AOYAMA Nobuo 青山伸郎

… Alternative Names

青山伸朗アオヤマノブオ

青山信郎アオヤマノブオ

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Researcher Number	30243299
Affiliation (based on the past Project Information) *help	2002 – 2004: Kobe Univ.University Hospital Associate Professor, 医学部附属病院, 助教授 2003: Kobe University School of Medicine, Kobe University Hospital, Associate Professor, 医学部付属病院, 助教授 1998 – 2001: Kobe University School of Medicine, Assocaite Professor, 医学部・附属病院, 助教授 1998: 神戸大学, 医学部附属病院, 助教授 1992 – 1997: 神戸大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology / Bacteriology (including Mycology) / 応用薬理学・医療系薬学 / Medical pharmacy / 内分泌・代謝学
Keywords	Principal Investigator p53 / apoptosis / multidrug resistance / colorectal carcinoma / replication error / MDR / 大腸癌 / RER / アポトーシス / p53遺伝子 … More Except Principal Investigator … More MDR1 / SAP-1 / チロシンホスファターゼ / 消化器癌 / CYP3A / mRNA / Caco-2 / bacterial toxin / VacA toxin / vacuolating cytotoxin / VacA / ヘリコバクター・ピロリ / 細菌毒素 / 毒性発現 / VacA毒素 / 空胞化毒素 / ヘリコバクター / CYP2C19 / PTPH1 / HDC / Gastrointestinal cancer / CEA / Cyclosporine / Digixin / Pharmacogenetics / Pharmacogenomics / Genotyping / Gene / Drug transporters / ジゴキシン / ファーマコジュネティクス / MDRI / シクロスポリン / ファーマコジェネティクス / ファーマコゲノミクス / 遺伝子診断 / 遺伝子 / トランスポーター / 薬物輸送担体 / Toxin comparison / diseases / Helicobocter pylori / ヘリコバクター・ピロリ感染症 / 多形比較 / 多様な疾患 / MRP1 / Real time PCR / Human duodenal enterocytes / ヒト十二指腸上皮細胞 / MRP / リアルタイムPCR / 十二指腸上皮細胞 / vaccine / toxicity / Helicobacier pylori / 病原遺伝子群 / ワクチン開発 / CagPAI / 成分ワクチン / ワクチン / gastric pH monitoring / plasma concentration / anti-H.pylori therapy / Helicobacter pylori / lansoprazole / omeprazole / genotype / 胃内PHモニタリング / ランソプラゾ-ル / オメプラゾ-ル / 胃内pHモンタリング / 胃内pHモニタリング / 薬物血中濃度 / 除菌治療 / ピロリ / ランソプラゾール / オメプラゾール / 遺伝子型 / Cell adhesion / Protein tyrosine phosphatase / Ezrin / 細胞接着 / DTPHI / histamine / gastrin / 胃粘膜上皮細胞 / トランスジェニックマウス / 分化-増殖 / 被蓋上皮細胞 / 増殖 / 分化 / 胃粘膜 / ヒスタミン / ガストリン / Inhibitor / Antibody / Protein tyrosine phosphatse / 腫瘍マーカー / モノクローナル抗体 / チロシンガスファターゼ / 阻害剤 / 抗体 / テロシンホスファターゼ / glucose transporter gene / IRS-1 gene / mitochondrial gene / glucokinase gene / insulin receptor gene / インスリン受容体異常症 / NIDDM / 糖輸送担体遺伝子 / IRS-1遺伝子 / ミトコンドリア遺伝子 / グルコキナーゼ遺伝子 / インスリン夛容体遺伝子 / キロシンホスファターゼ / SHPS-1 / SHP-2 / 増殖因子 / Ras Less

Order-made pharmacotherapy based on MDR1 genotyping
- Principal Investigator
  
  SAKAEDA Toshiyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kobe University
Research for comparison of VacA in H. pylori infectious diseases
- Principal Investigator
  
  HIRAYAMA Toshiya
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
Basic research for H. pylori component vaccine
- Principal Investigator
  
  HITAYAMA Toshiya
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
Real time PCR analysis of transporter and metabolism enzyme expression level in human alimentary canal epidermic cell
- Principal Investigator
  
  SAKAEDA Toshiyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  KOBE UNIVERSITY
Role of Cytochrome P450 2C19 Genotypes in Anti-Helicobacter Pylori Therapy with Proton Pump Inhibitors
- Principal Investigator
  
  SAKAEDA Toshiyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kobe University
Gastrin controls growth and differentiation of mouse gastric pit cells.
- Principal Investigator
  
  KONDA Yoshitaka
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  KYOTO UNIVERSITY
  Gunma University
Research for a protein tyrosine phosphatase for cell adhesion and its mutations in gastrointestinal cancers.
- Principal Investigator
  
  MATOZAKI Takashi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kobe University
Ras活性化機構におけるチロシンホスファターゼの機能に関する研究
- Principal Investigator
  
