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Seko Yoshinori  世古 義規

… Alternative Names

SEKO Yoshinori  世古 義規

世古 義則  セコ ヨシノリ

瀬古 義規

Less
Researcher Number 30240708
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-5734-335X
External Links
Affiliation (Current) 2025: 順天堂大学, 大学院医学研究科, 客員教授
2025: 公益財団法人朝日生命成人病研究所, その他部局等, 教授(移行)
Affiliation (based on the past Project Information) *help 2021 – 2024: 順天堂大学, 大学院医学研究科, 客員教授
2019 – 2021: 順天堂大学, 医学(系)研究科(研究院), 客員教授
2002 – 2004: The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師
1996 – 2001: 東京大学, 医学部・附属病院, 助手
1999: 東京大学, 医学部・付属病院, 助手 … More
1998: 東京大学, 医学部附属病院, 助手
1997: 東京大学, 医学部・付属病院, 助手
1992 – 1995: 東京大学, 医学部(病), 助手
1988: 東京大学, 医学部, 医員 Less
Review Section/Research Field
Principal Investigator
Circulatory organs internal medicine / Basic Section 53020:Cardiology-related / Circulatory organs internal medicine
Except Principal Investigator
Circulatory organs internal medicine / Basic Section 53020:Cardiology-related / Basic Section 55020:Digestive surgery-related
Keywords
Principal Investigator
VEGF / reperfusion / autocrine / reoxygenation / hypoxia / ischemia / 細胞内情報伝達 / apoptosis / cardiac myocytes / 酸化ストレス … More / 心筋細胞 / 血管内皮細胞 / 接着分子 / bioactive substance / T-cell receptor / dilated cardiomyopathy / myocarditis / 心筋虚血再灌流障害 / receptor / oxidative stress / ligand superfamily / TNF receptor / costimulatory molecule / immunotherapy / Takayasu Arteritis / オートクライン / intracellular signal transduction / 虚血再灌流 / レドックス / 細胞内シグナル伝達 / cell-mediated immunity / 老化 / 動脈硬化 / ORAIP / 受容体 / 生理活性因子 / MAPK / アポトーシス / intracellular calcium / cardiac function / myocardial tissue / orphan receptor / G protein / 細胞内カルシウム / 心機能 / オーファン・レセプター / G蛋白質 / 心筋 / auto-antigen / arteritis / dilated cardimyopathy / bioacive substance / cardiac myocyte / humoral 48ctor / signal transduction / redox / reoxyaenation / hypoxia reoxygenation / humoral factor / 虚血再灌流障害 / 虚血・再灌流 / 液性因子 / 低酸素・再酸素化 / anti-cell-adhesion molecule therapy / acute myocardial infarction / angina pectoris / myocardial ischemia / 好中球 / 再灌流障害 / VFGF / 不安定狭心症 / 無症候性心筋虚血 / 虚血再潅流障害 / 抗接着分子療法 / 急性心筋梗塞 / 狭心症 / 心筋虚血再灌流 / 糖鎖 / セレクチン / 細胞内情報伝達系 / 心筋虚血再潅流障害 … More
Except Principal Investigator
BTEB2 / 転写因子 / 平滑筋細胞 / ORAIP / CARP / transplantation / cell-adhesion molecules / 細胞内情報伝達 / MAPキナーゼ / 虚血再灌流 / サイトカイン / Sp1 / 動脈硬化 / 潰瘍性大腸炎 / 酸化ストレス誘導蛋白 / マウス冠動脈炎 / LCWE誘導マウス冠動脈炎 / LCWE / 冠動脈炎 / 川崎病 / バイオマーカー / 抗体医療 / アポトーシス / 肺動脈性肺高血圧症 / 対麻痺 / 胸腹部大動脈瘤治療 / 胸腹部大動脈瘤 / 脊髄障害 / therapy / transcription factor / interstitium / cardiovascular system / DNAチップ / klotho / 活性化 / 心血管系 / 間質細胞 / 治療 / 間質 / 心血管 / Endothelin / Heart Failure / Hypertrophy / Gene / Transcription / Stress / Heart / NFkB / 酸化ストレス / Mn-SOD / 細胞外マトリックス / Smad / TGFβ / プロモーター / アドリアマイシン / p38 / BNP / Rac1 / エンドセリン / 細胞障害 / myocarditis / myocardial infarction / S6 kinase / Rar-1 kinase / MAP kinase / reoxygenation / hypoxia / 心筋虚血再潅流 / CD62(GMP-140) / CD54(ICAM-1) / 抗体治療 / 細胞間接着分子 / 心筋虚血再灌流 / S6 キナーゼ / Romano-Ward 症候群 / Raf-1 キナーゼ / MAP キナーゼ / Cell-adhesion moleculcs / 心臓移植 / 心筋炎 / S6キナーゼ / Raf-1キナーゼ / proto-oncogene / hypertrophy / PI turnover / intracellular signaling / mechanical stress / myocytes / プロテインキナ-ゼC / MAPキナ-ゼ / ラット / 伸展刺激 / プロテインキナーゼC / ゲル内リン酸化 / 心肥大 / 血流ストレス / フォスファチジルイノシトール代謝 / 機械的ストレス / 心筋細胞 / 細胞内シグナル伝達系 / 腎尿細管と血管内皮細胞共通抗原 / インターロイキン6 / インターロイキン1 / モノクローナル抗体 / 拡張型心筋症 / Klotho 遺伝子 / ミオシン軽鎖 / 単一心筋 / 細胞内カルシウム / バルーン傷害 / Cキナーゼ / CREB / Rb / Id Less
  • Research Projects

