Fumihiko Hayakawa 早川文彦

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FUMIHIKO Hayakawa 早川文彦

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Researcher Number	30402580
Other IDs
Affiliation (Current)	2025: 名古屋大学, 医学系研究科(保健), 教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 名古屋大学, 医学系研究科(保健), 教授 2014 – 2017: 名古屋大学, 医学部附属病院, 講師 2010 – 2014: Nagoya University, 医学部附属病院, 助教 2008 – 2009: Nagoya University, 大学院・医学系研究科, COE特任講師 2007: Nagoya University, 医学部・附属病院, 医員 2006: 名古屋大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Hematology / Basic Section 54010:Hematology and medical oncology-related / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Biological Sciences Except Principal Investigator Hematology
Keywords	Principal Investigator 白血病 / 急性リンパ性白血病 / 分子生物学 / 融合遺伝子 / MEF2D / 薬剤スクリーニング / PAX5 / 蛋白翻訳後修飾 / SUMO化 / アセチル化 … More / 癌 / RNA-seq / GSEA / ZNF384融合遺伝子 / CEBP-IGH / 転写標的探索 / 転写因子 / ヒストン脱アセチル化酵素 / スプライシング誘導 / スプライシング / 分化誘導療法 / 遺伝子解析 / micro RNA / ID2 / SALL4 / 発がんメカニズム / カスペース / スタウロスポリン / マイクロRNA / ZNF384 / reactive oxygen species / 酸化ストレス / 微小環境 / Ph陽性ALL / スクリーニング / 悪性リンパ腫 / ドラッグリポジショニング / PDXスクリーニング / PDX / B細胞受容体シグナル / 形質細胞分化 / タンパク翻訳後修飾 / シグナル伝達 / 免疫学 / リンパ球分化 / 抗がん剤 / 白血病モデルマウス / 抗癌剤 / STAT3 / ヒト化マウス / 分子標的薬 / STAT阻害剤 / 抗体アレイ / 発ガン機構 / 発癌機構 / 融合癌遺伝子 / PML / 蛋白SUMO化 / 蛋白アセチル化 / 翻訳後修飾 / ヒストン脱アセチル化酵素阻害剤 … More Except Principal Investigator シグナル伝達 / トランスレーショナルリサーチ / 癌 / 標準治療 / 酸化ストレス / PDX / 悪性リンパ腫 / 微小環境 / 薬剤スクリーニング / 中鎖脂肪酸誘導体 / pyruvinium pamoate / STAT3/5阻害剤 / 分子標的剤 / FLT3阻害剤 Less

日本人に特徴的な白血病原性融合遺伝子の白血病発症機構の解明Principal Investigator
- Principal Investigator
  
  早川文彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Nagoya University
Development of a new treatment of leukemia with the induction of the differentiation-initiating isoform of MEF2D by splicing manipulationPrincipal Investigator
- Principal Investigator
  
  HAYAKAWA FUMIHIKO
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Nagoya University
Investigation of molecular mechanism of new recurrent fusion genes in ALLPrincipal Investigator
- Principal Investigator
  
  Hayakawa Fumihiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Nagoya University
Screening of therapeutic agent for Ph-positive ALL using patient-derived xenograft cellsPrincipal Investigator
- Principal Investigator
  
  Fumihiko Hayakawa
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nagoya University
形質細胞分化運命決定におけるMAPKシグナルの役割とその破綻によるリンパ腫発症Principal Investigator
- Principal Investigator
  
  早川文彦
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Translational research toward drug discovery of leukemia
- Principal Investigator
  
  NAOE Tomoki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  National Hospital Organization Nagoya Medical Center
Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cells
- Principal Investigator
  
  NAOE TOMOKI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  National Hospital Organization Nagoya Medical Center
Mechanism of action of a novel STAT3 inhibitor and its effect on leukemic stem cellPrincipal Investigator
- Principal Investigator
  
  HAYAKAWA Fumihiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nagoya University
Elucidation of the mechanism of PML NB foromation.Principal Investigator
- Principal Investigator
  
  FUMIHIKO Hayakawa
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nagoya University
白血病関連遺伝子産物のPMLアセチル化の意義Principal Investigator
- Principal Investigator
  
  早川文彦
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Nagoya University

[Book] 血液疾患最新の治療　2017-20192017
- Author(s)
  早川文彦　他
- Total Pages
  370
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-15K09472
[Book] 急性リンパ性白血病（ALL）の基礎と臨床2016
- Author(s)
  早川文彦　他
- Total Pages
  286
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-15K09472
[Book] 専門医のための薬物療法Q&A2011
- Author(s)
  早川文彦　他
- Total Pages
  394
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-23591381
[Journal Article] Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemia2023
- Author(s)
  Noura Mina、Matsuo Hidemasa、Yasuda Takahiko、Tsuzuki Shinobu、Kiyoi Hitoshi、Hayakawa Fumihiko
- Journal Title
  
  Oncogene
  
  Volume: 43 Issue: 6 Pages: 447-456
- DOI
  10.1038/s41388-023-02913-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K15298, KAKENHI-PROJECT-22K08475, KAKENHI-PROJECT-21K08384, KAKENHI-PROJECT-21K19505, KAKENHI-PROJECT-23K27624
[Journal Article] EBF1-JAK2 inhibits the PAX5 function through physical interaction with PAX5 and kinase activity.2023
- Author(s)
  Kojima Y, Kawashima F, Yasuda T, et al.
- Journal Title
  
  Int J Hematol.
  
  Volume: in press Issue: 1 Pages: 65-74
- DOI
  10.1007/s12185-023-03585-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24362, KAKENHI-PROJECT-23K15298, KAKENHI-PROJECT-22K08490, KAKENHI-PROJECT-21K08384, KAKENHI-PROJECT-21K19505, KAKENHI-PROJECT-23K27624
[Journal Article] 抗体医薬を用いたB-ALL治療の進歩2023
- Author(s)
  早川文彦
- Journal Title
  
  血液内科
  
  Volume: 87 Pages: 29-33
- Data Source
  KAKENHI-PROJECT-21K19505
[Journal Article] 造血器腫瘍の現在と未来　AYA世代急性リンパ性白血病2023
- Author(s)
  早川文彦
- Journal Title
  
  小児科診療
  
  Volume: 86 Pages: 902-905
- Data Source
  KAKENHI-PROJECT-21K19505
[Journal Article] Oncogenic lesions and molecular subtypes in adults with B‐cell acute lymphoblastic leukemia2022
- Author(s)
  Yasuda Takahiko、Sanada Masashi、Tsuzuki Shinobu、Hayakawa Fumihiko
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 1 Pages: 8-15
- DOI
  10.1111/cas.15583
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08384, KAKENHI-PROJECT-21K19505, KAKENHI-PROJECT-20H00528, KAKENHI-PROJECT-20K08723, KAKENHI-PROJECT-23K24362
[Journal Article] Periosteum-derived podoplanin-expressing stromal cells regulate nascent vascularization during epiphyseal marrow development2022
- Author(s)
  Tamura Shogo、Mukaide Masato、Katsuragi Yumi、Fujii Wataru、Odaira Koya、Suzuki Nobuaki、Tsukiji Nagaharu、Okamoto Shuichi、Suzuki Atsuo、Kanematsu Takeshi、Katsumi Akira、Takagi Akira、Ikeda Katsuhide、Ueyama Jun、Hirayama Masaaki、Suzuki-Inoue Katsue、Matsushita Tadashi、Kojima Tetsuhito、Hayakawa Fumihiko
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 5 Pages: 101833-101833
- DOI
  10.1016/j.jbc.2022.101833
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19505, KAKENHI-PROJECT-22K06881, KAKENHI-PROJECT-22K08500, KAKENHI-PROJECT-22K08518, KAKENHI-PROJECT-19K08853, KAKENHI-PROJECT-20K08711
[Journal Article] F9 mRNA splicing aberration due to a deep Intronic structural variation in a patient with moderate hemophilia B2022
- Author(s)
  Odaira Koya、Kawashima Fumika、Tamura Shogo、Suzuki Nobuaki、Tokoro Mahiru、Hayakawa Yuri、Suzuki Atsuo、Kanematsu Takeshi、Okamoto Shuichi、Takagi Akira、Katsumi Akira、Matsushita Tadashi、Shima Midori、Nogami Keiji、Kojima Tetsuhito、Hayakawa Fumihiko
- Journal Title
  
  Thrombosis Research
  
  Volume: 213 Pages: 91-96
- DOI
  10.1016/j.thromres.2022.03.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19505, KAKENHI-PROJECT-22K08518, KAKENHI-PROJECT-19K08853, KAKENHI-PROJECT-20K08711
[Journal Article] Essential role of a carboxyl-terminal α-helix motif in the secretion of coagulation factor XI.2021
- Author(s)
  Hayakawa Y, Tamura S, Suzuki N, Odaira K, Tokoro M, Kawashima F, Hayakawa F, Takagi A, Katsumi A, Suzuki A, Okamoto S, Kanematsu T, Matsushita T, Kojima T.
- Journal Title
  
  J Thromb Haemost.
  
