Takamochi Kazuya 高持一矢

… Alternative Names

TAKAMOCHI Kazuya 高持一矢

高持一矢タカモチカズヤ

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Researcher Number	30397369
Other IDs	https://orcid.org/0000-0003-4068-530X
Affiliation (Current)	2025: 順天堂大学, 医学部, 先任准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 順天堂大学, 医学部, 先任准教授 2012 – 2019: 順天堂大学, 医学部, 准教授 2007: Hamamatsu University School of Medicine, 医学部附属病院, 医員 2005 – 2006: 浜松医科大学, 医学部付属病院, 医員
Review Section/Research Field	Principal Investigator Respiratory surgery / Thoracic surgery Except Principal Investigator Basic Section 49020:Human pathology-related / Basic Section 55040:Respiratory surgery-related / Respiratory surgery / Clinical oncology
Keywords	Principal Investigator 肺腺癌 / 免疫学 / MSI / ドライバー遺伝子 / 免疫関連分子 / 肺扁平上皮癌 / 腫瘍免疫 / 非小細胞肺癌 / バイオマーカー / 免疫チェックポイント阻害薬 … More / 免疫治療 / 国内共同研究 / CAGE / 転移性肺腫瘍 / ST6GALNAC1 / SPATS2 / 鑑別マーカー / 扁平上皮癌 / 腺癌 / 肺癌 / mTOR / ゲフィチニブ / FISH / ゲフイチニブ / EGFR / 結節性硬化症遺伝子 … More Except Principal Investigator 肺癌 / 個別化医療 / エンハンサー / トランスクリプトーム解析 / CAGE / 遺伝子 / 肺がん / トランスクリプトーム / がん / 浸潤性 / PET-CT / 早期肺癌 / 多領域シークエンス / バイオマーカー / 免疫療法 / PD-L1 / PD-1 / 多領域シーケンス / 免疫治療 / FANTOM / 転移マーカー / 大腸がん / RNA発現解析 / CAGE解析 / 転移予測マーカー / 次世代シークエンサー / 網羅的発現解析 / 肺転移 / 腫瘍マーカー / 大腸癌 / CAGE法 / 国際情報交換 / 国内多施設共同研究 / 第II相試験 / 術前導入化学放射線療法 / Ｓｕｐｅｒｉｏｒ　Ｓｕｌｃｕｓ　Ｔｕｍｏｒ / 手術 / 術前導入療法 / Superior sulcus tumor Less

Prospective observational study on the diagnosis and validity of invasiveness of early lung cancer based on standardized FDG-PET/CT
- Principal Investigator
  
  渡邊敬夫
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Juntendo University
Development of personalized medicine for lung cancer using next-generation transcriptome
- Principal Investigator
  
  林大久生
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Juntendo University
Elucidation of the molecular mechanism of immunotherapy treatment resistance by microtissue multidisciplinary sequence
- Principal Investigator
  
  Takuo Hayashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Juntendo University
Analysis of Predictive Biomarkers for Immune Checkpoint Inhibitors in Lung AdenocarcinomaPrincipal Investigator
- Principal Investigator
  
  Takamochi Kazuya
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Juntendo University
Identification of biomarker for colorectal cancer metastasis to lung with CAGE analyses
- Principal Investigator
  
  Yaginuma Yukihiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Juntendo University
Novel biomarkers that assist in accurate discrimination of squamous cell carcinoma from adenocarcinoma of the lungPrincipal Investigator
- Principal Investigator
  
  Takamochi Kazuya
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Juntendo University
A phase II study of induction cisplatin plus TS-1 with concurrent radiotherapy (66Gy) followed by surgical resection in patients with superior sulcus tumor
- Principal Investigator
  
  TSUSHIMA Yukio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Clinical oncology
- Research Institution
  Juntendo University
肺腺癌の発癌過程における結節性硬化症遺伝子の関与の解明Principal Investigator
- Principal Investigator
  
  高持一矢
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Hamamatsu University School of Medicine

