CHIBA HIROFUMI 千葉弘文

… Alternative Names

Chiba Hirofumi 千葉弘文

CHIBA Hirofumi 千葉弘文

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Researcher Number	40347175
Other IDs
External Links
Affiliation (Current)	2025: 札幌医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2025: 札幌医科大学, 医学部, 教授 2021 – 2023: 札幌医科大学, 医学部, 教授 2016 – 2020: 札幌医科大学, 医学部, 准教授 2013: 札幌医科大学, 医学部, 講師 2010: 札幌医科大学, 医学部, 助教 2002 – 2005: Sapporo Medical University School of Medicine, Third Department of Internal medicine, Instructor, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine / Respiratory organ internal medicine Except Principal Investigator Respiratory organ internal medicine / Basic Section 53030:Respiratory medicine-related
Keywords	Principal Investigator 肺サーファクタント蛋白質 / 自然免疫 / 急性増悪 / マイクロバイオーム / 特発性肺線維症 / sarcoidosis / Th1 cytokine / osteopontin / 肺サーファクタント蛋白 / ディスバイオーシス … More / ディスバイオシス / Thl cytokine / サーファクタントプロテイン / Toll like receptor / マイコプラズマ / 気管支喘息 / CD14 / toll like receptor / lipoprotein / surfactant protein A / mycoplasma … More Except Principal Investigator Toll-like receptor / SP-A / 肺サーファクタント / 肺サーファクタント蛋白質 / トル様受容体 / 肺コレクチン / ブレオマイシン / 肺傷害 / MD-2 / SP-D / lipoprotein / Mycoplasma pneumoniae / peptidoglycan / Staphylococcus aureus / Toll様受容体 / 間質性肺炎 / 肺サーファクタントタンパク質A / 薬剤性肺障害 / マイクロバイオーム解析 / マイクロバイオーム / 肺内微生物叢 / 肺マイクロバイオーム / 自然免疫 / 免疫学 / 内科 / 抗線維化 / 抗炎症 / アレルギー性気道炎症 / 急性肺傷害 / endotoxin / phagocytic receptor / collectin / pulmonary surfactant proteins / CD14 / 非定型抗酸菌 / スカベンジャー受容体 / エンドトキシン / 貪食受容体 / コレクチン / alveolar macrophage / surfactant protein A / interstitial pneumonia / TNF-α / 肺胞マクロファージ / サーファクタント蛋白質-A / 急性肺障害 / 肺線維化 / ノックアウトマウス / TLR2 / 肺サーファクタント蛋白質A Less

自然免疫機構に着目した肺線維化病態の探索Principal Investigator
- Principal Investigator
  
  千葉弘文
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Sapporo Medical University
肺マイクロバイオームの変容と自然免疫応答異常に注目したIPF病態の解明Principal Investigator
- Principal Investigator
  
  千葉弘文
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Sapporo Medical University
Loss of lung microbiome diversity and immune mechanisms of pulmonary surfactant proteins
- Principal Investigator
  
  Kuronuma Koji
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Sapporo Medical University
Elucidation of the pathophysiology of acute exacerbation of IPF based on lung microbiome analysis and development of innovative treatment strategiesPrincipal Investigator
- Principal Investigator
  
  Chiba Hirofumi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Sapporo Medical University
Pulmonary fibrosis treatment with pulmonary surfactant as a TLR regulatory molecule and HSP47 inhibition
- Principal Investigator
  
  Takahashi Hiroki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Suppression of pulmonary injury and fibrosis by applying new action of pulmonary surfactant protein
- Principal Investigator
  
  TAKAHASHI HIROKI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Therapeutic application of lung collectin in acute lung injury
- Principal Investigator
  
  TAKAHASHI HIROKI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Pulmonary collectin regulates drug-induced lung injury.
- Principal Investigator
  
  TAKAHASHI Hiroki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Mechanisms of innate immune surveillance by pulmonary surfactant proteins and their clinical application to respiratory infection.
- Principal Investigator
  
