NAGAKI Masahito 永木正仁

Researcher Number	30293559
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2013: 岐阜大学, 医学部, 非常勤講師 2011 – 2013: 岐阜大学, 医学(系)研究科(研究院), 非常勤講師 2010: 岐阜大学, 医学部附属病院, 臨床教授 2009 – 2010: 岐阜大学, 医学部附属病院, 准教授 2007 – 2010: Gifu University school of Medicine, Dpearment of Gastmenterology, Associate professor … More 2008: 岐阜大学, 医学部附属病院, 臨床教授 2005 – 2006: 岐阜大学, 大学院医学系研究科, 助教授 2005: GIFU UNIVERSITY, GRADUATE SHOOL OF MEDICINE, ASSOCIATE PROFESSOR, 大学院・医学系研究科, 助教授 2003 – 2004: 岐阜大学, 医学部附属病院, 講師 2000: GIFU UNIVERSITY SHOOL OF MEDICINE, FIRST DEPARTMENT OF INTERNAL MEDICINE, ASSISTANT PROFESSOR, 医学部, 助手 1999: 岐阜大学, 医学部・附属病院, 助手 1998: 岐阜大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology Except Principal Investigator Gastroenterology
Keywords	Principal Investigator 転写因子 / TRANSCRIPTION FACTOR / EXTRACELLULAR MATRIX / ACUTE HEPATIC FAILURE / 細胞外マトリックス / 急性肝不全 / 遺伝子治療 / 再生医療 / 肝不全 / CELL TRANSPLANTATION … More / REGENERATION THERAPY / EHSゲル / HNF-4 / 肝幹細胞 / 人工肝臓 / 再生療法 / 細胞移植 / GENE THERAPY / BAIOARTIFICIAL LIVER / バイオ人工肝 / 肝炎 … More Except Principal Investigator small interference RNA / B型肝炎ウイルス / RNA technology / antiviral drug / Hepatitis B virus / ウイルス複製 / RNA工学 / マウス / 創薬 / 感染症 / 抗ウイルス薬 / siRNA / サイトカイン / 慢性肝炎 / 治療ワクチン / ワクチン / HCV / CD44 / 接着因子 / 肝障害 / ケモカイン / CTL / 免疫 / 肝臓学 Less

Development of the novel therapeutic vaccine using persistent viral hepatitis infection model
- Principal Investigator
  
  KIMURA Kiminori
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
The analysis of inflammatory cascade between antigen specific CTLs and liver injury using hepatitis model
- Principal Investigator
  
  KIMURA Kiminori
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Development of regenerative medicine and therapeutic system for hepatic failure applied by hepatocyte nuclear factor 4Principal Investigator
- Principal Investigator
  
  NAGAKI Masahito
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
The study of anti-hepatitis B virus drugs using RNA technology
- Principal Investigator
  
  KIMURA Kiminori
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
  Gifu University
STUDIES ON DIFFERENTIATION AND REGENERATION OF FETAL LIVER STEM CELLS AND THEIR APPLICATION FOR HEPATIC FAILUREPrincipal Investigator
- Principal Investigator
  
  NAGAKI Masahito
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  GIFU UNIVERSITY
DEVELOPMENT OF BIOARTIFICIAL LIVERPrincipal Investigator
- Principal Investigator
  
  NAGAKI Masahito
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University

All 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002

All Journal Article Presentation

[Journal Article] Role of interleukin-18 in intrahepatic inflammatory cells recruitment in acute liver injury.2011
- Author(s)
  Kimura K, Sekiguchi S, Hayashi S, Hayashi y, Hishima T, Nagaki M, Kohara M.
- Journal Title
  
  Journal of Leukocyte Biology
  
  Volume: 89(3) Pages: 433-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591004
[Journal Article] Imaging the recruitment of cancer-associated fibroblasts by liver-metastatic colon cancer.2011
- Author(s)
  Suetsugu A, Osawa Y, Nagaki M, Saji S, Moriwaki H, Bouvet M, Hoffman RM.
- Journal Title
  
  J Cell Biochem
  
  Volume: 112 Pages: 949-953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression.2011
- Author(s)
  Osawa Y, Seki E, Kodama Y, Suetsugu A Miura K, Adachi M, Ito H, Shiratori Y, Banno I, Olefsky JM, Nagaki M, Moriwaki H, Brenner DA, Seishima M.
- Journal Title
  
  FASEB J
  
  Volume: 25 Pages: 1133-1144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Role of interleukin-18 in intrahepatic inflammatory cells recruitment in acute liver injury.2011
- Author(s)
  Kimura K, Sekiguchi S, Hayashi S, Hayashi y, Hishima T, Nagaki M, Kohara M
- Journal Title
  
  Journal of Leukocyte Biology 89(3)
  
  Pages: 433-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390203
[Journal Article] Role of interleukin-18 in intrahepatic inflammatory cell recruitment in acute liver injury.2011
- Author(s)
  Kimura K, Sekiguchi S, Hayashi S, Hayashi Y, Hishima T, Nagaki M, Kohara M.
- Journal Title
  
  J Leukocyte Biol
  
  Volume: 89 Pages: 433-442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Role of interleukin-18 in intrahepatic inflammatory cell recruitment in acute liver injury.2011
- Author(s)
  Kimura K, Sekiguchi S, Hayashi S, Hayashi Y, Hishima T, Nagaki M, Kohara M.
- Journal Title
  
  J Leukocyte Biol 89
  
  Pages: 433-442
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Role of interleukin-18 in intrahepatic inflammatory cell recruitment in acute liver injury2011
- Author(s)
  Kimura K, Sekiguchi S, Hayashi S, Hayashi Y, Hishima T, Nagaki M, Kohara M.
- Journal Title
  