All 2022 2021 2020 2018 2017 2016 2007 Other

All Journal Article Presentation

[Journal Article] Distinct properties of pure- and mixed-type high-grade fetal lung adenocarcinomas by genetic profiling and transcription factor expression.2022
- Author(s)
  Kishikawa S, Hayashi T, Saito T, Takamochi K, Sasa K, Suehara Y, Takahashi F, Sasahara N, Kohsaka S, Suzuki K, Yao T
- Journal Title
  
  Virchows Arch
  
  Volume: 480 Issue: 3 Pages: 609-619
- DOI
  10.1007/s00428-021-03247-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07469, KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-21K08187
[Journal Article] Transcription start site-level expression of thyroid transcription factor 1 isoforms in lung adenocarcinoma and its clinicopathological significance.2021
- Author(s)
  Sano K, Hayashi T, Suehara Y, Hosoya M, Takamochi K, Kohsaka S, Kishikawa S, Kishi M, Saito S, Takahashi F, Kaneko K, Suzuki K, Yao T, Ishijima M, Saito T.
- Journal Title
  
  J Pathol Clin Res
  
  Volume: 7 Issue: 4 Pages: 361-374
- DOI
  10.1002/cjp2.213
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07469, KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-19K22694, KAKENHI-PROJECT-19H03789
[Journal Article] Histological characteristics of lung adenocarcinoma with uncommon actionable alterations: special emphasis on MET exon 14 skipping alterations2021
- Author(s)
  Hayashi Takuo、Kohsaka Shinji、Takamochi Kazuya、Kishikawa Satsuki、Ikarashi Daiki、Sano Kei、Hara Kieko、Onagi Hiroko、Suehara Yoshiyuki、Takahashi Fumiyuki、Saito Tsuyoshi、Nakatsura Tetsuya、Kitano Shigehisa、Suzuki Kenji、Yao Takashi
- Journal Title
  
  Histopathology
  
  Volume: - Issue: 7 Pages: 1-1
- DOI
  10.1111/his.14311
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22694, KAKENHI-PROJECT-18H02677, KAKENHI-PROJECT-19K07469, KAKENHI-PROJECT-19H03789
[Journal Article] Clinicopathological characteristics of lung adenocarcinoma with compound EGFR mutations.2020
- Author(s)
  Hayashi T, Kohsaka S, Takamochi K, Hara K, Kishikawa S, Sano K, Takahashi F, Suehara Y, Saito T, Takahashi K, Suzuki K, Yao T.
- Journal Title
  
  Human Pathology
  
  Volume: 14 Pages: 42-51
- DOI
  10.1016/j.humpath.2020.07.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08185, KAKENHI-PROJECT-19K22694, KAKENHI-PROJECT-18H02677, KAKENHI-PROJECT-19H03789, KAKENHI-PROJECT-17K09669, KAKENHI-PROJECT-19K07469
[Journal Article] Prognostic impacts of EGFR mutation status and subtype in patients with surgically resected lung adenocarcinoma.2017
- Author(s)
  Takamochi K, Oh S, Matsunaga T, Suzuki K.
- Journal Title
  
  J Thorac Cardiovasc Surg.
  
  Volume: 154 Issue: 5 Pages: 1768-1774
- DOI
  10.1016/j.jtcvs.2017.06.062
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10691
[Journal Article] A method of high-throughput functional evaluation of EGFR gene variants of unknown significance in cancer2017
- Author(s)
  Kohsaka Shinji、Nagano Masaaki、Ueno Toshihide、Suehara Yoshiyuki、Hayashi Takuo、Shimada Naoko、Takahashi Kazuhisa、Suzuki Kenji、Takamochi Kazuya、Takahashi Fumiyuki、Mano Hiroyuki
- Journal Title
  
