YAMASHITA Keisuke 山下敬介

Researcher Number	40166666
Other IDs
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Affiliation (based on the past Project Information) *help	2007: Hiroshima University, Graduate School of Biomedical Sciences, Associate Professor 2006: 広島大学, 医歯薬学総合研究科, 助教授 2002 – 2003: Hiroshima University, Graduate School of Biomedical Sciences, Associate Professor, 大学院・医歯薬学総合研究科, 助教授 1997 – 2001: 広島大学, 医学部, 助教授 1995 – 1996: 広島大学, 医学部, 講師 1986 – 1988: Assist. Prof, Osaka Univ. Med. Sch., 医学部, 助手
Review Section/Research Field	Principal Investigator General anatomy (including Histology/Embryology) / Science and Engineering Except Principal Investigator General anatomy (including Histology/Embryology) / Respiratory organ internal medicine / 環境影響評価(含放射線生物学)
Keywords	Principal Investigator 発生毒性 / ダイオキシン / 口蓋裂 / 病的発生過程 / Mice / Gene targeting / 転写調節 / 受容体 / 発生学 / Cerebellum … More / Immunotoxicity / Embryotoxicity / Reproductive toxicity / Recombinant DNA / Dioxin / 精巣 / 内分泌かく乱 / 免疫毒性 / 行動異常 / 小脳発生 / 肝臓解毒酵素誘導 / 生殖毒性 / 遺伝子組み換えマウス / Development / Pathogenesis / Cleft palate / Homologous recombination / Dioxins / Teratogenesis / 受容体欠損 / 遺伝子操作 / 病因 / マウス / 遺伝子欠損動物 / 相同組み換え / 奇形発生 / 毒性学 / 発生・分化 / 解剖学 / 遺伝子改変マウス / 転写調節機構 / ダイオキシン受容体 / 微細形態 / 細胞死 / 細胞動態 / 水腎症 … More Except Principal Investigator ダイオキシン / 催奇形性 / 発生毒性 / アロマターゼ / メロメリアマウス / ノックアウトマウス / 水腎症 / 口蓋裂 / Ah受容体 / 皮膚紋理 / レチノイン酸 / Electron microscopy / Immunocytochemistry / Testis / Ovary / Adrenal cortex / Steroid hormones / ステロイド3β水酸基脱水素酵素 / カルスペクチン / 21水酸化酵素 / ステロイド17β水酸基脱水素酵素 / 腎髄質間質細胞 / ATP合成酵素 / エストロゲン / 電子顕微鏡 / 免疫組織化学 / 精巣 / 卵巣 / 副腎皮質 / ステロイドホルモン / Kupffer cells / cell polarity / thyroid / multigranular exocytosis / phophorlipase <A_2> activator / Anterior Pituitary / 甲状腺濾胞上皮細胞の極性 / 側鎖切断酵素 / 表層粘液細胞 / 多果粒性開口分泌 / フォスフォリパーゼ【A_2】 / ラテックス粒子 / クップエル細胞 / 甲状腺 / カルシウム / 下垂体前葉 / 貪食 / 分泌 / Chemoattractant / Neutrophil / Integrin / Osteopontin / Pulmonary Fibrosis / 重合 / トランスグルタミナーゼ / 走化因子 / 好中球 / インテグリン / オステオポンチン / 肺線維症 / Glucocorticoid / Endocrine disrupters / Adrenal cortex hormone / Dioxin / 糖質コルチコイド / 内分泌撹乱化学物質 / 副腎皮質ホルモン / hairpin tail mice / trisomy 14 mice / trisomy 16 mice / meromelia mice / phenotypes / Ahr gene / knock-out mice / mutant mice / 四肢奇形 / 脊椎後彎 / アリール炭化水素受容体 / ヘアピン尾マウス / トリソミー14マウス / トリソミー16マウス / 表現型 / Ahr遺伝子 / ミュータント系マウス / retinoic acid / apical ectodermal ridge / dorso-ventral axis / Wnt-7a gene / En-1 gene / meromelia mouse / pad / limb morphogenesis / Fg遺伝子 / Wnt遺伝子 / トリソミ-16マウス / Ets2遺伝子 / Shh遺伝子 / Fgf遺伝子 / En遺伝子 / ハンマートウマウス / 外胚葉性頂提 / 外胚葉性頂堤 / 背腹軸 / Wnt-7a遺伝子 / En-1遺伝子 / パッド / 肢形態形成 / 情報伝達系 / ダイオキシン受容体 / 生殖毒性 / 免疫毒性 / 掌蹠パッド / 口蓋ヒダ / PCB Less

