Kato Taisuke 加藤泰介

Researcher Number	30598496
Other IDs
Affiliation (Current)	2025: 新潟大学, 脳研究所, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 新潟大学, 脳研究所, 准教授 2017 – 2020: 新潟大学, 脳研究所, 特任准教授 2014 – 2016: 新潟大学, 脳研究所, 特別研究員
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Basic Section 63020:Radiation influence-related / Medium-sized Section 52:General internal medicine and related fields / Pathological medical chemistry Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields / Nerve anatomy/Neuropathology / Neurology
Keywords	Principal Investigator 細胞老化 / 脳小血管病 / 老化 / 細胞外マトリクス / CARASIL / シングルセルRNA-seq / 細胞外マトリックス / 病因形質獲得細胞 / シングルRNA-seq / カンデサルタン … More / シングルセルトランスクリプトーム / 細胞質2本鎖DNA / DNA損傷 / 細胞質核酸 / 封入体シード / 細胞質封入体 / TDP-43プロテイノパチー / DNA damage / SASP / 二本鎖DNA切断 / DNA損傷毒性 / RVCL / TREX1 / 血管平滑筋細胞 / TGF-β / TGFβシグナル / pericyte / smooth muscle cell / HTRA1 / small vessel disease / TGFβ … More Except Principal Investigator 脳小血管病 / 脳小血管 / 認知症 / 透明化 / 一細胞解析 / 一細胞オミックス / 細胞外マトリックス / 加齢 / リンパ管 / フィブロネクチン / 細胞外基質 / カンデサルタン / 血管 / 老化 / Globular glial tauopathy / ４-リピートタウ / globular glial tauopathy / 皮質基底核変性症 / 進行性核上性麻痺 / 4-リピートタウ / アストロサイト / タウオパチー / 蛋白質 / HTRA1 / CARASIL / タンパク質 / 痴呆 / 病理学 / 循環器 / 脳神経疾患 / 脳血管障害 Less

TREX1に着目した遅発性放射線脳壊死の病態機序の解明と制御法開発Principal Investigator
- Principal Investigator
  
  加藤泰介
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Niigata University
Identification of cell groups that perturb the extracellular matrix of cerebral small vessel disease and deciphering their regulatory mechanisms.
- Principal Investigator
  
  小野寺理
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Niigata University
脳小血管線維化促進細胞の同定による脳小血管老化の解明Principal Investigator
- Principal Investigator
  
  加藤泰介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Niigata University
Challenges to the true molecular mechanism of TDP-43 proteinopathy from the aspect of cellular senescence.Principal Investigator
- Principal Investigator
  
  Kato Taisuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Niigata University
Approach to neurodegenerative disorders by elucidation of the excretion pathway of the brain.
- Principal Investigator
  
  ONODERA OSMAU
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Niigata University
Elucidation of the mechanism of gain-of-toxic function by abnormal subcellular localization of cerebral small vessel disease-related mutant TREX1Principal Investigator
- Principal Investigator
  
  Kato Taisuke
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Niigata University
Tauopathy affecting astrocytes: diversity in the tau pathology and the astrocytic molecular feature
- Principal Investigator
  
  Takahashi Hitoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Niigata University
Strategies for overcoming vascular dementia focusing on dynamic functions of cerebral small vessels.
- Principal Investigator
  
  Onodera Osamu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Impact of the excess TGFbeta signaling on blood vessel integrity in the brainPrincipal Investigator
- Principal Investigator
  
  Kato Taisuke
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Niigata University