  Volume: - Issue: 4 Pages: 920-930
- DOI
  10.1111/jth.15242
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08711, KAKENHI-PROJECT-18H02835, KAKENHI-PROJECT-17H05073, KAKENHI-PROJECT-19K08853
[Journal Article] Combination of clofarabine, etoposide, and cyclophosphamide in adult relapsed/refractory acute lymphoblastic leukemia: a phase 1/2 dose-escalation study by the Japan Adult Leukemia Study Group.2021
- Author(s)
  Saito T, Hatta Y, Hayakawa F, Takahashi T, Hagihara M, Iida H, Minauchi K, Yamazaki E, Sugiura I, Murayama T, Sakura T, Mori N, Imai K, Yahagi Y, Atsuta Y, Saito AM, Hirakawa A, Kiyoi H, Matsumura I, Miyazaki Y
- Journal Title
  
  Int J Hematol.
  
  Volume: 113 Issue: 3 Pages: 395-403
- DOI
  10.1007/s12185-020-03032-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02835, KAKENHI-PROJECT-18K08375
[Journal Article] Staurosporine and venetoclax induce the caspase- dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells.2020
- Author(s)
  Tange N, Hayakawa F, Yasuda T, Odaira K, Yamamoto H, Hirano D, Sakai T, Terakura S, Tsuzuki S, Kiyoi H.
- Journal Title
  
  Biomed Pharmacother.
  
  Volume: 128 Pages: 110330-110330
- DOI
  10.1016/j.biopha.2020.110330
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02835, KAKENHI-PROJECT-18K08351, KAKENHI-PROJECT-16H06276
[Journal Article] Higher FVIII:C Measured by Chromogenic Substrate Assay Than by One-Stage Assay Is Associated With Silent Hemophilic Arthropathy2020
- Author(s)
  Mika Ogawa, Nobuaki Suzuki, Nobunori Takahashi, Shogo Tamura, Atsuo Suzuki, Sachiko Suzuki, Yuua Hattori, Misaki Kakihara, Takeshi Kanematsu, Toshihisa Kojima, Akira Katsumi, Fumihiko Hayakawa, Tetsuhito Kojima, Naoki Ishiguro , Hitoshi Kiyoi , Tadashi Matsushita
- Journal Title
  
  Thromb Res
  
  Volume: 188 Pages: 103-105
- DOI
  10.1016/j.thromres.2020.01.003
- NAID
  120006872431
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08853, KAKENHI-PROJECT-17H05073, KAKENHI-PROJECT-17K09902, KAKENHI-PROJECT-17K09921, KAKENHI-PROJECT-18K19910, KAKENHI-PROJECT-20K08711, KAKENHI-PROJECT-18H02835
[Journal Article] A case of pemphigus with anti-desmoglein 3 and anti-desmocollin 2 and 3 autoantibodies, associated with follicular lymphoma and bronchiolitis obliterans.2020
- Author(s)
  Yoshikawa M, Takeichi T, Taki T, Hayakawa F, Ishii N, Hashimoto T, Muro Y, Akiyama M.
- Journal Title
  
  Eur J Dermatol.
  
  Volume: 30 Issue: 4 Pages: 424-425
- DOI
  10.1684/ejd.2020.3812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02835, KAKENHI-PROJECT-18K08275
[Journal Article] High prevalence of MEF2D fusion in human B-cell precursor acute lymphoblastic leukemia cell lines.2020
- Author(s)
  Akahane K, Yasuda T, Tsuzuki S, Hayakawa F, Kiyokawa N, Somazu S, Watanabe A, Kagami K, Abe M, Harama D, Goi K, Kawazu M, Kojima S, Imamura T, Goto H, Iwamoto S, Minegishi M, Abe M, Hojo H, Inaba T, Mano H, Sugita K, Inukai T.
- Journal Title
  
  Hematol Oncol.
  
  Volume: 38 Issue: 4 Pages: 614-617
- DOI
  10.1002/hon.2762
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02835, KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-19H03615
[Journal Article] 【急性白血病-最新の診断と治療-】急性白血病の分子病態　AYA世代急性白血病の分子病態.2020
- Author(s)
  早川文彦
- Journal Title
  
  日本臨床
  
  Volume: 78 Pages: 418-423
- Data Source
  KAKENHI-PROJECT-18H02835
[Journal Article] Targeting MEF2D-fusion oncogenic transcriptional circuitries in B-cell precursor acute lymphoblastic leukemia2020
- Author(s)
  Tsuzuki S, Yasuda T, Kojima S, Kawazu M, Akahane K, Inukai T, Imaizumi M, Morishita T, Miyamura K, Ueno T, Karnan S, Ota A, Hyodo T, Konishi H, Sanada M, Nagai H, Horibe K, Tomita A, Suzuki K, Muramatsu H, Takahashi Y, Miyazaki Y, Matsumura I, Kiyoi H, Hosokawa Y, Mano H, Hayakawa F.
- Journal Title
  
  Blood Cancer Discovery.
  
  Volume: 1 Pages: 82-95
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02835
[Journal Article] 最近の血栓止血異常のとらえかた　検査室や研究室から　先天性凝固異常症の遺伝子解析　解析のStrategyとPitfall.2020
- Author(s)
  田村彰吾, 高木明, 早川文彦, 小嶋哲人
- Journal Title
  
  日本検査血液学会雑誌
  
  Volume: 21 Pages: 71-78
- Data Source
  KAKENHI-PROJECT-18H02835
[Journal Article] Aberrant X chromosomal rearrangement through multi‐step template switching during sister chromatid formation in a patient with severe hemophilia A2020
- Author(s)
  Tokoro Mahiru、Tamura Shogo、Suzuki Nobuaki、Kakihara Misaki、Hattori Yuna、Odaira Koya、Suzuki Sachiko、Takagi Akira、Katsumi Akira、Hayakawa Fumihiko、Okamoto Shuichi、Suzuki Atsuo、Kanematsu Takeshi、Matsushita Tadashi、Kojima Tetsuhito
- Journal Title
  
  Molecular Genetics & Genomic Medicine
  
  Volume: 8 Issue: 9 Pages: 1-12
- DOI
  10.1002/mgg3.1390
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08853, KAKENHI-PROJECT-20K08711, KAKENHI-PROJECT-18H02835, KAKENHI-PROJECT-17H05073
[Journal Article] Vaticanol C, a phytoalexin, induces apoptosis of leukemia and cancer cells by modulating expression of multiple sphingolipid metabolic enzymes2020
- Author(s)
  Inoue C, Sobue S, Mizutani N, Kawamoto Y, Nishizawa Y, Ichihara M, Takeuchi T, Hayakawa F, Suzuki M, Ito T, Nozawa Y, Murate T.
- Journal Title
  
  Nagoya Journal of Medical Science
  
  Volume: 82 Issue: 2 Pages: 261-280
- DOI
  10.18999/nagjms.82.2.261
- NAID
  120006847437
- ISSN
  2186-3326
- URL
  https://nagoya.repo.nii.ac.jp/records/30090
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02835
[Journal Article] Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells2020
- Author(s)
  Inoue Chisato、Sobue Sayaka、Kawamoto Yoshiyuki、Nishizawa Yuji、Ichihara Masatoshi、Abe Akihiro、Hayakawa Fumihiko、Suzuki Motoshi、Nozawa Yoshinori、Murate Takahsi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 525 Issue: 4 Pages: 1074-1080
- DOI
  10.1016/j.bbrc.2020.02.165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02698, KAKENHI-PROJECT-18H02835, KAKENHI-PROJECT-16K09860
[Journal Article] Functional analysis of a novel fusion protein PAX5-KIDINS220 identified in a pediatric Ph-like ALL patient.2020
- Author(s)
  Kanayama T, Imamura T, Mayumi A, Soma E, Sakamoto K, Hayakawa F, Tanizawa A, Kiyokawa N, Hosoi H.
- Journal Title
  
  Int J Hematol.
  
  Volume: 112 Issue: 5 Pages: 714-719
- DOI
  10.1007/s12185-020-02944-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02835
[Journal Article] JSH practical guidelines for hematological malignancies, 2018: I. leukemia-3. acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL).2020
- Author(s)
  Hatta Y, Hayakawa F, Yamazaki E.
- Journal Title
  
  Int J Hematol.
  
  Volume: 112 Issue: 4 Pages: 439-458
- DOI
  10.1007/s12185-020-02965-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02835
[Journal Article] Chromosomal translocation-mediated evasion from miRNA induces strong MEF2D fusion protein expression, causing inhibition of PAX5 transcriptional activity.2019
- Author(s)
  Hirano D, Hayakawa F, Yasuda T, Tange N, Yamamoto H, Kojima Y, Morishita T, Imoto N, Tsuzuki S, Mano H, Naoe T, Kiyoi H.
- Journal Title
  
  Oncogene
  
  Volume: 38 Issue: 13 Pages: 2263-2274
- DOI
  10.1038/s41388-018-0573-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09921, KAKENHI-PROJECT-18K16103, KAKENHI-PROJECT-18H02645, KAKENHI-PROJECT-18H02835
[Journal Article] Apparent Synonymous Mutation F9 c.87A>G Causes Secretion Failure by In-Frame Mutation With Aberrant Splicing2019
- Author(s)
  Odaira K, Tamura S, Suzuki N, Kakihara M, Hattori Y, Tokoro M, Suzuki S, Takagi A, Katsumi A, Hayakawa F, Okamoto S, Suzuki A, Kanematsu T, Matsushita T, Kojima T.
- Journal Title
  
  Thromb Res
  
  Volume: 179 Pages: 95-103
- DOI
  10.1016/j.thromres.2019.04.022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08853, KAKENHI-PROJECT-18H02835, KAKENHI-PROJECT-17H05073, KAKENHI-PROJECT-17K09902, KAKENHI-PROJECT-18K19910
[Journal Article] ZNF384-fusion proteins have high affinity for the transcriptional coactivator EP300 and aberrant transcriptional activities.2019
- Author(s)
  3.Yamamoto H, Hayakawa F, Yasuda T, Odaira K, Minamikawa Y, Tange N, Hirano D,Kojima Y, Morishita T, Tsuzuki S, Naoe T, Kiyoi H.
- Journal Title
  
  FEBS Lett.
  