  Science Translational Medicine
  
  Volume: 9 Issue: 416 Pages: 6566-6566
- DOI
  10.1126/scitranslmed.aan6566
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09230, KAKENHI-PROJECT-16K10691, KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-17K09669, KAKENHI-PROJECT-16K15670, KAKENHI-PROJECT-15KK0353, KAKENHI-PROJECT-15H04964, KAKENHI-PROJECT-26461200
[Journal Article] DNA mismatch repair deficiency in surgically resected lung adenocarcinoma: Microsatellite instability analysis using the Promega panel2017
- Author(s)
  Takamochi Kazuya、Takahashi Fumiyuki、Suehara Yoshiyuki、Sato Eiichi、Kohsaka Shinji、Hayashi Takuo、Kitano Shigehisa、Uneno Toshihide、Kojima Shinya、Takeuchi Kengo、Mano Hiroyuki、Suzuki Kenji
- Journal Title
  
  Lung cancer
  
  Volume: 110 Pages: 26-31
- DOI
  10.1016/j.lungcan.2017.05.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09230, KAKENHI-PROJECT-16K10691, KAKENHI-PROJECT-17K09669, KAKENHI-PROJECT-16K15670, KAKENHI-PROJECT-15KK0353, KAKENHI-PROJECT-15H04964, KAKENHI-PROJECT-26461200
[Journal Article] Novel biomarkers that assist in accurate discrimination of squamous cell carcinoma from adenocarcinoma of the lung2016
- Author(s)
  Takamochi, Kazuya;Ohmiya, Hiroko;Itoh, Masayoshi;Mogushi, Kaoru;Saito, Tsuyoshi;Hara, Kieko;Mitani, Keiko;Kogo, Yasushi;Yamanaka, Yasunari;Kawai, Jun;Hayashizaki, Yoshihide;Oh, Shiaki;Suzuki, Kenji;Kawaji, Hideya
- Journal Title
  
  BMC CANCER
  
  Volume: 16 Issue: 1 Pages: 760-760
- DOI
  10.1186/s12885-016-2792-1
- Data Source
  KAKENHI-PROJECT-16K10691
[Journal Article] Novel biomarkers that assist in accurate discrimination of squamous cell carcinoma from adenocarcinoma of the lung2016
- Author(s)
  Takamochi K, Ohmiya H, Itoh　M, Mogushi K, SaitoT, Hara　K, Mitani　K, Kogo Y, Yamanaka Y, Kawai J, Hayashizaki　Y, Oh　S, Suzuki　K, Kawaji　H
- Journal Title
  
  BMC cancer
  
  Volume: 16:760 Pages: 1-10
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462136
[Journal Article] Readministration of gefitinib in a responder after treatment discontinuation due to gefitinib-related interstitial lung disease:a case report2007
- Author(s)
  Takamochi K, et. al.
- Journal Title
  
  J Med Case Reports 1
  
  Pages: 138-138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17790944
[Journal Article] PIK3CA mutation and amplification in human lung cancer.2007
- Author(s)
  Okudela K, Takamochi K, et. al.
- Journal Title
  
  Pathol Int. 58
  
  Pages: 664-71
- NAID
  10021233920
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17790944
[Journal Article] Surgical resection after gefitinib treatment in patients with lung adenocarcinoma harboring epideimal growth factor receptor gene mutatiion2007
- Author(s)
  Takamochi K, et. al.
- Journal Title
  
  Lung Cancer 58
  
  Pages: 149-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17790944
[Journal Article] Surgical Resection after Gefitinib Treatment in Patients with Lung Adenocarcinoma Harboring Epidermal Growth Factor Receptor Gene Mutation
- Author(s)
  K.Takamochi
- Journal Title
  