    (23 results)
  • Research Products

    (15 results)
  • Co-Researchers

    (34 People)
  •  酸化ストレス応答アポトーシス誘導蛋白ORAIPが動脈硬化・老化に果たす役割Principal Investigator

    • Principal Investigator
      世古 義規
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Juntendo University
  •  酸化ストレス応答アポトーシス誘導蛋白のUCに対する新規Biomarker探索と治療への展開

    • Principal Investigator
      渋谷 智義
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Juntendo University
  •  川崎病冠動脈炎における酸化ストレス誘導蛋白(ORAIP)の役割と新規治療薬の開発

    • Principal Investigator
      菅沼 栄介
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Saitama Children's Medical Center
  •  胸腹部大動脈術後脊髄再灌流障害の新たな細胞障害機序の解明と治療法の開発

    • Principal Investigator
      中井 秀和
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Kobe University
  •  Elucidation of the relationship of novel apoptosis-inducing substances to the pathophysiology of pulmonary arterial hypertension

    • Principal Investigator
      EGUCHI Masamichi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Nagasaki University
  •  Identification of the Receptor for ORAIP That Mediates Cardiac Response to Oxidative Stresses and Development of TreatmentPrincipal Investigator

    • Principal Investigator
      SEKO Yoshinori
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  Identification of the ligands for Cardiac Orphan G protein -Coupled Receptors and Development of T herapy Modulating Cardiac FunctionPrincipal Investigator

    • Principal Investigator
      SEKO Yoshinori
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  心血管系の負荷応答と病態形成:遺伝子転写シグナルと病態生理に基づく治療戦略の確立

    • Principal Investigator
      永井 良三
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  拡張型心筋症(慢性心筋炎)のモデル動物の作成と治療法開発への応用Principal Investigator

    • Principal Investigator
      世古 義規
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  Development of inhibitors for the activation of cardiovascular interstitial ceils

    • Principal Investigator
      NAGAI Ryozo
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  Purification and Identification of the Bioactive Subs tance That Mediates Cardiac Response to the Ischemia Reperfusion Stresses and Development of TreatmentPrincipal Investigator

    • Principal Investigator
      SEKO Yoshinori
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      University of Tokyo
  •  Development of the Specific Immunotherapy for Myocarditis, Dilated Cardiomyopathy(Chronic Myocarditis), and Takayasu Arteritis.Principal Investigator

    • Principal Investigator
      SEKO Yoshinori
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      University of Tokyo
  •  血管平滑筋細胞における転写因子Idの機能と発現調節機序

    • Principal Investigator
      KURABAYASHI Masahiko
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Gunma University
  •  Molecular Mechanisms of Genetic Response of Myocardial Cells to Cytotoxic Stress

