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Ohtsuka Takashi  大塚 崇

… Alternative Names

OHTSUKA Takashi  大塚 崇

大塚 崇  オオツカ タカシ

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Researcher Number 40306717
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-8039-9159
Affiliation (Current) 2025: 東京慈恵会医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2018 – 2025: 東京慈恵会医科大学, 医学部, 教授
2016 – 2017: 慶應義塾大学, 医学部(信濃町), 准教授
2015: 慶應義塾大学, 医学部, 准教授
2011 – 2014: 慶應義塾大学, 医学部, 講師
2002: 慶應大, 医学部, 助手
2000 – 2001: 慶應義塾大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Basic Section 55040:Respiratory surgery-related / Respiratory surgery / Thoracic surgery / Thoracic surgery
Except Principal Investigator
Respiratory surgery / Basic Section 49030:Experimental pathology-related / Basic Section 55040:Respiratory surgery-related / Basic Section 55010:General surgery and pediatric surgery-related / Experimental pathology / General surgery / Thoracic surgery
Keywords
Principal Investigator
肺移植 / 拒絶反応 / 急性肺障害 / 一酸化炭素 / 間葉系幹細胞 / 肺虚血再灌流障害 / T細胞 / 肺サイトカイン / 肺虚血再灌流 / 肺由来間葉系幹細胞 … More / lung transplantation / mesenchymal stem cell / acute lung injury / 移植 / 制御性T細胞 / T細胞 / 肺移植拒絶反応 / マトリックスメタロプロテアーゼ / メタロプロテアーゼ / マイクロソフィア / 血管新生 / 人工酸素運搬体 / 血管新生抑制物質 … More
Except Principal Investigator
プロテアーゼ / 線維芽細胞 / 人工酸素運搬体 / 肺損傷 / 細胞外マトリックス / 空間的発現解析 / 腫瘍免疫 / がん微小環境 / 肺癌 / 医工連携 / 末梢気道 / ファイバースコープ / 心臓移植 / 虚血再灌流傷害 / 人工ガス運搬体 / 心移植 / がん関連線維芽細胞 / エピゲノム / 網羅的解析 / 腫瘍間質 / がん / radiation / chemotherapy / artificial oxygen carrier / Ly-80 / tumor / rat / 補助科学療法 / 動脈内注入 / 腫瘍循環 / 腫瘍内酸素分圧 / LK-80 / 放射線療法 / 抗癌剤 / LY-80 / 腫瘍 / ラット / オートファジー / ビスフォスフォネート / ゾレドロン酸 / 悪性胸膜中皮腫 / ヘモグロビン小胞体 / 呼吸不全 / 肺切除 / 出血性ショック / 外科手術 / 人工赤血球 / Eセレクチン / E-selectin / 肺線維症 / 可溶性分画 / 動物モデル / 好中球 / セレクチン / 急性肺損傷 / 肺移植 Less
  • Research Projects

    (15 results)
  • Research Products

    (20 results)
  • Co-Researchers

    (29 People)
  •  急性肺障害の肺由来間葉系幹細胞による治療と極細径気管支鏡による診断モデルの開発Principal Investigator

    • Principal Investigator
      大塚 崇
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Jikei University School of Medicine
  •  Development of new technologies for observation, biopsy, and treatment of peripheral airway lesions by medical-engineering collaboration

    • Principal Investigator
      木下 智成
    • Project Period (FY)
      2024 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Jikei University School of Medicine
  •  個細胞空間的degradome解析に基づくプロテアーゼを介したがん免疫制御の解明

    • Principal Investigator
      下田 将之
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Jikei University School of Medicine
  •  Amelioration of acute lung injury by lung mesenchymal stem cell and carbon monoxide.Principal Investigator

    • Principal Investigator
      Ohtsuka Takashi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Jikei University School of Medicine
  •  Establishment of a new method using carbon monoxide aiming at long-term preservation of donor heart for heart transplantation

    • Principal Investigator
      Kimura Naritaka
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Keio University
  •  Amelioration of rejection after lung transplant by newly developed gas carrier.Principal Investigator

