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Saito Hideyuki  齋藤 秀之

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… Alternative Names

SAITO Hideyuki  齋藤 秀之

斉藤 秀之  サイトウ ヒデユキ

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Researcher Number 40225727
Other IDs
Affiliation (based on the past Project Information) *help 2019 – 2024: 熊本大学, 病院, 教授
2013 – 2018: 熊本大学, 医学部附属病院, 教授
2002 – 2011: 熊本大学, 医学部附属病院, 教授
2008: 熊本大学, 医学部・附属病院, 教授
2005: 熊本大学, 医学部付属病院, 教授 … More
2002: 熊本大学, 医学部, 教授
2000 – 2001: Kyoto University, Graduate School of Medicine, Associate Professor, 医学研究科, 助教授
1999: Graduate School of Medicine, KYOTO UNIVERSITY, Lecturer, 医学研究科, 講師
1999: 京都大学, 大学院・医学研究科, 講師
1997: 京都大学, 大学院・医学研究科, 講師
1996 – 1997: Graduate School of Medicine, Kyoto University Lecturer, 医学研究科, 講師
1995: Kyoto University, Department of Pharmacy, Instructor, 医学研究科, 助手
1994: 京都大学, 医学部, 助手
1990 – 1993: Tokyo Medical and Dental University, School of Medicine, Department of Hospital, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Medical pharmacy / Applied pharmacology / 医薬分子機能学 / Biological pharmacy / Basic Section 47060:Clinical pharmacy-related / 応用薬理学・医療系薬学
Except Principal Investigator
Biological pharmacy / 応用薬理学・医療系薬学 / Medical pharmacy / 医薬分子機能学 / Basic Section 47060:Clinical pharmacy-related / Physical pharmacy
Keywords
Principal Investigator
尿毒症物質 / 急性腎障害 / 硫酸転移酵素 / インドキシル硫酸 / 腎障害 / 薬物トランスポータ / ペプチドトランスポータ / 腎排泄 / 遺伝子発現 / 腎不全 … More / 代謝スクリーニング / 薬物動態 / 慢性腎不全 / シスプラチン / 薬物排泄 / 腎尿細管 / 薬剤性腎障害 / 有機アニオン / 尿細管分泌 / β-ラクタム抗生物質 / 腸管吸収 / 薬物輸送 / 間質線維化 / 間質性線維化 / 尿管結紮 / 心腎連関 / 腎線維化 / 慢性腎臓病 / 治療薬開発 / 活性酸素種 / シスプラチン腎症 / Renal failure / Dosage regimen / Nephrotoxicity / Renal tubular dysfunction / Renal excretion / Drug transporter / カチオン性薬物 / アニオン性薬物 / 投与設計 / 有機カチオン / 薬物投与設計 / 尿細管障害 / GENE EXPRESSION / PHARMACOKINETICS / RENAL FAILURE / ORGANIC IONS / RENAL EXCRETION / DRUG TRANSPORTER / 賢排泄 / 有機イオン / 腎排泄物 / 人工多能性幹細胞 / ヒト肝細胞 / iPS / iPS細胞 / 肝細胞 / 代謝スクリーニング系 / 腎臓病 / 虚血 / 酸化ストレス / 腎虚血 / 抗癌薬 / 遺伝子導入 / 尿細管再吸収 / クローニング / ジペプチド / 冊子縁膜 / 腎尿細胞 / 小腸 / βラクタム抗生物質 / 薬物吸収 / cDNAクローニング … More
Except Principal Investigator
尿細管分泌 / 有機カチオン / ペプチドトランスポータ / 腸管吸収 / ジペプチド / 有機カチオントランスポータ / 有機アニオントランスポータ / 培養上皮細胞 / 経細胞輸送 / 輸送担体 / 薬物輸送 / 有機アニオン / 刷子縁膜 / Intestinal Absorption / LLC-PK_1 / 卵母細胞 / プロトン共役輸送 / 小腸上皮細胞 / 薬物相互作用 / P-glycoprotein / テトラエチルアンモニウム / P-糖タンパク質 / Organic cation transporter / Organic anion transporter / Drug transport / Peptide transporter / Caco-2 / クローニング / cDNAクローニング / β-ラクタム抗生物質 / Proton-Coupled Transport / Dipeptide / Transcellular Transport / Cultured Epithelial Cell / Organic Cation / Tubular Secretion / セファロスポリン系抗生物質 / オーダーメード医療 / P-糖蛋白質 / 薬物トランスポータ / 薬物送達システム / 腎尿細管上皮細胞 / 薬剤感受性 / 分子標的治療薬 / 個別化医療 / CYLD / pharmacokinetics / therapeutic drug monitoring / amurubicinol / amurubic in / ファーマコダイナミクス / 個別化 / 薬剤耐性 / 細胞膜輸送 / ファーマコキネティクス / 血中濃度モニタリング / アムルビシノール / アムルビシン / Organic ion / Renal excretion / Detoxification system / Expression profile / Genetic polymorphism / Interindividual differences / Personalized pharmacotherapy / Drug transporter / 遺伝子発現 / 薬物動態 / 腎疾患 / ペプチド類似薬物 / カチオン性薬物 / アニオン性薬物 / オーダーメイド薬物療法 / 有機イオン / 腎排泄 / 解毒システム / 発現プロファイル / 遺伝子多型 / 固体間変動 / テーラーメイド薬物療法 / Drug interaction / Tubular secretion / Excretion / Kidney / 3級アミン交換輸送系 / H^+ / 性差 / CaCo^2細胞 / 排泄 / 腎臓 / cDNA cloning / Xenopus oocyte / transfection / organic cation transporter / organic ahion transporter / tubular secretion / drug transport / メトトレキセート / 動物細胞安定発現系 / アフリカメガユル卵母細胞 / P・糖タンパク質 / アフリカツメガエル卵母細胞 / トランスフェクション / 有機カテオントランスポータ / Nonsteroidal anti-inflammatory drugs / Histidine tesidue / beta-L actam antibiotics / Stable transfectant / β-ランタム抗生物質 / 非ステロイド抗炎症薬 / ヒスチジン残基 / 安定発現系 / Kinetic analysis / Renal toxicity / Transcellular transport / beta-Lactam antibiotics / Cultured cells / LLC-PK_<1-> / 速度論的解析 / 腎毒性 / β-ラクタム系抗生物質 / ペプチド輸送系 / 培養細胞 / cDNA Cloning / Organic Anions / Renal Tubular Secretion / Peptide Transporter / beta-Lactam Antibiotics / Drug Transport / セファロスポリン / Cephalosporin Antibiotic / アミノ-β-ラクタム抗生物質 / Transporter / Renal Epithelial Cell / Intestinal Epithelial Cell / 吸収・分泌 / Dipeptide Transport System / betaーLactam Antibiotic / Organic Anion / Membrane vesicle / BrushーBorder Membrane / ピリドンカルボン酸系抗菌剤 / βーラクタム抗性物質 / ジペプチド輸送系 / βーラクタム抗生物質 / 膜小胞系 / 薬剤反応性 / 癌 / 分子標的薬 / 薬理遺伝学 / 抗悪性腫瘍薬 / 個別投与設計 / 発現調節 / 転写調節 / 薬物体内動態 / トランスポータ / 側底膜 / 薬物認識 / 頂側膜酵素 / DNA断片化 / 細胞障害 / ネクローシス / アポトーシス / シスプラチン / 薬剤性腎障害 / PCRクローニング Less
  • Research Projects

    (31 results)
  • Research Products

    (208 results)
  • Co-Researchers

    (33 People)
  •  Investigation of the toxicological role of indoxyl sulfate and the enzyme responsible for its production, Sult1a1, in the cardiorenal syndromePrincipal Investigator

    • Principal Investigator
      齋藤 秀之
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kumamoto University
  •  Establishing novel molecular-targeted cancer therapies based on molecular diagnostics focusing on prognostic factor CYLD

    • Principal Investigator
      Jono Hirofumi
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kumamoto University
  •  Search for uremia suppressive therapeutics based on investigation on role of sulfate-conjugated uremic solutes in development and pregoression of kidney injuryPrincipal Investigator

    • Principal Investigator
      SAITO HIDEYUKI
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied pharmacology
    • Research Institution
      Kumamoto University
  •  Development of renoprotective and uremia therapeutic drug seeds based on inhibition of hepatic production of sulfate-conjugated uremic solutesPrincipal Investigator

    • Principal Investigator
      Saito Hideyuki
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Kumamoto University
  •  Establishment of hepatocyte model from induced pluripotent stem (iPS) cells for exploring uremic toxin production inhibitorsPrincipal Investigator

    • Principal Investigator
      Saito Hideyuki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Kumamoto University
  •  Novel strategy for development of suppressive drugs for kidney disease based on inhibition of metabolic production of uremic toxinsPrincipal Investigator

    • Principal Investigator
      SAITO Hideyuki
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Kumamoto University
  •  Development of personalized medicine for cancer chemotherapy according to a variety of sensitivity and pharmacokinetics

    • Principal Investigator
      HAMADA Akinobu
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Kumamoto University
  •  Development of an individualized therapy for establishing the optimal dosage by analysis of pharmacological gene

    • Principal Investigator
      HAMADA Akinobu
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Kumamoto University
  •  Strategy for protection of kidney injury based on functioal relation betwee renal specific stress response mechanisms and xenobiotic detoxication systemsPrincipal Investigator

    • Principal Investigator
      SAITO Hideyuki
    • Project Period (FY)
      2005 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied pharmacology
    • Research Institution
      Kumamoto University
  •  Development of dosage individualization of anti-tumor drugs based on therapeutic drug monitoring and pharmacokinetic-related gene expression

    • Principal Investigator
      MATSUMOTO Mitsuhiro
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Kumamoto University
  •  薬物トランスポータの発現量変動評価系の構築-薬物体内動態制御薬の開発へ向けて

    • Principal Investigator
      乾 賢一
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      医薬分子機能学
    • Research Institution
      Kyoto University
  •  Molecular Biological Studies on Relationships between Changes in Renal Tubular Transporter Gene Expressions and Deterioration of Drug Excretory Functions in Renal DiseasesPrincipal Investigator

    • Principal Investigator
      SAITO Hideyuki
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Kumamoto University
  •  Evaluation of drug interaction and interindividual differences of renal drug excretion based on the genetic polymorphism analysis

    • Principal Investigator
      INUI Ken-ichi
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      KYOTO UNIVERSTTY
  •  薬物トランスポータの分子認識能に基づく薬物分子設計

    • Principal Investigator
      乾 賢一
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyoto University
  •  MOLECULAR ANALYSIS OF CORRELATION BEIWEEN ALTERATIONS IN XENOBIOTIC TRANSPORTER EXPRESSIONS AND ATTENUATED DRUG EXCRETION IN RENAL FAILUREPrincipal Investigator

    • Principal Investigator
      SAITO Hideyuki
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      KYOTO UNIVERSITY
  •  薬物トランスポータ分子認識を利用した薬物動態制御システムの構築

    • Principal Investigator
      乾 賢一
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyoto University
  •  Molecular diversity of organic ion transporters and their roles in the renal drug excretion

    • Principal Investigator
      INUI Ken-ichi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      医薬分子機能学
    • Research Institution
      KYOTO UNIVERSITY
  •  ペプチドトランスポータ遺伝子導入安定発現系の確立に基づく薬物認識機構の分子的解明Principal Investigator

    • Principal Investigator
      斉藤 秀之
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      医薬分子機能学
    • Research Institution
      Kyoto University
  •  薬剤性腎障害発現におけるアポトーシスの役割に関する研究

    • Principal Investigator
      乾 賢一
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Biological pharmacy
    • Research Institution
      Kyoto University
  •  Development of novel systems for evaluation and prediction of drug inteactions based on the reconstruction of drug excretion systems in vitro.

    • Principal Investigator
      INUI Ken-ichi
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      KYOTO UNIVERSITY
  •  プロトン駆動型ペプチド輸送体の臓器分布特性と基算認識機構に関する分子生物学的解析Principal Investigator

    • Principal Investigator
      齋藤 秀之
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      Kyoto University
  •  Molucular analysis of tissue distribution and structure-function relationship of transporters responsible for the regulation of drug transport

    • Principal Investigator
      INUI Ken-ichi
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      KYOTO UNIVERSITY
  •  PCR法及び外来遺伝子発現系による薬物トランスポータ群の構造・機能解析Principal Investigator

    • Principal Investigator
      齋藤 秀之
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      Kyoto University
  •  Kietic analysis and evaluation of drug absorption and excretion using cultured cells.