  J Leukoc Biol
  
  Volume: Mar;89(3) Issue: 3 Pages: 433-42
- DOI
  10.1189/jlb.0710412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591004
[Journal Article] Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression.2011
- Author(s)
  Osawa Y, Seki E, Kodama Y, Suetsugu A, Miura K, Adachi M, Ito H, Shiratori Y, Banno Y, Olefsky JM, Nagaki M, Moriwaki H, Brenner DA, Seishima M.
- Journal Title
  
  FASEB J 25
  
  Pages: 1133-1144
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression.2011
- Author(s)
  Osawa Y, Seki E, Kodama Y, Suetsugu A, Miura K, Adachi M, Ito H, Shiratori Y, Banno Y, Olefsky JM, Nagaki M, Moriwaki H, Brenner DA, Seishima M
- Journal Title
  
  FASEB J. 25(4)
  
  Pages: 1133-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390203
[Journal Article] Is there a delayed gastric emptying of patients with early-stage, untreated Parkinson's disease? An analysis using the 13C-acetate breath test.2011
- Author(s)
  Tanaka Y, Kato T, Nishida H, Yamada M, Koumura A, Sakurai T, Hayashi Y, Kimura A, Hozumi I, Araki H, Murase M, Nagaki M, Moriwaki H, Inuzuka T
- Journal Title
  
  J Neurol. 258(3)
  
  Pages: 421-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390203
[Journal Article] Imaging the recruitment of cancer-associated fibroblasts by liver-metastatic colon cancer.2011
- Author(s)
  Suetsugu A, Osawa Y, Nagaki M, Saji S, Moriwaki H, Bouvet M, Hoffman RM.
- Journal Title
  
  J Cell Biochem 112
  
  Pages: 949-953
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Roles of CD44 in chemical-induced liver injury.2010
- Author(s)
  Kimura K, Hayashi S, Nagaki M
- Journal Title
  
  Curr Opin Drug Discov Devel. 13(1)(Review)
  
  Pages: 96-103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390203
[Journal Article] Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice.2010
- Author(s)
  Osawa Y, Seki E, Adachi M, Suetsugu A, Ito H, Moriwaki H, Seishima M, Nagaki M
- Journal Title
  
  Hepatology. 51(1)
  
  Pages: 237-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390203
[Journal Article] Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice.2010
- Author(s)
  Osawa Y, Seki E, Adachi M, Suetsugu A, Ito H, Moriwaki H, Seishima M, Nagaki M.
- Journal Title
  
  Hepatology 51
  
  Pages: 237-245
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Simultaneous color-coded imaging to distinguish cancer "stem-like" and non-stem cells in the same tumor.2010
- Author(s)
  Suetsugu A, Osawa Y, Nagaki M, Moriwaki H, Saji S, Bouvet M, Hoffman RM.
- Journal Title
  
  J Cell Biochem
  
  Volume: 111 Pages: 1035-1041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Elevated serum tumor necrosis factor-alpha and soluble tumor necrosis factor receptors correlate with aberrant energy metabolism in liver cirrhosis.2010
- Author(s)
  Shiraki M, Teramura Y, Twasa J, Shimizu M, Miwa Y, Murakami N, Nagaki M, Moriwaki H.
- Journal Title
  
  Nutrition
  
  Volume: 26 Pages: 269-275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Insulin resistance raises the risk for recurrence of stage I hepatocellularcarcinoma after curative radiofrequency ablation in HCV-positive patiens : A prospective, case-series study.2010
- Author(s)
  Tmai K, Takai K, Nisnigaki Y, Shimizu S, Naiki T, Hayashi H, Uematsu T, Sugihara J, Tomita E, Shimizu M, Nagaki M, Moriwaki H.
- Journal Title
  
  Hepatol Res
  
  Volume: 40 Pages: 376-382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Roles of CD44 in chemical-induced liver injury.2010
- Author(s)
  Kimura K, Hayashi S, Nagaki M.
- Journal Title
  
  Curr Opin Drug Disc
  
  Volume: 13 Pages: 96-103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Simultaneous color-coded imaging to distinguish cancer "stem-like" and non-stem cells in the same tumor.2010
- Author(s)
  Suetsugu A, Osawa Y, Nagaki M, Moriwaki H, Saji S, Bouvet M, Hoffman RM
- Journal Title
  
  J Cell Biochem 111
  
  Pages: 1035-1041
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Roles of CD44 in chemical-induced liver injury.2010
- Author(s)
  Kimura K, Hayashi S, Nagaki M.
- Journal Title
  
  Curr Opin Drug Disc 13
  
  Pages: 96-103
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Role or acid sphingomyelinase of Kuptter cells in cholestaticiver injury in mice.2010
- Author(s)
  Osawa Y, Seki E, Adachi M, Suetsugu A, Ito H, Moriwaki H, Seishima M, Nagaki M.
- Journal Title
  
  Hepatology
  
  Volume: 51 Pages: 237-245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Extended treatment duration of peginterferon-alpha2b plus ribavirin for 72 and 96 weeks in hepatitis C genotype 1-infected late responders.2009
- Author(s)
  Nagaki M, Shimizu M, Sugihara JI, Tomita E, Sano C, Naiki T, Kimura K, Amano K, Sakai T, Ninomiya M, Kojima T, Katsumura N, Fujimoto M, Moriwaki H
- Journal Title
  
  Aliment Pharmacol Ther. 30(4)
  
  Pages: 343-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390203
[Journal Article] Effect of CD44 blocking for CTL-induced acute liver injury in the hepatitis B virus transgenic mice.2009
- Author(s)
  Kimura K, Nagaki M, Saio M, Moriwaki M, Kakimi K
- Journal Title
  
  J gastroenterology 44(3)
  
  Pages: 218-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390203
[Journal Article] Extended treatment duration of peginterferon-alpha2b plus ribavirin for 72 and 96 weeks in hepatitis C genotype 1-infected late responders2009
- Author(s)
  Nagaki, et al.
- Journal Title
  
  Aliment Pharmacol Ther. 15;30(4)
  
