Kikuchi Atsuo 菊池敦生

… Alternative Names

KIKUCHI Atsuo 菊池敦生

Less

Researcher Number	30447156
Other IDs	https://orcid.org/0000-0003-1002-8739
Affiliation (Current)	2025: 東北大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 東北大学, 医学系研究科, 教授 2013 – 2022: 東北大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related / Epidemiology and preventive medicine
Keywords	Principal Investigator 小児神経学 / 新規候補遺伝子 / 環境要因 / ミトコンドリア病 / 造血 / 希少疾患 / ゲノム編集マウス / Bリンパ球 / 胎盤 / 遺伝学 … More / コンディショナルノックアウトマウス / 新規病因遺伝子 / 脂質代謝 / コレステロール合成経路 / 無毛症 / 低分子RNA / ミトコンドリア / 髄鞘化 / バルプロ酸 / エピジェネティクス / 葉酸代謝 / 葉酸代謝異常 / 神経管欠損症 … More Except Principal Investigator 肺胞上皮幹細胞 / サーファクタント / 肺胞傷害 / 肺胞上皮細胞 / 動物モデル / 全エクソーム解析 / 一次性ネフローゼ症候群 / 同胞発症例 / ステロイド依存性 / 同胞発症家系 / ゲノム解析 / ステロイド感受性 / ネフローゼ症候群 / 肺血管内皮細胞 / 抗線維化薬 / 肺血管拡張薬 / 間質性肺炎 / 早産低出生体重児 / 慢性肺疾患 / 肺発達 / 線維化 / 気腫 / 肺ボリュメトリ / 肺高血圧 / 肺volumetry / 肺発生 / 肺高血圧症 / 未熟児慢性肺疾患 / 食嗜好 / SLC25A13 / 小児期 / 分子遺伝疫学 / スクリーニング / シトリン欠損症 / 小児間質性肺炎 / 2型肺胞上皮細胞 / サーファクタント蛋白 / FACS / 薬剤スクリーニング / 薬物スクリーニング / 小児 / 分化誘導法 / 肺線維化 / 肺胞修復 / 肺胞上皮前駆細胞 / ABCA3 / 遺伝性間質性肺炎 / 小頭症 / 臨床 / 脳神経疾患 / 遺伝学 / 遺伝性痙性対麻痺 / てんかん性脳症 / 痙性対麻痺 / 全エキソーム解析 / MRI / 満期産 / 遺伝子 / 脳性麻痺 / Macular mouse / 銅補充療法 / 銅錯体 / Ｍｅｎｋｅｓ病 / macular mouse / Menkes病 Less

Elucidating the mechanism underlying the exacerbation of a novel mitochondrial disease caused by environmental factors, targeting mouse model therapy.Principal Investigator
- Principal Investigator
  
  菊池敦生
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tohoku University
Proof of a novel gene underlying B lymphocyte deficiency using genome-edited micePrincipal Investigator
- Principal Investigator
  
  Kikuchi Atsuo
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tohoku University
Investigation of the pathophysiology and the treatment for pulmonary fibrosis associated with bronchopulmonary dysplasia
- Principal Investigator
  
  Ota Chiharu
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tohoku University
Genomic analysis of steroid-sensitive nephrotic syndrome using sibling cases
- Principal Investigator
  
  KURE Shigeo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tohoku University
Identification of a novel gene causing cholesterol synthesis deficiencyPrincipal Investigator
- Principal Investigator
  
  Kikuchi Atsuo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tohoku University
Genetic background of unexplained full-term cerebral palsy
- Principal Investigator
  
  Haginoya Kazuhiro
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tohoku University
Investigating the drugs to repair injured alveolar epithelial cells using type 2 alveolar epithelial progenitor cells with ABCA3 mutations
- Principal Investigator
  
  Ota Chiharu
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tohoku University
A new pathogenesis of myelin-related disorders: a dysfunction of small RNA import into mitochondriaPrincipal Investigator
- Principal Investigator
  
  Kikuchi Atsuo
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Tohoku University
Establishment of a simple screening method for citrin deficiency and exploration on food preferences
- Principal Investigator
  
