Shimizu Hiroki 清水弘樹

… Alternative Names

SHIMIZU HIROKI 清水弘樹

SHIMIZU Hiroki 清水弘樹

清水弘樹シミズヒロキ

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Researcher Number	30344716
Affiliation (Current)	2025: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員
Affiliation (based on the past Project Information) *help	2018 – 2021: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 2017: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 2016: 国立研究開発法人産業技術総合研究所, その他部局等, 研究員 2015 – 2016: 国立研究開発法人産業技術総合研究所, 生物プロセス部門, 研究員 2014 – 2016: 国立研究開発法人産業技術総合研究所, 生物プロセス研究部門, 主任研究員 … More 2014: 独立行政法人産業技術総合研究所, 生物プロセス部門, 主任研究員 2011 – 2014: 独立行政法人産業技術総合研究所, 生物プロセス研究部門, 主任研究員 2007 – 2008: 独立法人産業技術総合研究所, 創薬シーズ探索ラボ, 研究員 2006 – 2007: 独立行政法人産業技術総合研究所, 創薬シーズ探索研究ラボ, 研究員 2004: 独立行政法人, 産業技術総合研究所・北海道センター, 研究員 Less
Review Section/Research Field	Principal Investigator Bioproduction chemistry/Bioorganic chemistry / Laboratory medicine / Applied molecular and cellular biology Except Principal Investigator Bioproduction chemistry/Bioorganic chemistry / Basic Section 43020:Structural biochemistry-related / Hygiene and public health / Green/Environmental chemistry / Bio-related chemistry / Applied molecular and cellular biology
Keywords	Principal Investigator 糖鎖 / 糖ペプチド / マイクロ波 / 有機化学 / Glycopeptide / Electromagnetic Wave / Green Chemistry / Microwave / Organic Chemistry / Oligosaccharide … More / 電磁波 / グリーンケミストリー / C型肝炎 / 糖 / 抗体 / Ｃ型肝炎 / 酵素反応 / 有機合成 / シクロデキストリン / タンパク質・糖鎖工学 … More Except Principal Investigator 化学合成 / 特異性変換 / 結合強化 / 立体構造解析 / 非天然アミノ酸 / 変異導入 / 立体構造 / タンパク質認識 / 糖鎖認識 / レクチン / 抗カビシステム / 菌類 / 酵素反応 / 機能性表面 / 抗カビシステム、 / 衛生 / Stereochemistry / Nuclear magnetic resonance / Insect pheromones / Fluorescence derivatization / High performance liquid chromatography / Enantiomeric discrimination / Chiral amines / Chiral alcohols / 分岐アルコール / 蛍光誘導体化試薬 / キラル誘導体化試薬 / 分岐アルキル / 光学活性化合物 / 蛍光誘導体化法 / 立体化学 / 核磁気共鳴スペクトル / 昆虫フェロモン / 蛍光誘導体化 / 高速液体クロマトグラフィー / 不斉識別 / 光学活性アミン / 光学活性アルコール / 二酸化炭素 / 水 / バイオマス / サスティナブルケミストリー / 水熱反応 / 加水分解反応 / 超臨界二酸化炭素 / 化学原料化 / 木質系バイオマス / 糖ペプチド / マイクロ波 / ヒアルロン酸 / ムチン / 立体選択的グリコシル化 / 有機合成 / 小胞体膜 / デタージェント / 等温滴定型熱量計 / 臨界ミセル濃度 / フッ素 / 糖鎖合成 / 膜タンパク質 / 糖 / 界面活性剤 / NMR / 動力学計算 / 熱化学実験 / 安定誘導体の合成 / 多糖 / 酵素反応遷移状態配座 / エンド型グリコシダーゼ / 遷移状態アナログ / 硫黄置換誘導体 / 基質アナログ / エンドポリガラクツロナーゼ / セルラーゼ / エンドグリコシダーゼ / 複合体形成 / 基質ミミック / 反応機構 / endo型グリコシダーゼ Less

Development of novel probes for a glycan for medicinal technology
- Principal Investigator
  
  Yamasaki Kazuhiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Development of auto-release system of non-toxic anti-fungal compounds triggered by enzymes produced by fungus itself.
- Principal Investigator
  
  Yamaguchi Munehiro
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hygiene and public health
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Discovery and application of frequency dependence of microwave-assisted degradation of mucin
- Principal Investigator
  
  KAMEYAMA AKIHIKO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bio-related chemistry
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Hydrolysis of lignocellulosic biomass with supercritical CO2
- Principal Investigator
  
  SASAKI Masahide
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Green/Environmental chemistry
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Synthesis of a novel glyco-detergent for analysis of membrane protein
- Principal Investigator
  
