HIGUCHI Shun 樋口駿

… Alternative Names

樋口駿ヒグチシュン

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Researcher Number	40218699
External Links
Affiliation (based on the past Project Information) *help	2007 – 2009: Kyushu University, 大学院・薬学研究院, 教授 2006: Kyushu University, Faculty of Pharmaceutical Sciences, Professor, 大学院薬学研究院, 教授 2000 – 2005: Graduate School of Pharmaceutical Sciences, KYUSHU UNIVERSITY Professor, 大学院・薬学研究院, 教授 2004: 九州大学, 薬学研究院, 教授 2001 – 2002: 九州大学, 大学院・薬学研究府, 教授 … More 1999: 九州大学, 薬学研究科, 教授 1997 – 1999: 九州大学, 大学院・薬学研究科, 教授 1998: 九州大学, 薬学部, 教授 1994: 九州大学, 大学院薬学研究科, 教授 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / 応用薬理学・医療系薬学 / Applied pharmacology Except Principal Investigator 応用薬理学・医療系薬学 / Biological Sciences / Medical pharmacy / Digestive surgery
Keywords	Principal Investigator adriamycin / cisplatin / antitumor effect / adverse effect / docetaxel / chemotherapy / dosing schedule / MRP2 / MDR1 / decetaxel … More / cancer chemotherapy / biological rhythm marker / chronotherapy / irinotecan hydrochloride / 時計遺伝子 / ガン化学療法 / 生体リズムマーカー / 時間治療 / 塩酸イリノテカン / エピジェネティックス / SNPs / 発現制御 / CYP3A4 / インプリンティング / miRNA / コピーナンバー多型 / bcrp / mrp2 / mdr1 / chronopharmacology / 遺伝子多型 / 遺伝的多型 / cMOAT / MRP1 / ABCトランスポーター … More Except Principal Investigator 生体リズム / HPLC / 時計遺伝子 / 時間薬理学 / 細胞動態 / circadian rhythm / melatonin / サーカディアンリズム / メラトニン / BCRP / MDR1 / 臨床試験 / Chronopharmacology / Biological Rhythm / 視交叉上核 / マウス / 時間薬理 / clinical marker / sleeping disorder / Fluorescence detection / sleeping / D-alanine / D-アラニン抗体 / 分析科学 / 睡眠時無呼吸症候群 / 4-キノロン / 概日リズム / 臨床マーカー / 睡眠障害 / 蛍光検出 / 睡眠 / D-アラニン / Cancer / Biological clock / Biological rhythm / 発癌 / 体内時計 / microanalysis / rhyrhm disturbance / chronotherapy / blood sample / tailor-made medical treatment / テイラーメイド医療 / 微量分析 / リズム障害 / 時間治療 / 血液試料 / テーラーメイド医療 / Chronopharmacokinetics / Suprachiasmatic Nuclei / Clock genes / 時間薬物動態学 / Clinical Study / Basic research / P-glycoprotein / ABC transporters / オーダーメイド医療 / ジゴキシン / モルヒネ / 遺伝子多型 / 薬物脳移行 / MRPs遺伝子 / MDR1遺伝子 / 中枢毒性 / SNPs / 部分肝移植 / タクロリムス / diplotype / hapolotype / 胎盤 / 4MU / 基礎研究 / p-糖タンパク / ABCトランスポーター / prediction of adverse reactions / Prescription / catalepsy / dopamine receptor / Parkinsonism / 副作用予測 / 処方設計 / カタレプシー / ドパミン受容体 / パーキンソニズム / pharmacogenetics / clinical trials / drug information / Prescription-inspection supporting system / avoidance of side effects / drug interaction / データベース / グレープフルーツジュース / P-糖タンパク質 / クリアランス理論 / 処方オーダリング / 薬理遺伝学 / 医薬品情報 / 処方設計支援システム / 副作用回避 / 薬物相互作用 / mouse / Suprachiasmatic nuclei / Interferon / Pharmacokinetics / 視交又上核 / インターフェロン / 薬物動態 / 抗癌剤 / セルロプラスミン / 薬物間相互作用 / アセトアミノフェン / シサプリド / 膵頭十二指腸切除 / 消化管運動機能 Less

薬物間相互作用および腫瘍の生体リズムを基盤とした個別化治療予測システムの開発
- Principal Investigator
  
  藤秀人
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Alternative mechanisms of gene regulation for pharmacokinetics related genesPrincipal Investigator
- Principal Investigator
  
  HIGUCHI Shun
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyushu University
抗腫瘍効果に及ぼす腫瘍組織中トランスポーター発現の日周リズムPrincipal Investigator
- Principal Investigator
  
  樋口駿
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyushu University
Assessment of sleeping quality using integrated new chemical index derived from melatonin and D-alanine values
- Principal Investigator
  
  ZAITSU Kiyoshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  KYUSHU UNIVERSITY
時計遺伝子を基盤にした細胞動態の日周リズムの成因解明と診断法の開発
- Principal Investigator
  
  大戸茂弘
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Molecular clock mechanism of cancer
- Principal Investigator
  
  OHDO Shigehiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  KYUSHU UNIVERSITY
Construction of optimal combined chemotherapy of anti-tumor drugs based on chronotherapyPrincipal Investigator
- Principal Investigator
  
  HIGUCHI Shun
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kyushu University
時計遺伝子を基盤にした細胞動態の日周リズムの成因解明と診断法の開発
- Principal Investigator
  
  大戸茂弘
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
時計遺伝子を基盤にした細胞動態の日周リズムの成因解明と診断法の開発
- Principal Investigator
  
