Tahara Hiroyuki 田原裕之

… Alternative Names

TAHARA HIROYUKI 田原裕之

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Researcher Number	30423354
Other IDs
Affiliation (Current)	2025: 広島大学, 病院(医), 助教
Affiliation (based on the past Project Information) *help	2017 – 2024: 広島大学, 病院(医), 助教 2016: 広島大学, 病院(医), 病院助教 2015: 広島大学, 大学病院, 病院助教 2013 – 2014: 広島大学, 大学病院, 医科診療医
Review Section/Research Field	Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / General surgery / Digestive surgery Except Principal Investigator Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Keywords	Principal Investigator ヒト化マウス / 慢性拒絶反応 / 抗体関連型拒絶反応 / 異種移植 / 移植免疫 / 抗体関連拒絶反応 / 拒絶反応 / 臓器移植 / HLA抗体 / 同種移植 … More / 糖鎖 / 免疫学 / トランスレーショナルリサーチ / 移植・再生医療 … More Except Principal Investigator B細胞 / 免疫回避 / 糖鎖抗原 / ネオアンチゲン / 制御性B細胞 / 癌免疫回避 / 移植免疫 / 腫瘍免疫 / 癌免疫 / 間接認識経路 / シグナル制御蛋 / 間接認識機構 / 遺伝子多型 / アロ免疫機構 / ヒトiPS細胞 / 免疫寛容 / シグナル制御 / 拒絶 / HLA適合移植 / 獲得免疫 / 自然免疫 / 免疫制御 / 拒絶反応 / SIRPα / HLA一致 / 他家細胞移植 / iPS細胞 Less

Elucidation of the mechanism of cancer immune evasion by glycan-responsive B cells and development of regulatory methods
- Principal Investigator
  
  大段秀樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Hiroshima University
Analysis of antibody-related rejection and clinical application using anti-donor-specific HLA antibody-producing humanized micePrincipal Investigator
- Principal Investigator
  
  田原裕之
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Hiroshima University
Development of therapeutic methods for controlling novel cancer immune-evasion mechanisms by non-conventional B cells
- Principal Investigator
  
  Ohdan Hideki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Hiroshima University
Elucidation of anti-donor specific HLA antibody production mechanism using a humanized mouse model and clinical application for individualized treatmentPrincipal Investigator
- Principal Investigator
  
  TAHARA HIROYUKI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Hiroshima University
Elucidation of novel rejection mechanism after HLA-matched transplantation using allogeneic iPS cells
- Principal Investigator
  
  Ohdan Hideki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Hiroshima University
Establishment of a novel regulating method for allogeneic or xenogeneic antibody-mediated rejection using a humanized mousePrincipal Investigator
- Principal Investigator
  
  TAHARA HIROYUKI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Hiroshima University
Elucidation of mechanism of antibody-related rejection bay using humanized immunodeficient mice lacking xenogeneic antigenPrincipal Investigator
- Principal Investigator
  
  TAHARA HIROYUKI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Digestive surgery
- Research Institution
  Hiroshima University

All 2023 2022 2021 2020 2019 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] ユニークな表現型を示すB細胞による癌関連ペプチド抗原に対するT細胞応答2023
- Author(s)
  井出隆太、田中友加、望月哲矢、中野亮介、坂井寛、黒田慎太郎、田原裕之、大平真裕、井手健太郎、小林剛、大段秀樹
- Journal Title
  
  日本免疫治療学会誌
  
  Volume: 11 Pages: 5-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22H00479
[Journal Article] Heterophile carbohydrate antigen N‐glycolylneuraminic acid as a potential biomarker in patients with hepatocellular carcinoma2023
- Author(s)
  Shuji Akimoto, Hiroyuki Tahara, Senichiro Yanagawa, Kentaro Ide, Yuka Tanaka, Tsuyoshi Kobayashi, Hideki Ohdan
- Journal Title
  
  Cancer Reports
  
  Volume: 6 Issue: 8
- DOI
  10.1002/cnr2.1831
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22H00479
[Journal Article] History and future prospects of HLA antibody-producing humanized mouse models2023
- Author(s)
  田原裕之、柳川泉一郎、築山尚史、大段秀樹
- Journal Title
  
  Organ Biology
  
  Volume: 30 Issue: 2 Pages: 083-087
- DOI
  10.11378/organbio.30.083
- ISSN
  1340-5152, 2188-0204
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08669
[Journal Article] Development of a humanized mouse model to analyze antibodies specific for human leukocyte antigen (HLA)2021
- Author(s)
  Yanagawa Senichiro、Tahara Hiroyuki、Shirouzu Takayuki、Kawai Shintaro、Tanaka Yuka、Ide Kentaro、Akimoto Shuji、Ohdan Hideki
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 2 Pages: e0236614-e0236614
- DOI
  10.1371/journal.pone.0236614
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08597, KAKENHI-PROJECT-21K08669
[Journal Article] 当科における異種移植研究の変遷と今後の展望2016
- Author(s)
  田原裕之
- Journal Title
  