  Volume: 593 Issue: 16 Pages: 2151-2161
- DOI
  10.1002/1873-3468.13506
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02835, KAKENHI-PROJECT-17K09921, KAKENHI-PROJECT-18K16103
[Journal Article] Molecular basis of SERPINC1 mutations in Japanese patients with antithrombin deficiency2019
- Author(s)
  Tamura Shogo、Hashimoto Erika、Suzuki Nobuaki、Kakihara Misaki、Odaira Koya、Hattori Yuna、Tokoro Mahiru、Suzuki Sachiko、Takagi Akira、Katsumi Akira、Hayakawa Fumihiko、Suzuki Atsuo、Okamoto Shuichi、Kanematsu Takeshi、Matsushita Tadashi、Kojima Tetsuhito
- Journal Title
  
  Thrombosis Research
  
  Volume: 178 Pages: 159-170
- DOI
  10.1016/j.thromres.2019.04.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09451, KAKENHI-PROJECT-19K08853, KAKENHI-PROJECT-18H02835, KAKENHI-PROJECT-17H05073, KAKENHI-PROJECT-17K09902, KAKENHI-PROJECT-18K19910
[Journal Article] Pyruvate secreted from patient-derived cancer-associated fibroblasts supports survival of primary lymphoma cells.2019
- Author(s)
  Sakamoto A, Kunou S, Shimada K, Tsunoda M, Aoki T, Iriyama C, Tomita A, Nakamura S, Hayakawa F, Kiyoi H.
- Journal Title
  
  Cancer Sci
  
  Volume: 110 Issue: 1 Pages: 269-278
- DOI
  10.1111/cas.13873
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09921, KAKENHI-PROJECT-17K09922, KAKENHI-PROJECT-18H02835
[Journal Article] Adult acute lymphoblastic leukemia: update on pathophysiology and management2018
- Author(s)
  Hayakawa F.
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 59 Issue: 5 Pages: 497-503
- DOI
  10.11406/rinketsu.59.497
- NAID
  130007384462
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02835
[Journal Article] Transcriptional activities of DUX4 fusions in B-cell acute lymphoblastic leukemia2018
- Author(s)
  Tanaka Yosuke、Kawazu Masahito、Yasuda Takahiko、Tamura Miki、Hayakawa Fumihiko、Kojima Shinya、Ueno Toshihide、Kiyoi Hitoshi、Naoe Tomoki、Mano Hiroyuki
- Journal Title
  
  Haematologica
  
  Volume: 103 Issue: 11 Pages: 522-526
- DOI
  10.3324/haematol.2017.183152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-17K09921, KAKENHI-PROJECT-18K16103, KAKENHI-PROJECT-18H02835, KAKENHI-PROJECT-17J10130
[Journal Article] Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases.2018
- Author(s)
  Li JF, Dai YT, Kubota Y, Kiyoi H, Matsumura I, Miyazaki Y, Olsson L, Tan AM, Ariffin H, Chen J, Takita J, Yasuda T, Mano H, Johansson B, Yang JJ, Yeoh AE, Hayakawa F, Chen Z, Pui CH, Fioretos T, Chen SJ, Huang JY.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 115 Issue: 50
- DOI
  10.1073/pnas.1814397115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09921, KAKENHI-PROJECT-18K19467, KAKENHI-PROJECT-18K16103, KAKENHI-PROJECT-17H04209, KAKENHI-PROJECT-17H04224, KAKENHI-PROJECT-18H02835
[Journal Article] Final analysis of the JALSG Ph+ALL202 study: tyrosine kinase inhibitor-combined chemotherapy for Ph+ALL2018
- Author(s)
  Hatta Y, Mizuta S, Matsuo K, Ohtake S, Iwanaga M, Sugiura I, Doki N, Kanamori H, Ueda Y, Yoshida C, Dobashi N, Maeda T, Yujiri T, Monma F, Ito Y, Hayakawa F, Takeuchi J, Kiyoi H, Miyazaki Y, Naoe T
- Journal Title
  
  Ann Hematol
  
  Volume: 97 Issue: 9 Pages: 1535-1545
- DOI
  10.1007/s00277-018-3323-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09921, KAKENHI-PROJECT-18K08358, KAKENHI-PROJECT-17H04209, KAKENHI-PROJECT-18H02835
[Journal Article] Biology and management of primary effusion lymphoma.2018
- Author(s)
  Shimada K, Hayakawa F, Kiyoi H
- Journal Title
  
  Blood
  
  Volume: 132 Issue: 18 Pages: 1879-1888
- DOI
  10.1182/blood-2018-03-791426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09921, KAKENHI-PROJECT-17K09922, KAKENHI-PROJECT-18H02835
[Journal Article] BCL2 inhibitor ABT-199 and JNK inhibitor SP600125 exhibit synergistic cytotoxicity against imatinib-resistant Ph+ ALL cells.2018
- Author(s)
  Inoue C, Sobue S, Aoyama Y, Mizutani N, Kawamoto Y, Nishizawa Y, Ichihara M, Abe A, Hayakawa F, Suzuki M, Nozawa Y, Murate T.
- Journal Title
  
  Biochem Biophys Rep.
  
  Volume: 15 Pages: 69-75
- DOI
  10.1016/j.bbrep.2018.07.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09025, KAKENHI-PROJECT-18H02835, KAKENHI-PROJECT-16K09860, KAKENHI-PROJECT-18H02698, KAKENHI-PROJECT-26290051
[Journal Article] Emetine elicits apoptosis of intractable B-cell lymphoma cells with MYC rearrangement through inhibition of glycolytic metabolism.2017
- Author(s)
  Aoki T, Shimada K, Sakamoto A, Sugimoto K, Morishita T, Kojima Y, Shimada S, Kato S, Iriyama C, Kuno S, Harada Y, Tomita A, Hayakawa F, Kiyoi H.
- Journal Title
  
  Oncotarget.
  
  Volume: 8 Issue: 8 Pages: 13085-13098
- DOI
  10.18632/oncotarget.14393
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26860724, KAKENHI-PROJECT-15K09473, KAKENHI-PROJECT-15K09472
[Journal Article] YM155 induces apoptosis through proteasome-dependent degradation of MCL-1 in primary effusion lymphoma.2017
- Author(s)
  Kojima Y, Hayakawa F, Morishita T, Sugimoto K, Minamikawa Y, Iwase M, Yamamoto H, Hirano D, Imoto N, Shimada K, Okada S, Kiyoi H
- Journal Title
  
  Pharmacol Res.
  
  Volume: in press Pages: 242-251
- DOI
  10.1016/j.phrs.2017.04.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26860724, KAKENHI-PROJECT-16K08742, KAKENHI-PROJECT-17K09921, KAKENHI-PROJECT-17K09922, KAKENHI-PROJECT-15K09472
[Journal Article] Malignant lymphoma with cardiac involvement2017
- Author(s)
  Terakura S, Onji M, Iriyama C, Goto T, Ushijima Y, Shimada K, Ishikawa Y, Nishida T, Hayakawa F, Murata M, Kiyoi H
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 58 Issue: 3 Pages: 239-242
- DOI
  10.11406/rinketsu.58.239
- NAID
  130005549372
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09472, KAKENHI-PROJECT-15K09497
[Journal Article] High-dose methotrexate therapy significantly improved survival of adult acute lymphoblastic leukemia: a phase III study by JALSG2017
- Author(s)
  Sakura T、Hayakawa F、Sugiura I、Murayama T、Imai K、Usui N、Fujisawa S、Yamauchi T、Yujiri T、Kakihana K、Ito Y、Kanamori H、Ueda Y、Miyata Y、Kurokawa M、Asou N、Ohnishi K、Ohtake S、Kobayashi Y、Matsuo K、Kiyoi H、Miyazaki Y、Naoe T
- Journal Title
  
  Leukemia
  
  Volume: 32 Issue: 3 Pages: 626-632
- DOI
  10.1038/leu.2017.283
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09921, KAKENHI-PROJECT-17H04209, KAKENHI-PROJECT-15K09472, KAKENHI-PROJECT-18K08358, KAKENHI-PROJECT-16K09865
[Journal Article] 改訂造血器腫瘍WHO分類2016~概要と意義～　急性リンパ性白血病2017
- Author(s)
  早川文彦
- Journal Title
  
  血液フロンティア
  
  Volume: 27 Pages: 387-391
- Data Source
  KAKENHI-PROJECT-15K09472
[Journal Article] PAX5 tyrosine phosphorylation by SYK co-operatively functions with its serine phosphorylation to cancel the PAX5-dependent repression of BLIMP1: A mechanism for antigen-triggered plasma cell differentiation.2016
- Author(s)
  Inagaki Y, Hayakawa F, Hirano D, Kojima Y, Morishita T, Yasuda T, Naoe T, Kiyoi H
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 475 Issue: 2 Pages: 176-181
- DOI
  10.1016/j.bbrc.2016.05.067
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09472, KAKENHI-PROJECT-16K20973
[Journal Article] SPIB is a novel prognostic factor in diffuse large B-cell lymphoma that mediates apoptosis via the PI3K-AKT pathway.2016
- Author(s)
  2.Takagi Y, Shimada K*, Shimada S, Sakamoto A, Naoe T, Nakamura S, Hayakawa F, Tomita A, Kiyoi H.
- Journal Title
  
  Cancer Sci.
  