  Matsuo Ichiro
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Gunma University
Research of neutralizing antibody recognizing glycopeptides onto hepatitis C virus and basic studies for new diagnosesPrincipal Investigator
- Principal Investigator
  
  Shimizu Hiroki
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Synthetic studies of unnatural beta1-4galactosyl cyclodextrinsPrincipal Investigator
- Principal Investigator
  
  SHIMIZU HIROKI
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  National Institute of Advanced Industrial Science and Technology
A reaction mechanism elucidation study based on many sugar-endo Type glycosidase complex analysi
- Principal Investigator
  
  HASHIMOTO Masaru
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Hirosaki University
Study of Microwave Effects for Syntheses of Oligosaccharides and GlycopeptidesPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Hiroki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Highly sensitive enantiomeric discrimination of chiral branched alkyl chains of fatty alcohols and amines, and the application to determine absolute stereochemistry of natural occurring products
- Principal Investigator
  
  AKASAKA Kazuaki
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Tohoku University

[Book] マイクロ波加熱の基礎と産業応用（第５章第２節「マイクロ波照射による糖鎖・糖ペプチド合成」）2017
- Author(s)
  清水弘樹
- Publisher
  R&D支援センター
- Data Source
  KAKENHI-PROJECT-26620142
[Book] 糖鎖の新機能開発応用ハンドブック、第4編第1章 4-4 マイクロ波合成2015
- Author(s)
  長島生、清水弘樹
- Publisher
  （株）エヌ・ティー・エス
- Data Source
  KAKENHI-PROJECT-25293134
[Book] 最新マイクロ波エネルギーと応用技術、第5章 5-3 生体高分子合成 (糖鎖、ペプチド、糖ペプチド)2014
- Author(s)
  長島生、清水弘樹
- Publisher
  ㈱産業技術サービスセンター
- Data Source
  KAKENHI-PROJECT-25293134
[Journal Article] Structural Basis for Specific Recognition of Core Fucosylation in N-glycans by Pholiota Squarrosa Lectin (PhoSL)2019
- Author(s)
  Kazuhiko Yamasaki, Tomomi Kubota, Tomoko Yamasaki, Izuru Nagashima, Hiroki Shimizu, Ryu-Ichiro Terada, Hiroshi Nishigami, Jiyoung Kang, Masaru Tateno, Hiroaki Tateno
- Journal Title
  
  Glycobiology
  
  Volume: 29 Issue: 7 Pages: 576-587
- DOI
  10.1093/glycob/cwz025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02397
[Journal Article] Studies of Cyclodextrin Effect for Glycosylation by Galactosyltransferase2014
- Author(s)
  NAGASHIMA, Izuru; SHIMIZU, Hiroki
- Journal Title
  
  Tetrahedron
  
  Volume: vol.70, No.19 Issue: 19 Pages: 3146-3154
- DOI
  10.1016/j.tet.2014.03.058
- Data Source
  KAKENHI-PROJECT-23658293
[Journal Article] Efficiency of 2.45 and 5.80 GHz microwave irradiation for a hydrolysis reaction by thermostable beta-Glucosidase HT12014
- Author(s)
  Nagashima, Izuru; Sugiyama, Jun-ichi; Sakuta, Tomomi; Sasaki, Masahide; Shimizu, Hiroki
- Journal Title
  
  Biosci. Biotechnol. Biochem.,
  
  Volume: 78 Issue: 5 Pages: 758-760
- DOI
  10.1080/09168451.2014.891931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293134
[Journal Article] Expression, purify- cation and analyses of glycosylation and disulfide bonds of Stereum purpureu endopolygalacturonase I in Pichia pastoris2009
- Author(s)
  S. Ogawa, T. Shimizu, H. Ohki, T. Araya, T. Okuno, K. Miyairi
- Journal Title
  
  Protein Expression and Purification 65
  
  Pages: 15-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380064
[Journal Article] Expression, purification and analyses of glycosylation and disulfide bonds of Stereum purpureum endopolygalacturonase I in Pichia pastoris2009
- Author(s)
  S. Ogawa, T. Shimizu, H. Ohki, T. Araya, T. Okuno, K. Mivairi
- Journal Title
  
  Protein Expression and Purification 65
  
  Pages: 15-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380064
[Journal Article] Practical Study of Nonthermal Microwave Effects Applying to Oligosaccharide Synthesis2008
- Author(s)
  Hiroki Shimizu, et. al.
- Journal Title
  
  Journal of Microwave Power and Electromagnetic Energy (in press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580109
[Journal Article] New glycosylation method Part III : Study of microwave effects at low temperatures to control reaction pathways and reduce byproducts2008
- Author(s)
  H. Shimizu, Y. Yoshimura, H. Hinou ; S. -I. Nishimura
- Journal Title
  
