TOKUTOMI Nofumi 徳冨直史

… Alternative Names

TOKUTOMI Naofumi 徳富直史

Less

Researcher Number	30227582
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2022 – 2023: 崇城大学, 薬学部, 教授 2005: Sojo University, Faculty of pharmaceutical Sciences, Laboratory of Pharmacology, Professor, 薬学部, 教授 2002 – 2004: Kumamoto University, Graduate School of Medicine, Department of Pharmacology, Associate Professor, 大学院・医学薬学研究部, 助教授 1998 – 2002: 熊本大学, 医学部, 助教授 1995 – 1996: 熊本大学, 医学部, 助教授 1992 – 1994: Kumamoto University Asistant Medical School Professor, 医学部, 講師 1990 – 1991: 東北大学, 医学部, 助手
Review Section/Research Field	Principal Investigator General pharmacology / General pharmacology / Neurophysiology and muscle physiology / General physiology Except Principal Investigator General pharmacology / 応用薬理学・医療系薬学 / Neurophysiology and muscle physiology / Basic Section 08030:Family and consumer sciences, and culture and living-related / Biological pharmacy
Keywords	Principal Investigator AMPA / パッチクランプ法 / apoptosis / necrosis / electromagnetic stimulation / myelination / Schwann cell / neuron / アポトーシス / ネクローシス … More / 磁気刺激 / 再髄鞘化 / シュワン細胞 / ニューロン / kainate receptor-mediated excitatory postsynaptic currents / cortex / hippocampus / patch-clamp technique / synaptic formation / neurite elongation / anti c-KIT monoclonal antibody (ACK2) / kainate型シナプス活動 / 抗 c-KIT モノクローナル抗体 / 脊髄後根神経節細胞 / kainate型シナプス / 大脳皮質ニューロン / 海馬ニューロン / シナプスの形成 / 神経突起の伸展 / 抗c-KITモノクローナル抗体 / Calmodulin-dependent protein kinase / inositol triphosphate / GTP-binding protein / receptor subtype / muscarinic receptor / hippocampal pyramidal neuron / Cotex neuron / 蛍光トレーサー / 興奮性応答 / 中隔核 / マイナート隔 / イオン電流 / ムスカリン様受容体 / 中枢神経細胞 / アセチルコリン / カルモジュリン依存性プロテインキナーゼ / イノシトール三リン酸 / 細胞内Ca^<2+> / GTP結合蛋白 / 受容体サブタイプ / ムスカリン受容体 / 海馬錐体細胞 / 大脳皮質細胞 / シナプス形成 / シナプス応答 / 中枢神経機能 / C-KITチロシンキナーゼレセプター … More Except Principal Investigator c-kit / caffeine / mouse / smooth muscle / マウス / パッチクランプ法 / GM-CSF / ryanodine / 細胞内Ca^<2+>貯蔵部位 / pacemaker / 平滑筋 / COPD / 肺胞上皮細胞 / グリチルリチン / 慢性閉塞性呼吸器疾患 / 気道粘液 / ETS転写因子 / fura-2 / intracellular Ca^<2+> / Ca^<2+> storage / Ca^<2+>貯蔵部位 / 細胞内Ca^<2+> / ペースメーカー / 胃平滑筋 / Patch-clamp technique / 細胞内カルシウム / アセチルコリン / プロトオンコジーンc-kit / 電気生理学 / ラット / 内臓脂肪 / 食品機能性成分 / ポリフェノール / カロテノイド / 脂肪細胞 / メタボリック症候群 / 肥満 / フラボノイド / 機能性食品成分 / Tanscription factor / Glucocorticoid / Airway Inflammation / Neutrophil elastase / 粘液遺伝子 / 肺上皮細胞 / MUC1ムチン / aquaporin-5 / Sp3転写因子 / 杯細胞 / レチノイン酸 / Sp1転写因子 / 転写因子 / グルココルチコイド / 気道炎症 / 好中球エラスターゼ / 慢性閉塞性肺疾患 / α_1-acid glycoprotein / contraction / ryanodine感受性Ca^<2+>放出 / 等尺性張力 / α_1酸性糖蛋白質 / 収縮 / patch-clamp technique / Ca^<2+> / autonomic motility / Kit / ペースメーカー細胞 / 自動運動能 / c-Kit / epithelial cells / lung / pulmonary surfactant / airway mucin / ETS transcription factor / 漢方薬 / ETS-2 / MEF / 細胞分化 / 11β-hydroxysteroid dehydrogenase / prostanlandin E_2 / 気道上皮細胞 / 上皮細胞 / 肺 / 肺サーファクタント / ryanodine感受性Ca^<2+>ストア / 細胞内Ca^<2+>動態 / 平滑筋細胞 / development / TEA感受性Ca^<2+>活性化K^+電流 / カフェイン・カルバコール応答 / 細胞内Ca濃度 / マウス膀胱平滑筋 / Ca^<2+>放出機構 / イノシトール三燐酸受容体 / リアノジン受容体 / c-kit陽性細胞 / 分化 / cultured c-kit (+) cell / GI motility ileum / antibody for kit-protein (ACK2) / c-kit tyrosinekinase / gastrointestinal tract / pacemaker activity / interstitial cell (IC) / ryanodine感受性Ca^<2+>貯蔵部位 / c-kit発現 / 自発性Ca^<2+>-activated K^+電流 / 膀胱平滑筋 / Ca^<2+>-activated K^+電流 / 細胞内Ca^<2+>濃度測定 / 抗c-kitモノクローナル抗体(ACK2) / c-kit発現細胞 / 自動運動のペースメーカー機構 / ACK2に対する蛍光抗体法 / ブラジキニン / 麻痺性イレウス / モノクローナル抗体(ACK2) / Second messenger / Intracellular calcium / Calcium channel / Nystatin / GTP-binding protein / Pharmacological classification / Central neurones / セカンドメッセンジャー / カルシウムチャネル / ニスタチン / GTP結合蛋白 / 薬理学的分類 / 中枢神経細胞 / Quinolone / Non-steroidal anti-inflammatory / gamma-Aminobutyric acid-A response / Rat hippocampal neuron / 4ービフェニル酢酸(BPA) / 痙攣誘発作用 / 非ステロイド系抗炎症剤 / 新キノロン剤 / Acutely dissociated neurons / Rat / Electrophysiology / Fluorescent die / Multifunction simultaneous recording system / cagcd化合物 / caged化合物 / 単離中枢神経細胞 / イオン測定蛍光試薬 / Caged化合物 / 多現象同時計測装置 / 急性単離細胞 / 電気生理 / 蛍光指示薬 / 多現象同時測定装置 / developmental process of intestinal movement / intestinal smooth muscle / protein tyrosinekinase / protooncogene c-kit / gut pacemaker mechanism / inplannted myocardium / ionic channel in excitable membrane / cardiac action potential / Kチャネル / Naチャネル / 発達過程 / カハ-ル細胞 / 心筋ペ-スメ-カ- / 腸管ペ-スメ-カ-機構 / リセプタ-・チロシンキナ-ゼ / Cーkitプロトオンコジ-ン / マウス胎児心筋 / イオンチャネル / プロスタグランジンF_2α / 腸管運動の発達 / 抗c-kit発現チロシンキナーゼ抗体 / カハール細胞 / 腸管ペースメーカー活動 / 腸管平滑節細胞 / 腸管自動能発達過程 / 腸管平滑筋 / 蛋白チロシンキナーゼ / プロトオンコジンc-kit / 腸管ペースメーカー機構 / 移植心筋 / 興奮性膜イオンチャネル / 心筋活動電位 / lidocaine / kinetics / heterogeneous distribution / scorpion toxin / divalent cation permeability / tetrodotoxin-sensitive Ca current / isolated pyramidal neuron / rat hippocampal CA1 region / 単離錐体細胞 / TTX感受性Ca電流 / 海馬CA1領域 / リグノカイン(リドカイン) / キネテイクス / 脳内分布 / スコ-ピオントキシン / 2価陽イオン透過性 / テトロドトキシン感受性カルシウム電流 / 急性単離錐体細胞 / ラット海馬CA1領域 Less

