Okamoto Yoshitaka 岡本美孝

… Alternative Names

OKAMOTO Yoshitaka 岡本美孝

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Researcher Number	40169157
Other IDs
External Links
Affiliation (Current)	2025: 千葉大学, 大学院医学研究院, 名誉教授
Affiliation (based on the past Project Information) *help	2016 – 2018: 千葉大学, 大学院医学研究院, 教授 2016: 千葉大学, 医学系研究科, 教授 2012 – 2015: 千葉大学, 医学(系)研究科(研究院), 教授 2014: 千葉大学, 医学研究科, 教授 2014: 千葉大学, 大学院医学研究院, 教授 … More 2011: 千葉大学, 医学系研究科, 教授 2010 – 2011: 千葉大学, 医学, 教授 2007 – 2011: Chiba University, Graduate School of Medicine, Department of Otolaryngology, Professor 2006: Chiba University, Graduate School of Medicine, Professor, 大学院医学研究院, 教授 2002 – 2005: Chiba University, Graduate School of Medicine, Professor, 大学院・医学研究院, 教授 1996 – 2001: Yamanashi Medical University Professor, 医学部, 教授 1993 – 1995: 秋田大学, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Otorhinolaryngology / Otorhinolaryngology Except Principal Investigator Otorhinolaryngology / Otorhinolaryngology / Production engineering/Processing studies / アレルギー
Keywords	Principal Investigator nasal allergy / ウイルス / NKT細胞 / 鼻アレルギー / virus / RSウイルス / サイトカイン / 頭頸部癌 / Th2細胞 / Th2サイトカイン … More / アレルギー性鼻炎 / upper respiratory infection / Th2 cell / Th1 cell / cedar pollinosis / allergic rhintis / 鼻粘膜過敏性 / 気道感染 / 上気道感染 / Th1細胞 / スギ花粉症 / polymerase chain reaction / tissve culture / bacteria / Acute otitis media / 中耳炎動物モデル / 核酸増殖法 / ウイルス中和抗体 / 肺炎球菌 / 核酸増幅 / 組織培養 / 気道アレルギー / 細菌 / 急性中耳炎 / transgenic mice / recombinant vacvina virus / respiratory syncytial virus / Th2 cytokine / Th1 cytokine / 感染実験 / ワクチニアウイルス / 鼻アレルギーモデルマウス / IL-10 / 鼻腔免疫 / 抗体投与 / 鼻腔粘膜 / 腸管免疫 / 受動免疫 / トランスジェニックマウス / Th1サイトカイン / chronic sinusitis / cell adhesion molecule / cytokine / nasal mucosa / F糖蛋白 / G糖蛋白 / マウス / トシル酸スプラタスト / ヒト鼻アレルギー / ハウスダスト / 慢性炎症 / アレルギー / 細胞接着分子 / 鼻・副鼻腔 / アジュバンド療法 / 先進医療 / アジュバント療法 / 細胞障害性T細胞 / 悪性黒色腫 / 扁平上皮癌 / 癌免疫療法 / 抗原提示細胞 / 粘膜投与 / 免疫療法 / Th2 細胞 / Th2 サイトカイン / NKT 細胞 / 好酸球性副鼻腔炎 … More Except Principal Investigator サイトカイン / メタマテリアル・表面プラズモン / IgE / IL-12 / toll like receptor / Th2 / IgA / NALT / RSウイルス / トランスレーショナル・リサーチ / mesothelin / メソテリン / 標的分子 / 免疫療法 / 唾液腺癌 / キメラ抗原受容体 / ナノマイクロ加工 / 鼻アレルギー / アレルギー / 光線力学治療 / アレルギー性鼻炎 / アミノレブリン酸 / 光線力学的治療 / メタマテラル・表面プラズモン / NKT細胞 / 免疫細胞療法 / がん免疫療法 / 唾液腺がん / がん免疫 / EXiLE / 舌下免疫療法 / ルシフェラーゼ / バイオマーカー / IgG / EXiLE法 / アレルゲン舌下免疫療法 / TNF-alpha / delta T cell / gamma / peptidoglycan / lipopolysaccharide / intestinal microflora / cord blood / TLR2 / CD14 / TLR4 / 自然免疫 / プロバイオティクス / TNF-α / γδT細胞 / ペプチドグリカン / リポポリサッカライド / 腸内細菌 / 臍帯血 / chemokine / cytokine / eosinophil / genotype analyses / preventive medicine / nasal mucosal hyperresponsiveness / IL-4受容体α鎖 / 遺伝子多型 / スギ花粉症 / ケモカイン / 好酸球 / 遺伝子多型解析 / 予防医学 / 鼻過敏症 / RS virus infection / Th l / cell transfer / CD4+T cell / Mast cell / Eosinophil infiltration / Nasal hypersensitivity / Nasal allergy / アレルギーモデルマウス / RSウイルス感染 / Th1 / 細胞移入 / CD4陽性T細胞 / 肥満細胞 / 好酸球浸潤 / 鼻粘膜知覚過敏性 / RS virue / Streptococcus pneumoniae / Haemophilus influenzae / Mucosal immune system / vaccine / Intranasal immunization / P6 / CD4^+T細胞 / マウス / 中耳粘膜 / 鼻粘膜 / 肺炎球菌 / インフルエンザ菌 / 経鼻免疫 / ワクチン / goblet cell / mucus / airway secretion / nitric oxide / 鼻粘膜上皮杯細胞 / 鼻粘膜上皮 / 鼻汁分泌 / 杯細胞 / 一酸化窒素 / Mucosal immunity / Respiratory syncytial virus / Adhesion molecule / Cytokine / Otitis media effusion / PCR法 / 腸管免疫 / 細胞接着分子 / 滲出性中耳炎 / 癌免疫 / マタマテリアル・表面プラズモン / 表面プラズモン / メタマテリアル / ナノ・マイクロ加工 / 記憶免疫 / Th2細胞 / 花粉症 / Th2 細胞 / メモリーT細胞 / 免疫記憶 / 免疫学 / アレルギー・ぜんそく / ぜんそく / 嗅上皮 / BDNF / アデノウイルスベクター Less

Study of the mechanism and therapeutic biomarkers for sublingual immunotherapy by using the EXiLE method
- Principal Investigator
  
  Nakamura Ryosuke
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  National Institute of Health Sciences
Adoptive Immunotherapy using the Lymphocytes transduced with Chmeric Antigen Receptor against Salivary Gland Tumor
- Principal Investigator
  
  KUNII Naoki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Development of photodynamic therapy for the allergic rhinitis
- Principal Investigator
  
  SUZUKI TAKESHI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Plasmonic nanostructures realizing miniaturized infrared spectrometric image-array-sensor for endoscopy
- Principal Investigator
  
