Sawada Hirofumi 澤田博文

… Alternative Names

SAWADA Hirofumi 澤田博文

澤田博文サワダヒロフミ

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Researcher Number	30362354
Other IDs	https://orcid.org/0000-0001-8069-5751
Affiliation (Current)	2025: 三重大学, 医学部附属病院, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 三重大学, 医学部附属病院, 准教授 2016 – 2023: 三重大学, 医学系研究科, 講師 2022: 三重大学, 医学部附属病院, 講師 2017: 三重大学, 医学部附属病院, その他 2014 – 2015: 三重大学, 医学(系)研究科(研究院), 講師 … More 2014: 三重大学, 大学院医学系研究科, 講師 2011 – 2013: 三重大学, 医学(系)研究科(研究院), 助教 2005 – 2007: 三重大学, 医学部附属病院, 診療等従事者 Less
Review Section/Research Field	Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Anesthesiology / Pediatrics / Basic Section 58010:Medical management and medical sociology-related / Basic Section 56040:Obstetrics and gynecology-related / Basic Section 55060:Emergency medicine-related / Basic Section 53030:Respiratory medicine-related / Anesthesiology/Resuscitation studies
Keywords	Principal Investigator 肺高血圧 / ラット / 炎症 / ゲノム編集 / 肺動脈性肺高血圧 / 動物モデル / 閉塞性肺血管病変 / 骨形成因子受容体２型 / 遺伝子改変動物 / ラットモデル … More / 遺伝子変異 / 炎症機序 / サイトカイン / モノクロタリン … More Except Principal Investigator 肺高血圧 / 動物モデル / 炎症 / 肺動脈性肺高血圧 / モノクロタリン / 一酸化窒素 / MCP1 / 周産期刺激 / ゲノム編集 / 平滑筋 / 血管平滑筋 / 肺高血圧症 / Deep Learning / 神経損傷 / 静脈穿刺 / 気管支肺異形成症（BPD) / 子宮内胎児発育不全（FGR) / 肺高血圧症(PH) / エピゲネシス / hypoxia / Sugen / ATOH8 / 動物実験 / ノックアウトラット / ケモカイン / CCR2 / 新生内膜形成 / トランスクリプトーム解析 / 創薬 / トランスクリプトーム / バーカー仮説 / 周産期 / 肺動脈平滑筋 / DNAメチル化 / DOHaD仮説 / 周産期侵襲 / エピゲノム / 外科 / TRPV4 / イオンチャネル / ＴＲＰＶ / TRPV / 生理学 / 組織 / pulmonary hypertension / 血管生物学 / エンドセリン / 病態 / 治療 / uncoupled NOS / 低酸素 / Febuxostat / フェブキソスタット / キサンチンオキシダーゼ / スーパーオキシド / NaHS / 慢性低酸素 / 硫化水素ナトリウム / 硫化水素 / 細胞死 / 退縮 / 増悪 / ラットモデル / 小児循環器学 / 小児科学 / 転写因子 / 骨形成蛋白 / 遺伝子異常 / 骨形成蛋白受容体 / 酸化ストレス / 原因遺伝子 Less

周産期侵襲による実験的肺高血圧の薬物療法の開発と病態解明：DOHaD仮説の応用
- Principal Investigator
  
  三谷義英
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Mie University
Effects of intrauterine fetal growth retardation on pulmonary circulation and right heart function in adulthood
- Principal Investigator
  
  淀谷典子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Mie University
Deep Learningを活用した超音波ガイドによる安全な静脈穿刺法の開発
- Principal Investigator
  
  大橋啓之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58010:Medical management and medical sociology-related
- Research Institution
  Mie University
病変形成機序に基づく肺高血圧の新規治療標的の開発Principal Investigator
- Principal Investigator
  
  澤田博文
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Mie University
Elucidation of epigenome-mediated mechanisms involved in experimental pulmonary hypertension induced by perinatal insult
- Principal Investigator
  
  Mitani Yoshihide
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Mie University
肺高血圧発症における内皮選択的ずり応力反応転写因子ATOH8の役割
- Principal Investigator
  
  丸山一男
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Suzuka University of Medical Science
  Mie University
Mechanisms of neointima formation in pulmonary hypertension: an approach using pulmonary transcriptome analysis.
- Principal Investigator
  
  Yodoya Noriko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Mie University
Contribution of vascular smooth muscle cells and inflammation to the development of occlusive pulmonary vascular disease
- Principal Investigator
  
  Mitani Yoshihide
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Mie University
Role of BMPR2 mutation in Pulmonary Hypertension in RatsPrincipal Investigator
- Principal Investigator
  
  Sawada Hirofumi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Mie University
Analysis of TRPV channel in experimantal pulmonary hypertension and treatment
- Principal Investigator
  
  Maruyama Kazuo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Mie University
Treatment with NO-dependent activated nitrite in experimental pulmonary hypertension
- Principal Investigator
  
  Zhang Erquan
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Mie University
New treatment for pulmonary arterial hypertension targeting on inflammation-dedifferentiation pathway
- Principal Investigator
  
  Mitani Yoshihide
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Mie University
Role of inflammatory mechanism in the experimental model of pulmonary arterial hypertensionPrincipal Investigator
- Principal Investigator
  
  Sawada Hirofumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Mie University
Role of superoxide in pulmonary hypertension and treatment with xanthine oxidase inhibition
- Principal Investigator
  
  Yokochi Ayumu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Mie University
Molecular mechanisms involved in the pathogenesis of occlusive pulmonary vasculopathy
- Principal Investigator
  
  MITANI Yoshihide
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Mie University
pulmonary hypertension and hydrogen sulfate
- Principal Investigator
  
  MARUYAMA Kazuo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Mie University
Induction of pulmonary hypertension by inflammatory stimuli in mice with genetically reduced BMPR2Principal Investigator
- Principal Investigator
  
  SAWADA Hirofumi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Mie University
Molecular basis of pulmonary hypertension using mice deficient ina causative gene and an oxidant stress-related gene
- Principal Investigator
  
  YOSHIHIDE Mitani
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Mie University
肺高血圧血管病変に関わるNF-κB活性化を介した炎症性メディエーターの役割Principal Investigator
- Principal Investigator
  
  澤田博文
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Mie University

[Book] Molecular Mechanism of congenital heart disease and pulmonary hypertension2021
- Author(s)
  Yoshihide Mitani, Hirofumi Sawada
- Total Pages
  3
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-18K07841
[Book] Endogenous and Inhaled Nitric Oxide for the Treatment of Pulmonary Hypertension.2019
- Author(s)
  Maruyama K, Maruyama J, Sawada H.
- Publisher
  IntechOpen 2019 DOI: 10.5772/intechopen.89381
- Data Source
  KAKENHI-PROJECT-17K11075
[Book] PULMONARY　HYPERTENSION　　4. Nitric oxide in pathophysiology and treatment of pulmonary hypertension2013
- Author(s)
  Junko Maruyama, Yokochi A,　Zhang E, Sawada H,　Maruyama K.
- Total Pages
  233
- Publisher
  INTECH
- Data Source
  KAKENHI-PROJECT-24592333
[Book] 小児科診療ガイド2012
- Author(s)
  澤田　博文　三谷　義英
- Total Pages
  5
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-23591565
[Book] Nitric oxide in the pathophysiology and treatment of pulmonary hypertension(SBN 980-953-307-704-3)
- Author(s)
  Maruyama J, Zhang E, Yokochi A, Sawada H Maruyama K.
- Publisher
  InTech, Pulmonary Hypertension
- URL
  http://dx.doi.org/10.5772/55680
- Data Source
  KAKENHI-PROJECT-23591565
[Journal Article] Role of BMPR2 Mutation in the Development of RV Failure in Rat Experimental Pulmonary Hypertension K2023
- Author(s)
  azunobu Ohya, Hirofumi Sawada, Yoshihide Mitani, NAOKI TSUBOYA, Mami Takeoka, Noriko Yodoya, Hiroyuki Ohashi, Hiromasa Ito, Ryuji Okamoto, Kaoru Dohi, Tomoji Mashimo, Kazuo Maruyama and Masahiro Hirayama
- Journal Title
  
