Aikata Hiroshi 相方浩

Researcher Number	30403512
Affiliation (based on the past Project Information) *help	2022 – 2023: 広島大学, 医系科学研究科(医), 専門研究員 2019 – 2021: 広島大学, 医系科学研究科(医), 准教授 2017 – 2019: 広島大学, 病院(医), 講師
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Basic Section 53010:Gastroenterology-related / Medium-sized Section 53:Organ-based internal medicine and related fields
Keywords	Principal Investigator 糖尿病 / 生活習慣病 / 肝癌 / 非ウイルス性 / 非B型非C型 Except Principal Investigator がんゲノム / 腫瘍免疫 / ゲノム / 肝胆膵がん / 空間的RNA解析 … More / ゲノム不安定 / シークエンス解析 / 膵がん / 胆道がん / 空間的発現解析 / 肝臓がん / 肝生検標本 / 脂肪蓄積 / Pin1 / NASH / 多層オミックス / ゲノム解析 / プロテオーム / ＲＮＡ / 免疫 / 分子標的治療 / 分子分類 / オミックス解析 Less

NASHの炎症、線維化におけるPin1の役割解明と臨床応用への展開
- Principal Investigator
  
  神名麻智
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo University of Science, Yamaguchi
  Hiroshima University
Genomic instability and immunology of hepato-biliary cancer
- Principal Investigator
  
  中川英刀
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Institute of Physical and Chemical Research
Elucidation of the mechanism of diabetes-related liver carcinogenesis through multilayer omics analysis focusing on abnormal glycolipid metabolismPrincipal Investigator
- Principal Investigator
  
  AIKATA HIROSHI
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hiroshima University
Multi-omics analysis for hepato-biliary-pancreatic cancers
- Principal Investigator
  
  Nakagawa Hidewaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Institute of Physical and Chemical Research
Biomarker for hepatocarcinogenesis in diabetic patientsPrincipal Investigator
- Principal Investigator
  
  Aikata Hiroshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hiroshima University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Association of hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI imaging with immune microenvironment and response to atezolizumab plus bevacizumab treatment.2023
- Author(s)
  Tamura Y, Ono A, Nakahara H, Hayes N, Fujii Y, Zhang P, Yamauchi M, Uchikawa S, Kodama K, Teraoka Y, Fujimo H, Nakahara T, Murakami E, Serikawa M, Miki D, Kawaoka T, Okamoto W, Imamura M, Nakamura Y, Awai T, Ohdan H, Fujita M, Nakagawa H, Chayama K, Aikata H, and Oka S
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 17 Pages: 4234-4234
- DOI
  10.3390/cancers15174234
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24324
[Journal Article] Impact and usefulness of the transition to the new MAFLD classification for non-B, non-C HCC: a retrospective cohort study2023
- Author(s)
  Johira Y, Nakahara T, Kinami T, Yamasaki S, Kosaka M, Shirane Y, Miura R, Murakami S, Yano S, Amioka K, Naruto K, Ando Y, Kosaka Y, Kodama K, Uchikawa S, Fujino H, Ono A, Murakami E, Okamoto W, Yamauchi M, Kawaoka T, Hayes CN, Tsuge M, Imamura M, Aikata H, Oka S
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 23 Issue: 1
- DOI
  10.1186/s12876-023-02851-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07896
[Journal Article] The presence of vessels encapsulating tumor clusters is associated with an immunosuppressive tumor microenvironment in hepatocellular carcinoma.2022
- Author(s)
  Zhang P, Ono A, Fujii Y, Hayes CN, Tamura Y, Miura R, Shirane Y, Nakahara H, Yamauchi M, Uchikawa S, Uchida T, Teraoka Y, Fujino H, Nakahara T, Murakami E, Miki D, Kawaoka T, Okamoto W, Makokha GN, Imamura M, Arihiro K, Kobayashi T, Ohdan H, Fujita M, Nakagawa H, Chayama K, and Aikata H.
- Journal Title
  
  Int J Cancer.
  