  Pages: 343-351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390203
[Journal Article] Role of CD44 on CTL-induced acute liver injury in hepatitis B virus transgenic mice.2009
- Author(s)
  Kimura K, Nagaki M Saio M, Hosoi A, Saeki T, Okuda Y, Kuwata K, Moriwaki H, Kakimi K.
- Journal Title
  
  J Gastroentel 44
  
  Pages: 218-227
- NAID
  10025173826
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Pathological role of CD44 on NKT cells in carbon tetrachloride-mediated liver injury.2009
- Author(s)
  Kimura K, Nagaki M, Matsura T, Moriwaki H, Kakimi K
- Journal Title
  
  Hepatol Res 39(1)
  
  Pages: 93-105
- NAID
  10025324211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390203
[Journal Article] Extracellular matrix is required for the survival and differentiation of transplanted hepatic progenitor cells.2009
- Author(s)
  Tsukada Y, Nagaki M, Suetsugu A, Osawa Y, Moriwaki H
- Journal Title
  
  Biochem Biophys Res Common 381
  
  Pages: 733-737
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Role of CD44 on CTL-induced acute liver injury in hepatitis B virus transgenic mice.2009
- Author(s)
  Kimura K, Nagaki M, Saio M, Hosoi A, Saeki T, Okuda Y, Kuwata K, Moriwaki H, Kakimi K.
- Journal Title
  
  J Gastroentel 44
  
  Pages: 218-227
- NAID
  10025173826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Pathological role of CD44 on NKT cells in carbon tetrachloride-mediated liver injury.2009
- Author(s)
  Kimura K, Nagaki M, Matsuura T, Moriwaki H, Kakimi K.
- Journal Title
  
  Hepatol Res 39
  
  Pages: 93-105
- NAID
  10025324211
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Extracellular matrix is required for the survival and differentiation of transplanted hepatic progenitor cells.2009
- Author(s)
  Tsukada Y, Nagaki M, Suetsugu A, Osawa Y, Moriwaki H
- Journal Title
  
  Biochem Biophys Res Commun. 381(4)
  
  Pages: 733-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390203
[Journal Article] Extracellular matrix is required for the survival and differentiation of transplanted hepatic rogenitor cells.2009
- Author(s)
  Tsukada Y, Nagaki M, Suetsugu A, Osawa Y, Moriwaki H
- Journal Title
  
  Biochem Biophys Res Commun 381
  
  Pages: 733-737
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Critical role of CD44 in Hepatotoxin mediated liver injury2008
- Author(s)
  Kimura K, Nagaki M, Kakimi K, Saio M, Saeki T, Okuda Y, Kuwata K, Moriwaki H
- Journal Title
  
  J hepatol 48(6)
  
  Pages: 952-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390203
[Journal Article] 劇症肝炎の発症機序2008
- Author(s)
  永木正仁, 森脇久隆
- Journal Title
  
  臨床消化器内科 23
  
  Pages: 1759-1765
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Critical role of CD44 in hepatotoxin-mediated liver injury.2008
- Author(s)
  Kimura K, Nagaki M, Kakimi K, Saio M, Saeki T, Okuda Y, Kuwata K, Moriwaki H
- Journal Title
  
  J Hepatol 48
  
  Pages: 952-961
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Critical role of CD44 in Hepatotoxin-mediated liver injury2008
- Author(s)
  Kimura K, Nagaki M, Kakimi K, Saio M, e
- Journal Title
  
  Journal of Hepatology
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Transcription factor HNF and hepatocyte differentiation.2008
- Author(s)
  Nagaki M, Moriwaki H
- Journal Title
  
  Ilepatol Res 38
  
  Pages: 961-969
- NAID
  10024304552
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Cyclooxygenase-2 : its paradoxical roles in liver inflammation and fibrosis.2008
- Author(s)
  Osawa Y, Nagaki M.
- Journal Title
  
  Hepatol Res 38
  
  Pages: 772-774
- NAID
  10021945849
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Cyclooxygenase-2 : its paradoxical roles in liver inflammation and fibrosis.2008
- Author(s)
  Osawa Y, Nagaki M.
- Journal Title
  
  Hepatol Res 48
  
  Pages: 772-774
- NAID
  10021945849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Critical role of CD44 in Hepatotoxin-mediated liver injury2008
- Author(s)
  Kimura K, Nagaki M, Kakimi K, Saio M, Saeki T, Okuda Y, Kuwata K, Moriwaki H.
- Journal Title
  
  J hepatol
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Differentiation of mouse hepatic progenitor cells induced by hepatocyte nuclear factor-4 and cell transplantation in mice with liver fibrosis.2008
- Author(s)
  Suetsugu A, Nagaki M, Aoki H, Motohashi T, Kunisada T, Moriwaki H
- Journal Title
  
  Transplantation 86
  
  Pages: 1178-1186
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Transcription factor HNF and hepatocyte differentiation.2008
- Author(s)
  Nagaki M, Moriwaki H.
- Journal Title
  
  Hepatol Res 38
  
  Pages: 961-969
- NAID
  10024304552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Critical role of CD44 in Hepatotoxin-mediated liver injury2008
- Author(s)
  Kimura K, Nagaki M, KakimiK, Saio M, et. al.
- Journal Title
  
  Journal of Hepatology
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] B型肝炎の自然免疫とウイルス排除2008
- Author(s)
  木村公則, 永木正仁, 森脇久隆
- Journal Title
  
  消化器科 45
  
  Pages: 402-408
- Data Source
  KAKENHI-PROJECT-20590770
[Journal Article] Inhibition of nuclear factor-kappa B exacerbates severe liver injury in Hepatitis B virus transgenic mice model2007
- Author(s)
  Satake S, Nagaki M, Kimura k, et al.
- Journal Title
  
  Hepatology Research (in press)
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Intrinsic resistance to TNF-α-induced hepatocyte apoptosis in ICR mice; The role of a short form of cellular FLICE-like inhibitory protein2007
- Author(s)
  Takai S, Nagaki m, Kimura K, wt al.
- Journal Title
  