  KUROKI Yoshio
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
気管支喘息の増悪因子としてのマイコプラズマ感染とTLRの関与Principal Investigator
- Principal Investigator
  
  千葉弘文
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Regulation of TLR by surfactant proteins in interstitial pneumonia
- Principal Investigator
  
  TAKAHASHI Hiroki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University School of Medicine
Investigation of induction of Th1 cytokines by osteopontin in granulomatous lung diseasesPrincipal Investigator
- Principal Investigator
  
  CHIBA Hirofumi, 四十坊典晴
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University School of Medicine

[Book] インフォームドコンセントのための図解シリーズ　びまん性肺疾患と特発性肺炎．2014
- Author(s)
  高橋弘毅、千葉弘文、大塚満雄
- Total Pages
  136
- Publisher
  医薬ジャーナル
- Data Source
  KAKENHI-PROJECT-26461164
[Book] 総論治療1.生活習慣と薬物療法.監修.インフォームドコンセントのための図解シリーズびまん性肺疾患と特発性肺炎2014
- Author(s)
  高橋弘毅、千葉弘文、大塚満雄
- Publisher
  東京 : 医薬ジャーナル
- Data Source
  KAKENHI-PROJECT-23591154
[Book] Annual Rewiew 呼吸器2010(III. 診断の進歩:3.肺線維症におけるバイオマーカーの最近の知見)(永井厚志他編)東京2010
- Author(s)
  高橋弘毅、白鳥正典、千葉弘文
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-20590930
[Journal Article] Serum Testosterone Is Associated With the Severity of COVID-19.2023
- Author(s)
  Suzuki E, Kuronuma K, Murai R, Fujiya Y, Saito A, Chiba H, Takahashi S.
- Journal Title
  
  In Vivo.
  
  Volume: 37 Issue: 5 Pages: 2314-2319
- DOI
  10.21873/invivo.13334
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07656, KAKENHI-PROJECT-20K08570
[Journal Article] Pseudo-outbreak of Mycobacterium lentiflavum at a general hospital in Japan2023
- Author(s)
  Nagano Yutaro、Kuronuma Koji、Kitamura Yasuo、Nagano Kanami、Yabe Hayato、Kudo Sayaka、Sato Toyotaka、Nirasawa Shinya、Nakae Mami、Horiuchi Motohiro、Yokota Shin-ichi、Fujiya Yoshihiro、Saito Atsushi、Takahashi Satoshi、Chiba Hirofumi
- Journal Title
  
  Infection Control & Hospital Epidemiology
  
  Volume: 44 Issue: 11 Pages: 1809-1815
- DOI
  10.1017/ice.2023.68
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19416, KAKENHI-PROJECT-23K07656, KAKENHI-PROJECT-20K08570, KAKENHI-PROJECT-21H03622, KAKENHI-PROJECT-23K23772
[Journal Article] Protective effect of <i>Bifidobacterium longum</i> BB536 against nausea caused by pirfenidone in a mouse model of pellagra2023
- Author(s)
  Kuronuma K, Susai N, Kuroita T, Yoshioka T, Saito A, Chiba H.
- Journal Title
  
  Bioscience of Microbiota, Food and Health
  
  Volume: 42 Issue: 3 Pages: 195-202
- DOI
  10.12938/bmfh.2022-042
- ISSN
  2186-3342
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07656, KAKENHI-PROJECT-20K08570
[Journal Article] The Soluble Lectin Families as Novel Biomarkers for COVID-19 Pneumonia.2023
- Author(s)
  Takenaka H, Saito A, Kuronuma K, Moniwa K, Nishikiori H, Takahashi S, Chiba H.
- Journal Title
  
  In Vivo.
  