  Delaunay Jean-Jacques
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Production engineering/Processing studies
- Research Institution
  The University of Tokyo
light confinement in plasmonic nanocavities for use as biosensor
- Principal Investigator
  
  DELAUNAY Jean-Jacques
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Production engineering/Processing studies
- Research Institution
  The University of Tokyo
Adoptive Immunotherapy using the Lymphocytes transduced with Chimeric Antigen Receptor against Salivary Gland Tumor
- Principal Investigator
  
  KUNII Naoki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Development of adjuvant therapy for head and neck cancer by activation of NKT cells via nasal mucosaPrincipal Investigator
- Principal Investigator
  
  Okamoto Yoshitaka
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Breath test sensors for disease screening
- Principal Investigator
  
  J-J Delaunay
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Production engineering/Processing studies
- Research Institution
  The University of Tokyo
Adjuvant cellular immnunotherapy for head and neck cancerPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Yoshitaka
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Role of NKT cells in the eosinophilic diseases in upper respiratory tract and approachfor a new treatmentPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Yoshitaka
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Seasonal changes in antigen-specific T-helper clone sizes and their memory functions in patients with Japanese cedar pollinosis
- Principal Investigator
  
  HORIGUCHI Shigetoshi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Role of infectious diseases in allergic rhinitisPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Yoshitaka
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Function of innate-immune cells in cord blood and development of allergy
- Principal Investigator
  
  SHIMOJO Naoki
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  アレルギー
- Research Institution
  Chiba University
アデノウイルスベクターを用いた神経伸長因子遺伝子導入による鼻粘膜嗅上皮の再生
- Principal Investigator
  
  SUZUKI Homare
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Aiming toward effective preventive medicine against Japanese cedar pollinosis : -----Epidemiology, patient investigation, and integrated research including genotype analyses-
- Principal Investigator
  
  TERADA Nobuhisa
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Influence of viral infection on the devefepmeat of acute otitis media and approach for treatmentPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Yoshitaka
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  CHIBA UNIVERSITY
  山梨医科大学
The mechanism of development of nasal hypersensitivity: Role of T cell and approach to treatment
- Principal Investigator
  
  MATSUZAKI Zensei
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Yamanashi Medical University
The mucosal immune system of the upper respiratory tract and development of nasal vaccine for upper respiratory tract infection
- Principal Investigator
  
  MOGI Goro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Oita Medical University
The role of cytokines in varal infection and in allergy in the respiratory tract was evaluated.Principal Investigator
- Principal Investigator
  
  OKAMOTO Yoshitaka
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Yamanashi Medical University
The effect of NO in the sesretion from nasal epithelial goblet cells.
- Principal Investigator
  
  KAMIJO Atsushi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Yamanashi Medical University
Expression of cytokines and cell adhesion molecules in nasal inflammatory diseases.Principal Investigator
- Principal Investigator
  
  OKAMOTO Yoshitaka
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Yamanashi Medical University
  Akita University
The study of the pathogenesis of otitis media with effusion and the role of viral infection.
- Principal Investigator
  
  ITO Eiko, SARASHINA Norio
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  AKITA UNIVERSITY

[Book] アレルギー疾患のすべて2016
- Author(s)
  岡本美孝
- Total Pages
  367
- Publisher
  日本医師会
- Data Source
  KAKENHI-PROJECT-16H05483
[Journal Article] Pathogenicity of memory Th2 cells is linked to stage of allergic rhinitis2018
- Author(s)
  Iinuma T.、Okamoto Y.、Morimoto Y.、Arai T.、Sakurai T.、Yonekura S.、Sakurai D.、Hirahara K.、Nakayama T.
- Journal Title
  
  Allergy
  
  Volume: 73 Issue: 2 Pages: 479-489
- DOI
  10.1111/all.13295
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08876, KAKENHI-PROJECT-16H05483
[Journal Article] An analysis of factors related to the effect of sublingual immunotherapy on Japanese cedar pollen induced allergic rhinitis2018
- Author(s)
  Yonekura S, Okamoto Y, Sakurai D, Okubo K, Gotoh M, Kaneko S, Konno A.
- Journal Title
  
  Allergol. Int.
  
  Volume: 67 Issue: 2 Pages: 201-208
- DOI
  10.1016/j.alit.2017.07.005
- NAID
  130006721780
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10778, KAKENHI-PROJECT-16H05483
[Journal Article] Identification of specifically reduced Th2 cell subsets in allergic rhinitis patients after sublingual immunotherapy2018
- Author(s)
  1.Ihara F, Saurai D, Yonekura S, Iinuma T, Matsuura A, Morimoto Y, Arai T, Suzuki S,　Katayama K, Nakayama T, Okamoto Y
- Journal Title
  
  Allergy
  
  Volume: 73 Issue: 9 Pages: 1823-1832
- DOI
  10.1111/all.13436
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05483
[Journal Article] Immunosuppressive property of submandibular lymph nodes in patients with head and neck tumors: differential distribution of regulatory T cells2018
- Author(s)
  Sakurai D, Uchida R, Ihara F, Kunii N, Nakagawa T, Chazono H, Hanazawa T, Motohashi S, Okamoto Y
- Journal Title
  
  BMC Research Notes
  
  Volume: 11 Issue: 1 Pages: 479-479
- DOI
  10.1186/s13104-018-3587-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05483, KAKENHI-PROJECT-17K11376, KAKENHI-PROJECT-17K16892, KAKENHI-PROJECT-18H02892
[Journal Article] Deep sequencing-based microRNA expression signatures in head and neck squamous cell carcinoma: dual strands of pre-miR-150 as antitumor miRNAs.2017
- Author(s)
  Koshizuka K, Hanazawa T, Fukumoto I, Kikkawa N, Okamoto Y, Seki N.
- Journal Title
  
  Oncotarget
  
  Volume: 印刷中 Issue: 18 Pages: 30288-30304
- DOI
  10.18632/oncotarget.16327
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-16K11224, KAKENHI-PROJECT-17K11375, KAKENHI-PROJECT-17K16893, KAKENHI-PROJECT-15K10801, KAKENHI-PROJECT-16K20229
[Journal Article] Definitive carbon-ion radiotherapy for locally advanced parotid gland carcinomas.2017
- Author(s)
  Koto M, Hasegawa A, Takagi R, Ikawa H, Naganawa K, Mizoe JE, Jingu K, Tsujii H, Tsuji H, Kamada T, Okamoto Y.
- Journal Title
  
  Head Neck.
  