    • Principal Investigator
      Ohtsuka Takashi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory surgery
    • Research Institution
      Jikei University School of Medicine
      Keio University
  •  Analysis of cancer-associated fibroblasts from the perspective of proteinases and epigenetics

    • Principal Investigator
      SHIMODA MASAYUKI
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Keio University
  •  Ameliorating bronchiolitis oblietrans after transplantation using hemoglobin vesicles by controlling ADAM/MMP expressions.Principal Investigator

    • Principal Investigator
      Ohtsuka Takashi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory surgery
    • Research Institution
      Keio University
  •  The cytostatic effects of zoledronic acid on ACC-MESO-1 cells

    • Principal Investigator
      Asakura Keisuke
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory surgery
    • Research Institution
      Keio University
  •  Effect of oxygen infusion with hemoglobin vesicles on respiratory insufficiency

    • Principal Investigator
      KOHNO Mitsutomo
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory surgery
    • Research Institution
      Tokai University
      Keio University
  •  Involvement of E-selectin in reimplantation lung injury

    • Principal Investigator
      GOTO Taichiro
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Thoracic surgery
    • Research Institution
      Keio University
  •  The effect of Carbon monoxide and Adenosine receptor in bronchiolitis obliterans in mice trachea transplantation model.Principal Investigator

    • Principal Investigator
      OHTSUKA Takashi
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Thoracic surgery
    • Research Institution
      Keio University
  •  肺癌の浸潤、転移におけるプロテアーゼの関与の研究Principal Investigator

    • Principal Investigator
      大塚 崇
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Thoracic surgery
    • Research Institution
      Keio University
  •  Tumor sensitization to chemotherapy of radiation by artificial oxygen carriers

    • Principal Investigator
      KOBAYASHI Koichi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      KEIO UNIVERSITY
  •  人工酸素運搬体と血管新生抑制物質の併用による腫瘍抑制効果の測定Principal Investigator

    • Principal Investigator
      大塚 崇
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Thoracic surgery
    • Research Institution
      Keio University

All 2020 2019 2015 2014 2013 2012 2011

All Journal Article Presentation

  • [Journal Article] Simultaneous 2D and 3D simulation of thoracoscopic sleeve lobectomy: a quick understanding pitfalls2020

    • Author(s)
      Nakada Takeo、Noda Yuki、Kato Daiki、Mori Shohei、Asano Hisatoshi、Matsudaira Hideki、Ohtsuka Takashi
    • Journal Title

      The Annals of Thoracic Surgery

      Volume: 印刷中 Issue: 5 Pages: e383-e385

    • DOI

      10.1016/j.athoracsur.2019.11.055

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08581
  • [Journal Article] Infiltration of tumor‐associated macrophages is involved in tumor programmed death‐ligand 1 expression in early lung adenocarcinoma2020

    • Author(s)
      Shima Toshiyuki、Shimoda Masayuki、Shigenobu Takao、Ohtsuka Takashi、Nishimura Tomoyasu、Emoto Katsura、Hayashi Yuichiro、Iwasaki Tatsuro、Abe Takayuki、Asamura Hisao、Kanai Yae
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 2 Pages: 727-738

    • DOI

      10.1111/cas.14272

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08581, KAKENHI-PROJECT-19K07422, KAKENHI-PROJECT-17K10800
  • [Journal Article] Risk factors and cancer recurrence associated with postoperative complications after thoracoscopic lobectomy for clinical stage I non‐small cell lung cancer2019

    • Author(s)
      Nakada Takeo、Noda Yuki、Kato Daiki、Shibasaki Takamasa、Mori Shohei、Asano Hisatoshi、Matsudaira Hideki、Hirano Jun、Odaka Makoto、Ohtsuka Takashi
    • Journal Title

      Thoracic Cancer

      Volume: 10 Issue: 10 Pages: 1945-1952

    • DOI

      10.1111/1759-7714.13173

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08581
  • [Journal Article] Recovery of pulmonary function after lung wedge resection2019

    • Author(s)
      Mori Shohei、Shibazaki Takamasa、Noda Yuki、Kato Daiki、Nakada Takeo、Asano Hisatoshi、Matsudaira Hideki、Ohtsuka Takashi
    • Journal Title

