KUBOTA Eiji 久保田英嗣

… Alternative Names

久保田英嗣クボタエイジ

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Researcher Number	30405188
Other IDs
Affiliation (Current)	2025: 名古屋市立大学, 医薬学総合研究院(医学), 准教授
Affiliation (based on the past Project Information) *help	2025: 名古屋市立大学, 医薬学総合研究院(医学), 准教授 2019 – 2023: 名古屋市立大学, 医薬学総合研究院(医学), 准教授 2018: 名古屋市立大学, 大学院医学研究科, 准教授 2016 – 2018: 名古屋市立大学, 大学院医学研究科, 講師 2015: 名古屋市立大学, 医学(系)研究科(研究院), 講師 … More 2013 – 2015: 名古屋市立大学, 医学(系)研究科(研究院), 助教 2012: 名古屋市立大学, 医学(系)研究科(研究院), 研究員 2010 – 2012: 名古屋市立大学, 大学院・医学研究科, 研究員 2008 – 2009: Nagoya City University, 大学院・医学研究科, 臨床研究医 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology / Respiratory organ internal medicine
Keywords	Principal Investigator 大腸がん / SGLT-2 / グルコース輸送体 / 大腸癌 / ATM / 消化器癌 / 胃癌 / ERas / ES細胞 / 遺伝子 … More / 癌 / 免疫細胞 / 癌微小環境 / 癌免疫 / グルコース輸送隊 / がん代謝 / SGLT2阻害剤 / 腫瘍免疫療法 / ATR / 消化管癌 / DNA修復機構 / PARP阻害剤 / 転移 / 上皮間葉移行 / Rapamycin / CPT-11 / 肝転移 / 新規治療 / Eras … More Except Principal Investigator reovirus / 腫瘍溶解性ウイルス / 遺伝子変異 / 小腸腺癌 / 非乳頭部十二指腸腺癌 / DNAミスマッチ修復遺伝子 / 十二指腸腺癌 / 小腸癌 / 十二指腸癌 / 十二指腸腺腫 / 十二指腸腫瘍 / Drug delivery system / GIST / DDS / exosome / Reovirus / がん免疫療法 / 消化管がん / 免疫療法 / STING / 大腸がん / レオウイルス / 消化管腫瘍 / 下部消化管学（小腸、大腸） / 個別化治療 / 腫瘍関連マクロファージ / 大腸癌 / CUL３ / PD-L1 / CUL3 / BTB蛋白 / 胃がん / Cullin-3 / ユビキチン / PD-L1/PD-1 / Cullin3 / 胃癌 / 神経原生炎症 / サブスタンスP / サブスタンスＰ / TRPV1 / 神経原性炎症 / 胃食道逆流症 / 慢性咳嗽 Less

腸内細菌叢を標的とした消化器がんに対するウイルス療法の最適化と個別化治療への応用Principal Investigator
- Principal Investigator
  
  久保田英嗣
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Nagoya City University
GIST治療に向けた間葉系幹細胞を用いた腫瘍溶解性ウイルスの輸送システムの開発
- Principal Investigator
  
  森義徳
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Nagoya City University
グルコース輸送体を標的とした新規オミクス解析による大腸癌の腫瘍免疫制御機構の解明Principal Investigator
- Principal Investigator
  
  久保田英嗣
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Nagoya City University
非乳頭部十二指腸腺癌の2つの発癌経路の検証と分子機構の解明
- Principal Investigator
  
  澤田武
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kanazawa University
  Nagoya City University
Expression of glucose transporter in colorectal cancer and of its usefulness as a therapeutic targetPrincipal Investigator
- Principal Investigator
  
  Kubota Eiji
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Nagoya City University
Development of novel immunotherapy for gastrointestinal cancer using oncolytic virus
- Principal Investigator
  
  Mori Yoshinori
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Nagoya City University
Membrane trafficking system of PD-L1 in gastric cancer cells and its application to immunotherapy
- Principal Investigator
  
  Joh Takashi
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya City University
Expression analysis of tumor-associated macrophages and application of treatment for colorectal cancer
- Principal Investigator
  
  Inagaki Satoko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa University
The utility of cancer therapy targeting DNA damage repair system against gastrointestinal cancerPrincipal Investigator
- Principal Investigator
  
  KUBOTA EIJI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya City University
Gastroesophageal reflux (GER)-associated cough: Effect of treatment on cellular and neurogenic inflammation
- Principal Investigator
  
  takemura masaya
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nagoya City University
The efficacy of PARP inhibitor against gastrointestinal cancerPrincipal Investigator
- Principal Investigator
  