  Volume: 151 Issue: 12 Pages: 2278-2290
- DOI
  10.1002/ijc.34247
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24324
[Journal Article] Proteo-genomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets2022
- Author(s)
  Fujita Masashi、Chen Mei-Ju May、Siwak Doris Rieko、Sasagawa Shota、Oosawa-Tatsuguchi Ayako、Arihiro Koji、Ono Atsushi、Miura Ryoichi、Maejima Kazuhiro、Aikata Hiroshi、Ueno Masaki、Hayami Shinya、Yamaue Hiroki、Chayama Kazuaki、Lee Ju-Seog、Lu Yiling、Mills Gordon B.、Liang Han、Nishizuka Satoshi S.、Nakagawa Hidewaki
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 6481-6481
- DOI
  10.1038/s41467-022-34249-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19694, KAKENHI-PROJECT-21H04833, KAKENHI-PROJECT-23K24324
[Journal Article] Comprehensive analysis of full-length transcripts reveals novel splicing abnormalities and oncogenic transcripts in liver cancer2022
- Author(s)
  Kiyose Hiroki、Nakagawa Hidewaki、Ono Atsushi、Aikata Hiroshi、Ueno Masaki、Hayami Shinya、Yamaue Hiroki、Chayama Kazuaki、Shimada Mihoko、Wong Jing Hao、Fujimoto Akihiro
- Journal Title
  
  PLOS Genetics
  
  Volume: 18 Issue: 8 Pages: e1010342-e1010342
- DOI
  10.1371/journal.pgen.1010342
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04833, KAKENHI-PROJECT-23K24324
[Journal Article] Hepatic Arterial Infusion Chemotherapy Combined with Radiation Therapy for Advanced Hepatocellular Carcinoma with Tumor Thrombosis of the Main Trunk or Bilobar of the Portal Vein.2021
- Author(s)
  Kosaka Y, Kimura T, Kawaoka T, Ogawa Y, Amioka K, Naruto K, Yoshikawa Y, Kikukawa C, Suehiro Y, Yamaoka K, Ando Y, Uchikawa S, Morio K, Nakahara T, Murakami E, Takahashi S, Tsuge M, Hiramatsu A, Imamura M, Chosa K, Awai K, Nagata Y, Chayama K, Aikata H.
- Journal Title
  
  Liver Cancer
  
  Volume: 10 Issue: 2 Pages: 151-160
- DOI
  10.1159/000513706
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07896
[Journal Article] Increasing incidence of non-HBV- and non-HCV-related hepatocellular carcinoma: single-institution 20-year study.2021
- Author(s)
  Nagaoki Y, Hyogo H, Ando Y, Kosaka Y, Uchikawa S, Nishida Y, Teraoka Y, Morio K, Fujino H, Ono A, Nakahara T, Murakami E, Yamauchi M, Okamoto W, Kawaoka T, Tsuge M, Hiramatsu A, Miki D, Imamura M, Takahashi S, Chayama K, Aikata H.
- Journal Title
  
  BMC Gastroenterol.
  
  Volume: 21(1) Issue: 1 Pages: 306-306
- DOI
  10.1186/s12876-021-01884-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08288, KAKENHI-PROJECT-21K07896, KAKENHI-PROJECT-21K08006
[Journal Article] Incidence of microsatellite instability-high hepatocellular carcinoma among Japanese patients and response to pembrolizumab.2020
- Author(s)
  Kawaoka T, Ando Y, Yamauchi M, Suehiro Y, Yamaoka K, Kosaka Y, Fuji Y, Uchikawa S, Morio K, Fujino H, Nakahara T, Ono A, Murakami E, Takahashi S, Tsuge M, Hiramatsu A, Imamura M, Chayama K, Aikata H.
- Journal Title
  
  Hepatol Res.
  
  Volume: - Issue: 7 Pages: 885-888
- DOI
  10.1111/hepr.13496
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09426
[Journal Article] Tumor fibroblast growth factor receptor 4 level predicts the efficacy of Lenvatinib in patients with advanced hepatocellular carcinoma.2020
- Author(s)
  Yamauchi M, Ono A, Ishikawa A, Kodama K, Uchikawa S, Hatooka H, Zhang P, Teraoka Y, Morio K, Fujino H, Nakahara T, Murakami E, Miki D, Kawaoka T, Tsuge M, Hiramatsu A, Imanura M, Hayes CN, Fujita M, Nakagawa H, Yusui W, Aikata H, and Chayama K.
- Journal Title
  
  Clin Transl Gastroenterology
  
  Volume: 11 Issue: 5 Pages: e00179-e00179
- DOI
  10.14309/ctg.0000000000000179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H04049, KAKENHI-PROJECT-19K09206
[Journal Article] Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection.2020
- Author(s)
  Cheng X, Uchida T, Xia Y, Umarova R, Liu CJ, Chen PJ, Gaggar A, Suri V, Mucke MM, Vermehren J, Zeuzem S, Teraoka Y, Osawa M, Aikata H, Tsuji K, Mori N, Hige S, Karino Y, Imamura M, Chayama K, Liang TJ.
- Journal Title
  
  J Clin Invest.
  