  Volume: 107 Issue: 9 Pages: 1270-1280
- DOI
  10.1111/cas.13001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26860724, KAKENHI-PROJECT-15K09472, KAKENHI-PROJECT-15K09473, KAKENHI-PROJECT-26242049
[Journal Article] 染色体転座・遺伝子再構成による白血病発症機序2016
- Author(s)
  早川文彦
- Journal Title
  
  日本臨床
  
  Volume: 74 Pages: 222-226
- Data Source
  KAKENHI-PROJECT-15K09472
[Journal Article] 急性リンパ性白血病におけるゲノム解析と免疫療法2016
- Author(s)
  早川文彦　村田誠
- Journal Title
  
  血液内科
  
  Volume: 73 Pages: 592-597
- Data Source
  KAKENHI-PROJECT-15K09472
[Journal Article] BLNK is a selective target of repression by PAX5-PML in the differentiation block that leads to the development of acute lymphoblastic leukemia.2016
- Author(s)
  Imoto N, Hayakawa F, Kurahashi S, Morishita T, Kojima Y, Yasuda T, Sugimoto K, Tsuzuki S, Naoe T, Kiyoi H.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 291 Issue: 9 Pages: 4723-31
- DOI
  10.1074/jbc.m115.637835
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09472, KAKENHI-PROJECT-15K09492, KAKENHI-PROJECT-25293218
[Journal Article] Development and analysis of patient derived xenograft mouse models in intravascular large B-cell lymphoma. Leukemia.2016
- Author(s)
  Shimada K, Shimada S, Sugimoto K, Nakatochi M, Suguro M, Hirakawa A, Hocking TD, Takeuchi I, Tokunaga T, Takagi Y, Sakamoto A, Aoki T, Naoe T, Nakamura S, Hayakawa F, Seto M, Tomita A, Kiyoi H
- Journal Title
  
  Leukemia
  
  Volume: in press Issue: 7 Pages: 1568-1579
- DOI
  10.1038/leu.2016.67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09472, KAKENHI-PROJECT-26860724
[Journal Article] Wnt signaling is associated with cell survival in the interaction between acute myeloid leukemia cells and stromal cells.2016
- Author(s)
  Niwa Y, Minami Y, Abe A, Hayakawa F, Yamada K, Naoe T
- Journal Title
  
  Leukemia and lymphoma
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09472
[Journal Article] 白血病における遺伝子ゲノム研究の動向2016
- Author(s)
  早川文彦
- Journal Title
  
  日本臨床
  
  Volume: 74 Pages: 446-450
- Data Source
  KAKENHI-PROJECT-15K09472
[Journal Article] Wnt signaling is associated with cell survival in the interaction between acute myeloid leukemia cells and stromal cells.2016
- Author(s)
  Niwa Y, Minami Y, Abe A, Hayakawa F, Yamada K, Naoe T
- Journal Title
  
  Leukemia and lymphoma
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293218
[Journal Article] Small-molecule Hedgehog inhibitor attenuates the leukemia-initiation potential of acute myeloid leukemia cells.2016
- Author(s)
  Fukushima N, Minami Y, Kakiuchi S, Kuwatsuka Y, Hayakawa F, Jamieson C, Kiyoi H, Naoe T.
- Journal Title
  
  Cancer Sci
  
  Volume: 107 Issue: 10 Pages: 1422-1429
- DOI
  10.1111/cas.13019
- NAID
  120005898583
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860346, KAKENHI-PROJECT-15K09472
[Journal Article] The photosensitizer verteporfin has light-independent anti-leukemic activity for Ph-positive acute lymphoblastic leukemia and synergistically works with dasatinib.2016
- Author(s)
  Morishita T, Hayakawa F, Sugimoto K, Iwase M, Yamamoto H, Hirano D, Kojima Y, Imoto N, Naoe T, Kiyoi H.
- Journal Title
  
  Oncotarget.
  
  Volume: 7 Issue: 35 Pages: 56241-56252
- DOI
  10.18632/oncotarget.11025
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09472
[Journal Article] Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults2016
- Author(s)
  Takahiko Yasuda, Shinobu Tsuzuki, Masahito Kawazu, Fumihiko Hayakawa, Shinya Kojima, Toshihide Ueno, Naoto Imoto, Shinji Kohsaka, Akiko Kunita, Koichiro Doi, Toru Sakura, Toshiaki Yujiri, Eisei Kondo, Katsumichi Fujimaki, Yasunori Ueda, Yasutaka Aoyama, Shigeki Ohtake, Junko Takita, Eirin Sai, Masafumi Taniwaki, et al.
- Journal Title
  
  Nature genetics
  
  Volume: in press Issue: 5 Pages: 409-417
- DOI
  10.1038/ng.3535
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09472, KAKENHI-PROJECT-25461432, KAKENHI-PROJECT-26670493, KAKENHI-PROJECT-25860289, KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-26293242, KAKENHI-PROJECT-26461421, KAKENHI-PROJECT-16K09856
[Journal Article] Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cells2015
- Author(s)
  Sugimoto K, Hayakawa F, Shimada S, Morishita T, Shimada K, Katakai T, Tomita A, Kiyoi H, Naoe T
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Issue: 1 Pages: 13054-13054
- DOI
  10.1038/srep13054
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09472, KAKENHI-PROJECT-15K09473, KAKENHI-PLANNED-24111005, KAKENHI-PROJECT-25670101, KAKENHI-PROJECT-25293218
[Journal Article] Anti-cancer fatty-acid derivative induces autophagic cell death through modulation of PKM isoforms expression profile mediated by bcr-abl in chronic myeloid leukemia.2015
- Author(s)
  Shinohara H, Taniguchi K, Kumazaki M, Yamada N, Ito Y, Otsuki Y, Uno B, Hayakawa F, Minami Y, Naoe T, Akao Y.
- Journal Title
  
  Cancer Letters
  
  Volume: 360 Issue: 1 Pages: 28-38
- DOI
  10.1016/j.canlet.2015.01.039
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-25118711, KAKENHI-PROJECT-25293218, KAKENHI-PROJECT-25461412, KAKENHI-PROJECT-25462003
[Journal Article] Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group.2014
- Author(s)
  Hayakawa F, Sakura T, Yujiri T, Kondo E, Fujimaki K, Sasaki O, Miyatake J, Handa H, Ueda Y, Aoyama Y, Takada S, Tanaka Y, Usui N, Miyawaki S, Suenobu S, Horibe K, Kiyoi H, Ohnishi K, Miyazaki Y, Ohtake S, Kobayashi Y, Matsuo K, Naoe T
- Journal Title
  
  Blood Cancer Journal
  
  Volume: 4 Issue: 10 Pages: 252-252
- DOI
  10.1038/bcj.2014.72
- NAID
  120006987091
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25118711, KAKENHI-PROJECT-25461442, KAKENHI-PROJECT-26461421
[Journal Article] Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group.2014
- Author(s)
  Hayakawa F, Sakura T, Yujiri T, Kondo E, Fujimaki K, Sasaki O, Miyatake J, Handa H, Ueda Y, Aoyama Y, Takada S, Tanaka Y, Usui N, Miyawaki S, Suenobu S, Horibe K, Kiyoi H, Ohnishi K, Miyazaki Y, Ohtake S, Kobayashi Y, Matsuo K, Naoe T; Japan Adult Leukemia Study Group (JALSG).
- Journal Title
  
  Blood Cancer J
  
  Volume: 4
- NAID
  120006987091
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293218
[Journal Article] Development of acute pure red cell aplasia after deferasirox administration in two cases of myelodysplastic syndrome.2014
- Author(s)
  Hayakawa F, Tomita A, Naoe T
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 55 Pages: 445-449
- NAID
  130004920671
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25118711
[Journal Article] Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group.2014
- Author(s)
  Hayakawa F, Sakura T, Yujiri T, Kondo E, Fujimaki K, Sasaki O, Miyatake J, Handa H, Ueda Y, Aoyama Y, Takada S, Tanaka Y, Usui N, Miyawaki S, Suenobu S, Horibe K, Kiyoi H, Ohnishi K, Miyazaki Y, Ohtake S, Kobayashi Y, Matsuo K, Naoe T; Japan Adult Leukemia Study Group (JALSG).
- Journal Title
  
  Blood Cancer J
  
  Volume: 4
- NAID
  120006987091
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670449
[Journal Article] Development of acute pure red cell aplasia after deferasirox administration in two cases of myelodysplastic syndrome.2014
- Author(s)
  Hayakawa F, Tomita A, Naoe T
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 55(4) Pages: 445-449
- NAID
  130004920671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293218
[Journal Article] Development of acute pure red cell aplasia after deferasirox administration in two cases of myelodysplastic syndrome.2014
- Author(s)
  Hayakawa F, Tomita A, Naoe T
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 55（4） Pages: 445-449
- NAID
  130004920671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670449
[Journal Article] GATA2 zincﬁnger 2 mutation found in acute myeloid leukemia impairs myeloid differentiation2013
- Author(s)
  Niimi K, Hayakawa F,他6名
- Journal Title
  
