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AKAGI KIWAMU  赤木 究

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Akagi Kiwamu  赤木 究

AKAGI Kiwamu  赤木 究

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Researcher Number 30244114
Other IDs
Affiliation (Current) 2025: 国際医療福祉大学, 国際医療福祉大学成田病院, 教授
Affiliation (based on the past Project Information) *help 2022 – 2023: 地方独立行政法人埼玉県立病院機構埼玉県立がんセンター(臨床腫瘍研究所), 病院 腫瘍診断・予防科, 科長(兼)診療部長
2021: 地方独立行政法人埼玉県立病院機構埼玉県立がんセンター(臨床腫瘍研究所), 病院 腫瘍診断・予防科, 科長(兼)部長
2016 – 2020: 埼玉県立がんセンター(臨床腫瘍研究所), 病院 腫瘍診断・予防科, 科長(兼)部長
2015: 埼玉県立がんセンター(臨床腫瘍研究所), その他部局等, その他
2000: 埼玉県立がんセンター研究所, 室長
1999 – 2000: 埼玉県立がんセンター, 研究所, 研究員
Review Section/Research Field
Principal Investigator
Human genetics
Except Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 58:Society medicine, nursing, and related fields / Biological pharmacy / Biological Sciences
Keywords
Principal Investigator
がん関連遺伝子 / RNAシークエンス / 胚細胞性変異 / 原因遺伝子 / 若年癌 / 分子バーコード / RNAシーケンス / MSI検査 / パネル検査 / 若年性大腸癌 … More / DKC1 / シーケンス / 大腸がん / 若年がん … More
Except Principal Investigator
ミスマッチ修復遺伝子 / 遺伝性腫瘍症候群 / リンチ症候群 / コホート研究 / NK活性 / 遺伝子治療 / トランスジェニックマウス / アンチセンス / 融合遺伝子 / 白血病 / リボザイム / バリアント / 遺伝学的検査 / Lynch-like syndrome / 医療の地域間格差 / 家系単位での遺伝医療 / 遠隔診療ネットワーク / 遺伝診療 / 遺伝性腫瘍 / オンライン診療 / 免疫チェックポイント阻害剤 / 次世代シーケンサー / 大腸がん / MSH6 / 大腸癌 / NSG / 胃がん / MSI検査 / NGS / ミスマッチ修復 / マイクロサテライト不安定性 / Immunosurveillance / NK activity / Prospective cohort study / 免疫監視 / マイクロアレイ / 遺伝子 / 遺伝子発現プロファイル / 機能ゲノム科学 / 創薬 / 緑茶 / エストロゲンレセプター / がん化学予防 / 発がんリスク / EGCG / hnRNP / エストロゲンレセプターα / H.pylori / 免疫 / H. pylori / 血清α_2-グロブリン / 前がん病変マーカー / hnRNP B1 / Tip(TNF-α inducing protein) / がん予防 / NKG2D / 乳がん / 肺がん / ピロリ菌 / コーホート研究 / 遺伝子多型 Less
  • Research Projects

    (9 results)
  • Research Products

    (18 results)
  • Co-Researchers

    (27 People)
  •  Lynch-like syndrome include hereditary cases difficult to diagnose.

    • Principal Investigator
      山本 剛
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Research Institute for Clinical Oncology Saitama Cancer Center
  •  オンライン遺伝診療:家系単位での遺伝医療を実現する遠隔診療ネットワークの構築

    • Principal Investigator
      植野 さやか
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 58:Society medicine, nursing, and related fields
    • Research Institution
      Okayama University
  •  Quantification of microsatellite instability tests improves detection sensitivity of MSI-H

    • Principal Investigator
      Yamamoto Gou
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Research Institute for Clinical Oncology Saitama Cancer Center
  •  Analysis of responsible genes in early-onset colorectal cancerPrincipal Investigator

    • Principal Investigator
      Akagi Kiwamu
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human genetics
    • Research Institution
      Research Institute for Clinical Oncology, Saitama Cancer Center
  •  白血病の原因となる融合遺伝子mRNAを標的とするリボザイムの設計

    • Principal Investigator
      神津 知子
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Research Institute for Clinical Oncology, Saitama Cancer Center
  •  がん関連遺伝子発現の個体差と宿主・環境要因に関する研究

    • Principal Investigator
      NAKACHI Kei
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Radiation Effects Research Foundation
      Research Institute for Clinical Oncology, Saitama Cancer Center
  •  創薬、医療を目的とした「機能ゲノム科学」の戦略的手法の樹立

    • Principal Investigator
      内田 和彦
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      University of Tsukuba
  •  白血病の原因となる融合遺伝子mRNAを標的とするリボザイムの設計

