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DANBARA Hirofumi  檀原 宏文

ORCIDConnect your ORCID iD *help
… Alternative Names

檀原 宏文  ダンバラ ヒロフミ

DANBARA Hirobumi  檀原 宏文

壇原 宏文  ダンバラ ヒロフミ

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Researcher Number 40114558
Affiliation (Current) 2025: 北里大学, 薬学部, 名誉教授
Affiliation (based on the past Project Information) *help 2006 – 2007: 北里大学, 薬学部, 教授
1992 – 1999: 北里大学, 薬学部, 教授
1991: 北里研究所, 部長
1989: Department of Bacteriology, Kitasato Institute Section Head (Shitsu-cho), 室長
1988 – 1989: 北里研究所, 細菌部第2室, 室長
Review Section/Research Field
Principal Investigator
Bacteriology (including Mycology) / 細菌学 / Bacteriology (including Mycology)
Except Principal Investigator
Bacteriology (including Mycology) / 細菌学 / 免疫の制御機構
Keywords
Principal Investigator
サルモネラ / Salmonella / Salmonella choleraesuis / Bacteremia / Virulence plasmid / 毒力プラスミド / 菌血症 / 毒カプラスミド / Tyne III secretion system / vaccine … More / infectious diseases / virulence factors / III型分泌機構 / ワクチン / 感染症 / 病原因子 / invA mutant / Ca^<2+> influx / Phospholipase A_2 / Arachidonic acid / Smooth muscle cells / Salmonells Choleraresuis / Salmonella septicemia / チロシンキナーゼ阻害剤 / カルシウム阻害剤 / ホスフォリ-パーゼA_2 / サルモネラ症 / invA変異株 / 細胞内Ca^<2+>流入 / phospholipase A2 / アラキドン酸 / 平滑筋細胞 / Salmonella Choleraesuis / サルモネラ菌血症 / lmmano-Electron Microscopy / Virulance protein / Regulation of expression / Plasmid / Virulence / salmonella / 免疫電顕 / 発現 / 細胞局在性 / 精製 / 機能 / 免疫電子顕微鏡 / ビルレンス蛋白質 / 発現調節 / プラスミド / ビルレンス … More
Except Principal Investigator
Chk / Fyn / サルモネラ / Pyk2 / 緑膿菌 / 病原細菌 / SLO / 分子遺伝学 / 細胞侵入性 / 組換えDNA実験 / ビルレンス / 病原性 / 赤痢菌 / Plasmid / Pathogenic Bacteria / Gene Analysis / Molecular Genetics / Recombinant DNA Technology / Virulence gene / Pathogenicity / Pathogenic Bacteriology / 嫌気性菌 / ブローブ / ビブリオ / チフス菌 / コレラ菌 / 分子進化 / 遺伝的制御機構 / 毒素 / ピルレンス / クローン化 / 塩基配列 / 遺伝子 / 細菌 / プラスミド / 病原菌 / 遺伝子解析 / 分子遺伝学的研究 / ビルレンス遺伝子 / 病原細菌学 / Adhesion molecules / Vieulence factors / Endothelial cells / Bacterial invasion / Citekines / Salmonella infection / 接着分子 / ビルレンス因子 / 血管内皮細胞 / サイトカイン / サルモネラ感染症 / AIDS / Salmonella / Infection Immunity / Isoform / Tyrosine Kinase / マクロファージ分化 / エイズ / 感染免疫 / アイソフォーム / チロシンキナーゼ / PHICTX phage / virulence plasmid / Vibrio genome / Ipa protein / hemolysin / motility / collagenase / Two component regulatory system / ヘリコバクター・ピロリ / ボツリヌス毒素 / B.fragilis / 腸炎ビブリオ / P.gingivalis / 赤痢菌Ipa蛋白 / φCTXファージ / ビルレンスプラスミド / ビブリオゲノム / Ipaタンパク / 溶血毒 / 運動性 / コラゲナーゼ / 2成分制御系 / Electron energy loss spectroscopy / Pore-forming toxin / Immuno-electron microscopy / Lyposome / Negative staining / Hemolysis / Streptolysin 0 / 赤血球膜 / 超微細形態 / 電子分光型透過電顕 / 孔形成毒素 / 免疫電顕 / リポソーム / ネガティブ染色 / 電子分光顕微鏡 / 溶血機構 / ストレプトリジンO / molecular genetics / vaccine / cell invasion / recombinant DNA experiments / virulence / pathogenicity / Shigella flexneri / 免疫病理学 / 分子遺伝学的解析 / サル実験 / 赤痢 / 組換えDNA / ワクチン Less
  • Research Projects

