Heissig Beate ハイジッヒベアーテ

… Alternative Names

HEISSIG Beate ハイジッヒベアーテ

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Researcher Number	30372931
Other IDs	https://orcid.org/0000-0002-0348-5934
Affiliation (Current)	2024: 順天堂大学, 大学院医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 順天堂大学, 大学院医学研究科, 特任准教授 2021: 順天堂大学, 医学(系)研究科(研究院), 准教授 2019 – 2020: 順天堂大学, 医学(系)研究科(研究院), 特任准教授 2012 – 2018: 東京大学, 医科学研究所, 准教授 2014: 東京大学, 医科学研究所, 特任准教授 … More 2009 – 2011: The University of Tokyo, 医科学研究所, 特任准教授 2008: The University of Tokyo, 医科学研究所, 特任助教授 2007: The University of Tokyo, 医科学研究所, 産学官連携研究員特任助教 2006: 東京大学, 医科学研究所, 助手 2006: 順天堂大学, 医学部, 講師 2006: Juntendo University, School of Medicine, Assistant Professor, 大学院医学研究科, 講師 2005: 順天堂大学, 大学院・医学研究科, 講師 Less
Review Section/Research Field	Principal Investigator Hematology / Biological Sciences / Basic Section 54010:Hematology and medical oncology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 54010:Hematology and medical oncology-related / Biological Sciences Except Principal Investigator General surgery / Biological Sciences
Keywords	Principal Investigator マトリックスメタロプロテイナーゼ / 血管新生 / Kit-ligand / プラスミン / ケモカイン / 血管新生因子 / 顆粒球コロニー刺激因子 / プラスミノーゲンアクチベータ受容体 / プラスミノーゲン / 細胞・組織 … More / 酵素 / 骨髄由来細胞 / 細胞外ドメイン分泌 / 骨髄細胞 / トロンボポイエチン / 血管内皮増殖因子 / multiple myeloma / angiogenesis / plasmin / HIF-1 / 生体・分子 / 細胞浸潤 / プロセシング / 微小環境 / リンパ腫 / 血液線維素溶解系 / 生体分子 / 細胞分化 / 線維素溶解系 / マトリックスメタロプテイナーゼ / アデノウィルスベクター / Egfl7 / drug resistance / Leukemia / protein fragment / fibrinolysis / adhesion / ITGB3 / KLF2 / cell growth / integrins / cancer / notch receptor / myltiple myeloma / integrin / proliferation / angiocrine factor / 幹細胞 / hematopoiesis / fibrinolytic factors / mesenchymal stem cells / stem cells / 間葉系幹細胞 / differentiation / mobilization / G-CSF / matrix metalloproteinase / plasminogen activator / plasminogen / 抗癌剤 / 放射線 / プラスミノーゲンアクチベータ / 細胞動員 / マトリックスメタロプロテイナ / プラスミノーゲンアクチベータ受容 / PAI-1阻害剤 / FIH-1 / 遺伝子発現 / CXCL12 / 発言制御 / 発現制御 / セリンプロテアーゼ / PAI-1 / 造血因子 / 発生・分化 / がん / 虚血性壊死 / tPA / マサリックスメタロプロテイナーゼ / 凝固・線溶 / 癌 / サイトカインプロセシング / 血小板 / ストローマ細胞 / サイトカイン / 組織型プラスミノーゲンアクチベーター / 血管新生ニッチ / アディポジェネシス / ADAM17 / ADAM12 / ヘマンジオサイト / マトリックスメタロブロテイナーゼ … More Except Principal Investigator 潰瘍性大腸炎 / TNFα / プラスミン阻害剤 / 線維素溶解系 / マトリックスメタロプロテイナーゼ / 炎症性腸疾患 / 炎症性サイトカイン / プラスミン / 好中球エラスターゼ / マトリックスメタロプロテアーゼ / 血液線維素溶解系 / IBD / クローン病 / 炎症性大腸炎 / ゲノム医学 / リンパ管新生 / 血管新生 / 転移 / がん浸潤 / がん微小環境 / ゲノム科学 / 生体イメージング / 生体材料 / シグナル伝達 / 微小環境 Less

Role of Slc5a5 in the diagnosis and treatment of drug-resistant cancerPrincipal Investigator
- Principal Investigator
  
  ハイジッヒベアーテ
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Juntendo University
Elucidation of pathological control mechanism of multiple myeloma by tPA/tPA receptor signalingPrincipal Investigator
- Principal Investigator
  
  ハイジッヒベアーテ
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
tPA/tPA受容体シグナルによる多発性骨髄腫の病態制御機構の解明Principal Investigator
- Principal Investigator
  
  ハイジッヒベアーテ
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
Role of the angiocrine factor Egfl7 in multiple myeloma progression and drug resistancePrincipal Investigator
- Principal Investigator
  
  Heissig Beate
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
Fibrinolytic factors control MSC expansion thereby enhancing hematopoiesisPrincipal Investigator
- Principal Investigator
  
  Heissig Beate
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Studies in the action mechanism of fibrinolytic system on the inflammatory bowel disease and its clinical applications
- Principal Investigator
  
  Komiyama Hiromitsu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Juntendo University
Multifunctional role of Membrane-type 1 matrix metalloproteinase in multiple myelomaPrincipal Investigator
- Principal Investigator
  
  HEISSIG Beate
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Integrative Research on Cancer Microenvironment Network
- Principal Investigator
  
  MIYAZONO Kohei
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Functional analysis of the fibrinolytic system in bone marrow-derived cell mediated tumor angiogenesis and growthPrincipal Investigator
- Principal Investigator
  
  HEISSIG Beate
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
The role of plasmin in the regulation of the multiple myeloma microenvironmentPrincipal Investigator
- Principal Investigator
  
  HEISSIG Beate
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
血管内皮細胞由来因子EGFL7のがん血管新生における機能解析Principal Investigator
- Principal Investigator
  
  HEISSIG Beate
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
新しい血管内皮細胞由来因子EGFL7のがん血管新生における機能解析Principal Investigator
- Principal Investigator
  
  HEISSIG Beate
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
脂肪細胞ニッチにおけるADAMsプロテイナーゼの機能的解析Principal Investigator
- Principal Investigator
  
  HEISSIG Beate
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
線溶系酵素群による骨髄内ニッチ制御機構Principal Investigator
- Principal Investigator
  
  HEISSIG Beate
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Role of fibrinolytic factors in the regulation of hematopoiesisPrincipal Investigator
- Principal Investigator
  
  BEATE Heissig
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Juntendo University

[Book] 実験医学増刊　Vol.33 No.5 （がん微小環境と標的治療）2015
- Author(s)
  ハイジッヒ・ベアテ、服部浩一
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PLANNED-22112007
[Book] 実験医学増刊　Vol.33 No.5 （がん微小環境と標的治療）2015
- Author(s)
  ハイジッヒ・ベアテ、服部浩一
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24591382
[Journal Article] The role of plasminogen/plasmin system in inflammation of oral cavity2023
- Author(s)
  Yatsenko T, Skrypnyk M, Toroyanovska O, Tobita M, Osada T, Takahashi S, Hattori K, and Heissig B
- Journal Title
  
  Cells
  
  Volume: 12 Issue: 3 Pages: 445-445
- DOI
  10.3390/cells12030445
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08404, KAKENHI-PROJECT-21K08692, KAKENHI-PROJECT-22K07206, KAKENHI-PROJECT-22KF0337
[Journal Article] アンジオクラインシステムによるがん増殖制御機構2022
- Author(s)
  服部浩一、島津浩、高橋聡、Heissig Beate
- Journal Title
  