    • Principal Investigator
      INUI Ken-ichi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      KYOTO UNIVERSITY
  •  Molecular and Cell Biological Analyzes of Structure and Function of Drug Transporters in the Intestine and Kidney Proximal Tubule

    • Principal Investigator
      INUI Ken-ichi
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      KYOTO UNIVERSITY
  •  小腸及び腎尿細管上皮細胞における薬物輸送体の分子生物学的研究

    • Principal Investigator
      乾 賢一
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Tokyo Medical and Dental University
  •  小腸及び腎尿細管におけるプロトン共役薬物輸送担体の発現と調節

    • Principal Investigator
      INUI Kenーichi
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  小腸及び腎尿細管上皮細胞における薬物輸送担体の構造と機能に関する研究

    • Principal Investigator
      乾 賢一
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Tokyo Medical and Dental University
  •  The Use of Cultured Cells for Alternatives to Animal Experiments in Drag Absorption and Secretion

    • Principal Investigator
      INUI Kenichi
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tokyo Medical and Dental University
  •  Structure and Function of Drug Transporters in the Intestinal and Renal Epithelial Cells

    • Principal Investigator
      INUI Ken-ichi
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Tokyo Medical and Dental University
  •  In Vitro New Evaluation Method for the Drug Absorption and Secretion Using Membrane Vesicles

    • Principal Investigator
      INUI Kenーichi
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B).
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tokyo Medical and Dental University
      Kyoto University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book Patent Other

  • [Book] くすりがわかる 作用機序×使い方×観察・ケア2023

    • Author(s)
      柳田 俊彦、武田 泰生、齋藤秀之、伊東 弘樹、池田 龍二
    • Total Pages
      452
    • Publisher
      南山堂
    • ISBN
      9784525500719
    • Data Source
      KAKENHI-PROJECT-23K24047
  • [Book] Uremic Toxins and Organ Failure2020

    • Author(s)
      Hideyuki Saito, Takaaki Abe
    • Total Pages
      180
    • Publisher
      Springer Nature
    • Data Source
      KAKENHI-PROJECT-17H04104
  • [Book] 腎と透析増刊号・腎と透析ベッドサイド検査事典2018

    • Author(s)
      齋藤秀之
    • Total Pages
      471
    • Publisher
      東京医学社
    • Data Source
      KAKENHI-PROJECT-17H04104
  • [Book] Annual Review腎臓20162016

    • Author(s)
      齋藤秀之
    • Total Pages
      206
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Book] 月刊『腎臓内科・泌尿器科』, シスプラチン腎障害 - 最近の話題2016

    • Author(s)
      藤野梨香、城野博史、齋藤秀之
    • Total Pages
      518
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Book] 薬局:併病/多病のケースで考える・薬学的管理における処方箋検査値の活用術!「慢性腎臓病×脂質異常症×脳梗塞」2016

    • Author(s)
      齋藤秀之
    • Total Pages
      161
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Book] 月刊「細胞」Topics from special edition2016

    • Author(s)
      齋藤秀之
    • Total Pages
      55
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-25670080
  • [Book] 月刊「細胞」特集:急性腎障害のブレークスルーを求めて2016

    • Author(s)
      齋藤秀之
    • Total Pages
      55
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Book] Annual Review腎臓2016:Basic nephrology・尿細管間質障害「1. 尿毒症物質と腎障害」2016

    • Author(s)
      齋藤秀之
    • Total Pages
      206
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Book] Annual Review腎臓20162015

    • Author(s)
      齋藤秀之
    • Total Pages
      206
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-25670080
  • [Book] 月刊薬事:尿毒症物質の臨床薬理2013

    • Author(s)
      齋藤秀之
    • Total Pages
      186
    • Publisher
      じほう
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Book] 腎臓病薬物療法・実践ガイド2013

    • Author(s)
      齋藤秀之
    • Total Pages
      458
    • Publisher
      中山書店
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Book] 月刊薬事:薬剤性腎障害のとらえ方「尿毒症物質の臨床薬理」2013

    • Author(s)
      齋藤秀之
    • Total Pages
      186
    • Publisher
      じほう
    • Data Source
      KAKENHI-PROJECT-25670080
  • [Book] 薬物トランスポータ活用ライブラリー:機能・輸送基質から創薬・臨床応用まで2009

    • Author(s)
      齋藤秀之, 他
    • Publisher
      洋土社
    • Data Source
      KAKENHI-PROJECT-21390048
  • [Book] 薬物トランスポーター活用ライブラリー:機能・輸送基質から創薬・臨床応用まで2009

    • Author(s)
      齋藤秀之, 他
    • Total Pages
      246
    • Publisher
      洋土社
    • Data Source
      KAKENHI-PROJECT-21390048
  • [Book] 腎機能を考えた安全な処方2006

    • Author(s)
      齋藤 秀之
    • Total Pages
      514
    • Publisher
      医薬ジャーナル社
    • Data Source
      KAKENHI-PROJECT-17390158
  • [Book] 医療薬学2005

    • Author(s)
      齋藤秀之
    • Total Pages
      419
    • Publisher
      廣川書店
    • Data Source
      KAKENHI-PROJECT-17390158
  • [Journal Article] Dose Individualization of Cefepime for Febrile Neutropenia in Patients With Lymphoma or Multiple Myeloma: Implications for Therapeutic Drug Monitoring2023

    • Author(s)
      Oda Kazutaka、Yamaguchi Ayami、Matsumoto Naoya、Nakata Hirotomo、Higuchi Yusuke、Nosaka Kisato、Jono Hirofumi、Saito Hideyuki
    • Journal Title

      Therapeutic Drug Monitoring

      Volume: 46 Pages: 80-88

    • DOI

      10.1097/ftd.0000000000001138

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K17467, KAKENHI-PROJECT-23K24047
  • [Journal Article] Model‐informed precision dosing of teicoplanin for the rapid achievement of the target area under the concentration‐time curve: A simulation study2023

    • Author(s)
      Oda Kazutaka、Yamada Tomoyuki、Matsumoto Kazuaki、Hanai Yuki、Ueda Takashi、Samura Masaru、Shigemi Akari、Jono Hirofumi、Saito Hideyuki、Kimura Toshimi
    • Journal Title

      Clinical and Translational Science

      Volume: 16 Issue: 4 Pages: 704-713

    • DOI

      10.1111/cts.13484

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K17467, KAKENHI-PROJECT-23K24047
  • [Journal Article] Wnt/β-catenin signaling is a novel therapeutic target for tumor suppressor CYLD-1silenced glioblastoma cells2023

    • Author(s)
      Kanemaru Ayumi、Ito Yuki、Yamaoka Michiko、Shirakawa Yuki、Yonemaru Kou、Miyake Shunsuke、Ando Misaki、Ota Masako、Masuda Takeshi、Mukasa Akitake、Li Jian-Dong、Saito Hideyuki、Hide Takuichiro、Jono Hirofumi
    • Journal Title

      Oncology Reports

      Volume: 50 Issue: 5 Pages: 1-12

    • DOI

      10.3892/or.2023.8638

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K15400, KAKENHI-PROJECT-22K20797, KAKENHI-PROJECT-20K09374, KAKENHI-PUBLICLY-22H05546, KAKENHI-PROJECT-23K23867, KAKENHI-PROJECT-23K24047, KAKENHI-PROJECT-23K27345
  • [Journal Article] Suppression of Indoxyl Sulfate Accumulation Reduces Renal Fibrosis in Sulfotransferase 1a1-Deficient Mice2023

    • Author(s)
      Hou Huixian、Horikawa Mai、Narita Yuki、Jono Hirofumi、Kakizoe Yutaka、Izumi Yuichiro、Kuwabara Takashige、Mukoyama Masashi、Saito Hideyuki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Issue: 14 Pages: 11329-11329

    • DOI

      10.3390/ijms241411329

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K18291, KAKENHI-PROJECT-22K08357, KAKENHI-PROJECT-23K06281, KAKENHI-PROJECT-23K07676, KAKENHI-PROJECT-21K08280, KAKENHI-PROJECT-23K24047
  • [Journal Article] Model-Informed Precision Dosing of Vancomycin in Adult Patients Undergoing Hemodialysis2023

    • Author(s)
      Oda Kazutaka、Jono Hirofumi、Saito Hideyuki
    • Journal Title

      Antimicrobial Agents and Chemotherapy

      Volume: 67 Issue: 6

    • DOI

      10.1128/aac.00089-23

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K17467, KAKENHI-PROJECT-23K24047
  • [Journal Article] Population Pharmacokinetics and AUC-Guided Dosing of Tobramycin in the Treatment of Infections Caused by Glucose-Nonfermenting Gram-Negative Bacteria2023

    • Author(s)
      Hashiguchi Yumi、Matsumoto Naoya、Oda Kazutaka、Jono Hirofumi、Saito Hideyuki
    • Journal Title

      Clinical Therapeutics

      Volume: 45 Issue: 5 Pages: 400-414.e2

    • DOI

      10.1016/j.clinthera.2023.03.015

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K17467, KAKENHI-PROJECT-23K24047
  • [Journal Article] Bayesian prediction-based individualized dosing of anti-methicillin-resistant Staphylococcus aureus treatment: Recent advancements and prospects in therapeutic drug monitoring2023

    • Author(s)
      Oda Kazutaka、Saito Hideyuki、Jono Hirofumi
    • Journal Title

      Pharmacology &amp; Therapeutics

      Volume: 246 Pages: 108433-108433

    • DOI

      10.1016/j.pharmthera.2023.108433

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K17467, KAKENHI-PROJECT-23K24047
  • [Journal Article] Potential use of EGFR-targeted molecular therapies for tumor suppressor CYLD-negative and poor prognosis oral squamous cell carcinoma with chemoresistance2022

    • Author(s)
      Kanemaru Ayumi、Shinriki Satoru、Kai Mimi、Tsurekawa Kanae、Ozeki Kazuya、Uchino Shota、Suenaga Naoki、Yonemaru Kou、Miyake Shunsuke、Masuda Takeshi、Kariya Ryusho、Okada Seiji、Takeshita Hisashi、Seki Yuki、Yano Hiromu、Komohara Yoshihiro、Yoshida Ryoji、Nakayama Hideki、Li Jian-Dong、Saito Hideyuki、Jono Hirofumi
    • Journal Title

      Cancer Cell International

      Volume: 22 Issue: 1 Pages: 358-358

    • DOI

      10.1186/s12935-022-02781-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K10195, KAKENHI-PROJECT-23K24047
  • [Journal Article] A novel step‐down infusion method of barbiturate therapy: Its safety and effectiveness for intracranial pressure control2021

    • Author(s)
      Yamakawa Yukako、Morioka Motohiro、Negoto Tetsuya、Orito Kimihiko、Yoshitomi Munetake、Nakamura Yukihiko、Takeshige Nobuyuki、Yamamoto Masafumi、Takeuchi Yasuharu、Oda Kazutaka、Jono Hirofumi、Saito Hideyuki
    • Journal Title

      Pharmacology Research & Perspectives

      Volume: 9 Issue: 2

    • DOI

      10.1002/prp2.719

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04104, KAKENHI-PROJECT-18K08955, KAKENHI-PROJECT-21K09193
  • [Journal Article] Suppressed Hepatic Production of Indoxyl Sulfate Attenuates Cisplatin-Induced Acute Kidney Injury in Sulfotransferase 1a1-Deficient Mice2021

    • Author(s)
      Yabuuchi Nozomi、Hou Huixian、Gunda Nao、Narita Yuki、Jono Hirofumi、Saito Hideyuki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 4 Pages: 1764-1764

    • DOI

      10.3390/ijms22041764

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04104
  • [Journal Article] CYLD: a novel stratification marker for malignant tumors2021

    • Author(s)
      Shunsuke Miyake, Ayumi Kanemaru, Hideyuki Saito, Hirofumi Jono
    • Journal Title

      Journal of Asian Association of Schools of Pharmacy

      Volume: 10 Pages: 17-22

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Journal Article] Glioma Cells Acquire Stem-like Characters by Extrinsic Ribosome Stimuli2021