  Organ Biology
  
  Volume: 23 Pages: 154-157
- NAID
  130005263593
- Data Source
  KAKENHI-PROJECT-15K10025
[Presentation] ドナー抗原特異的HLA抗体産生ヒト化マウスモデルによる抗体産生メカニズムの解明2023
- Author(s)
  築山尚史, 田原裕之，大段秀樹
- Organizer
  第123回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K08669
[Presentation] SNPによる免疫応答への影響解析を目的としたPrime editing法によるIL-1B SNP改変株の作成2023
- Author(s)
  箱田啓志, 田中友加, 別木智昭, 今岡洸輝, 荒田了輔, 望月哲矢, 小野紘輔, 築山尚史, 井出隆太, 中野亮介, 坂井寛, 谷峰直樹, 田原裕之, 大平真裕, 井手健太郎, 小林　剛, 大段秀樹
- Organizer
  第20回日本免疫治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22H00479
[Presentation] Effect of genetic polymorphisms of IL-1β on portal dissemination of hepatocellular carcinoma2023
- Author(s)
  難波洋介, 小林剛, 黒田慎太郎, 中野亮介, 坂井寛, 谷峰直樹, 田原裕之, 大平真裕, 井手健太郎, 大段秀樹
- Organizer
  第35回日本肝胆膵外科学会・学術集会
- Data Source
  KAKENHI-PROJECT-22H00479
[Presentation] Peritoneal cavity B cells exhibit suppressive properties in indirect pathway T cell responses2023
- Author(s)
  Tetsuya Mochizuki, Yuka Tanaka, Ryuta Ide, Ryosuke Nakano, Hiroshi Sakai, Naoki Tanimine, Hiroyuki Tahara, Masahiro Ohira, Kentaro Ide, Hideki Ohdan
- Organizer
  American Transplant Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00479
[Presentation] Elucidation of the mechanism of antibody production by HLA antigen-specific antibody-producing humanized mouse model2023
- Author(s)
  築山尚史、田中友加、中野　亮介、坂井　寛、谷峰直樹、大平真裕、田原裕之、井手健太郎、大段秀樹
- Organizer
  第78回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-21K08669
[Presentation] HLA抗原特異的抗体産生ヒト化マウスモデル作製の試み2022
- Author(s)
  築山尚史、田原裕之、大段秀樹
- Organizer
  日本異種移植研究会
- Data Source
  KAKENHI-PROJECT-21K08669
[Presentation] MyD88シグナル制御による異種糖鎖抗原反応生B細胞の新制御法2021
- Author(s)
  望月哲矢、田中友加、坂井寛、田原裕之、谷峰直樹、大平真裕、井手健太郎、大段秀樹
- Organizer
  第57回日本移植学会総会
- Data Source
  KAKENHI-PROJECT-19H01057
[Presentation] 異種糖鎖抗原NeuGc発現肝細胞癌の腫瘍学的特性における解析2021
- Author(s)
  秋本修志、田原裕之、大段秀樹
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19H01057
[Presentation] Oncological properties in hepatocellular carcinoma expressing xenogeneic carbohydrate antigen N-glycorylneuraminic acid (NeuGc) can predict early recurrence after hepatic resection2021
- Author(s)
  Tahara H, Akimoto S, Kobayashi T, Ohdan H.
- Organizer
  第33回日本肝胆膵外科学会学術集会
- Data Source
  KAKENHI-PROJECT-19H01057
[Presentation] 異種糖鎖抗原NeuGc発現肝細胞癌の腫瘍学的特性と早期再発を予測しうるバイオマーカーとしての可能性2021
- Author(s)
  秋本修志、田原裕之、田中友加、井手健太郎、小林剛、大段秀樹
- Organizer
  第76回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-19H01057
[Presentation] リンパ球混合試験を用いた免疫モニタリングの肝移植免疫抑制漸減に関するCross-sectional study2020
- Author(s)
  小野紘輔, 谷峰直樹, 築山尚史, 井出隆太, 佐藤幸毅, 山根宏明, 今岡祐輝, 秋本修志, 田原裕之, 大平真裕, 井手健太郎, 小林剛, 田中友加, 大段秀樹
- Organizer
  第56回日本移植学会総会
- Data Source
  KAKENHI-PROJECT-20K20391
[Presentation] 異種糖鎖抗原NeuGcにおける腫瘍学的特性の解析2020
- Author(s)
  秋本修志、田原裕之, 井出隆太, 築山尚史, Akhmet Seidakhmetov, 山根宏昭, 佐藤幸毅, 今岡祐輝, 本明慈彦, 中島一記, Jamilya Saparbay, 田口和浩, 田中飛鳥, Doskali Marlen, 谷峰直樹, 森本博司, 大平真裕, 井手健太郎, 小林剛,田中友加, 大段秀樹
- Organizer
  第22回異種移植研究会
- Data Source
  KAKENHI-PROJECT-19H01057
[Presentation] 肝移植におけるHLA抗体検査の意義エピトープ解析と免疫応答の関連性についての検討2020
- Author(s)
  井手健太郎, 大平真裕, 田原裕之, 谷峰直樹, 秋本修志, 今岡祐輝, 佐藤幸毅, 山根宏昭, 井出隆太, 築山尚史, 小野紘輔, 望月哲矢, 田中友加, 大段秀樹
- Organizer
  第56回日本移植学会総会
- Data Source
  KAKENHI-PROJECT-20K20391
[Presentation] 血液型不適合腎移植における免疫解析2019
- Author(s)
  森本博司、井手健太郎,田原裕之,大平真裕,田中友加,大段秀樹
- Organizer
  第55回日本移植学会総会
- Data Source
  KAKENHI-PROJECT-19H01057
[Presentation] ヒトiPS細胞からの機能性NK細胞分化誘導法の確立2019
- Author(s)
  秋本修志、田中友加, Doskali Marlen, 築山尚史, 井出隆太, Akhmet Seidakhmetov, 山根宏昭, 佐藤幸毅, 今岡祐輝, 本明慈彦, 中島一記, Jamilya Saparbay, 田口和浩, 田中飛鳥, 谷峰直樹, 森本博司, 田原裕之, 大平真裕, 井手健太郎, 小林剛, 大段秀樹
- Organizer
  第55回日本移植学会総会
- Data Source
  KAKENHI-PROJECT-20K20391
[Presentation] ヒト化マウスを用いた抗HLA抗体産生機序の解明へ向けて2019
- Author(s)
  田原裕之
- Organizer
  第21回日本異種移植研究会
- Data Source
  KAKENHI-PROJECT-18K08597
[Presentation] 抗ドナー抗体産生マウスモデルにおける抗体産生抑制効果2016
- Author(s)
  田原　裕之
- Organizer
  第18回日本異種移植研究会
- Place of Presentation
  長崎
- Year and Date
  2016-02-20
- Data Source
  KAKENHI-PROJECT-15K10025
[Presentation] ヒト化マウスを用いた異種免疫寛容モデルの構築2015
- Author(s)
  田原裕之
- Organizer
  第17回日本異種移植研究会
- Place of Presentation
  栃木
- Year and Date
  2015-03-14
- Data Source
  KAKENHI-PROJECT-25893143
[Presentation] 当科における異種移植研究の変遷と新たな試み2015
- Author(s)
  田原裕之
- Organizer
  第42回日本臓器保存生物医学会学術集会
- Place of Presentation
  岩手
- Year and Date
  2015-11-13
- Data Source
  KAKENHI-PROJECT-15K10025
[Presentation] Establishment of a model for immune tolerance in allogeneic or xenogeneic transplantation using a next generation humanized mouse model2014
- Author(s)
  田原裕之
- Organizer
  第114回日本外科学会定期学術集会
- Place of Presentation
  京都
- Year and Date
  2014-04-03
- Data Source
  KAKENHI-PROJECT-25893143
[Presentation] 次世代ヒト化マウスを用いた同種および異種移植における免疫寛容モデルの確立
- Author(s)
  田原裕之
- Organizer
  日本外科学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25893143