  Volume: 39 Issue: 4 Pages: 724-729
- DOI
  10.1002/hed.24671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249081
[Journal Article] House dust mite sublingual tablet is effective and safe in patients with allergic rhinitis.2017
- Author(s)
  Okamoto Y, Fujieda S, Okano M, Yoshida Y, Kakudo S, Masuyama K.
- Journal Title
  
  Allergy
  
  Volume: 72 Issue: 3 Pages: 435-443
- DOI
  10.1111/all.12996
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05483, KAKENHI-PROJECT-26293368, KAKENHI-PROJECT-15H04987
[Journal Article] Dual-receptor (EGFR and c-MET) inhibition by tumor-suppressive miR-1 and miR-206 in head and neck squamous cell carcinoma.2017
- Author(s)
  Koshizuka K, Hanazawa T, Fukumoto I, Kikkawa N, Matsushita R, Mataki H, Mizuno K, Okamoto Y, Seki N.
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 62 Issue: 1 Pages: 113-121
- DOI
  10.1038/jhg.2016.47
- NAID
  40021036343
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-26462596, KAKENHI-PROJECT-15K10800, KAKENHI-PROJECT-15K10801, KAKENHI-PROJECT-16K11224
[Journal Article] The microRNA signatures: aberrantly expressed microRNAs in head and neck squamous cell carcinoma.2017
- Author(s)
  Keiichi Koshizuka, Toyoyuki Hanazawa, Ichiro Fukumoto, Naoko Kikkawa, Yoshitaka Okamoto, Naohiko Seki.
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 62 Issue: 1 Pages: 3-13
- DOI
  10.1038/jhg.2016.105
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-15K10800
[Journal Article] Invariant NKT cells are resistant to circulating CD15(+) myeloid-derived suppressor cells in patients with head and neck cancer.2016
- Author(s)
  Horinaka A, Sakurai D, Ihara F, Makita Y, Kunii N, Motohashi S, Nakayama T, Okamoto Y.
- Journal Title
  
  Cancer Sci.
  
  Volume: 107 Issue: 3 Pages: 207-16
- DOI
  10.1111/cas.12866
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-15K20181
[Journal Article] Carbon ion radiotherapy for locally advanced squamous cell carcinoma of the external auditory canal and middle ear.2016
- Author(s)
  Koto M, Hasegawa A, Takagi R, Sasahara G, Ikawa H, Mizoe JE, Jingu K, Tsujii H, Kamada T, Okamoto Y
- Journal Title
  
  Head Neck.
  
  Volume: 38(4) Issue: 4 Pages: 512-6
- DOI
  10.1002/hed.23905
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249081
[Journal Article] Tumor-suppressive microRNAs (miR-26a/b, miR-29a/b/c and miR-218) concertedly suppressed metastasis-promoting LOXL2 in head and neck squamous cell carcinoma2016
- Author(s)
  Ichiro Fukumoto, Naoko Kikkawa, Ryosuke Matsushita, Mayuko Kato, Akira Kurozumi, Rika Nishikawa, Yusuke Goto, Keiichi Koshizuka, Toyoyuki Hanazawa, Hideki Enokida, Masayuki Nakagawa, Yoshitaka Okamoto, Naohiko Seki
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 61(2) Issue: 2 Pages: 109-118
- DOI
  10.1038/jhg.2015.120
- NAID
  40020742209
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10800, KAKENHI-PROJECT-15K10801, KAKENHI-PROJECT-25462676, KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-26462596
[Journal Article] Three Cases of Neck Swelling after FNAC (fine-needle aspiration cytology)2016
- Author(s)
  大塚雄一郎, 根本俊光, 國井直樹, 花澤豊行, 岡本美孝
- Journal Title
  
  Nippon Jibiinkoka Gakkai Kaiho
  
  Volume: 119 Issue: 9 Pages: 1225-1230
- DOI
  10.3950/jibiinkoka.119.1225
- NAID
  130005420700
- ISSN
  0030-6622, 1883-0854
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K20181
[Journal Article] Evaluation of the safety and efficacy of carbon ion radiotherapy for locally advanced adenoid cystic carcinoma of the tongue base.2016
- Author(s)
  Koto M, Hasegawa A, Takagi R, Ikawa H, Naganawa K, Mizoe JE, Jingu K, Tsujii H, Tsuji H, Kamada T, Okamoto Y
- Journal Title
  
  Head Neck.
  
  Volume: 印刷中 Issue: S1
- DOI
  10.1002/hed.24397
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-26860970
[Journal Article] Basal cell adenoma of the parotid gland; MR features and differentiation from pleomorphic adenoma.2016
- Author(s)
  Mukai H, Motoori K, Horikoshi T, Takishima H, Nagai Y, Okamoto Y, Uno T.
- Journal Title
  
  Dentomaxillofac Radiol.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249081
[Journal Article] Long-term outcomes after carbon-ion radiotherapy for oral mucosal malignant melanoma.2016
- Author(s)
  Nakagawa K, Koto M, Takagi R, Hasegawa A, Ikawa H, Schimozato K, Kamada T, Okamoto Y.
- Journal Title
  
  Journal of Medical Case Reports
  
  Volume: 10：284 Pages: 1-4
- NAID
  130007397897
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249081
[Journal Article] Different Results of IgE Binding- and Crosslinking-Based Allergy Tests Caused by Allergen Immobilization2016
- Author(s)
  Okamoto-Uchida Y, Nakamura R, Matsuzawa Y, Soma M, Kawakami H, Ishii-Watabe A, Nishimaki-Mogami T, Teshima R, Saito Y.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 39 Issue: 10 Pages: 1662-1666
- DOI
  10.1248/bpb.b16-00389
- NAID
  130005598496
- ISSN
  0918-6158, 1347-5215
- URL
  https://pure.teikyo.jp/en/publications/6abb146a-da62-491b-b3e9-a4e794d6f491
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05483, KAKENHI-PROJECT-15K19168
[Journal Article] Th2 cells in health and disease.2016
- Author(s)
  Nakayama T, Hirahara K, Onodera A, Endo Y, Hosokawa H, Shinoda K, Tumes DJ, Okamoto Y.
- Journal Title
  
  Annu Rev Immunol.
  
  Volume: 35 Issue: 1 Pages: 53-84
- DOI
  10.1146/annurev-immunol-051116-052350
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05483, KAKENHI-PROJECT-17K08876, KAKENHI-PUBLICLY-16H01352, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-16H06224, KAKENHI-PROJECT-15K08522
[Journal Article] A Case of Oropharyngeal Squamous Cell Carcinoma who Developed Sigmoid Colon Perforation after Cetuximab Treatment2016
- Author(s)
  浜崎佐和子, 國井直樹, 蒔田勇治, 有本昇平, 木谷令, 鈴木猛司, 山崎一樹, 米倉修二, 茶薗英明, 櫻井大樹, 花澤豊行, 岡本美孝
- Journal Title
  
  Practica Oto-Rhino-Laryngologica
  
  Volume: 109 Issue: 11 Pages: 803-808
- DOI
  10.5631/jibirin.109.803
- NAID
  130005268091
- ISSN
  0032-6313, 1884-4545
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K20181
[Journal Article] The tumor-suppressive microRNA-23b/27b cluster regulates the MET oncogene in oral squamous cell carcinoma.2016
- Author(s)
  Fukumoto I, Koshizuka K, Hanazawa T, Kikkawa N, Matsushita R, Kurozumi A, Kato M, Okato A, Okamoto Y, Seki N.
- Journal Title
  
  Int J Oncol.
  
