
- Author(s)
  Shibata H, Iwabuchi Y, Uehara Y, Ohori H, et al
- Journal Title
  
  Cancer Science
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501041
[Journal Article] Radiation dose-rate effect on mutation induction in spleen and liver of gpt delta mice2010
- Author(s)
  N. Okudaira, Y. Uehara, T. Ono, 他(16名中2番目, 16番目)
- Journal Title
  
  Radiation Research 173(3)
  
  Pages: 138-147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19201011
[Journal Article] XPC is involved in genome maintenance through multiple pathways in different tissues.2009
- Author(s)
  Y.Uehara
- Journal Title
  
  Mutation Research 670
  
  Pages: 24-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21510053
[Journal Article] XPC is involved in genome maintenance through multiple pathways in different tissues.2009
- Author(s)
  Y.Uehara
- Journal Title
  
  Mutation Research 670
  
  Pages: 24-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19201011
[Journal Article] Absence of Ku70 gene obliterates X-ray-induced lacZ mutagenesis of small deletions in mouse tissues2008
- Author(s)
  Y. Uehara, H. Ikehata, T. Ono, 他(16名中1番目, 16番目)
- Journal Title
  
  Radiation Research 170(2)
  
  Pages: 216-223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19201011
[Presentation] Synergistic effects of nonsteroidal anti-inflammatory drugs (NSAIDs) and ionizing radiation on ICAM-1 expression in HUVECs.2015
- Author(s)
  Uehara, Y., Murata, Y., Hosoi, Y.
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  Kyoto International Conference Center (Kyoto)
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24510062
[Presentation] Effects of nutrient starvation condition on radiosensitivity of cultured cells.2015
- Author(s)
  Yasuhiko Murata, Yoshihiko Uehara, Yoshio Hosoi
- Organizer
  15th International Congress of Radiation Research (ICRR)
- Place of Presentation
  Kyoto International Conference Center, Kyoto
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670547
[Presentation] Synergistic effect of nonsteroidal anti-inflammatory drugs (NDAIDs) and ionizing radiation on ICAM-1 expression in HUVECs.2015
- Author(s)
  Yoshihiko Uehara, Yasuhiko Murata, Yoshio Hosoi
- Organizer
  15th International Congress of Radiation Research (ICRR)
- Place of Presentation
  Kyoto International Conference Center, Kyoto
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670547
[Presentation] 低線量率長期照射によるマウス肝臓での遺伝子発現変化の経時的解析2013
- Author(s)
  上原芳彦、王冰、中島徹夫、根井充、中村慎吾、田中聡、一戸一晃、田中公夫、松本恒弥、小木曽洋一、小野哲也、細井義夫
- Organizer
  第51回日本放射線腫瘍学会生物部会学術大会
- Place of Presentation
  東北大学艮陵会館
- Data Source
  KAKENHI-PROJECT-24510062
[Presentation] Kinetic analysis of gene expression profiles in mouse liver after long-term low-dose-rate irradiation2012
- Author(s)
  上原芳彦、王冰、中島徹夫、根井充、小野哲也
- Organizer
  日本放射線影響学会第55回大会
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-24510062
[Presentation] 放射線誘発突然変異のエイジ依存性2011
- Author(s)
  小野哲也、上原芳彦、池畑広伸、小村潤一郎
- Organizer
  日本放射線影響学会第54回大会
- Place of Presentation
  神戸市
- Year and Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-21510053
[Presentation] 非ステロイド性抗炎症薬は放射線と相乗的に作用してヒト血管内皮細胞におけるICAM-1の発現を亢進させる
- Author(s)
  上原芳彦、村田泰彦、細井義夫
- Organizer
  日本放射線影響学会
- Place of Presentation
  かごしま県民交流センター、鹿児島市
- Year and Date
  2014-10-02 – 2014-10-04
- Data Source
  KAKENHI-PROJECT-26670547
[Presentation] 非ステロイド性抗炎症薬（NSAIDs）は放射線と相乗的に作用してヒト血管内皮細胞におけるICAM-1の発現を亢進させる
- Author(s)
  上原芳彦、村田泰彦、細井義夫
- Organizer
  日本放射線影響学会第57回大会
- Place of Presentation
  かごしま県民交流センター（鹿児島）
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-24510062

1. ONO Tetsuya (00107509)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
2. NORIMURA Toshiyuki (20039530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. SHIMADA Yoshiya (10201550)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SHIBATA Hiroyuki (50260071)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. IWABUCHI Yoshiharu (20211766)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. OHORI Hisatsugu (30431555)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. IKEHATA Hironobu (90250737)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAKAMURA Nori (00010116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Hosoi Yoshio (50238747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
10. 上原至雅

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 神田浩明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 井上純一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

UEHARA Yoshihiko 上原 芳彦

上原 芳彦 ウエハラ ヨシヒコ

Research Projects

Research Products

Co-Researchers

NSAIDs diclofenac, indomethacin, and meloxicam highly upregulate expression of ICAM-1 and COX-2 induced by X-irradiation in human endothelial cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Expression analysis of circadian genes in mouse liver exposed to ionizing radiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a new cancer chemotherapy by using curcumin analogs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on age-dependency of radiation-induced mutation and its mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms for a suppressive effect of calorie restriction on cancer induction by radiation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of biological significance of elevated mutation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Effect of Mismatch-Specific Thymine DNA Glycosylase (TDG) Deficiency on Spontaneous Mutation in MicePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ジーンターゲッティング法による肝細胞増殖因子遺伝子機能の個体レベルでの解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 新老年学 第3版2010

Author(s)

Publisher

Data Source

[Journal Article] NSAIDs diclofenac, indomethacin, and meloxicam highly upregulate expression of ICAM-1 and COX-2 induced by X-irradiation in human endothelial cells2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of mTORC1 under nutrient starvation conditions increases cellular radiosensitivity in human liver cancer cell lines, HepG2 and HuH6.2015

Author(s)

Journal Title

Data Source

[Journal Article] Inhibition of β-catenin and STAT3 with curcumin analog suppresses gastric carcinogenesis in vivo: a novel candidate for gastric cancer treatment.2015

Author(s)

Journal Title

Data Source

[Journal Article] Inhibition of β-catenin and STAT3 with curcumin analog suppresses gastric carcinogenesis in vivo : a novel candidate for gastric cancer treatment2015

Author(s)

Journal Title

DOI

Description

Data Source

[Journal Article] The curcumin analog GO-Y030 is a novel inhibitor of IKKβ that suppresses NF-κB signaling and induces apoptosis2011

Author(s)

Journal Title

NAID

UEHARA Yoshihiko 上原芳彦

上原芳彦ウエハラヨシヒコ

[Book] 新老年学第3版2010