  Leuk. Res. Rep
  
  Volume: 2 Pages: 21-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591381
[Journal Article] A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases2013
- Author(s)
  Fumihiko Hayakawa, Keiki Sugimoto, Yasuo Harada, Norikazu Hashimoto, Naoto Ohi, Shingo Kurahashi, Tomoki Naoe
- Journal Title
  
  Blood Cancer Journal
  
  Volume: 3 Issue: 11 Pages: e166-e166
- DOI
  10.1038/bcj.2013.63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591381, KAKENHI-PUBLICLY-25118711, KAKENHI-PROJECT-25293218
[Journal Article] GATA2 zincfinger2mutationfoundinacutemyeloidleukemia impairs myeloiddifferentiation2013
- Author(s)
  Keiko Niimi, Hitoshi Kiyoi, Yuichi Ishikawa, Fumihiko Hayakawa, Shingo Kurahashi, Rika Kihara, Akihiro Tomita, Tomoki Naoe
- Journal Title
  
  Leukemia ResearchReports
  
  Volume: 2 Issue: 1 Pages: 21-25
- DOI
  10.1016/j.lrr.2013.02.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591381, KAKENHI-PROJECT-24591387, KAKENHI-PROJECT-24591388, KAKENHI-PUBLICLY-25118711
[Journal Article] A novel STAT inhibitor, OPB-31121, has a significant anti-tumor effect on leukemia with STAT-addictive oncokinases2013
- Author(s)
  Hayakawa F他6名
- Journal Title
  
  Blood Cancer Journal
  
  Volume: 3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591381
[Journal Article] B cell receptor-ERK1/2 signal cancels PAX5-dependent repression of BLIMP1 through PAX5 phosphorylation: a mechanism of antigen-triggering plasma cell differentiation2012
- Author(s)
  Takahiko Yasuda, Fumihiko Hayakawa, Shingo Kurahashi, Keiki Sugimoto , Yosuke Minami, Akihiro Tomita, Tomoki Naoe
- Journal Title
  
  Journal of Immunology
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591381
[Journal Article] B cell receptor-ERK1/2 signal cancels PAX5-dependent repression of BLIMP1 through PAX5 phosphorylation: a mechanism of antigen-triggering plasma cell differentiation2012
- Author(s)
  Takahiko Yasuda, Fumihiko Hayakawa, Shingo Kurahashi, Keiki Sugimoto , Yosuke Minami, Akihiro Tomita, Tomoki Naoe
- Journal Title
  
  Journal of Immunology
  
  Volume: 188 Issue: 12 Pages: 6127-34
- DOI
  10.4049/jimmunol.1103039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591381, KAKENHI-PROJECT-23659487, KAKENHI-PROJECT-24591388
[Journal Article] B cell receptor-ERK1/2 signal cancels PAX5-dependent repression of BLIMP1 through PAX5 phosphorylation : a mechanism of antigen-triggering plasma cell differentiation2012
- Author(s)
  Yasuda T,Hayakawa F,他6名
- Journal Title
  
  J Immunol
  
  Volume: 188 Pages: 6127-6134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591381
[Journal Article] Missense mutations in PML-RARA critical for the lack of responsiveness to arsenic trioxide treatment2011
- Author(s)
  Goto E, Hayakawa F他7名
- Journal Title
  
  Blood
  
  Volume: 118 Pages: 1600-1609
- Data Source
  KAKENHI-PROJECT-23591381
[Journal Article] The mTOR inhibitor, everolimus(RAD001), overcomes resistance to imatinib in quiescent Ph-positive acute lymphoblastic leukemia cells2011
- Author(s)
  Kuwatsuka Y, Naoe T, et al
- Journal Title
  
  Blood Cancer Journal
  
  Volume: 1 Issue: 5 Pages: 1-7
- DOI
  10.1038/bcj.2011.16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390192, KAKENHI-PROJECT-22790908, KAKENHI-PROJECT-23591381
[Journal Article] PAX5-PML acts as a dual dominant-negative form of both PAX5 and PML2011
- Author(s)
  Kurahashi S, Hayakawa F
- Journal Title
  
  Oncogene In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591117
[Journal Article] The mTOR inhibitor, everolimus (RAD001), overcomes resistance to imatinib in quiescent Phpositiveacute lymphoblastic leukemia cells2011
- Author(s)
  Kuwatsuka Y, Hayakawa F他8名
- Journal Title
  
  Blood Cancer J
  
  Volume: 1
- Data Source
  KAKENHI-PROJECT-23591381
[Journal Article] WHO分類第4版における急性骨髄性白血病2009
- Author(s)
  早川文彦, 他
- Journal Title
  
  Trends in Hematological Malignancies 1
  
  Pages: 40-41
- Data Source
  KAKENHI-PROJECT-20591117
[Journal Article] Acetylation of PML is involved in histone deacetylase inhibitor-mediated apoptosis.2009
- Author(s)
  Fumihiko Hayakawa
- Journal Title
  
  The Journal of Biological Chemistry 283
  
  Pages: 24420-24425
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591117
[Journal Article] Acetylation of PML is involved in histone deacetylase Inhibitor-mediated apoptosis.2008
- Author(s)
  Hayakawa F, Abe A
- Journal Title
  
  J Biol Chem. 283
  
  Pages: 24420-24425
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591117
[Journal Article] SFK-STAT pathway : an alternative and important way to malignancies.2006
- Author(s)
  Hayakawa F
- Journal Title
  