  Volume: 49（3） Issue: 3 Pages: 1119-29
- DOI
  10.3892/ijo.2016.3602
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-26462596, KAKENHI-PROJECT-15K10800, KAKENHI-PROJECT-15K10801, KAKENHI-PROJECT-16K11224
[Journal Article] Basal cell adenoma of the parotid gland; MR features and differentiation from pleomorphic adenoma.2016
- Author(s)
  Mukai H, Motoori K, Horikoshi T, Takishima H, Nagai Y, Okamoto Y, Uno T.
- Journal Title
  
  Dentomaxillofac Radiol.
  
  Volume: 45（4） Pages: 20150322-20150322
- Data Source
  KAKENHI-PROJECT-24249081
[Journal Article] Initial experience of radiotherapy plus cetuximab for Japanese head and neck cancer patients.2015
- Author(s)
  Kurokawa M, Watanabe Nemoto M, Harada R, Kobayashi H, Horikoshi T, Kanazawa A, Togasaki G, Abe Y, Chazono H, Hanazawa T, Okamoto Y, Uno T.
- Journal Title
  
  J Radiat Res.
  
  Volume: 56(5) Issue: 5 Pages: 849-55
- DOI
  10.1093/jrr/rrv038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249081
[Journal Article] The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway.2015
- Author(s)
  Endo, Y., Hirahara, K., Iinuma, T., Shinoda, K., Tumes, D. J., Asou, H. K., Matsugae, N., Obata-Ninomiya, K., Yamamoto, H., Motohashi, S., Oboki, K, Nakae, S., Saito, H., Okamoto, Y., and Nakayama, T.
- Journal Title
  
  Immunity
  
  Volume: 42(2) Issue: 2 Pages: 294-308
- DOI
  10.1016/j.immuni.2015.01.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-24591475, KAKENHI-PROJECT-25893032, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-26870172
[Journal Article] Feasibility of carbon ion radiotherapy for locally advanced sinonasal adenocarcinoma.2014
- Author(s)
  Koto M, Hasegawa A, Takagi R, Sasahara G, Ikawa H, Mizoe JE, Jingu K, Tsujii H, Kamada T, Okamoto Y,Organizing Committee for the Working Group for Head-and-Neck Cancer.
- Journal Title
  
  Radiother Oncol.
  
  Volume: 113(1) Issue: 1 Pages: 60-5
- DOI
  10.1016/j.radonc.2014.09.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249081
[Journal Article] microRNA-504 inhibits cancer cell proliferation via targeting CDK6 in hypopharyngeal squamous cell carcinoma.2014
- Author(s)
  Kikkawa N, Kinoshita T, Nohata N, Hanazawa T, Yamamoto N, Fukumoto I, Chiyomaru T, Enokida H, Nakagawa M, Okamoto Y, Seki N.
- Journal Title
  
  Int J Oncol.
  
  Volume: 44(6) Issue: 6 Pages: 2085-92
- DOI
  10.3892/ijo.2014.2349
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-24592590, KAKENHI-PROJECT-25861528
[Journal Article] Effects of the dose-volume relationship on and risk factors for maxillary osteoradionecrosis after carbon ion radiotherapy.2014
- Author(s)
  Sasahara G, Koto M, Ikawa H, Hasegawa A, Takagi R, Okamoto Y, Kamada T.
- Journal Title
  
  Radiat Oncol.
  
  Volume: 9(1) Issue: 1 Pages: 92-92
- DOI
  10.1186/1748-717x-9-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249081
[Journal Article] NKT cells as an ideal target for anti-tumor immunotherapy2013
- Author(s)
  Fujii S, Shimizu K, Okamoto Y, Kunii N, Nakayama T, Motohashi S, Taniguchi M
- Journal Title
  
  Front. Immunol
  
  Volume: 4 Pages: 409-409
- DOI
  10.3389/fimmu.2013.00409
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380186, KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-24592083, KAKENHI-PROJECT-23229005
[Journal Article] Tumour-suppressive microRNA-29s inhibit cancer cell migration and invasion by targeting laminin-integrin signalling in head and neck squamous cell carcinoma.2013
- Author(s)
  Kinoshita T, Nohata N, Hanazawa T, Kikkawa N, Yamamoto N, Yoshino H, Itesako T, Enokida H, Nakagawa M, Okamoto Y, Seki N.
- Journal Title
  
  Br J Cancer
  
  Volume: 109 Issue: 10 Pages: 2636-2645
- DOI
  10.1038/bjc.2013.607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592505, KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-24592590, KAKENHI-PROJECT-25670694, KAKENHI-PROJECT-25861528
[Journal Article] Tumour-suppressive microRNA-874 contributes to cell proliferation through targeting of histone deacetylase 1 in head and neck squamous cell carcinoma.2013
- Author(s)
  Nohata N, Hanazawa T, Kinoshita T, Inamine A, Kikkawa N, Itesako T, Yoshino H, Enokida H, Nakagawa M, Okamoto Y, Seki N.
- Journal Title
  
  Br J Cancer
  
  Volume: 108 Issue: 8 Pages: 1648-1658
- DOI
  10.1038/bjc.2013.122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592505, KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-24592575, KAKENHI-PROJECT-25861528
[Journal Article] Tumor suppressive microRNA-133a regulates novel targets: Moesin contributes to cancer cell proliferation and invasion in head and neck squamous cell carcinoma.2012
- Author(s)
  Kinoshita T, Nohata N, Fuse M, Hanazawa T, Kikkawa N, Fujimura L, Takano H, Yamada Y, Yoshino H, Enokida H, Nakagawa M, Okamoto Y, Seki N.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 418 Pages: 1821-1830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249081
[Journal Article] Actin-related protein 2/3 complex subunit 5 (ARPC5) contributes to cell migration and invasion and is directly regulated by tumor-suppressive microRNA-133a in head and neck squamous cell carcinoma.2012
- Author(s)
  Kinoshita T, Nohata N, Watanabe-Takano H, Yoshino H, Hidaka H, Fujimura L, Fuse M, Yamasaki T, Enokida H, Nakagawa M, Hanazawa T, Okamoto Y, Seki N.
- Journal Title
  
  Int J Oncol.
  