    • Principal Investigator
      神津 知子
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Research Institute for Clinical Oncology, Saitama Cancer Center
  •  DEVELOPMENT OF BIOLOGICAL MARKERS FOR INDIVIDUAL CANCER RISK AND CANCER PREVENTION ON THE BASIS OF A PROSPECTIVE COHORT STUDY

    • Principal Investigator
      NAKACHI Kei
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Research Institute for Clinical Oncology, Saitama Cancer Center

All 2023 2020 2019 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] Concordance between microsatellite instability testing and immunohistochemistry for mismatch repair proteins and efficient screening of mismatch repair deficient gastric cancer2023

    • Author(s)
      Yamamoto G, Ito T, Suzuki O, Kamae N, Kakuta M, Takahashi A, Iuchi K, Arai T, Ishida H, Akagi K.
    • Journal Title

      Oncologic Letters

      Volume: 26 Issue: 5

    • DOI

      10.3892/ol.2023.14081

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07266
  • [Journal Article] Quantitative evaluation of MSI testing using NGS detects the imperceptible microsatellite changed caused by MSH6 deficiency2020

    • Author(s)
      Yamamoto Gou、Takenoya Takashi、Takahashi Akemi、Osanai Yukiko、Kakuta Miho、Tachikawa Tetsuhiko、Washio Takanori、Kamiyama Masato、Shiibashi Michio、Yamaguchi Shigeki、Akagi Kiwamu
    • Journal Title

      Familial Cancer

      Volume: 20 Issue: 2 Pages: 137-143

    • DOI

      10.1007/s10689-020-00203-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07339
  • [Journal Article] SVA retrotransposon insertion in exon of MMR genes results in aberrant RNA splicing and causes Lynch syndrome2020

    • Author(s)
      Yamamoto Gou、Miyabe Izumi、Tanaka Keisuke、Kakuta Miho、Watanabe Motoko、Kawakami Satoru、Ishida Hideyuki、Akagi Kiwamu
    • Journal Title

      European Journal of Human Genetics

      Volume: 29 Issue: 4 Pages: 680-686

    • DOI

      10.1038/s41431-020-00779-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07339
  • [Journal Article] Development of metachronous rectal cancers in a young man with dyskeratosis congenita: a case report.2019

    • Author(s)
      Watanabe M, Yamamoto G, Fujiyoshi K, Akagi Y, Kakuta M, Nishimura Y, Akagi K.
    • Journal Title

      J Med Case Rep.

      Volume: 13 Issue: 1 Pages: 117-122

    • DOI

      10.1186/s13256-019-2044-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08335
  • [Journal Article] Routine genetic testing of lung cancer specimens derived from surgery, bronchoscopy and fluid aspiration by next generation sequencing2017

    • Author(s)
      Gou Yamamoto, Mari Kikuchi, Shiho Kobayashi, Yoshiko Arai, Kenji Fujiyoshi, Tomokazu Wakatsuki, Miho Kakuta, Yuki Yamane, Yoshihito Iijima, Hideaki Mizutani, Yuki Nakajima, Junko Sudo, Hiroyasu Kinoshita, Futoshi Kurimoto, Hirohiko Akiyama, Hidetaka Uramoto, Hiroshi Sakai, Yoshito Akagi, Kiwamu Akagi
    • Journal Title

      International journal of oncology

      Volume: 50 Issue: 5 Pages: 1579-1589

    • DOI

      10.3892/ijo.2017.3935

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08335, KAKENHI-PROJECT-17K10803
  • [Presentation] ミスマッチ修復遺伝子におけるStructural variationの解析2023

    • Author(s)
      山本 剛、高橋 朱実、井内 勝哉、藤本 祐未、加藤 幹人、柳 弘子、若月 智和、小山内 由希子、平田 友美、角田 美穂、赤木 究
    • Organizer
      第29回日本遺伝性腫瘍学会
    • Data Source
      KAKENHI-PROJECT-22K07266
  • [Presentation] オンライン遺伝診療の実施状況と課題に対する意識調査2023

    • Author(s)
      植野さやか, 浦川優作, 植木有紗, 吉田玲子, 赤木究, 田村和朗, 平沢晃
    • Organizer
      日本遺伝性腫瘍学会 第29回学術集会
    • Data Source
      KAKENHI-PROJECT-21K19667
  • [Presentation] An update on hereditary tumors Construction of Integrated Database of Clinical and Genetic Information for Lynch syndrome in Japan2018