  Lung Cancer (In press)
- Data Source
  KAKENHI-PROJECT-17790944
[Presentation] Comprehensive analysis for immune profiles of tumor microenvironment in lung adenocarcinomas: Prognostic effect of immunomodulatory molecules.2018
- Author(s)
  Kazuya Takamochi, Masaki Hosoya, Kaoru Mogushi, Takuo Hayashi, Masayoshi Ito, Hideya Kawaji, Yoshihide Hayashizaki, Kenji Suzuki
- Organizer
  ESMO MAP
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10691
[Presentation] Comprehensive analysis for immune profiles of tumor microenvironment in non-small cell lung cancers: Prognostic effect of immunomodulatory molecules.2018
- Author(s)
  Kazuya Takamochi, Masaki Hosoya, Kaoru Mogushi, Takuo Hayashi, Masayoshi Ito, Hideya Kawaji, Yoshihide Hayashizaki, Kenji Suzuki
- Organizer
  ESMO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10691
[Presentation] 肺腺癌における免疫関連分子の包括的遺伝子発現解析.2018
- Author(s)
  高持一矢、細谷理樹、茂櫛　薫、林　大久生、川路英哉、伊藤昌可、林崎良英、鈴木健司
- Organizer
  日本肺癌学会
- Data Source
  KAKENHI-PROJECT-16K10691
[Presentation] The PD-L1 expression in surgically resected lung adenocarcinoma: Its correlations with the prognosis, driver oncogene alterations and clinicopathological features.2018
- Author(s)
  Kazuya Takamochi, Takuo Hayashi, Kieko Hara, Kenji Suzuki
- Organizer
  ESMO Asia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10691
[Presentation] Practical screening system of oncogenic driver fusions in lung adenocarcinoma, using the NanoString nCounter2017
- Author(s)
  Kazuya Takamochi, Yoshiyuki Suehara, Fumiyuki Takahashi, Kaoru Mogushi, Shinji Kohsaka, Hiroyuki Mano, Kengo Takeuchi, Tsuyoshi Saito, Takuo Hayashi, Kazuhisa Takahashi, Kenji Suzuki
- Organizer
  ESMO MAP
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10691
[Presentation] NanoString nCounterを用いた肺腺癌におけるドライバー融合遺伝子の効率的スクリーニングシステムの開発2017
- Author(s)
  高持一矢、王　志明、松永健志、鈴木健司
- Organizer
  第70回日本胸部外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-16K10691
[Presentation] A microsatellite instability analysis using the Promega panel in lung adenocarcinoma2016
- Author(s)
  Kazuya Takamochi, Fumiyuki Takahashi, Yoshiyuki Suehara, Shigehisa Kitano, Eiichi Sato, Shinji Kohsaka, Kenji Suzuki "
- Organizer
  CHEST
- Place of Presentation
  Los Angeles, Los Angeles Convention Center
- Year and Date
  2016-10-22
- Data Source
  KAKENHI-PROJECT-16K10691
[Presentation] 肺腺癌切除例におけるEGFR遺伝子変異の有無、EGFR遺伝子変異タイプの予後因子としての意義2016
- Author(s)
  高持一矢、王　志明、松永健志、鈴木健司
- Organizer
  第57回日本肺癌学会学術集会
- Place of Presentation
  福岡, 福岡国際会議場, 福岡サンパレス
- Year and Date
  2016-12-19
- Data Source
  KAKENHI-PROJECT-16K10691
[Presentation] The prognostic impact of EGFR mutation status and mutation subtypes in patients with surgically resected lung adenocarcinomas2016
- Author(s)
  Kazuya Takamochi, Shiaki Oh, Takeshi Matsunaga, Kenji Suzuki
- Organizer
  17th WCLC
- Place of Presentation
  Vienna, Messe Wien Exhibition & Congress Center
- Year and Date
  2016-12-04
- Data Source
  KAKENHI-PROJECT-16K10691
[Presentation] A microsatellite instability analysis using the Promega panel in lung adenocarcinoma2016
- Author(s)
  Kazuya Takamochi, Fumiyuki Takahashi, Yoshiyuki Suehara, Shigehisa Kitano, Eiichi Sato, Shinji Kohsaka, Kenji Suzuki
- Organizer
  第14回日本臨床腫瘍学会学術集会
- Place of Presentation
  神戸, 神戸国際会議場
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-16K10691
[Presentation] The role of gene mutations and amplifications involved in epidermal growth factor receptor pathways in non-small cell lung cancer2007
- Author(s)
  Takamochi K, et. al.
- Organizer
  The world conference on lung cancer
- Place of Presentation
  Seoul(Korea)
- Year and Date
  2007-09-04
- Data Source
  KAKENHI-PROJECT-17790944