  Kubota Eiji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya City University
The significance of ES cell expressed Ras, ERas as a novel target for gastric cancer treatmentPrincipal Investigator
- Principal Investigator
  
  KUBOTA Eiji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya City University
胃癌の新規診断,化学療法を目指したES細胞特異的Ras,Erasの機能解析Principal Investigator
- Principal Investigator
  
  久保田英嗣
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya City University

All 2020 2017 2016 2015 2014 2011 2010 2008 Other

All Journal Article Presentation

[Journal Article] Significance of gene mutations in the Wnt signaling pathway in traditional serrated adenomas of the colon and rectum2020
- Author(s)
  Nakanishi, H. Sawada, T. Kaizaki, Y. Ota, R. Suzuki, H. Yamamoto, E. Aoki, H. Eizuka, M. Hasatani, K. Takahashi, N. Inagaki, S. Ebi, M. Kato, H. Kubota, E. Kataoka, H. Takahashi, S. Tokino, T. Minamoto, T. Sugai, T. Sasaki, Y.
- Journal Title
  
  PLoS One
  
  Volume: 15 Issue: 2 Pages: e0229262-e0229262
- DOI
  10.1371/journal.pone.0229262
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-19H03518, KAKENHI-PROJECT-17K08700, KAKENHI-PROJECT-17K09374, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-20K07412, KAKENHI-PROJECT-20K16225, KAKENHI-PROJECT-18K07949, KAKENHI-PROJECT-18K19577, KAKENHI-PROJECT-19H03727
[Journal Article] Neddylated Cullin 3 is required for vascular endothelial-cadherin-mediated endothelial barrier function.2017
- Author(s)
  Sakaue T, Fujisaki A, Nakayama H, Maekawa M, Hiyoshi H, Kubota E, Joh T, Izutani H, Higashiyama S.
- Journal Title
  
  Cancer Sci.
  
  Volume: 108 Issue: 2 Pages: 208-215
- DOI
  10.1111/cas.13133
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H04698, KAKENHI-PROJECT-15K18858, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-16K19038, KAKENHI-PROJECT-17K09357
[Journal Article] The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells2017
- Author(s)
  Sakaue T, Sakakibara I, Fujisaki A, Uesugi T, Nakashiro K, Hamakawa H, Kubota E, Joh T, Imai Y, Izutani H, Higashiyama S.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 42845-42845
- DOI
  10.1038/srep42845
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04961, KAKENHI-PROJECT-16H04698, KAKENHI-PROJECT-15K15552, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-17K09357
[Journal Article] Cullin-3 and its adaptor protein ANKFY1 determine the surface level of integrin beta1 in endothelial cells.2017
- Author(s)
  Maekawa M, Tanigawa K, Sakaue T, Hiyoshi H, Kubota E, Joh T, Watanabe Y, Taguchi T, Higashiyama S
- Journal Title
  
  Biolology Open
  
  Volume: 6 Pages: 1707-1719
- DOI
  10.1242/bio.029579
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09357, KAKENHI-PROJECT-16H04698, KAKENHI-PROJECT-15K18858, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-16K19038
[Journal Article] Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines2014
- Author(s)
  Kubota E, Williamson CT, Elegbede A, Ruiqiong Y, Peterson L, Bebb DG, Lees-Miller SP
- Journal Title
  
  Cell cycle
  
  Volume: 13 Issue: 13 Pages: 2129-2137
- DOI
  10.4161/cc.29212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460930
[Journal Article] ERas enhances resistance to CPT-11 in gastric cancer2011
- Author(s)
  Kubota E, Kataoka H, et al
- Journal Title
  
  Anticancer Res
  
  Volume: 31(10) Pages: 3353-3360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590688
[Journal Article] ERas Enhances Resistance to CPT-11 in Gastric Cancer2011
- Author(s)
  Kubota E, Kataoka H, Tanaka M, Okamoto Y, Ebi M, Hirata Y, Murakami K, Mizoshita T, Shimura T, Mori Y, Tanida S, Kamiya T, Aoyama M, Asai K, Joh T
- Journal Title
  
  Anticancer Res
  
  Volume: 10 Pages: 3353-60
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/21965746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590688
[Journal Article] Role of ES Cell-Expressed Ras (ERas) in Tumorigenicity of Gastric Cancer.2010
- Author(s)
  Kubota E, Kataoka H, Aoyama M, Mizoshita T, Mori Y, Shimura T, Tanaka M, Sasaki M, Takahashi S, Asai K, Joh T
- Journal Title
  