脂肪細胞機能制御因子を標的とした食品機能性成分によるメタボリック症候群予防の検討
- Principal Investigator
  
  徳冨芳子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 08030:Family and consumer sciences, and culture and living-related
- Research Institution
  Kyushu University of Nursing and Social Welfare
Basic study to develop a new therapeutic drug in chronic obstructive pulmonary disease
- Principal Investigator
  
  MIYATA Takeshi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University
An experimental model for axonal regeneration in vitro and its applicationPrincipal Investigator
- Principal Investigator
  
  TOKUTOMI Naofumi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Sojo University
  Kumamoto University
Roles of Kit signalling in smooth muscle tissues
- Principal Investigator
  
  NISHI Katsuhide
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  KUMAMOTO UNIVERSITY
Roles of c-kit in development and pathophysiology of smooth muscle
- Principal Investigator
  
  TOKUTOMI Yoshiko
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kumamoto University
Development of therapeutic ways on various pathological features in chronic obstructive pulmonary diseases
- Principal Investigator
  
  MIYATA Takeshi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kumamoto University
Roles of c-kit in functional development of Ca^<2+> release mechanism in smooth muscle cells
- Principal Investigator
  
  TOKUTOMI Yoshiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  KUMAMOTO UNIVERSITY
Molecular mechanism of development of mammalian smooth mscle
- Principal Investigator
  
  NISHI Katsuhide
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  KUMAMOTO UNIVERSITY
Roles of c-KIT on the development in synaptic function and CaィイD12+ィエD1 signalingPrincipal Investigator
- Principal Investigator
  
  TOKUTOMI Nofumi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kumamoto University
中枢シナプス可塑性におけるc-kitチロシンキナーゼレセプターの役割Principal Investigator
- Principal Investigator
  
  徳冨直史
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kumamoto University
A Role of c-kit tyrosinekinase of physiological development of the gastrointestinal pacemaker activity
- Principal Investigator
  
  NISHI Katsuhide
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  KUMAMOTO UNIVERSITY
Ca^<2+> and signal transduction in CNS neurones.
- Principal Investigator
  
  AKAIKE Norio
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KYUSHU UNIVERSITY
  Tohoku University
Mechanisms of the muscarinic excitability in identified cortical and hippocampal neuronsPrincipal Investigator
- Principal Investigator
  
  TOKUTOMI Naofumi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  KUMAMOTO UNIVERSITY
Novel tetrodotoxin-sensitive Ca^<2+> current in mammalian neurons - function and distribution
- Principal Investigator
  
  AKAIKE Norio
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Tohoku University
Factors influencing differentiation and development of ionic channels in cardiac muscle
- Principal Investigator
  
  NISHI Katsuhide
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  KUMAMOTO UNIVERSITY
DEVELOPMENT OF NEW SYSTEM USED CAGED-COMPOUND BY WHICH THE PHYSIOLOGICAL FUNCTION OF CNS NEURONS CAN BE CLARIFIED.
- Principal Investigator
  
  AKAIKE Norio
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  TOHOKU UNIVERSITY
Interaction of various-non-steroidal anti-inflammatories and quinolone antimicrobials on GABA response in rat dissociated hippocampal pyramidal neurons
- Principal Investigator
  
  NAKAYE Toshio
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tohoku University

All 2006 2005 2004 2003

All Journal Article Patent

[Journal Article] Roles of ryanodine receptor in rate capability of beating ventricular myocytes in culture.2006
- Author(s)
  Tokutomi N
- Journal Title
  
  J.of Pharmacol.Sci. 100
  
  Pages: 75-75
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590232
[Journal Article] Roles of ryanodine receptor in rate capability of beating ventricular myocytes in culture.2006
- Author(s)
  Tokutomi N.
- Journal Title
  
  Journal of Pharmacological Sciences 100
  
  Pages: 75-75
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590232
[Journal Article] c-kit機能欠如マウス消化管平滑筋の薬物に対する異常反応2004
- Author(s)
  徳富直史, 他
- Journal Title
  