  Volume: 37 Issue: 4 Pages: 1721-1728
- DOI
  10.21873/invivo.13259
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07656, KAKENHI-PROJECT-20K08570
[Journal Article] Analysis of real-world data and a mouse model indicates that pirfenidone causes pellagra.2023
- Author(s)
  Kuronuma K, Susai N, Kuroita T, Yamamoto H, Yoshioka T, Kaneko S, Chiba H.
- Journal Title
  
  ERJ Open Res.
  
  Volume: 8 Issue: 4 Pages: 00245-2022
- DOI
  10.1183/23120541.00245-2022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08570
[Journal Article] Deep learning algorithm to detect fibrosing interstitial lung disease on chest radiographs.2023
- Author(s)
  Nishikiori H, Kuronuma K, Hirota K, Yama N, Suzuki T, Onodera M, Onodera K, Ikeda K, Mori Y, Asai Y, Takagi Y, Honda S, Ohnishi H, Hatakenaka M, Takahashi H, Chiba H.
- Journal Title
  
  Eur Respir J.
  
  Volume: 61 Issue: 2 Pages: 2102269-2102269
- DOI
  10.1183/13993003.02269-2021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08570, KAKENHI-PROJECT-23K07656
[Journal Article] Development of a new HISCL automated CXCL9 immunoassay.2023
- Author(s)
  Hasegawa T, Yoshida M, Watanabe S, Kondo T, Asada H, Nakagawa A, Tomii K, Kameda M, Otsuka M, Kuronuma K, Chiba H, Katayanagi S, Miyazaki Y, Mori A.
- Journal Title
  
  Sci Rep.
  
  Volume: 13 Issue: 1 Pages: 5342-5342
- DOI
  10.1038/s41598-023-32513-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07656, KAKENHI-PROJECT-20K08570, KAKENHI-PROJECT-21K08306, KAKENHI-PROJECT-21K08486
[Journal Article] Role of transient receptor potential vanilloid 4 in therapeutic antifibrotic effects of pirfenidone.2022
- Author(s)
  Kuronuma K, Otsuka M, Wakabayashi M, Yoshioka T, Kobayashi T, Kameda M, Morioka Y, Chiba H, Takahashi H.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol.
  
  Volume: 323 Issue: 2 Pages: L193-L205
- DOI
  10.1152/ajplung.00565.2020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08570
[Journal Article] N-glycosylation regulates MET processing and signaling2022
- Author(s)
  Atsushi Saitou, Yoshihiro Hasegawa, Naoki Fujitani, Shigeru Ariki, Yasuaki Uehara, Ukichiro Hashimoto, Atsushi Saito, Koji Kuronuma, Kunio Matsumoto, Hirofumi Chiba, Motoko Takahashi
- Journal Title
  
  Cancer Science
  
  Volume: ー Issue: 4 Pages: 1292-1304
- DOI
  10.1111/cas.15278
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17218, KAKENHI-PROJECT-20K22880, KAKENHI-PROJECT-19H03499, KAKENHI-PROJECT-20K08521, KAKENHI-PROJECT-20K08570, KAKENHI-PROJECT-21K08207, KAKENHI-PROJECT-21K18250, KAKENHI-PROJECT-21K06083
[Journal Article] Pneumocystis jirovecii Pneumonia Associated with COVID-19 in Patients with Interstitial Pneumonia.2022
- Author(s)
  Takahashi T, Saito A, Kuronuma K, Nishikiori H, Chiba H.
- Journal Title
  
  Medicina (Kaunas).
  
  Volume: 58 Issue: 9 Pages: 1151-1151
- DOI
  10.3390/medicina58091151
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08570
[Journal Article] Invasive pneumococcal disease affected the fatal outcome in a COVID-19 patient2021
- Author(s)
  Kuronuma Koji、Bunya Naofumi、Chang Bin、Fujiya Yoshihiro、Oishi Kazunori、Narimatsu Eichi、Takahashi Satoshi、Chiba Hirofumi
- Journal Title
  