  Am J Pathol
  
  Volume: 177 Issue: 2 Pages: 955-963
- DOI
  10.2353/ajpath.2010.091056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590688, KAKENHI-PROJECT-22591165
[Journal Article] Resistance to chemotherapeutic agents and promotion of transforming activity mediated by embryonic stem cell-expressed Ras (ERas) signal in neuroblastoma cells2010
- Author(s)
  Aoyama M, Kataoka H, Kubota E, Tada T, Asai K.
- Journal Title
  
  Int J Oncol
  
  Volume: 37 Pages: 1011-6
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/20811723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590688
[Journal Article] Role of ES cell-expressed Ras, ERas in Tumorigenicity of Gastric Cancer2010
- Author(s)
  Eiji Kubota
- Journal Title
  
  American Journal of Pathology
  
  Volume: 177(2) Pages: 955-963
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590688
[Presentation] 胃食道逆流症による慢性咳嗽における神経ペプチドの関与2017
- Author(s)
  武田典久　竹村昌也　福光研介　浅野貴光　市川博也　金光禎寛　久保田英嗣　神谷武　新実彰男
- Organizer
  第57回日本呼吸器学会学術講演会
- Place of Presentation
  東京国際フォーラム（東京都　千代田区）
- Data Source
  KAKENHI-PROJECT-26461165
[Presentation] Treatment of gastroesophageal reflux disease (GERD) makes improvement of cough symptom - association with substance P in the airway.2017
- Author(s)
  Norihisa Takeda, Masaya Takemura, Kensuke Fukumitsu, Takamitsu Asano, Hiroya Ichikawa, Yoshihiro Kanemitsu, Eiji Kubota, Takeshi Kamiya, Akio Niimi
- Organizer
  American Thoracic Society
- Place of Presentation
  Washingtong DC (USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461165
[Presentation] 2.胃食道逆流症（GERD）による慢性咳嗽における神経ペプチドの関与2017
- Author(s)
  武田典久, 竹村昌也, 福光研介, 浅野貴光市川博也, 金光禎寛, 久保田英嗣, 神谷武, 新実彰男
- Organizer
  第57回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-26461165
[Presentation] Improvement of cough symptom after treatment of gastroesophageal reflux disease2017
- Author(s)
  Takeda N, Takemura M, Hijikata　H, Fukumitsu K, Ichikawa H,　Asano T, Kanemitsu, Y, Uemura T, Takakuwa O, Ohkubo H, Maeno K, Ito Y, Oguri T, Nakamura A ,Kubota E, Niimi A.
- Organizer
  American Thoracic Society International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461165
[Presentation] ATMをバイオマーカーとした胃癌に対するPARP阻害剤の有効性の検討2016
- Author(s)
  久保田英嗣　片岡洋望　城卓志
- Organizer
  第102回日本消化器病学会総会
- Place of Presentation
  京王プラザホテル（東京都・新宿区）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-16K09287
[Presentation] ATMをバイオマーカーとした胃癌に対するPARP阻害剤の有効性の検討2015
- Author(s)
  久保田英嗣
- Organizer
  第１０２回　日本消化器病学会総会
- Place of Presentation
  京王プラザホテル（東京、新宿）
- Year and Date
  2015-04-21
- Data Source
  KAKENHI-PROJECT-25460930
[Presentation] (English Oral Session E4-3 Ras-related gene) (E1052) ES cell-specific Ras, ERas accelerates liver metastases of gastric cancer through epithelial-mesenchymal transition2011
- Author(s)
  片岡洋望, 久保田英嗣, 他
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場,名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22590688
[Presentation] (パネルディスカッション21:消化器癌の悪性度・予後における分子診断)(PD21-4)胃癌の悪性度におけるES細胞特異的Ras, ERas遺伝子発現の意義2011
- Author(s)
  片岡洋望, 久保田英嗣, 他
- Organizer
  第19回日本消化器関連学会週間
- Place of Presentation
  福岡国際会議場,福岡
- Year and Date
  2011-10-23
- Data Source
  KAKENHI-PROJECT-22590688
[Presentation] 胃癌の肝転移におけるES細胞特異的Ras, ERasの役割2010
- Author(s)
  久保田英嗣
- Organizer
  胃癌学会
- Place of Presentation
  朱鷺メッセ新潟コンベンションセンター(新潟県)
- Year and Date
  2010-03-04
- Data Source
  KAKENHI-PROJECT-20659117
[Presentation] Role of ES cell-expressed Ras, ERas in Gastric Cancer2010
- Author(s)
  久保田英嗣
- Organizer
  2010 Cancer Research Conference
- Place of Presentation
  カナダ
- Year and Date
  2010-11-08
- Data Source
  KAKENHI-PROJECT-22590688
[Presentation] Novel ERas plays crucial role for epithelial to mesenchymal transition and liver metastases in human gastric cancer2008
- Author(s)
  久保田英嗣
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-20659117
[Presentation] ES cell specific Ras, ERas in gastric cancer accelerates its liver metastasis2008
- Author(s)
  久保田英嗣
- Organizer
  米国消化器学会
- Place of Presentation
  San Diego (米国)
- Year and Date
  2008-05-18
- Data Source
  KAKENHI-PROJECT-20659117
[Presentation] 胃癌肝転移におけるES細胞特異的Ras, ERas遺伝子発現の意義2008
- Author(s)
  久保田英嗣
- Organizer
  第50回日本消化器病学会大会
- Place of Presentation
  東京
- Year and Date
  2008-10-03
- Data Source
  KAKENHI-PROJECT-20659117
[Presentation] ROLE OF NOVEL ES CELL-EXPRESSED RAS, ERAS IN GASTRIC CANCER2008
- Author(s)
  久保田英嗣
- Organizer
  第16回欧州消化器病週間
- Place of Presentation
  Vienna (オーストリア)
- Year and Date
  2008-10-21
- Data Source
  KAKENHI-PROJECT-20659117
[Presentation] 胃癌におけるATM, p53発現と新規分子標的薬PARP阻害剤感受性
- Author(s)
  久保田英嗣、片岡洋望、城卓志
- Organizer
  第73回日本癌学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25460930
[Presentation] 胃癌に対するPARP阻害剤の効果
- Author(s)
  久保田英嗣、片岡洋望、城卓志
- Organizer
  第25回消化器癌発生学会総会/第8回国際消化器癌発生会議
- Place of Presentation
  ホテル日航福岡（福岡県・福岡市）
- Year and Date
  2014-11-14 – 2014-11-15
- Data Source
  KAKENHI-PROJECT-25460930
[Presentation] ATM and p53 expression level correlate with sensitivity to olaparib in gastric cancer.
- Author(s)
  Eiji Kubota
- Organizer
  Digestive Disease Week 2014
- Place of Presentation
  mcCormic Place, Chicago, Illinois
- Data Source
  KAKENHI-PROJECT-25460930