  日本血栓止血学会雑誌
  
  Volume: 33 Pages: 314-320
- Data Source
  KAKENHI-PROJECT-22KF0337
[Journal Article] COVID-19 severity and thrombo-inflammatory response linked to ethnicity2022
- Author(s)
  Heissig B, Salama Y, Vehreschild JJ, Vehreschild MJGT, Mori H, Adachi E, Jakob C, Tabe Y, Ruethrich M, Borgmann S, Naito T, Wille K, Valenti S, Hower M, Hattori N, Rieg S, Nagaoka T, Jensen BE, Yotsuyanagi H, Hertenstein B, Ogawa H, Kominami E, Roemmele C, Takahashi S, Rupp J, Takahashi K, Hanses F, Hattori K
- Journal Title
  
  Biomedicines
  
  Volume: 10 Issue: 10 Pages: 2549-2549
- DOI
  10.3390/biomedicines10102549
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08404, KAKENHI-PROJECT-21K08692, KAKENHI-PROJECT-22K07206, KAKENHI-PROJECT-22KF0337
[Journal Article] YO2 induces melanoma cell apoptosis through p53-mediated LRP1 downregulation2022
- Author(s)
  Salama Y, Takahashi S, Tsuda Y, Okada Y, Hattori K, and Heissig B
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 1 Pages: 288-288
- DOI
  10.3390/cancers15010288
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08404, KAKENHI-PROJECT-21K08692, KAKENHI-PROJECT-22K07206, KAKENHI-PROJECT-22KF0337
[Journal Article] siRNA against CD40 delivered via a fungal recognition receptor ameliorates murine acute graft-versus-host disease2022
- Author(s)
  Heissig B, Salama Y, Tateno M, Takahashi S and Hattori K
- Journal Title
  
  EJHaem
  
  Volume: 3 Issue: 3 Pages: 849-861
- DOI
  10.1002/jha2.439
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08404, KAKENHI-PROJECT-21K08692, KAKENHI-PROJECT-22K07206, KAKENHI-PROJECT-22KF0337
[Journal Article] サイトカインストーム関連疾患に対する新規分子標的としての血液線維素溶解系因子群2022
- Author(s)
  服部浩一、島津浩、高橋聡、Heissig Beate
- Journal Title
  
  臨床血液
  
  Volume: 63 Pages: 403-409
- Data Source
  KAKENHI-PROJECT-22KF0337
[Journal Article] The multifacted role of plasminogen in Cancer.2021
- Author(s)
  Heissig B*, Salama Y, Osada T, Okumura K, Hattori K.
- Journal Title
  
  Intern. J of Molecular Sciences
  
  Volume: 22(5) Issue: 5 Pages: 2304-2304
- DOI
  10.3390/ijms22052304
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08857, KAKENHI-PROJECT-18K08657, KAKENHI-PROJECT-19K08858, KAKENHI-PROJECT-21K08404, KAKENHI-PROJECT-21K08692
[Journal Article] The multifaceted roles of EGFL7 in cancer and drug resistance.2021
- Author(s)
  Heissig B*, Salama Y, Takahashi S, Okumura K, Hattori K
- Journal Title
  
  Cancers
  
  Volume: 13(5) Issue: 5 Pages: 1014-1014
- DOI
  10.3390/cancers13051014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08857, KAKENHI-PROJECT-18K08657, KAKENHI-PROJECT-19K08858, KAKENHI-PROJECT-21K08404, KAKENHI-PROJECT-21K08692
[Journal Article] Aloysia Citrodora Essential Oil Inhibits Melanoma Cell Growth and Migration by Targeting HB-EGF-EGFR Signaling2021
- Author(s)
  Salama Yousef、Jaradat Nidal、Hattori Koichi、Heissig Beate
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 15 Pages: 8151-8151
- DOI
  10.3390/ijms22158151
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08857, KAKENHI-PROJECT-21K08404
[Journal Article] The EGFL7-ITGB3-KLF2 axis enhances survival of multiple myeloma in preclinical models.2020
- Author(s)
  Salama Y, Andries H, Yokoyama K, Takahashi S Hattori K and Heissig B,.
- Journal Title
  
  Blood Adv
  
  Volume: in press Issue: 6 Pages: 1021-1037
- DOI
  10.1182/bloodadvances.2019001002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08657, KAKENHI-PROJECT-19K08858, KAKENHI-PROJECT-19K16605, KAKENHI-PROJECT-17K09941, KAKENHI-PROJECT-19K08857
[Journal Article] Low-dose oral cyclophosphamide therapy reduces atherosclerosis progression by decreasing inflammatory cells in a murine model of atherosclerosis.2020
- Author(s)
  Sato-Okabayashi Y,Isoda K.Heissig B,Kadoguchi T,Akita K,　Kitamura K,Shimada K,Hattori K, Daida H.
- Journal Title
  
  Int J Cardiol Heart Vasc
  
  Volume: May 10; 28 Pages: 100529-100529
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08857
[Journal Article] The multifaceted role of plasminogen in inflammation2020
- Author(s)
  Heissig Beate、Salama Yousef、Takahashi Satoshi、Osada Taro、Hattori Koichi
- Journal Title
  
  Cellular Signalling
  
  Volume: 75 Pages: 109761-109761
- DOI
  10.1016/j.cellsig.2020.109761
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08657, KAKENHI-PROJECT-19K08857
[Journal Article] The fibrinolytic factor tPA drives LRP1-mediated melanoma growth and metastasis2019
- Author(s)
  Salama Y, Lin SY, Dhahri D, Hattori K, Heissig B
- Journal Title
  
  FASEB J
  
  Volume: 33 Issue: 3 Pages: 3465-3480
- DOI
  10.1096/fj.201801339rrr
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09821, KAKENHI-PROJECT-16K09866, KAKENHI-PROJECT-18K08657, KAKENHI-PROJECT-19K08858, KAKENHI-PROJECT-17K09941
[Journal Article] Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice.2017
- Author(s)
  Honjo K, Munakata S, Tashiro Y, Salama Y, Shimazu H, Eiamboonsert S, Dhahri D, Ichimura A, Dan T, Miyata T, Takeda K, Sakamoto K, Hattori K, Heissig B.
- Journal Title
  
  FASEB Journal
  
  Volume: - Issue: 6 Pages: 2625-2637
- DOI
  10.1096/fj.201600871rr
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05652, KAKENHI-PROJECT-26461415, KAKENHI-PROJECT-16K09821, KAKENHI-PROJECT-15K21373, KAKENHI-PROJECT-16K19956, KAKENHI-PROJECT-16K10476, KAKENHI-PROJECT-17K09941
[Journal Article] The role of plasmin in the pathogenesis of murine multiple myeloma2017
- Author(s)
  Eiamboonsert S, Salama Y, Watarai H, Dhahri D, Tsuda Y, Okada Y, Hattori K, Heissig B.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 488 Issue: 2 Pages: 387-392
- DOI
  10.1016/j.bbrc.2017.05.062
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08333, KAKENHI-PROJECT-16K09821, KAKENHI-PROJECT-16K09866, KAKENHI-PROJECT-17K09941, KAKENHI-PROJECT-16K14591
[Journal Article] Pharmacological targeting of plasmin prevents lethality and tissue damage in a murine model of macrophage activation syndrome2017
- Author(s)
  1.Shimazu H, Munakata S, Tashiro Y, Salama Y, Eiamboonser S, Ohta Y, Onoda H, Tsuda Y, Okada Y, Nakauchi H, Heissig B and Hattori K
- Journal Title
  