    • Author(s)
      Shirakawa Yuki、Ohta Kunimasa、Miyake Shunsuke、Kanemaru Ayumi、Kuwano Akari、Yonemaru Kou、Uchino Shota、Yamaoka Michiko、Ito Yuki、Ito Naofumi、Hide Takuichiro、Shinojima Naoki、Mukasa Akitake、Saito Hideyuki、Jono Hirofumi
    • Journal Title

      Cells

      Volume: 10 Issue: 11 Pages: 2970-2970

    • DOI

      10.3390/cells10112970

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02591, KAKENHI-PROJECT-19H03235, KAKENHI-PROJECT-20K09374, KAKENHI-PROJECT-20H03792
  • [Journal Article] Comparative Study of Constipation Exacerbation by Potassium Binders Using a Loperamide-Induced Constipation Model2020

    • Author(s)
      Narita Yuki、Fukumoto Koichi、Fukunaga Masaki、Kondo Yuki、Ishitsuka Yoichi、Jono Hirofumi、Irie Tetsumi、Saito Hideyuki、Kadowaki Daisuke、Hirata Sumio
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 7 Pages: 2491-2491

    • DOI

      10.3390/ijms21072491

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04104, KAKENHI-PROJECT-18K06774
  • [Journal Article] Relationship between clinicopathological characteristics and CYLD expression in patients with cholesteatoma.2020

    • Author(s)
      Miyake S, Miwa T, Yoneda G, Kanemaru A, Saito H, Minoda R, Orita Y, Saito H, Jono H.
    • Journal Title

      PLoS One

      Volume: 15

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Journal Article] Ribosomal protein S6 promotes stem‐like characters in glioma cells2020

    • Author(s)
      Shirakawa Yuki、Hide Takuichiro、Yamaoka Michiko、Ito Yuki、Ito Naofumi、Ohta Kunimasa、Shinojima Naoki、Mukasa Akitake、Saito Hideyuki、Jono Hirofumi
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 6 Pages: 2041-2051

    • DOI

      10.1111/cas.14399

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K09374, KAKENHI-PROJECT-17H04104, KAKENHI-PROJECT-18H02591, KAKENHI-PROJECT-19H03235, KAKENHI-PROJECT-20H03792
  • [Journal Article] Continuous high-dose infusion of doripenem in a pneumonia patient infected by carbapenem-resistant Pseudomonas aeruginosa: a case report2019

    • Author(s)
      Oda K, Kamohara H, Katanoda T, Hashiguchi Y, Iwamura K, Nosaka K, Jono H, Saito H.
    • Journal Title

      J Pharm Health Care Sci.

      Volume: 5 Pages: 1-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04104
  • [Journal Article] Establishing individualized medicine for intractable cancer based on clinical molecular pathogenesis -A novel predictive marker CYLD for molecular targeted therapies-2019

    • Author(s)
      Jono H, Saito H
    • Journal Title

      Proceedings for Annual Meeting of The Japanese Pharmacological Society

      Volume: 92 Issue: 0 Pages: 2-S15-4

    • DOI

      10.1254/jpssuppl.92.0_2-S15-4

    • NAID

      130007813106

    • ISSN
      2435-4953
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Journal Article] Loss of tumor suppressor CYLD expression triggers cisplatin resistance in oral squamous cell carcinoma.2019

    • Author(s)
      Suenaga N, Kuramitsu M, Komure K, Kanemaru A, Takano K, Ozeki K, Nishimura Y, Yoshida R, Nakayama H, Shinriki S, Saito H, Jono H.
    • Journal Title

      J Mol Sci

      Volume: 20 Issue: 20 Pages: 5194-5194

    • DOI

      10.3390/ijms20205194

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K10360, KAKENHI-PROJECT-17H04104, KAKENHI-PROJECT-18H02591
  • [Journal Article] Edoxaban Exerts Antioxidant Effects Through FXa Inhibition and Direct Radical-Scavenging Activity.2019

    • Author(s)
      Narita Y, Hamamura K, Kashiyama M, Utsumi S, Kakizoe Y, Kondo Y, Ishitsuka Y, Jono H, Irie T, Mukoyama M, Saito H, Kadowaki D, Hirata S, Kitamura K.
    • Journal Title

      Int J Mol Sci.

      Volume: 20

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04104
  • [Journal Article] Development and evaluation of a vancomycin dosing nomogram to achieve the target area under the concentration-time curve. A retrospective study.2019

    • Author(s)
      Oda K, Katanoda T, Hashiguchi Y, Kondo S, Narita Y, Iwamura K, Nosaka K, Jono H, Saito H
    • Journal Title

      J Infect Chemother.

      Volume: 26 Pages: 444-450

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04104
  • [Journal Article] Population Pharmacokinetics and Adverse Events of Erlotinib in Japanese Patients with Non-small-cell Lung Cancer: Impact of Genetic Polymorphisms in Metabolizing Enzymes and Transporters2018

    • Author(s)
      Endo-Tsukude C, Sasaki JI, Saeki S, Iwamoto N, Inaba M, Ushijima S, Kishi H, Fujii S, Semba H, Kashiwabara K, Tsubata Y, Hayashi M, Kai Y, Saito H, Isobe T, Kohrogi H, Hamada A.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 41 Issue: 1 Pages: 47-56

    • DOI

      10.1248/bpb.b17-00521

    • NAID

      130006301216

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04104
  • [Journal Article] Doxycycline attenuates cisplatin-induced acute kidney injury through pleiotropic effects.2018

    • Author(s)
      Nakagawa T, Kakizoe Y, Iwata Y, Miyasato Y, Mizumoto T, Adachi M, Izumi Y, Kuwabara T, Suenaga N, Narita Y, Jono H, Saito H, Kitamura K, Mukoyama M.
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: 315

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04104
  • [Journal Article] A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency.2017

    • Author(s)
      Aoki M, Hayashi H, Rao KV, Das D, Higashi-Kuwata N, Bulut H, Aoki-Ogata H, Takamatsu Y, Yedidi RS, Davis DA, Hattori SI, Nishida N, Hasegawa K, Takamune N, Nyalapatla PR, Osswald HL, Jono H, Saito H, Yarchoan R, Misumi S, Ghosh AK, Mitsuya H.
    • Journal Title

      Elife

      Volume: 6

    • DOI

      10.7554/elife.28020

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19577, KAKENHI-PROJECT-17K15710, KAKENHI-PROJECT-17H04104, KAKENHI-PROJECT-17H04222
  • [Journal Article] Nephropreventive Effect of Shikonin on Murine LPS-induced Septic Acute Kidney Injury via Nrf2 Activation with Antioxidative Responses.2016

    • Author(s)
      Madoka Kawara, Rika Matsunaga, Yuko Yamamoto, Go Yoneda, Rika Fujino, Hirofumi Jono, Hideyuki Saito.
    • Journal Title

      J Clin Exp Nephrol

      Volume: 1 Issue: 03 Pages: 19-24

    • DOI

      10.21767/2472-5056.100019

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Journal Article] Indoxyl Sulfate as a Mediator Involved in Dysregulation of Pulmonary Aquaporin-5 in Acute Lung Injury Caused by Acute Kidney Injury.2016

    • Author(s)
      Yabuuchi N, Sagata M, Saigo C, Yoneda G, Yamamoto Y, Nomura Y, Nishi K, Fujino R, Jono H, Saito H.
    • Journal Title

      Int J Mol Sci

      Volume: 18 Issue: 1 Pages: 11-11

    • DOI

      10.3390/ijms18010011

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Journal Article] Effect of administration duration of low dose Methotrexate on development of acute kidney injury in rats.2016

    • Author(s)
      Li X, Abe E, Yamakawa Y, Yoneda G, Fujino R, Yamashita M, Iida Y, Jono H, Saito H
    • Journal Title

      Journal of Kidney

      Volume: 2 Issue: 3

    • DOI

      10.4172/2472-1220.1000130

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Journal Article] Phase I and pharmacokinetic study of erlotinib administered in combination with amrubicin in patients with previously treated, advanced non-small cell lung cancer.2015

    • Author(s)
      Otani S, Hamada A, Sasaki J, Wada M, Yamamoto M, Ryuge S, Takakura A, Fukui T, Yokoba M, Mitsufuji H, Toyooka I, Maki S, Kimura M, Hayashi N, Ishihara M, Kasajima M, Hiyoshi Y, Katono K, Asakuma M, Igawa S, Kubota M, Katagiri M, Saito H, Masuda N.
    • Journal Title

      Am J Clin Oncol.

      Volume: 38 Issue: 4 Pages: 405-410

    • DOI

      10.1097/coc.0b013e3182a2d98d

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25670080, KAKENHI-PROJECT-25293040
  • [Journal Article] Meclofenamate elicits a nephropreventing effect in a rat model of ischemic acute kidney injury by suppressing indoxyl sulfate production and restoring renal organic anion transporters.2014

    • Author(s)
      Saigo C, Nomura Y, Yamamoto Y, Sagata M, Matsunaga R, Jono H, Nishi K, Saito H.
    • Journal Title

      Drug Des. Devel. Ther.

      Volume: 8 Pages: 1073-1082

    • DOI

      10.2147/dddt.s67456

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293040, KAKENHI-PROJECT-25670080
  • [Journal Article] Distinct interaction of nilotinib and imatinib with P-Glycoprotein in intracellular accumulation and cytotoxicity in CML Cell Line K562 cells.2014

    • Author(s)
      Yamakawa Y, Hamada A, Uchida T, Sato D, Yuki M, Hayashi M, Kawaguchi T, Saito H.
    • Journal Title

      Biol Pharm Bull.

      Volume: 37 Pages: 1330-1335

    • NAID

      130004677542

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670080
  • [Journal Article] Carbamazepine-imatinib interaction in a child with chronic myeloid leukemia.2014

    • Author(s)
      Taguchi K, Kouroki M, Ohmura T, Jono H, Endo F, Saito H.
    • Journal Title

      Pediatr Int.

      Volume: 56

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670080
  • [Journal Article] False tacrolimus concentrations measured by antibody-conjugated magnetic immunoassay in liver transplant patient: 2 case reports and literature review.2014

    • Author(s)
      Taguchi K, Ohmura T, Ohya Y, Horio M, Furukawa K, Jono H, Inomata Y, Saito H.
    • Journal Title

      Exp. Clin. Transplant.

      Volume: 12 Pages: 474-478

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Journal Article] Hepatic sulfotransferase as a nephropreventing target by suppression of the uremic toxin indoxyl sulfate accumulation in ischemic acute kidney injury.2014

    • Author(s)
      Saito H, Yoshimura M, Saigo C, Komori M, Nomura Y, Yamamoto Y, Sagata M, Wakida A, Chuman E, Nishi K, Jono H.
    • Journal Title

      Toxicol. Sci.

      Volume: 141 Issue: 1 Pages: 206-217

    • DOI

      10.1093/toxsci/kfu119

    • NAID

      120005663611

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293040, KAKENHI-PROJECT-25670080
  • [Journal Article] Distinct interaction of nilotinib and imatinib with P-Glycoprotein in intracellular accumulation and cytotoxicity in CML Cell Line K562 cells.2014

    • Author(s)
      Yamakawa Y, Hamada A, Uchida T, Sato D, Yuki M, Hayashi M, Kawaguchi T, Saito H.
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 37 Pages: 1330-1335

    • NAID

      130004677542

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Journal Article] Carbamazepine-imatinib interaction in a child with chronic myeloid leukemia.2014

    • Author(s)
      Taguchi K, Kouroki M, Ohmura T, Jono H, Endo F, Saito H.
    • Journal Title

      Pediatr. Int.

      Volume: 56 Issue: 4

    • DOI

      10.1111/ped.12382

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25293040, KAKENHI-PROJECT-26713006
  • [Journal Article] Effects of Atrial Natriuretic Peptide on Bicarbonate Transport in Long- and Short-Looped Medullary Thick Ascending Limbs of Rats.2013

    • Author(s)
      Hiroshi Nonoguchi, Yuichiro Izumi, Yushi Nakayama, Takanobu Matsuzaki , Yukiko Yasuoka, Takeaki Inoue, Hideaki Inoue, Tomohiko Mouri, Katsumasa Kawahara, Hideyuki Saito, Kimio Tomita.
    • Journal Title

      PLOS one.