1. KATAOKA Hiromi (40381785)

# of Collaborated Projects: 8 results

# of Collaborated Products: 9 results
2. ASAI Kiyofumi (70212462)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. AOYAMA Mineyoshi (70363918)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. Mori Yoshinori (80468248)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 澤田武 (60345626)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 八木崇志 (00781840)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SUZUKI Syugo (60363933)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MIURA YUTAKA (90285198)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. takemura masaya (30378707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. Joh Takashi (30231369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. Inagaki Satoko (00768781)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 新實彰男 (30252513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. 東山繁樹 (60202272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. 日吉裕美 (10406530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 笠島里美 (20444200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 中村慶史 (30608691)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 佐々木泰史 (70322328)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 八尾隆史 (20243933)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. Sakaue Tomohisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. Maekawa Masashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. IMAI Yuuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 榊原伊織

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUBOTA Eiji 久保田 英嗣

久保田 英嗣 クボタ エイジ

Research Projects

Research Products

Co-Researchers

腸内細菌叢を標的とした消化器がんに対するウイルス療法の最適化と個別化治療への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

GIST治療に向けた間葉系幹細胞を用いた腫瘍溶解性ウイルスの輸送システムの開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

グルコース輸送体を標的とした新規オミクス解析による大腸癌の腫瘍免疫制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

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非乳頭部十二指腸腺癌の2つの発癌経路の検証と分子機構の解明

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Expression of glucose transporter in colorectal cancer and of its usefulness as a therapeutic targetPrincipal Investigator

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Development of novel immunotherapy for gastrointestinal cancer using oncolytic virus

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Membrane trafficking system of PD-L1 in gastric cancer cells and its application to immunotherapy

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Expression analysis of tumor-associated macrophages and application of treatment for colorectal cancer

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The utility of cancer therapy targeting DNA damage repair system against gastrointestinal cancerPrincipal Investigator

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Gastroesophageal reflux (GER)-associated cough: Effect of treatment on cellular and neurogenic inflammation

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The efficacy of PARP inhibitor against gastrointestinal cancerPrincipal Investigator

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The significance of ES cell expressed Ras, ERas as a novel target for gastric cancer treatmentPrincipal Investigator

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胃癌の新規診断,化学療法を目指したES細胞特異的Ras,Erasの機能解析Principal Investigator

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KUBOTA Eiji 久保田英嗣

久保田英嗣クボタエイジ