  Blood
  
  Volume: 印刷中 Issue: 1 Pages: 59-72
- DOI
  10.1182/blood-2016-09-738096
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461415, KAKENHI-PROJECT-16K09821, KAKENHI-PROJECT-16K19956, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16K08333, KAKENHI-PROJECT-16K09866, KAKENHI-PROJECT-17K09941, KAKENHI-PROJECT-16H02661, KAKENHI-PROJECT-15K21373
[Journal Article] Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice.2017
- Author(s)
  Honjo K, Shinya Munakata S, Tashiro Y, Salama Y, Shimazu H, Eiamboonsert S, Dhahri D, Ichimura A, Dan T, Miyata T, Takeda K, Sakamoto K, Hattori K, Heissig B.
- Journal Title
  
  FASEB J
  
  Volume: 31 Pages: 2625-2637
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09821
[Journal Article] The angiogenic factor Egfl7 alters thymogenesis by activating Flt3 signaling2017
- Author(s)
  Salama Yousef、Hattori Koichi、Heissig Beate
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 490 Issue: 2 Pages: 209-216
- DOI
  10.1016/j.bbrc.2017.06.023
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09821, KAKENHI-PROJECT-16K09866, KAKENHI-PROJECT-17K09941
[Journal Article] Fibrinolytic crosstalk with endothelial cells expands murine mesenchymal stromal cells2016
- Author(s)
  Dhahri D, Sato-Kusubata K, Ohki-Koizumi M, Nishida C, Tashiro Y, Munakata S, Shimazu H, Salama Y, Eiamboonsert S, Nakauchi H, Hattori K and Heissig B
- Journal Title
  
  Blood
  
  Volume: 128 Pages: 1063-75
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09821
[Journal Article] Cancer therapy targeting the fibrinolytic system2016
- Author(s)
  Heissig B, Eiamboonsert S, Salama Y, Shimazu H, Dhahri D, Munakata S Tashiro Y and Hattori K
- Journal Title
  
  Advanced Drug Delivery Rev
  
  Volume: 印刷中 Pages: 172-179
- DOI
  10.1016/j.addr.2015.11.010
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461415, KAKENHI-PROJECT-15K21373, KAKENHI-PROJECT-25461961
[Journal Article] Role of mesenchymal stem cell-derived fibrinolytic factor in tissue regeneration and cancer progression.2015
- Author(s)
  Heissig B, Dhahri D, Eiamboonsert S, Salama Y, Shimazu H, Munakata S, Hatttori K.
- Journal Title
  
  Cellular and molecular life sciences
  
  Volume: 72(24) Issue: 24 Pages: 4759-4770
- DOI
  10.1007/s00018-015-2035-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461961
[Journal Article] Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking.2015
- Author(s)
  A Sato, C Nishida, K Sato-Kusubata, M Ishihara, Y Tashiro, I Gritli, H Shimazu, S Munakata, H Yagita, K Okumura, Y Tsuda, Y Okada, A Tojo, H Nakauchi, S Takahashi, B Heissig and K Hattori
- Journal Title
  
  Leukemia
  
  Volume: 29 Issue: 1 Pages: 145-56
- DOI
  10.1038/leu.2014.151
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22112007, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24591382, KAKENHI-PROJECT-25460164, KAKENHI-PROJECT-25861215
[Journal Article] Inhibition of Plasmin Protects Against Colitis in Mice by Suppressing Matrix Metalloproteinase 9-Mediated Cytokine Release From Myeloid Cells.2015
- Author(s)
  Munakata S, Tashiro Y, Nishida C, Sato A, Komiyama H, Shimazu H, Dhahri D, Salama Y, Eiamboonsert S, Takeda K, Yagita H, Tsuda Y, Okada Y, Nakauchi H, Sakamoto K, Heissig B, Hattori K.
- Journal Title
  
  Gastroenterology
  
  Volume: 148 Issue: 3 Pages: 565-78
- DOI
  10.1053/j.gastro.2014.12.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22112007, KAKENHI-PROJECT-24591382, KAKENHI-PROJECT-25460164, KAKENHI-PROJECT-25461961, KAKENHI-PROJECT-25861215, KAKENHI-PROJECT-26461415, KAKENHI-PROJECT-26462025, KAKENHI-PROJECT-26462136, KAKENHI-PROJECT-25462068
[Journal Article] Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells.2014
- Author(s)
  Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, Matsukawa T, Kagiyama Y, Enomoto Y, Kawabata KC, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Heissig B, Hattori K, Kitamura T.
- Journal Title
  
  Blood
  
  Volume: 123(25) Issue: 25 Pages: 3932-42
- DOI
  10.1182/blood-2013-01-476747
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J09414, KAKENHI-PLANNED-22112007, KAKENHI-ORGANIZER-22118001, KAKENHI-PLANNED-22118002, KAKENHI-PROJECT-23249051, KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-24249039, KAKENHI-PROJECT-24591382, KAKENHI-PROJECT-24591398, KAKENHI-PUBLICLY-25118716, KAKENHI-PROJECT-25461422, KAKENHI-PROJECT-25860521, KAKENHI-PROJECT-26293231, KAKENHI-PROJECT-26461415
[Journal Article] Bonemarrow-derived CD11b+Jagged-2+ cells promote epithelial to mesenchymal transition and metastization in colorectal cancer.2013
- Author(s)
  Caiado F, Carvalho T, Rosa I, Remedio L, Costa A, Matos J, Heissig B, Yagita H, Hattori K, da Silva JP, Fidalgo P, Dias Pereira A, Dias S.
- Journal Title
  
  Cancer Res.
  
  Volume: 73 Issue: 14 Pages: 4233-46
- DOI
  10.1158/0008-5472.can-13-0085
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22112007, KAKENHI-PROJECT-23591371
[Journal Article] Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice2012
- Author(s)
  Yoshihiko Tashiro, Chiemi Nishida, Kaori Sato-Kusubata, Makiko Ohki-Koizumi, Makoto Ishihara, Aki Sato, Ismael Gritli, Hiromitsu Komiyama, Yayoi Sato, Yuichi Tomiki, Hirokazu Sakamoto, Takashi Dan, Toshio Miyata, Ko Okumura, Hiromitsu Nakauchi, Koichi Hattori, and Beate Heissig
- Journal Title
  
  Blood
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21591193
[Journal Article] Plasminogen deficiency attenuates postnatal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis2012
- Author(s)
  Okaji Y, Tashiro Y, Gritli I, Nishida C, Sato A, Ueno Y, Del Canto Gonzalez S, Ohki-Koizumi M, Akiyama H, Nakauchi H
- Journal Title
  