  Kuriyama Shinichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Epidemiology and preventive medicine
- Research Institution
  Tohoku University
New therapeutic approach using functional copper complexes to treat Menkes disase.
- Principal Investigator
  
  Munakata Mitsutoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tohoku University
The reason why valproic acid leads to neural tube defct: an analysis using folate-associated gene deficient micePrincipal Investigator
- Principal Investigator
  
  KIKUCHI Atsuo
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Tohoku University

All 2020 2019 2018 2016 2015

All Journal Article Presentation

[Journal Article] Metabolic and pathologic profiles of human LSS deficiency recapitulated in mice2020
- Author(s)
  Wada Yoichi、Kikuchi Atsuo、Kaga Akimune、Shimizu Naoki、Ito Junya、Onuma Ryo、Fujishima Fumiyoshi、Totsune Eriko、Sato Ryo、Niihori Tetsuya、Shirota Matsuyuki、Funayama Ryo、Sato Kota、Nakazawa Toru、Nakayama Keiko、Aoki Yoko、Aiba Setsuya、Nakagawa Kiyotaka、Kure Shigeo
- Journal Title
  
  PLOS Genetics
  
  Volume: 16 Issue: 2 Pages: e1008628-e1008628
- DOI
  10.1371/journal.pgen.1008628
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04795, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-17K10044, KAKENHI-PROJECT-18K19281
[Journal Article] Biallelic variants/mutations of IL1RAP in patients with steroid-sensitive nephrotic syndrome2019
- Author(s)
  Niitsuma Sou、Kudo Hiroki、Kikuchi Atsuo、Hayashi Takaya、Kumakura Satoshi、Kobayashi Shuhei、Okuyama Yuko、Kumagai Naonori、Niihori Tetsuya、Aoki Yoko、So Takanori、Funayama Ryo、Nakayama Keiko、Shirota Matsuyuki、Kondo Shuji、Kagami Shoji、Tsukaguchi Hiroyasu、Iijima Kazumoto、Kure Shigeo、Ishii Naoto
- Journal Title
  
  International Immunology
  
  Volume: 32 Issue: 4 Pages: 283-292
- DOI
  10.1093/intimm/dxz081
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09719, KAKENHI-PUBLICLY-18H04795, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-18H02572, KAKENHI-PROJECT-17K08875, KAKENHI-PROJECT-18K19281, KAKENHI-PROJECT-19H03612, KAKENHI-PROJECT-18KK0244
[Journal Article] Genomic analysis identifies masqueraders of full-term cerebral palsy2018
- Author(s)
  Yusuke Takezawa, Atsuo Kikuchi, Kazuhiro Haginoya, Takehiko Inui, Noriko Togashi, Mai Anzai, Sato Suzuki-Muromoto, Takuya Miyabayashi, Wakaba Endo, Yukimune Okubo, Yasuko Kobayashi, Akira Onuma, Shigeo Kure, Yoko Aoki, Keiko Nakayama, Ryo Funayama, Matsuyuki Shirota, Saeko Yamamura-Suzuki
- Journal Title
  
  Annals of Clinical and Translational Neurology
  
  Volume: 5 Issue: 5 Pages: 538-551
- DOI
  10.1002/acn3.551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09983
[Journal Article] Reply to: A genomic cause of cerebral palsy should not change the clinical classification.2018
- Author(s)
  Takezawa Y, Kikuchi A, Haginoya K, Kure S.
- Journal Title
  
  Annals of Clinical and Translational Neurology
  
  Volume: 5 Issue: 8 Pages: 1012-1012
- DOI
  10.1002/acn3.585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09983
[Journal Article] Patchy white matter hyperintensity in ring chromosome 18 syndrome.2016
- Author(s)
  Anzai M, Arai-Ichinoi N, Takezawa Y, Endo W, Inui T, Sato R, Kikuchi A, Uematsu M, Kure S, Haginoya K.
- Journal Title
  