  Circulation
  
  Volume: 148 Issue: Suppl_1
- DOI
  10.1161/circ.148.suppl_1.17226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09043, KAKENHI-PROJECT-22K07843, KAKENHI-PROJECT-18K08192
[Journal Article] Abstract 17665: School Electrocardiography Screening Program Prompts the Detection of Otherwise Unrecognized Atrial Septal Defect in Children in Japan2023
- Author(s)
  Yodoya Noriko、Sawada Hirofumi、Mitani Yoshihide、Ohashi Hiroyuki、TSUBOYA NAOKI、Ohya Kazunobu、Takeoka Mami、Hirayama Masahiro
- Journal Title
  
  Circulation
  
  Volume: 148 Issue: Suppl_1
- DOI
  10.1161/circ.148.suppl_1.17665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07843
[Journal Article] Erythema and Induration of Bacillus Calmette-Guerin Scar Associated With Multisystem Inflammatory Syndrome in Children in Japan: A Case Report2022
- Author(s)
  Tsuboya Naoki、Makino Hirotoshi、Mitani Yoshihide、Ito Michiko、Ohya Kazunobu、Morimoto Mari、Hanaki Ryo、Yodoya Noriko、Ohashi Hiroyuki、Sawada Hirofumi、Sugiyama Kenji、Hirayama Masahiro
- Journal Title
  
  Frontiers in Pediatrics
  
  Volume: 10 Pages: 849473-849473
- DOI
  10.3389/fped.2022.849473
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08565
[Journal Article] Perinatal hypoxia aggravates occlusive pulmonary vasculopathy in SU5416/hypoxia-treated rats later in life2022
- Author(s)
  Oshita H, Sawada H, Mitani Y, Tsuboya N, Kabwe JC, Maruyama J, Yusuf A, Ito H, Okamoto R, Otsuki S, Yodoya N, Ohashi H, Oya K, Kobayashi Y, Kobayashi I, Dohi K, Nishimura Y, Saitoh S, Maruyama K, Hirayama M
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol. 2022 Aug 1;323(2):L178-L192.
  
  Volume: 323 Issue: 2 Pages: 178-192
- DOI
  10.1152/ajplung.00422.2021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09043, KAKENHI-PROJECT-22K07843, KAKENHI-PROJECT-22K08098, KAKENHI-PROJECT-19K08578, KAKENHI-PROJECT-20K08565, KAKENHI-PROJECT-21K07817
[Journal Article] Lung damage created by high tidal volume ventilation in rats with monocrotaline-induced pulmonary hypertension2022
- Author(s)
  Masako Kawai 1 2 , Erquan Zhang 1 3 , Jane Chanda Kabwe , Amphone Okada , Junko Maruyama , Hirofumi Sawada , Kazuo Maruyama
- Journal Title
  
  BMC Pulmonary Medicine
  
  Volume: 78 Issue: 1 Pages: 1-13
- DOI
  10.1186/s12890-022-01867-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16464, KAKENHI-PROJECT-18K08192, KAKENHI-PROJECT-21K09043, KAKENHI-PROJECT-22K07843, KAKENHI-PROJECT-20K08565
[Journal Article] CRISPR-mediated Bmpr2 point mutation exacerbates late pulmonary vasculopathy and reduces survival in rats with experimental pulmonary hypertension2022
- Author(s)
  Kabwe JC, Sawada H, Mitani Y, Oshita H, Tsuboya N, Zhang E, Maruyama J, Miyasaka Y, Ko H, Oya K, Ito H, Yodoya N, Otsuki S, Ohashi H, Okamoto R, Dohi K, Nishimura Y, Mashimo T, Hirayama M, Maruyama K.
- Journal Title
  
  Respir Res.
  
  Volume: ;23 Issue: 1 Pages: 1-22
- DOI
  10.1186/s12931-022-02005-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08192, KAKENHI-PROJECT-22K07843, KAKENHI-PROJECT-22K08098, KAKENHI-PROJECT-19K08578, KAKENHI-PROJECT-20K08565, KAKENHI-PROJECT-18KK0307, KAKENHI-PROJECT-21K07817
[Journal Article] Model difference in the effect of cilostazol on the development of experimental pulmonary hypertension in rats2021
- Author(s)
  Ito T、Zhang E、Omori A、Kabwe J、Kawai M、Maruyama J、Okada A、Yokochi A、Sawada H、Mitani Y、Maruyama K
- Journal Title
  
  BMC Pulmonary Medicine
  
  Volume: 21 Issue: 1 Pages: 377-377
- DOI
  10.1186/s12890-021-01710-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08192, KAKENHI-PROJECT-20K08565, KAKENHI-PROJECT-21K09043, KAKENHI-PROJECT-18K16464
[Journal Article] A non-selective endothelin receptor antagonist bosentan modulates kinetics of bone marrow-derived cells in ameliorating pulmonary hypertension in mice.2020
- Author(s)
  Kato T, Mitani Y, Masuya M, Maruyama J, Sawada H, Ohashi H, Ikeyama Y, Otsuki S, Yodoya N, Shinohara T, Miyata E, Zhang E, Katayama N, Shimpo H, Maruyama K, Komada Y, Hirayama M.
- Journal Title
  
  Pulm Circ.
  
  Volume: 10 Issue: 2 Pages: 1-9
- DOI
  10.1177/2045894020919355
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08192, KAKENHI-PROJECT-20K08155, KAKENHI-PROJECT-18K07841
[Journal Article] Prediction of Pulmonary to Systemic Flow Ratio in Patients With Congenital Heart Disease Using Deep Learning-Based Analysis of Chest Radiographs2020
- Author(s)
  Shuhei Toba, MD; Yoshihide Mitani, MD, PhD; Noriko Yodoya, MD; Hiroyuki Ohashi, MD; Hirofumi Sawada, MD, PhD; Hidetoshi Hayakawa,MD, PhD; Masahiro Hirayama, MD, PhD; Ayano Futsuki, MD; Naoki Yamamoto, MD; Hisato Ito,MD, PhD; Takeshi Konuma, MD, PhD; Hideto Shimpo,MD, PhD; Motoshi Takao, MD, PhD
- Journal Title
  
  JAMA Cardiology
  
  Volume: - Issue: 4 Pages: 449-457
- DOI
  10.1001/jamacardio.2019.5620
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17559, KAKENHI-PROJECT-18K07841
[Journal Article] A non-selective endothelin receptor antagonist bosentan modulates kinetics of bone marrow-derived cells in ameliorating pulmonary hypertension in mice.2020
- Author(s)
  Kato T, Mitani Y, Sawada H, Ohashi H, Otsuki S, Yodoya N, Shinohara T, Masuya M, Shimpo H, Maruyama K, Komada Y, Hirayama M.
- Journal Title
  
  Pulm Circ
  
  Volume: 1 Pages: 1-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07841
[Journal Article] Endogenous and Inhaled Nitric Oxide for the Treatment of Pulmonary Hypertension2019
- Author(s)
  Maruyama Kazuo、Maruyama Junko、Sawada Hirofumi
- Journal Title
  