  Tetrahedron 64
  
  Pages: 10091-10096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380064
[Journal Article] Synthesis of D-trigalacturonic acid methylglycoside2008
- Author(s)
  Yamamoto, K., Sato, Y., Ishimori, A., Miyairi, K., Okuno, T., Nemoto, N.,Shimizu, H., Kidokoro, S., Hashimoto, M.
- Journal Title
  
  Biosci. Biotech. Biochem 71
  
  Pages: 1230-1235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380064
[Journal Article] Chemical and enzymatic synthesis of neoglycolipids in the presence of cvclodextrins2008
- Author(s)
  I. Nagashima, H. Shimizu, T. Matsushita, S. -I. Nishimura
- Journal Title
  
  Tetrahedron Letters 49
  
  Pages: 3413-3418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380064
[Journal Article] Expression, purification, and analyses of glycosylation and disulfide bonds of Stereum purpreum endopolygalacturonase I in Pichia pastoris2008
- Author(s)
  Ogawa, S., Shimizu, T., Ohki, H., Araya, T., Okuno, T., Miyairi, K.
- Journal Title
  
  Protein Expression and Purification 65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380064
[Journal Article] Synthesis of D-trigalacturonic acid methylglycoside2008
- Author(s)
  Yamamoto, K., Sato, Y., Ishimori, A., Miyairi, K., Okuno, T., Nemoto, N., Shimizu, H., Kidokoro, S., Hashimoto, M
- Journal Title
  
  Biosci. Biotech. Biochem 72(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380064
[Journal Article] Synthesis of D-trigalacturonic acid methylglycoside2008
- Author(s)
  Yamamoto, K., Sato, Y., Ishimori, A., Miyairi, K., Okuno, T., Nemoto, N., Shimizu, H.,Kidnknro. S., Hashimoto. M.
- Journal Title
  
  Biosci. Biotech. Biochem 71
  
  Pages: 1230-1235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380064
[Journal Article] Chemical and enzymatic synthesis of neoglycolipids in the presence of cyclodextrins2008
- Author(s)
  Nagashima I.,Shimizu H., et.al.
- Journal Title
  
  Tetrahedron Letters 49
  
  Pages: 3413-3418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380064
[Journal Article] New glycosylation method Part III : Study of microwave effects at low temperatures to control reaction pathways and reduce byproductsq2008
- Author(s)
  H. Shimizu, et.al.
- Journal Title
  
  Tetrahedron 64
  
  Pages: 10091-10096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380064
[Journal Article] 結合の角度から分子の立体構造を決める、液晶NMR法2008
- Author(s)
  清水弘樹
- Journal Title
  
  化学と生物 46
  
  Pages: 648-652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380064
[Journal Article] A New Glycosylation Method Part III: Study of Microwave Effects at Low Temperatures as Controlling Reaction Pathways and Reducing Byproducts2008
- Author(s)
  Hiroki Shimizu, et. al.
- Journal Title
  
  Tetrahedron (submitted)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580109
[Journal Article] マイクロ波を利用した糖鎖・糖ペプチド精密合成2007
- Author(s)
  清水弘樹, 等
- Journal Title
  
  高分子論文集 64
  
  Pages: 883-896
- NAID
  10020027833
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580109
[Journal Article] Microwave chemistry for glycosylation and oligopeptide synthesis2007
- Author(s)
  Hiroki Shimizu, et. al.
- Journal Title
  
  Japanese Journal of Polymer Science and Technology 64
  
  Pages: 883-896
- NAID
  10020027833
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580109
[Journal Article] A New Glycosylation Method Part II ; Study of Carbohydrate Elongation onto the Gold Nanoparticles in a Colloidal Phase2007
- Author(s)
  Shimizu, Hiroki, Sakamoto, Masahiro, Nagahori, Noriko, Shin-Ichiro Nishimura
- Journal Title
  
  Tetrahedron 63
  
  Pages: 2418-2425
- Data Source
  KAKENHI-PROJECT-18580109
[Journal Article] マイクロ波を利用した糖鎖・糖ペプチド精密合成2007
- Author(s)
  清水弘樹等
- Journal Title
  
  高分子論文集 64
  
  Pages: 883-896
- NAID
  10020027833
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580109
[Journal Article] A New Glycosylation Method Part II ; Study of Carbohydrate Elongation onto the Gold Nanoparticles in a Colloidal Phase2007
- Author(s)
  Hiroki Shimizu, et. al.
- Journal Title
  
  Tetrahedron 63
  
  Pages: 2418-2425
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580109
[Journal Article] A New Glycosylation Method Part II; Study of Carbohydrate Elongation onto the Gold Nanoparticles in a Colloidal Phase2007
- Author(s)
  Hiroki Shimizu, et. al.
- Journal Title
  