    • Principal Investigator
      KURABAYASHI Masahiko
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Gunma University
  •  Elucidation of the Molecular Mechanism of Cardiac Response to the Ischemia Reperfusion Stresses and Establishment of Treatment Based on the Molecular MechanismPrincipal Investigator

    • Principal Investigator
      SEKO Yoshinori
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  心筋虚血再灌流障害における細胞内情報伝達機構の解明および抗接着分子療法の確立Principal Investigator

    • Principal Investigator
      世古 義規
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  心筋虚血再灌流障害に対する抗接着分子療法の確立および心筋細胞応答の分子機構の解析Principal Investigator

    • Principal Investigator
      世古 義規
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  Development of Molecular Biologic Diagnostic and Therapeutic Method of Asymptomatic Myocardial Ischemia and Unstable AnginaPrincipal Investigator

    • Principal Investigator
      SEKO Yoshinori
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      University of Tokyo
  •  心筋虚血再灌流障害の細胞内・細胞間分子機構の解明とそれに基づいた予防法の確立Principal Investigator

    • Principal Investigator
      世古 義則
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  心筋虚血再潅流障害の分子機構の解明および接着分子タンパクを用いた予防法の確立Principal Investigator

    • Principal Investigator
      世古 義規
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  The elucidation of the roles of cell-adhesion molecules in heart diseases

    • Principal Investigator
      YAZAKI Yoshio
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      University of Tokyo
  •  Intracellular Signaling of Stretch Mediated Myocyte Growth

    • Principal Investigator
      YAZAKI Yoshio
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  抗心筋細胞膜モノクローナル抗体による拡張型心筋症の病態生理の解析

    • Principal Investigator
      土持 英嗣
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo

All 2020 2004 2003 Other

All Journal Article Patent

  • [Journal Article] Effect of intravenous heparin on serum levels of endostatin, VEGF and HGF : author's reply.2004

    • Author(s)
      Seko Y
    • Journal Title

      Clin Sci 107

      Pages: 424-424

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390240
  • [Journal Article] Serum levels of endostatin, vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in patients with acute myocardial infarction undergoing early reperfusion therapy.2004

    • Author(s)
      Seko Y, Fukuda S, Nagai R
    • Journal Title

      Clin Sci 106

      Pages: 439-442

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390240
  • [Journal Article] Serum levels of endostatin, vascular endothelial growth factor (VEGF), and hepatocyte growth factor (HGF) in patients with acute myocardial infarction undergoing early reperfusion therapy.2004

    • Author(s)
      Seko Y, Fukuda S, Nagai R
    • Journal Title

      Clin Sci 106

      Pages: 439-442

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390240
  • [Journal Article] Hypoxia followed by re oxygenation induces secretion of cyclophilin A (CyPA) from cultured rat cardiac myocytes.2004

    • Author(s)
      Seko Y, Fujimura T, Taka H, et al.
    • Journal Title

      Biochem Biophys Res Commun 317

      Pages: 162-168

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390240
  • [Journal Article] Hypoxia followed by reoxygenation induces secretion of cyclophilin A (CyPA) from cultured rat cardiac myocytes.2004

    • Author(s)
      Seko Y, Fujimura T, Taka H, et al.
    • Journal Title

      Biochem Biophys Res Commun 317

      Pages: 162-168

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390240
  • [Journal Article] Serum levels of endostatin, vascular endothelial growth factor (VEGF), and hepatocyte growth factor (HGF) in patients with acute myocardial infarction undergoing early reperfusion therapy2004

    • Author(s)
      Seko Y, Fukuda S, Nagai R
    • Journal Title

      Clin Sci 106

      Pages: 439-442

    • Data Source
      KAKENHI-PROJECT-15390240
  • [Journal Article] Expression of costimulatory molecules (4-1BBL and Fas) and MHC class I chain-related A (MICA) in aortic tissue with Takayasu's arteritis.2004