  Experimental hematology
  
  Volume: 40 Issue: 2 Pages: 143-154
- DOI
  10.1016/j.exphem.2011.10.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J00480, KAKENHI-PROJECT-21591193, KAKENHI-PROJECT-21591234, KAKENHI-PUBLICLY-22019006, KAKENHI-PUBLICLY-22021013, KAKENHI-ORGANIZER-22112001, KAKENHI-PLANNED-22112007, KAKENHI-PUBLICLY-23013009, KAKENHI-PROJECT-23591371
[Journal Article] MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemo-/cytokine gene transcription within niche cells2012
- Author(s)
  Chiemi Nishida, Kaori Kusubata, Yoshihiko Tashiro, Ismael Gritli, Aki Sato, Makiko Ohki-Koizumi, Yohei Morita, Makoto Nagano, Takeharu Sakamoto, Naohiko Koshikawa, Takahiro Kuchimaru, Shinae Kizaka-Kondoh, Motoharu Seiki, Hiromitsu Nakauchi, Koichi Hattori, and Beate Heissig
- Journal Title
  
  Blood
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21591193
[Journal Article] Plasmin inhibitor reduces lymphoid tumor growth by suppressing matrixmetallproteinase-9 dependent CD11b+/F4/80+ myeloid cell recruitment2012
- Author(s)
  Ishihara M, Heissig B, Nishida C, Rosenkvist J, Tashiro Y, Ohki M, Wanaka K, Tsuda Y, Okada Y, Nakauchi H, Hattori K
- Journal Title
  
  Leukemia
  
  Volume: 26 Issue: 2 Pages: 332-339
- DOI
  10.1038/leu.2011.203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J00480, KAKENHI-PROJECT-21249059, KAKENHI-PROJECT-21591193, KAKENHI-PROJECT-21591234, KAKENHI-PUBLICLY-22019006, KAKENHI-PUBLICLY-22021013, KAKENHI-PLANNED-22112007, KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-22590111, KAKENHI-PUBLICLY-23013009, KAKENHI-PROJECT-23591371, KAKENHI-PROJECT-23701090, KAKENHI-PUBLICLY-22117506
[Journal Article] New functions of the fibrinolytic system in bone marrow cell-derived angiogenesis2012
- Author(s)
  Beate Heissig, Makiko Ohki-Koizumi, Yoshihiko Tashiro, Ismael Gritli, Kaori Sato-Kusubata and Koichi Hattori
- Journal Title
  
  International Journal of Hematology
  
  Volume: 95 Issue: 2 Pages: 131-137
- DOI
  10.1007/s12185-012-1016-y
- NAID
  10030267151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591193, KAKENHI-PROJECT-21591234, KAKENHI-PUBLICLY-22019006, KAKENHI-PUBLICLY-22021013, KAKENHI-PLANNED-22112007, KAKENHI-PUBLICLY-23013009, KAKENHI-PROJECT-23591371
[Journal Article] Tumor necrosis receptor-associated factor(Traf) 2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease2011
- Author(s)
  Piao JH, Hasegawa M, Heissig B, Hattori K, Takeda K, Iwakura Y, Okumura K, Inohara N, Nakano H
- Journal Title
  
  J Biol Chem
  
  Volume: 151 Pages: 17879-17888
- URL
  http://www.jbc.org/content/by/year
- Data Source
  KAKENHI-PROJECT-21591193
[Journal Article] Role of Neutrophil-derived matrix metalloproteinase-9 for tissue regeneration2010
- Author(s)
  Heissig B, Nishida C, Tashiro Y, Sato Y, Ishihara M, Ohki M, Hattori K
- Journal Title
  
  Histology & Histopathology
  
  Volume: 25 Pages: 765-770
- Data Source
  KAKENHI-PROJECT-21591193
[Journal Article] Role of Neutrophil-derived matrix metalloproteinase-9 for tissue regeneration2010
- Author(s)
  Heissig Beate
- Journal Title
  
  Histology & Histopathology
  
  Volume: 26 Pages: 765-770
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591193
[Journal Article] Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration2010
- Author(s)
  Ohki M, Ohki Y, Ishihara M, Rosenkvist J, Gritli I, Tashiro Y, Akiyama H, Komiyama H, Lund LR, Nitta A, Yamada K, Zhu Z, Ogawa H, Yagita H, Okumura K, Nakauchi H, Werb Z, Hattori K, Heissig B
- Journal Title
  
  Blood
  
  Volume: 115 Pages: 4302-4312
- URL
  http://bloodjournal.hematologylibrary.org/search
- Data Source
  KAKENHI-PROJECT-21591193
[Journal Article] Role of Neutrophil-derived matrix metalloproteinase-9 for tissue regeneration2010
- Author(s)
  Heissig Beate
- Journal Title
  
  Histology & Histopathology
  
  Volume: 26 Pages: 765-770
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22112007
[Journal Article] Adipocyte-derived microvesicles are associated with multiple angiogenic factors and induce angiogenesis in vivo and in vitro.2010
- Author(s)
  Aoki N, Heissig, B, et al.
- Journal Title
  
  Endocrinology
  
  Volume: 151 Pages: 2567-2576
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22112001
[Journal Article] Role of Neutrophil-derived matrix metalloproteinase-9 for tissue regeneration2010
- Author(s)
  Heissig Beate
- Journal Title
  
  Histology & Histopathology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591193
[Journal Article] Role of Neutrophil-derived matrix metalloproteinase-9 for tissue regeneration2010
- Author(s)
  Heissig Beate
- Journal Title
  
  Histology & Histopathology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013013
[Journal Article] Adipocyte-Derived Microvesicles Are Associated with Multiple Angiogenic Factors and Induce Angiogenesis in Vivo and inVitro2010
- Author(s)
  Aoki N., Yokoyama R., Asai N., Ohki M., Ohki Y., Kusubata K., Heissig B., Hattori K., Nakagawa Y., and Matsuda T.
- Journal Title
  
  Endocrinology
  
  Volume: 151 Pages: 2567-2567
- URL
  http://endo.endojournals.org/content/by/year
- Data Source
  KAKENHI-PROJECT-21591193
[Journal Article] Contribution of the Fibrinolytic Pathway to Hematopoietic Regeneration2009
- Author(s)
  Heissig Beate
- Journal Title
  
  Journal of Cell Physiology 221
  
  Pages: 521-525
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013013
[Journal Article] Contribution of the Fibrinolytic Pathway to Hematopoietic Regeneration2009
- Author(s)
  Heissig Beate
- Journal Title
  
  Journal of Cell Physiology 221
  
  Pages: 521-525
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591193
[Journal Article] Contribution of the Fibrinolytic Pathway to Hematopoietic Regeneration2009
- Author(s)
  Heissig B, Ohki M, Ishihara M, Tashiro Y, Nishida C, Gritli I, Rosenkvist J, Hattori K
- Journal Title
  
  Journal of Cell Physiology
  
  Volume: 221(3) Pages: 51-5
- Data Source
  KAKENHI-PROJECT-21591193
[Journal Article] Targeted deletion of matrix metalloproteinase-9 reduces neutrophil accumulation during G-CSF-induced neoangiogenesis2009
- Author(s)
  Sato Y, Ohki Y, Akiyama H, Rosenkvist J, Gritli I, Okumura K, Ogawa H, Heissig B, Hattori K, Ohsaka A
- Journal Title
  
  Cytometry Res
  
  Volume: 19(2) Pages: 53-62
- NAID
  10026084473
- Data Source
  KAKENHI-PROJECT-21591193
[Journal Article] Novel functions for a fibrinolytic pathway in controlling hematopoiesis2007
- Author(s)
  Heissig B, et. al.
- Journal Title
  
  Cell Stem Cell 1
  
  Pages: 658-670
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18060013
[Journal Article] Novel functions for a fibrinolytic pathway in controlling hematopoiesis2007
- Author(s)
  Heissig B, et. al.
- Journal Title
  