      Volume: 8 Issue: 12 Pages: e83146-e83146

    • DOI

      10.1371/journal.pone.0083146

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591224, KAKENHI-PROJECT-24591244, KAKENHI-PROJECT-24790222, KAKENHI-PROJECT-25293040
  • [Journal Article] Toxico-pharmacological perspective of the Nrf2-Keap1 defense system against oxidative stress in kidney diseases.2013

    • Author(s)
      Saito H
    • Journal Title

      Biochemical Pharmacology

      Volume: 85 Issue: 7 Pages: 221-227

    • DOI

      10.1016/j.bcp.2013.01.006

    • NAID

      120005254880

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Journal Article] Effects of genetic variants in SLC22A2 organic cation transporter2and SLC47A1 multidrug and toxin extrusion1transporter on cisplatin-induced adverse events2012

    • Author(s)
      Iwata K, Aizawa K, Kamitsu S, Ji ngami S, Fukunaga E, Yoshida M, Yoshimura M, Hamada A, Saito H
    • Journal Title

      Clin Exp Nephrol

      Volume: (accepted)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590167
  • [Journal Article] Effects of Genetic Variants in SLC22A2 Organic Cation Transporter 2 and SLC47A1 Multidrug and Toxin Extrusion 1 Transporter on Cisplatin-induced Adverse Events2012

    • Author(s)
      Iwata K, Aizawa K, Kamitsu S, Jingami S, Fukunaga E, Yoshida M, Yoshimura M, Hamada A, Saito H
    • Journal Title

      Clin Exp Nephrol

      Volume: (in press)

    • NAID

      10031145916

    • Data Source
      KAKENHI-PROJECT-21390048
  • [Journal Article] Genetic polymorphisms in metabolic and cellular transport pathway of methotrexate impact clinical outcome of methotrexate monotherapy in Japanese patients with rheumatoid arthritis2012

    • Author(s)
      Kato T, Hamada A, Mori S, Saito H
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: (in press)

    • NAID

      130004463237

    • Data Source
      KAKENHI-PROJECT-21390048
  • [Journal Article] Association of ABCB1 polymorphisms with erlotinib pharmacokinetics and toxicity in Japanese patients with non-small cell lung cancer2012

    • Author(s)
      Hamada A, Sasaki J, Saeki S, Iwamoto N, Inaba M, Ushijima S, Urata M, Kishi H, Fujii S, Semba H, Kashiwabara K, Tsubata Y, Kai Y, Isobe T, Kourogi H, Saito H
    • Journal Title

      Pharmacogenomics

      Volume: 13 Pages: 615-624

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590167
  • [Journal Article] The relationship between treatment time of gemcitabine and development of hematologic toxicity in cancer patients2011

    • Author(s)
      Iwata K, Aizawa K, Sakai S, Jingami S, Fukunaga E, Yoshida M, Hamada A, Saito H
    • Journal Title

      Biol Pharm Bull

      Volume: 34(11) Pages: 1765-1768

    • NAID

      130001252863

    • Data Source
      KAKENHI-PROJECT-21390048
  • [Journal Article] High-performance liquid chromatographic assay for the determination of nilotinib in human plasma2011

    • Author(s)
      Yuki M, Yamakawa Y, Uchida T, Nambu T, Kawaguchi T, Hamada A, Saito H
    • Journal Title

      Biol Pharm Bull

      Volume: 34(7) Pages: 1126-1128

    • NAID

      130000738108

    • Data Source
      KAKENHI-PROJECT-21390048
  • [Journal Article] Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia2011

    • Author(s)
      Yamakawa Y, Hamada A, Nakashima R, Yuki M, Hirayama C, Kawaguchi T, Saito H
    • Journal Title

      Ther Drug Monit

      Volume: 33 Pages: 244-250

    • NAID

      120005952466

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590167
  • [Journal Article] Association of SLCO1B3 polymorphism with intracellular accumulation of imatinib in leukocytes in patients with chronic myeloid leukemia2011

    • Author(s)
      Nambu T, Hamada A, Nakashima R, Yuki M, Kawaguchi T, Mitsuya H, Saito H
    • Journal Title

      Biol Pharm Bull

      Volume: 34(1) Pages: 114-119

    • NAID

      130000402273

    • Data Source
      KAKENHI-PROJECT-21390048
  • [Journal Article] Association of SLCO1B3 polymorphism with intracellular accumulation of imatinib in leukocytes in patients with chronic myeloid leukemia2011

    • Author(s)
      Nambu T, Hamada A, Nakashima R, Yuki M, Kawaguchi T, Mitsuya H, Saito H
    • Journal Title

      Biol Pharm Bull

      Volume: 34 Pages: 114-119

    • NAID

      130000402273

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590167
  • [Journal Article] Pharmacokinetic impact of SLCO1A2 polymorphisms on imatinib disposition in patients with chronic myeloid leukemia2011

    • Author(s)
      Yamakawa Y, Hamada A, Shuto T, Yuki M, Uchida T, Kai H, Kawaguchi T, Saito H
    • Journal Title

      Clin Pharmacol Ther

      Volume: 90(1) Pages: 157-163

    • NAID

      120005952465

    • URL

      http://hdl.handle.net/2298/23261

    • Data Source
      KAKENHI-PROJECT-21390048
  • [Journal Article] High-performance liquid chromatographic assay for the determination of nilotinib in human plasma2011

    • Author(s)
      Yuki M, Yamakawa Y, Uchida T, Nambu T, Kawaguchi T, Hamada A, Saito H
    • Journal Title

      Biol Pharm Bull

      Volume: 34 Pages: 1126-1128

    • NAID

      130000738108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590167
  • [Journal Article] Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia2011

    • Author(s)
      Yamakawa Y, Hamada A, Nakashima R, Yuki M, Hirayama C, Kawaguchi T, Saito H
    • Journal Title

      Ther Drug Monit

      Volume: 33(2) Pages: 244-250

    • NAID

      120005952466

    • Data Source
      KAKENHI-PROJECT-21390048
  • [Journal Article] Pharmacokinetic impact of SLCO1A2 polymorphisms on imatinib disposition in patients with chronic myeloid leukemia2011

    • Author(s)
      Yamakawa Y, Hamada A, Shuto T, Yuki M, Uchida T, Kai H, Kawaguchi T, Saito H
    • Journal Title

      Clin Pharmacol Ther

      Volume: 90 Pages: 157-163

    • NAID

      120005952465

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590167
  • [Journal Article] Alleviation of cisplatin-induced acute kidney injury using phytochemical polyphenols is accompanied by reduced accumulation of indoxyl sulfate in rats2011

    • Author(s)
      Kusumoto M, Kamobayashi H, Sato D, Komori M, Yoshimura M, Hamada A, Kohda Y, Tomita K, Saito H
    • Journal Title

      Clin Exp Nephrol

      Volume: 15(6) Pages: 820-830

    • NAID

      10030341588

    • Data Source
      KAKENHI-PROJECT-21390048
  • [Journal Article] The relationship between treatment time of gemicitabine and development of hematologic toxicity in cancer patients2011

    • Author(s)
      Iwata K, Aizawa K, Sakai S, Jingami S, Fukunaga E, Yoshida M, Hamada A, Saito H
    • Journal Title

      Biol Pharm Bull

      Volume: 34 Pages: 1765-1768

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590167
  • [Journal Article] Prospective evaluation of pharmacokinetically guided dosing of carboplatin in Japanese patients with cancer2010

    • Author(s)
      Shimokata T, Ando Y, Yasuda Y, Hamada A, Kawada K, Saito H, Matsuo S, Kondo M, Imaizumi K, Hasegawa Y
    • Journal Title

      Cancer Sci

      Volume: 101 Pages: 2601-2605

    • NAID

      10027834680

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590167
  • [Journal Article] Contribution of BCR-ABL-independent Activation of ERK1/2 to Acquired Imatinib Resistance in K562Chronic Myeloid Leukemia Cells2010

    • Author(s)
      Nambu T, Araki N, Nakagawa A, Kuniyasu A, Kawaguchi T, Hamada A, Saito H
    • Journal Title

      Cancer Sci

      Volume: 10 Pages: 137-142

    • NAID

      10027199844

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590167
  • [Journal Article] Pathophysiological regulation of renal SLC22A organic ion transporters in acute kidney injury : pharmacological and toxicological implications2010

    • Author(s)
      Saito H
    • Journal Title

      Pharmacol Ther

      Volume: 125(1) Pages: 79-91

    • NAID

      120006540420

    • URL

      http://hdl.handle.net/2298/13109

    • Data Source
      KAKENHI-PROJECT-21390048
  • [Journal Article] Co-administration of irinotecan decreases the plasma concentration of an active metabolite of amrubicin, amrubicinol in rats2010

    • Author(s)
      Maeda Y, Hamada A, Sanematsu E, Sasaki JI, Yokoo K, Hira A, Saito H
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 65(5) Pages: 953-959

    • NAID

      120002469644

    • Data Source
      KAKENHI-PROJECT-21390048
  • [Journal Article] Pathophysiological regulation of renal SLC22A organic ion transporters in acute kidney injury : pharmacological and toxicological implications2010

    • Author(s)
      Saito H
    • Journal Title

      Pharmacology and Therapeutics 125

      Pages: 79-91

    • NAID

      120006540420

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390048
  • [Journal Article] Contribution of BCR-ABL-independent activation of ERK1/2 to acquired imatinib resistance in K562 chronic myeloid leukemia cells2010

    • Author(s)
      Nambu T, Araki N, Nakagawa A, Kuniyasu A, Kawaguchi T, Hamada A, Saito H
    • Journal Title

      Cancer Sci

      Volume: 101(1) Pages: 137-142

    • NAID

      10027199844

    • Data Source
      KAKENHI-PROJECT-21390048
  • [Journal Article] P-Glycoprotein mediates efflux transport of darunavir in human intestinal Caco-2 and ABCB1 gene-transfected renal LLC-PK1 cell lines2009

    • Author(s)
      Fujimoto H, Higuchi M, Watanabe H, Koh Y, Ghosh AK, Mitsuya H, Tanoue N, Hamada A, Saito H
    • Journal Title

      Biol Pharm Bull

      Volume: 32 Pages: 1588-1593

    • NAID

      130000117288

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590167
  • [Journal Article] Effects of oral administration of S-1 on the pharmacokinetics of SN-38, irinotecan active metabolite, in patients with advanced colorectal cancer2009

    • Author(s)
      Yokoo K, Hamada A, Tazoe K, Sasaki Y, Saito H.
    • Journal Title

      Ther Drug Monit (in press)

    • NAID

      120002469601

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390158
  • [Journal Article] Relationship between an effective dose of imatinib2009

    • Author(s)
      Kawaguchi T, Hamada A, Hirayama C, Nakashima R, Nambu T, Yamakawa Y, Watanabe H, Horikawa H, Mitsuya H, Saito H
    • Journal Title

      body surface area, and trough drug levels in patients with chronic myeloid leukemia (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590149
  • [Journal Article] Acute and chronic metabolic acidosis interferes with aquaporin-2 translocation in the rat kidney collecting ducts2009

    • Author(s)
      Mouri T, Inoue T, Nonoguchi H, Nakayama Y, Miyazaki H, Matsuzaki T, Saito H, Nakanishi T, Kohda Y, Tomita K
    • Journal Title

      Hypertens Res

      Volume: 32(5) Pages: 358-363

    • NAID

      10026122512

    • Data Source
      KAKENHI-PROJECT-21390048
  • [Journal Article] P-Glycoprotein mediates efflux transport of darunavir in human intestinal Caco-2 and ABCB1 gene-transfected renal LLC-PK1 cell lines2009

    • Author(s)
      Fujimoto H, Hicuchi M, Watanabe H, Koh Y, Ghosh AK, Mitsuya H, Tanoue N, Hamada A, Saito H
    • Journal Title

      Biol Pharm Bull

      Volume: 32(9) Pages: 1588-1593

    • NAID

      130000117288

    • Data Source
      KAKENHI-PROJECT-21390048
  • [Journal Article] Enhanced renal accumulation of cisplatin via renal organic cation transporter deteriorates acute kidney injury in hypomagnesemic rats2009

    • Author(s)
      Yokoo K, Murakami R, Matsuzaki T, Yoshitome K, Hamada A, Saito H
    • Journal Title