    (10 results)
  • Research Products

    (27 results)
  • Co-Researchers

    (30 People)
  •  Functional analysis of Salmonella type III secretion system translocator protein SipC and application of vaccine developmentPrincipal Investigator

    • Principal Investigator
      DANBARA Hirofumi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Kitasato University
  •  Salmonella infection and proinflammatory responses of human vascular endothelial cells

    • Principal Investigator
      OKADA Nobuhiko
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Kitasato University
  •  Role of Tyrosine Kinase in Infection Immunity

    • Principal Investigator
      MORIKAWA Yuko
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      免疫の制御機構
    • Research Institution
      The Kitasato Institute
  •  Studies on molecular genetics of bacterial pathogenesis

    • Principal Investigator
      NAKAZAWA Teruko
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Yamaguchi University
  •  Enhancement of Ca^<2+>-influx and prostaglandin E_2accumulation in cultured pig vascular smooth muscle cells infected with Salmonella CholeraesuisPrincipal Investigator

    • Principal Investigator
      DANBARA Hirohumi
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Department of Microbiology School of Pharmaceutical Sciences Kitasato university
  •  Ultrastructural Analysis of Pore-Formation by Streptolysin 0

    • Principal Investigator
      SEKIYA Kachiko
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Kitasato University
  •  Cellular Localization, qurification, and function of plasmud-determinedrirulence proteins of SalmonellaPrincipal Investigator

    • Principal Investigator
      DANBARA Hirofumi
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      KITASATO,University
  •  Developement of live attenuated anti-Shigella vaccine based on molecular pathogenesis studies

    • Principal Investigator
      YOSHIKAWA Masanosuke
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      細菌学
    • Research Institution
      The University of Tokyo
  •  Correlation between infection mechanisms and virulence plasmid of Salmonella choleraesuisPrincipal Investigator

    • Principal Investigator
      DANBARA Hirofumi
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      細菌学
    • Research Institution
      The Kitasato Institute
  •  Molecular Genetic Studies on Bacterial Pathogenicity

    • Principal Investigator
      YOSHIKAWA Masanosuke
    • Project Period (FY)
      1987 – 1989
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      細菌学
    • Research Institution
      The University of Tokyo

All 2008 2007 2006

All Journal Article Presentation

  • [Journal Article] DsbA directs efficient expression of outer membrane secretin EscC of the enterop athogenic Escherichia coli type III secretion apparatus.2008

    • Author(s)
      Miki T, Okada N., Kim Y-S., Abe A., and Danbara H.
    • Journal Title

      Microb.Pathog. 44

      Pages: 151-158

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Journal Article] DsbA directs efficient expression of outer membrane secretin EscC of the enteropathogenic Escherichia coli type III secretion apparatus2008

    • Author(s)
      Miki T., N Okada, Y-S Kim, A Abe, and H Danbara.
    • Journal Title

      Microb.Pathog 44

      Pages: 151-158

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Journal Article] DsbA directs efficient expression of outer membrane secretin EscC of the enteropathogenic Escherichia coli type III secretion apparatus2008

    • Author(s)
      Miki, T, Okada, N, Kim, Y-S, Abe, A, Danbara, H
    • Journal Title

      Microb Pathog 44

      Pages: 151-158

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Journal Article] Identification of amino acid residues of Salmonella SlyA that are critical for transcriptional regulation.2007

    • Author(s)
      Okada, N., Y.Oi, M.Takeda-Shitaka, K.Kanou, H.Umeyama, T.Haneda, T.Miki, S.Hosoya, H.Danbara
    • Journal Title

      Microbiology 153

      Pages: 548-560

    • Data Source
      KAKENHI-PROJECT-18590435
  • [Journal Article] Identification of amino acid residues of Salmonella SlyA that are critical for transcriptional regulation2007

    • Author(s)
      Okada, N., Y. Oi, M.Takeda-Shitaka, K. Kanou, H. Umeyama, T. Haneda, T. Miki, S. Hosoya and H. Danbara.
    • Journal Title