    • Author(s)
      Seko Y, Sugishita K, et al.
    • Journal Title

      J Vas Res 41

      Pages: 84-90

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390240
  • [Journal Article] Expression of costimulatory molecules (4-1 BBL and Fas) and MHC class I chain-related A (MICA) in aortic tissue with Takayasu's arteritis.2004

    • Author(s)
      Seko Y, Sugishita K, Sato O, et al.
    • Journal Title

      J Vas Res 41

      Pages: 84-90

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390240
  • [Journal Article] Genetic background influences therapeutic effectiveness of VEGF.2003

    • Author(s)
      Fukino K, Sata M, Seko Y, et al.
    • Journal Title

      Biochem Biophys Res Commun 310

      Pages: 162-168

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390240
  • [Journal Article] Genetic background influences therapeutic effectiveness of VEGF.2003

    • Author(s)
      Fukino K, Sata M, Seko Y, Hirata Y, Nagai R
    • Journal Title

      Biochem Biophys Res Commun 310

      Pages: 143-147

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390240
  • [Journal Article] Takayasu myocarditis mediated by cytotoxic T lymphocytes

    • Author(s)
      Takeda N, Takahashi T, Seko Y, et al.
    • Journal Title

      Internal Med (In press)

    • NAID

      10015567420

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390240
  • [Journal Article] Takayasu myocarditis mediated by cytotoxic T lymphocytes.

    • Author(s)
      Takeda N, Takahashi T, Seko Y, et al.
    • Journal Title

      Internal Med (In press)

    • NAID

      10015567420

    • Data Source
      KAKENHI-PROJECT-15390240
  • [Journal Article] Takayasu myocarditis mediated by cytotoxic T lymphocytes.

    • Author(s)
      Takeda N, Takahashi T, Seko Y, et al.
    • Journal Title

      Intern Med (in press)

    • NAID

      10015567420

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390240
  • [Patent] 新規アポトーシス誘導リガンド(ORAIP)を標的とする肺動脈肺高血圧症(PAH)に対する新たな抗体医薬の開発2020

    • Inventor(s)
      世古義規 村山季美枝 藤村務 前村浩二 江口正倫 森貴子
    • Industrial Property Rights Holder
      世古義規 村山季美枝 藤村務 前村浩二 江口正倫 森貴子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-19K08519
  • [Patent] 新規アポトーシス誘導リガンド(ORAIP)を標的とする肺動脈肺高血圧症(PAH)に対する新たな抗体医薬の開発2020

    • Inventor(s)
      世古義規 村山季美 枝 藤村務 前村浩 二 江口正倫 森貴
    • Industrial Property Rights Holder
      世古義規 村山季美 枝 藤村務 前村浩 二 江口正倫 森貴
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Acquisition Date
      2020
    • Data Source
      KAKENHI-PROJECT-19K08519
  • 1.  TOBE Kazuyuki (30251242)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 2.  NAGAI Ryozo (60207975)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 3.  YAMAZAKI Tsutomu (60251245)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  YAZAKI Yoshio (20101090)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  KURABAYASHI Masahiko (00215047)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  MISAKI Yoshikata (60219615)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  YAMAMOTO Kazuhiko (80191394)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  KOMURO Issei (30260483)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  KURIHARA Hiroki (20221947)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  ENOKAWA Yoshifumi
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  高橋 直之
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  ARAI Masashi (60270857)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  SAKURAI Takeshi (60251055)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  SHINDO Takayuki (90345215)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  EGUCHI Masamichi (70585405)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  高橋 利之 (40236302)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  杉浦 清了 (10272551)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  土持 英嗣 (90197715)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  久保田 俊一郎 (00260480)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  中井 秀和 (40837671)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  藤田 靖之 (00590465)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  山中 勝弘 (70729384)
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  • 23.  川本 篤彦 (00275330)
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  • 24.  岡田 健次 (90284356)
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  • 25.  前村 浩二 (90282649)
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  • 27.  磯田 菊生 (00532475)
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  • 28.  渋谷 智義 (60365616)
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  • 29.  中島 章人 (30439294)
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  • 30.  KATOH Hirohisa
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  • 31.  KANGAWA Kenji
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  • 32.  方 榮哲
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  • 33.  広井 透雄
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  • 34.  塩島 一朗
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