  Volume: 40 Pages: 1770-1778
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249081
[Journal Article] Plectin promotes migration and invasion of cancer cells and is a novel probnostic marker for head and neck squamous cell carcinoma.2012
- Author(s)
  Katada K,Tomonaga T, Satoh M, Matsushita K, Tonoike Y, Kodera Y, Hanazawa T, Nomura F, Okamoto Y.
- Journal Title
  
  Journal of Proteomics.
  
  Volume: 75 Pages: 1803-1815
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249081
[Journal Article] Afibrin glue is a candidate scafford for long-term therapeutic protein expression in spontaneously differentiated adipocytes in vitro.2012
- Author(s)
  Aoyagi Y,Kuroda M,Asada S,Tanio M,Aso M,Okamoto Y,Saito Y,Bujo H.
- Journal Title
  
  Experimental Cell Reseach
  
  Volume: 318 Pages: 1090-1112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249081
[Journal Article] Migration and immunological reaction after the administration of α-GalCer-pulsed- antigen-presenting cells into the submucosa of patients with head and neck cancer2011
- Author(s)
  Kurosaki, M., Horiguchi, S., Yamasaki, K., Uchida, Y., Motohashi, S., Nakayama, T., Sugimoto, A., Okamoto, Y
- Journal Title
  
  Cancer Immunology and Immunotherapy
  
  Volume: 60 Pages: 207-215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390458
[Journal Article] Anti-tumor immune responses induced by iNKT cell-based immunotherapy for lung cancer and head and neck cancer2011
- Author(s)
  Motohashi S, Okamoto Y, Yoshino I, Nakayama T
- Journal Title
  
  Clinical Immunology
  
  Volume: 140 Pages: 167-176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390458
[Journal Article] Nasal submucosal administration of antigen-presenting cells induces effective immunological responses in cancer immunotherapy2011
- Author(s)
  Okamoto Y, Fujikawa A, Kurosaki M, Yamasaki K, Sakurai D, Horiguchi S, Nakayama T
- Journal Title
  
  Advances in Oto-Rhino-Laryngology
  
  Volume: 72 Pages: 149-152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390458
[Journal Article] Nasal submucosal administration of antigen-presenting cells induces effective immunological responses in cancer immunotherapy2011
- Author(s)
  Okamoto Y
- Journal Title
  
  Oto-Rhino-Laryngology
  
  Volume: 72 Pages: 149-152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390458
[Journal Article] Induction of NKT cell-specific immune responses in cancer tissues after NKT cell-targeted adoptive immunotherapy2011
- Author(s)
  Yamasaki, K., Horiguchi, S., Kurosaki, M., Kunii, N., Nagato, K., Hanaoka, H., Shimizu, N., Ueno, N., Yamamoto, S., Taniguchi, M., Motohashi, S., Nakayama, T., Okamoto, Y
- Journal Title
  
  Clinical Immunology
  
  Volume: 138 Pages: 255-265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390458
[Journal Article] The effect of radiotherapy on NKT cells in patients with advanced head and neck cancer2010
- Author(s)
  Kobayashi, K., Tanaka, Y., Horiguchi, S., Yamamoto, S., Nakayama, T., Sugimoto, A., Okamoto, Y
- Journal Title
  
  Cancer Immunology and Immunotherapy
  
  Volume: 59 Pages: 1503-1509
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390458
[Journal Article] 気管食道科からみたone airway,one disease2009
- Author(s)
  岡本美孝
- Journal Title
  
  気管食道科学会会報 60
  
  Pages: 153-154
- Data Source
  KAKENHI-PROJECT-19591956
[Journal Article] 上気道の粘膜:基礎から臨床へ-鼻アレルギー・頭頸部癌の免疫治療への展開2009
- Author(s)
  岡本美孝
- Journal Title
  
  耳鼻咽喉科・頭頸部外科 81
  
  Pages: 887-896
- Data Source
  KAKENHI-PROJECT-21390458
[Journal Article] Combination Therapy of In vitro Expanded Natural Killer T Cells and α-Galactosylceramide-pulsed Antigen Presenting Cells in Patients with Recurrent Head and Neck Carcinoma2009
- Author(s)
  Kumii, N., Horiguchi, S., Motohashi, S., Yamamoto, H., Ueno, N., Yamamoto, S., Sakurai, D., Taniguchi, M., Nakayama, T., Okamoto, Y
- Journal Title
  
  Cancer Science
  
  Volume: 100 Pages: 1092-1098
- NAID
  10025146740
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390458
[Journal Article] Mucosal malignant melanoma of the head and neck treated by carbon ion radiotherapy2009
- Author(s)
  Yanagi T, Mizoe JE, Hasegawa A, Takagi R, Bessho H, Onda T, Kamada T, Okamoto Y, Tsujii H
- Journal Title
  
  International Journal of Radiation Oncology
  
  Volume: 74 Pages: 15-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390458
[Journal Article] Seasonal changes in antigen-specific T-helper clone sizes in patients with Japanese cedar pollinosis : a 2-year study2008
- Author(s)
  Horiguchi S, Tanaka Y, Uchida T, Chazono H, Okawa T, Sakurai D, Okamoto Y.
- Journal Title
  
  Clin Exp Allergy 38(3)
  
  Pages: 405-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591957
[Journal Article] Lowered effectiveness of immunotherapy for cypress pollinosis by using Japanese cedar pollen extract2008
- Author(s)
  Horiguchi S, Okamoto Y, Yonekura S, Okawa T, Kunii N, Yamamoto H, Sakurai D, Hanazawa T.
- Journal Title
  
  Arerugi 57(5)
  
  Pages: 558-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591957
[Journal Article] A randomized controlled trial of sublingual immunotherapy for Japanese cedar pollinosis2008
- Author(s)
  Horiguchi S, Okamoto Y, Yonekura S, Okawa T, Yamamoto H, Kunii N, Sakurai D, Fujimura T, Nakazawa K, Yasueda H.
- Journal Title
  
  Int Arch Allergy Immunol. 146(1)
  
  Pages: 76-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591957
[Journal Article] Detection of natural killer T cells in the sinus mucosa from asthmatics with chronic sinusitis2007
- Author(s)
  Yamamoto H, Okamoto Y, Horiguchi S, Kunii N, Yonekura S, Nakayama T.
- Journal Title
  
  Allergy 62
  
  Pages: 1451-1455
- Data Source
  KAKENHI-PROJECT-19591956
[Journal Article] 上気道の急性感染症と慢性感染症との違い2005
- Author(s)
  岡本美孝
- Journal Title
  