  Journal of Infection and Chemotherapy
  
  Volume: - Issue: 7 Pages: 1108-1111
- DOI
  10.1016/j.jiac.2021.04.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08570
[Journal Article] Characteristics of COVID-19 patients admitted into two hospitals in sapporo, Japan: Analyses and insights from two outbreak waves2021
- Author(s)
  Hattori Takeshi、Saito Atsushi、Chiba Hirofumi、Kuronuma Koji、Amishima Masaru、Morinaga Daisuke、Shichinohe Yasuo、Nasuhara Yasuyuki、Konno Satoshi
- Journal Title
  
  Respiratory Investigation
  
  Volume: 59 Issue: 2 Pages: 180-186
- DOI
  10.1016/j.resinv.2020.11.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08521, KAKENHI-PROJECT-20K08570
[Journal Article] A modified GAP model for East-Asian populations with idiopathic pulmonary fibrosis2020
- Author(s)
  Nishikiori Hirotaka、Chiba Hirofumi、Lee Sang Hoon、Kondoh Shun、Kamo Ken-ichi、Nakamura Koshi、Ikeda Kimiyuki、Kuronuma Koji、Chung Man Pyo、Kondoh Yasuhiro、Homma Sakae、Inase Naohiko、Park Moo Suk、Takahashi Hiroki
- Journal Title
  
  Respiratory Investigation
  
  Volume: 58 Issue: 5 Pages: 395-402
- DOI
  10.1016/j.resinv.2020.04.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08570, KAKENHI-PROJECT-17H00806
[Journal Article] Respiratory reactance in forced oscillation technique reflects disease stage and predicts lung physiology deterioration in idiopathic pulmonary fibrosis2020
- Author(s)
  Mori Y、Nishikiori H、Chiba H、Yamada G、Kuronuma K、Takahashi H.
- Journal Title
  
  Respir Physiol Neurobiol
  
  Volume: 275 Pages: 103386-103386
- DOI
  10.1016/j.resp.2020.103386
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09662
[Journal Article] Surfactant protein A as a biomarker of outcomes of anti-fibrotic drug therapy in patients with idiopathic pulmonary fibrosis2020
- Author(s)
  Yoshikawa Takumi、Otsuka Mitsuo、Chiba Hirofumi、Ikeda Kimiyuki、Mori Yuki、Umeda Yasuaki、Nishikiori Hirotaka、Kuronuma Koji、Takahashi Hiroki
- Journal Title
  
  BMC Pulmonary Medicine
  
  Volume: 20 Issue: 1 Pages: 2727-2727
- DOI
  10.1186/s12890-020-1060-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09619, KAKENHI-PROJECT-17K09662, KAKENHI-PROJECT-18K08150
[Journal Article] CXCL9, CXCL10, and CXCL11; biomarkers of pulmonary inflammation associated with autoimmunity in patients with collagen vascular diseases?associated interstitial lung disease and interstitial pneumonia with autoimmune features2020
- Author(s)
  Kameda Masami、Otsuka Mitsuo、Chiba Hirofumi、Kuronuma Koji、Hasegawa Takehiro、Takahashi Hiroki、Takahashi Hiroki
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 11 Pages: e0241719-e0241719
- DOI
  10.1371/journal.pone.0241719
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08570
[Journal Article] Acute eosinophilic pneumonia accompanied with COVID ‐19: a case report2020
- Author(s)
  Murao Koutaro、Saito Atsushi、Kuronuma Koji、Fujiya Yoshihiro、Takahashi Satoshi、Chiba Hirofumi
- Journal Title
  
  Respirology Case Reports
  
  Volume: 8 Issue: 9
- DOI
  10.1002/rcr2.683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08521, KAKENHI-PROJECT-20K08570
[Journal Article] Aberrant populations of circulating T follicular helper cells and regulatory B cells underlying idiopathic pulmonary fibrosis2019
- Author(s)
  Asai Yuichiro、Chiba Hirofumi、Nishikiori Hirotaka、Kamekura Ryuta、Yabe Hayato、Kondo Shun、Miyajima Satsuki、Shigehara Katsunori、Ichimiya Shingo、Takahashi Hiroki
- Journal Title
  