  Tetrahedron 63
  
  Pages: 2418-2425
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580109
[Journal Article] Construction of Highly Glycosylated Mucin-Type Glycopeptides Based on Microwave-Assisted Solid-phase Syntheses and Enzymatic Modifications2006
- Author(s)
  Matsushita, Takahiko, Hinou, Hiroshi, Fumoto, Masataka, Kurogouchi, Masaki, Fujitani, Naoki, Shimizu, Hiroki, Nishimura, Shin-Ichiro
- Journal Title
  
  The Journal of Organic Chemistry 71・8
  
  Pages: 3051-3063
- Data Source
  KAKENHI-PROJECT-18580109
[Journal Article] Construction and Structural Characterization of Versatile Lactosaminoglycan-Related Compound Library for the Synthesis of Complex Glycopeptides and Glycosphingolipids2006
- Author(s)
  Naruchi, Kentarou, Hamamoto, Tomoki, Kurogochi, Masaki, Hinou, Hiroshi, Shimizu, Hiroki, Matsushita, Takahiko, Fujitani, Naoki, Kondo, Hirosato, Nishimura, Shin-Ichiro
- Journal Title
  
  The Journal of Organic Chemistry 71・26
  
  Pages: 9609-9621
- Data Source
  KAKENHI-PROJECT-18580109
[Journal Article] Construction of MUC1 Related Compound Librar2006
- Author(s)
  Ohyabu, Naoki, Matsushita, Takahiko, Hinou, Hiroshi, Izumi, Ryukou Shimizu, Hiroki Kondo, Hirosato Shin-Ichiro Nishimura
- Journal Title
  
  Glycobiology 16
  
  Pages: 1152-1152
- Data Source
  KAKENHI-PROJECT-18580109
[Journal Article] Development of Highly Potent D-Glucosamine-Based Chiral Fluorescent Labeling Reagents and a Microwave-Assisted β-Selective Glycosidation of a Methyl Glycoside Reagent,2005
- Author(s)
  Hiroshi Ohrui, Rumiko Katoh, Teruhisa Kodaira, Hiroki Shimizu, Kazuaki Akasaka, Takeshi Kitahara
- Journal Title
  
  Bioscience, Biotechnology and Boichemistry 69(5)
  
  Pages: 1054-1057
- NAID
  130000030345
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16380076
[Journal Article] Practical Study of Nonthermal Microwave Effects Applying to Oligosaccharide Synthesis
- Author(s)
  Hiroki Shimizu, et. al.
- Journal Title
  
  Journal of Microwave Power and Electromagnetic Energy (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580109
[Journal Article] A New Glycosylation Method Part III ; Study of Microwave Effects at Low Temperatures as Controlling Reaction Pathways and Reducing Byproducts
- Author(s)
  Hiroki Shimizu, et. al.
- Journal Title
  