  JOHNS 21
  
  Pages: 148-150
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591776
[Journal Article] Influence of viral infection on the development of nasal hypersensitivity2005
- Author(s)
  Y.Okamoto, Z.Matsuzaki, T.Matsuoka, S.Endo, H.Yamamoto, H.Chazono, S.Horiguchi, T.Hanazawa
- Journal Title
  
  Clinical and Experimental Allergy 35
  
  Pages: 679-684
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591776
[Journal Article] The different characteristics observed between acute and chronic infectious diseases in the upper respiratory infection.2005
- Author(s)
  Y.Okamoto.
- Journal Title
  
  JOHNS 21
  
  Pages: 148-150
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591776
[Journal Article] Influence of viral infection on the development of nasal hypersensitivity.2005
- Author(s)
  Yoshitaka Okamoto
- Journal Title
  
  Clinical and Experimental Allergy 37
  
  Pages: 674-684
- Data Source
  KAKENHI-PROJECT-17591776
[Journal Article] Present situation of cedar pollinosis in Japan and its immune responses
- Author(s)
  Okamoto Y, Horiguchi S, YamamotoH, YonekuraS, Hanazawa T.
- Journal Title
  
  Allergology International (in press)
- NAID
  10025109444
- Data Source
  KAKENHI-PROJECT-19591956
[Journal Article] Present situation of cedar pollinosis in Japan and its immune responses
- Author(s)
  Okamoto Y.
- Journal Title
  
  Allergology International (In press)
- NAID
  10025109444
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591956
[Journal Article] 気管食道科とone airway,onedisease
- Author(s)
  岡本美孝
- Journal Title
  