  IntechOpen
  
  Volume: 1 Pages: 89381-89381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10140
[Journal Article] The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension2019
- Author(s)
  Morikawa M、Mitani Y、Holmborn K、Kato T、Koinuma D、Maruyama J、Vasilaki E、Sawada H、Kobayashi M、Ozawa T、Morishita i、Bessho Y、Maeda S、Ledin J、Aburatani H、Kageyama R、Maruyama K、Heldin C-H、Miyazono K
- Journal Title
  
  Science Signaling
  
  Volume: 12 Issue: 607 Pages: 607-607
- DOI
  10.1126/scisignal.aay4430
- NAID
  120006902530
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08192, KAKENHI-PROJECT-19K22433, KAKENHI-PLANNED-17H06326, KAKENHI-PUBLICLY-19H04782, KAKENHI-PROJECT-18H02451, KAKENHI-PROJECT-17K11075, KAKENHI-PROJECT-18K07841
[Journal Article] Emergence and Characterization of Acute Coronary Syndrome in Adults After Confirmed or Missed History of Kawasaki Disease in Japan: A Japanese Nationwide Survey2019
- Author(s)
  Mitani Yoshihide、Tsuda Etsuko、Kato Hitoshi、Higaki Takashi、Fujiwara Masako、Ogawa Shunichi、Satoh Fumiko、Nakamura Yoshikazu、Takahashi Kei、Ayusawa Mamoru、Kobayashi Tohru、Ichida Fukiko、et al.
- Journal Title
  
  Frontiers in Pediatrics
  
  Volume: 7 Pages: 275-275
- DOI
  10.3389/fped.2019.00275
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07785, KAKENHI-PROJECT-18K07841
[Journal Article] 肺高血圧の基礎研究：小児肺高血圧に関連の深い実験モデル： -肺動脈性肺高血圧・気管支肺異形成・先天性横隔膜ヘルニア -2019
- Author(s)
  澤田　博文
- Journal Title
  
  日本小児循環器学会雑誌
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10140
[Journal Article] Detection of Pediatric Pulmonary Arterial Hypertension by School Electrocardiography Mass Screening2019
- Author(s)
  Sawada H, Mitani Y, Nakayama T, Fukushima H, Kogaki S, Igarashi T, Ichida F, Ono Y, Nakanishi T, Doi S, Ishikawa S, Matsushima M, Yamada O, Saji T
- Journal Title
  
  Am J Respir Crit Care Med
  
  Volume: 199 Pages: 1397-1406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10140
[Journal Article] The ALK-1/SMAD/ATOH8 axis protects against hypoxia and development of pulmonary arterial hypertension2019
- Author(s)
  Morikawa M, Mitani Y, Holmborn K, Kato T, Koinuma D, Maruyama J, Vasilaki E, Sawada H, Kobayashi M, Ozawa T, Morishita T, Bessho Y, Maeda S, Ledin J, Aburatani H, Kageyama R, Maruyama K, Heldin C-H, and Miyazono K.
- Journal Title
  
  Science Signaling
  
  Volume: 12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10140
[Journal Article] 総説肺高血圧の基礎研究：小児肺高血圧に関連の深い実験モデル： -肺動脈性肺高血圧・気管支肺異形成・先天性横隔膜ヘルニア2019
- Author(s)
  澤田博文
- Journal Title
  
  小児循環器学会雑誌
  
  Volume: 35 Pages: 99-111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10140
[Journal Article] Emergence and Characterization of Acute Coronary Syndrome in Adults After Confirmed or Missed History of Kawasaki Disease in Japan: A Japanese Nationwide Survey.2019
- Author(s)
  Mitani Y, Tsuda E, Kato H, Higaki T, Fujiwara M, Ogawa S, Satoh F, Nakamura Y, Takahashi K, Ayusawa M,Kobayashi T, Ichida F, Matsushima M, Kamada M, Suda K,Ohashi H, Sawada H, Komatsu T, Waki K, Shinoda M, Tsunoda R, Yokoi H, Hamaoka K.
- Journal Title
  
  Front Pediatr.
  
  Volume: 7 Pages: 275-275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10140
[Journal Article] Guidelines for Heart Disease Screening in Schools (JCS 2016/JSPCCS 2016)　― Digest Version ―2018
- Author(s)
  umitomo N, Baba R, Doi S, Higaki T, Horie M, Nagashima M, Niwa K, Ogawa S, Okumura K, Tsutsui H (et al. )
- Journal Title
  
  Circ J
  
  Volume: 82 Issue: 9 Pages: 2385-2444
- DOI
  10.1253/circj.CJ-66-0153
- NAID
  130007438850
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2018-08-24
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09495, KAKENHI-PROJECT-17K10140, KAKENHI-PROJECT-18K07813, KAKENHI-PROJECT-16H03255, KAKENHI-PROJECT-16K08866, KAKENHI-PROJECT-16K19627, KAKENHI-PROJECT-18K07841
[Journal Article] Detection of Pediatric Pulmonary Arterial Hypertension by School Electrocardiography Mass Screening2018
- Author(s)
  Sawada Hirofumi、Mitani Yoshihide、Nakayama Tomotaka、Fukushima Hiroyuki、Kogaki Shigetoyo、Igarashi Takehiro、Ichida Fukiko、Ono Yasuo、Nakanishi Toshio、Doi Shozaburo、Ishikawa Shiro、Matsushima Masaki、Yamada Osamu、Saji Tsutomu
- Journal Title
  
  American Journal of Respiratory and Critical Care Medicine
  
  Volume: 印刷中 Issue: 11 Pages: 1397-1406
- DOI
  10.1164/rccm.201802-0375oc
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10140, KAKENHI-PROJECT-18K07785, KAKENHI-PROJECT-18K07841
[Journal Article] Loss of PPAR in endothelial cells leads to impaired angiogenesis.2016
- Author(s)
  Vattulainen-Collanus S, Akinrinade O, Li M, Koskenvuo M, Li CG, Rao SP, de Jesus Perez V, Yuan K, Sawada H, Koskenvuo JW, Alvira C, Rabinovitch M, Alastalo TP.
- Journal Title
  
  J Cell Sci.
  
  Volume: 129 Pages: 693-705
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461606
[Journal Article] Loss of PPARγ in endothelial cells leads to impaired angiogenesis.2016
- Author(s)
  Vattulainen-Collanus S, Akinrinade O, Li M, Koskenvuo M, Li CG, Rao SP, de Jesus Perez V, Yuan K, Sawada H, Koskenvuo JW, Alvira C, Rabinovitch M, Alastalo TP.
- Journal Title
  
  J Cell Sci.
  
  Volume: 129 Pages: 693-705
- DOI
  10.1242/jcs.169011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461606
[Journal Article] Comparative Transcriptome Analysis Identifies CCDC80 as a Novel Gene Associated with Pulmonary Arterial Hypertension.2016
- Author(s)
  Yuhei Nishimura, Shota Sasagawa, Hirofumi Sawada, Erquan Zhang, Soichiro Murakami, Yoshifumi Ashikawa, Mizuki Yuge, Shiko Okabe, Koki Kawaguchi, Reiko Kawase, Yoshihide Mitani, Kazuo Maruyama, TOSHIO TANAKA.
- Journal Title
  
  Front. Pharmacol.,
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461606
[Journal Article] Potential Contribution of Phenotypically Modulated Smooth Muscle Cells and Related Inflammation in the Development of Experimental Obstructive Pulmonary Vasculopathy in Rats.2015
- Author(s)
  Otsuki S, Sawada H, Yodoya N, Shinohara T, Kato T, Ohashi H, Zhang E, Imanaka-Yoshida K, Shimpo H, Maruyama K, Komada Y, Mitani Y.
- Journal Title
  
  PLoS One.
  
