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mizui masayuki  水井 理之

… Alternative Names

Mizui Masayuki  水井 理之

MIZUI Masayuki  水井 理之

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Researcher Number 30423106
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-2543-8108
Affiliation (Current) 2025: 大阪大学, 大学院医学系研究科, 准教授
Affiliation (based on the past Project Information) *help 2023: 大阪大学, 大学院医学系研究科, 准教授
2022 – 2023: 大阪大学, 大学院医学系研究科, 講師
2019 – 2022: 大阪大学, 医学系研究科, 講師
2016 – 2018: 大阪大学, 医学系研究科, 助教
2015: 大阪大学, 医学(系)研究科(研究院), 助教
2007 – 2012: Osaka University, 微生物病研究所, 助教
2006: 大阪大学, 微生物病研究所, 特任研究員
Review Section/Research Field
Principal Investigator
Collagenous pathology/Allergology / Basic Section 54020:Connective tissue disease and allergy-related / Immunology / 膠原病・アレルギー・感染症内科学
Except Principal Investigator
Basic Section 53040:Nephrology-related / Medium-sized Section 53:Organ-based internal medicine and related fields / Immunology
Keywords
Principal Investigator
自己免疫 / 抗CD3抗体 / T細胞受容体 / 自己免疫疾患 / 制御性T細胞 / 炎症 / リンパ球 / 代謝調節 / 脂肪酸酸化 / グルタミン … More / Th17 / autoimmune diseases / glutaminolysis / Fatty acid / IL-17 / PPARa / 断片化抗CD3抗体 / T細胞受容体発現 / Fc不活化 / 臓器障害 / 自己抗体 / SLE / 抗CD3サイレント抗体 / 抗体 / ③自己免疫疾患 / ②抗体産生反応 / ①T細胞受容体 / regulatory T cells / antibody responses / T cell receptor / 全身性エリテマトーデス / TIM-4欠損マウス / 樹状細胞 / 樹状細細胞 / TIM-4 / 抗Tim-4抗体 / 抗Tim- 4抗体 / T細胞増殖 / 抗原提示細胞 / Tim-1 / Tim-4 / Timファミリー分子 … More
Except Principal Investigator
Single cell RNA seq / 腎予後 / 無作為化比較試験 / SGLT2阻害剤 / 腎移植 / エクソソーム解析 / シングルセルRNA-seq解析 / AI / AIによる腎病理解析 / オートファジー / D-アミノ酸 / シングルセルRNA解析 / AIによる腎病理診断 / 精密医療 / CKD / 腎発生 / single cell RNA解析 / 気道アレルギー / 分子標的 / セマフォリンファミリー / Plexin / 免疫制御 / リンパ球 / IL-4 / Th2 / Tim-2 / Sema4A / EBウイルス / B細胞抗原受容体 / PKN1 / Akt / plexin B2 / Sema4D / 樹状細胞 / B細胞 / T細胞 / アレルギー疾患 / プレキシン / セマフォリン Less
  • Research Projects

    (9 results)
  • Research Products

    (20 results)
  • Co-Researchers

    (17 People)
  •  Dapagliflozin preserves allograft function in kidney transplant recipients (KTRs).

    • Principal Investigator
      難波 倫子
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Osaka University
  •  PPARαをターゲットとしたリンパ球代謝リモデリングによる自己免疫疾患制御Principal Investigator

    • Principal Investigator
      水井 理之
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54020:Connective tissue disease and allergy-related
    • Research Institution
      Osaka University
  •  Development of a prognostic evaluation method for precision medicine of early-stage CKD patients

    • Principal Investigator
      Isaka Yoshitaka
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Osaka University
  •  Elucidation of renal disease onset and progression mechanism using single cell RNA-sequence

    • Principal Investigator
      ISAKA YOSHITAKA
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 53:Organ-based internal medicine and related fields
    • Research Institution
      Osaka University
  •  Modified anti-CD3 as a therapeutic antibody for lupusPrincipal Investigator

    • Principal Investigator
      Mizui Masayuki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      Osaka University
  •  The effect of quantitative T-cell receptor down-modulation in antibody reponses and its application for autoimnune diseasesPrincipal Investigator

    • Principal Investigator
      Mizui Masayuki
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      Osaka University
  •  樹状細胞表面分子による制御性T細胞機能調節機構の解明Principal Investigator

    • Principal Investigator
      水井 理之
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Osaka University
  •  Roles of guidance factors in immune regulation

    • Principal Investigator
      KIKUTANI Hitoshi
    • Project Period (FY)
      2008 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Immunology
    • Research Institution
      Osaka University
  •  Tim分子によるTh1/Th2反応制御機構の解明Principal Investigator