  Respiratory Research
  
  Volume: 20 Issue: 1 Pages: 244-244
- DOI
  10.1186/s12931-019-1216-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08150, KAKENHI-PROJECT-18K09323, KAKENHI-PROJECT-18H02632, KAKENHI-PROJECT-17K09662
[Journal Article] Response to pneumococcal vaccine in interstitial lung disease patients: Influence of systemic immunosuppressive treatment2018
- Author(s)
  Kuronuma Koji、Honda Hiroyuki、Mikami Tessei、Saito Atsushi、Ikeda Kimiyuki、Otsuka Mitsuo、Chiba Hirofumi、Yamada Gen、Sato Toyotaka、Yokota Shin-ichi、Takahashi Hiroki
- Journal Title
  
  Vaccine
  
  Volume: 36 Issue: 33 Pages: 4968-4972
- DOI
  10.1016/j.vaccine.2018.06.062
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09619, KAKENHI-PROJECT-17K09662, KAKENHI-PROJECT-18K15956
[Journal Article] Significance of molecular biomarkers in idiopathic pulmonary fibrosis: A mini review2018
- Author(s)
  Chiba Hirofumi、Otsuka Mitsuo、Takahashi Hiroki
- Journal Title
  
  Respiratory Investigation
  
  Volume: 56 Issue: 5 Pages: 384-391
- DOI
  10.1016/j.resinv.2018.06.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09619, KAKENHI-PROJECT-17K09662
[Journal Article] Impaired diversity of the lung microbiome predicts progression of idiopathic pulmonary fibrosis2018
- Author(s)
  Takahashi Youhei、Saito Atsushi、Chiba Hirofumi、Kuronuma Koji、Ikeda Kimiyuki、Kobayashi Tomofumi、Ariki Shigeru、Takahashi Motoko、Sasaki Yasushi、Takahashi Hiroki
- Journal Title
  
  Respir Res
  
  Volume: 19 Issue: 1 Pages: 34-34
- DOI
  10.1186/s12931-018-0736-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09181, KAKENHI-PROJECT-16K19460, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-17K07339, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-17K09662, KAKENHI-PROJECT-18K08150
[Journal Article] Poorer Prognosis of Idiopathic Pleuroparenchymal Fibroelastosis Compared with Idiopathic Pulmonary Fibrosis in Advanced Stage2018
- Author(s)
  Shioya Makoto、Otsuka Mitsuo、Yamada Gen、Umeda Yasuaki、Ikeda Kimiyuki、Nishikiori Hirotaka、Kuronuma Koji、Chiba Hirofumi、Takahashi Hiroki
- Journal Title
  
  Canadian Respiratory Journal
  
  Volume: 2018 Pages: 1-7
- DOI
  10.1155/2018/6043053
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09619, KAKENHI-PROJECT-17K09662
[Journal Article] Treatment of pulmonary fibrosis with siRNA against a collagen-specific chaperone HSP47 in vitamin A-coupled liposomes.2017
- Author(s)
  Otsuka M, Shiratori M, Chiba H, Kuronuma K, Sato Y, Niitsu Y, Takahashi H.
- Journal Title
  
  Experimental Lung Research
  
  Volume: 43 Pages: 271-282
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09662
[Journal Article] Serum surfactant protein D predicts the outcome of patients with idiopathic pulmonary fibrosis treated with pirfenidone.2017
- Author(s)
  Ikeda K, Shiratori M, Chiba H, Nishikiori H, Yokoo K, Saito A, Hasegawa Y, Kuronuma K, Otsuka M, Yamada G, Takahashi H.
- Journal Title
  
  Respiratoru Medicine
  
  Volume: 131 Pages: 184-191
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09662
[Journal Article] Distinct compartmentalization of SP-A and SP-D in the vasculature and lungs of patients with idiopathic pulmonary fibrosis.2014
- Author(s)
  Nishikiori H, Chiba H, Ariki S, Kuronuma K, Otsuka M, Shiratori M, Ikeda K, Watanabe A, Kuroki Y, Takahashi H.
- Journal Title
  
  BMC Pulm Med.
  