  Tetrahedron (submittes)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580109
[Patent] スギタケレクチン及び/又はその変異ペプチドを含むウイルス感染症の治療用又は診断用医薬組成物2024
- Inventor(s)
  山崎和彦、舘野浩章、清水弘樹、森田公一、ヌグエトン, ミャミャッ
- Industrial Property Rights Holder
  国立研究開発法人産業技術総合研究所、国立大学法人長崎大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2024-512384
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-18H02397
[Patent] スギタケレクチン及び/又はその変異ペプチドを含むウイルス感染症の治療用又は診断用医薬組成物2023
- Inventor(s)
  山崎和彦、舘野浩章、清水弘樹、森田公一、NgweTun M.M.
- Industrial Property Rights Holder
  産業技術総合研究所、長崎大学
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-18H02397
[Patent] スギタケレクチン及び/又はその変異ペプチドを含むウイルス感染症の治療用又は診断用医薬組成物2022
- Inventor(s)
  山崎和彦, 舘野浩章, 清水弘樹, 森田公一, ミャミャッヌグエトン
- Industrial Property Rights Holder
  産業技術総合研究所長崎大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-052125
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-18H02397
[Presentation] マイクロ波が齎す化学反応への作用が見えてきた2018
- Author(s)
  清水弘樹
- Organizer
  平成30年度第58回GICセミナー
- Data Source
  KAKENHI-PROJECT-15K15247
[Presentation] マイクロ波を化学反応に利用する～加熱特性ではない特有の効果に迫る～2018
- Author(s)
  清水弘樹
- Organizer
  2018年度第1回HiNTセミナー
- Data Source
  KAKENHI-PROJECT-15K15247
[Presentation] 糖鎖基質酵素反応におけるマイクロ波効果の研究2016
- Author(s)
  長島生、作田智美、杉山順一、佐々木正秀、清水弘樹
- Organizer
  日本農芸化学会2016年大会
- Place of Presentation
  札幌コンベンションセンター（北海道）
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-25293134
[Presentation] 熱化学変換法による木質系バイオマスの糖化反応研究2016
- Author(s)
  藤中悠太、清水弘樹、佐々木正秀
- Organizer
  平成28年度日本農芸化学会　北海道支部第2回講演会
- Place of Presentation
  北海道大学農学部、札幌市
- Data Source
  KAKENHI-PROJECT-26620151
[Presentation] 化学反応におけるマイクロ波特性とマイクロ波効果の活用2015
- Author(s)
  清水弘樹
- Organizer
  化学工学会第47回秋季大会
- Place of Presentation
  北海道大学工学部（北海道）
- Year and Date
  2015-09-09
- Invited
- Data Source
  KAKENHI-PROJECT-25293134
[Presentation] マイクロ波を使用したペプチド固相合成法の必要条件の検討2015
- Author(s)
  山田隆哉、長島生、佐々木正秀、清水弘樹
- Organizer
  平成27年度日本農芸化学会北海道支部第２回講演会
- Place of Presentation
  北海道大学学術交流会館（北海道）
- Year and Date
  2015-11-14
- Data Source
  KAKENHI-PROJECT-25293134
[Presentation] beta-グルコース加水分解酵素反応における低周波マイクロ波効果の研究2015
- Author(s)
  長島生、杉山順一、清水弘樹
- Organizer
  日本農芸化学会2015年大会
- Place of Presentation
  岡山大学津島キャンパス（岡山県）
- Year and Date
  2015-03-29
- Data Source
  KAKENHI-PROJECT-25293134
[Presentation] 反応容器による酵素反応の反応性差異2015
- Author(s)
  清水弘樹、長島生
- Organizer
  バイオ分子科学研究会
- Place of Presentation
  慶応義塾大学日吉キャンパス（神奈川県）
- Year and Date
  2015-08-22
- Data Source
  KAKENHI-PROJECT-25293134
[Presentation] 耐熱グルコシダーゼHT1酵素反応におけるマイクロ波効果の研究2014
- Author(s)
  長島生、作田智美、杉山順一、佐々木正秀、清水弘樹
- Organizer
  日本農芸化学会2014年大会
- Place of Presentation
  明治大学（神奈川）
- Data Source
  KAKENHI-PROJECT-25293134
[Presentation] 熱化学変換法による木質系バイオマスの糖化2014
- Author(s)
  市原和幸、加我晴生、清水弘樹、佐々木正秀
- Organizer
  日本化学会北海道支部
- Place of Presentation
  苫小牧工業専門学校
- Year and Date
  2014-07-12
- Data Source
  KAKENHI-PROJECT-26620151
[Presentation] 糖加水分解酵素反応におけるマイクロ波の効果と作用機構解明研究2014
- Author(s)
  長島生、作田智美、杉山順一、清水弘樹
- Organizer
  第33回日本糖質学会年会
- Place of Presentation
  名古屋大学豊田講堂（愛知県）
- Year and Date
  2014-08-12
- Data Source
  KAKENHI-PROJECT-25293134
[Presentation] マイクロ波固相合成装置の開発と、ペプチド合成研究2009
- Author(s)
  清水弘樹
- Organizer
  日本農芸化学会2009年度
- Place of Presentation
  福岡
- Year and Date
  2009-03-29
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] リンゴ銀葉病菌由来エンドポリガラクツロナーゼIのC末端領域は自己の活性を阻害する2009
- Author(s)
  小川俊、宇藤憲則、大木肇、清水哲哉、奥野、宮入一夫
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] ペプチド固相反応適応型マイクロ波合成反応装置の開発と利用研究2009
- Author(s)
  清水弘樹、長島生、松下隆彦、西村紳一郎、為野強士、秋元正寿
- Organizer
  第43回高分子学会北海道支部研究発表会
- Place of Presentation
  札幌
- Year and Date
  2009-02-03
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] 難溶性糖脂質に対する糖転移酵素反応のシクロデキストリン効果Part22009
- Author(s)
  清水弘樹
- Organizer
  日本農芸化学会2009年度
- Place of Presentation
  福岡
- Year and Date
  2009-03-29
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] 環状不凍糖タンパク質の合成および不凍活性2009
- Author(s)
  清水弘樹, 他
- Organizer
  第43回高分子学会北海道支部研究発表会
- Place of Presentation
  札幌
- Year and Date
  2009-02-03
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] ペプチド固相反応適応合成および不凍活性2009
- Author(s)
  清水弘樹, 他
- Organizer
  第43回高分子学会北海道支部研究発表会
- Place of Presentation
  札幌
- Year and Date
  2009-02-03
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] リンゴ銀葉病菌由来エンドポリガラクツロナーゼ1のC末端領域は自己の活性を阻害する2009
- Author(s)
  小川俊、宇藤憲則、大木肇、清水哲哉、奥野智旦、宮入一夫
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] マイクロ波を用いたオリゴ糖効率合成研究2008
- Author(s)
  清水弘樹等
- Organizer
  第8回GSCシンポジウム
- Place of Presentation
  東京
- Year and Date
  2008-03-06
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580109