1. SUZUKI Kenji (10415523)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. OH Shiaki (50306958)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. KAWAI Jun (30391923)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. Takuo Hayashi (70569128)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. TSUSHIMA Yukio (20560684)

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6. OKADA Morihito (70446045)

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7. IKEDA Norihiko (70246205)

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8. TANAKA Fumihiro (10283673)

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9. OKUMURA Sakae (40465935)

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10. NAKAMURA Haruhiko (80183523)

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11. SUZUKI Hiroyuki (30322340)

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12. NAKAMURA Hiroshige (30252852)

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13. IWATA Hisashi (90303495)

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14. TSUBOI Masahiro (90297309)

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15. SUGIO Kenji (70235927)

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16. MANIWA Yoshimasa (50362778)

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17. UEDA Kazuhiro (90420520)

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18. DOKI Yoshinori (90303221)

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19. MAEHARA Yoshihiko (80165662)

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20. UENO Tsuyoshi (80509456)

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21. TAKENOYAMA Mitsuhiro (10309966)

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22. URAMOTO Hidetaka (90389445)

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23. YOSHINO Ichiro (40281547)

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24. KOGO Yasushi (20462682)

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25. Yaginuma Yukihiro (60338415)

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26. 小見山博光 (30348982)

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27. 藤井智明 (10511420)

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28. 細川正人 (60722981)

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29. 末原義之 (70509405)

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30. 齋藤剛 (80439736)

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31. 渡邊敬夫 (80834449)

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32. 伊藤公輝 (40602074)

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33. 村上康二 (50200267)

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34. 大崎洋充 (90392349)

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35. 村川泰裕 (50765469)

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36. 高阪真路 (00627119)

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37. 北野滋久 (60402682)

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38. 松永浩子 (10592024)

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39. NAGASIMA Takuya

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40. SHIONO Satoshi

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41. MATSUURA Motoki

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42. OKUMURA Norihito

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43. HORIO Hirotoshi

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44. INASAWA Keitaro

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45. FUNAI Kazuhito

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46. ITOU Hiroyuki

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47. 高橋和久

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48. 高橋史行

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Takamochi Kazuya 高持 一矢

TAKAMOCHI Kazuya 高持 一矢

高持 一矢 タカモチ カズヤ

Research Projects

Research Products

Co-Researchers

Prospective observational study on the diagnosis and validity of invasiveness of early lung cancer based on standardized FDG-PET/CT

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of personalized medicine for lung cancer using next-generation transcriptome

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the molecular mechanism of immunotherapy treatment resistance by microtissue multidisciplinary sequence

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of Predictive Biomarkers for Immune Checkpoint Inhibitors in Lung AdenocarcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of biomarker for colorectal cancer metastasis to lung with CAGE analyses

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel biomarkers that assist in accurate discrimination of squamous cell carcinoma from adenocarcinoma of the lungPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A phase II study of induction cisplatin plus TS-1 with concurrent radiotherapy (66Gy) followed by surgical resection in patients with superior sulcus tumor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肺腺癌の発癌過程における結節性硬化症遺伝子の関与の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Distinct properties of pure- and mixed-type high-grade fetal lung adenocarcinomas by genetic profiling and transcription factor expression.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcription start site-level expression of thyroid transcription factor 1 isoforms in lung adenocarcinoma and its clinicopathological significance.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Histological characteristics of lung adenocarcinoma with uncommon actionable alterations: special emphasis on MET exon 14 skipping alterations2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinicopathological characteristics of lung adenocarcinoma with compound EGFR mutations.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognostic impacts of EGFR mutation status and subtype in patients with surgically resected lung adenocarcinoma.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A method of high-throughput functional evaluation of EGFR gene variants of unknown significance in cancer2017

Takamochi Kazuya 高持一矢

TAKAMOCHI Kazuya 高持一矢

高持一矢タカモチカズヤ