  Laboratory Investigation (in press)
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Granulocyte colony-stimulating factor impairs liver regeneration in mice through the up-regulation of interleukin-lbe2007
- Author(s)
  Ogiso T, Nagaki M, Kimura K, et. al.
- Journal Title
  
  Journal of Hepatology 47(6)
  
  Pages: 816-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Granulocyte colony-stimulating factor impairs liver regeneration in mice through the up-regulation of interleukin-lbeta.2007
- Author(s)
  Ogiso T, Nagaki M, Kimura K, et. al.
- Journal Title
  
  Journal of Hepatology 47(6)
  
  Pages: 816-5
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Intrinsic resistance to TNF-alpha-induced hepatocyte apoptosis in ICR mice correlates with expression of a short form of c-FLIP2007
- Author(s)
  Takai S, Nagaki M, Imao M, Kimura K, Kozawa O, Moriwaki H.
- Journal Title
  
  Lab Invest 87(6)
  
  Pages: 572-81
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Significant effect of hepatitis C virus specific CTLs on viral clearance in patients with type C chronic hepatitis treated with antiviral agents2007
- Author(s)
  Satake S, Nagaki M, Kimura K, et. al.
- Journal Title
  
  Hepatology Research
- NAID
  10024148453
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] B型肝炎に対する自然免疫の抗ウイルス効果2007
- Author(s)
  木村公則、永木正仁、森脇久隆
- Journal Title
  
  消化器科
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Significant effect of hepatitis C virus specific CTLs on viral clearance in patients with type C chronic hepatitis treated with antiviral agents.2007
- Author(s)
  Satake S, Nagaki M, Kimura K, Naiki T, Hayashi H, Sugihara J, Tomita E, Moriwaki H
- Journal Title
  
  Hepatol Res.
- NAID
  10024148453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390203
[Journal Article] Inhibition of nuclear factor-kappa B induces inflammatory cell migration and exacerbates severe liver injury in hepatitis B virus transgenic mice2007
- Author(s)
  Satake S, Nagaki M, Kimura K, Moriwaki H.
- Journal Title
  
  Hepatol Res 37(7)
  
  Pages: 524-30
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Granulocyte colony-stimulating factor impairs liver regeneration in mice through the up-regulation of interleukin-1beta2007
- Author(s)
  Ogiso T, Nagaki M, Takai S, Tsukada Y, Mukai T, Kimura K, Moriwaki H.
- Journal Title
  
  J Hepatol 47(6)
  
  Pages: 816-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Inhibition of nuclear factor-kappa B induces inflammatory cell migration and exacerbates severe liver injury in hepatitis B virus transgenic mice.2007
- Author(s)
  Satake S, Nagaki M, Kimura K, Moriwaki H.
- Journal Title
  
  Hepatology Research 37(7)
  
  Pages: 524-30
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Significant effect of hepatitis C virus specific CTLs on viral clearance in patients with type C chronic hepatitis treated with antiviral agents2007
- Author(s)
  Satake S, Nagaki M, Kimura K, Naiki T, Hayashi H, Sugihara J, Tomita E, Moriwaki H.
- Journal Title
  
  Hepatol Res
- NAID
  10024148453
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Hepatocyte nuclear factor-4α and -1 small interfering RNA inhibits hepatocyte differentiation induced by extracellular matrix.2006
- Author(s)
  Kimata T, Nagaki M, Ysukada Y, Ogiso T, Moriwaki H.
- Journal Title
  
  Hepatol Res (in press)
- NAID
  10020329511
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] Role of macropharge migration inhibitory factor for CTL-induced liver injury in hepatitis B transgenic mice.2006
- Author(s)
  Kimura K, Nagaki M, Nishihira J, Kuwata K, Moriwaki H, Chisari FV.
- Journal Title
  
  Clin Diagn Lab Immun 13
  
  Pages: 415-419
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] Differential caspase-9-dependent signaling pathway between tumor necrosis factor receptor- and Fas-mediated hepatocyte apoptosis in mice.2006
- Author(s)
  Imao M, Nagaki M, Imose M, Moriwaki H.
- Journal Title
  
  Liver Int 26
  
  Pages: 137-146
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] Actin organization and hepatocyte differentiation are regulated by extracellular matrix via PI 4,5-bisphosphate.2006
- Author(s)
  Kimata T, Nagaki M, Ogiso T, Naiki T, Kato T, Moriwaki H.
- Journal Title
  
  Hepatology (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] Prevention of hepatic fibrosis in nonobese diabetic mice : a critical role for interferon-γ2006
- Author(s)
  Mukai T, Nagaki M, Kimura K, et al.
- Journal Title
  
  Liver International 26
  
  Pages: 1006-1006
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Pathogenic role of B cells in anti-CD40-induced necroinflammatory liver disease2006
- Author(s)
  Kimura K, Moriwaki H, Nagaki M, Saio M, Nakamoto Y, Naito M, Kuwata K, Chisari FV.
- Journal Title
  
  Am J Pathol 168(3)
  
  Pages: 786-95
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Prevention of hepatic fibrosis in nonobese diabetic mice : a critical role for interferon-gamma2006
- Author(s)
  Mukai T, Nagaki M, Imose M, Kimura K, Satake S, Takai S, Moriwaki H.
- Journal Title
  
  Liver Int 26(8)
  
  Pages: 1006-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Role of macrophage migration inhibitory factor in hepatitis B virus-specific cytotoxic-T-lymphocyte-induced liver injury2006
- Author(s)
  Kimura K, Nagaki M, Nishihira J, Satake S, Kuwata K, Moriwaki H.
- Journal Title
  
  Clin Vaccine Immunol 13(3)
  
  Pages: 415-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Pathogenic role of B cells in anti-CD40-caused necroinflammatory liver disease.2006
- Author(s)
  Kimura K, Moriwaki H, Nagaki M, Saio M, Nakamoto Y, Naito M, Kuwata K, Chisari FV.
- Journal Title
  