[Presentation] マイクロ波を活用した糖鎖・糖ペプチド合成研究2008
- Author(s)
  清水弘樹, 他
- Organizer
  第50回天然有機化合物討論会
- Place of Presentation
  福岡
- Year and Date
  2008-10-01
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] Cyclodextrin Effect for Syntheses Water-Insoluble Neo-Glycolipids2008
- Author(s)
  Hiroki Shimizu, et. al.
- Organizer
  Annual Meeting for JSBBA 2008
- Place of Presentation
  Nagoya
- Year and Date
  2008-03-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580109
[Presentation] Shutter-less continuous rotation data collection from protein crystals with the X-ray CMOS detector2008
- Author(s)
  Kazuya Hasegawa, Kunio hirata, Tetsuya Shimizu, Takashi Kumasaka, and Masaki Yamamoto
- Organizer
  第21回国際結晶学会議
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] リンゴ銀葉病菌由来Endopoly alacturonaseIの欠失C末端44残基の機能解析2008
- Author(s)
  小川俊, 大木肇, 清水哲哉, 奥野智旦, 宮入一夫
- Organizer
  日本応用糖質科学会2008年度大会
- Place of Presentation
  沖縄
- Year and Date
  2008-09-18
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] Cyclodextrin effects for synthesis of neoglycolipids by glycosyltransferases2008
- Author(s)
  H. Shimizu, I. Nagashima, T. Matsushita, S. -I. Nishimura
- Organizer
  24th International Carbohydrate Symposium
- Place of Presentation
  Oslo, Norway
- Year and Date
  2008-07-27
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] Manipulating Proteinmicrocrystal with optical tweezersbased on lensed fiber probes2008
- Author(s)
  Takaaki Hikima, Tetsuya Shimizu and Masaki Yamamoto
- Organizer
  第21回国際結晶学会議
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] 難溶性擬似糖脂質の水溶液中での酵素反応を可能とするシクロデキストリンの効果2008
- Author(s)
  清水弘樹、長島生、松下隆彦、西村紳一郎
- Organizer
  第28回日本糖質学会年会
- Place of Presentation
  つくば
- Year and Date
  2008-08-19
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] リンゴ銀葉病菌由来Endopolygalacturonase Iの欠失C末端44残基の機能解析2008
- Author(s)
  小川俊, 大木肇, 清水哲哉, 奥野智旦, 宮入一夫
- Organizer
  日本応用糖質科学会2008年度大会
- Place of Presentation
  沖縄
- Year and Date
  2008-09-18
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] 難溶性糖脂質に対する糖転移酵素反応のシクロデキストリン効果2008
- Author(s)
  清水弘樹等
- Organizer
  日本農芸化学会2008年度(平成20年度)大会
- Place of Presentation
  名古屋
- Year and Date
  2008-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580109
[Presentation] Practical study of nonthermal microwave effects applying to oligosaccharide syntheses2008
- Author(s)
  H. Shimizu, T. Matsushita, S. -I. Nishimura
- Organizer
  GCMEA 2008 MAJIC : 1st Global Conference on Microwave Energy Applications
- Place of Presentation
  Otsu Shiga, Japan
- Year and Date
  2008-08-06
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] Ultra-high resolution structure of endopolygalacturonase determined by X-rayand neutron diffraction2008
- Author(s)
  Tetsuya Shimizu, Toru Nakatsu, Nobutaka Shimizu, Mamoru Sato, Kauo Kurihara, Kazuo Miyairi, Toshikatsu Okuno, Nobuo Niimura, Hiroaki Kato
- Organizer
  第21回国際結晶学会議
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] 機能性食品開発や創薬を指向した糖鎖の応用-マイクロ波を利用した効率的合成法の開発を背景に-2008
- Author(s)
  清水弘樹, 他
- Organizer
  HiNTセミナー20085
- Place of Presentation
  札幌
- Year and Date
  2008-08-26
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] Ultra-high resolution structure of endolygalaturonase determined by X-ray and neutron diffraction2008
- Author(s)
  清水哲哉
- Organizer
  第21回国際結晶学会議
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] Effective Oligosaccharide Synthesis with Using Microwave Irradiation2008
- Author(s)
  Hiroki Shimizu, et. al.
- Organizer
  8th GSC Symposium
- Place of Presentation
  Yokyo
- Year and Date
  2008-03-06
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580109
[Presentation] ペプチド固相合成に特化させたマイクロ波利用合成装置の開発とその利用研究2008
- Author(s)
  清水弘樹, 他
- Organizer
  平成20年度第二回合同学術講演会
- Place of Presentation
  帯広
- Year and Date
  2008-11-09
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] Remodeling of Mouse Notch-1 Glycopeptide : Synthesis and Strue tural Characterization of Glycosylated Epidermar Growth Factor-Like Reneats 122008
- Author(s)
  K. H. Shimizu, N. Fujitani, H. Shimizu, S. -I. Nishimura
- Organizer
  24th International Carbohydrate Symposium
- Place of Presentation
  Oslo, Norway
- Year and Date
  2008-07-31
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] 機能性食品開発や創薬を指向した糖鎖の応用-マイクロ波を利用した効率的合成法の開発を背景に-2008
- Author(s)
  清水弘樹
- Organizer
  HiNTセミナー2008-5
- Place of Presentation
  札幌
- Year and Date
  2008-08-26
- Data Source
  KAKENHI-PROJECT-19380064
[Presentation] Microwave Support for Glycosylations2007
- Author(s)
  Hiroki Shimizu, et. al.