  Annals New York academy of Sciences 1086
  
  Pages: 213-222
- Data Source
  KAKENHI-PROJECT-18790649
[Patent] 悪性リンパ腫のインビトロ腫瘍細胞モデル及びその利用2012
- Inventor(s)
  早川文彦他4名
- Industrial Property Rights Holder
  名古屋大学他4名
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-137462
- Filing Date
  2012-06-19
- Overseas
- Data Source
  KAKENHI-PROJECT-23591381
[Patent] 急性骨髄性白血病治療剤の候補物質を同定する方法2006
- Inventor(s)
  直江知樹, 早川文彦, 岡本充功
- Industrial Property Rights Holder
  名古屋大学
- Industrial Property Number
  2006-155281
- Filing Date
  2006-06-02
- Data Source
  KAKENHI-PROJECT-18790649
[Presentation] ネララビン併用化学療法による治療成績改善と重篤な神経障害　JALSG T-ALL213-O2023
- Author(s)
  早川　文彦　他（15人中1番目）
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K19505
[Presentation] AYA世代のがん研究における最新の知見　Pre-B細胞性急性リンパ球性白血病における転写制御ネットワーク2021
- Author(s)
  4.都築忍, 安田貴彦, 河津正人, 上野敏秀, カルナン・シバスンダラン , 太田明伸, 真田昌, 永井宏和, 冨田章裕, 高橋義行, 宮崎泰司, 松村到, 清井仁, 細川好孝, 間野博行, 早川文彦
- Organizer
  第80回日本癌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19505
[Presentation] B細胞性急性リンパ性白血病　―最近の知見と今後の治療―2021
- Author(s)
  1.早川文彦
- Organizer
  第83回日本血液学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19505
[Presentation] Template switchingによるF8エクソン15欠損が認められた重症血友病A症例2020
- Author(s)
  所真昼, 田村彰吾, 鈴木伸明, 大平晃也, 河島史華, 早川友梨, 早川文彦, 岡本修一, 兼松毅, 勝見章, 松下正, 小嶋哲人
- Organizer
  第42回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02835
[Presentation] スプライシング異常を引き起こす血液凝固第IX因子遺伝子イントロン1内の深部大挿入変異2020
- Author(s)
  河島史華, 田村彰吾, 鈴木伸明, 大平晃也, 所真昼, 早川友梨, 早川文彦, 岡本修一, 兼松毅, 高木明, 松下正, 小嶋哲人
- Organizer
  第42回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02835
[Presentation] 悪性リンパ腫の腫瘍関連線維芽細胞由来のエクソソームはHDAC阻害剤耐性を誘導する2020
- Author(s)
  加賀谷裕介, 島田和之, 久納俊祐, 疋田智也, 坂本明彦, 早川文彦, 小根山千歳, 清井仁
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02835
[Presentation] C末端伸長変異型Factor XIにおける分泌異常の解析2020
- Author(s)
  早川友梨, 田村彰吾, 鈴木伸明, 大平晃也, 所真昼, 河島史華, 早川文彦, 高木明, 鈴木敦夫, 岡本修一, 兼松毅, 松下正, 小嶋哲人
- Organizer
  第42回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02835
[Presentation] 当施設における新生児・乳幼児に対するエミシズマブの使用経験2020
- Author(s)
  兼松毅, 鈴木伸明, 岡本修一, 鈴木敦夫, 田村彰吾, 早川文彦, 小嶋哲人, 清井仁, 松下正
- Organizer
  第42回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02835
[Presentation] Endothelial colony forming cells(ECFCs)樹立法の標準化への試み2020
- Author(s)
  岡本修一, 鈴木伸明, 兼松毅, 鈴木敦夫, 大平晃也, 所真昼, 早川友梨, 田村彰吾, 早川文彦, 清井仁, 小嶋哲人, 松下正
- Organizer
  第42回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02835
[Presentation] MEF2D融合タンパクの分解を誘導する薬剤をスクリーニングするシステムの開発2019
- Author(s)
  Naoyuki Tange, Fumihiko Hayakawa, Takahiko Yasuda, Hideyuki Yamamoto, Daiki Hirano, Shinobu Tsuzuki, Hitoshi Kiyoi.
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02835
[Presentation] 1.Staurosporine induces caspase-dependent proteolysis of MEF2D-fusion protein and cell death selective to MEF2D-fusion-positive ALL cells.2019
- Author(s)
  Naoyuki Tange, Fumihiko Hayakawa, Takahiko Yasuda, Hideyuki Yamamoto, Daiki Hirano, Shinobu Tsuzuki, Tomoki Naoe, Hitoshi Kiyoi.
- Organizer
  61st American Society of Hematology Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02835
[Presentation] ZNF384-Fusion Proteins Have High Affinity to EP300, Which Increases Their Transcriptional Activities2018
- Author(s)
  Hideyuki Yamamoto, Fumihiko Hayakawa, Takahiko Yasuda, Yuka Minamikawa, Naoyuki Tange, Daiki Hirano, Yuki Kojima, Takanobu Morishita, Shinobu Tsuzuki, Hiroyuki Mano, Tomoki Naoe, Hitoshi Kiyoi
- Organizer
  60th ASH Annual Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02835
[Presentation] 成人B細胞性急性リンパ性白血病のゲノム学的・臨床的な特徴2018
- Author(s)
  安田貴彦, 西島大, 小島進也, 河津正人, 上野敏秀, 都築忍, 清井仁, 松村到, 宮崎泰司, 堀部敬三, 間野博行, 直江知樹, 眞田昌, 早川文彦
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02835
[Presentation] Genomic and Clinical Characterization of Adult Ph-Negative B-Cell Acute Lymphoblastic Leukemia2018
- Author(s)
  Takahiko Yasuda, Dai Nishijima, Shinya Kojima, Masahito Kawazu, Toshihide Ueno, Shinobu Tsuzuki, Hitoshi Kiyoi, Itaru Matsumura, Yasushi Miyazaki, Keizo Horibe, Hiroyuki Mano, Tomoki Naoe, Masashi Sanada, Fumihiko Hayakawa,
- Organizer
  60th ASH Annual Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02835
[Presentation] DUX4-IGH融合遺伝子陽性B細胞急性リンパ性白血病における転写活性解析2018
- Author(s)
  田中庸介, 河津正人, 安田貴彦, 早川文彦, 清井仁, 直江知樹, 間野博行
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02835
[Presentation] ZNF384融合遺伝子による急性リンパ性白血病発症機構の解明2018
- Author(s)
  山本秀行, 早川文彦, 安田貴彦, 南川友香, 丹下直幸, 平野大希, 小島勇貴, 森下喬允, 都築忍, 間野博行, 直江知樹, 清井仁
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02835
[Presentation] High expression of MEF2D-fusion protein by escaping from the regulation by microRNA2017
- Author(s)
  Daiki Hirano, Fumihiko Hayakawa, Takahiko Yasuda, Naoyuki Tange, Hideyuki Yamamoto, Yuki Kojima, Takanobu Morishita, Naoto Imoto, Shinobu Tsuzuki, Hiroyuki Mano, Tomoki Naoe, Hitoshi Kiyoi
- Organizer
  59th annual meeting of american society of hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09472
[Presentation] High expression of MEF2D-fusion protein by escaping from the regulation by microRNA2017
- Author(s)
  平野大希, 早川文彦, 安田貴彦, 山本秀行, 小島勇貴, 森下喬允, 井本直人, 都築忍, 間野博行, 直江知樹, 清井仁
- Organizer
  第７９回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09472
[Presentation] Emetine Elicits Apoptosis of Intractable B-Cell Lymphoma Cells with MYC Rearrangement through Inhibition of Glycolytic Metabolis2016
- Author(s)
  青木智広、島田和之、早川文彦、清井仁、他
- Organizer
  第58回アメリカ血液学会
- Place of Presentation
  米国　サンディエゴ
- Year and Date
  2016-12-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09472
[Presentation] YM155 induces apoptosis through proteasome-dependent degradation of MCL-1 in primary effusion lymphoma.2016
- Author(s)
  小島勇貴、早川文彦、清井仁、他
- Organizer
  第58回アメリカ血液学会
- Place of Presentation
  米国　サンディエゴ
- Year and Date
  2016-12-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09472
[Presentation] Genetic abnormalities of AYA ALL and its treatment strategy by pediatric like protocols.2016
- Author(s)
  早川文彦
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-13
- Invited
- Data Source
  KAKENHI-PROJECT-15K09472
[Presentation] 8.YM155 induces apoptosis through downregulation of MCL-1 in primary effusion lymphoma.2016
- Author(s)
  小島勇貴、早川文彦、清井仁、他
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K09472
[Presentation] Discovering the novel drug targeting tumor-microenvironment for intractable lymphoma.2016
- Author(s)
  青木智広、島田和之、早川文彦、清井仁、他
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K09472
[Presentation] New molecular targets of B-cell acute lymphoblastic leukemia.2016
- Author(s)
  早川文彦、安田貴彦、間野博行
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Invited
- Data Source
  KAKENHI-PROJECT-15K09472
[Presentation] Treatment of acute lymphoblastic leukemia in adolescent and young adult by pediatric protocols2016
- Author(s)
  早川文彦
- Organizer
  第14回日本臨床腫瘍学会学術集会
- Place of Presentation
  神戸国際会議場（（兵庫県神戸市）
- Year and Date
  2016-07-28
- Invited
- Data Source
  KAKENHI-PROJECT-15K09472
[Presentation] Drug repositioning by patient-derived-xenograft screening for the discovery of new cure for PhALL2015
- Author(s)
  森下喬允、早川文彦、小島勇貴、井本直人、稲垣裕一郎、杉本慶樹、直江知樹、清井仁
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県金沢市　ホテル日航金沢
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K09472
[Presentation] Lymph node-associated stromal fibroblasts support B-cell lymphoma cells via the PI3K pathway.2015
- Author(s)
  坂本明彦、島田和之、片山幸、早川文彦、冨田章裕、清井仁.
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県立音楽堂（石川県金沢市）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] A Photosensitizer Verteporfin Has Light-Independent Anti-Leukemic Activity for Ph-Positive Acute Lymphoblastic Leukemia and Synergistically Works with Dasatinib in Vivo2015
- Author(s)
  Takanobu Morishita, Fumihiko Hayakawa, Keiki Sugimoto, Daiki Hirano, Yuki Kojima, Naoto Imoto, Yuichiro Inagaki, Tomoki Naoe and Hitoshi Kiyoi
- Organizer
  57th ASH Annual Meeting and Exposition
- Place of Presentation
  アメリカ　フロリダ州オーランド　Orange County Convention Center
- Year and Date
  2015-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09472
[Presentation] リンパ節関連の間質性線維芽細胞は液性因子を分泌することでB細胞リンパ腫細胞を支持する.2015
- Author(s)
  坂本明彦、島田和之、片山幸、早川文彦、冨田章裕、清井仁.
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] 1353 Development of FF-10101, a Novel Irreversible FLT3 Inhibitor, Which Overcomes Drug Resistance Mutations.2015
- Author(s)
  Toshiyuki Nakatani,Ken Uda, Takeshi Yamaura, Masaru Takasaki, Akimi Akashi, Fangli Chen, , Yuichi Ishikawa, Fumihiko Hayakawa, Shinji Hagiwara, Hitoshi Kiyoi, and Tomoki Naoe
- Organizer
  57th ASH Annual Meeting and Exposition
- Place of Presentation
  Orange County Convention Center(米国)
- Year and Date
  2015-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] A Photosensitizer Verteporfin Has Light-Independent Anti-Leukemic Activity for Ph-Positive Acute Lymphoblastic Leukemia and Synergistically Works with Dasatinib in Vivo.2015
- Author(s)
  Takanobu Morishita, Fumihiko Hayakawa, Keiki Sugimoto, Daiki Hirano, Yuki Kojima, Naoto Imoto, Yuichiro Inagaki, Tomoki Naoe and Hitoshi Kiyoi.
- Organizer
  57th ASH Annual Meeting and Exposition
- Place of Presentation
  Orange County Convention Center(米国)
- Year and Date
  2015-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] Lymph node-associated stromal fibroblasts as a potential source of humoral factors to support B-cell lymphoma cells via the phosphatidylinositol 3-kinase pathway2015
- Author(s)
  坂本明彦、島田和之、片山幸、早川文彦、冨田章裕、清井仁
- Organizer
  第44回国際実験血液学会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2015-09-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] Drug repositioning by patient-derived-xenograft screening for the discovery of new cure for PhALL.2015
- Author(s)
  森下喬允、早川文彦、小島勇貴、井本直人、稲垣裕一郎、杉本慶樹、直江知樹、清井仁
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県立音楽堂（石川県金沢市）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] Ph陽性ALL新規治療薬発見のためのPDXスクリーニングによるドラッグリポジショニング2015
- Author(s)
  森下喬允、早川文彦、杉本慶樹、直江知樹、清井仁
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  愛知県名古屋市　名古屋国際会議場
- Year and Date
  2015-10-13
- Data Source
  KAKENHI-PROJECT-15K09472
[Presentation] SPIB expression is a novel poor prognostic factor in DLBCL.2015
- Author(s)
  髙木雄介、島田和之、島田聡子、早川文彦、坂本明彦、中村栄男、冨田章裕、清井仁.
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県立音楽堂（石川県金沢市）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] Ph陽性ALL新規治療薬発見のためのPDXスクリーニングによるドラッグリポジショニング.2015
- Author(s)
  森下喬允、早川文彦、杉本慶樹、直江知樹、清井仁.
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] AYA ALL に対する小児プロトコールの有効性と認容の検討：JALSG ALL202-U 研究より2014
- Author(s)
  早川文彦
- Organizer
  第56回日本小児血液・がん学会学術集会シンポジウム
- Place of Presentation
  岡山県岡山市　岡山コンベンションセンター
- Year and Date
  2014-11-28
- Invited
- Data Source
  KAKENHI-PUBLICLY-25118711
[Presentation] A novel STAT inhibitor, OPB-31121, has a significant anti-tumor effect on STAT-dependent leukemia.2013
- Author(s)
  Fumihiko Hayakawa, Keiki Sugimoto, Shingo Kurahashi, Tomoki Naoe.
- Organizer
  日本血液学会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] Tratment with Hedgehog inhibitor,PF-04449913, atteuates leukemia-initiation potential in acute mveloid leukemia cells2013
- Author(s)
  Nobuaki Fukushima,Yosuke Minami,Fumihiko Hayakawa,Hitoshi Kiyoi, Anil Sadarangani, PhD3*, Catriona HM Jamieson,Tomoki Naoe
- Organizer
  米国血液学会
- Place of Presentation
  ニューオリンズ
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] リンパ腫細胞環境をターゲットする薬剤開発2013
- Author(s)
  杉本慶樹、早川文彦　直江知樹
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-25670449
[Presentation] PAX5-PML induces pro B acute lymphoblastic leukemia in mice2013
- Author(s)
  井本直人　倉橋信悟　早川文彦　安田貴彦　杉本慶樹　都築忍　直江知樹
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  ロイトン札幌　札幌市