  Volume: 10 Issue: 2 Pages: 0118655-0118655
- DOI
  10.1371/journal.pone.0118655
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591573, KAKENHI-PROJECT-24591574, KAKENHI-PROJECT-24592333, KAKENHI-PROJECT-24791057, KAKENHI-PROJECT-26461606, KAKENHI-PROJECT-15K09688
[Journal Article] Macitentan reverses early obstructive pulmonary vasculopathy in rats: early intervention in overcoming the survivin-mediated resistance to apoptosis.2015
- Author(s)
  Shinohara T, Sawada H, Otsuki S, Yodoya N, Kato T, Ohashi H, Zhang E, Saitoh S, Shimpo H, Maruyama K, Komada Y, Mitani Y.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol.
  
  Volume: 308(6) Issue: 6 Pages: L523-L538
- DOI
  10.1152/ajplung.00129.2014
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591574, KAKENHI-PROJECT-24592333, KAKENHI-PROJECT-24791057, KAKENHI-PROJECT-26461606, KAKENHI-PROJECT-15K09688
[Journal Article] Sarpogrelate hydrochloride, a serotonin 5HT2A receptor antagonist, ameliorates the development of chronic hypoxic pulmonary hypertension in rats2015
- Author(s)
  Zhang E, Maruyama J, et al.
- Journal Title
  
  J Anesth
  
  Volume: 29 Issue: 5 Pages: 715-723
- DOI
  10.1007/s00540-015-2015-y
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592333, KAKENHI-PROJECT-15K09199, KAKENHI-PROJECT-15K09688, KAKENHI-PROJECT-26461606
[Journal Article] Effect of thrombomodulin on the development of monocrotaline-induced pulmonary hypertension.2014
- Author(s)
  Yamada Y, Maruyama J, Zhang E, Maruyama K. et al
- Journal Title
  
  J Anesth
  
  Volume: 28(1) Issue: 1 Pages: 26-33
- DOI
  10.1007/s00540-013-1663-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591166, KAKENHI-PROJECT-24591574, KAKENHI-PROJECT-24592333, KAKENHI-PROJECT-24791056
[Journal Article] Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension.2014
- Author(s)
  Sawada H, Saito T, Nickel NP, Alastalo TP, Glotzbach JP, Chan R, Haghighat L, Fuchs G, Januszyk M, Cao A, Lai YJ, Perez Vde J, Kim YM, Wang L, Chen PI, Spiekerkoetter E, Mitani Y, Gurtner GC, Sarnow P, Rabinovitch M.
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 211 Issue: 2 Pages: 263-280
- DOI
  10.1084/jem.20111741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591565, KAKENHI-PROJECT-24591574
[Journal Article] Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension2014
- Author(s)
  Sawada H, Saito T, Nickel NP, Alastalo TP, Glotzbach JP, Chan R, Haghighat L, Fuchs G, Januszyk M, Cao A, Lai YJ, Perez Vde J, Kim YM, Wang L, Chen PI, Spiekerkoetter E, Mitani Y, Gurtner GC, Sarnow P, Rabinovitch M.
- Journal Title
  
  J Exp Med
  
  Volume: 211(2) Pages: 263-280
- Data Source
  KAKENHI-PROJECT-23591565
[Journal Article] Effect of thrombomodulin on the development of monocrotaline-induced pulmonary hypertension2014
- Author(s)
  Yamada Y, Maruyama J, Zhang E, Okada A, Yokochi A, Sawada H, Mitani Y, Hayashi T, Suzuki K, Maruyama K.
- Journal Title
  
  J Anesth
  
  Volume: 28(1) Pages: 26-33
- Data Source
  KAKENHI-PROJECT-23591565
[Journal Article] Thrombomodulin protects against lung damage created by high level of oxygen with large tidal volume mechanical ventilation in rats.2014
- Author(s)
  Iwashita Y, Zhang E, Maruyama J, Yokochi A, Yamada Y, Sawada H, Mitani Y, Imai H, Suzuki K, Maruyama K.
- Journal Title
  
  J Intensice Care
  
  Volume: 2 Issue: 1 Pages: 57-57
- DOI
  10.1186/s40560-014-0057-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592333
[Journal Article] Chronic effects of pulmonary artery stenosis on hemodynamic and structural development of the lungs2013
- Author(s)
  Razavi H, Stewart SE, Xu C, Sawada H, Zarafshar SY, Taylor CA, Rabinovitch M, Feinstein JA.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol
  
  Volume: 304(1)
- Data Source
  KAKENHI-PROJECT-23591565
[Journal Article] Public access defibrillation improved the outcome after out-of-hospital cardiac arrest in school-age children : a nationwide, population-based, Utstein registry study in Japan2013
- Author(s)
  Mitani Y, Ohta K, Yodoya N, Otsuki S, Ohashi H, Sawada H, Nagashima M, Sumitomo N, Komada Y.
- Journal Title
  
  Europace
  
  Volume: 15(9) Pages: 1259-1266
- Data Source
  KAKENHI-PROJECT-23591565
[Journal Article] FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension2013
- Author(s)
  Spiekerkoetter E, Tian X, Cai J, Hopper RK, Sudheendra D, Li CG, El-Bizri N, Sawada H, Rabinovitch M.
- Journal Title
  
  J Clin Invest
  
  Volume: 123(8) Pages: 3600-3613
- Data Source
  KAKENHI-PROJECT-23591565
[Journal Article] Public access defibrillation improved the outcome after out-of-hospital cardiac arrest in school-age children: a nationwide, population-based, Utstein registry study in Japan2013
- Author(s)
  Mitani Y, Ohta K, Yodoya N, Otsuki S, Ohashi H, Sawada H, Nagashima M, Sumitomo N, Komada Y.
- Journal Title
  
  Europace
  
  Volume: 15 Issue: 9 Pages: 1259-66
- DOI
  10.1093/europace/eut053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591572, KAKENHI-PROJECT-24591574, KAKENHI-PROJECT-24791056
[Journal Article] Chronic effects of pulmonary artery stenosis on hemodynamic and structural development of the lungs.2013
- Author(s)
  Razavi H, Stewart SE, Xu C, Sawada H, Zarafshar SY, Taylor CA, Rabinovitch M, Feinstein JA.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol.
  
  Volume: 304 Issue: 1 Pages: L17-L28
- DOI
  10.1152/ajplung.00412.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591565
[Journal Article] Loss of adenomatous poliposis coli-α3 integrin interaction promotes endothelial apoptosis in mice and humans.2012
- Author(s)
  de Jesus Perez VA, Yuan K, Orcholski ME, Sawada H, Zhao M, Li CG, Tojais NF, Nickel N, Rajagopalan V, Spiekerkoetter E, Wang L, Dutta R, Bernstein D, Rabinovitch M.
- Journal Title
  
  Circ Res.
  