      Microbiology 153

      Pages: 548-560

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Journal Article] Identification of amino acid residues of Salmonella S1yA that are critical for transcriptional regulation2007

    • Author(s)
      Okada, N, Oi, Y, Takeda-Shitaka, M, Kanou, K, Umeyama, H, Haneda, T, Miki, T, Hosoya, S, Danbara, H
    • Journal Title

      Microbiology 153

      Pages: 548-560

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Presentation] Salmonella pathogenicity island 2 にコードされるSTMI410の機能解析2008

    • Author(s)
      山下 藍、三木 剛志、吉田 雪絵、岡田 信彦、檀原 宏文
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2008-03-24
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Presentation] Secretion of Salmonella virulence plasmid factor SpvC by the type III secretion system encoded by Salmonella pathogenicity island 12008

    • Author(s)
      Shimizu, M, N, Okada, H, Danbara
    • Organizer
      The 81th annual meeting of the Japanese Society for Microbiology
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-03-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Presentation] Salrvsonellaマクロファージ内増殖に関わるビルレンス因子の同定とその機能解析2008

    • Author(s)
      吉田 雪絵、岡田 信彦、檀原 宏文
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都市、京都国際会議場
    • Year and Date
      2008-03-24
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Presentation] Salmonella pathogenicity island2にコードされるSTM1410の機能解析2008

    • Author(s)
      山下 藍、三木 剛志、吉田 雪絵、岡田 信彦、檀原 宏文
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都市、京都国際会議場
    • Year and Date
      2008-03-24
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Presentation] Functional analysis of STM1410 encoded by Salmonella pathogenicity island 22008

    • Author(s)
      Yamasita, A, Miki, T, Y, Yoshida, N, Okada, H, Danbara
    • Organizer
      The 81th annual meeting of the Japanese Society for Microbiology
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-03-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Presentation] III型分泌機構を介したSalmonellaプラスミドビルレンスSpvCの分泌2008

    • Author(s)
      清水 啓道、岡田 信彦、檀原 宏文
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都市、京都国際会議場
    • Year and Date
      2008-03-24
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Presentation] III型分泌機構を介したSalmonellaプラスミドビルレンスSpvCの分泌2008

    • Author(s)
      清水 啓道、岡田 信彦、檀原 宏文
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2008-03-24
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Presentation] Salmonellaマクロファージ内増殖に関わるビルレンス因子の同定とその機能解析2008

    • Author(s)
      吉田 雪絵、岡田 信彦、檀原 宏文
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2008-03-24
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Presentation] Identification and characterization of Salmonella virulence factors required for bacterial growth in macrophage2008

    • Author(s)
      Yoshida, Y, N, Okada, H, Danbara
    • Organizer
      The 81th annual meeting of the Japanese Society for Microbiology
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-03-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Presentation] Chromobacterium violaceumの病原性発現における血型分泌機構の役割2007

    • Author(s)
      井口 美礼、三木 剛志、岡田 信彦、檀原 宏文
    • Organizer
      第20回遺伝子とその周辺研究会
    • Place of Presentation
      大船渡市
    • Year and Date
      2007-08-09
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Presentation] Identification and characterization of Salmonella virulence factors required for bacterial growth in Macrophage2007

    • Author(s)
      Yoshida, Y, Haneda, T, N, Okada, Y, Kodera, M, Ohishi, T, Maeda, H, Danbara
    • Organizer
      The 20th Bioscience forum in Kitasato university
    • Place of Presentation
      Ofunato, Iwate
    • Year and Date
      2007-08-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Presentation] Salmonellaマクロファージ内増殖に関わるビルレンス因子あ同定とその機能解析2007

    • Author(s)
      吉田 雪絵、羽田 健、岡田 信彦、小寺 義男、大石 正道、前田 忠計、檀原 宏文
    • Organizer
      第20回遺伝子とその周辺研究会
    • Place of Presentation
      大船渡市
    • Year and Date
      2007-08-09
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Presentation] Regulation of expression of the type III secretion system encoded by Salmonella pathogenicity island 22007

    • Author(s)
      Miki, T, N, Okada, H, Danbara
    • Organizer
      The 89th annual meeting of the Japanese Society for Microbiology in Kanto branch
    • Place of Presentation
      Ikaho, Gunnma
    • Year and Date
      2007-11-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Presentation] オートファジーによるSalmonella染防御機構の解析2007