All 2023 2021 2020 2019 2017 2016 2015 Other

All Journal Article Presentation Patent

[Journal Article] Candesartan prevents arteriopathy progression in cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy model2021
- Author(s)
  Kato T, Manabe RI, Igarashi H, Kametani F, Hirokawa S, Sekine Y, Fujita N, Saito S, Kawashima Y, Hatano Y, Ando S, Nozaki H, Sugai A, Uemura M, Fukunaga M, Sato T, Koyama A, Saito R, Sugie A, Toyoshima Y, Kawata H, Murayama S, Matsumoto M, Kakita A, Hasegawa M, Ihara M, Kanazawa M, Nishizawa M, Tsuji S, Onodera O.
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 131 Issue: 22
- DOI
  10.1172/jci140555
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05930, KAKENHI-PROJECT-19H01043, KAKENHI-PROJECT-20K21386, KAKENHI-PROJECT-16H06280, KAKENHI-PROJECT-20K07880
[Journal Article] HTRA1-Related Cerebral Small Vessel Disease: A Review of the Literature2020
- Author(s)
  Uemura Masahiro、Nozaki Hiroaki、Kato Taisuke、Koyama Akihide、Sakai Naoko、Ando Shoichiro、Kanazawa Masato、Hishikawa Nozomi、Nishimoto Yoshinori、Polavarapu Kiran、Nalini Atchayaram、Hanazono Akira、Kuzume Daisuke、Shindo Akihiro、El-Ghanem M、Abe A、Sato A、Yoshida M、Ikeuchi T、Mizuta I、Mizuno T、Onodera O
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 11 Pages: 545-545
- DOI
  10.3389/fneur.2020.00545
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07493, KAKENHI-PROJECT-19H01043
[Journal Article] Ectopic expression induces abnormal somatodendritic distribution of tau in the mouse brain.2019
- Author(s)
  Kubo A, Ueda S, Yamane A, Wada-Kakuda S, Narita M, Matsuyama M, Nomori A, ..... Murayama S, Ihara Y, Misonou H, Miyasaka T
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 39 Issue: 34 Pages: 6781-6797
- DOI
  10.1523/jneurosci.2845-18.2019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-19H01043
[Journal Article] Non-genetically modified models exhibit TARDBP mRNA increase due to perturbed TDP-43 autoregulation2019
- Author(s)
  Sugai Akihiro、Kato Taisuke、Koyama Akihide、Koike Yuka、Konno Takuya、Ishihara Tomohiko、Onodera Osamu
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 130 Pages: 104534-104534
- DOI
  10.1016/j.nbd.2019.104534
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09750, KAKENHI-PROJECT-17K09751, KAKENHI-PROJECT-19H01043
[Journal Article] HTRA1 Mutations Identified in Symptomatic Carriers Have the Property of Interfering the Trimer-Dependent Activation Cascade2019
- Author(s)
  Uemura Masahiro、Nozaki Hiroaki、Koyama Akihide、Sakai Naoko、Ando Shoichiro、Kanazawa Masato、Kato Taisuke、Onodera Osamu
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 10 Pages: 693-693
- DOI
  10.3389/fneur.2019.00693
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07493, KAKENHI-PROJECT-19H01043
[Journal Article] Distinct molecular mechanisms of HTRA1 mutants in manifesting heterozygotes with CARASIL.2016
- Author(s)
  Nozaki H, Kato T, Nihonmatsu M, Saito Y, Mizuta I, Noda T, Koike R, Miyazaki K, Kaito M, Ito S, Makino M, Koyama A, Shiga A, Uemura M, Sekine Y, Murakami A, Moritani S, Hara K, Yokoseki A, Kuwano R, Endo N, Momotsu T, Yoshida M, Nishizawa M, Mizuno T, Onodera O
- Journal Title
  