  Volume: 111 Issue: 12 Pages: 1551-64
- DOI
  10.1161/circresaha.112.267849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591565
[Journal Article] Loss of adenomatous poliposis coli-α3 integrin interaction promotes endothelial apoptosis in mice and humans2012
- Author(s)
  de Jesus Perez VA, Yuan K, Orcholski ME, Sawada H, Zhao M, Nickel N, Rajagopalan V, Spiekerkoetter E, Wang L, Dutta R, Bernstein D, Rabinovitch M.
- Journal Title
  
  Circ Res
  
  Volume: 111(12) Pages: 1551-1564
- Data Source
  KAKENHI-PROJECT-23591565
[Journal Article] Neutrophil elastase is produced by pulmonary artery smooth muscle cells and is linked to neointimal lesions2011
- Author(s)
  Kim YM, Haghighat L, Spiekerkoetter E, Sawada H, Alvira CM, Wang L, Acharya S, Rodriguez-Colon G, Orton A, Zhao M, Rabinovitch M.
- Journal Title
  
  Am J Pathol
  
  Volume: 179(3) Pages: 1560-1572
- Data Source
  KAKENHI-PROJECT-23591565
[Journal Article] Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival2011
- Author(s)
  Alastalo TP, Li M, Perez Vde J, Pham D, Sawada H, Wang JK, Koskenvuo M, Wang L, Rabinovitch M.
- Journal Title
  
  J Clin Invest
  
  Volume: 121(9) Pages: 3735-3746
- Data Source
  KAKENHI-PROJECT-23591565
[Journal Article] Neutrophil elastase is produced by pulmonary artery smooth muscle cells and is linked to neointimal lesions.2011
- Author(s)
  Kim YM, Haghighat L, Spiekerkoetter E, Sawada H, Alvira CM, Wang L, Acharya S, Rodriguez-Colon G, Orton A, Zhao M, Rabinovitch M
- Journal Title
  
  Am J Pathol
  
  Volume: 179 Pages: 1560-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591565
[Journal Article] BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways2011
- Author(s)
  Perez VA, Ali Z, Alastalo TP, Ikeno F, Sawada H, Lai YJ, Kleisli T, Spiekerkoetter E, Qu X, Rubinos LH, Ashley E, Amieva M, Dedhar S, Rabinovitch M.
- Journal Title
  
  J Cell Biol
  
  Volume: 192(1) Pages: 171-188
- Data Source
  KAKENHI-PROJECT-23591565
[Journal Article] Quantitative characterization of postnatal growth trends in proximal pulmonary arteries in rats by phase-contrast magnetic resonance imaging2011
- Author(s)
  Razavi H, Zarafshar SY, Sawada H, Taylor CA, Feinstein JA.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol
  
  Volume: 301(3)
- Data Source
  KAKENHI-PROJECT-23591565
[Journal Article] Quantitative characterization of postnatal growth trends in proximal pulmonary arteries in rats by phase-contrast magnetic resonance imaging.2011
- Author(s)
  Razavi H, Zarafshar SY, Sawada H, Taylor CA, Feinstein JA
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol.
  
  Volume: 301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591565
[Journal Article] Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival.2011
- Author(s)
  Alastalo TP, Li M, Perez Vde J, Pham D, Sawada H, Wang JK, Koskenvuo M, Wang L, Freeman BA, Chang HY, Rabinovitch M.
- Journal Title
  
  J Clin Invest
  
  Volume: 121 Issue: 9 Pages: 3735-46
- DOI
  10.1172/jci43382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591565
[Journal Article] BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways2011
- Author(s)
  Perez VA, Ali Z, Alastalo TP, Ikeno F, Sawada H, Lai YJ, Kleisli T, Spiekerkoetter E, Qu X, Rubinos LH, Ashley E, Amieva M, Dedhar S, Rabinovitch M
- Journal Title
  
  J Cell Biol.
  
  Volume: 192 Pages: 171-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591565
[Journal Article] Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension2011
- Author(s)
  Lee SJ, Smith A, Guo L, Alastalo TP, Li M, Sawada H, Liu X, Chen ZH, Ifedigbo E, Jin Y, Feghali-Bostwick C , Kim HP, Rabinovitch M, Choi AM.
- Journal Title
  
  Am J Respir Crit Care Med
  
  Volume: 183(5) Pages: 649-658
- Data Source
  KAKENHI-PROJECT-23591565
[Journal Article] Fatal pulmonary lymphangiectasia manifesting after repeated surgeries for intractable chylopericardium and chylothorax in a 20-month-old girl.2008
- Author(s)
  Kamada N, Mitani Y, Kihira K, Iwao A, Sinoki T, Ikeyama Y, Sawada H, Deguchi T, Takabayashi S, Shimpo H, Komada Y.
- Journal Title
  
  Circulation 117
  
  Pages: 1894-1896
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591202
[Journal Article] Atrial natriuretic peptide gene transfection with a novel envelope vector system ameliorates pulmonary hypertension in rats.2008
- Author(s)
  Mitani Y, Maruyama J, Jiang BH, Sawada H, Shimpo H, Imanaka-Yoshida K, Kaneda Y, Komada Y, Maruyama K.
- Journal Title
  
  J Thorac Cardiovasc Surg 136
  
  Pages: 142-149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591202
[Journal Article] A nuclear factor-κB inhibitor pyrrolidine dithiocarbamate ameriolates pulmonary hypertension in rats2007
- Author(s)
  Sawada H(1), Mitani Y(2), Shimpo H(8), Maruyama K(10)
- Journal Title
  
  Chest 132(4)
  
  Pages: 1265-1274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591202
[Journal Article] A nuclear factor-κB inhibitor pyrrolidine dithiocarbamate ameriolates pulmonary hypertension in rats.2007
- Author(s)
  Sawada H, Mitani Y, et. al.
- Journal Title
  
  Chest 133
  
  Pages: 1265-1274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591202
[Journal Article] Role of High Mobility Box 1 in Monocorotaline-induced Pulmonary Hypertension in Rats2007
- Author(s)
  Hirofumi Sawada et al.
- Journal Title
  
  Circulation Journal Vol 71 Suppl 1
  
  Pages: 231-232
- Data Source
  KAKENHI-PROJECT-17790701
[Journal Article] Reversal of increased pulmonary arterialpressure associated with systemic venouscollaterals after tonsillectomy in aFontan candidate after Glenn procedure:Impact of obstructive sleep apnea onFontan circulation2007
- Author(s)
  Sawada H(1), Mitani Y(2), Shimpo H(7), Maruyama K(8)
- Journal Title
  
  J Thorac Cardiovasc Surg 133(5)
  
  Pages: 1371-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591202
[Journal Article] Reversal of increased pulmonary arterial pressure associated with systemic venous collaterals after tonsillectomy in a Fontan candidate after Glenn procedure:Impact of obstructive sleep apnea on Fontan circulation.2007
- Author(s)
  Sawada H, Mitani Y, et. al.
- Journal Title
  
  J Thorac Cardiovasc Surg 133
  
  Pages: 1371-1373
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591202
[Journal Article] Emergent permanent pacemaker implantation in a premature 1,502 g neonate.2005
- Author(s)
  Takabayashi S, Ito H, Shimpo H, Sawada H, et al.
- Journal Title
  
  Jpn J Thorac Cardiovasc Surg. 53(4)
  
  Pages: 199-201
- NAID
  10015658276
- Data Source
  KAKENHI-PROJECT-17790701
[Journal Article] Fate of the ‘opened' arterial duct : Lessons learned from bilateral pulmonary artery banding for hypoplastic left heart syndrome under the continuous infusion of prostaglandin E 1.(abstract)2005
- Author(s)
  Mitani Y, Sawada H, Takabayashi S, et al.
- Journal Title
  
  Circulation 112(17)
- Data Source
  KAKENHI-PROJECT-17790701
[Journal Article] Anesthetic management of a neonate with vein or Galen aneurysmal malformations and severe pulmonary hypertension.2005
- Author(s)
  Ashida Y, Miyahara H, Sawada H et al.
- Journal Title
  
  Paediatr Anaesth 15(6)
  
  Pages: 525-528
- Data Source
  KAKENHI-PROJECT-17790701
[Journal Article] Incorporation of bone marrow-derived cells into pulmonary vascular lesions in mice exposed to chronic hypoxia : endothelial cells and fibroblasts.(abstract)2005
- Author(s)
  Sawada H, Mitani Y, Maruyama J et al.
- Journal Title
  