- Organizer
  Gordon Conference
- Place of Presentation
  Tilton, U.S.A.
- Year and Date
  2007-06-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580109
[Presentation] Microwave Support for Glycosylations2007
- Author(s)
  Hiroki Shimizu, et. al.
- Organizer
  Gordon Conference, Carbohydrate
- Place of Presentation
  Tilton NH,U.S.A.
- Year and Date
  2007-06-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580109
[Presentation] Microwave can open a door to develop new glycosylations2007
- Author(s)
  Hiroki Shimizu, et. al.
- Organizer
  Benzon Symposium No.54
- Place of Presentation
  Denmark
- Year and Date
  2007-06-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580109
[Presentation] Microwave can open a door to develop new glycosylations2007
- Author(s)
  Hiroki Shimizu, et. al.
- Organizer
  Benzon Symposium No.54
- Place of Presentation
  Copenhagen,Denmark
- Year and Date
  2007-06-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580109
[Presentation] 糖認識15残基ペプチドp3の(NMRによる)構造解析2007
- Author(s)
  清水弘樹等
- Organizer
  第1回合同学術講演会
- Place of Presentation
  札幌
- Year and Date
  2007-07-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580109
[Presentation] Structural Study for p3 peptide bound for GM12007
- Author(s)
  Hiroki Shimizu, et. al.
- Organizer
  Semi-Annual Meeting of JSBBA Hokkaido 1st of 2007
- Place of Presentation
  Sapporo
- Year and Date
  2007-07-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580109
[Presentation] Microwave can open a door to develop new glycosylations2007
- Author(s)
  Hiroki Shimizu
- Organizer
  Benzon Symposium No.54
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2007-06-11
- Data Source
  KAKENHI-PROJECT-18580109
[Presentation] Microwave SupPort for Glycosylations2007
- Author(s)
  Hiroki Shimizu
- Organizer
  Gordon Conference, Carbohydrate
- Place of Presentation
  Tilton NH, U.S.A.
- Year and Date
  2007-06-19
- Data Source
  KAKENHI-PROJECT-18580109
[Presentation] A New Approach for Oligosaccharide Synthesis with Microwave Irradiation; Microwave is Helpful Even in a Low Temperature2006
- Author(s)
  Hiroki Shimizu, et. al.
- Organizer
  23rd International Carbohydrate Symposium
- Place of Presentation
  Whistler,Canada
- Year and Date
  2006-07-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580109
[Presentation] A New Approach for Oligosaccharide Synthesis with Microwave Irradiation ; Microwave is Helpful Even in a Low Temperature2006
- Author(s)
  Hiroki Shimizu, et. al.
- Organizer
  23rd International Carbohydrate Symposium
- Place of Presentation
  Whistler, Canada
- Year and Date
  2006-07-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580109
[Presentation] Carbohydrate Chemistry under Microwave Irradiation at Low Temperatures2006
- Author(s)
  Hiroki Shimizu, et. al.
- Organizer
  JSBBA Hokkaido-Tohoku Young Scientist meeting 2006
- Place of Presentation
  Touya
- Year and Date
  2006-11-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580109
[Presentation] Development of New Glycosylations Employing Microwave Irradiation for Solution Phase Synthesis and Gold Nanoparticles for Colloidal Phase Syntheses.2006
- Author(s)
  Hiroki Shimizu, et. al.
- Organizer
  26th Annual Meeting of Japanese Society for Carbohydrate Research
- Place of Presentation
  Sendai
- Year and Date
  2006-08-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580109
[Presentation] 低温下におけるマイクロ波照射を利用した糖鎖化学反応研究2006
- Author(s)
  清水弘樹等
- Organizer
  第6回マイクロ波効果・応用国際シンポジウム
- Place of Presentation
  大垣
- Year and Date
  2006-11-04
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580109
[Presentation] Study of Oligosaccharide Syntheses with Microwave Irradiation under Low Temperatures2006
- Author(s)
  Hiroki Shimizu, et. al.
- Organizer
  6th Symposium of Electromagnetic Wave Application
- Place of Presentation
  Ohgaki
- Year and Date
  2006-04-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580109
[Presentation] マイクロ波照射や金ナノ粒子を利用した、新規グリコシル化反応の開発研究2006
- Author(s)
  清水弘樹等
- Organizer
  第26回日本糖質学会年会
- Place of Presentation
  仙台
- Year and Date
  2006-08-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580109
[Presentation] マイクロ波を利用した新規グリコシル化反応2006
- Author(s)
  清水弘樹等
- Organizer
  平成18年度日本農芸化学会北海道・東北支部合同若手シンポジウム
- Place of Presentation
  洞爺
- Year and Date
  2006-11-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580109
[Presentation] 酵素反応へのマイクロ波利用研究
- Author(s)
  清水弘樹、長島生、作田智美
- Organizer
  第4回グライコバイオロジクス研究会
- Place of Presentation
  札幌市民ホール（札幌）
- Data Source
  KAKENHI-PROJECT-25293134

