Kobayashi Ryosuke 小林良祐

Researcher Number	30802855
Other IDs
Affiliation (Current)	2025: 酪農学園大学, 獣医学群, 助教
Affiliation (based on the past Project Information) *help	2024: 酪農学園大学, 獣医学群, 助教 2023: 群馬大学, 生体調節研究所, 研究員 2020 – 2022: 群馬大学, 生体調節研究所, 日本学術振興会特別研究員(PD) 2019: 群馬大学, 生体調節研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 42040:Laboratory animal science-related Except Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Basic Section 55020:Digestive surgery-related / Basic Section 48040:Medical biochemistry-related
Keywords	Principal Investigator エピゲノム / 子宮内膜がん / マウスモデル / ホメオスタシス / エンハンサー / H3K4メチル化 / KMT2ファミリー Except Principal Investigator エピジェネティクス / 多階層オミクス解析 / 抗がん剤感受性 … More / O-GlcNAc / KRAS / 新規治療標的 / O-GlcNAc修飾 / 膵がん / 子宮体癌 / エピゲノム編集 / ゲノム編集 / エピゲノム / 癌 Less

Innovative Combination Immunotherapy Targets Vulnerability of KMT2 Mutant Uterine Cancer
- Principal Investigator
  
  畑田出穂
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Gunma University
Analysis of the tumor suppressive enhancers that supports the endometrial homeostasisPrincipal Investigator
- Principal Investigator
  
  小林良祐
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Gunma University
膵がん治療におけるO-GlcNAc分解酵素OGAの重要性とその分子機構の解明
- Principal Investigator
  
  川端麗香
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University
Histone methyltransferase KMT2 mutation-induced epigenomic abnormalities and endometrial cancer development and progression
- Principal Investigator
  
  Hatada Izuho
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Gunma University
Development of KMT2-deficent animal models for studying endometrial cancerPrincipal Investigator
- Principal Investigator
  
  Kobayashi Ryosuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Gunma University

All 2023 2022 2021 2020 2019

All Journal Article Presentation Patent

[Journal Article] A Lipid Nanoparticle-Based Method for the Generation of Liver-Specific Knockout Mice2023
- Author(s)
  Morita Sumiyo、Horii Takuro、Kimura Mika、Kobayashi Ryosuke、Tanaka Hiroki、Akita Hidetaka、Hatada Izuho
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 18 Pages: 14299-14299
- DOI
  10.3390/ijms241814299
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15026, KAKENHI-PROJECT-23K05727
[Journal Article] Efficient Detection of Flox Mice Using In Vitro Cre Recombination2023
- Author(s)
  Kobayashi Ryosuke、Horii Takuro、Hatada Izuho
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2637 Pages: 149-159
- DOI
  10.1007/978-1-0716-3016-7_12
- ISBN
  9781071630150, 9781071630167
- Data Source
  KAKENHI-PROJECT-22K15026, KAKENHI-PROJECT-20J01824
[Journal Article] Generation of Floxed Mice by Sequential Electroporation2023
- Author(s)
  Horii Takuro、Kobayashi Ryosuke、Hatada Izuho
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2637 Pages: 135-147
- DOI
  10.1007/978-1-0716-3016-7_11
- ISBN
  9781071630150, 9781071630167
- Data Source
  KAKENHI-PROJECT-22K15026, KAKENHI-PROJECT-20J01824
[Journal Article] Aberrant activation of estrogen receptor‐α signaling in Mettl14‐deficient uteri impairs embryo implantation2023
- Author(s)
  Kobayashi Ryosuke、Kawabata‐Iwakawa Reika、Terakawa Jumpei、Sugiyama Makoto、Morita Sumiyo、Horii Takuro、Hatada Izuho
- Journal Title
  