1. Ohdan Hideki (10363061)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
2. 田中友加 (90432666)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
3. 大平真裕 (30397947)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. 井手健太郎 (50511565)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
5. 田原栄俊 (00271065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. 小林剛 (50528007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. 山本卓 (90244102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 柳川泉一郎

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Tahara Hiroyuki 田原 裕之

TAHARA HIROYUKI 田原 裕之

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism of cancer immune evasion by glycan-responsive B cells and development of regulatory methods

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of antibody-related rejection and clinical application using anti-donor-specific HLA antibody-producing humanized micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of therapeutic methods for controlling novel cancer immune-evasion mechanisms by non-conventional B cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of anti-donor specific HLA antibody production mechanism using a humanized mouse model and clinical application for individualized treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of novel rejection mechanism after HLA-matched transplantation using allogeneic iPS cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a novel regulating method for allogeneic or xenogeneic antibody-mediated rejection using a humanized mousePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of mechanism of antibody-related rejection bay using humanized immunodeficient mice lacking xenogeneic antigenPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] ユニークな表現型を示すB細胞による癌関連ペプチド抗原に対するT細胞応答2023

Author(s)

Journal Title

Data Source

[Journal Article] Heterophile carbohydrate antigen N‐glycolylneuraminic acid as a potential biomarker in patients with hepatocellular carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] History and future prospects of HLA antibody-producing humanized mouse models2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Development of a humanized mouse model to analyze antibodies specific for human leukocyte antigen (HLA)2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 当科における異種移植研究の変遷と今後の展望2016

Author(s)

Journal Title

NAID

Data Source

[Presentation] ドナー抗原特異的HLA抗体産生ヒト化マウスモデルによる抗体産生メカニズムの解明2023

Author(s)

Organizer

Data Source

[Presentation] SNPによる免疫応答への影響解析を目的としたPrime editing法によるIL-1B SNP改変株の作成2023

Author(s)

Organizer

Tahara Hiroyuki 田原裕之

TAHARA HIROYUKI 田原裕之

[Presentation] 異種糖鎖抗原NeuGc発現肝細胞癌の腫瘍学的特性と早期再発を予測しうるバイオマーカーとしての可能性2021

[Presentation] 肝移植におけるHLA抗体検査の意義エピトープ解析と免疫応答の関連性についての検討2020