1. Matsuo Ichiro (40342852)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. SASAKI Masahide (60357126)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. HASHIMOTO Masaru (40212138)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. MIYAIRI Kazuo (10003526)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
5. SAITO Minoru (60196011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KIDOKORO Syunichi (80195320)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SHIMIZU Tetsuya (80435651)

# of Collaborated Projects: 1 results

# of Collaborated Products: 32 results
8. KAMEYAMA AKIHIKO (80415661)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. FUKUSHIMA Masami (40344113)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. AKASAKA Kazuaki (10201881)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. Yamaguchi Munehiro (60358231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Yamasaki Kazuhiko (00358243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 園山正史 (40242242)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 奥田徹哉 (20443179)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 鈴木哲朗 (00250184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 松岡浩司 (40272281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 杉山順一 (10235905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 加我晴生 (20356752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 大類洋 (20100050)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. 西村麻里江 (30370670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 舘野浩章 (30450670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. 久保田智巳 (90356923)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. NAKAGAWA Toshio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 城戸俊一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Shimizu Hiroki 清水 弘樹

SHIMIZU HIROKI 清水 弘樹

SHIMIZU Hiroki 清水 弘樹

清水 弘樹 シミズ ヒロキ

Research Projects

Research Products

Co-Researchers

Development of novel probes for a glycan for medicinal technology

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Development of auto-release system of non-toxic anti-fungal compounds triggered by enzymes produced by fungus itself.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Discovery and application of frequency dependence of microwave-assisted degradation of mucin

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Hydrolysis of lignocellulosic biomass with supercritical CO2

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Synthesis of a novel glyco-detergent for analysis of membrane protein

Principal Investigator

Project Period (FY)

Research Category

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Research of neutralizing antibody recognizing glycopeptides onto hepatitis C virus and basic studies for new diagnosesPrincipal Investigator

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Synthetic studies of unnatural beta1-4galactosyl cyclodextrinsPrincipal Investigator

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A reaction mechanism elucidation study based on many sugar-endo Type glycosidase complex analysi

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Study of Microwave Effects for Syntheses of Oligosaccharides and GlycopeptidesPrincipal Investigator

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Highly sensitive enantiomeric discrimination of chiral branched alkyl chains of fatty alcohols and amines, and the application to determine absolute stereochemistry of natural occurring products

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[Book] マイクロ波加熱の基礎と産業応用（第５章第２節「マイクロ波照射による糖鎖・糖ペプチド合成」）2017

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[Book] 糖鎖の新機能開発応用ハンドブック、第4編 第1章 4-4 マイクロ波合成2015

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[Book] 最新 マイクロ波エネルギーと応用技術、第5章 5-3 生体高分子合成 (糖鎖、ペプチド、糖ペプチド)2014

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[Journal Article] Structural Basis for Specific Recognition of Core Fucosylation in N-glycans by Pholiota Squarrosa Lectin (PhoSL)2019

Shimizu Hiroki 清水弘樹

SHIMIZU HIROKI 清水弘樹

SHIMIZU Hiroki 清水弘樹

清水弘樹シミズヒロキ

[Book] 糖鎖の新機能開発応用ハンドブック、第4編第1章 4-4 マイクロ波合成2015

[Book] 最新マイクロ波エネルギーと応用技術、第5章 5-3 生体高分子合成 (糖鎖、ペプチド、糖ペプチド)2014