  The FASEB Journal
  
  Volume: 37 Issue: 8
- DOI
  10.1096/fj.202300735r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15026, KAKENHI-PROJECT-23K05727
[Journal Article] The N6-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity2022
- Author(s)
  Yoshinaga Masanori、Han Kyuho、Morgens David W.、Horii Takuro、Kobayashi Ryosuke、Tsuruyama Tatsuaki、Hia Fabian、Yasukura Shota、Kajiya Asako、Cai Ting、Cruz Pedro H. C.、Vandenbon Alexis、Suzuki Yutaka、Kawahara Yukio、Hatada Izuho、Bassik Michael C.、Takeuchi Osamu
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 1-17
- DOI
  10.1038/s41467-022-34078-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15372, KAKENHI-PROJECT-22K15026, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-18H05278
[Journal Article] Multiplexed genome editing by in vivo electroporation of Cas9 ribonucleoproteins effectively induces endometrial carcinoma in mice2022
- Author(s)
  Kobayashi Ryosuke、Kawabata‐Iwakawa Reika、Sugiyama Makoto、Oyama Tetsunari、Ohtsuka Masato、Horii Takuro、Morita Sumiyo、Nishiyama Masahiko、Hatada Izuho
- Journal Title
  
  International Journal of Cancer
  
  Volume: 152 Issue: 11 Pages: 2331-2337
- DOI
  10.1002/ijc.34342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15026, KAKENHI-PROJECT-20H03431, KAKENHI-PROJECT-20J01824
[Journal Article] Improvement in identification of pro-estrous mice by using a novel method of detecting vaginal mucous cells.2021
- Author(s)
  Makoto Sugiyama, Arata Yasunaga, Ryosuke Kobayashi, Hanae Fukasawa, Osamu Hashimoto, Shiro Kurusu, Hiroshi Sasada, Kazuki Yoshioka
- Journal Title
  
  Cell and tissue research
  
  Volume: 383 Issue: 3 Pages: 1183-1190
- DOI
  10.1007/s00441-020-03310-w
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15965, KAKENHI-PROJECT-19K16021, KAKENHI-PROJECT-20J01824
[Journal Article] Viral-derived DNA invasion and individual variation in an Indonesian population of large flying fox <i>Pteropus vampyrus</i>2021
- Author(s)
  IIDA Atsuo、TAKEMAE Hitoshi、TARIGAN Ronald、KOBAYASHI Ryosuke、KATO Hirokazu、SHIMODA Hiroshi、OMATSU Tsutomu、Supratikno、BASRI Chaerul、MAYASARI Ni Luh Putu Ika、AGUNGPRIYONO Srihadi、MAEDA Ken、MIZUTANI Tetsuya、HONDO Eiichi
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 83 Issue: 7 Pages: 1068-1074
- DOI
  10.1292/jvms.21-0115
- NAID
  130008061652
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16021, KAKENHI-PROJECT-21H04637, KAKENHI-PROJECT-20J01824
[Journal Article] Vaginal mucus in mice: developmental and gene expression features of epithelial mucous cells during pregnancy2021
- Author(s)
  Sugiyama Makoto、Machida Nao、Yasunaga Arata、Terai Nanako、Fukasawa Hanae、Ono Hisaya K、Kobayashi Ryosuke、Nishiyama Keita、Hashimoto Osamu、Kurusu Shiro、Yoshioka Kazuki
- Journal Title
  
  Biology of Reproduction
  
  Volume: 105 Issue: 5 Pages: 1272-1282
- DOI
  10.1093/biolre/ioab157
- Data Source
  KAKENHI-PROJECT-19K15965, KAKENHI-PROJECT-19K16021, KAKENHI-PROJECT-20J01824, KAKENHI-PROJECT-21K19666
[Journal Article] Dispersal history of Miniopterus fuliginosus bats and their associated viruses in east Asia2021
- Author(s)
  Kimprasit T、Nunome M、Iida K、Murakami Y、Wong ML、Wu CH、Kobayashi R、Hengjan Y、Takemae H、Yonemitsu K、Kuwata R、Shimoda H、Si L、Sohn JH、Asakawa S、Ichiyanagi K、Maeda K、Oh HK、Mizutani T、Kimura J、Iida A、Hondo E
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 1 Pages: 0244006-0244006
- DOI
  10.1371/journal.pone.0244006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16021, KAKENHI-PROJECT-20J01824
[Journal Article] Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity2020
- Author(s)
  Kohro Yuta、（他２０名）、Mikoshiba Katsuhiko、Taylor Verdon、Inoue Kazuhide、Tsuda Makoto
- Journal Title
  