  Am J Pathol 168
  
  Pages: 786-795
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] Effects of plasma from patients with hepatic failure on function of primary rat hepatocytes in three dimensional culture.2005
- Author(s)
  Nagaki M, Naito T, Ohnishi H, Akaike T, Muto Y, Moriwaki H.
- Journal Title
  
  Liver Int 25
  
  Pages: 1010-1017
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] Prospective study on early virologic response to treatment with interferon alpha-2b plus rebavirin in patients with chronic hepatitis C genotype 1b.2005
- Author(s)
  Nagaki M
- Journal Title
  
  Hepatol Res 33
  
  Pages: 285-291
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] Blockade of neutrophil elastase attenuates severe liver injury in hepatitis B transgenic mice2005
- Author(s)
  Takai S, Kimura K, Nagaki M, Satake S, Kakimi K, Moriwaki H.
- Journal Title
  
  J Virol 79(24)
  
  Pages: 15142-50
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Hepatoprotection against oxidative damage.2005
- Author(s)
  Nagaki M
- Journal Title
  
  Hepatol Res 32
  
  Pages: 9-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] Hepatoprotection against oxidative damage.2005
- Author(s)
  Nagaki M, Moriwaki H.
- Journal Title
  
  Hepatol Res 32
  
  Pages: 9-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] Blockade of neutrophil elastase attenuates severe liver injury in hepatitis B transgenic mice.2005
- Author(s)
  Takai S, Kimura K, Nagaki M, Satake S, Kakimi K, Moriwaki H.
- Journal Title
  
  J Virol 79
  
  Pages: 15142-15150
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] Normal liver regeneration and liver cell apoptosis after partial hepatectomy in tumor necrosis factor-α-deficient mice.2005
- Author(s)
  Hayashi H, Nagaki M, Imose M, Osawa Y, Kimura K, Takai S, Imao M, Naiki T, Kato T, Moriwaki H.
- Journal Title
  
  Liver Int 25
  
  Pages: 162-170
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] Effects of plasma from patients with hepatic failure on function of primary rat hepatocytes in three dimensional culture.2005
- Author(s)
  Nagaki M
- Journal Title
  
  Liver Int 25
  
  Pages: 1010-1017
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] The GH study Group. Prospective study on early virologic response to treatment with Interferon alpha-2b plus rebavirin in patients with chronic hepatitis C genotype 1b.2005
- Author(s)
  Nagaki M
- Journal Title
  
  Hepatol Res 33
  
  Pages: 285-291
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] Normal liver regeneration and liver cell apoptosis after partial hepatectomy in tumor necrosis factor-alpha-deficient mice2005
- Author(s)
  Hayashi H, Nagaki M, Imose M, Osawa Y, Kimura K, Takai S, Imao M, Naiki T, Kato T, Moriwaki H.
- Journal Title
  
  Liver Int 25(1)
  
  Pages: 162-70
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Journal Article] Adenovirus-mediated hepatocyte nuclear factor-4α overexpression maintains liver phenotype in cultured rat heptocytes.2005
- Author(s)
  Naiki T, Nagaki M, Asano T, Kimata T, Moriwaki H.
- Journal Title
  
  Biochem Biophys Res Commun 335
  
  Pages: 496-500
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] Prospective study on early virologic response to treatment with interferon alpha-2b plus rebavirin in patients with chronic hepatitis C genotype 1b.2005
- Author(s)
  Nagaki M, Imose M, Naiki T, Kimura K, Hayashi H, Shimizu M, Ohnishi H, Tomita E, Sugihara J, Amano K, Sakai T, Kojima T, Katsumura N, Kondo Y, Fujimoto M, Moriwaki H, the GH Study Group.
- Journal Title
  
  Hepatol Res 33
  
  Pages: 285-291
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] Psychoneurological symptoms during interferon therapy in patients with chronic hepatitis : prospective study on predictive use of Cornell medical index and EEG.2004
- Author(s)
  Tanaka Y, Nagaki M, Tomita E, Murase M, Enya M, Nishigaki Y, Sugihara J, Moriwaki H.
- Journal Title
  
  Liver Int 24
  
  Pages: 407-412
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] Functional activity of human hepatoma cells transfected with adenovirus-mediated hepatocyte nuclear factor (HNF)-4 gene.2004
- Author(s)
  Naiki T, Nagaki M, Shidoji Y, Kojima H, Moriwaki H.
- Journal Title
  
  Cell Transplant 13
  
  Pages: 393-403
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] Pivotal role of nuclear factor-κB signaling in anti-CD40-induced liver injury in mice.2004
- Author(s)
  Kimura K, Nagaki M, Takai S, Moriwaki H.
- Journal Title
  
  Hepatology 40
  
  Pages: 1180-1189
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] Leflunomide protects from T cell-mediated liver injury in mice through inhibition of nuclear factor κB.2004
- Author(s)
  Imose M, Nagaki M, Kimura K, Takai S, Imao M, Naiki T, Osawa Y, Asano T, Hayashi H, Moriwaki H.
- Journal Title
  
  Hepatology 40
  
  Pages: 1160-1169
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] Expression of the NF-κB target gene x-ray-inducible immediate early response factor-1 short enhances TNF-α-induced hepatocyte apoptosis by inhibiting Akt activation.2003
- Author(s)
  Osawa Y, Nagaki M, Banno Y, Brenner DA, Nozawa Y, Moriwaki H, Nakashima S.
- Journal Title
  
  J Immunol 170
  
  Pages: 4053-4060
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] Inhibition of nuclear factor-κB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor α in mice.2003
- Author(s)
  Imose M, Nagaki M, Naiki T, Osawa Y, Brenner DA, Asano T, Hayashi H, Kato T, Moriwaki H.
- Journal Title
  
  Liver Int 23
  
  Pages: 386-396
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] How are hepatocytes sensitized to apoptosis?2002
- Author(s)
  Nagaki M
- Journal Title
  