  Cell Stem Cell 1
  
  Pages: 658-670
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18013021
[Journal Article] Novel functions for a fibrinolytic pathway in controlling hematopoiesis2007
- Author(s)
  Heissig B, et. al.
- Journal Title
  
  Cell Stem Cell 1
  
  Pages: 658-670
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18052004
[Journal Article] Cytokine-mediated deployment of SDF-1 induces revascularisation through recruitment of CXCR4+ hemangiocytes.2006
- Author(s)
  Jin DK, Shido K, Kopp HG, Petit I, Shmelkov SV, Young LM, Hooper ATA, Amano H, Avecilla ST, Heissig B, Hattori K, Zhang F, Hicklin DJ, Wu Y, Zhu Z, Salari H, Werb Z, Hackett NR, Crystal RG, Lyden D, Raffi S.
- Journal Title
  
  Nat.Med.(Epub)(Erratum) 12(5), 12(8)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591011
[Journal Article] Increased soluble urokinase plasminogen activator receptor (suPAR) serum levels after granulocyte colony-stimulating factor treatment do not predict successful progenitor cell mobilization in vivo.2006
- Author(s)
  Fietz T, Hattori K, Thiel E, Heissig B.
- Journal Title
  
  Blood 107(8)
  
  Pages: 3408-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591011
[Journal Article] 「研究成果報告書概要(欧文)」より2005
- Author(s)
  Heissig B, Rafii S, Akiyama H, Ohki Y, Sato Y, Rafael T, Zhu Z, Hicklin DJ, Okumura K, Ogawa H, Werb Z, Hattori K.
- Journal Title
  
  J.Exp.Med. 202(6)
  
  Pages: 739-50
- Data Source
  KAKENHI-PROJECT-17591011
[Journal Article] A role for niches in hematopoietic cell development.2005
- Author(s)
  heissig Beate
- Journal Title
  
  Hematology 10
  
  Pages: 247-253
- Data Source
  KAKENHI-PROJECT-17591011
[Journal Article] Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9 mediated progenitor cell mobilization.2005
- Author(s)
  Heissig Beate
- Journal Title
  
  Journal of Experimental Medicine 202
  
  Pages: 739-750
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591011
[Journal Article] A role for niches in hematopoietic cell development.2005
- Author(s)
  Heissig Beate
- Journal Title
  
  Hematology 10
  
  Pages: 247-253
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591011
[Journal Article] 「研究成果報告書概要(欧文)」より2005
- Author(s)
  Heissig B, Ohki Y, Sato Y, Rafii S, Werb Z, Hattori K.
- Journal Title
  
  Hematology 10(3)
  
  Pages: 247-53
- Data Source
  KAKENHI-PROJECT-17591011
[Journal Article] Granulocyte colony-stimulating factor promotes neovascularization by releasing vascular endothelial growth factor from neutrophils.2005
- Author(s)
  Ohki Y, Heissig B, Sato Y, Akiyama H, Zhu Z, Hicklin DJ, Shimada K, Ogawa H, Daida H, Hattori K, Ohsaka A.
- Journal Title
  
  FASEB 19(14)
  