  気管食道科学会会報 (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591956
[Presentation] スギ花粉症の舌下免疫療法の奏効性は血清中IgEの架橋能と相関する2019
- Author(s)
  中村亮介, 秋山晴代, 櫻井大樹, 松澤由美子, 斎藤嘉朗, 岡本美孝
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16H05483
[Presentation] セツキシマブによる牛肉アレルギー患者血清中IgE架橋活性の解析2018
- Author(s)
  中村亮介, 岡本(内田)好海, 千貫祐子, 斎藤嘉朗, 森田栄伸
- Organizer
  第67回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-16H05483
[Presentation] Crosslinking ability of the serum IgE correlates to the effectiveness of allergen immunotherapy for Japanese cedar pollen2018
- Author(s)
  Nakamura R, Akiyama H, Sakurai D, Matsuzawa Y, Saito Y, Okamoto Y
- Organizer
  WISC 2018
- Data Source
  KAKENHI-PROJECT-16H05483
[Presentation] 舌下免疫療法実施時における血清中中和抗体活性のin vitro評価法の開発2018
- Author(s)
  秋山晴代, 中村亮介, 櫻井大樹, 平野吉彬, 根来孝治, 岡本美孝
- Organizer
  第67回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-16H05483
[Presentation] Different responses of basophils to allergen between sensitized-asymptomatic subjects and patients with allergic rhinitis.2017
- Author(s)
  Okamoto Y, Yonekura S, Arai T, Sakurai D.
- Organizer
  AAAAI2017
- Place of Presentation
  アトランタ
- Year and Date
  2017-03-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05483
[Presentation] 頭頸部扁平上皮癌患者における制御性T細胞の機能的分画と臨床的意義2016
- Author(s)
  伊原史英, 堀中敦史, 蒔田勇治, 國井直樹, 櫻井大樹, 岡本美孝
- Organizer
  日本頭頸部癌学会
- Place of Presentation
  ソニックシティ（埼玉県・さいたま市）
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-15K20181
[Presentation] The functional subsets of regulatory T cells correlate with clinical outcome .2016
- Author(s)
  Ihara F, Sakurai D, Motohashi S, Kunii N, Okamoto Y.
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] The functional subsets of regulatory T cells correlate with clinical outcome and invariant NKT cells suppression in head and neck cancer patients.2016
- Author(s)
  Ihara F, Sakurai D, Kunii N, Motohashi S, Okamoto Y.
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] A randomized double-blind phase II trial evaluating adjuvant therapy for advanced oro- and hypo-pharyngeal cancer using the injection of alpha-GalCer-loaded DCs into the nasal submucosa.2016
- Author(s)
  Kunii N, Makita Y, Ihara F, Sakurai D, Motohashi S, Nakayama T, Okamoto Y.
- Organizer
  第20回日本がん免疫学会総会
- Place of Presentation
  大阪国際交流センター（大阪府大阪市）
- Year and Date
  2016-07-27
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] 制御性T細胞の機能的分類と臨床経過との関連2016
- Author(s)
  伊原史英, 櫻井大樹, 本橋新一郎, 國井直樹, 岡本美孝
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K20181
[Presentation] 中咽頭癌におけるエピゲノム変化とHPV感染の検討2016
- Author(s)
  中川拓也, 松坂恵介, 高根希世子, 福世真樹, 太田聡, 中谷行雄, 國井直樹, 櫻井大樹, 花澤豊行, 岡本美孝, 金田篤志
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K20181
[Presentation] 中下咽頭癌CR例に対するiNKT細胞アジュバント療法の有効性に関するランダム化試験2016
- Author(s)
  國井直樹, 山崎一樹, 茶薗英明, 花澤豊行, 岡本美孝
- Organizer
  日本口腔咽頭科学会
- Place of Presentation
  松江テルサ（島根県・松江市）
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-15K20181
[Presentation] Current concepts on immune mechanisms of sublingual immunotherapy2016
- Author(s)
  Okamoto Y.
- Organizer
  18th Asian Research Symposium of Rhinology
- Place of Presentation
  クアラルンプール
- Year and Date
  2016-05-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05483
[Presentation] Efficacy and safety of S-524101 in mono-sensitized and poly-sensitized patients with allergic rhinitis in Japan Phase 2/3 study2016
- Author(s)
  Okamoto Y, Fujieda S, Masuyaka K, Okano M, Kakudo M.
- Organizer
  EAACI2016
- Place of Presentation
  ウィーン
- Year and Date
  2016-06-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05483
[Presentation] A Randomized Double-blind Phase II Trial Evaluating Adjuvant Therapy for Advanced Oro- and Hypo-pharyngeal Cancer using the Injection of aGalCer-loaded DCs into the Nasal Submucosa.2016
- Author(s)
  Naoki Kunii, Yuji Makita, Fumie Ihara, Daiju Sakurai, Shinichiro Motohashi, Toshinori Nakayama, Yoshitaka Okamoto.
- Organizer
  第20回日本がん免疫学会総会
- Place of Presentation
  大阪国際交流センター（大阪府大阪市）
- Year and Date
  2016-07-27
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] Analysis of regulatory T cells in peripheral blood of the patients with Head and Neck cancer and their inhibitory role on NKT cells2015
- Author(s)
  Ihara, F., Sakurai, D., Motohashi, S., and Okamoto, Y.
- Organizer
  International Conference of Cancer Immunotherapy and Macrophages 2015
- Place of Presentation
  Ito Hall, Ito International Research Center, The University of Tokyo
- Year and Date
  2015-07-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] 標準治療後の進行期中・下咽頭癌症例に対するαGalCerパルス樹状細胞療法の有効性に関するランダム二重盲検試験2015
- Author(s)
  國井直樹、蒔田勇治、伊原史英、内田亮介、佐々原剛、藤川陽、櫻井大樹、岡本美孝
- Organizer
  日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  東武レバントホテル（東京都墨田区）
- Year and Date
  2015-02-27
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] 標準治療後の進行期中・下咽頭癌症例に対するαGalCerパルス樹状細胞療法の有効性に関するランダム化二重盲検試験2015
- Author(s)
  國井直樹、蒔田勇治、伊原史英、内田亮介、佐々原剛、藤川陽、櫻井大樹、岡本美孝
- Organizer
  日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  東武レバントホテル（東京都墨田区）
- Year and Date
  2015-02-27
- Data Source
  KAKENHI-PROJECT-25861526
[Presentation] Antigen Specific Immunotherapy Based on Chimeric Antigen Receptor Expressing T Cells Targeted to Salivary Gland Tumor2015
- Author(s)
  Kunii, N., Makita, Y., Ihara, F., Uchida, R., Fujikawa, A., Motohashi, S., Nakayama, T., and Okamoto, Y.
- Organizer
  International Conference of Cancer Immunotherapy and Macrophages 2015
- Place of Presentation
  Ito Hall, Ito International Research Center, The University of Tokyo
- Year and Date
  2015-07-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] Antigen Specific Immunotherapy Based on Chimeric Antigen Receptor Expressing T Cells Targeted to Salivary Gland Tumor2014
- Author(s)
  Kunii, N., Makita, Y., Ihara, F., Uchida, R., Fujikawa, A., Sakurai, D., Motohashi, S., Nakayama, T. and Okamoto, Y.
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  国立京都国際会館（京都府京都市左京区）
- Year and Date
  2014-12-11
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] 唾液腺癌に対する抗原特異的T細胞の細胞傷害活性は活性化NKT細胞によって相乗的に増強する2014
- Author(s)
  蒔田勇治、國井直樹、岡本美孝
- Organizer
  日本唾液腺学会学術集会
- Place of Presentation
  文京学院大学（東京都文京区）
- Year and Date
  2014-12-06
- Data Source
  KAKENHI-PROJECT-25861526
[Presentation] The Antigen Specific Immunotherapy Based on the Chimeric Antigen Receptor Expressing T cells Targeted to Salivary Gland Tumor2014
- Author(s)
  Naoki KUNII, Yuji MAKITA, Fumie IHARA, Ryosuke UCHIDA, Akira FUJIKAWA, Daiju Sakurai, Shinichiro MOTOHASHI, Toshinori NAKAYAMA and Yoshitaka OKAMOTO
- Organizer
  日本免疫学会
- Place of Presentation
  国立京都国際会館（京都市左京区）
- Year and Date
  2014-12-11
- Data Source
  KAKENHI-PROJECT-25861526
[Presentation] 唾液腺癌に対する抗原特異的T細胞の細胞傷害活性は活性化NKT細胞によって相乗的に増強する2014
- Author(s)
  蒔田勇治、國井直樹、岡本美孝
- Organizer
  日本唾液腺学会学術集会
- Place of Presentation
  文教学院大学（東京都文京区）
- Year and Date
  2014-12-06
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] 骨髄系免疫抑制細胞の頭頸部腫瘍における検討2014
- Author(s)
  堀中敦史、本橋新一郎、岡本美孝
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] NKT細胞免疫系をターゲットにしたがんの免疫細胞治療ー10年間の臨床研究の成果と今後の展望ー2013
- Author(s)
  中山俊憲、本橋新一郎、國井直樹、岡本美孝
- Organizer
  第17回日本がん免疫学会総会
- Place of Presentation
  ANAクラウンプラザホテル宇部
- Invited
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] Phase I/II clinical study of α-galactosylceramide-pulsed antigen presenting cells as adjuvant immunotherapy for patients with head and neck mucosal malignant melanoma after carbon ion radiotherapy.2013
- Author(s)
  Fujikawa, A., Kunii, N., Horinaka, A., Makita, Y., Uchida, R., Ihara, F., Motohashi, S., Okamoto, Y., and Nakayama, T.
- Organizer
  第42回日本免疫学会総会学術集会
- Place of Presentation
  幕張メッセ
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] NKT cell-targeting therapy for lung cancer and head and neck cancer.2013
- Author(s)
  Motohashi, S., Kunii, N., Taniguchi, M., Yoshino, I., Okamoto, Y., and Nakayama, T.
- Organizer
  7th International symposium on CD1 and NKT cells
- Place of Presentation
  Tours France
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] 炭素イオン線治療後の頭頸部粘膜悪性黒色腫患者に対するaガラクトシルセラミドパルス抗原提示細胞を用いたアジュバント免疫治療に関する第I/II相臨床研究2013
- Author(s)
  藤川陽,國井直樹,櫻井大樹,長谷川安都佐,鎌田正,溝江純悦,岡本美孝,本橋新一郎,中山俊憲
- Organizer
  第17回日本がん免疫学会総会
- Place of Presentation
  ANAクラウンプラザホテル宇部
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] 新しい頭頸部癌治療の展望:自然免疫系(NKT細胞)を利用した細胞免疫療法2011
- Author(s)
  山崎一樹, 茶薗英明, 堀口茂俊, 花澤豊行, 岡本美孝
- Organizer
  第35回日本頭頸部癌学会
- Place of Presentation
  名古屋
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-21390458
[Presentation] NKT cell-based immunotherapy for cancer:Nasal sumucosal administration of antigen-presenting cells may induce effective anti-tumor immune responses2010
- Author(s)
  岡本美孝
- Organizer
  第4回千葉大学Global COEシンポジウム
- Place of Presentation
  千葉
- Year and Date
  2010-08-20
- Data Source
  KAKENHI-PROJECT-21390458
[Presentation] Phase II study of Activated NKT Cells and α-GalCer-pulsed DCs in Patients with recurrent and operable Head and Neck Carcinoma2010
- Author(s)
  Yamasaki K, Katada K, Kikkawa N, Yonekura S, Okamoto Y
- Organizer
  13th KJ Joint Meeting of Otorhinolaryngology Head & Neck Surgery
- Place of Presentation
  Seoul/ Kore
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-21390458
[Presentation] Nasal submucosal administration of antigen-presenting cells indued effective immunological response in cancer immunotherap2010
- Author(s)
  岡本美孝, 藤川陽, 稲嶺絢子
- Organizer
  第7回国際上気道粘膜・扁桃学会
- Place of Presentation
  旭川
- Data Source
  KAKENHI-PROJECT-21390458
[Presentation] Nasal submucosal administration of antigen-presenting cells indued effective immunological response in cancer immunotherapy2010
- Author(s)
  岡本美孝
- Organizer
  第7回国際上気道粘膜・扁桃学会
- Place of Presentation
  旭川
- Data Source
  KAKENHI-PROJECT-21390458
[Presentation] 頭頸部扁平上皮癌に対する活性化NKT細胞とα-GalCerパルス抗原提示細胞投与による第二相臨床試験2010
- Author(s)
  山崎一樹, 堀口茂俊, 藤川陽, 佐々原剛, 米倉修二, 花澤豊行, 岡本美孝
- Organizer
  第111回日本耳鼻咽喉科学会総会・学術講演会
- Place of Presentation
  仙台
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-21390458
[Presentation] 気管食道科とone airway, one disease2008
- Author(s)
  岡本美孝
- Organizer
  第60回日本気管食道科学会総会
- Place of Presentation
  熊本市
- Year and Date
  2008-11-04
- Data Source
  KAKENHI-PROJECT-19591956
[Presentation] 気管食道科とone airway,onedisease2008
- Author(s)
  岡本美孝
- Organizer
  気管食道科学会総会
- Place of Presentation
  熊本市
- Year and Date
  2008-11-04
- Data Source
  KAKENHI-PROJECT-19591956
[Presentation] Allergic rhinitis in Japan and it's immune responses2007
- Author(s)
  Okamoto Y.
- Organizer
  第57回日本アレルギー学会秋季学術大会プレコングレスカンファランス
- Place of Presentation
  横浜市
- Year and Date
  2007-10-31
- Data Source
  KAKENHI-PROJECT-19591956
[Presentation] 慢性副鼻腔炎の病態形成に及ぼす喘息合併の意義2007
- Author(s)
  山本陛三朗. 堀口茂俊. 岡本美孝
- Organizer
  第57 回日本アレルギー学会秋季学術大会
- Place of Presentation
  横浜市
- Year and Date
  2007-11-01
- Data Source
  KAKENHI-PROJECT-19591956
[Presentation] ユビキチン化抵抗性LATによるT細胞のエフェクター機能の強化
- Author(s)
  國井直樹、櫻井大樹、岡本美孝
- Organizer
  第31回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  倉敷市芸文館（岡山県）
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] Enhanced function of redirected human T cells expressing LAT thatis
- Author(s)
  Naoki Kunii, Shinichiro Motohashi, Kaoru Nagato, Yoshitaka Okamoto, Toshinori Nakayama
- Organizer
  第16回日本癌免疫学会
- Place of Presentation
  北海道大学学術交流会館
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] Enhanced function of primary human T cells electroporated with RNA for LAT that is resistant to ubiquitylation
- Author(s)
  KUNII Naoki, MOTOHASHI Shinichiro, OKAMOTO Yoshitaka, NAKAYAMA Toshinori
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸国際会議場（兵庫県）
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] ユビキチン化抵抗性LATによるT細胞の機能増強
- Author(s)
  國井直樹、本橋新一郎、岡本美孝、中山俊憲
- Organizer
  第71回日本癌学会
- Place of Presentation
  ロイトン札幌（北海道
- Data Source
  KAKENHI-PROJECT-24249081