      Clin Exp Nephrol

      Volume: 13(6) Pages: 578-584

    • NAID

      10027227458

    • URL

      http://hdl.handle.net/2298/15589

    • Data Source
      KAKENHI-PROJECT-21390048
  • [Journal Article] Relationship between an effective dose of imatinib, body surface area, and trough drug levels in patients with chronic myeloid leukemia2009

    • Author(s)
      K awaguchi T, Hamada A, Hirayama C, Nakashima R, Nambu T, Yamakawa Y, Watanabe H, Horikawa H, Mitsuya H, Saito H
    • Journal Title

      Int J Hematol

      Volume: 89 Pages: 642-8

    • NAID

      10025161955

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590167
  • [Journal Article] Constitutive overexpression of P-glycoprotein, rather than breast cancer resistance protein or organic cation transporter 1, contributes to acquisition of imatinib-resistance in K562 cells2009

    • Author(s)
      Hirayama C, Watanabe H, Nakashima R, Nanbu T, Hamada A, Kuniyasu A, Nakayama H, Kawaguchi T, Saito H.
    • Journal Title

      Pharm Res. 25

      Pages: 827-835

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390158
  • [Journal Article] Co-administration of irinotecan decreases the plasma concentration of an active metabolite of amrubicin, amrubicinol in rats2009

    • Author(s)
      Maeda Y, Hamada A, Sanematsu E, Sasaki J, Yokoo K, Hira A, Saito H
    • Journal Title

      Can cer Chemother Pharmacol

      Volume: 65 Pages: 653-659

    • NAID

      120002469644

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590167
  • [Journal Article] Effects of oral administered S-1 on the pharmacokinetics of SN-38, irinotecan active metabolite, in patients with advanced colorectal cancer.2009

    • Author(s)
      Yokoo K, Hamada A, Tazoe K, Sasaki Y, Saito H
    • Journal Title

      Ther Drug Monit (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590149
  • [Journal Article] Role of P-glycoprotein in accumulation and cytotoxicity of amrubicin and amrubicinol in MDR1 gene-transfected LLC-PK1 cells and human A549 lung adenocarcinoma cells2008

    • Author(s)
      Hira A, Watanabe H, Maeda Y, Yokoo K, Sanematsu E, Fujii J, Sasaki JI, Hamada A, Saito H.
    • Journal Title

      Biochem Pharmacol 75

      Pages: 973-980

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390158
  • [Journal Article] Altered pharmacokinetics of cationic drugs caused by down-regulation of renal rOCT2 (Slc22a2)and rMATE1 (Slc47a1)in ischemia/reperfusioninduced acute kidney injury2008

    • Author(s)
      Matsuzaki T, Morisaki T, Sugimoto W, Yokoo K, Sato D, Nonoguchi H, Tomita K, Terada T, Inui K, Hamada A, Saito H.
    • Journal Title

      Drug Metab Dispos 36

      Pages: 649-654

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390158
  • [Journal Article] Constitutive overexpression of P-glycoprotein, rather than breast cancer resistance protein or organic cation transporter 1, contributes to acquisition of imatinib-resistance in K562 cells2008

    • Author(s)
      Hirayama C, Watanabe H, Nakashima R, Nanbu T, Hamada A, Kuniyasu A, Nakayama H, Kawaguchi T, Saito H
    • Journal Title

      Pharm Res 25

      Pages: 827-835

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590149
  • [Journal Article] Role of P-glycoprotein in accumulation and cytotoxicity of amrubicin and amrubicinol in MDR1 gene-transfected LLC-PK1 cells and human A549 lung adenocarcinoma cells2008

    • Author(s)
      Hira A, Watanabe H, Maeda Y, Yokoo K, Sanematsu E, Fujii J, Sasaki J, Hamada A, Saito H
    • Journal Title

      Biochem Pharmacol 75

      Pages: 973-980

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590149
  • [Journal Article] Regulation of renal organic ion transporters in cisplatin-induced acute kidney injury and uremia in rats2008

    • Author(s)
      Morisaki T, Matsuzaki T, Yokoo K, Kusumoto M, Iwata K, Hamada A, Saito H
    • Journal Title

      Pharm Res. 25

      Pages: 2526-2533

    • NAID

      120002469602

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390158
  • [Journal Article] Downregulation of organic anion transporters in rat kidney under ischemia/reperfusion-induced acute renal failure2007

    • Author(s)
      Matsuzaki T, Watanabe H, Yoshitome K, Morisaki T, Hamada A, Nonoguchi H, Kohda Y, Tomita K, Inui K, Saito H
    • Journal Title

      Kidney Int. 71

      Pages: 539-547

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390158
  • [Journal Article] Involvement of indoxyl sulfate in renal and central nervous system toxicities during cisplatin-induced acute renal failure2007

    • Author(s)
      Iwata K, Matsuzaki T, Watanabe H, Morisaki T, Ohmura T, Hamada A, SaitoH.
    • Journal Title

      Pharm Res. 24

      Pages: 662-671

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390158
  • [Journal Article] Downregulation of organic anion transporters in rat kidney under ischemialreperfusion-induced acute renal failure.2007

    • Author(s)
      Matsuzaki T, Watanabe H, Yoshitome K, Morisaki T, Hamada A, Nonoguchi H, Kohda Y, Tomita K, Inui K, Saito H.
    • Journal Title

      Kidney Int. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590131
  • [Journal Article] Involvement of Indoxyl Sulfate in Renal and Central Nervous System Toxicities During Cisplatin-Induced Acute Renal Failure.2007

    • Author(s)
      Iwata K, Watanabe H, Morisaki T, Matsuzaki Ohmura T, Hamada A, Saito H.
    • Journal Title

      Pharm Res. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590131
  • [Journal Article] Pharmacokinetics of amrubicin and its active metabolite amrubicinol in lung cancer patients.2006

    • Author(s)
      Matsunaga Y, Hamada A, Okamoto I, Sasaki J, Moriyama E, Kishi H, Matsumoto M, Hira A, Watanabe H, Saito H.
    • Journal Title

      Ther Drug Monit. 28(1)

      Pages: 76-82

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590131
  • [Journal Article] Phase I and pharmacokinetic study of amrubicin, a synthetic 9-aminoanthracycline, in patients with refractory or relapsed lung cancer.2006

    • Author(s)
      Okamoto I, Hamada A, Matsunaga Y, Sasaki J, Fujii S, Uramoto H, Yamagata H, Mori I, Kishi H, Semba H, Saito H.
    • Journal Title

      Cancer Chemother Pharmacol. 57(3)

      Pages: 282-288

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590131
  • [Journal Article] Effect of S-1 on pharmacokinetics of irinotecan in a patient with colorectal cancer.2006

    • Author(s)
      Yokoo K, Watanabe H, Hamada A, Masa K, Saito H, Terazaki H, Sasaki Y.
    • Journal Title

      Clin Pharmacol Ther. 80(4)

      Pages: 422-424

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590131
  • [Journal Article] Daily expression of clock genes in whole blood cells in healthy subjects and a patient with circadian rhythm sleep disorder.2005

    • Author(s)
      Takimoto M, Hamada A, Tomoda A, Ohdo S, Ohmura T, Sakato H, Kawatani J, Jodoi T, Nakagawa H, Terazono H, Koyanagi S, Higuchi S, Kimura M, Tukikawa H, Irie S, Saito H, Miike T.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol. 289(5)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590131
  • [Journal Article] Pharmacokinetic changes of irinotecan by intestinal alkalinization in an advanced colorectal cancer patient.2005

    • Author(s)
      Hamada A, Aoki A, Terazaki H, Ito K, Yokoo K, Sasaki Y, Saito H.
    • Journal Title

      Ther Drug Monit. 27(4)

      Pages: 536-538

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590131
  • [Patent] インドキシル硫酸の産生の阻害剤のスクリーニング方法、インドキシル硫酸代謝産生阻害剤、及び腎障害軽減剤2010

    • Inventor(s)
      齋藤秀之、濱田哲暢
    • Industrial Property Rights Holder
      国立大学法人熊本大学
    • Industrial Property Number
      2010-234185
    • Filing Date
      2010-10-19
    • Data Source
      KAKENHI-PROJECT-21390048
  • [Patent] インドキシル硫酸の産生の阻害剤のスクリーニング方法、インドキシル硫酸代謝産生阻害剤、及び腎障害軽減剤2010

    • Inventor(s)
      齋藤秀之, 濱田哲暢
    • Industrial Property Rights Holder
      熊本大学
    • Industrial Property Number
      2010-234185
    • Filing Date
      2010-10-19
    • Data Source
      KAKENHI-PROJECT-21390048
  • [Patent] エルロチニブの副作用又は薬効を判定する方法2009

    • Inventor(s)
      濱田哲暢、佐々木治一郎、齋藤秀之、興梠博次
    • Industrial Property Rights Holder
      国立大学法人熊本大学
    • Industrial Property Number
      2009-116385
    • Filing Date
      2009-05-13
    • Data Source
      KAKENHI-PROJECT-19590149
  • [Patent] インドキシル硫酸の産生の阻害剤のスクリーニング方法2009

    • Inventor(s)
      齋藤秀之, 濱田哲暢
    • Industrial Property Rights Holder
      熊本大学
    • Industrial Property Number
      2009-240062
    • Filing Date
      2009-10-19
    • Data Source
      KAKENHI-PROJECT-21390048
  • [Patent] エルロチニブの副作用又は薬効を判定する方法2009

    • Inventor(s)
      濱田哲暢、佐々木治一郎、齋藤秀之、興梠博次
    • Industrial Property Rights Holder
      国立大学法人熊本大学
    • Industrial Property Number
      2009-116385
    • Filing Date
      2009-05-31
    • Data Source
      KAKENHI-PROJECT-21590167
  • [Presentation] Unilateral ureteral obstruction (UUO)-induced renal fibrosis is attenuated by suppression of indoxyl sulfate (IS) accumulation in sulfotransferase (Sult)1a1-deficient mice2023

    • Author(s)
      HOU Huixian, Horikawa Mai, Narita Yuki, Jono Hirofumi, Saito Hideyuki
    • Organizer
      第66回日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K24047
  • [Presentation] 糖尿病モデルラットを用いた造影剤腎症の発症機序解明に基づく予防策の基盤検証2023

    • Author(s)
      大井桃、成田勇樹、黒木香吉、城野博史、齋藤秀之
    • Organizer
      第66回日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K24047
  • [Presentation] Inhibition of indoxyl sulfate production and accumulation prevents renal fibrosis in sulfotransferase (Sult)1a1-deficient mice2023

    • Author(s)
      Hou H, Horikawa M, Narita Y, Jono H, Saito H.
    • Organizer
      第6回日本Uremic Toxin研究会学術集会
    • Data Source
      KAKENHI-PROJECT-23K24047
  • [Presentation] Novel roles of ribosomal protein S6 promotes development and maintenance of glioblastoma multiforme stem cells2022

    • Author(s)
      Hirofumi Jono, Yuki Shirakawa, Yuki Ito, Shunsuke Miyake, Ayumi Kanemaru, Takuichiro Hide, Akitake Mukasa, Kunimasa Ohta, Hideyuki Saito
    • Organizer
      第95回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] 血清トラフ濃度25μg/mLを目標としたテイコプラニン維持投与量に関する後方視的検討2022

    • Author(s)
      近藤 昭志, 尾田 一貴, 片野田 朋美, 成田 勇樹, 岩村 耕次, 野坂 生郷, 城野 博史, 齋藤 秀之
    • Organizer
      日本TDM学会
    • Data Source
      KAKENHI-PROJECT-23K24047
  • [Presentation] 硫酸転移酵素Sult1a1欠損マウスを用いた慢性腎臓病の心血管疾患発症に対するインドキシル硫酸の寄与解明2022

    • Author(s)
      西垣 愛奈, 成田 勇樹, 有馬 勇一郎, 辻田 賢一, 城野 博史, 齋藤 秀之
    • Organizer
      日本腎臓学会
    • Data Source
      KAKENHI-PROJECT-23K24047
  • [Presentation] シスプラチン誘発急性腎障害におけるインドキシル硫酸の毒性学的役割の解明2022

    • Author(s)
      堀川 真衣, 薮内 希実, 成田 勇樹, 城野 博史, 齋藤 秀之
    • Organizer
      日本腎臓学会
    • Data Source
      KAKENHI-PROJECT-23K24047
  • [Presentation] ダプトマイシン低感受性化およびリネゾリド耐性化に至ったMRSAによる感染性大動脈瘤感染症難治例の1例2022