  Volume: 14 Pages: 196-196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461164
[Journal Article] Epidemiologic survey of Japanese patients with idiopathic pulmonary fibrosis and investigation of ethnic differences.2014
- Author(s)
  Natsuizaka M, Chiba H, Kuronuma K, Otsuka M, Kudo K, Mori M, Bando M, Sugiyama Y, Takahashi H.
- Journal Title
  
  Am J Respir Crit Care Med.
  
  Volume: 190 Pages: 773-779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461164
[Journal Article] 特発性肺線維症患者におけるSP-AとSP-Dの肺内動態の差異ついての検討2013
- Author(s)
  織博貴, 千葉弘文, 大塚満雄, 高橋弘毅
- Journal Title
  
  日肺サーファクタント・界面医会誌
  
  Volume: 44 Pages: 63-5
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] 呼吸器疾患の診断・治療(I)間質性肺炎2013
- Author(s)
  千葉弘文, 高橋弘毅
- Journal Title
  
  医学と薬学
  
  Volume: 69(1) Pages: 27-32
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] 特発性肺線維症の疫学調査(北海道study)による新知見2013
- Author(s)
  千葉弘文, 夏井坂元基, 高橋弘毅
- Journal Title
  
  呼吸器内科
  
  Volume: 23(4) Pages: 337-41
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] 呼吸器疾患の診断と治療最近の進歩特発性間質性肺炎2013
- Author(s)
  千葉弘文, 高橋弘毅
- Journal Title
  
  北海道医報
  
  Volume: 1134 Pages: 44-6
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] 【特発性間質性肺炎-この10年の進歩と今後の展望-】特発性間質性肺炎の診断と治療の進歩診断・疫学関連わが国における疫学調査:北海道STUDY2013
- Author(s)
  千葉弘文, 夏井坂元基, 高橋弘毅
- Journal Title
  
  日胸
  
  Volume: 72
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] 間質性肺疾患Up-To-Date北海道studyはじめて明らかになった特発性肺線維症の疫学2012
- Author(s)
  千葉弘文, 夏井坂元基, 高橋弘毅
- Journal Title
  
  THE LUNG-perspective
  
  Volume: 20(3) Pages: 243-5
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] 特集特発性肺線維症(IPF). IPFのバイオマーカー2. SP-D, SP-A2011
- Author(s)
  高橋弘毅, 白鳥正典, 千葉弘文
- Journal Title
  
  呼吸器内科
  
  Volume: 19(6) Pages: 597-604
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] びまん性肺疾患のマイル・ストーン特発性肺線維症の病態と特徴2011
- Author(s)
  高橋弘毅, 千葉弘文, 大塚満雄
- Journal Title
  
  総合臨床
  
  Volume: 60(12) Pages: 2385-90
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] 特集特発性間質性肺炎-最近の進歩と展望. 病態と治療:特発性間質性肺炎の疫学2011
- Author(s)
  高橋弘毅、千葉弘文
- Journal Title
  
  最新医学
  
  Volume: 66(6) Pages: 1103-1107
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] Human surfactant protein A binds Mycoplasma pneumoniae by high affinity and attenuates its growth by recognition of disaturated-phosphatidylglycerols.2005
- Author(s)
  Pattanajitvilai S, Chiba H, et al.
- Journal Title
  
  J Biol Chem. 280(1)
  
  Pages: 9-17
- Data Source
  KAKENHI-PROJECT-15790414
[Journal Article] マイコプラズマ感染に対する自然免疫応答におけるサーファクタント蛋白質の役割2004
- Author(s)
  千葉弘文, 高橋弘毅, 阿部庄作
- Journal Title
  