Research Projects
(14 results)
Co-Researchers
(18 People)

Investigation of mechanism of pulmonary fibrosis focusing on post-translational modification of osteopontin and its receptor change
- Principal Investigator
  
  YOKOSAKI Yasuyuki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hiroshima University
ダイオキシンの生体毒性発現機構の解明Principal Investigator
- Principal Investigator
  
  山下敬介
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Hiroshima University
Effect of Dioxin and Endocrine disrupters on Adrenal Hormone
- Principal Investigator
  
  SUGIHARA Kazumi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Institution
  Hiroshima University
ダイオキシン類化合物の生体毒性機構に関する研究
- Principal Investigator
  
  菊池英明
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Tohoku University
Anatomical analyses of phenotypes in mutant mice
- Principal Investigator
  
  YASUDA Mineo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Hiroshima University
Pathogenesis of the toxicity of dioxin in the mouse.Principal Investigator
- Principal Investigator
  
  YAMASHITA Keisuke
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Institution
  Hiroshima University
ダイオキシンの発生毒性発現機序の分子生物学的・細胞化学的解析
- Principal Investigator
  
  安田峯生
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hiroshima University
Molecular Mechanism of Developmental Toxicity Caused by Dioxin in Mice.Principal Investigator
- Principal Investigator
  
  YAMASHITA Keisuke
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  HIROSHIMA UNIVERSITY
ダイオキシンによるマウス発生毒性発現機序の分子生物学的・細胞化学的解析
- Principal Investigator
  
  安田峯生
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hiroshima University
ダイオキシンによるマウス胎仔の水腎・口蓋裂誘発機序の微細形態学的・細胞化学的解析Principal Investigator
- Principal Investigator
  
  山下敬介
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Hiroshima University
Embryological and teratological analyzes of genes acting in limb morphogenesis
- Principal Investigator
  
  YASUDA Mineo
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  HIROSHIMA UNIVERSITY
ダイオキシン類の発生毒性検出のための新指標
- Principal Investigator
  
  YASUDA Mineo
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hiroshima University
Immunocytochemical study on the mechanism of steroid hormone biosynthesis.
- Principal Investigator
  
  ISHIMURA Kazunori
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Osaka University Medical School
Fine structural and cytochemical aspects on the secretory and endocytotic activities of cells.
- Principal Investigator
  
  FUJITA Hisao
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Osaka University

1. YASUDA Mineo (50079688)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. MATSUI Kohji (80183945)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 菊池英明 (60006111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 青木康展 (20159297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 松居靖久 (40241575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 福本学 (60156809)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 十川和博 (80175421)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SUGIHARA Kazumi (20271067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KITAMURA Shigeyuki (40136057)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. FUJIMOTO Nariaki (40243612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. OHTA Shigeru (60160503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YOKOSAKI Yasuyuki (80210607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NAKATA Koh (80207802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MORIMOTO Yasuo (30258628)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HIGASHIKAWA Fumiko (70346534)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. FUJITA Hisao (50033949)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. BAN Tadanobu (70028596)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. ISHIMURA Kazunori (90112185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YAMASHITA Keisuke 山下 敬介

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ダイオキシンの生体毒性発現機構の解明Principal Investigator

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Pathogenesis of the toxicity of dioxin in the mouse.Principal Investigator

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Molecular Mechanism of Developmental Toxicity Caused by Dioxin in Mice.Principal Investigator

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ダイオキシンによるマウス胎仔の水腎・口蓋裂誘発機序の微細形態学的・細胞化学的解析Principal Investigator

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YAMASHITA Keisuke 山下敬介