  Volume: - Issue: 6 Pages: 3205-3220
- DOI
  10.1172/jci135616
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09426, KAKENHI-PROJECT-17K09427
[Journal Article] Classification of primary liver cancer with immunosuppression mechanisms and correlation with genomic alterations.2020
- Author(s)
  Fujita M, Yamaguchi R, Hasegawa T, Shimada S, Arihiro K, Hayashi S, Maejima K, Nakano K, Fujimoto A, Ono A, Aikata H, Ueno M, Hayami S, Tanaka H, Miyano S, Yamaue H, Chayama K, Kakimi K, Tanaka S, Imoto S, Nakagawa H.
- Journal Title
  
  EBioMedicine
  
  Volume: 53 Pages: 102659-102659
- DOI
  10.1016/j.ebiom.2020.102659
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10675, KAKENHI-PROJECT-18K19426, KAKENHI-PROJECT-18H04049, KAKENHI-PROJECT-19H01055, KAKENHI-PROJECT-18H02680, KAKENHI-PROJECT-18H02696, KAKENHI-PROJECT-18H03328, KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09426, KAKENHI-PROJECT-18K19575, KAKENHI-PLANNED-18H05511, KAKENHI-PROJECT-19K09206
[Journal Article] Risk factors for exacerbation of gastroesophageal varices and portosystemic encephalopathy during treatment with nucleos(t)ide analogs for hepatitis B virus-related cirrhosis.2018
- Author(s)
  Nagaoki Y, Aikata H, Daijyo K, Teraoka Y, Honda F, Nakamura Y, Hatooka M, Morio K, Fujino H, Nakahara T, Kawaoka T, Miki D, Tsuge M, Hiramatsu A, Imamura M, Kawakami Y, Ochi H, Chayama K.
- Journal Title
  
  Hepatol Res
  
  Volume: 48 Issue: 4 Pages: 264-274
- DOI
  10.1111/hepr.12996
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09426
[Journal Article] Clinical outcomes of sorafenib treatment failure for advanced hepatocellular carcinoma and candidates for regorafenib treatment in real-world practice.2018
- Author(s)
  Uchikawa S, Kawaoka T, Aikata H, Kodama K, Nishida Y, Inagaki Y, Hatooka M, Morio K, Nakahara T, Murakami E, Hiramatsu A, Tsuge M, Imamura M, Kawakami Y, Chayama K.
- Journal Title
  
  Hepatol Res.
  
  Volume: 48 Issue: 10 Pages: 814-820
- DOI
  10.1111/hepr.13180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09426
[Journal Article] Comparison of clinical outcome of hepatic arterial infusion chemotherapy and sorafenib for advanced hepatocellular carcinoma according to macrovascular invasion and transcatheter arterial chemoembolization refractory status.2018
- Author(s)
  Kodama K, Kawaoka T, Aikata H, Uchikawa S, Inagaki Y, Hatooka M, Morio K, Nakahara T, Murakami E, Tsuge M, Hiramatsu A, Imamura M, Kawakami Y, Masaki K, Honda Y, Mori N, Takaki S, Tsuji K, Kohno H, Kohno H, Moriya T, Nonaka M, Hyogo H, Aisaka Y, Chayama K.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: 33 Issue: 10 Pages: 1780-1786
- DOI
  10.1111/jgh.14152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09426
[Journal Article] Hepatic arterial infusion chemotherapy followed by sorafenib in patients with advanced hepatocellular carcinoma (HICS 55): an open label, non-comparative, phase II trial.2018
- Author(s)
  Hatooka M, Kawaoka T, Aikata H, Inagaki Y, Morio K, Nakahara T, Murakami E, Tsuge M, Hiramatsu A, Imamura M, Kawakami Y, Awai K, Masaki K, Waki K, Kohno H, Kohno H, Moriya T, Nagaoki Y, Tamura T, Amano H, Katamura Y, Chayama K.
- Journal Title
  
  BMC Cancer.
  
  Volume: 18 Issue: 1 Pages: 633-633
- DOI
  10.1186/s12885-018-4519-y
- NAID
  120006559420
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09426
[Journal Article] Comparison of hepatic arterial infusion chemotherapy between 5-fluorouracil-based continuous infusion chemotherapy and low-dose cisplatin monotherapy for advanced hepatocellular carcinoma.2018
- Author(s)
  Kawaoka T, Aikata H, Kobayashi T, Uchikawa S, Ohya K, Kodama K, Nishida Y, Daijo K, Osawa M, Teraoka Y, Inagaki Y, Honda F, Hatooka M, Morio K, Morio R, Fujino H, Nakahara T, Murakami E, Tsuge M, Hiramatsu A, Imamura M, Kawakami Y, Baba Y, Awai K, Chayama K.
- Journal Title
  
  Hepatol Res.
  