      Journal of Thoracic Disease

      Volume: 11 Issue: 9 Pages: 3738-3745

    • DOI

      10.21037/jtd.2019.09.32

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08581
  • [Journal Article] Risk factors for recurrence of primary spontaneous pneumothorax after thoracoscopic surgery2019

    • Author(s)
      Asano Hisatoshi、Ohtsuka Takashi、Noda Yuki、Kato Daiki、Mori Shohei、Nakada Takeo、Matsudaira Hideki
    • Journal Title

      Journal of Thoracic Disease

      Volume: 11 Issue: 5 Pages: 1940-1944

    • DOI

      10.21037/jtd.2019.04.105

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08581
  • [Journal Article] Involvement of GPx4-Regulated Lipid Peroxidation in Idiopathic Pulmonary Fibrosis Pathogenesis2019

    • Author(s)
      Tsubouchi K、Araya J、Yoshida M、Sakamoto T、Koumura T、Minagawa S、Hara H、Hosaka Y、Ichikawa A、Saito N、Kadota T、Kurita Y、Kobayashi K、Ito S、Fujita Y、Utsumi H、Hashimoto M、Wakui H、Numata T、Kaneko Y、Mori S、Asano Hi、Matsudaira H、Ohtsuka T、Nakayama K、Nakanishi Y、Imai H、Kuwano K
    • Journal Title

      The Journal of Immunology

      Volume: 203 Issue: 8 Pages: 2076-2087

    • DOI

      10.4049/jimmunol.1801232

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08188, KAKENHI-PROJECT-18K08581, KAKENHI-PROJECT-18K14906
  • [Journal Article] Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis2019

    • Author(s)
      Saito N、Araya J、Ito S、Tsubouchi K、Minagawa S、Hara H、Ito A、Nakano T、Hosaka Y、Ichikawa A、Kadota T、Yoshida M、Fujita Y、Utsumi H、Kurita Y、Kobayashi K、Hashimoto M、Wakui H、Numata T、Kaneko Y、Asano H、Odaka M、Ohtsuka T、Morikawa T、Nakayama K、Kuwano K.
    • Journal Title

      The Journal of Immunology

      Volume: 202 Issue: 5 Pages: 1428-1440

    • DOI

      10.4049/jimmunol.1801293

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08188, KAKENHI-PROJECT-18K08581
  • [Journal Article] The prevention of tracheal graft occlusion using pioglitazone: A mouse tracheal transplant model study.2019

    • Author(s)
      Shigenobu T, Ohtsuka T ,Shimoda M
    • Journal Title

      Transplant Immunology

      Volume: 53 Pages: 21-27

    • DOI

      10.1016/j.trim.2018.12.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10800, KAKENHI-PROJECT-18K08581
  • [Journal Article] Demographics, Safety and Quality, and Prognostic Information in Both the Seventh and Eighth Editions of the TNM Classification in 18,973 Surgical Cases of the Japanese Joint Committee of Lung Cancer Registry Database in 20102019

    • Author(s)
      Okami Jiro、Shintani Yasushi、Okumura Meinoshin、Ito Hiroyuki、Ohtsuka Takashi、Toyooka Shinichi、Mori Takeshi、Watanabe Shun-ichi、Date Hiroshi、Yokoi Kohei、Asamura Hisao、Nagayasu Takeshi、Miyaoka Etsuo、Yoshino Ichiro
    • Journal Title

      Journal of Thoracic Oncology

      Volume: 14 Issue: 2 Pages: 212-222

    • DOI

      10.1016/j.jtho.2018.10.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08581
  • [Journal Article] Attenuation of lung ischemia-reperfusion injury by Rho-associated kinase inhibition in a rat model of lung transplantation.2014

    • Author(s)
      Kohno M, Watanabe M, Goto T, Kamiyama I, Ohtsuka T, Tasaka S, Sawafuji M.
    • Journal Title

      Annals of thoracic and cardiovascular surgery

      Volume: 未定

    • NAID

      130003387995

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25462183
  • [Presentation] Pioglitazone Induces Infiltrations of Regulatory T Cells in the Tracheal Graft and Attenuates Allograft Rejection2019