  Nature Neuroscience
  
  Volume: 23 Issue: 11 Pages: 1376-1387
- DOI
  10.1038/s41593-020-00713-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06864, KAKENHI-PROJECT-19K16021, KAKENHI-PROJECT-20K16133, KAKENHI-ORGANIZER-20H05894, KAKENHI-PLANNED-20H05900, KAKENHI-PROJECT-19H05658, KAKENHI-PROJECT-19J21063, KAKENHI-PROJECT-19J21452, KAKENHI-PROJECT-20J01824
[Journal Article] Calcium-Free and Cytochalasin B Treatment Inhibits Blastomere Fusion in 2-Cell Stage Embryos for the Generation of Floxed Mice via Sequential Electroporation2020
- Author(s)
  Horii T, Kobayashi R, Kimura M, Morita S, Hatada I.
- Journal Title
  
  Cells
  
  Volume: 9 Issue: 5 Pages: 1088-1088
- DOI
  10.3390/cells9051088
- NAID
  130007925824
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03143, KAKENHI-PROJECT-19K06607, KAKENHI-PROJECT-19K16021, KAKENHI-PROJECT-20J01824
[Patent] 生体内ゲノム編集による効率的な子宮癌発症マウス作出法2021
- Inventor(s)
  畑田出穂、小林良祐
- Industrial Property Rights Holder
  畑田出穂、小林良祐
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-189718
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19K16021
[Presentation] 子宮特異的Mettl14欠損は着床不全による不妊を誘発する2023
- Author(s)
  小林良祐, 川端麗香, 寺川純平, 杉山真言, 森田純代, 堀居拓郎, 畑田出穂
- Organizer
  第16回日本エピジェネティクス研究会
- Data Source
  KAKENHI-PROJECT-22K15026
[Presentation] RNAメチル化制御異常による雌性不妊の分子機序2023
- Author(s)
  小林良祐, 川端麗香, 寺川純平, 杉山真言, 森田純代, 堀居拓郎, 畑田出穂
- Organizer
  第46回日本分子生物学会総会
- Data Source
  KAKENHI-PROJECT-22K15026
[Presentation] In vivoゲノム編集による子宮内膜がんモデルマウスの迅速作製2023
- Author(s)
  小林良祐, 川端麗香, 杉山真言, 小山徹也, 大塚正人, 堀居拓郎, 森田純代, 西山正彦, 畑田出穂
- Organizer
  第70回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-22K15026
[Presentation] 子宮内膜がんモデルマウスの迅速作製を実現するマルチプレックスin vivoゲノム編集技術2023
- Author(s)
  小林良祐, 川端麗香, 杉山真言, 小山徹也, 大塚正人, 堀居拓郎, 森田純代, 西山正彦, 畑田出穂
- Organizer
  日本ゲノム編集学会第8回大会
- Data Source
  KAKENHI-PROJECT-22K15026
[Presentation] ヒストンメチル基転移酵素に変異を伴う子宮内膜がんにおけるエピゲノム異常2022
- Author(s)
  小林良祐, 川端麗香, 横堀武彦, 堀居拓郎, 西山正彦, 畑田出穂
- Organizer
  第81回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15026
[Presentation] Epigenetic dysregulations in the lysine methyltransferase (KMT2) deficient endometrial cancer cells.2022
- Author(s)
  Ryosuke Kobayashi, Reika Kawabata-Iwakawa, Makoto Sugiyama, Takehiko Yokobori, Sumiyo Morita, Takuro Horii, Masahiko Nishiyama, Izuho Hatada
- Organizer
  The 17th International Symposium of The Institute Network, Kanazawa, Japan.
- Data Source
  KAKENHI-PROJECT-22K15026
[Presentation] ヒト子宮内膜がん細胞におけるKMT2変異の意義2022
- Author(s)
  小林良祐、川端麗香、杉山真言、横堀武彦、森田純代、堀居拓郎、西山正彦、畑田出穂
- Organizer
  第15回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-20H03431
[Presentation] KMT2欠損によるエピゲノム異常はヒト子宮内膜がん細胞で上皮関連遺伝子の発現を障害する2022
- Author(s)
  小林良祐, 川端麗香, 杉山真言, 横堀武彦, 森田純代, 堀居拓郎, 西山正彦, 畑田出穂
- Organizer
  第45回日本分子生物学会総会
- Data Source
  KAKENHI-PROJECT-22K15026
[Presentation] ヒト子宮内膜がん細胞におけるKMT2変異の意義2022
- Author(s)
  小林良祐, 川端麗香, 杉山真言, 横堀武彦, 森田純代, 堀居拓郎, 西山正彦, 畑田出穂
- Organizer
  第１５回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-22K15026
[Presentation] 2ステップ法によるfloxマウス作製支援の状況と効率化に向けた試み2021
- Author(s)
  小林良祐, 堀居拓郎, 末友恵理子, 木村美香, 森田純代, 畑田出穂
- Organizer
  第44回日本分子生物学会総会
- Data Source
  KAKENHI-PROJECT-19K16021
[Presentation] 次世代型疾患モデル動物作出遺伝子改変マウスを効率よく作製・供給するための試み2020
- Author(s)
  小林良祐
- Organizer
  第163回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16021
[Presentation] 交配を必要としない条件付きノックアウトマウス作製に向けた試み：3段階式ゲノム編集2020
- Author(s)
  小林良祐 , 堀居拓郎 , 末友恵理子 , 木村美香 , 森田純代 , 畑田出穂
- Organizer
  第43回日本分子生物学会総会
- Data Source
  KAKENHI-PROJECT-19K16021
[Presentation] ゲノム編集を用いて作製したfloxマウスの迅速なスクリーニング法2019
- Author(s)
  小林良祐、堀居拓郎、川田結花、末友恵理子、木村美香、森田純代、畑田出穂
- Organizer
  第66回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-19K16021
[Presentation] Creリコンビナーぜを利用したfloxマウスの効率的なジェノタイピング法2019
- Author(s)
  小林良祐、堀居拓郎、川田結花、末友恵理子、木村美香、森田純代、畑田出穂
- Organizer
  日本ゲノム編集学会第４回大会
- Data Source
  KAKENHI-PROJECT-19K16021
[Presentation] In vitro Creリコンビネーション法によるfloxマウスの迅速な選抜2019
- Author(s)
  小林良祐、堀居拓郎、川田結花、末友恵理子、木村美香、森田純代、畑田出穂
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16021
[Presentation] 条件付きノックアウトマウスの迅速な作製および選抜法の開発2019
- Author(s)
  小林良祐、堀居拓郎、川田結花、末友恵理子、木村美香、森田純代、畑田出穂
- Organizer
  日本獣医学会第162回大会
- Data Source
  KAKENHI-PROJECT-19K16021