  Pages: 2005-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591011
[Patent] 炎症性疾患治療剤2011
- Inventor(s)
  服部浩一、津田裕子、ハイジッヒ・ベアテ
- Industrial Property Rights Holder
  学校法人神戸学院
- Filing Date
  2011-09-27
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] COVID-19後のプロテオリティック・ニッチにおける免疫系再構築機構の解明2023
- Author(s)
  服部浩一、高橋聡、長田太郎、Heissig Beate
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-22KF0337
[Presentation] ES特異的転写因子Zfp296の細胞がん化への関与2022
- Author(s)
  溝上優美、池田智美、池上貴子、服部浩一、Heissig Beate 小出寛
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22KF0337
[Presentation] サイトカインストーム症候群の病態解明と新規治療戦略2022
- Author(s)
  服部浩一、高橋聡、Heissig Beate
- Organizer
  第44回日本造血・免疫細胞療法学会
- Data Source
  KAKENHI-PROJECT-22KF0337
[Presentation] Biomarker and predictors of severe COVID-19:a comparative study of patients in Japan and Germany2022
- Author(s)
  Hattori K,Takahashi S,and Heissig Beate
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22KF0337
[Presentation] Health systems on the verge of collapse - what Japan and Germany can learn from each other in the wake of the COVID-19 pandemic2021
- Author(s)
  Beate Heissig
- Organizer
  International Medical Society of Japan
- Invited
- Data Source
  KAKENHI-PROJECT-19K08857
[Presentation] The fibrinolytic factor tPA drives LRP1-mediated melanoma growth and metastasis.2020
- Author(s)
  Beate Heissig
- Organizer
  American Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08857
[Presentation] The Fibrinolytic System Orchestrates the Development of Inflammation and Inflammation-Associated Carcinogenesis in the Proteolytic Niche2020
- Author(s)
  Heissig Beate
- Organizer
  Gordon Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08857
[Presentation] Fibrinolytic factors conrols MSC expansion2018
- Author(s)
  Salama Yousef, Heissig Beate
- Organizer
  平成29年度先端モデル動物支援プラットフォーム成果発表会
- Data Source
  KAKENHI-PROJECT-16K09821
[Presentation] Niche cells for tissue regeneration2018
- Author(s)
  Beate Heissig
- Organizer
  Joint Workshop between Norway and Japan in Regenerative Medicine
- Invited
- Data Source
  KAKENHI-PROJECT-16K09821
[Presentation] Dual or half career: trapped between success and support.2018
- Author(s)
  Heissig Beate
- Organizer
  European Research Nights
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09821
[Presentation] 1.The niche/microenvrionment shapes the fate of researchers and stem cells2016
- Author(s)
  Heissig Beate
- Organizer
  European Research Day
- Place of Presentation
  Delegation of the European Union to Japan, Tokyo
- Invited
- Data Source
  KAKENHI-PROJECT-16K09821
[Presentation] Fibrinolytic factors in stem cell regulation and cancer2016
- Author(s)
  Heissig Beate
- Organizer
  The 91th of Stem Cell Biology and Regenerative Medicine Forum
- Place of Presentation
  東京大学医科学研究所（東京都港区）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09821
[Presentation] Inflammatory bowel disease モデルにおける線溶系を介した抑制機序2015
- Author(s)
  宗像慎也,小見山博光，坂本一博,Heissig Beate,服部浩一
- Organizer
  お茶の水がん学アカデミア　第111回集会
- Place of Presentation
  東京,順天堂大学
- Year and Date
  2015-02-25
- Data Source
  KAKENHI-PROJECT-25461961
[Presentation] 腹腔内癒着における線溶系阻害因子PAI-1の機能解明2015
- Author(s)
  本庄薫平, 塚本亮一, 植山孝恵, 伊藤慎吾, 市川亮介, 呉一眞, 盧尚志, 田代良彦, 宗像慎也, 高橋玄, 小見山博光, 小島豊, 五藤倫敏, 冨木裕一, 市村敦彦, 段孝, 宮田敏男, Beate Heissig, 服部浩一, 坂本一博
- Organizer
  第115回日本外科学会定期学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-25461961
[Presentation] PAI-1阻害剤による血管新生及び組織再生促進療法．2013
- Author(s)
  宗像慎也，田代良彦，島津　浩，西田知恵美，イスマエルグリツリ，佐藤亜紀，小泉麻季子，楠畑かおり，小見山博光，坂本一博，宮田敏男，ハイジッヒベアテ，服部浩一
- Organizer
  第113回日本外科学会定期学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-25461961
[Presentation] PAI-1阻害剤による血管新生及び組織再生促進療法2013
- Author(s)
  田代良彦，宗像慎也，西田知恵美，石原誠人，Gritli Ismael，島津　浩，佐藤亜紀，楠畑かおり，小泉摩季子，小見山博光，坂本一博，宮田敏夫，中内啓光，Heissig Beate，服部浩一
- Organizer
  第113回日本外科学会定期学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-25461961
[Presentation] MT1-MMPRegulates Hematopoiesis Through HIF-Mediated2011
- Author(s)
  Chiemi Nishida, Kaori Kusubata, Yoshihiko Tashiro, Ismael Gritli, Aki Sato, Makiko Ohki-Koizumi, Motoharu Seiki, Hiromitsu Nakauchi, Beate Heissig and Koichi Hattori
- Organizer
  Chemo-/Cytokine Release From the Bone Marrow Niche 53回アメリカ血液学会
- Place of Presentation
  サンディエゴSan Diego Convention Center
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] 生体内細胞分化制御因子としてのMT1-MMPの機能解析2011
- Author(s)
  西田知恵美、楠畑かおり、田代良彦、清木元治、中内啓光、Heissig Beate、服部浩一
- Organizer
  第10回日本再生医療学会
- Place of Presentation
  京王プラザホテル.東京
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] The proteolytic bone marrow niche : The impact of membrane type-1 matrix metalloproteinase and plasminogen dificiency on hematopoiesis2011
- Author(s)
  Beate Heissig
- Organizer
  2011年度日独がんワークショップ
- Place of Presentation
  グランドプリンスホテル広島
- Year and Date
  2011-09-18
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] The proteolytic bone marrow niche : The impact of membrane type-1 matrix metalloproteinase and plasminogen dificiency on hematopoiesis2011
- Author(s)
  Beate Heissig
- Organizer
  2011年度日独がんワークショップ
- Place of Presentation
  グランドプリンスホテル広島(広島県)
- Year and Date
  2011-09-18
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] 線維素溶解系の活性化による骨髄内間葉系幹細胞の増殖2011
- Author(s)
  楠畑かおり、小泉摩希子、Heissig Beate、服部浩一
- Organizer
  第10回日本再生医療学会総会
- Place of Presentation
  京王プラザホテル東京
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] 線溶系因子プラスミンによる赤血球造血制御機構の解明2011
- Author(s)
  Yurai Okaji, Chiemi Nishida, Koichi Hattori, Beate Heissig
- Organizer
  ワークショップ「個体レベルのがん研究の魅力:培養細胞と臨床研究をつなぐマトリクス」
- Place of Presentation
  琵琶湖ホテル
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] Fibrinolytic factors regulate tumor progression and growth by altering the interaction between cells of the tumor microenvironment2011
- Author(s)
  Beate Heissig
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] The proteolytic bone marrow niche : The impact of membrane type-1 matrix metalloproteinase and plasminogen dificiency on hematopoiesis2011
- Author(s)
  Beate Heissig
- Organizer
  2011年度日独がんワークショップ
- Place of Presentation
  グランドプリンスホテル広島(広島県)
- Year and Date
  2011-09-18
- Data Source
  KAKENHI-PLANNED-22112007
[Presentation] MT1-MMP plays a critical role in the modulation of hematopoiesis2011
- Author(s)
  Chiemi Nishida, Kaori Kusubata, Motoharu Seiki, Hiromitsu Nakauchi, Beate Heissig, Koichi Hattori
- Organizer
  第73回日本血液学会
- Place of Presentation
  名古屋国際会議場、名古屋市
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] The impact of membrane type-1 matrix metalloproteinase and plasminogen deficiency on post-natal hematopoiesis2011
- Author(s)
  Heissig Beate
- Organizer
  3rd Symposium of IMSUT & RCAST Global COE on New Horizon of Stem Cell Biology and Immunotherapy
- Place of Presentation
  東京大学医科学研究所(東京都)
- Year and Date
  2011-03-04
- Data Source
  KAKENHI-PLANNED-22112007
[Presentation] Fibrinolytic factors regulate tumor progression and growth by altering the interaction between cells of the tumor microenvironment2011
- Author(s)
  Beate Heissig
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県)(招待講演)
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] MT1-MMP plays a criticalrole in the cell growth and maturation2011
- Author(s)
  Chiemi Nishida, Kaori Kusubata, Motoharu Seiki, Hiromitsu Nakauchi, Koichi Hattori, Beate Heissig
- Organizer
  ワークショップ「個体レベルのがん研究の魅力:培養細胞と臨床研究をつなぐマトリクス」
- Place of Presentation
  琵琶湖ホテル
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] A role for niches in hematopoietic cell development2011
- Author(s)
  Beate Heissig
- Organizer
  第772回千葉県がんセンター研究局集団会
- Place of Presentation
  千葉県がんセンター(千葉県)(招待講演)
- Year and Date
  2011-10-19
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] Plasmin inhibition reduces lymphoid tumor growth in mice by suppressing matrix metalloproteinase-9 dependent myeloid cell recruitment2011
- Author(s)
  Beate Heissig
- Organizer
  第4回疾患モデルシンポジウム-がん研究のモデル動物-
- Place of Presentation
  癌研究会癌研究所吉田富三記念講堂(東京都)(招待講演)
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] Fibrinolytic factors regulate tumor progression and growth by altering the interaction between cells of the tumor microenvironment2011
- Author(s)
  Beate Heissig
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県)(招待講演)
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PLANNED-22112007
[Presentation] The impact of membrane type-1 matrix metalloproteinase and plasminogen deficiency on post-natal hematopoiesis2011
- Author(s)
  Heissig Beate
- Organizer
  3^<rd> Symposium of IMSUT & RCAST Global COE on New Horizon of Stem Cell Biology and Immunotherapy
- Place of Presentation
  東京大学医科学研究所(東京都)
- Year and Date
  2011-03-04
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] Epidermal growth factor-like domain 7, a vascular niche factor, regulates myelopoiesis2010
- Author(s)
  Ismael Gritli, Chiemi Nishida, Makoto Ishihara, Hiromitsu Nakauchi, Koichi Hattori, Beate Heissig
- Organizer
  The 72nd Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Pacifico Yokohama
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] The fibrinolytic system regulates myeloid cell influx and lymphoma growth2010
- Author(s)
  Heissig Beate
- Organizer
  Global COE Symposium on Current and Future Directions of Dendritic Cell Biology and Immunot herapy
- Place of Presentation
  東京大学医科学研究所(東京都)
- Year and Date
  2010-06-29
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] 癌増殖における線維素溶解系因子の役割と新規治療法の開発2010
- Author(s)
  石原誠人、山本玲、八木田秀雄、奥村康、ハイジッヒベアテ、服部浩一
- Organizer
  第69回日本癌学会学術集会
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] リンパ腫増殖における線維素溶解系の役割と新規治療法の開発2010
- Author(s)
  石原誠人、ハイジッヒベアテ、田代良彦、西田知恵美、小泉摩希子、和中敬子、津田裕子、岡田芳男、八木田秀雄、奥村康、中内啓光、服部浩一
- Organizer
  第72回日本血液学会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] 癌増殖における線維素溶解系因子の役割と新規治療法の開発2010
- Author(s)
  石原誠人、Beate Heissig, ほか