    • Author(s)
      尾田 一貴, 片野田 朋美, 岡本 真一郎, 中田 浩智, 齋藤 秀之
    • Organizer
      日本化学療法学会
    • Data Source
      KAKENHI-PROJECT-23K24047
  • [Presentation] CKD及び糖尿病モデルラットを用いた造影剤誘発急性腎障害の発症リスクおよび生理食塩水の予防効果の検証2022

    • Author(s)
      黒木 香吉, 田中 仁美, 成田 勇樹, 城野 博史, 齋藤 秀之
    • Organizer
      日本腎臓学会
    • Data Source
      KAKENHI-PROJECT-23K24047
  • [Presentation] 真珠腫組織におけるCYLD 発現に着目した臨床病理学的解析2021

    • Author(s)
      三宅俊介、三輪徹、米田剛、金丸歩美、齋藤陽元、蓑田涼生、折田頼尚、齋藤秀之、城野博史
    • Organizer
      第61回日本臨床化学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] CYLD 発現低下による予後不良トリプルネガティブ型乳癌に対するNF-kB シグナル標的治療の有効性2021

    • Author(s)
      新垣ひとみ、桑野明香里、平井ちか、末永尚輝、金丸歩美、三宅俊介、林光博、成田勇樹、齋藤秀之、城野博史
    • Organizer
      第61回日本臨床化学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] 進行卵巣癌における腫瘍抑制遺伝子CYLD 発現低下の臨床的意義の解明2021

    • Author(s)
      松山果穂、三宅俊介、下村祐美、金丸歩美、西郷智香、成田勇樹、本岡大社、岩越裕、本原剛志、 片渕秀隆、齋藤秀之、城野博史
    • Organizer
      第61回日本臨床化学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] リン酸化プロテオミクスを活用したCYLD発現低下・予後不良膠芽腫に対する新規治療標的の探索2021

    • Author(s)
      伊藤由貴、山岡道子、白川裕貴、増田豪、秀拓一郎、成田勇樹、齋藤秀之、城野博史
    • Organizer
      第74回薬理学会西南部会
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] Novel roles of tumor suppressor CYLD in malignant characteristics of glioblastoma multiforme2021

    • Author(s)
      Hirofumi Jono, Yuki Ito, Michiko Yamaoka, Yuki Shirakawa, Takuichiro Hide, Hideyuki Saito
    • Organizer
      The 23rd Korea-Japan Joint Seminar on Pharmacology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] 卵巣癌における腫瘍抑制遺伝子 CYLD 発現低下の臨床的・生物学的意義の解明2021

    • Author(s)
      三宅俊介、松山果穂、下村祐美、金丸歩美、西郷智香、本岡大社、岩越裕、本原剛志、片渕秀隆、齋藤秀之
    • Organizer
      第38回日本薬学会九州山口支部大会
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] Biological significance of CYLD expression in malignant characteristics of glioblastoma multiforme2021

    • Author(s)
      伊藤由貴、山岡道子、白川裕貴、秀拓一郎、齋藤秀之、城野博史
    • Organizer
      第94回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] 卵巣癌における腫瘍抑制遺伝子CYLD発現消失の臨床薬理学的意義の解明2021

    • Author(s)
      三宅俊介、齋藤秀之、城野博史
    • Organizer
      第42回日本臨床薬理学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] Biological significance of CYLD downregulation in Triple negative breast cancer.2021

    • Author(s)
      桑野明香里、平井ちか、末永尚輝、金丸歩美、新垣ひとみ、林光博、西郷智香、齋藤秀之、城野博史
    • Organizer
      第94回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] 硫酸抱合型尿毒素の産生責任酵素SULT1A1を標的とした腎障害進展抑制治療薬の探索2020

    • Author(s)
      齋藤秀之
    • Organizer
      第30回日本医療薬学会年会
    • Data Source
      KAKENHI-PROJECT-17H04104
  • [Presentation] 非小細胞肺癌における腫瘍抑制遺伝子CYLD発現の予後・効果予測因子としての可能性の検証2020

    • Author(s)
      西村 優佳,髙野 佳奈子,末永 尚輝,三宅 俊介,金丸 歩美,齋藤 秀之,城野 博史
    • Organizer
      第73回薬理学会西南部会
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] UNILATERAL URETER OBSTRUCTION (UUO)-INDUCED RENAL FIBROSIS IS ATTENUATED BY SUPPRESSION OF INDOXYL SULFATE (IS) ACCUMULATION IN SULFOTRANSFERASE (SULT)1A1-DEFICIENT MICE2020

    • Author(s)
      Huixian Hou, Nozomi Yabuuchi, Nao Gunda, Rika Fujino, Yuya Hayashi, Yuki Narita, Hirofumi Jono, Hideyuki Saito
    • Organizer
      ・The 57th European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Fully Virtual Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04104
  • [Presentation] 口腔腔扁平上皮癌細胞の抗がん剤性感受性に対するがん抑制遺伝子CYLD発現低下の影響2019

    • Author(s)
      小関利弥、末永尚輝、金丸歩美、髙野佳奈子、西村優佳、齋藤秀之、城野博史
    • Organizer
      第36回日本薬学会九州支部大会
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] Sulfotransferase (Sult) 1a1 plays a toxico- pathological role in cisplatin-induced acute kidney injury (AKI) through metabolic generation of indoxyl sulfate (IS)2019

    • Author(s)
      Hou K, Fujino R, Unoki S; Tanaka H; Matsushita K, Gunda N, Jono H, Saito H
    • Organizer
      World Congress of Nephrology 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04104
  • [Presentation] 口腔扁平上皮癌におけるがん抑制遺伝子CYLDの治療効果予測マーカーとしての有用性の検証2019

    • Author(s)
      小関利弥、末永尚輝、金丸歩美、高野佳奈子、西村優佳、齋藤秀之、城野博史
    • Organizer
      医療薬学フォーラム2019 第27回クリニカルファーマシーシンポジウム
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] 口腔癌におけるCYLD発現低下誘導性のシスプラチン耐性化機序の解明2019

    • Author(s)
      末永尚輝、金丸歩美、小関利弥、齋藤秀之、城野博史
    • Organizer
      医療薬学フォーラム2019 第27回クリニカルファーマシーシンポジウム
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] Establishing individualized medicine for intractable cancer based on clinical molecular pathogenesis - A novel predictive marker CYLD for molecular targeted therapies -2019

    • Author(s)
      Jono H, Saito H
    • Organizer
      第92回日本薬理学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] 口腔癌における腫瘍抑制遺伝子 CYLD 発現の効果予測マーカーとしての有用性2019

    • Author(s)
      城野博史、高野佳奈子、西村優佳、末永尚輝、金丸歩美、三宅俊介、小関利弥、齋藤秀之
    • Organizer
      日本臨床腫瘍薬学会学術大会2019
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] 膠芽腫の薬物治療抵抗性におけるがん抑制遺伝子CYLD発現の意義2019

    • Author(s)
      山岡道子、白川裕貴、伊藤由貴、秀拓一郎、齋藤秀之、城野博史
    • Organizer
      医療薬学フォーラム2019 第27回クリニカルファーマシーシンポジウム
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] 糖尿病(DM)併発虚血性急性腎障害(AKI)ラットの病態進展におけるインドキシル硫酸(IS)の関与2019

    • Author(s)
      鵜木隼平、小山直子、下河優奈、城野博史、齋藤秀之
    • Organizer
      第62回日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-17H04104
  • [Presentation] 血液透析患者における心血管合併症および予後予測因子としてのインドキシル硫酸の有用性検証2019

    • Author(s)
      松下馨介、米田剛、中田悦史、西一彦、城野博史、齋藤秀之
    • Organizer
      第62回日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-17H04104
  • [Presentation] Ischemia-Reperfusion-Induced AKI (IR-AKI) Associated with Renal Fibrosis Is Attenuated Through Suppressing Indoxyl Sulfate Accumulation in Sulfotransferase (Sult) 1a1-Deficient Mice2019

    • Author(s)
      Matsushita K, Gunda N, Fujino R, Nishigaki A, Hayashi Y, Nishi K, Jono H, Saito H
    • Organizer
      Kidney Week 2019, American Society of Nephrology Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04104
  • [Presentation] Loss of tumor suppressor CYLD expression induces cisplatin resistance in oral squamous cell carcinoma2019

    • Author(s)
      Suenaga N, Kanemaru A, Ozeki K, Saito H, Jono H
    • Organizer
      第29回日本医療薬学会年会(International symposium)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] Clinical significance of CYLD down-regulation in invasiveness of triple negative breast cancer2019

    • Author(s)
      Kuwano A, Hirai C, Suenaga N, Kanemaru A, Hayashi M, Saito H, Jono H
    • Organizer
      第29回日本医療薬学会年会(International symposium)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] 卵巣癌における腫瘍抑制遺伝子CYLDの発現消失はAktシグナルを介した悪性化形質獲得の要因となる2019

    • Author(s)
      三宅俊介、金丸歩美、高野佳奈子、西郷智香、本岡大社、本原剛志、齋藤秀之、城野博史
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] トリプルネガティブ型乳癌の悪性化形質獲得における腫瘍抑制遺伝子CYLD発現低下の臨床的意義2019

    • Author(s)
      桑野明香里、平井ちか、末永尚輝、金丸歩美、三宅俊介、林光博、齋藤秀之、城野博史
    • Organizer
      第59回日本臨床化学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] Unilateral Ureter Obstruction (UUO)-Induced Renal Fibrosis Is Attenuated by Suppression of Indoxyl Sulfate (IS) Accumulation in Sulfotransferase (Sult)1a1-Deficient Mice2019

    • Author(s)
      Huixian H, Fujino R, Hayashi Y, Unoki J, Matsushita K, Gunda N, Jono H, Saito H
    • Organizer
      Kidney Week 2019, American Society of Nephrology Annual Meeting
    • Data Source
      KAKENHI-PROJECT-17H04104
  • [Presentation] 乳癌薬物療法における腫瘍抑制遺伝子 CYLD 発現低下の臨床的意義の解明2018

    • Author(s)
      西郷智香、平井ちか、桑野明香里、林光博、岩瀬弘敬、齋藤秀之、城野博史
    • Organizer
      第28回日本医療薬学会年会
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] 乳癌薬物療法に対する耐性獲得における生命予後規定因子 CYLD 発現低下の臨床的意義の解明2018

    • Author(s)
      城野博史、平井ちか、西郷智香、林光博、神力悟、安東由喜雄、齋藤秀之、岩瀬弘敬
    • Organizer
      医療薬学フォーラム2018 第26回クリニカルファーマシーシンポジウム
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] 進行卵巣癌における CYLD 発現変動の臨床的意義の解明および分子診断・個別化治療への応用可能性の検討2018

    • Author(s)
      三宅俊介、金丸歩美、髙野佳奈子、西郷智香、本岡大社、本原剛志、齋藤秀之、城野博史
    • Organizer
      日本臨床化学会第58回年次学術集会
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] Loss of CYLD expression correlates with deep tumor invasion & poor prognosis in patients with invasive oral squamous cell carcinoma2018

    • Author(s)
      Jono H, Shinriki S, Suenaga N, Kanemaru A, Miyake S, Takano K, Yoshida S, Saito H
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology (WCP2018)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] 腫瘍悪性化形質における腫瘍抑制遺伝子 CYLD 発現低下の生物学的意義の解明2018

    • Author(s)
      髙野佳奈子、西村優佳、末永尚輝、金丸歩美、三宅俊介、小関利弥、齋藤秀之、城野博史
    • Organizer
      第35回日本薬学会九州支部大会
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] 乳癌薬物療法における腫瘍抑制遺伝子 CYLD 発現低下の臨床的意義の解明2018

    • Author(s)
      城野博史、平井ちか、西郷智香、林光博、神力悟、安東由喜雄、岩瀬弘敬、齋藤秀之
    • Organizer
      日本臨床化学会第58回年次学術集会
    • Data Source
      KAKENHI-PROJECT-18H02591
  • [Presentation] Elucidation of mechanism for indoxyl sulfate (IS)-promoted renal fibrotic response in HK-2 cells under hypoxic condition and mice with ischemia-reperfusion (IR)-induced AKI2017

