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SAKAI Hideaki  坂井 英昭

ORCIDConnect your ORCID iD *help
Researcher Number 40225769
External Links
Affiliation (based on the past Project Information) *help 2001: Nagasaki University、Associate Professor, 歯学部, 助教授
1995 – 1999: 長崎大学, 歯学部, 助教授
1992: 長崎大学, 歯学部・歯科薬理学講座, 助手
1990 – 1991: 長崎大学, 歯学部, 助手
Review Section/Research Field
Principal Investigator
Functional basic dentistry
Except Principal Investigator
Functional basic dentistry
Keywords
Principal Investigator
アポトーシス / 破骨細胞 / カテプシンE / 小胞体 / osteoclast / nitric oxide (NO) / fluorescence substrate / apoptosis / caspase / プロテアーゼ … More / MNA / 一酸化チッ素(NO) / 蛍光基質 / カスパーゼ / proteasome / tunicamycin / cathepsin E / oligosaccharide side chain / quality control / protein / カテプシン / 細胞内蛋白質輸送 / プロテアソーム / ツニカマイシン / 糖鎖 / クオリティーコントロール / タンパク質 / 破骨細胞分化因子(ODF) / Osteoprotegerin(OPG) / プロテインキナーゼC / TNFスーパーファミリー蛋白質 / ストローマ細胞 / nascent-polypeptide / クロスリンキング / リボソーム / NAC / タンパク質分解 … More
Except Principal Investigator
カテプシンE / カテプシンD / プロセシング / 生合成 / カテプシンB / Shedding / RANKL / Osteoprotegerin (OPG) / Osteoclast / Metalloprotease / Glycolipid / メタロプロテアーゼ / プロセッシング / ODF / 破骨細胞 / 細胞内アスパラギン酸プロテアーゼ / 胸腺細胞 / ミクログリア / リソゾ-ム性酵素 / Processing Enzyme / _D-PDMP / ADAM / OPG / プロセッシング酵素 / ODF(RANKL) / Processing enzyme / D-PDMP / metalloprotease-disintegrins / osteoprotegerin (OPG) / osteoclast differentiation factor (ODF) / shedding / osteoclast / 遺伝子 / PCR. / 融合 / プロテアーゼ / メタロプロテアーゼ-ディスインテグリン / オステオプロテグリン(OPG) / 破骨細胞分化因子(ODF) / シェディング(shedding) / Enzyme Immunnorssay / N-terminal Osteocalcin / Intact Osteocalcin / Osteocalcin / Rat / カルシトニン / 日周期性 / osteocalcin / デオキシピリジノリン / ピリジノリン / 骨吸収 / 骨形成 / カテプシンL / 酵素免疫測定法 / N末端オステオカルシン / 完全分子型オステオカルシン / オステオカルシン / ラット / Cathepsin E / Cathepsin D / Cathepsin B / Lysosomal enzymes / Maturation ameloblasts / クロロキン / リソゾーム性酵素 / 成熟期エナメル芽細胞 / マクロファージ / ノックアウト / 細胞内輸送 / CHO細胞 / フレンド細胞 / アスパラギン酸プロテアーゼ / ディフィレンシャル ディスプレー / mRNA / PCR / ディフィレッシャル ディスプレー / エナメル芽細胞 / 選別輸送機構 / メダラシン / カテプシンH / プロテア-ゼ / 細胞内プロテア-ゼ Less
  • Research Projects

    (14 results)
  • Co-Researchers

    (14 People)
  •  エンドソーム・リソソーム系蛋白分解機構におけるカテプシンEの役割

    • Principal Investigator
      山本 健二
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyushu University
  •  Design and application of new fluoroescent substrate against membrane-bound processing enzyme

    • Principal Investigator
      KATO Yuzo
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      NAGASAKI UNIVERSITY
  •  エンドソーム・リソソーム系蛋白分解機構におけるカテプシンEの役割

    • Principal Investigator
      山本 建二
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyushu University
  •  破骨細胞の死を遅延させるTNFスーパーファミリータンパク質の機能発現様式Principal Investigator

    • Principal Investigator
      坂井 英昭
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Nagasaki University
  •  A novel method for fluorescence microscopic demonstration of caspase activityPrincipal Investigator

    • Principal Investigator
      SAKAI Hideaki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Nagasaki University School of Dentistry
  •  NACのリボソーム上でのオン・オフ機構Principal Investigator

    • Principal Investigator
      坂井 英昭
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagasaki University
  •  Roles of metalloprotease-disintegrins in osteoclastogenesis

    • Principal Investigator
      KATO Yuzo
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Nagasaki University School of Dentistry
  •  細胞内アスパラギン酸プロテアーゼの機能構造形成と細胞機能制御

    • Principal Investigator
      山本 健二
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  エナメル芽細胞におけるRNAフィンガーブリンティング

    • Principal Investigator
      加藤 有三
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Functional basic dentistry
    • Research Institution
      Nagasaki University
  •  Quality control mechanism for secretory proteins in intracellular protein sorting pathwayPrincipal Investigator

    • Principal Investigator
      SAKAI Hideaki
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Nagasaki University
  •  小胞体内タンパク質分解機構のin vitro再構成に関する研究Principal Investigator

    • Principal Investigator
      坂井 英昭
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Nagasaki University
  •  Significance of osteocalcin in bone metabolism

    • Principal Investigator
      MATAKI Shiro
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Nagasaki University
  •  STUDIES ON FUNCTION OF LYSOSOMAL ENZYMES IN MATURATION AMELOBLASTS IN RAT

    • Principal Investigator
      MATAKI Shiro
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      DEPARTMENT OF PHARMACOLOGY, NAGASAKI UNIVERSITY SCHOOL OF DENTISTRY
  •  硬組織に由来する細胞の機能発現とリソゾ-ム性酵素の役割に関する実験薬理学的研究

    • Principal Investigator
      KATO Yuzo
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Nagasaki University
  • 1.  KATO Yuzo (20014128)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 2.  SAKAI Eiko (10176612)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 3.  山本 健二 (40091326)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  OZAKI Miho (50191341)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  中西 博 (20155774)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  MATAKI Shiro (80157221)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  KOBAYASHI Yasuhiro (20264252)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  NISHISHITA Kazuhisa (20237697)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  SHIBATA Mitsue (20274665)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  筑波 隆幸 (30264055)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  AWAYA Akira
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  MATSUDA Naoki (00304973)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  朔 敬 (40145264)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  高木 浩司 (40244074)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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