  Circulation 112(17)
- Data Source
  KAKENHI-PROJECT-17790701
[Presentation] Therapeutic insights into pulmonary vasculopathy and RV failure in BMPR2 mutation carriers: learnings from Bmpr2 mutant rat model2024
- Author(s)
  Hirofumi Sawada
- Organizer
  The 88th Annual Scientific Meeting of the Japanese Circulation Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07843
[Presentation] Mild pulmonary hypertension (mPAP:21-24mmHg) is highly prevalent in children with developmental lung disorders and associated with impaired lung vascular growth2024
- Author(s)
  Hirofumi Sawada
- Organizer
  The 88th Annual Scientific Meeting of the Japanese Circulation Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07843
[Presentation] 肺高血圧の動物モデル2024
- Author(s)
  澤田博文
- Organizer
  日本小児循環器学会第15回教育セミナーAdvanced Course
- Invited
- Data Source
  KAKENHI-PROJECT-22K07843
[Presentation] ゲノム編集ラットモデルを用いた肺高血圧研究2024
- Author(s)
  澤田博文
- Organizer
  第17回　ラットリソースリサーチ研究会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07843
[Presentation] Role of BMPR2 Mutation in the Development of RV Failure in Rat Experimental Pulmonary Hypertension2023
- Author(s)
  Kazunobu Ohya, Hirofumi Sawada, Yoshihide Mitani, NAOKI TSUBOYA, Mami Takeoka, Noriko Yodoya, Hiroyuki Ohashi, Hiromasa Ito, Ryuji Okamoto, Kaoru Dohi, Tomoji Mashimo, Kazuo Maruyama and Masahiro Hirayama
- Organizer
  American Heart Association 2023 Abstract 17226
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09043
[Presentation] 新生児慢性肺疾患に伴う肺高血圧の肺血行動態評価　 -成人期を見据えた長期管理に向けて-2023
- Author(s)
  澤田博文
- Organizer
  第67回日本新生児成育医学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07843
[Presentation] 周産期肺障害に伴う慢性肺高血圧　-肺血行動態と血管造影でみるDevelopmental Lung Disorders-2023
- Author(s)
  澤田博文
- Organizer
  第59回日本周産期・新生児医学会　学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07843
[Presentation] 育セッション　「一般病院で診る肺高血圧」　小児期PAH - 初期診断のポイント -2023
- Author(s)
  澤田博文
- Organizer
  第87回日本循環器学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07843
[Presentation] Effects of Genetic Modifications of Bmpr2 and a Chemokine Receptor on Progressive Pulmonary Hypertension in Rats: What Does CRISPR/Cas9 Bring to Pulmonary Hypertension Research?2022
- Author(s)
  Hirofumi Sawada
- Organizer
  第86回日本循環器学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08565
[Presentation] 教育セッション「一般病院で診る肺高血圧」小児期PAH - 初期診断のポイント -2022
- Author(s)
  澤田博文
- Organizer
  第87回日本循環器学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08565
[Presentation] Perinatal hypoxia aggravates occlusive pulmonary vasculopathy in rats later in life: association with epigenetic changes.2022
- Author(s)
  Hironori Oshita, Yoshihide Mitani, Hirofumi Sawada, Naoki Tsuboya, Junko Maruyama, Noriko Yodoya, Hiroyuki Ohashi, Kazunobu Oya, Yuhei Nishimura, Shinji Saitoh, Kazuo Maruyama, Masahiro Hirayama
- Organizer
  Association for European Pediatric and Congenital Cardiology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07817
[Presentation] Effects of Genetic Modifications of Bmpr2 and a Chemokine Receptor on Progressive Pulmonary Hypertension in Rats: What Does CRISPR/Cas9 Bring to Pulmonary Hypertension Research?2022
- Author(s)
  Hirofumi Sawada
- Organizer
  第86回日本循環器学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07843
[Presentation] Automated analysis of 12-lead electrocardiogram for pediatric cardiac disease mass screening in school-age children by the combined use of signal processing and deep learning2020
- Author(s)
  Shuhei Toba; Yoshihide Mitani; Yusuke Sugitani, Hiroyuki Ohashi; Hirofumi Sawada; Masahiro Hirayama
- Organizer
  American Heart Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07841
[Presentation] BMPR2変異はラット肺高血圧モデルにおいて進行期の病態と生命予後を悪化させる CRISPR/Cas9ゲノム編集ラットを用いた検討2020
- Author(s)
  澤田博文、Jane C Kabwe、三谷義英、淀谷典子、大橋啓之、大矢和伸、坪谷尚季、早川豪俊、丸山一男、平山雅浩
- Organizer
  日本小児循環器学会
- Data Source
  KAKENHI-PROJECT-18K07841
[Presentation] 周産期低酸素は若年SUGEN/低酸素ラットにおいて肺動脈性肺高血圧を増悪させる：新たな致死性、進行性のPAHラットモデルとその分子的機序2020
- Author(s)
  大下裕法、三谷義英、澤田博文、坪谷尚季、Jane C. Kabwe、淀谷典子、大橋啓之、大矢和伸、丸山一男、平山雅浩
- Organizer
  日本小児循環器学会
- Data Source
  KAKENHI-PROJECT-18K07841
[Presentation] ヒト内在性レトロウイルスKは肺動脈内皮細胞において炎症と内皮間葉転換を誘導する2020
- Author(s)
  大槻祥一郎; Shalina Taylor; Jan-Renier Moonen; David Marciano; Aiqin Cao; Lingli Wang; Michal Bental Roof; 澤田博文; 三谷義英; Marlene Rabinovitch
- Organizer
  日本小児循環器学会
- Data Source
  KAKENHI-PROJECT-18K07841
[Presentation] 周産期侵襲は肺動脈性肺高血圧の発症、増悪の危険因子となるか:実験的検証2019
- Author(s)
  大下裕法、三谷義英、澤田博文、大橋啓之、淀谷典子、大矢伸伸、坪谷尚季、平山雅浩
- Organizer
  日本小児循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07841
[Presentation] Perinatal origin of pulmonary arterial hypertension: From a newly established fatal Sugen/Hypoxia rat model2019
- Author(s)
  Hironori Oshita, Hirofumi Sawada, Yoshihide Mitani, Jane C. Kabwe, Noriko Yodoya,Hiroyuki Ohashi, Kazuo Maruyama, Masahiro Hirayama.
- Organizer
  日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07841
[Presentation] Perinatal hypoxia aggravates occlusive pulmonary vasculopathy in the adolescent rats: Establishment of a fatal Sugen/Hypoxia model and its molecular basis2019
- Author(s)
  Hironori Oshita, Hirofumi Sawada, Yoshihide Mitani, Jane Kabwe, Noriko Yodoya, Naoki Tsuboya, Kazunobu Ohya, Hiroyuki Ohashi, Kazuo Maruyama, Masahiro Hirayama
- Organizer
  American Heart Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07841
[Presentation] erinatal Hypoxia Aggravates Occlusive Pulmonary Vasculopathy in the Adolescent Rats: Establishment of a Fatal Sugen/hypoxia Model and Its Molecular Basis2019
- Author(s)
  Hironori Oshita,Hirofumi Sawada,Yoshihide Mitani,Jane Kabwe,Noriko Yodoya,Naoki Tsuboya,Kazunobu Ohya,Hiroyuki Ohashi,Kazuo Maruyama,Masahiro Hirayama.
- Organizer
  American Heart Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10140
[Presentation] Inhaled Iloprost Added-On to Nitric Oxide Rescues a Neonate with Severe Congenital Diaphragmatic Hernia without Using Extracorporeal Membrane Oxygenation2019
- Author(s)
  Souya Kitamura, Hirofumi Sawada, Yoshihide Mitani, Hiroyuki Ohashi, Noriko Yodoya, Kazunobu Ooya, Kohei Matsushita, Yuki Koike, Kohei Otake, Mikihiro Inoue, Keiichi Uchida, Kazuo Maruyama and Masahiro Hirayama
- Organizer
  American Thoracic Society International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07841
[Presentation] 周産期・新生児期の病態に起因する肺高血圧へのアプローチ -多領域連携の重要性・必要性-2019
- Author(s)
  澤田博文、三谷義英、淀谷典子、大橋啓之、大矢和伸、坪谷尚季、北村創矢、早川豪俊、丸山一男、平山雅浩
- Organizer
  第55回日本小児循環器学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K10140
[Presentation] Quantitative Analysis of Chest X-Ray Using Deep Learning to Predict Pulmonary to Systemic Flow Ratio in Patients With Congenital Heart Disease2019
- Author(s)
  Shuhei Toba,Yoshihide Mitani,Hiroyuki Ohashi,Hirofumi Sawada,Noriko Yodoya,Hidetoshi Hayakawa,Masahiro Hirayama,Ayano Futsuki,Naok iYamamoto,Hisato Ito,Takeshi Konuma,Hideto Shimpo,Motoshi Takao
- Organizer
  American Heart Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10140
[Presentation] Role of BMPR2 Mutation in Monocrotaline-induced Pulmonary Hypertension: Analysis Using Rats with a Crispr/Cas9-induced Truncating BMPR2 mutation.2019
- Author(s)
  Kabwe JC, Sawada H, Mitani Y, Oshita H, Zhang E, Maruyama J, Hirayama M, Maruyama K
- Organizer
  Japanese Circulation Society. 2019. 3. 31. Yokohama Japan
- Data Source
  KAKENHI-PROJECT-17K11075
[Presentation] Quantitative Analysis of Chest X-ray Using Deep Learning to Predict Pulmonary to Systemic Flow Ratio in Patients with Congenital Heart Disease2019
- Author(s)
  Shuhei Toba, Yoshihide Mitani, Hiroyuki Ohashi, Hirofumi Sawada, Noriko Yodoya, Hidetoshi Hayakawa, Masahiro Hirayama, Ayano Futsuki, Naoki Yamamoto, Hisato Ito, Takeshi Konuma, Hideto Shimpo, Motoshi Takao
- Organizer
  American Heart Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07841
[Presentation] Role of BMPR2 Mutation in Monocrotaline-induced Pulmonary Hypertension: Analysis Using Rats with a Crispr/Cas9-induced Truncating BMPR2 mutation.2019
- Author(s)
  Kabwe JC, Sawada H, Mitani Y, Oshita H, Zhang E, Maruyama J, Hirayama M, Maruyama K
- Organizer
  Japanese Circulation Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10140
[Presentation] 閉塞性肺血管病変の退縮に向けた実験的アプローチ2019
- Author(s)
  澤田博文
- Organizer
  1st Japan PAH Frontier Summit
- Invited
- Data Source
  KAKENHI-PROJECT-17K10140
[Presentation] Inhaled Iloprost Added-On to Nitric Oxide Rescues a Neonate with Severe Congenital Diaphragmatic Hernia without Using Extracorporeal Membrane Oxygenation2019
- Author(s)
  Kitamura S, Sawada H, Mitani Y, Ohashi H, Yodoya N, Ooya K, Matsushita K, Koike Y, Otake K, Inoue M, Uchida K, Maruyama K and Hirayama M
- Organizer