  Pediatric International
  
  Volume: 58 Issue: 9 Pages: 919-922
- DOI
  10.1111/ped.13043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19597
[Journal Article] Protocol and Research Perspectives of the ToMMo Child Health Study after the 2011 Great East Japan Earthquake2015
- Author(s)
  Masako Miyashita, Mami Ishikuro, Masahiro Kikuya, Chizuru Yamanaka, Satoshi Mizuno, Masato Nagai, Yuki Sato, Taku Obara, Hirohito Metoki, Atsuo Kikuchi, Naoki Nakaya, Atsushi Hozawa, Ichiro Tsuji, Nobuo Yaegashi, Masayuki Yamamoto, Shigeo Kure and Shinichi Kuriyama
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 236 Issue: 2 Pages: 123-130
- DOI
  10.1620/tjem.236.123
- NAID
  130005074327
- ISSN
  0040-8727, 1349-3329
- URL
  https://localhost/en/publications/aa5c25e0-c431-463f-b9e6-feee1ba5b855
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15217
[Journal Article] Genetic heterogeneity in 26 infants with a hypomyelinating leukodystrophy.2015
- Author(s)
  Arai-Ichinoi N, Uematsu M, Sato R, Suzuki T, Kudo H, Kikuchi A, et al.
- Journal Title
  
  Human Genetics
  
  Volume: 1 Issue: 1 Pages: 1-10
- DOI
  10.1007/s00439-015-1617-7
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19597, KAKENHI-PROJECT-25461533
[Presentation] 小児期発症頚性対麻痺91例の臨床的・遺伝学的解析2019
- Author(s)
  萩野谷和裕、竹澤祐介、菊池敦生、呉繁夫
- Organizer
  第６１回小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09983
[Presentation] Clinical and Genetic Analysis of 91 Patients with Childhood Onset Spastic Paraplegia2019
- Author(s)
  Hginoya K, Takezawa Y, Kikuchi A, Haginoya K
- Organizer
  American Academy of Cerebral Palsy and Developmental Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09983

1. Ota Chiharu (00733106)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. KURE Shigeo (10205221)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 木村正人 (80646894)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. Munakata Mitsutoshi (30312573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KODAMA Hiroko (00093386)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Haginoya Kazuhiro (00208414)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. Kuriyama Shinichi (90361071)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KIKUYA Masahiro (80361111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. ISHIKURO Mami (10632242)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MIYASHITA Masako (70765429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 丹藤由希子 (70596212)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 仲川清隆 (80361145)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 山田充啓 (00396483)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 埴田卓志 (30400360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 小山涼子 (30733349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 大田英揮 (40586905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 石井直人 (60291267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 塚口裕康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 中山啓子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kikuchi Atsuo 菊池 敦生

KIKUCHI Atsuo 菊池 敦生

Research Projects

Research Products

Co-Researchers

Elucidating the mechanism underlying the exacerbation of a novel mitochondrial disease caused by environmental factors, targeting mouse model therapy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Proof of a novel gene underlying B lymphocyte deficiency using genome-edited micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the pathophysiology and the treatment for pulmonary fibrosis associated with bronchopulmonary dysplasia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Genomic analysis of steroid-sensitive nephrotic syndrome using sibling cases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of a novel gene causing cholesterol synthesis deficiencyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genetic background of unexplained full-term cerebral palsy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigating the drugs to repair injured alveolar epithelial cells using type 2 alveolar epithelial progenitor cells with ABCA3 mutations

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A new pathogenesis of myelin-related disorders: a dysfunction of small RNA import into mitochondriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of a simple screening method for citrin deficiency and exploration on food preferences

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

New therapeutic approach using functional copper complexes to treat Menkes disase.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The reason why valproic acid leads to neural tube defct: an analysis using folate-associated gene deficient micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Metabolic and pathologic profiles of human LSS deficiency recapitulated in mice2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biallelic variants/mutations of IL1RAP in patients with steroid-sensitive nephrotic syndrome2019

Author(s)

Journal Title

DOI

Kikuchi Atsuo 菊池敦生

KIKUCHI Atsuo 菊池敦生