  的崎尚
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
大腸癌に高発現するチロシンホスファターゼSAP-1の生理機能に関する研究
- Principal Investigator
  
  的崎尚
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kobe University
Basic research and clinical application of SAP-1, a protein tyrosine phosphatase expressed in gastrointestinal cancers.
- Principal Investigator
  
  MATOZAKI Takashi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Kobe University
Mechanism of Fas-mediated apoptosis in p53-transfected human colon carcinoma cells (WiDr)Principal Investigator
- Principal Investigator
  
  AOYAMA Nobuo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kobe University
消化器癌におけるチロシンホスファターゼの癌性変異に関する研究
- Principal Investigator
  
  MATOZAKI Takashi
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kobe University
Role of gene mutations in development of diabetes mellitus
- Principal Investigator
  
  KASUGA Masato
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kobe University

All 2003 2002 2001

All Journal Article

[Journal Article] MDR1 genotype-related duodenal absorption rate of digoxin in healthy Japanese subjects2003
- Author(s)
  Y.Morita, T.Sakaeda, M.Horinouchi, T.Nakamura, K.Kuroda, I.Miki, K.Yoshimura, T.Sakai, D.Shirasaka, N.Aoyama, M.Kasuga, K.Okumura
- Journal Title
  
  Pharm.Res.(PMID: 12739761) 20(4)
  
  Pages: 552-556
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590130
[Journal Article] Significant genetic linkage of MDR1 polymorphisms at positions 3435 and 2677 : functional relevance to pharmacokinetics of digoxin2002
- Author(s)
  M.Horinouchi, T.Sakaeda, T.Nakamura, Y.Morita, T.Tamura, N.Aoyama, M.Kasuga, K.Okumura
- Journal Title
  
  Pharm.Res.(PMID: 12425480) 19(10)
  
  Pages: 1581-1585
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590130
[Journal Article] Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects2002
- Author(s)
  T.Nakamura, T.Sakaeda, M.Horinouchi, T.Tamura, N.Aoyama, T.Shirakawa, M.Matsuo, M.Kasuga, K.Okumura
- Journal Title
  
  Clin.Pharmacol.Ther. (PMID: 11956513) 71(4)
  
  Pages: 297-303
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590130
[Journal Article] Effects of polymorphisms of MDR1, MRP1, and MRP2 genes on their mRNA expression levels in duodenal enterocytes of healthy Japanese subjects2002
- Author(s)
  Y.Moriya, T.Nakamura, M.Horinouchi, T.Sakaeda, T.Tamura, N.Aoyama, T.Shirakawa, A.Gotoh, S.Fujimoto, M.Matsuo, M.Kasuga, K.Okumura
- Journal Title
  
  Biol.Pharm.Bull(PMID: 12392094) 25(10)
  
  Pages: 1356-1359
- NAID
  110003638910
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590130
[Journal Article] MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects2001
- Author(s)
  T.Sakaeda, T.Nakamura, M.Horinouchi, M.Kakumoto, N.Ohmoto, T.Sakai, Y.Morita, T.Tamura, N.Aoyama, M.Hirai, M.Kasuga, K.Okumura
- Journal Title
  
  Pharm.Res.(PMID: 11697464) 18(10)
  
  Pages: 1400-1404
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590130

1. MATOZAKI Takashi (80252782)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. SAKAEDA Toshiyuki (00304098)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
3. OKUMURA Katsuhiko (60025707)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
4. HITAYAMA Toshiya (50050696)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. HAYASHI Yoshitaka (50189669)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. WADA Akihiro (70253698)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KASUGA Masato (50161047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YOKONO Koichi (50144580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TAKAHASHI Rei (60144565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MAEDA Sakan (50030911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KITAGAWA Motoji (80262898)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. TAKEYAMA Yoshifumi (70263374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KONDA Yoshitaka (90261867)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TAKEUCHI Toshiyuki (00109977)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. CHIBA Tsutomu (30188487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MAKINO Souichi (30181621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. YAHIRO Kinnosuke (80345024)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KURAZONO Hisao (90186487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. NAKAJIMA Motoo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SHIRASAKA Daisuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 岸本美也子

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

AOYAMA Nobuo 青山 伸郎

青山 伸朗 アオヤマ ノブオ

青山 信郎 アオヤマ ノブオ

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Mechanism of Fas-mediated apoptosis in p53-transfected human colon carcinoma cells (WiDr)Principal Investigator

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[Journal Article] MDR1 genotype-related duodenal absorption rate of digoxin in healthy Japanese subjects2003

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Data Source

[Journal Article] Significant genetic linkage of MDR1 polymorphisms at positions 3435 and 2677 : functional relevance to pharmacokinetics of digoxin2002

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Description

AOYAMA Nobuo 青山伸郎

青山伸朗アオヤマノブオ

青山信郎アオヤマノブオ