    • Author(s)
      Yamashita M, Eto M, Yoneda G, Fujino R, Jono H, Saito H
    • Organizer
      ・Kidney Week 2017, American Society of Nephrology Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04104
  • [Presentation] Experimental confirmation of toxico-pharmacological role of sulfate-conjugated uremic solutes in cisplatin nephropathy2017

    • Author(s)
      Fujino R, Unoki S, Tanaka H, Matsushita K, Yoneda G, Miyake S, Jono H, Saito H
    • Organizer
      ・Kidney Week 2017, American Society of Nephrology Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04104
  • [Presentation] 低酸素条件下におけるインドキシル硫酸の腎線維化亢進作用メカニズムの解明2017

    • Author(s)
      山下真美、衛藤萌、米田剛、藤野梨香、城野博史、齋藤秀之
    • Organizer
      第60回日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-17H04104
  • [Presentation] 分子病理学的解析に基づいたアデニン誘発性慢性腎臓病モデル動物の有用性検証2017

    • Author(s)
      飯田優美、阿部絵理佳、藤野梨香、城野博史、齋藤秀之
    • Organizer
      第60回日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-17H04104
  • [Presentation] STZ 誘発糖尿病モデルラットにおける虚血性急性腎障害の病態進展因子の探索2016

    • Author(s)
      小山直子、下河優奈、桒原孝成、向山政志、城野博史、齋藤秀之
    • Organizer
      第59回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-17
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Presentation] CKD 病態進展における腫瘍抑制遺伝子CYLD発現消失の臨床的意義2016

    • Author(s)
      城野博史、三宅俊介、米田剛、末永尚輝、薮内希実、西一彦、 齋藤秀之
    • Organizer
      第26回日本医療薬学会年会
    • Place of Presentation
      京都
    • Year and Date
      2016-09-17
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Presentation] Pathological and molecular characteristics of adenine-induced chronic kidney disease (CKD) model in rats.2016

    • Author(s)
      Abe E, Xiao L, Iida Y, Oyama N, Jono H, Saito H
    • Organizer
      Kidney Week 2016, American Society of Nephrology Annual Meeting
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2016-11-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Presentation] 敗血症性AKIに対するShikoninの腎機能保護効果機構の解明2016

    • Author(s)
      川良まどか、松永里香、山本悠子、城野博史、齋藤秀之
    • Organizer
      第59回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-17
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Presentation] Shikonin Elicits A Nephropreventive Effect In A Murine Model of LPS-Induced Septic AKI by Triggering Nrf2 Activation With Anti-Oxidative Responses.2016

    • Author(s)
      Yoneda G, Kawara M, Yamamoto Y, Matsunaga R, Jono H, Saito H
    • Organizer
      Kidney Week 2016, American Society of Nephrology Annual Meeting
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2016-11-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Presentation] 硫酸転移酵素(SULT)を標的とした従来にない腎保護・治療薬の開発2015

    • Author(s)
      山下真実、西郷智香、野村結衣、佐潟雅隆、米田剛、西一彦、城野博史、齋藤秀之
    • Organizer
      第55回日本臨床化学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-30
    • Data Source
      KAKENHI-PROJECT-25670080
  • [Presentation] Involvement of indoxyl sulfate in exacerbated susceptibility of streptozotocin (STZ)-induced2015

    • Author(s)
      Shimokawa Y, Oyama N, Kuwabara T, Mukoyama M, Jono H, Saito H
    • Organizer
      2015 American Society of Nephrology Annual Meeting
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2015-11-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25670080
  • [Presentation] CKD 病態進展における慢性炎症制御因子CYLD の病態生理学的意義2015

    • Author(s)
      米田剛、末永尚輝、薮内希実、西一彦、城野博史、齋藤秀之
    • Organizer
      第58回日本腎臓学会学術総会
    • Place of Presentation
      名古屋 名古屋国際会議場
    • Year and Date
      2015-06-05
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Presentation] Methotrexate (MTX) induced kidney damage through intracellular mechanism2015

    • Author(s)
      Xiao L, Yamakawa Y, Abe E, Yamashita M, Iida Y, Jono H, and Saito H
    • Organizer
      International Symposium on Chronic Inflammatory Diseases, Kumamoto (ISCIDK2015)
    • Place of Presentation
      熊本 くまもと県民交流館パレア
    • Year and Date
      2015-10-16
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Presentation] Involvement of indoxyl sulfate in exacerbated susceptibility of streptozotocin (STZ)-induced2015

    • Author(s)
      Shimokawa Y, Oyama N, Kuwabara T, Mukoyama M, Jono H, Saito H
    • Organizer
      2015 American Society of Nephrology Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2015-11-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Presentation] 腎疾患・尿毒症における薬剤適正使用と治療薬探索の動向2015

    • Author(s)
      齋藤秀之
    • Organizer
      日本薬剤学会第30年会
    • Place of Presentation
      長崎 長崎ブリックホール
    • Year and Date
      2015-05-21
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Presentation] 急性腎障害に伴う急性肺障害発症メカニズムにおけるインドキシル硫酸の関与2015

    • Author(s)
      米田剛、薮内希実、佐潟雅隆、西郷智香、西一彦、城野博史、齋藤秀之
    • Organizer
      第55回日本臨床化学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-30
    • Data Source
      KAKENHI-PROJECT-25670080
  • [Presentation] Involvement of CYLD as a regulatory factor in fibrotic response of ischemic AKI kidney and hypoxic HK-2 cells2015

    • Author(s)
      Yoneda G, Suenaga N, Yabuuchi N, Nishi K, Jono H, Saito H
    • Organizer
      2015 American Society of Nephrology Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2015-11-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Presentation] Involvement of CYLD as a regulatory factor in fibrotic response of ischemic AKI kidney and hypoxic HK-2 cells2015

    • Author(s)
      Yoneda G, Suenaga N, Yabuuchi N, Nishi K, Jono H, Saito H
    • Organizer
      2015 American Society of Nephrology Annual Meeting
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2015-11-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25670080
  • [Presentation] 硫酸転移酵素(SULT)を標的とした新規腎保護・治療薬の開発2015

    • Author(s)
      西郷智香、野村祐衣、米田剛、山本悠子、城野博史、齋藤秀之
    • Organizer
      ・医療薬学フォーラム2015/第23回クリニカルファーマシーシンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2015-07-04
    • Invited
    • Data Source
      KAKENHI-PROJECT-25670080
  • [Presentation] 硫酸転移酵素(SULT)を標的とした新規腎保護・治療薬の開発2015

    • Author(s)
      西郷智香、野村祐衣、米田剛、山本悠子、城野博史、齋藤秀之
    • Organizer
      医療薬学フォーラム2015/第23回クリニカルファーマシーシンポジウム
    • Place of Presentation
      名古屋  名古屋国際会議場
    • Year and Date
      2015-07-04
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Presentation] 腎疾患・尿毒症における薬剤適正使用と治療薬探索の動向2015

    • Author(s)
      齋藤秀之
    • Organizer
      日本薬剤学会第30年会
    • Place of Presentation
      長崎
    • Year and Date
      2015-05-21
    • Invited
    • Data Source
      KAKENHI-PROJECT-25670080
  • [Presentation] CKD 病態進展における慢性炎症制御因子CYLD の病態生理学的意義2015

    • Author(s)
      米田剛、末永尚輝、薮内希実、西一彦、城野博史、齋藤秀之
    • Organizer
      第58回日本腎臓学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-06-05
    • Data Source
      KAKENHI-PROJECT-25670080
  • [Presentation] 虚血性急性腎障害ラットにおけるインドキシル硫酸産生阻害の腎保護効果2014

    • Author(s)
      小山直子、西郷智香、佐潟雅隆、野村結衣、松永里香、城野博史、西一彦、齋藤秀之
    • Organizer
      第67回日本薬理学会西南部会
    • Place of Presentation
      福岡
    • Year and Date
      2014-11-23
    • Data Source
      KAKENHI-PROJECT-25670080
  • [Presentation] 虚血性急性腎障害ラットにおけるインドキシル硫酸産生阻害の腎保護効果2014

    • Author(s)
      野村結衣、松永里香、城野博史、西一彦、齋藤秀之
    • Organizer
      第67回日本薬理学会西南部会
    • Place of Presentation
      福岡
    • Year and Date
      2014-11-23
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Presentation] Hepatic sulfotransferase (SULT) as a potential target for amelioration of ischemic acute kidney injury (AKI) by suppressing indoxyl sulfate accumulation2014

    • Author(s)
      Saito H, Saigo C, Yoshimura M, Komori M, Yamamoto Y, Nomura Y, Sagata M, Matsunaga R, Nishi K, Jono H
    • Organizer
      第8回国際尿毒症学会
    • Place of Presentation
      沖縄コンベンションセンター
    • Data Source
      KAKENHI-PROJECT-25670080
  • [Presentation] Involvement of Indoxyl sulfate (IS) in downregulation of pulmonary aquaporin (AQP)-5 in rats caused by bilateral nephrectomy (BNx)-induced acute kidney injury (AKI)2013

    • Author(s)
      Sagata M, Saigo C, Yoneda G, Yamamoto Y, Nomura Y, Nishi K, Jono H, Saito H.
    • Organizer
      アメリカ腎臓学会第46回年会
    • Place of Presentation
      ジョージア国際会議場(アトランタ)
    • Data Source
      KAKENHI-PROJECT-25670080
  • [Presentation] 虚血再灌流急性腎障害ラットにおけるインドキシル硫酸産生阻害薬物の腎保護効果2013

    • Author(s)
      西郷智香、佐潟雅隆、野村祐依、松永里香、西一彦、齋藤秀之
    • Organizer
      第34回日本臨床薬理学会学術総会
    • Place of Presentation
      東京国際フォーラム
    • Data Source
      KAKENHI-PROJECT-25670080
  • [Presentation] 虚血再灌流急性腎障害に伴うNrf2活性化にインドキシル硫酸蓄積が関与する2013

    • Author(s)
      佐潟雅隆、吉村美里、脇田紋佳、西郷智香、山本悠子、米田剛、中馬江里奈、野村祐衣、松下裕子、西一彦、城野博史、齋藤秀之
    • Organizer
      第56回日本腎臓学会学術総会
    • Place of Presentation
      東京国際フォーラム
    • Data Source
      KAKENHI-PROJECT-25670080
  • [Presentation] 両腎摘出急性腎障害モデルラットにおいてインドキシル硫酸が肺aquaporin-5の発現減少に関与する2013

    • Author(s)
      佐潟雅隆、西郷智香、山本悠子、米田剛、野村祐衣、西一彦、城野博史、齋藤秀之
    • Organizer
      第34回日本臨床薬理学会学術総会
    • Place of Presentation
      東京国際フォーラム
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Presentation] 虚血再灌流急性腎障害に伴うNrf2活性化にインドキシル硫酸蓄積が関与する2013

    • Author(s)
      佐潟雅隆、吉村美里、脇田紋佳、西郷智香、山本悠子、米田剛、中馬江里奈、野村祐衣、松下裕子、西一彦、城野博史、齋藤秀之
    • Organizer
      第56回日本腎臓学会学術総会
    • Place of Presentation
      東京国際フォーラム
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Presentation] 硫酸抱合型尿毒症物質の肝産生阻害を基軸とする腎保護・治療薬の探索2013

    • Author(s)
      齋藤秀之、佐潟雅隆、西郷智香、西一彦
    • Organizer
      BIOJAPAN2013/World Business Forum
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Presentation] 慢性腎臓病と薬剤の適正使用「腎障害における薬剤の適正使用」2013

    • Author(s)
      齋藤秀之
    • Organizer
      第23回日本医療薬学会年会
    • Place of Presentation
      仙台国際会議場
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Presentation] Involvement of Indoxyl sulfate (IS) in downregulation of pulmonary aquaporin (AQP)-5 in rats caused by bilateral nephrectomy (BNx)-induced acute kidney injury (AKI).2013

    • Author(s)
      Sagata M, Saigo C, Yoneda G, Yamamoto Y, Nomura Y, Nishi K, Jono H, Saito H.
    • Organizer
      アメリカ腎臓学会第46回年会
    • Place of Presentation
      アトランタ
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Presentation] 虚血再灌流急性腎障害ラットにおけるインドキシル硫酸産生阻害薬物の腎保護効果2013