  分子呼吸器病 8
  
  Pages: 54-56
- Data Source
  KAKENHI-PROJECT-15790414
[Journal Article] Surfactant protein A (SP-A) and toll like receptor 2 regulate the innate immune response to Mycoplasma Pneumonia.2003
- Author(s)
  Chiba H, Takahashi H, Shiratori M, Abe S
- Journal Title
  
  Airway Secrest Res. 5
  
  Pages: 35-46
- Data Source
  KAKENHI-PROJECT-15790414
[Presentation] 特発性肺線維症患者におけるモストグラフで測定した呼吸リアクタンスと生命予後との関連の検討．2023
- Author(s)
  石川立、森勇樹、錦織博貴、黒沼幸治、千葉弘文．
- Organizer
  第63回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K08570
[Presentation] 気管支鏡検査に関連したMycobacterium lentiflavumの偽アウトブレイク．2023
- Author(s)
  黒沼幸治、長野佑太郎、千葉弘文．
- Organizer
  第97回日本呼吸器内視鏡学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08570
[Presentation] 間質性肺疾患を有する難治性咳嗽に対してのP2X3受容体拮抗薬の有効性の検討．2023
- Author(s)
  髙橋知之、齋藤充史、萬谷峻史、池田貴美之、黒沼幸治、千葉弘文．
- Organizer
  第63回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K08570
[Presentation] COVID-19肺炎重症度予測マーカーとしてのIL-6, INF-l3, NGALの検討2022
- Author(s)
  齋藤充史、安田健人、黒沼幸治、中江舞美、藤谷好弘、高橋聡、千葉弘文
- Organizer
  第62回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K08570
[Presentation] Mycobacterium lentiflavumによるpseudo-outbreakの事例2022
- Author(s)
  黒沼幸治、長野佑太郎、千葉弘文
- Organizer
  第37回日本環境感染学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08570
[Presentation] リアルワールドデータ解析によるピルフェニドン誘発ペラグラ様光線過敏症の因子探索2022
- Author(s)
  黒沼幸治、小林智史、黒板智博、山本浩貴、須佐井菜摘、吉岡健、金子周司、千葉弘文
- Organizer
  第62回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K08570
[Presentation] マウスモデルにおけるペラグラ関連悪心に関するピルフェニドンの作用2022
- Author(s)
  小林智史、黒沼幸治、須佐井菜摘、黒板智博、吉岡健、千葉弘文
- Organizer
  第62回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K08570
[Presentation] The phosphate binder attenuates microlith formation and cox-2 induction in pulmonary alveolar microlithiasis.2021
- Author(s)
  Saito A, Takamiya R, Fujitani N, Ariki S, Kuronuma K, Chiba H.
- Organizer
  25th Congress of the APSR in Kyoto. 2021 Nov 19-20.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08570
[Presentation] COVID-19肺炎重症度予測マーカーとしての血清SP-A,D値の検討.2021
- Author(s)
  齋藤充史, 黒沼幸治, 小玉賢太郎, 茂庭慶悟, 高橋聡, 高橋弘毅, 千葉弘文.
- Organizer
  第61回日本呼吸器学会学術講演会2021年4月23-25日、東京
- Data Source
  KAKENHI-PROJECT-20K08570
[Presentation] ピルフェニドンの抗線維化作用におけるTRPV4の役割.2021
- Author(s)
  黒沼幸治, 大塚満雄, 若林雅人, 吉岡健, 小林智史, 亀田優美, 森岡靖英, 千葉弘文, 高橋弘毅.
- Organizer
  第61回日本呼吸器学会学術講演会2021年4月23-25日、東京
- Data Source
  KAKENHI-PROJECT-20K08570
[Presentation] Clinical significance of serum SP-D as a biomarker for antifibrotics in idiopathic pulmonary fibrosis (IPF): Post hoc analysis of a phase 3 trial of pirfenidone in Japan2019
- Author(s)
  Hirofumi Chiba
- Organizer
  European Respiratory Society Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08150
[Presentation] Significance of serum surfactant protein D for combined pulmonary fibrosis with emphysema in idiopathic pulmonary fibrosis2013
- Author(s)
  Yokoo K, Shiratori M, Natsuizaka M, Ikeda K,Otsuka M, Chiba H, Yamada G, Koba H,Takahashi H
- Organizer
  18th Congress of the Asian Pacific Society of Respirology
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] Difference in the dynamic state between SP-A and SP-D in the lung2013