    • Author(s)
      福島 直子、岡田 信彦、菊池 雄士、檀原 宏文
    • Organizer
      第20回遺伝子とその周辺研究会
    • Place of Presentation
      大船渡市
    • Year and Date
      2007-08-09
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Presentation] Autophagy controls by Salmonella infection via innate and acquired immune pathways2007

    • Author(s)
      Fukushima, N, N, Okada, Y, Kikuchi, H, Danbara
    • Organizer
      The 20th Bioscience forum in Kitasato university
    • Place of Presentation
      Ofunato, Iwate
    • Year and Date
      2007-08-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Presentation] Role of the type III secretion systems in pathogenesis of Chromobacterium violaceum2007

    • Author(s)
      Iguchi, M, T, Miki, N, Okada, H, Danbara
    • Organizer
      The 20th Bioscience forum in Kitasato university
    • Place of Presentation
      Ofunato, Iwate
    • Year and Date
      2007-08-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Presentation] Mapping of Salmonella cell proteins by agarose 2D-electrophoresis2006

    • Author(s)
      Haneda, T, M, Sugimoto, N, Okada, S, Shimizu, N, Nameki, Y, Kodera, M, Ohishi, T, Maeda, H, Danbara
    • Organizer
      The 4th Clinical Proteomics Forum
    • Place of Presentation
      Sagamihara, Kanagawa
    • Year and Date
      2006-08-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Presentation] サルモネラのアガロース2次元電気泳動マップの作成2006

    • Author(s)
      羽田 健、杉本 茉莉子、岡田 信彦、清水 聡美、行木 乃芙絵、小寺 義男、大石 正道、前田 忠計、檀原 宏文
    • Organizer
      第4回疾患プロテオーム研究会
    • Place of Presentation
      相模原市、北里大学相模原キヤンパス
    • Year and Date
      2006-08-04
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Presentation] Salmonella pathigenicity island2タイプIII分泌装置の機能発現調節2006

    • Author(s)
      三木 剛志、岡田 信彦、檀原 宏文
    • Organizer
      第89回日本細菌学会関東支部総会
    • Place of Presentation
      群馬県伊香保町
    • Year and Date
      2006-11-16
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Presentation] Salmonella pathigenicity island4の機能解析2006

    • Author(s)
      細野 正人、羽田 健、岡田 信彦、檀原 宏文
    • Organizer
      第19回遺伝子とその周辺研究会
    • Place of Presentation
      相模原市、北里大学相模原キヤンパス
    • Year and Date
      2006-08-02
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590435
  • [Presentation] Functional analysis of Salmonella pathogenicity 42006

    • Author(s)
      Hosono, M, T, Haneda, N, Okada, H, Danbara
    • Organizer
      The 19th Bioscience Forum in Kitasato university
    • Place of Presentation
      Sagamihara, Kanagawa
    • Year and Date
      2006-08-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590435
  • 1.  SEKIYA Kachuko (30050579)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  SASAKAWA Chihiro (70114494)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  OKADA Nobuhiko (80194364)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 27 results
  • 4.  KIKUCHI Yuji (60262078)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  YOSHIKAWA Masanosuke (80012714)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  NAGAI Masaaki (10198294)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  TERAWAKI Yoshiro (10014333)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  MATSUI Hidenori (30219373)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  NARIUCHI Hideo (10012741)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  SHIMADA Hiroyuki (60113487)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  TAKASAKA Masao (80072924)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  ABE Akio (50184205)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  ENDOH Masahiko (60104519)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  FUTAESAKU Yutaka (50014197)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  NAKAZAWA Teruko (40053053)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  HAYASHI Hideo (40033203)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  OGUMA Keiji (00002262)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  KAWAKAMI Takatoshi (40280622)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  MORIKAWA Yuko (20191017)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  TSUKAMOTO Toshiyuki (10236862)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  KATAGIRI Takuya (70126100)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  HANEDA Takeshi (00348591)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 23.  YAMAMOTO Tatsuo (80095843)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  EZAKI Takayuki (90151977)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  KAWAHARA Kazuyoshi (20195126)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  MORIGUCHI Ryozo (30101299)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  渡辺 治雄 (70142130)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  岡村 登 (00111592)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  橋本 一 (90008235)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  吉村 文信 (50001962)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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