    • Author(s)
      西郷智香、佐潟雅隆、野村祐依、松永里香、西一彦、齋藤秀之
    • Organizer
      第34回日本臨床薬理学会学術総会
    • Place of Presentation
      東京国際フォーラム
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Presentation] 腎機能低下に伴う経口分子標的治療薬の動態変動と影響因子2011

    • Author(s)
      齋藤秀之
    • Organizer
      医療薬学フォーラム2011旭川/クリニカルファーマシーシンポジウム
    • Place of Presentation
      旭川
    • Data Source
      KAKENHI-PROJECT-21390048
  • [Presentation] シンポジウム20・受容体・トランスポータ研究の最前線:抗悪性腫瘍薬の個別動態変動・毒性リスクとトランスポータ介在2011

    • Author(s)
      齋藤秀之
    • Organizer
      第32回日本臨床薬理学会年会
    • Place of Presentation
      浜松
    • Data Source
      KAKENHI-PROJECT-21390048
  • [Presentation] Alleviation of cisplatin-evoked acute kidney injury using phytochemical polyphenols is accompanied by reduced accumulation of indoxyl sulfate in rats2011

    • Author(s)
      Saito H., et al.
    • Organizer
      第7回国際尿毒症学会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-21390048
  • [Presentation] 薬剤性腎障害の推定発症機序と早期検出2010

    • Author(s)
      齋藤秀之
    • Organizer
      日本臨床薬理学会第31回年会
    • Place of Presentation
      国立京都国際会館(招待講演)
    • Year and Date
      2010-12-01
    • Data Source
      KAKENHI-PROJECT-21390048
  • [Presentation] 日本人におけるカルボプラチンの臨床薬理学的検討とカルバートの式の妥当性2009

    • Author(s)
      下方智也、安田宜成、河田健司、濱田哲暢、齋藤秀之、松尾清一、近藤征史、今泉和良、長谷川好規、安藤雄一
    • Organizer
      第7回日本臨床腫瘍学会学術集会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-19590149
  • [Presentation] 非小細胞肺癌患者におけるエルロチニブの薬物動態変動ならびに毒性との相関解析試験2009

    • Author(s)
      佐々木治一郎、濱田哲暢、岩本範博、稲葉恵、岸裕人、浦田真紀、牛島淳、佐伯祥、山下明寿、千場博、齋藤秀之、興梠博次
    • Organizer
      第7回日本臨床腫瘍学会学術集会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-19590149
  • [Presentation] 慢性骨髄性白血病治療薬イマチニブの血中濃度と至適投与量の関連2009

    • Author(s)
      濱田哲暢, 川口辰哉, 平山知恵, 中島麗子, 南部健, 山川裕司, 堀川健太郎, 齋藤秀之
    • Organizer
      第7回日本臨床腫瘍学会学術集会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-19590149
  • [Presentation] Distinct transport characteristics of platinum anticancer drugs, cisplatin and oxaliplatin, in renal tubular epithelial cell line LLC-PK_1 via organic cation transporter and copper transporter2009

    • Author(s)
      Saito H.
    • Organizer
      米国腎臓学会総会2009年会
    • Place of Presentation
      サンディエゴコンベンションセンター(米国)
    • Year and Date
      2009-10-30
    • Data Source
      KAKENHI-PROJECT-21390048
  • [Presentation] Therapeutic efficacy of imatinib at a reduced dose to relieve adverse effects was equivalent to the standard dose in chronic myeloid leukemia patients2008

    • Author(s)
      Hamada A, Kawaguchi T, Nakajima R, Hirayama C, Nanbu T, Watanabe H, Saito H
    • Organizer
      American Association for Cancer Research 99th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Data Source
      KAKENHI-PROJECT-19590149
  • [Presentation] K562細胞におけるBCR-ABL非依存的活性化ERKのimatinib抵抗性獲得への寄与2008

    • Author(s)
      南部健, 中川亜衣子, 川口辰哉, 荒木令江, 濱田哲暢, 齋藤秀之
    • Organizer
      第2回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-19590149
  • [Presentation] イマチニブ治療中の慢性骨髄性白血病患者における細胞内および血中薬物濃度の相関解析2008

    • Author(s)
      中島麗子, 南部健, 平山知絵, 濱田哲暢, 川口辰哉, 齋藤秀之
    • Organizer
      第29回日本臨床薬理学会年会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19590149
  • [Presentation]2008

    • Author(s)
      山川裕司, 中島麗子, 平山知絵, 濱田哲暢, 川口辰哉, 満屋裕明, 齋藤秀之
    • Organizer
      日本人における慢性骨髄性白血病治療薬イマチニブ(IM)の母集団薬物動態解析
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19590149
  • [Presentation] Characteristics of chronic-phase CML patients having durable cytogenetic response to low-dose imatinib2008

    • Author(s)
      Kawaguchi T, Hamada A, Nakashima R, Horikawa K, Ishihara S, Saito H, Hiroaki Mitsuya
    • Organizer
      American Society of Hematology 50th Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Data Source
      KAKENHI-PROJECT-19590149
  • [Presentation] Indoxyl sulfate is involved in the down-regulation of renal organic anion transporter OAT3 under ischemia/reperfusion-induced acute kidney injury2008

    • Author(s)
      Saito H. et.al.
    • Organizer
      The 41^<st> Annual Meeting of American Society of Nephrology
    • Place of Presentation
      フィラデルフィア
    • Year and Date
      2008-11-07
    • Data Source
      KAKENHI-PROJECT-17390158
  • [Presentation] Regulation of renal organic anion transporters in cisplatin-induced acute kidney injury and uremia in rats.2008

    • Author(s)
      Saito H.
    • Organizer
      米国腎臓学会総会2008年会
    • Place of Presentation
      ペンシルバニアコンベンションセンター
    • Year and Date
      2008-11-06
    • Data Source
      KAKENHI-PROJECT-17390158
  • [Presentation] S-1投与によるラット肝breast cancer resistance protein (Bcrp)の発現亢進と塩酸イリノテカン(CPT-11)体内動態変動2007

    • Author(s)
      横尾浩司, 濱田哲暢, 渡邊博志, 今井智之, 藤本裕美, 佐々木裕, 齋藤秀之
    • Organizer
      第29回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-19590149
  • [Presentation] 塩酸アムルビシンと塩酸イリノテカン併用における薬物動態学的検討2007

    • Author(s)
      前田友紀子, 實松絵美子, 濱田哲暢, 齋藤秀之
    • Organizer
      第28回日本臨床薬理学会年会
    • Place of Presentation
      宇都宮
    • Data Source
      KAKENHI-PROJECT-19590149
  • [Presentation] Down-regulation of rat organic ion transporter (Slc22A) family members by ischemia/reperfusion-induced acute renal failure2007

    • Author(s)
      齋藤 秀之
    • Organizer
      米国腎臓学会2007年会
    • Place of Presentation
      Moscone Center (San Francisco、CA)
    • Year and Date
      2007-11-04
    • Data Source
      KAKENHI-PROJECT-17390158
  • [Presentation] イマチニブ(IM)抵抗性白血病細胞株K562-IMにおけるABCトランスポータ及び有機カチオントランスポータの発現・機能解析に基づくIM耐性獲得機序の解明2007

    • Author(s)
      南部健, 平山知絵, 渡邊博志, 中島麗子, 濱田哲暢, 國安明彦, 中山仁, 川口辰哉, 齋藤秀之
    • Organizer
      第29回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-19590149
  • [Presentation] Down-regulation of organic ion transporter (Slc22A)family members by ischemia/ reperfusion-induced acute renal failure2007

    • Author(s)
      Saito H. et.al.
    • Organizer
      The 40^<th> Annual Meeting of American Society of Nephrology
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2007-11-01
    • Data Source
      KAKENHI-PROJECT-17390158
  • [Presentation] 肝硫酸転移酵素SULTを標的とするインドキシル硫酸産生阻害薬の腎保護作用と機序解明

    • Author(s)
      齋藤秀之、西一彦
    • Organizer
      第57回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-07-03 – 2014-07-05
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Presentation] 硫酸転移酵素(SULT)阻害薬によるインドキシル硫酸(IS)蓄積抑制と急性腎障害低減効果の検証

    • Author(s)
      野村祐依、西郷智香、佐潟雅隆、松永里香、城野博史、西一彦、齋藤秀之
    • Organizer
      第57回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-07-03 – 2014-07-05
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Presentation] 硫酸転移酵素(SULT)阻害薬によるインドキシル硫酸(IS)蓄積抑制と急性腎障害低減効果の検証

    • Author(s)
      野村祐依、西郷智香、佐潟雅隆、松永里香、城野博史、西一彦、齋藤秀之
    • Organizer
      第57回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-07-03 – 2014-07-05
    • Data Source
      KAKENHI-PROJECT-25670080
  • [Presentation] Meclofenamate elicits a nephropreventing effect in a rat model of ischemic acute kidney injury (AKI) by suppressing indoxyl sulfate (IS) production and restoring renal organic anion transporters

    • Author(s)
      Yoneda G, Nomura Y, Saigo C, Yamamoto Y, Jono H, Saito H
    • Organizer
      ・2014 American Society of Nephrology Annual Meeting
    • Place of Presentation
      Philadelphia、USA
    • Year and Date
      2014-11-11 – 2014-11-16
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Presentation] ワークショップ1・尿毒素から見たCKDの病態と治療「肝硫酸転移酵素SULTを標的とするインドキシル硫酸産生阻害薬の腎保護作用と機序解明

    • Author(s)
      齋藤秀之、西一彦
    • Organizer
      第57回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-07-03 – 2014-07-05
    • Invited
    • Data Source
      KAKENHI-PROJECT-25670080
  • [Presentation] 腎線維化に対する新規慢性炎症制御因子CYLD機能低下の臨床的意義の解明

    • Author(s)
      米田剛、末永尚輝、薮内希、西一彦、齋藤秀之、城野博史
    • Organizer
      第31回日本薬学会九州支部大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-12-06 – 2014-12-07
    • Data Source
      KAKENHI-PROJECT-25670080
  • [Presentation] 虚血再灌流急性腎障害ラットにおけるメクロフェナム酸の腎保護効果

    • Author(s)
      西郷智香、野村結衣、米田剛、山本悠子、城野博史、齋藤秀之
    • Organizer
      第8回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2014-11-15 – 2014-11-16
    • Data Source
      KAKENHI-PROJECT-25293040
  • [Presentation] Meclofenamate elicits a nephropreventing effect in a rat model of ischemic acute kidney injury (AKI) by suppressing indoxyl sulfate (IS) production and restoring renal organic anion transporters

    • Author(s)
      Yoneda G, Nomura Y, Saigo C, Yamamoto Y, Jono H, Saito H
    • Organizer
      ・2014 American Society of Nephrology Annual Meeting
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2014-11-11 – 2014-11-16
    • Data Source
      KAKENHI-PROJECT-25670080
  • []

  • 1.  INUI Kenーichi (70034030)
    # of Collaborated Projects: 16 results
    # of Collaborated Products: 0 results
  • 2.  KATSURA Toshiya (10283615)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 3.  MASUDA Satohiro (90303825)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 4.  OKUDA Masahiro (70252426)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 5.  HAMADA Akinobu (00322313)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 46 results
  • 6.  YANO Ikuko (50273446)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 7.  KAWAGUCHI Tatsuya (50244116)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 14 results
  • 8.  JONO Hirofumi (40515483)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 85 results
  • 9.  HASHIMOTO Yukiya (90228429)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  SASAKI Ji-ichiro (60419637)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 6 results
  • 11.  NONOGUCHI Hiroshi (30218341)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 12.  MATSUMOTO Mitsuhiro (70253755)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 13.  WATANABE Hiroshi (70398220)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 14.  TERADA Tomohiro (10324641)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  TAKANO Mikihisa (20211336)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  ANDO Yuichi (10360083)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 17.  SHIRAKI Nobuaki (70448520)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  MOTOHASHI Hideyuki (30359822)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  FUKATSU Atsushi (90247685)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  西 一彦 (30264287)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 16 results
  • 21.  大槻 純男 (60323036)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  松井 啓隆 (60379849)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  林 光博 (50735628)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 24.  成田 勇樹 (40614665)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 25.  SAIGO Chika
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 12 results
  • 26.  SAGATA Masataka
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 27.  SHINRIKI Satoru
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 28.  YASUOKA Yukiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  HIDE Takuichiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  河原 克雅
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  尾田 一貴
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 32.  向山 政志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  満屋 裕明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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