1. Hatada Izuho (50212147)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. 堀居拓郎 (00361387)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. 森田純代 (40589264)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 川端麗香 (90721928)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. 横堀武彦 (60420098)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 西山正彦 (20198526)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 大日方英 (50332557)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 調憲 (70264025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 安部由美子 (70261857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Yoshinaga Masanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 御子柴克彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 杉山真言

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kobayashi Ryosuke 小林 良祐

Research Projects

Research Products

Co-Researchers

Innovative Combination Immunotherapy Targets Vulnerability of KMT2 Mutant Uterine Cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the tumor suppressive enhancers that supports the endometrial homeostasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

膵がん治療におけるO-GlcNAc分解酵素OGAの重要性とその分子機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Histone methyltransferase KMT2 mutation-induced epigenomic abnormalities and endometrial cancer development and progression

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of KMT2-deficent animal models for studying endometrial cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] A Lipid Nanoparticle-Based Method for the Generation of Liver-Specific Knockout Mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficient Detection of Flox Mice Using In Vitro Cre Recombination2023

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Generation of Floxed Mice by Sequential Electroporation2023

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Aberrant activation of estrogen receptor‐α signaling in Mettl14‐deficient uteri impairs embryo implantation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The N6-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multiplexed genome editing by in vivo electroporation of Cas9 ribonucleoproteins effectively induces endometrial carcinoma in mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Improvement in identification of pro-estrous mice by using a novel method of detecting vaginal mucous cells.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Viral-derived DNA invasion and individual variation in an Indonesian population of large flying fox <i>Pteropus vampyrus</i>2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Vaginal mucus in mice: developmental and gene expression features of epithelial mucous cells during pregnancy2021

Kobayashi Ryosuke 小林良祐

[Presentation] 次世代型疾患モデル動物作出遺伝子改変マウスを効率よく作製・供給するための試み2020