    • Author(s)
      赤木 究, 山本 剛, 松下 一之, 檜井 孝夫, 横井 左奈, 田中屋 宏爾, 松原 長秀, 冨田 尚裕, 石田 秀行
    • Organizer
      第77回日本癌学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K08335
  • [Presentation] 多数の大腸腺腫を併発した日本人若年発症直腸癌患者におけるMBD4遺伝子生殖細胞系列病的変異の同定と直腸癌組織における体細胞変異プロファイルの解析2018

    • Author(s)
      江口 英孝、田中屋 宏爾、田夛 祐喜、立川 哲彦、平田 智子、神田 将和、 井谷 史嗣、赤木 究、岡崎 康司、石田 秀行
    • Organizer
      第24回日本家族性腫瘍学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K08335
  • [Presentation] NGSを用いたCNV検出によるLynch症候群病的バリアントの確定2018

    • Author(s)
      山本 剛、宮部 泉、高橋 朱実、須藤 久美子、石川 志帆、新井 吉子、菊地 茉莉、田中 桂輔、若月 智和、立川 哲彦、角田 美穂、横井 左奈、檜井 秀夫、松下 一之、赤木 究
    • Organizer
      第24回日本家族性腫瘍学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K08335
  • [Presentation] Multi-gene panel を用いた遺伝性大腸がんの遺伝子診断2018

    • Author(s)
      赤木 究、山本 剛、宮部泉、角田美穂、若月智和、田中佳輔、中村 篤大、山下 健太郎、山口達郎、三口真司、須藤剛、 永坂 岳司、塩澤学、中野 雄介、野水整、安田有里、主藤朝也、稲田麻里、賀川義規、富田佳典
    • Organizer
      日本人類遺伝学会第63回大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K08335
  • [Presentation] Analyzing pathogenic variants in Lynch syndrome by DNA and RNA sequencing2018

    • Author(s)
      山本 剛, 新井 吉子, 立川 哲彦, 赤木 究
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-15K08335
  • [Presentation] 遺伝性腫瘍症候群 -治療とがん予防-2017

    • Author(s)
      赤木究
    • Organizer
      第76回日本癌学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K08335
  • [Presentation] 遺伝性大腸がん及びポリポーシス症候群:リンチ症候群と家族性大腸腺腫症2017

    • Author(s)
      赤木究
    • Organizer
      第15回日本臨床腫瘍学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K08335
  • [Presentation] Molecular features of microsatellite instability-high colorectal cancer and mutation spectrum of Lynch syndrome identified by universal tumor screening.2017

    • Author(s)
      Kiwamu Akagi, Miho Kakuta, Gou Yamamoto, Kenji Fujiyoshi, Yoji Nishimura, Yoshito Akagi, Hirohiko Sakamoto.
    • Organizer
      InSiGHT 7TH BIENNIAL meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08335
  • [Presentation] リンチ症候群の臨床ゲノムデータベース構築に向けた取り組み2017

    • Author(s)
      山本剛,角田美穂,新井冨生,石田秀行,岡﨑康司,隈元謙介,田中屋宏爾,永坂岳司,野水 整,檜井孝夫,三口真司,松原長秀,山口達郎,山下健太郎,赤木究
    • Organizer
      第23回家族性腫瘍学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K08335
  • [Presentation] 日本家族性腫瘍学会におけるゲノムデータベース構築2017

    • Author(s)
      赤木究
    • Organizer
      第23回家族性腫瘍学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K08335
  • [Presentation] Mutation spectrum of Japanese Lynch syndrome patients diagnosed by Universal tumor screening for colorectal cancer2016

    • Author(s)
      Kiwamu Akagi
    • Organizer
      ICHG
    • Place of Presentation
      京都
    • Year and Date
      2016-04-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08335
  • 1.  Yamamoto Gou (80384189)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 12 results
  • 2.  高橋 朱実 (40743620)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 3.  NAKACHI Kei (00142117)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  IMAI Kazue (80260230)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  神津 知子 (60161874)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  末岡 榮三朗 (00270603)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  角田 美穂 (60347359)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 8.  MATSUYAMA Satoru (90311373)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  EGUCHI Hidetaka (00260232)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  福山 朋房 (10300906)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  林 慎一 (60144862)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  菅沼 雅美 (20196695)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  三宅 智 (00332346)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  大倉 康男 (30312284)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  内田 和彦 (90211078)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  斉藤 俊行 (90205667)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  田中 利男 (00135443)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  辻本 豪三 (80172013)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  村上 康文 (90200279)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  宮部 泉 (20800155)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 21.  植野 さやか (80848937)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 22.  田村 和朗 (20278823)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 23.  平沢 晃 (90296658)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 24.  吉田 玲子 (10421166)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 25.  植木 有紗 (60445319)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 26.  井内 勝哉 (40553847)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 27.  SHARP G・B
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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