  American Thoracic Society International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10140
[Presentation] 周産期ストレスによるラット肺動脈性肺高血圧の増悪効果2019
- Author(s)
  大下裕法、三谷義英、澤田博文、大橋啓之、淀谷典子、大矢和伸、坪谷尚季、平山雅浩
- Organizer
  日本肺高血圧肺循環学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07841
[Presentation] Role of BMPR2 Mutation in Monocrotaline-induced Pulmonary Hypertension: Analysis Using Rats with a Crispr/Cas9-induced Truncating BMPR2 mutation2019
- Author(s)
  Jane Kabwe, Hirofumi Sawada, Yoshihide Mitani, Hironori Oshita, Erquan Zhang, Junko Maruyama, Masahiro Hirayama, Kazuo Maruyama
- Organizer
  Japanese Circulation Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10140
[Presentation] 新規PAH治療標的開発に向けた肺トランスクリプトーム解析の利用2018
- Author(s)
  澤田博文、三谷義英、大下裕法、篠原務、Jane C. Kabwe、淀谷典子、大橋啓之、西村有平、丸山一男、平山雅浩
- Organizer
  日本小児循環器学会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K10140
[Presentation] Lung Biopsy Findings in Children with Severe Pulmonary Hypertension Which is Associated with but Unexplained by Coexisting Congenital Systemic to Pulmonary Shunt: Implications into the Role of Acute Vasodilator Testing in Operability2017
- Author(s)
  Hirofumi Sawada, Hiroyuki Ohashi, Shoichiro Ohtsuki, Noriko Yodoya, Hidetoshi Hayakawa , Takeshi Konuma, Hideto Shimpo, Kyoko Imanaka-Yoshida Kazuo Maruyama ,　Masahiro Hirayama and Yoshihide Mitani .
- Organizer
  American Thoracic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09688
[Presentation] Differentially Expressed Genes in Early and Late Treatment for Occlusive Pulmonary Vasculopathy in Sugen/hypoxia Models: Molecular Basis for Early Treatment2017
- Author(s)
  Yoshihide Mitani, Hirofumi Sawada, Tsutomu Shinohara, Shoichiro Otsuki, Noriko Yodoya, Hiroyuki Ohashi, Taichi Kato, Erquan Zhang, Yuhei Nishimura, Toshio Tanaka, Kazuo Maruyama, Masahiro Hirayama.
- Organizer
  American Heart Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09688
[Presentation] Macitentan Reverses Early Obstructive Pulmonary Vasculopathy in Rats: Early Intervention in Overcoming the Survivin-mediated Resistance to Apoptosis2015
- Author(s)
  Shinohara T., Sawada H., Otsuki S., Yodoya N., Kato T., Ohashi H., Zhang E., Saitoh S., Shimpo H., Maruyama K., Komada Y., Mitani Y.
- Organizer
  Association for European Pediatric and Congenital Cardiology
- Place of Presentation
  Prague,Czech Republic
- Year and Date
  2015-05-20
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09688
[Presentation] Early Detection of Pediatric Idiopathic Pulmonary Arterial Hypertension by School Electrocardiography Screening : a Nationwide Survey in Japan2013
- Author(s)
  Sawada H, Mitani Y, Nakayama T, Fukushima H, Kogaki S, Igarashi T, Ichida F, Ono Y, Nakanishi T, Doi S, Ishikawa S, Matsushima M, Yamada O and Saji T.
- Organizer
  American Heart Association
- Place of Presentation
  Dallas,USA
- Year and Date
  2013-11-20
- Data Source
  KAKENHI-PROJECT-23591565
[Presentation] Marlene Rabinovitch肺高血圧において、BMPR2減少から炎症細胞浸潤に至る機序2013
- Author(s)
  澤田博文、三谷義英、大槻祥一郎、淀谷典子、大橋啓之、丸山一男、駒田美弘
- Organizer
  第2回日本肺循環学会シンポジウム『肺高血圧発症の分子生物学的アプローチ』
- Place of Presentation
  東京
- Year and Date
  2013-06-22
- Data Source
  KAKENHI-PROJECT-23591565
[Presentation] Reduced BMPR-II Induces GM-CSF Translation and Macrophage Recruitement in Human and Mice, Exacerbating Pulmonary Hypertension.2013
- Author(s)
  Hirofumi Sawada, Yoshihide Mitani, Noriko Yodoya, Shoichiro Otsuki1, Hiroyuki Ohashi, Kazuo Maruyama, Yoshihiro Komada, Marlene Rabinovitch.
- Organizer
  第２回日本肺循環学会
- Place of Presentation
  Tokyo
- Invited
- Data Source
  KAKENHI-PROJECT-24591574
[Presentation] Early detection of pediatric idiopathic pulmonary arterial hypertension by school electrocardiography screening: a nationwide survey in Japan.2013
- Author(s)
  Sawada H, Mitani Y, Nakayama T, Fukushima H, Kogaki S, Igarashi T, Ichida F, Ono Y, Nakanishi T, Doi S, Ishikawa S, Matsushima M, Yamada O, Saji T.
- Organizer
  American Heart Association
- Place of Presentation
  米国
- Data Source
  KAKENHI-PROJECT-24591574
[Presentation] Phenotypic Modulation of Smooth Muscle Cells and Related Inflammation in the Development of Experimental Obstructive Pulmonary Vasculopathy in Rats2013
- Author(s)
  Otsuki S, Sawada H, Yodoya N, Shinohara T, Kato T, Ohashi H, Imanaka K, Shimpo H, Zhang E, Maruyama K, Komada Y, Mitani Y.
- Organizer
  American Heart Association
- Place of Presentation
  Dallas, USA
- Year and Date
  2013-11-17
- Data Source
  KAKENHI-PROJECT-23591565
[Presentation] 従圧式人工呼吸におけるVILIラットモデルの作成2013
- Author(s)
  山田康晴、丸山淳子、張　尓泉、上野浩明、小林　睦、岩下義明、横地　歩、澤田博文、大元文香、原田慎一、陳　通、南波里奈、今井　寛、丸山一男
- Organizer
  第35回日本呼吸療法医学会学術総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24592333
[Presentation] Phenotypic Modulation of Smooth Muscle Cells and Related Inflammation in the Development of Experimental Obstructive Pulmonary Vasculopathy in Rats.2013
- Author(s)
  Otsuki S, Sawada H, Yodoya N, Shinohara T, Kato T, Ohashi H, Zhang E, Yoshida-Imanaka K, Shimpo H, Maruyama K, Komada Y, Mitani Y.
- Organizer
  American Heart Association
- Place of Presentation
  米国
- Invited
- Data Source
  KAKENHI-PROJECT-24591574
[Presentation] Marlene Rabinovitch. Reduced BMPR-II Induces GM-CSF Translation by Impaired Stress Granule Response, Exacerbating Pulmonary Hypertension2012
- Author(s)
  澤田博文、三谷義英、大槻祥一郎、淀谷典子、大橋啓之、丸山一男、駒田美弘
- Organizer
  第76回日本循環器学会学術集会シンポジウム『肺高血圧治療の最前線』
- Place of Presentation
  福岡
- Year and Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-23591565
[Presentation] Reduced BMPR-II Induces GM-CSF Translation by Impaired Stress Granule Response, Exacerbating Pulmonary Hypertension2012
- Author(s)
  澤田　博文
- Organizer
  日本循環器学会学術集会　シンポジウム
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-23591565
[Presentation] Role of endogenous bone marrow-derived stem cells and its pharmacological modulation in pulmonary arterial hypertension in mice: a new mechanism of action in bosentan therapy.2012
- Author(s)
  Taichi Kato, Hirofumi Sawada, Hiroyuki Ohashi, Shoichiro Otsuki, Noriko Yodoya, Hideto Shimpo, Yoshihiro Komada, Yoshihide Mitani.
- Organizer
  American Heart Association
- Place of Presentation
  LA
- Data Source
  KAKENHI-PROJECT-24591574
[Presentation] Public access defibrillation improved the outcome after out-of-hospital cardiac arrests in school-age children: a nationwide, population-based, Utstein registry study in Japan2012
- Author(s)
  Yoshihide Mitani, Kunio Ohta, Noriko Yodoya, Shoichiro Otsuki, Hiroyuki Ohashi, Hirofumi Sawada, Masami Nagashima, Naokata Sumitomo, Yoshihiro Komada,
- Organizer
  American Heart Association
- Place of Presentation
  LA
- Data Source
  KAKENHI-PROJECT-24591574
[Presentation] Reduced BMPR-II Increases GM-CSF mRNA Translation by Inhibiting eIF2a-Mediated Stress Granule Formation and Propensity to Pulmonary Vascular Disease2011
- Author(s)
  Sawada H、Alastalo TP, Glotzbach JP, Chan R, Fuchs G, Januszyk M, Lai YJ, Perez VDJ, Kim YM, Wang L, Saito T, Spiekerkoetter E, Gurtner GC, Sarnow P and Rabinovitch M.
- Organizer
  AHA Scientific Session 20113CPR Cournand & Comroe Young Investigator Award Competition
- Place of Presentation
  Orlando, USA
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-23591565
[Presentation] Reduced BMPR2 increases GM-CSF mRNA translation by inhibiting eIF2α mediated stress granule formation and propensity to pulmonary vascular disease.2011
- Author(s)
  Hirofumi Sawada
- Organizer
  American Heart Association Scientific Session 20111
- Place of Presentation
  Orlando, FL, USA
- Data Source
  KAKENHI-PROJECT-23591565
[Presentation] Chronic hypoxia increases bone marrow-derived endothelial cells of non-hematopoietic stem cell origin, as well as macrophages of hematopoietic stem cell origin, in pulmonary vascular. lesions in mice : differential roles of bone marrow-derived hematopoietic and non-hematopoietic stem cells in pulmonary hypertension2008
- Author(s)
  Kato T, Sawada H, Maruyama J, Masuya M, Mityata E, Nakamura S, Ikeyama Y, Shimpo H, Maruyama K, Komada Y, Mitani Y.
- Organizer
  American Heart Association
- Place of Presentation
  New Orleans, USA
- Year and Date
  2008-11-10
- Data Source
  KAKENHI-PROJECT-19591202
[Presentation] Macitentan Reverses Early Obstructive Pulmonary Vasculopathy in Rats: Early Intervention in Overcoming the Survivin-mediated Resistance to Apoptosis
- Author(s)
  Shinohara T., Sawada H., Otsuki S., Yodoya N., Kato T., Ohashi H., Zhang E., Saitoh S., Shimpo H., Maruyama K., Komada Y., Mitani Y.
- Organizer
  Association for European Pediatric and Congenital Cardiology
- Place of Presentation
  Peague, Czech Republic
- Year and Date
  2015-05-20 – 2015-05-23
- Invited
- Data Source
  KAKENHI-PROJECT-24591574