  日薬理誌 123・3
  
  Pages: 163-169
- NAID
  10017019128
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590232
[Journal Article] Drug-induced anomalous contraction of gastrointestinal tract of mice with impaired c-kit function.2004
- Author(s)
  Tokutomi N, Tokutomi Y, Nishi K
- Journal Title
  
  Folia Pharmacol Jpn. 123
  
  Pages: 163-169
- NAID
  10017019128
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590232
[Journal Article] Effects of □_1-acid glycoproctein on isometric tension of mouse aorta2003
- Author(s)
  Tokutomi Y., et al.
- Journal Title
  
  Eur.J.Pharmacol 477・2
  
  Pages: 137-141
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590232
[Journal Article] Effects of α_1-acid glycoprotein on blood circulation.2003
- Author(s)
  Matsumoto K, Okamoto S, Tokutomi Y, Tokutomi N, Nishi K, Maruyama T, Suenaga A, Otagiri M
- Journal Title
  
  Artificial Blood 11・2
  
  Pages: 144-150
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590232
[Journal Article] Effects of α_1-acid glycoprotein on isometric tension of mouse aorta.2003
- Author(s)
  Tokutomi Y, Okamoto S, Matsumoto K, Otagiri M, Nishi K, Tokutomi N
- Journal Title
  
  Eur.J.Pharmacol 477・2
  
  Pages: 137-141
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590232
[Journal Article] A distinct distribution of functional presynaptic 5-HT receptor subtypes on GABAergic nerve terminals projecting to single hippocampal CA1 pyramidal neurons.2003
- Author(s)
  Katsurabayashi S, Kubota H, Tokutomi N, Akaike N
- Journal Title
  
  Neuropharmacol 44
  
  Pages: 1022-1030
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590232
[Patent] 病態ならびに生体電気信号発生培養容器2006
- Inventor(s)
  徳冨直史
- Industrial Property Rights Holder
  科学技術振興機構他
- Industrial Property Number
  2006-030870
- Filing Date
  2006-02-08
- Data Source
  KAKENHI-PROJECT-15590232
[Patent] 2.病態ならびに生体電気信号発生培養容器2006
- Inventor(s)
  徳富直史
- Industrial Property Rights Holder
  科学技術振興機構他
- Industrial Property Number
  2006-030870
- Filing Date
  2006
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590232
[Patent] 1.磁場又は電場刺激及びその…促進2005
- Inventor(s)
  徳富直史
- Industrial Property Rights Holder
  科学技術振興機構他
- Filing Date
  2005
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590232

1. TOKUTOMI Yoshiko (90253723)

# of Collaborated Projects: 9 results

# of Collaborated Products: 8 results
2. NISHI Katsuhide (00040220)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
3. AKAIKE Norio (30040182)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. NAKAYE Toshio (20155659)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. NABEKURA Junich (50237583)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. KAWA Kazuyoshi (70125839)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. ISOHAMA Yoichiro (10240920)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. MIYATA Takeshi (90040310)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. KAI Hirofumi (30194658)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. YASUI Shouzo (50132741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. HARATA Nobutoshi (90264043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. FUKUNAGA Kohji (90136721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKAHAMA Kazuo (80150548)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 荒木春夫 (80151158)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 小山保夫 (80214229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KOIDE Ikuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KUDO Yoshihisa

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. YATANI A.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. BROWN A.m.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. BEHRENDS J.c.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 喜納兼勇

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. LUX H.D.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TOKUTOMI Nofumi 徳冨 直史

TOKUTOMI Naofumi 徳富 直史

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

An experimental model for axonal regeneration in vitro and its applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of c-KIT on the development in synaptic function and CaィイD12+ィエD1 signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

中枢シナプス可塑性におけるc-kitチロシンキナーゼレセプターの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Mechanisms of the muscarinic excitability in identified cortical and hippocampal neuronsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

TOKUTOMI Nofumi 徳冨直史

TOKUTOMI Naofumi 徳富直史