    • Principal Investigator
      水井 理之
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Osaka University

All 2024 2023 2022 2021 2020 2019 2018 2010 2009 2008 2007

All Journal Article Presentation

  • [Journal Article] Association between urinary uric acid excretion and kidney outcome in patients with CKD2024

    • Author(s)
      Asahina Yuta、Sakaguchi Yusuke、Oka Tatsufumi、Hattori Koki、Kawaoka Takayuki、Doi Yohei、Yamamoto Ryohei、Matsui Isao、Mizui Masayuki、Kaimori Jun-Ya、Isaka Yoshitaka
    • Journal Title

      Scientific Reports

      Volume: 14 Issue: 1 Pages: 5119-5119

    • DOI

      10.1038/s41598-024-55809-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02935
  • [Journal Article] Development of a three-dimensional HPLC system for the determination of serine, threonine and allo-threonine enantiomers in the plasma of patients with chronic kidney disease2024

    • Author(s)
      Oyaide Mai、Ishii Chiharu、Akita Takeyuki、Kimura Tomonori、Sakai Shinsuke、Mizui Masayuki、Mita Masashi、Ide Tomomi、Isaka Yoshitaka、Hamase Kenji
    • Journal Title

      Journal of Chromatography A

      Volume: 1719 Pages: 464739-464739

    • DOI

      10.1016/j.chroma.2024.464739

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19414, KAKENHI-PROJECT-23K14335, KAKENHI-PROJECT-23KJ1732, KAKENHI-PROJECT-22K06547, KAKENHI-PROJECT-21H02935, KAKENHI-PROJECT-23K24015
  • [Journal Article] Single cell RNA sequencing uncovers cellular developmental sequences and novel potential intercellular communications in embryonic kidney2021

    • Author(s)
      Isao Matsui, Ayumi Matsumoto, Kazunori Inoue, Yusuke Katsuma, Seiichi Yasuda, Karin Shimada, Yusuke Sakaguchi, Masayuki Mizui, Jun-Ya Kaimori, Yoshitsugu Takabatake, Yoshitaka Isaka
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 73-73

    • DOI

      10.1038/s41598-020-80154-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08725, KAKENHI-PROJECT-19K22621, KAKENHI-PROJECT-21H02935
  • [Journal Article] Natural and modified IL-2 for the treatment of cancer and autoimmune diseases2019

    • Author(s)
      Mizui M.
    • Journal Title

      Clin Immunol

      Volume: 206 Pages: 63-70

    • DOI

      10.1016/j.clim.2018.11.002

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10001
  • [Journal Article] Targeting Regulatory T Cells to Treat Patients With Systemic Lupus Erythematosus2018

    • Author(s)
      Masayuki Mizui and George C. Tsokos
    • Journal Title

      Frontiers in Immunology

      Volume: 印刷中

    • DOI

      10.3389/fimmu.2018.00786

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10001
  • [Journal Article] Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II2010

    • Author(s)
      Takamatsu H, Takegahara N, Nakagawa Y, Tomura M, Taniguchi M, Friedel RH, Rayburn H, Tessier-Lavigne M, Yoshida Y, Okuno T, Mizui M, Kang S, Nojima S, Tsujimura T, Nakatsuji Y, Katayama I, Toyofuku T, Kikutani H, Kumanogoh A
    • Journal Title

      Nat Immunol.

      Volume: 11(7) Issue: 7 Pages: 594-600

    • DOI

      10.1038/ni.1885

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20229007, KAKENHI-PROJECT-21590196
  • [Journal Article] Semaphorins guide cells into the lymphatics by activating myosin II.2010

    • Author(s)
      Takamatsu, H., N.Takegahara, Y.Nakagawa, M.Tomura, M.Taniguchi, R.H.Friedel, H.Rayburn, M.Tessier-Lavigne, Y.Yoshida, T.Okuno, M.Mizui, S.Kang, S.Nojima, T.Tsujimura, Y. Nakatsuji, I.Katayama, T.Toyofuku, H.Kikutani, A.Kumanogoh.
    • Journal Title

      Nat Immunol 11

      Pages: 594-600

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20229007
  • [Journal Article] Immune semaphorins : novel features of neural guidance molecules.2009

    • Author(s)
      Mizui, M., et al.
    • Journal Title

      J. Celin. Immunol., 29:1-11, 2009 29

      Pages: 1-11

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20229007
  • [Journal Article] Immune semaphorins: novel features of neural guidance molecules.2009

    • Author(s)
      Mizui M, Kumanogoh A, Kikutani H.
    • Journal Title

      J Clin Immunol.