  OHDO Shigehiro
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Study for cancer chronotherapy based on clock genePrincipal Investigator
- Principal Investigator
  
  HIGUCHI Shun
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kyushu University
New approach to tailor-made medical treatment based on the ultra-sensitive assay of melatonin
- Principal Investigator
  
  ZAITSU Kiyoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  KYUSHU UNIVERSITY
In vivo functional characterization of the ABC transporters based on the genetic polymorphisms
- Principal Investigator
  
  IEIRI Ichiro
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tottori University
Development of Chronotherapy Based on Clock Genes
- Principal Investigator
  
  OHDO Shigehiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kyushu University
ABCトランスポーター遺伝子の多型解析と臨床意義の解明Principal Investigator
- Principal Investigator
  
  樋口駿
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kyushu University
Development of the strategy for the quantitative prediction and avoidance of drug-induced Parkinsonism based on pharmacokinetics and pharmacodynamics
- Principal Investigator
  
  SAWADA Yasufumi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  KYUSHU UNIVERSITY
Quantitative evaluation of drug interactions and development of a prescription-supporting system for the avoidance of adverse effects
- Principal Investigator
  
  IGA Tatsuji
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  The University of Tokyo
Development of the mouse model with 24-hour rhythm disturbances
- Principal Investigator
  
  OHDO Shigehiro
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  KYUSHU UNIVERSITY
幽門温存膵頭十二指腸切除と十二指腸温存膵頭切除術後の胃排出能障害の比較と治療
- Principal Investigator
  
  田中雅夫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University

All 2009 2005

All Journal Article Presentation

[Journal Article] Influence of dosing schedules on toxicity and antitumour effects of combined cisplatin and docetaxel treatment in mice.2009
- Author(s)
  Kodama A., To H., Kinoshita T., Ieiri I., Higuchi S.
- Journal Title
  
  J.Pharm.Pharmacol. 61
  
  Pages: 615-621
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20014019
[Journal Article] Role of glucocorticoid receptor in the regulation of cellular sensitivity to irinotecan hydrochloride2009
- Author(s)
  Akagi T., Fukagawa T., Kage Y., To H., Matsunaga N., Koyanagi S., Uchida A., Fujii A., Iba H., Ikemura T., Aramaki H., Higuchi S., Ohdo S.
- Journal Title
  
  J.Pharmacol.Sci. 109
  
  Pages: 265-274
- NAID
  10025734592
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20014019
[Journal Article] Influence of dosing schedules on toxicity and antitumour effects of combined cisnlatin and docetaxel treatment in mice2009
- Author(s)
  Kodama A., To H., Kinoshita T., Ieiri I., Higuchi S.
- Journal Title
  
  J. Pharm. Pharmacol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20014019
[Journal Article] Chronotherapy of Adriamycin in Japanese Outpatients with Mammary Cancer2005
- Author(s)
  To H., Saito T., Ohdo S., Higuchi S., Fujimura A., Kobayashi E.
- Journal Title
  
  Drug in R&D 6
  
  Pages: 101-107
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390159
[Journal Article] Therapeutic index by combination of adriamycin and docetaxel depends on dosing time in mice2005
- Author(s)
  Tabuchi M., To H., Sakaguchi H., Goto N., Takeuchi A., Higuchi S., Ohdo S.
- Journal Title
  
  Cancer Res. 65
  
  Pages: 8448-8454
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390159
[Journal Article] Chronotherapy of Irinotecan.2005
- Author(s)
  Qin T, Goto N, To H, Tsuruta K, Ohdo S, Higuchi S.
- Journal Title
  
  The Japanese Journal of Therapeutic Drug Monitoring 22
  
  Pages: 171-172
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390159
[Presentation] DocetaxelのCeruloplasmin増加作用によるAdriamycin誘発心毒性軽減の機序解明2009
- Author(s)
  友成真理、藤秀人、大戸茂弘、樋口駿、佐々木均
- Organizer
  第3回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-20014019

1. OHDO Shigehiro (00223884)

# of Collaborated Projects: 10 results

# of Collaborated Products: 3 results
2. TO Hideto (90346809)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
3. IEIRI Ichiro (60253473)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. HAMASE Hamase (10284522)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. UEZONO Keio (00168618)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. SAWADA Yasufumi (80114502)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. ZAITSU Kiyoshi (70091329)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. HIROTA Takeshi (80423573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. IGA Tatsuji (60012663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ORII Takao (50231246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SATO Hitoshi (40187224)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NAKANO Shigeyuki (10033341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MAEDA Minoru (70101178)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TAKANAGA Hitomi (20284523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MATSUO Hirotami (60274479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. OTSUBO Kenji (80260701)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. FUKUOKA Hideoki (80111540)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 田中雅夫 (30163570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 赤澤宏平 (10175771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 小川芳明 (60260709)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 吉田順一 (40253439)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 大江和彦 (40221121)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. ANAI Motoaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. URAE Akinori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. KANDA Taketoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 竹田虎彦

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HIGUCHI Shun 樋口 駿

樋口 駿 ヒグチ シュン

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Principal Investigator

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Alternative mechanisms of gene regulation for pharmacokinetics related genesPrincipal Investigator

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抗腫瘍効果に及ぼす腫瘍組織中トランスポーター発現の日周リズムPrincipal Investigator

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Construction of optimal combined chemotherapy of anti-tumor drugs based on chronotherapyPrincipal Investigator

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Study for cancer chronotherapy based on clock genePrincipal Investigator

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ABCトランスポーター遺伝子の多型解析と臨床意義の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

HIGUCHI Shun 樋口駿

樋口駿ヒグチシュン