1. YOSHIHIDE Mitani (60273380)

# of Collaborated Projects: 17 results

# of Collaborated Products: 58 results
2. KAZUO Maruyama (20181828)

# of Collaborated Projects: 15 results

# of Collaborated Products: 46 results
3. 西村有平 (30303720)

# of Collaborated Projects: 6 results

# of Collaborated Products: 2 results
4. MARUYAMA Junko (50263017)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
5. ZHANG Erquan (30456727)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
6. YOKICHI Ayumu (60359768)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. Yodoya Noriko (40525367)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. HIDETO Shimpo (70179076)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. 田中利男 (00135443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 大橋啓之 (70397511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 鳥羽修平 (20806111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. KATO Taichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 市田蕗子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 太田邦雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 川合真子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sawada Hirofumi 澤田 博文

SAWADA Hirofumi 澤田 博文

澤田 博文 サワダ ヒロフミ

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病変形成機序に基づく肺高血圧の新規治療標的の開発Principal Investigator

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Role of BMPR2 mutation in Pulmonary Hypertension in RatsPrincipal Investigator

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Role of inflammatory mechanism in the experimental model of pulmonary arterial hypertensionPrincipal Investigator

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Sawada Hirofumi 澤田博文

SAWADA Hirofumi 澤田博文

澤田博文サワダヒロフミ

[Book] PULMONARY　HYPERTENSION　　4. Nitric oxide in pathophysiology and treatment of pulmonary hypertension2013