  J Gastroenterol 37
  
  Pages: 1094-1096
- NAID
  10013893977
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] TNF-α-induced IL-8 production via NF-κB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes.2002
- Author(s)
  Osawa Y, Nagaki M, Banno Y, Brenner DA, Takahiko Asano, Nozawa Y, Moriwaki H, Nakashima S.
- Journal Title
  
  Infect Immun 70
  
  Pages: 6294-6301
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] How are hepatocytes sensitized to apoptosis?.2002
- Author(s)
  Nagaki M, Moriwaki H.
- Journal Title
  
  J Gastroenterol 37
  
  Pages: 1094-1096
- NAID
  10013893977
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] Analysis of gene expression profile induced by hepatocyte nuclear factor 4α in hepatoma cells using an oligonucleotide microarray.2002
- Author(s)
  Naiki T, Nagaki M, Shidoji Y, Kojima H, Imose M, Kato T, Ohishi N, Yagi K, Moriwaki H.
- Journal Title
  
  J Biol Chem 277
  
  Pages: 14011-14019
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Journal Article] Staphylococcal enterotoxin B induces hepatic injury and lethal shock in endotoxin-resistent C3H/HeJ mice despite a deficient macrophage response.2002
- Author(s)
  Yasuda S, Nagaki M, Moriwaki H.
- Journal Title
  