  Neurology
  
  Volume: 86 Issue: 21 Pages: 1-10
- DOI
  10.1212/wnl.0000000000002694
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461276, KAKENHI-PLANNED-26117006, KAKENHI-PROJECT-16H02656
[Patent] 小脳血管病の予防又は治療用医薬組成物2020
- Inventor(s)
  小野寺理　加藤泰介
- Industrial Property Rights Holder
  小野寺理　加藤泰介
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19H01043
[Presentation] Age-related changes in brain vessels of a cerebral small-vessel disease model and response to therapeutic agents as shown by scRNA-seq.2023
- Author(s)
  Taisuke Kato, Yuya Hatano, Osamu Onodera
- Organizer
  Cell symposia "Conceptual Power of Single-Cell Biology"
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24242
[Presentation] Nuclear export and reduced enzyme activity of TREX1 improve cell growth arrest due to RVCL mutation2020
- Author(s)
  安藤昭一朗、加藤泰介、野崎洋明、笠原杏子、小野寺理
- Organizer
  第61回日本神経学会総会
- Data Source
  KAKENHI-PROJECT-18K07522
[Presentation] RVCL関連変異の細胞内局在についての検討．2017
- Author(s)
  笠原杏子, 加藤泰介, 野崎洋明, 小山哲秀, 小野寺理．
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] Distinct mechanisms of HTRA1 mutants in manifesting heterozygotes with CARASIL2017
- Author(s)
  野崎洋明, 加藤泰介, 水田依久子, 水野敏樹, 西澤正豊,小野寺理
- Organizer
  第114回日本内科学会総会
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] セリンプロテアーゼHTRA1の機能欠損は、脳小血管病を引き起こす; Serine protease HTRA1 deficiency induces arteriopathy in cerebral small vessels2017
- Author(s)
  Kato T, Sekine Y, Fujita N, Nozaki H, Hirokawa S, Sato T, Onodera O
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] The prevalence estimates of HTRA1-associated cerebral small vessel disease2017
- Author(s)
  Hiroaki Nozaki, Akihide Koyama, Masahiro Uemura, Taisuke Kato, Osamu Onodera
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] 家族性脳小血管病患者で同定された変異型HTRA1蛋白質のプロテアーゼ活性解析2017
- Author(s)
  上村昌寛, 野崎洋明, 加藤泰介, 小山哲秀, 小野寺理
- Organizer
  第47回新潟神経学夏季セミナー
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] 家族性脳小血管病患者で報告された変異型HTRA1蛋白質の機能解析2017
- Author(s)
  上村昌寛, 野崎洋明, 加藤泰介, 小山哲秀, 小野寺理
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] Molecular analysis of mutant high-temperature requirement serine protease A1 identified in patients with familial cerebral small vessel disease2017
- Author(s)
  Uemura M, Nozaki H, Kato T, Koyama A, Onodera O
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] Protease activity analysis of mutant high-temperature requirement serine protease A1 identified in patients with familial cerebral small vessel disease2017
- Author(s)
  Uemura M, Nozaki H, Kato T, Koyama A, Onodera O
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] The prevalence estimates of HTRA1-associated cerebral small vessel disease2017
- Author(s)
  Hiroaki Nozaki, Akihide Koyama, Masahiro Uemura, Taisuke Kato, Osamu Onodera
- Organizer
  The 8th Korea-Japan Joint Stroke Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] Molecular analysis of mutant high-temperature requirement serine protease A1 identified in patients with familial cerebral small vessel disease2017
- Author(s)
  Uemura M, Nozaki H, Kato T, Koyama A, Onodera O
- Organizer
  Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] Distinct Molecular Mechanisms of Htra1 Mutants in Manifesting Heterozygotes With Carasil.2017
- Author(s)
  Hiroaki Nozaki, Taisuke Kato, Megumi Nihonmatsu, Yohei Saito, Osamu Onodera, et al.
- Organizer
  International stroke conference 2017
- Place of Presentation
  Houston (USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] Impact of the excess TGF-β signaling on blood vessel integrity in the brain： TGF-βシグナル亢進による脳血管に与える影響2015
- Author(s)
  加藤　泰介
- Organizer
  第38回日本神経科学学会
- Place of Presentation
  神戸国際会議場・展示場（兵庫県神戸市）
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-26860208
[Presentation] TGF-βシグナル亢進による脳血管に与える影響; Impact of the excess TGF-β signaling on blood vessel integrity in the brain
- Author(s)
  加藤　泰介
- Organizer
  日本神経科学学会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-07-28 – 2015-07-31
- Data Source
  KAKENHI-PROJECT-26860208

1. Onodera Osamu (20303167)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
2. 豊島靖子 (20334675)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Takahashi Hitoshi (90206839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 小山哲秀 (90622209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. 野崎洋明 (20547567)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
6. 田中英智 (80612225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 上村昌寛 (00836710)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 五十嵐博中 (20231128)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 今野卓哉 (20837372)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 清水宏 (40608767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 金澤雅人 (80645101)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 塚田啓道 (40794087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 齋藤理恵 (80829078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 須貝章弘 (70758903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ISHIHARA Tomohiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. MIZUNO Toshiki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. MIZUTA Ikuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 森満

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 村山繁雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 松本雅記

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kato Taisuke 加藤 泰介

Research Projects

Research Products

Co-Researchers

TREX1に着目した遅発性放射線脳壊死の病態機序の解明と制御法開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of cell groups that perturb the extracellular matrix of cerebral small vessel disease and deciphering their regulatory mechanisms.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脳小血管線維化促進細胞の同定による脳小血管老化の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Challenges to the true molecular mechanism of TDP-43 proteinopathy from the aspect of cellular senescence.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Approach to neurodegenerative disorders by elucidation of the excretion pathway of the brain.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of gain-of-toxic function by abnormal subcellular localization of cerebral small vessel disease-related mutant TREX1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Tauopathy affecting astrocytes: diversity in the tau pathology and the astrocytic molecular feature

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Strategies for overcoming vascular dementia focusing on dynamic functions of cerebral small vessels.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Impact of the excess TGFbeta signaling on blood vessel integrity in the brainPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Candesartan prevents arteriopathy progression in cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy model2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HTRA1-Related Cerebral Small Vessel Disease: A Review of the Literature2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ectopic expression induces abnormal somatodendritic distribution of tau in the mouse brain.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Non-genetically modified models exhibit TARDBP mRNA increase due to perturbed TDP-43 autoregulation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HTRA1 Mutations Identified in Symptomatic Carriers Have the Property of Interfering the Trimer-Dependent Activation Cascade2019

Author(s)

Kato Taisuke 加藤泰介