      Volume: 29(1) Issue: 1 Pages: 1-11

    • DOI

      10.1007/s10875-008-9263-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20229007
  • [Journal Article] Immune semaphorins : novel features of neural guidance molecules.2009

    • Author(s)
      Mizui, M., A.Kuanogoh, H. Kikutani
    • Journal Title

      J.Clin.Immunol. 29

      Pages: 1-11

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20229007
  • [Journal Article] Bimodal regulation of T cell-mediated immune responses by TIM-42008

    • Author(s)
      Mizui, et. al.
    • Journal Title

      International Immunology in press

    • NAID

      10021241281

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790681
  • [Journal Article] Bimodal regulation of T cell-mediated immune responses by TIM-4.2008

    • Author(s)
      Mizui M, Shikina T, Arase H, Suzuki K, Yasui T, Rennert PD, Kumanogoh A, Kikutani H.
    • Journal Title

      Int Immunol.

      Volume: 20(5) Issue: 5 Pages: 695-708

    • DOI

      10.1093/intimm/dxn029

    • NAID

      10021241281

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20229007
  • [Journal Article] Bimodal regulation of T cell-mediated immune responses by TIM-4.2008

    • Author(s)
      Mizui, M., T.Shikina, H.Arase, K.Suzuki, T.Yasui, P.D.Rennert, A.Kumanogoh, H.Kikutani
    • Journal Title

      Int.Immunol. 20

      Pages: 695-708

    • NAID

      10021241281

    • Data Source
      KAKENHI-PROJECT-20229007
  • [Journal Article] Bimodal regulation of T cell-mediated immune responses by TIM-42008

    • Author(s)
      Mizui, M., et al.
    • Journal Title

      Int. Immunol., 20:695-708 20

      Pages: 695-708

    • NAID

      10021241281

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20229007
  • [Journal Article] Neuropilin-1 : the glue between regulatory T cells and dendritic cells?, 28 : 302-303, 2008.2008

    • Author(s)
      Mizui, M., H. Kikutani
    • Journal Title

      Immunity 28

      Pages: 302-303

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20229007
  • [Presentation] A selective PPARa-modulator-mediated metabolic alteration ameliorates autoimmunity through restraining glutaminolysis in Th17 cells2023

    • Author(s)
      Satoshi Masuyama, Masashi Morita, Tatsusada Okuno, Masayuki Mizui and Yoshitaka Isaka
    • Organizer
      The 2nd International Symposium of Clinical Immunology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K08562
  • [Presentation] A selective PPARa modulator-mediated metabolic manipulation ameliorates autoimmunity by limiting glutaminolysis in Th17 cells2022

    • Author(s)
      増山慧、水井理之、森田将史、奥野龍禎、猪阪善隆
    • Organizer
      日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K08562
  • [Presentation] Efficacy and safety of non-mitogenic anti-CD3 antibody administration in the treatment of lupus2020

    • Author(s)
      Masashi Morita, Masayuki Mizui, Satoshi Masuyama and Yoshitaka Isaka
    • Organizer
      European League against Rheumatism Annual Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10001
  • [Presentation] Comprehensive detection assay of physiological interaction partners for the Epstein-Barr virus latent membrane protein 1 by bimolecular fluorescence complementation system coupled with enhanced retrovirus mutagenesis.2010

    • Author(s)
      Mizui, M., T.Yasui, K.Morita, T.Morimoto, S.Tada, H.Kikutani
    • Organizer
      The 14^<th> Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases.
    • Place of Presentation
      Birmingham, UK.
    • Data Source
      KAKENHI-PROJECT-20229007
  • [Presentation] Biphasic action of Tim-4 on T cell-mediated immune responses2007

    • Author(s)
      水井 理之
    • Organizer
      第37回 日本免疫学会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-22
    • Data Source
      KAKENHI-PROJECT-18790681
  • 1.  ISAKA YOSHITAKA (00379166)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 2.  井上 和則 (10631301)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  松井 功 (60456986)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 4.  KIKUTANI Hitoshi (80161412)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 5.  YASUI Teruhito (60283074)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 6.  SAKAKIBARA Shuhei (10618838)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  山本 陵平 (00533853)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  木村 友則 (00631300)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  高畠 義嗣 (30403075)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  難波 倫子 (30734420)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  山中 和明 (10648017)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  野々村 祝夫 (30263263)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  土井 洋平 (30846382)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  今村 亮一 (40456976)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  濱野 高行 (50403077)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  阿部 豊文 (90750894)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  増山 慧 (80869917)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results

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