    • Author(s)
      Takashi Ohtsuka
    • Organizer
      International society for heart and lung transplantation
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10800
  • [Presentation] Peroxisome proliferator-activated receptor(PPAR)-γアゴニストによるマウス気管移植での拒絶反応抑制2019

    • Author(s)
      大塚 崇
    • Organizer
      第119回日本外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-17K10800
  • [Presentation] Pioglitazone induces infiltrations of regulatory T cells in the tracheal graft and attenuates allograft rejection.2019

    • Author(s)
      Takashi Ohtsuka
    • Organizer
      39th annual meeting of International society of heart and lung transplantation
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10800
  • [Presentation] Peroxisome proliferator-activated receptor(PPAR)-γアゴニストによるマウス気管移植での拒絶反応抑制2019

    • Author(s)
      大塚 崇
    • Organizer
      第119回 日本外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-17K10800
  • [Presentation] Pioglitazone投与による気管移植動物モデルの拒絶反応抑制,FoxP3陽性細胞の集積2015

    • Author(s)
      重信敬夫 大塚 崇
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2015-04-15
    • Data Source
      KAKENHI-PROJECT-26462134
  • [Presentation] Pioglitazone投与による期間移植動物モデルの拒絶反応抑制、FoxP3陽性細胞の集積2015

    • Author(s)
      重信敬夫、大塚 崇
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-15
    • Data Source
      KAKENHI-PROJECT-26462134
  • [Presentation] CORM-2のBOに対する抑制効果2013

    • Author(s)
      大塚 崇
    • Organizer
      日本呼吸器外科学会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23791577
  • [Presentation] Carbon Monoxide-Releasing Molecule Attenuates Allograft Airway Rejection2012

    • Author(s)
      大塚 崇
    • Organizer
      International society of Heart and Lung transplantation
    • Place of Presentation
      チェコ プラハ
    • Data Source
      KAKENHI-PROJECT-23791577
  • [Presentation] Wate-soluble carbon monoxide-releasing molecule attenuates allograft airway rejection2012

    • Author(s)
      Takashi Ohtsuka, Taichiro Goto, Masaki Anraku, Mitsutomo Kohno, Hiroaki Nomori
    • Organizer
      International society of heart and lung transplantation
    • Place of Presentation
      プラハ チェコ
    • Year and Date
      2012-04-17
    • Data Source
      KAKENHI-PROJECT-23791577
  • [Presentation] マウス気管移植(同所と異所)によるbronchiolitis obliterans モデルの検討Tracheal allograft oblitaration in a murine tracheal transplant model2011

    • Author(s)
      大塚 崇、後藤太一郎、安樂 真樹、河野 光智、泉 陽太郎、堀之内宏久、野守 裕明
    • Organizer
      第64回日本胸部外科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-09
    • Data Source
      KAKENHI-PROJECT-23791577
  • 1.  SHIMODA MASAYUKI (70383734)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 1 results
  • 2.  TAKAHASHI Yusuke (00445214)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  ANRAKU Masaki (70598557)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  KOHNO Mitsutomo (10276272)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 5.  WATANABE Masazumi (90201227)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 6.  GOTO Taichiro (80317148)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  OKUI Masayuki (30594494)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  SAKAI Hiromi (70318830)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  Asakura Keisuke (90383786)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  KOBAYASHI Koichi (80051704)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  KAWAMURA Masafumi (70169770)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  HORINOUCHI Hirohisa (60173647)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  SHIGEMATSU Naoyuki (30178868)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  YAMAMOTO Manabu (10317159)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  Kimura Naritaka (90348657)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  羽藤 泰 (10365281)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  重信 敬夫 (50626702)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  涌井 昌俊 (90240465)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  山内 徳子 (30306732)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  橋本 浩平 (70464964)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  木下 智成 (30573406)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  浦野 泰照 (20292956)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  岡 潔 (80354661)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  久保 健一郎 (20348791)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  西村 知泰 (90348649)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  KANAI Yae
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  OKADA Yasunori
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  ARAYA Jun
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 29.  中山 勝敏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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