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際コンベンションセンター(大阪府大阪市)
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-ORGANIZER-22112001
[Presentation] 生体内組織再生における線維素溶解系因子PAI-1の機能解明2010
- Author(s)
  田代良彦、Heissig Beate、服部浩一
- Organizer
  第8回血液血管オルビス
- Year and Date
  2010-08-21
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] EGFL7-a novel stress response factor in the bone marrow niche2010
- Author(s)
  Ismael Gritli, Chiemi Nishida, Koichi Hattori, Beate Heissig
- Organizer
  平成22年度医科学研究所研究成果発表会
- Place of Presentation
  東京
- Year and Date
  2010-06-01
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] 生体内組織再生における線維素溶解系因子PAI-1の機能解明2010
- Author(s)
  田代良彦、Heissig Beate、服部浩一
- Organizer
  平成22年度医科学研究所研究成果発表会
- Place of Presentation
  東京
- Year and Date
  2010-06-01
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] MT1-MMP Plays a Critical Role In the Modulation of Hematopoiesis2010
- Author(s)
  Nishida Chiemi, Heissig Beate, Tashiro Yoshihiko, Seiki Motoharu, Hiromithu Nakauchi, Koichi Hattori
- Organizer
  52nd ASH Annual Meeting
- Place of Presentation
  Orange County Convention Center, Orlando, FL
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] 生体内組織再生における線溶系因子PAI-1の機能解明2010
- Author(s)
  田代良彦、石原誠人、西田知恵美、Ismail Gritli1)、小泉摩季子、小見山博光、坂本一博、Beate Heissig、宮田敏男、中内啓光、服部浩一
- Organizer
  第72回日本血液学会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] Plasminogen Deficiency Impairs Erythropoietic Recovery Capacity in Male C57BL/6J Mice through Testosterone Defect2010
- Author(s)
  Okaji Yurai, Nishida Chiemi, Gritli Ismael, Tashiro Yoshihiko, Ohki Makiko, Hattori Koichi, Heissig, Beate
- Organizer
  52nd ASH Annual Meeting
- Place of Presentation
  Orange County Convention Center, Orlando, FL
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] MT1-MMP is a critical modulator of normal hematopoiesis2010
- Author(s)
  Chiemi Nishida, Beate Heissig, Motoharu Seiki, Hiromitsu Nakauchi, Koichi Hattori
- Organizer
  第72回日本血液学会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-21591193
[Presentation] MT1-MMP plays a critical role in chemo-/cytokine expression by regulating HIF activation.
- Author(s)
  Chiemi Nishida, Beate Heissig, Koichi Hattori.
- Organizer
  The 18th International Vascular Biology Meeting (IVBM 2014)
- Place of Presentation
  みやこめっせ（京都府京都市）
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PROJECT-24591382
[Presentation] EGFL7 regulates hematopoietic stem/progenitor cell fate in the bone marrow niche through β3 integrin.
- Author(s)
  Yousef Salama, Chiemi Nishida, Ismael Gritli, Terumasa Umemoto, Hiromitsu Nakauchi, Koichi Hattori, Beate Heissig.
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PLANNED-22112007
[Presentation] Epidermal Growth Factor-like Domain 7 Promotes Hematopoietic Stem Cell Expansion and Increases Myeloid-Megakaryocytic Lineage Priming through beta3 Integrin.
- Author(s)
  Chiemi Nishida, Yousef Salama, Ismael Gritli, Terumasa Umemoto, Hiromitsu Nakauchi, Koichi Hattori, Beate Heissig.
- Organizer
  56th ASH Annual Meeting and Exposition
- Place of Presentation
  San Francisco, California, USA.
- Year and Date
  2014-12-04 – 2014-12-09
- Data Source
  KAKENHI-PLANNED-22112007
[Presentation] The fibrinolytic system modulates the cytokine and cellular environment during cancer progression and chronic inflammation.
- Author(s)
  Beate Heissig
- Organizer
  Joint International Symposium on TGF-β and Cancer
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2015-01-12 – 2015-01-13
- Invited
- Data Source
  KAKENHI-PROJECT-24591382
[Presentation] EGFL7 recruits quiescent HSCs into active cell cycle and expands HSCs.
- Author(s)
  Chiemi Nishida, Yousef Salamam, Koichi Hattori , Beate Heissig.
- Organizer
  The 18th International Vascular Biology Meeting (IVBM 2014)
- Place of Presentation
  みやこめっせ（京都府京都市）
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PROJECT-24591382
[Presentation] Mesenchymal Stem Cells expansion by the fibrinolytic system: implications in the cancer microenvironment.
- Author(s)
  Douaa Dhahri, Kaori Sato-Kusubata, Makiko Ohki-Koizumi, Chiemi Nishida, Hiromitsu Nakauchi, Koichi Hattori and Beate Heissig.
- Organizer
  Gordon Research Conferences "Stem Cells & Cancer"
- Place of Presentation
  Ventura, CA, USA.
- Year and Date
  2015-02-15 – 2015-02-20
- Data Source
  KAKENHI-PROJECT-24591382
[Presentation] The fibrinolytic pathway is required for Mesenchymal Stem Cell expansion by initiating a crosstalk between Mesenchymal Stem and Endothelial cells.
- Author(s)
  Beate Heissig, Douaa Dhahri , Chiemi Nishida , Kaori Kusubata , Makiko Ohki-Koizumi , Koichi Hattori.
- Organizer
  The 18th International Vascular Biology Meeting (IVBM 2014)
- Place of Presentation
  みやこめっせ（京都府京都市）
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PROJECT-24591382
[Presentation] セリンプロテアーゼ阻害薬によるDextran sulfate sodium誘発腸炎の抑制
- Author(s)
  盧尚志,宗像慎也,小見山博光，Heissig Beate,服部浩一,坂本一博
- Organizer
  第115回日本外科学会定期学術集会
- Place of Presentation
  名古屋,名古屋国際会議場
- Year and Date
  2015-04-16 – 2015-04-18
- Data Source
  KAKENHI-PROJECT-25461961
[Presentation] Pharmacological Targeting of Plasmin Prevents Inflammatory Diseases Like Septic Shock and Acute Graft-versus-host Disease
- Author(s)
  Sato A.Heissig B.Hattori K
- Organizer
  XIVth International Workshop Molecular & Cellular Biology of Plasminogen Activation
- Place of Presentation
  University of Notre Dame, Indiana USA
- Data Source
  KAKENHI-PLANNED-22112007
[Presentation] Mesenchymal Stem Cells expansion by the fibrinolytic system: implications in the cancer microenvironment.
- Author(s)
  Douaa Dhahri, Kaori Sato-Kusubata, Makiko Ohki-Koizumi, Chiemi Nishida, Hiromitsu Nakauchi, Koichi Hattori and Beate Heissig.
- Organizer
  Gordon Research Conferences "Stem Cells & Cancer".
- Place of Presentation
  Ventura, CA, USA.
- Year and Date
  2015-02-15 – 2015-02-20
- Data Source
  KAKENHI-PLANNED-22112007
[Presentation] The fibrinolytic pathway is required for Mesenchymal Stem Cell expansion by initiating a crosstalk between Mesenchymal Stem and Endothelial cells.
- Author(s)
  Beate Heissig, Douaa Dhahri , Chiemi Nishida , Kaori Kusubata , Makiko Ohki-Koizumi , Koichi Hattori.
- Organizer
  The 18th International Vascular Biology Meeting (IVBM 2014)
- Place of Presentation
  みやこめっせ（京都府京都市）
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PLANNED-22112007
[Presentation] プラスミン阻害剤による炎症性腸疾患に対する腸管上皮保護と再生促進作
- Author(s)
  宗像慎也、田代良彦、小見山博光、島津浩、佐藤亜紀、西田知恵美、坂本一博、Heissig Beate、服部浩一
- Organizer
  第13回日本再生医療学会
- Place of Presentation
  京都国際会館（京都市）
- Data Source
  KAKENHI-PLANNED-22112007
[Presentation] The fibrinolytic system modulates the cytokine and cellular environment during cancer progression and chronic inflammation.
- Author(s)
  Beate Heissig
- Organizer
  Joint International Symposium on TGF-β and Cancer
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2015-01-12 – 2015-01-13
- Invited
- Data Source
  KAKENHI-PLANNED-22112007
[Presentation] Mesenchymal Stem Cells expansion by the fibrinolytic system: implications in cancer microenvironment.
- Author(s)
  Douaa Dhahri, Kaori Sato-Kusubata, Makiko Ohki-Koizumi, Chiemi Nishida, Koichi Hattori and Beate Heissig.
- Organizer
  Joint International Symposium on TGF-β and Cancer
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2015-01-12 – 2015-01-13
- Data Source
  KAKENHI-PROJECT-24591382
[Presentation] EGFL7 recruits quiescent HSCs into active cell cycle and expands HSCs.
- Author(s)
  Chiemi Nishida, Yousef Salamam, Koichi Hattori , Beate Heissig.
- Organizer
  The 18th International Vascular Biology Meeting (IVBM 2014)
- Place of Presentation
  みやこめっせ（京都府京都市）
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PLANNED-22112007
[Presentation] PAI-1阻害剤による血管新生及び組織再生促進療法
- Author(s)
  宗像慎也,田代良彦,島津浩,西田知恵美,イスマエルグリツリ,佐藤亜紀,小泉摩季子,楠畑かおり,小見山博光,坂本一博,宮田敏男,ハイジッヒベアテ,服部浩一
- Organizer
  第113回日本外科学会定期学術集会
- Place of Presentation
  福岡国際会議場（福岡市）
- Data Source
  KAKENHI-PLANNED-22112007
[Presentation] Mesenchymal Stem Cells expansion by the fibrinolytic system: implications in cancer microenvironment.
- Author(s)
  Douaa Dhahri, Kaori Sato-Kusubata, Makiko Ohki-Koizumi, Chiemi Nishida, Koichi Hattori and Beate Heissig.
- Organizer
  Joint International Symposium on TGF-β and Cancer
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2015-01-12 – 2015-01-13
- Data Source
  KAKENHI-PLANNED-22112007
[Presentation] 腹腔内癒着における線溶系阻害因子PAI-1の機能解明
- Author(s)
  本庄薫平,宗像慎也,小見山博光，Heissig Beate,服部浩一,坂本一博
- Organizer
  第115回日本外科学会定期学術集会
- Place of Presentation
  名古屋,名古屋国際会議場
- Year and Date
  2015-04-16 – 2015-04-18
- Data Source
  KAKENHI-PROJECT-25461961
[Presentation] EGFL7 regulates hematopoietic stem/progenitor cell fate in the bone marrow niche through β3 integrin.
- Author(s)
  Yousef Salama, Chiemi Nishida, Ismael Gritli, Terumasa Umemoto, Hiromitsu Nakauchi, Koichi Hattori, Beate Heissig.
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-24591382
[Presentation] MT1-MMP plays a critical role in chemo-/cytokine expression by regulating HIF activation.
- Author(s)
  Chiemi Nishida, Beate Heissig, Koichi Hattori.
- Organizer
  The 18th International Vascular Biology Meeting (IVBM 2014)
- Place of Presentation
  みやこめっせ（京都府京都市）
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PLANNED-22112007
[Presentation] Epidermal Growth Factor-like Domain 7 Promotes Hematopoietic Stem Cell Expansion and Increases Myeloid-Megakaryocytic Lineage Priming through beta3 Integrin.
- Author(s)
  Chiemi Nishida, Yousef Salama, Ismael Gritli, Terumasa Umemoto, Hiromitsu Nakauchi, Koichi Hattori, Beate Heissig.
- Organizer
  56th ASH Annual Meeting and Exposition
- Place of Presentation
  San Francisco, California, USA.
- Year and Date
  2014-12-04 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-24591382