- Data Source
  KAKENHI-PUBLICLY-25118711
[Presentation] Drug Development Targeting Microenvironment for Malignant Lymphoma2012
- Author(s)
  Keiki Sugimoto, Fumihiko Hayakawa, Takahiko Yasuda, and Tomoki Naoe
- Organizer
  American Society of Hematology Annual Meeting
- Place of Presentation
  アトランタ　米国
- Data Source
  KAKENHI-PROJECT-23591381
[Presentation] Feasibility and safety of pediatric-type therapy for acute lymphoblastic leukemia in adolescences and young adults : Interim analysis of JALSG ALL202-U2012
- Author(s)
  Hayakawa F
- Organizer
  25th Anniversary International Symposium of Japan Adult Leukemia Study Group
- Place of Presentation
  東京都千代田区国際フォーラム
- Year and Date
  2012-06-24
- Invited
- Data Source
  KAKENHI-PROJECT-23591381
[Presentation] Development of growth signal inhibitors for hematopoietic malignancies2011
- Author(s)
  Fumihiko Hayakawa, Keiki Sugimoto, Shingo Kurahashi, Takumi Sumida, Tomoki Naoe
- Organizer
  第70回日本癌学会学術総会(招待講演)
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23591381
[Presentation] A novel STAT3 inhibitor OPB-31121 induces tumor-specific growth inhibition in a wide range of hematopoietic malignancies2011
- Author(s)
  Fumihiko Hayakawa, Keiki Sugimoto, Shingo Kurahashi, Takumi Sumida, Tomoki Naoe
- Organizer
  53rd Annual Meeting of the American Society of Hematology
- Place of Presentation
  米国サンディエゴ
- Year and Date
  2011-12-11
- Data Source
  KAKENHI-PROJECT-23591381
[Presentation] Development of growth signal inhibitors for hematopoietic malignancies2011
- Author(s)
  Hayakawa F
- Organizer
  第70回日本癌学会学術総会腫瘍別シンポジウム
- Place of Presentation
  名古屋白鳥国際会議場
- Year and Date
  2011-11-10
- Invited
- Data Source
  KAKENHI-PROJECT-23591381
[Presentation] B cell receptor-ERK1/2 signal cancels PAX5-dependent repression of BLIMP1 through PAX5 phosphorylation: a mechanism of antigen-triggering plasma cell differentiation2011
- Author(s)
  Takahiko Yasuda, Fumihiko Hayakawa, Shingo Kurahashi, Keiki Sugimoto , Tomoki Naoe
- Organizer
  53rd Annual Meeting of the American Society of Hematology
- Place of Presentation
  San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-23591381
[Presentation] A novel STAT3 inhibitor OPB-31121 induces tumor-specific growth inhibition in a wide range of hematopoietic malignancies2011
- Author(s)
  Fumihiko Hayakawa, Keiki Sugimoto, Shingo Kurahashi, Takumi Sumida, Tomoki Naoe
- Organizer
  53rd Annual Meeting of the American Society of Hematology
- Place of Presentation
  San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-23591381
[Presentation] A novel direct STAT3 inhibitor OPB-31121 induces tumor-specific growth inhibition in a wide range of hematopoietic malignancies and effectively suppresses the chemotherapy resistant quiescent cells in vivo. The American Society of Hematology2010
- Author(s)
  Hayakawa F, Sugimoto K
- Organizer
  52nd Annual Meeting
- Place of Presentation
  Orlando, FL, USA
- Year and Date
  2010-12-06
- Data Source
  KAKENHI-PROJECT-20591117
[Presentation] PAX5-PML acts as a dual dominant- negative form of PAX5 and PML. The American Society of Hematology2010
- Author(s)
  Kurahashi S, Hayakawa F
- Organizer
  52nd Annual Meeting
- Place of Presentation
  Orlando, FL, USA
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-20591117
[Presentation] PAX5 phosphorylation by MAP kinase signal potentially suppresses PAX5 function and might be a trigger of the plasma cell differentiation.2010
- Author(s)
  Yasuda T, Hayakawa F
- Organizer
  The American Society of Hematology, 52nd Annual Meeting.
- Place of Presentation
  Orlando, FL, USA
- Year and Date
  2010-12-06
- Data Source
  KAKENHI-PROJECT-20591117
[Presentation] PAX5-PML acts as a dual dominant-negative form of both PAX5 and PML2009
- Author(s)
  Fumihiko Hayakawa, et al
- Organizer
  5th International Symposium on Acute Promyelocytic Leukemia
- Place of Presentation
  ローマ
- Year and Date
  2009-09-25
- Data Source
  KAKENHI-PROJECT-20591117
[Presentation] PAX5-PML acts as a dual dominant- negative form of PAX5 and PML.2009
- Author(s)
  Hayakawa F, Kurahashi S
- Organizer
  5th International Symposium on ACUTE PROMYELOCYTIC LEUKEMIA
- Place of Presentation
  Rome, Italy
- Year and Date
  2009-09-25
- Data Source
  KAKENHI-PROJECT-20591117
[Presentation] 腫瘍抑制因子PMLアセチル化による機能制御2007
- Author(s)
  早川文彦
- Organizer
  日本血液学会・日本臨床血液学会合同総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-12
- Data Source
  KAKENHI-PROJECT-18790649
[Presentation] Acetylation of PML Plays a Key Role in Histone Deacetylase Inhibitor-Mediated Apoptosis through Enhanced PML Sumoylation.2007
- Author(s)
  早川文彦
- Organizer
  米国血液学会年次総会
- Place of Presentation
  アトランタ(アメリカ)
- Year and Date
  2007-12-08
- Data Source
  KAKENHI-PROJECT-18790649
[Presentation] B細胞受容体シグナル経路によるリン酸化を介したPAX5の機能調節
- Author(s)
  稲垣裕一郎、早川文彦、清井仁
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市北区）
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] AYA ALL に対する小児プロトコールの有効性と認容の検討：JALSG ALL202-U 研究より
- Author(s)
  早川文彦
- Organizer
  第56回日本小児血液・がん学会学術集会シンポジウム
- Place of Presentation
  岡山コンベンションセンター（岡山県岡山市北区）
- Year and Date
  2014-11-28 – 2014-11-30
- Data Source
  KAKENHI-PROJECT-25670449
[Presentation] PAX5-PML induces pro B acute lymphoblastic leukemia in mice.
- Author(s)
  moto N, Kurahashi S, Hayakawa F, Yasuda T, Sugimoto K, Tsuzuki S, Naoe T, Kiyoi H.
- Organizer
  The American Society of Hematology 54th Annual Meeting.
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-12-05 – 2014-12-09
- Data Source
  KAKENHI-PUBLICLY-25118711
[Presentation] Markedly Improved Outcome and Acceptable Toxicity in Adolescents and Young Adults with Acute Lymphoblastic Leukemia by Treatment with a Pediatric Protocol: a Phase Ⅱ Study by the Japan Adult Leukemia Study Group.
- Author(s)
  Hayakawa Fumihiko、 Toru Sakura, Toshiaki Yujiri, Eisei Kondo, Katsumichi Fujimaki, Shuichi Miyawaki, So-ichi Suenobu, Shigeki Ohtake, Yukio Kobayashi, keitaro Matsuo, and Tomoki Naoe
- Organizer
  第5回日本血液学会（JSH)国際シンポジウム
- Place of Presentation
  アクトシティ浜松（静岡県浜松市中区）
- Year and Date
  2014-05-24 – 2014-05-25
- Data Source
  KAKENHI-PROJECT-25670449
[Presentation] AYA ALL に対する小児プロトコールの有効性と認容の検討：JALSG ALL202-U 研究より
- Author(s)
  早川文彦
- Organizer
  第56回日本小児血液・がん学会学術集会シンポジウム
- Place of Presentation
  岡山コンベンションセンター（岡山県岡山市北区）
- Year and Date
  2014-11-28 – 2014-11-30
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] Biological and genetic analyses of intravascular large B-cell lymphoma using xenograft mouse model.
- Author(s)
  島田和之、島田聡子、杉本慶樹、早川文彦、片山幸、平川晃弘、中村栄男、瀬戸加大、直江知樹、冨田章裕、清井仁
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市北区）
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group
- Author(s)
  Fumihiko Hayakawa
- Organizer
  The 5th JSH International Symposium
- Place of Presentation
  静岡県浜松市　アクトシティ浜松コングレスセンター
- Year and Date
  2014-05-23 – 2014-05-24
- Invited
- Data Source
  KAKENHI-PUBLICLY-25118711
[Presentation] PAX5 Tyrosine Phosphorylation By Syk Co-Operatively Works with Its Serine Phosphorylation By ERK1/2 and Cancels PAX5-Dependent Repression of BLIMP1: A Mechanism of Antigen-Triggering Plasma Cell Differentiation through B Cell Receptor Signal.
- Author(s)
  稲垣裕一郎、早川文彦、井本直人、森下喬允、直江知樹、清井仁
- Organizer
  第56回米国血液学会
- Place of Presentation
  Moscone Center （サンフランシスコ、米国）
- Year and Date
  2014-12-06 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] マウスモデルでのPAX5-PMLによる急性リンパ性白血病の解析
- Author(s)
  井本直人、倉橋信悟、早川文彦、安田貴彦、清井　仁
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市北区）
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] B細胞受容体シグナルによるチロシンリン酸化を介したPAX5の機能調節
- Author(s)
  稲垣祐一郎　早川文彦　清井仁
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪府大阪市　大阪国際会議場
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PUBLICLY-25118711
[Presentation] PAX5-PML Induces Pro B Acute Lymphoblastic Leukemia In Mice
- Author(s)
  井本直人、倉橋信悟、早川文彦、安田貴彦、清井　仁・・・他
- Organizer
  第5回日本血液学会（JSH)国際シンポジウム
- Place of Presentation
  アクトシティ浜松（静岡県浜松市中区）
- Year and Date
  2014-05-24 – 2014-05-25
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] Biological and genetic analyses of intravascular large B-cell lymphoma using xenograft mouse model.
- Author(s)
  島田和之、島田聡子、杉本慶樹、早川文彦、片山幸、平川晃弘、中村栄男、瀬戸加大、直江知樹、冨田章裕、清井仁
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市北区）
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25670449
[Presentation] マウスモデルでのPAX5-PMLによる急性リンパ性白血病の解析
- Author(s)
  井本直人、倉橋信悟、早川文彦、安田貴彦、清井　仁
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市北区）
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25670449
[Presentation] PAX5-PML Induces Pro B Acute Lymphoblastic Leukemia In Mice
- Author(s)
  井本直人、倉橋信悟、早川文彦、安田貴彦、清井　仁、et al
- Organizer
  第5回日本血液学会（JSH)国際シンポジウム
- Place of Presentation
  アクトシティ浜松（静岡県浜松市中区）
- Year and Date
  2014-05-24 – 2015-05-25
- Data Source
  KAKENHI-PROJECT-25670449
[Presentation] PAX5 tyrosine phosphorylation by Syk co-operatively works with its serine phosphorylation by ERK1/2 and cancels PAX5-dependent repression of BLIMP1: a mechanism of antigen-triggering plasma cell differentiation through B cell receptor signal.
- Author(s)
  Inagaki Y, Hayakawa F, Imoto N, Morishita T, Naoe T, Kiyoi H.
- Organizer
  The American Society of Hematology 54th Annual Meeting.
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-12-05 – 2014-12-09
- Data Source
  KAKENHI-PUBLICLY-25118711
[Presentation] Markedly Improved Outcome and Acceptable Toxicity in Adolescents and Young Adults with Acute Lymphoblastic Leukemia by Treatment with a Pediatric Protocol: a Phase Ⅱ Study by the Japan Adult Leukemia Study Group.
- Author(s)
  Hayakawa Fumihiko、 Toru Sakura, Toshiaki Yujiri, Eisei Kondo, Katsumichi Fujimaki, Shuichi Miyawaki, So-ichi Suenobu, Shigeki Ohtake, Yukio Kobayashi, keitaro Matsuo, and Tomoki Naoe
- Organizer
  第5回日本血液学会（JSH)国際シンポジウム
- Place of Presentation
  アクトシティ浜松（静岡県浜松市中区）
- Year and Date
  2014-05-24 – 2014-05-25
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] Development and Analysis of Novel Intravascular Large B-Cell Lymphoma NOD/Shi-Scid IL2R γnull Mouse Xenograft Model.
- Author(s)
  Kazuyuki Shimada, Satoko Shimada, Keiki Sugimoto, Fumihiko Hayakawa, Miyuki Katayama, Akihiro Hirakawa, Yusuke Takagi, Shigeo Nakamura, Masao Seto, Tomoki Naoe, Akihiro Tomita, Hitoshi Kiyoi
- Organizer
  第56回米国血液学会
- Place of Presentation
  Moscone Center （サンフランシスコ、米国）
- Year and Date
  2014-12-06 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-25670449
[Presentation] PAX5 Tyrosine Phosphorylation By Syk Co-Operatively Works with Its Serine Phosphorylation By ERK1/2 and Cancels PAX5-Dependent Repression of BLIMP1: A Mechanism of Antigen-Triggering Plasma Cell Differentiation through B Cell Receptor Signal.
- Author(s)
  稲垣裕一郎、早川文彦、井本直人、森下喬允、直江知樹、清井仁
- Organizer
  第56回米国血液学会
- Place of Presentation
  Moscone Center （サンフランシスコ、米国）
- Year and Date
  2014-12-06 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-25670449
[Presentation] B細胞受容体シグナル経路によるリン酸化を介したPAX5の機能調節
- Author(s)
  稲垣裕一郎、早川文彦、清井仁
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市北区）
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25670449
[Presentation] Development and Analysis of Novel Intravascular Large B-Cell Lymphoma NOD/Shi-Scid IL2R γnull Mouse Xenograft Model.
- Author(s)
  Kazuyuki Shimada, Satoko Shimada, Keiki Sugimoto, Fumihiko Hayakawa, Miyuki Katayama, Akihiro Hirakawa, Yusuke Takagi, Shigeo Nakamura, Masao Seto, Tomoki Naoe, Akihiro Tomita, Hitoshi Kiyoi
- Organizer
  第56回米国血液学会
- Place of Presentation
  Moscone Center （サンフランシスコ、米国）
- Year and Date
  2014-12-06 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-25293218