  J Endotoxin Res 8
  
  Pages: 253-261
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590636
[Presentation] Inhibition of acid sphingomyelinase causes hepatic glucose into lerance and insulin resistance.2010
- Author(s)
  Osawa Y, Ito H, Suetsugu A, Nagaki M, Moriwaki H, Seishima M.
- Organizer
  Digestive Disease Week (DDW) 2010
- Place of Presentation
  ニューオリンズ
- Year and Date
  2010-05-03
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] 肝不全の病態と診療コンセプト2010
- Author(s)
  永木正仁
- Organizer
  肝炎医療従事者等研修会
- Place of Presentation
  松本
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] Free Paper Session「Basic aspects of inflammation and fibrosis in the liver and pancreas」Toll-like receptors induce lethal hepatic inflammation in D-galactosaminesensitized mice.2010
- Author(s)
  塚田良彦, 永木正仁, 末次淳, 大澤陽介, 木村公則, 森脇久隆
- Organizer
  The 18th United European Gastroenterology Week(UEGW)
- Place of Presentation
  バルセロナ
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] ハルァィスッソヨン「肝臓の再生機構を考える:今後の肝再生医療への展望」肝細胞死と肝再生・肝線維化連携機構におけるKupffer細胞め役割2010
- Author(s)
  大澤陽介、永木正仁、森脇久隆
- Organizer
  JDDW2010(第14回日本肝臓学会大会)
- Place of Presentation
  横浜
- Year and Date
  2010-10-13
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] シンポジウム「急性肝不全新規治療法の開発とその課題」基調講演「急性肝不全の病態と肝再生療法」2010
- Author(s)
  永木正仁、武藤泰敏、森脇久隆
- Organizer
  第36回日本急性肝不全研究会
- Place of Presentation
  山形
- Year and Date
  2010-05-26
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] HCV抗体陽性stageI肝細胞癌のラジオ波焼灼術による根治術後の再発リスクとインスリン抵抗性の関連についての検討2010
- Author(s)
  今井健二、高井光治、大西絋太郎、岩砂淳平、白木亮、内木隆文、清水雅仁、永木正仁、森脇久隆
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] Basic Science Workshop 「Pattern recognition receptor signalling」 Toll-like receptors induce lethal hepatic inflammation in D-galactosamine-sensitized mice.2010
- Author(s)
  Tsukada Y, Nagaki M, Suetsugu A, Osawa Y, Kimura K, Moriwaki H.
- Organizer
  The 18th United European Gastroenterology Week (UEGW)
- Place of Presentation
  バルセロナ
- Year and Date
  2010-10-25
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] C型代償性肝硬変におけるIFN-RBV併用療法の治療効果と予後の検討2010
- Author(s)
  内木隆文、永木正仁、清水雅仁、高井光治、白木亮、今井健二、岩砂淳平、大西紘太郎、大澤陽介、森脇久隆
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] 肝不全の病態解明と再生医療2010
- Author(s)
  永木正仁
- Organizer
  BISKET多施設共同研究検討会
- Place of Presentation
  佐賀
- Year and Date
  2010-08-30
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] 肝障害誘導におけるToll-like receptorの関与2010
- Author(s)
  塚田良彦、永木正仁、末次淳、大澤陽介、木村公則、森脇久隆
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] 胆管結紮誘導性慢性肝障害モデルにおけるKupffer細胞の役割2010
- Author(s)
  大澤陽介、永木正仁、森脇久隆
- Organizer
  第21回The meeting of liver and Immunology
- Place of Presentation
  東京
- Year and Date
  2010-09-04
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] Inhibition of acid sphingomyelinase causes hepatic glucose intolerance and insulin resistance.2010
- Author(s)
  Osawa Y, Ito H, Suetsugu A, Nagaki M, Moriwaki H, Seishima M.
- Organizer
  Digestive Disease Week (DDW)
- Place of Presentation
  ニューオリンズ
- Year and Date
  2010-05-03
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] 肝硬変患者の自覚症状・QOL(Quality of life)についての検討2010
- Author(s)
  白木亮、寺倉陽一、岩砂淳平、今井健二、高井光治、内木隆文、永木正仁、森脇久隆
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] Basic Science Workshop「Pattern recognition receptor signalling」 Toll-like receptors induce lethal hepatic inflammation in D-galactosamine-sensitized mice.2010
- Author(s)
  塚田良彦, 永木正仁, 末次淳, 大澤陽介, 木村公則, 森脇久隆
- Organizer
  The 18th United European Gastroenterology Week(UEGW)
- Place of Presentation
  バルセロナ
- Year and Date
  2010-10-25
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] パネルディスカッション「肝臓の再生機構を考える:今後の肝再生医療への展望」肝細胞死と肝再生・肝線維化連携機構におけるKupffer細胞の役割.2010
- Author(s)
  大澤陽介、永木正仁、森脇久隆
- Organizer
  JDDW2010(第14回日本肝臓学会大会)
- Place of Presentation
  横浜
- Year and Date
  2010-10-13
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] Free Paper Session 「Basic aspects of inflammation and fibrosis in the liver and pancreas」 Toll-like receptors induce lethal hepatic inflammation in D-galactosamine-sensitized mice.2010
- Author(s)
  Tsukada Y, Nagaki M, Suetsugu A, Osawa Y, Kimura K, Moriwaki H.
- Organizer
  The 18th United European Gastroenterology Week (UEGW)
- Place of Presentation
  バルセロナ
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] Role of CD44 in chemical induced liver injury2010
- Author(s)
  Kiminori Kimura, Masahito Nagaki
- Organizer
  EASL topic conference
- Place of Presentation
  Amsterdam
- Year and Date
  2010-02-18
- Data Source
  KAKENHI-PROJECT-20390203
[Presentation] シンポジウム「肝炎劇症化と肝再生不全:阻止は可能か?」G-CSFと肝再生不全:劇症肝炎亜急性モデルの確立2009
- Author(s)
  小木曽富生、永木正仁、高井信治、木村公則、森脇久隆
- Organizer
  第35回日本急性肝不全研究会
- Place of Presentation
  神戸
- Year and Date
  2009-06-03
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] 前駆細胞移植における細胞生存および分化に対する細胞外マトリックスの重要性2009
- Author(s)
  塚田良彦、永木正仁、末次淳、大澤陽介、森脇久隆
- Organizer
  DDW2009(第13回日本肝臓学会大会)
- Place of Presentation
  京都
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] ワークショップ3「免疫担当細胞異常からみた肝疾患の動態」胆管結紮誘導性慢性肝障害マウスモデルにおけるKupffer細胞の役割.2009
- Author(s)
  大澤陽介、永木正仁、森脇久隆
- Organizer
  JDDW2009(第13回日本肝臓学会大会)
- Place of Presentation
  京都
- Year and Date
  2009-10-14
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] シンポジウム「臨床応用をめざした肝細胞研究の展開」細胞外マトリックスによる肝細胞分化機構の解明と肝再生療法への応用2009
- Author(s)
  永木正仁、木全崇之、塚田良彦、森脇久隆
- Organizer
  第16回肝細胞研究会
- Place of Presentation
  山形
- Year and Date
  2009-06-26
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] シンポジウム「肝炎劇症化と肝再生不全:阻止は可能か?」G-CSF と肝再生不全:劇症肝炎亜急性モデルの確立2009
- Author(s)
  小木曽富生、永木正仁、高井信治、木村公則、森脇久隆
- Organizer
  第35回日本急性肝不全研究会
- Place of Presentation
  神戸
- Year and Date
  2009-06-03
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] ワークショップ3「免疫担当細胞異常からみた肝疾患の動態」胆管結紮誘導性慢性肝障害マウスモデルにおけるKupffer細胞の役割2009
- Author(s)
  大澤陽介、永木正仁、森脇久隆
- Organizer
  JDDW2009(第13回日本肝臓学会大会)
- Place of Presentation
  京都
- Year and Date
  2009-10-14
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] シンポジウム「肝幹細胞の分化・増殖と再生のメカニズム」肝幹/前駆細の分化誘導と肝再生療法への応用2009
- Author(s)
  永木正仁、末次淳、小木曽富生、森脇久隆
- Organizer
  第16回肝細胞研究会
- Place of Presentation
  山形
- Year and Date
  2009-06-27
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] 肝前駆細胞移植における細胞生存および分化に対する細胞外マトリックスの重要性2009
- Author(s)
  塚田良彦、永木正仁、末次淳、大澤陽介、森脇久隆
- Organizer
  JDDW2009(第13回日本肝臓学会大会)
- Place of Presentation
  京都
- Year and Date
  2009-10-05
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] 胆管結紮誘導性慢性肝障害モデルにおける肝細胞抗アポトーシス獲得機序の検討2009
- Author(s)
  大澤陽介、永木正仁、伊藤弘康、清島満、森脇久隆
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] Critical role of CD44 in Hepatotoxin mediated liver injury2008
- Author(s)
  Kiminori Kimura, Masahito nagaki, Kazuhiro Kakimi, Hisataka Moriwaki
- Organizer
  AASLD
- Place of Presentation
  Boston, USA
- Year and Date
  2008-11-05
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Presentation] ワークショップ「肝障害と修復に関する研究の展開」HNF-4遺伝子導入による肝前駆細胞の分化誘導と細胞療法への応用2008
- Author(s)
  末次淳、永木正仁、森脇久隆
- Organizer
  第44回日本肝臓学会総会
- Place of Presentation
  松山
- Year and Date
  2008-06-06
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] Interacion of CTLs and CD44 in acute hepatitis model using hepatitis B virus transgenic mice.2008
- Author(s)
  木村公則, 永木正仁, 森脇久隆, 垣見和宏
- Organizer
  The 59th Annual Meeting of the American Association for the Study of the Liver Diseases.
- Place of Presentation
  サンフランシスコ
- Year and Date
  2008-11-03
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] B型急性肝炎モデルにおけるThioredoxin-1の関与2008
- Author(s)
  木村公則、永木正仁
- Organizer
  日本肝臓学会東部会シンポジウム
- Place of Presentation
  東京
- Year and Date
  2008-12-04
- Data Source
  KAKENHI-PROJECT-20390203
[Presentation] In Parallel Session 「Animal Models of Cell Transplantation and Acute Liver Failure」 Granulocyte colony-stimulating factor induces subacute liver failure that shows impaired liver regeneration and high mortality in mice through the up-regulation of interleukin-1β.2008
- Author(s)
  永木正仁, 小木曽富生, 高井信治, 木村公則, 森脇久隆
- Organizer
  The 59th Annual Meeting of the American Association for the Study of the Liver Diseases.
- Place of Presentation
  サンフランシスコ
- Year and Date
  2008-11-02
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] Granulocyte colony-stimulating factor induces subacute liver failure that shows impaired liver regeneration and high mortality in mice through the up-regulation of interleukin-1B2008
- Author(s)
  Nagaki M
- Organizer
  The 59th Annual Meeting of the American Association for the Study of the Liver Diseases.
- Place of Presentation
  アメリカサンフランシスコ
- Year and Date
  2008-11-02
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] ラット2-AAF投与後部分肝切除モデル(modified Solt-Farber model)におけるHNF-4遺伝子導入における肝細胞分化誘導の検討2008
- Author(s)
  小木曽富生、永木正仁、塚田良彦、末次淳、大澤陽介、森脇久隆
- Organizer
  第12回日本肝臓学会大会
- Place of Presentation
  東京
- Year and Date
  2008-10-02
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] ワークショップ「肝炎ウイルス感染・複製・排除のメカニズム」B 型肝炎トランスジェニックマウスを用いた急性肝炎モデルにおけるCTLとCD44の相互作用2008
- Author(s)
  木村公則、永木正仁、森脇久隆、垣見和宏
- Organizer
  第44回日本肝臓学会総会
- Place of Presentation
  松山
- Year and Date
  2008-06-06
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] B型肝炎治療における自然免疫制御の有用性2008
- Author(s)
  木村公則、永木正仁
- Organizer
  日本肝臓学会シンポジウム
- Place of Presentation
  東京
- Year and Date
  2008-10-02
- Data Source
  KAKENHI-PROJECT-20390203
[Presentation] シンポジウム「B型肝炎の今日的標準治療と理想的近未来治療への挑戦」B型肝炎治療における自然免疫制御の有用性2008
- Author(s)
  木村公則、永木正仁、垣見和宏
- Organizer
  第12回日本肝臓学会大会
- Place of Presentation
  東京
- Year and Date
  2008-10-02
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] シンポジウム「Hepatic stem cell と cancer stem cell」肝幹細胞におけるHNF-4の役割と癌幹細胞におけるCD133陽性細胞の特徴2008
- Author(s)
  末次淳、永木正仁、森脇久隆
- Organizer
  第12回日本肝臓学会大会
- Place of Presentation
  東京
- Year and Date
  2008-10-01
- Data Source
  KAKENHI-PROJECT-20590770
[Presentation] 四塩化炭素を用いた肝障害モデルにおけるCD44の役割2007
- Author(s)
  木村公則、永木正仁、垣見和宏、森脇久隆
- Organizer
  日本肝臓学会
- Place of Presentation
  大阪
- Year and Date
  2007-03-06
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590628
[Presentation] Crucial role of CD44 in liver injury2007
- Author(s)
  kiminori kimura, Masahito nagaki, Kazuhiro Kakimi, Toshinori Nakayama, Masaru Taniguchi and Hisataka Moriwaki
- Organizer
  AAI
- Place of Presentation
  San Diego, USA
- Year and Date
  2007-04-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590628