1. HATTORI Koichi (10360116)

# of Collaborated Projects: 4 results

# of Collaborated Products: 37 results
2. YATSENKO TETIANA

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. MIYAZONO Kohei (90209908)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. AKIYAMA Tetsu (70150745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. FUJITA Naoya (20280951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAKAKURA Nobuyuki (80291954)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SATO Yasufumi (50178779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YANO Seiji (30294672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KONDOH Shinae (40314182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MINAMI Takashi (00345141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TABATA Yasuhiko (50211371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ABURATANI Hiroyuki (10202657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MANO Hiroyuki (90240704)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NAKA Kazuhito (70372688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HARA Eiji (80263268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. Komiyama Hiromitsu (30348982)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
17. ICHIMURA Atsuhiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. TSUDA Yuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 長田太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 高橋聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

Heissig Beate ハイジッヒ ベアーテ

HEISSIG Beate ハイジッヒ ベアーテ

Research Projects

Research Products

Co-Researchers

Role of Slc5a5 in the diagnosis and treatment of drug-resistant cancerPrincipal Investigator

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Elucidation of pathological control mechanism of multiple myeloma by tPA/tPA receptor signalingPrincipal Investigator

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tPA/tPA受容体シグナルによる多発性骨髄腫の病態制御機構の解明Principal Investigator

Principal Investigator

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Role of the angiocrine factor Egfl7 in multiple myeloma progression and drug resistancePrincipal Investigator

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Review Section

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Fibrinolytic factors control MSC expansion thereby enhancing hematopoiesisPrincipal Investigator

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Studies in the action mechanism of fibrinolytic system on the inflammatory bowel disease and its clinical applications

Principal Investigator

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Multifunctional role of Membrane-type 1 matrix metalloproteinase in multiple myelomaPrincipal Investigator

Principal Investigator

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Integrative Research on Cancer Microenvironment Network

Principal Investigator

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Functional analysis of the fibrinolytic system in bone marrow-derived cell mediated tumor angiogenesis and growthPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

The role of plasmin in the regulation of the multiple myeloma microenvironmentPrincipal Investigator

Principal Investigator

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血管内皮細胞由来因子EGFL7のがん血管新生における機能解析Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

新しい血管内皮細胞由来因子EGFL7のがん血管新生における機能解析Principal Investigator

Principal Investigator

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Review Section

Research Institution

脂肪細胞ニッチにおけるADAMsプロテイナーゼの機能的解析Principal Investigator

Principal Investigator

Project Period (FY)

Heissig Beate ハイジッヒベアーテ

HEISSIG Beate ハイジッヒベアーテ

[Book] 実験医学増刊　Vol.33 No.5 （がん微小環境と標的治療）2015

[Book] 実験医学増刊　Vol.33 No.5 （がん微小環境と標的治療）2015