1. NAOE Tomoki (50217634)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
2. SHIMADA Kazuyuki (50631503)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
3. TOMITA Akihiro (80378215)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
4. KIYOI Hitoshi (90314004)

# of Collaborated Projects: 1 results

# of Collaborated Products: 22 results
5. AKAO Yukihiro (00222505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 安田貴彦 (20723977)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. KATSUMI Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
8. 能浦三奈

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 上野敏秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 松下正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 鈴木伸明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 鍬塚八千代

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 鈴木元

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 村手隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Fumihiko Hayakawa 早川 文彦

FUMIHIKO Hayakawa 早川 文彦

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日本人に特徴的な白血病原性融合遺伝子の白血病発症機構の解明Principal Investigator

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Development of a new treatment of leukemia with the induction of the differentiation-initiating isoform of MEF2D by splicing manipulationPrincipal Investigator

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Investigation of molecular mechanism of new recurrent fusion genes in ALLPrincipal Investigator

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Screening of therapeutic agent for Ph-positive ALL using patient-derived xenograft cellsPrincipal Investigator

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形質細胞分化運命決定におけるMAPKシグナルの役割とその破綻によるリンパ腫発症Principal Investigator

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Translational research toward drug discovery of leukemia

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Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cells

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Mechanism of action of a novel STAT3 inhibitor and its effect on leukemic stem cellPrincipal Investigator

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Elucidation of the mechanism of PML NB foromation.Principal Investigator

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白血病関連遺伝子産物のPMLアセチル化の意義Principal Investigator

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[Book] 血液疾患最新の治療 2017-20192017

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[Book] 急性リンパ性白血病（ALL）の基礎と臨床2016

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[Book] 専門医のための薬物療法Q&A2011

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Fumihiko Hayakawa 早川文彦

FUMIHIKO Hayakawa 早川文彦

[Book] 血液疾患最新の治療　2017-20192017

[Journal Article] 造血器腫瘍の現在と未来　AYA世代急性リンパ性白血病2023

[Journal Article] 【急性白血病-最新の診断と治療-】急性白血病の分子病態　AYA世代急性白血病の分子病態.2020