1. HORIGUCHI Shigetoshi (30293468)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
2. MATSUZAKI Zensei (90283217)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. J-J Delaunay (80376516)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. HANAZAWA Toyoyuki (90272327)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
5. KUNII Naoki (00456047)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
6. ITO Eiko (90006734)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. KAMIJO Atsushi (90252022)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. SUZUKI Homare (10344988)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. TERADA Nobuhisa (70197797)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. SAKURAI Daijyu (10375636)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
11. Tabata Hitoshi (00263319)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. MAKITA Yuji (90706722)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
13. SARASHINA Norio (70235448)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. OKAWA Toru (40344981)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. YAMASAKI Kazuki (00422238)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
16. NAGATO Keisuke (50546231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. YANAGIMOTO Shintaro (30463889)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. MATSUOKA Tomokazu (30313810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. MIZUKOSHI Akihito (00283218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. TERAKAWA Susumu (50014246)

# of Collaborated Projects: 1 results

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21. MOGI Goro (20035190)

# of Collaborated Projects: 1 results

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22. KIYONO Hiroshi (10271032)

# of Collaborated Projects: 1 results

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23. SUZUKI Masashi (60211314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. KURONO Yuichi (80153427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. KAWAUCHI Hideyuki (50161279)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. OGINO Jun (00177156)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. SHIMOJO Naoki (40221303)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. Nakamura Ryosuke (50333357)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
29. Suzuki Yuji (80222066)

# of Collaborated Projects: 1 results

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30. SUZUKI TAKESHI (20422230)

# of Collaborated Projects: 1 results

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31. YONEKURA Syuji (20400939)

# of Collaborated Projects: 1 results

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32. OKUMA Yusuke (50745825)

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33. MORIMOTO Yuki (40802575)

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34. 白澤浩 (00216194)

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35. 関直彦 (50345013)

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36. 本橋新一郎 (60345022)

# of Collaborated Projects: 1 results

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37. 福本一郎 (70748764)

# of Collaborated Projects: 1 results

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38. 藤川茂紀 (60333332)

# of Collaborated Projects: 1 results

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39. 前田悦男 (60644599)

# of Collaborated Projects: 1 results

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40. 菊島一仁 (70242659)

# of Collaborated Projects: 1 results

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41. 長田久夫 (30233505)

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42. 秋山晴代 (50420229)

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43. 岡本好海 (40716792)

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44. 三田吉郎 (40323472)

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45. CARL H. June

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46. June Carl H.

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47. FUJII Shinーichiro

# of Collaborated Projects: 0 results

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48. 吉川直子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. 平原潔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
50. 清水佳奈子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okamoto Yoshitaka 岡本 美孝

OKAMOTO Yoshitaka 岡本 美孝

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Development of adjuvant therapy for head and neck cancer by activation of NKT cells via nasal mucosaPrincipal Investigator

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Adjuvant cellular immnunotherapy for head and neck cancerPrincipal Investigator

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Role of NKT cells in the eosinophilic diseases in upper respiratory tract and approachfor a new treatmentPrincipal Investigator

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Role of infectious diseases in allergic rhinitisPrincipal Investigator

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Okamoto Yoshitaka 岡本美孝

OKAMOTO Yoshitaka 岡本美孝