  Volume: 48 Issue: 13 Pages: 1118-1130
- DOI
  10.1111/hepr.13232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09426
[Journal Article] Comparison of Outcome of Hepatic Arterial Infusion Chemotherapy Combined with Radiotherapy and Sorafenib for Advanced Hepatocellular Carcinoma Patients with Major Portal Vein Tumor Thrombosis.2018
- Author(s)
  Kodama K, Kawaoka T, Aikata H, Uchikawa S, Nishida Y, Inagaki Y, Hatooka M, Morio K, Nakahara T, Murakami E, Tsuge M, Hiramatsu A, Imamura M, Kawakami Y, Masaki K, Honda Y, Mori N, Takaki S, Tsuji K, Kohno H, Kohno H, Moriya T, Nonaka M, Hyogo H, Aisaka Y, Kimura T, Nagata Y, Chayama K.
- Journal Title
  
  Oncology
  
  Volume: 94 Issue: 4 Pages: 215-222
- DOI
  10.1159/000486483
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09426
[Presentation] NBNC-HCCにおけるMetabolic-associated fatty liver disease（MAFLD）とNAFLDの比較検討2022
- Author(s)
  上片祐輔、中原隆志、相方浩
- Organizer
  第108回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K07896
[Presentation] 非B非C型肝細胞癌における臨床的特徴とスクリーニングにおけるFIB4-indexの可能性について2021
- Author(s)
  長沖祐子、相方　浩
- Organizer
  第57回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-21K07896
[Presentation] 非B非C型肝細胞癌の背景因子と予後に関する検討2019
- Author(s)
  長沖祐子，相方浩，茶山一彰
- Organizer
  第55回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-17K09426
[Presentation] 非B非C型慢性肝疾患患者のアルコール摂取量で群別化した比較検討2018
- Author(s)
  村上英介，相方浩，茶山一彰
- Organizer
  第104回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-17K09426
[Presentation] 2型糖尿病を合併する非B非C肝癌の臨床的特徴の解析2018
- Author(s)
  村上英介，相方浩，茶山一彰
- Organizer
  JDDW2018
- Data Source
  KAKENHI-PROJECT-17K09426
[Presentation] 非B非C型肝細胞癌の背景因子と予後に関する検討2018
- Author(s)
  長沖祐子、相方浩、茶山一彰
- Organizer
  第54回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-17K09426
[Presentation] 非B非C型肝細胞癌の背景因子と予後に関する検討2018
- Author(s)
  長沖祐子，相方浩，茶山一彰
- Organizer
  第54回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-17K09426
[Presentation] 非B非C型肝細胞癌の背景因子とリスク因子に関する検討2018
- Author(s)
  長沖祐子，相方浩，茶山一彰
- Organizer
  第54回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K09426

1. Nakagawa Hidewaki (50361621)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. 中村透 (70645796)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 井元清哉 (10345027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 山上裕機 (20191190)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 二階堂愛 (00383290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 神名麻智 (10619365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 山本屋武 (50760013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 浅野知一郎 (70242063)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 大野敦司 (80774645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. ABE Hiromi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. UENO Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 茶山一彰

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 速水晋也

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 三木大樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Aikata Hiroshi 相方 浩

Research Projects

Research Products

Co-Researchers

NASHの炎症、線維化におけるPin1の役割解明と臨床応用への展開

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Genomic instability and immunology of hepato-biliary cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of diabetes-related liver carcinogenesis through multilayer omics analysis focusing on abnormal glycolipid metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Multi-omics analysis for hepato-biliary-pancreatic cancers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Biomarker for hepatocarcinogenesis in diabetic patientsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Association of hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI imaging with immune microenvironment and response to atezolizumab plus bevacizumab treatment.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact and usefulness of the transition to the new MAFLD classification for non-B, non-C HCC: a retrospective cohort study2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The presence of vessels encapsulating tumor clusters is associated with an immunosuppressive tumor microenvironment in hepatocellular carcinoma.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Proteo-genomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comprehensive analysis of full-length transcripts reveals novel splicing abnormalities and oncogenic transcripts in liver cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hepatic Arterial Infusion Chemotherapy Combined with Radiation Therapy for Advanced Hepatocellular Carcinoma with Tumor Thrombosis of the Main Trunk or Bilobar of the Portal Vein.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increasing incidence of non-HBV- and non-HCV-related hepatocellular carcinoma: single-institution 20-year study.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Incidence of microsatellite instability-high hepatocellular carcinoma among Japanese patients and response to pembrolizumab.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor fibroblast growth factor receptor 4 level predicts the efficacy of Lenvatinib in patients with advanced hepatocellular carcinoma.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection.2020

Aikata Hiroshi 相方浩