1. KIMURA Kiminori (70397339)

# of Collaborated Projects: 3 results

# of Collaborated Products: 36 results
2. MORIWAKI Hisataka (50174470)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
3. KAKIMI Kazuhiro (80273358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. SAIO Masanao (40242721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KURACHI Makoto (00396722)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. UEHA Satoshi (00447385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MATSUSHIMA Kouji (50222427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OSAWA Yosuke (60447787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 29 results
9. KOJIMA Hisanori (80270552)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SHIDOJI Yoshihiro (00111518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NAIKI Takafumi (80402197)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
12. MIYAGISHI Makoto (30323538)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 末次淳 (30340079)

# of Collaborated Projects: 1 results

# of Collaborated Products: 24 results
14. 大西弘生 (40176954)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 林秀樹

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 齊尾征直

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

NAGAKI Masahito 永木 正仁

Research Projects

Research Products

Co-Researchers

Development of the novel therapeutic vaccine using persistent viral hepatitis infection model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analysis of inflammatory cascade between antigen specific CTLs and liver injury using hepatitis model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of regenerative medicine and therapeutic system for hepatic failure applied by hepatocyte nuclear factor 4Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study of anti-hepatitis B virus drugs using RNA technology

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

STUDIES ON DIFFERENTIATION AND REGENERATION OF FETAL LIVER STEM CELLS AND THEIR APPLICATION FOR HEPATIC FAILUREPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DEVELOPMENT OF BIOARTIFICIAL LIVERPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Role of interleukin-18 in intrahepatic inflammatory cells recruitment in acute liver injury.2011

Author(s)

Journal Title

Data Source

[Journal Article] Imaging the recruitment of cancer-associated fibroblasts by liver-metastatic colon cancer.2011

Author(s)

Journal Title

Data Source

[Journal Article] Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression.2011

Author(s)

Journal Title

Data Source

[Journal Article] Role of interleukin-18 in intrahepatic inflammatory cells recruitment in acute liver injury.2011

Author(s)

Journal Title

Data Source

[Journal Article] Role of interleukin-18 in intrahepatic inflammatory cell recruitment in acute liver injury.2011

Author(s)

Journal Title

Data Source

[Journal Article] Role of interleukin-18 in intrahepatic inflammatory cell recruitment in acute liver injury.2011

Author(s)

Journal Title

Data Source

[Journal Article] Role of interleukin-18 in intrahepatic inflammatory cell recruitment in acute liver injury2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression.2011

Author(s)

Journal Title

Data Source

[Journal Article] Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression.2011

Author(s)

Journal Title

Data Source

[Journal Article] Is there a delayed gastric emptying of patients with early-stage, untreated Parkinson's disease? An analysis using the 13C-acetate breath test.2011

Author(s)

Journal Title

NAGAKI Masahito 永木正仁