- Author(s)
  Nishikiori H, Chiba H, Otsuka M, Ikeda K,Takahashi H
- Organizer
  23th European Respiratory Society Annual Congress
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] Subtypes of pulmonary emphysema on HRCT affect prognosis on combined pulmonary fibrosis and emphysema in idiopathic pulmonary fibrosis2013
- Author(s)
  Shiratori M, Yokoo K, Ikeda K, Natsuizaka M,Umeda Y, Kitamura Y, Otsuka M, Chiba H,Koba H, Takahashi H
- Organizer
  23th European Respiratory Society Annual Congress
- Place of Presentation
  Barcelona,Spain
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] Serum surfactant protein D may predict the effect of pirfenidone in idiopathic pulmonary fibrosis2013
- Author(s)
  Ikeda K, Shiratori S, Yokoo K, Otsuka M,Chiba H, Takahashi H
- Organizer
  23th European Respiratory Society Annual Congress
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] The decrease of surfactant protein D in bronchoalveolar lavage fluid in patients with idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia2013
- Author(s)
  Nishikiori H, Chiba H, Otsuka M, Kuronuma K, Takahashi H
- Organizer
  22th European Respiratory Society Annual Congress
- Place of Presentation
  Wien,Austria
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] Epidemiological survey of patients with idiopathic interstitial pneumonias using clinical personal records in Hokkaido, Japan2012
- Author(s)
  Natsuizaka M, Chiba H, Shiratori M, Mori M,Sugiyama Y, Takahashi H
- Organizer
  107th International Conference of American Thoracic Society
- Place of Presentation
  San Francisco, U.S.A.
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] Anionic surfactant phospholipids modulate Mycoplasma pneumoniae-Induced inflammatory response from alveolar macrophages and U937 Cells.2009
- Author(s)
  Kuronuma K, Chiba H, Takahshi H, Voelker D.
- Organizer
  In : The 19^<th> European Respiratory Society Annual Congress
- Place of Presentation
  Wien, Austria
- Data Source
  KAKENHI-PROJECT-20590930
[Presentation] Autoantibodies to the surfactant protein D in patientswith interstitial lung diseases associated with amyopathic dermatomyositis and systemic sclerosis.2008
- Author(s)
  Chiba H
- Organizer
  European Respiratory Society
- Place of Presentation
  ドイツベルリン
- Year and Date
  2008-10-06
- Data Source
  KAKENHI-PROJECT-20590930
[Presentation] Surfactant protein D in sera as a prognostic factor of idiopathic pulmonary fibrosis.2008
- Author(s)
  Shiratori M, Kanai A, Otsuka M, Chiba H, Takahashi H.
- Organizer
  In : The 103^<th> International Conference of American Thoracic Society
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-20590930
[Presentation] 特発性肺線維症におけるピルフェニドンの治療効果予測因子としての血清SP-D
- Author(s)
  千葉弘文、高橋弘毅ら
- Organizer
  日本肺サーファクタント・界面医学会学術研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] 特発性肺線維症における血清マーカーとピルフェニドンの治療効果との関連についての検討
- Author(s)
  池田貴美之, 白鳥正典, 横尾慶紀, 黒沼幸治, 大塚満雄, 千葉弘文, 高橋弘毅
- Organizer
  第111回日本内科学会講演会
- Place of Presentation
  東京国際フォーラム(東京都千代田区)
- Year and Date
  2014-04-11 – 2014-04-13
- Data Source
  KAKENHI-PROJECT-26461164
[Presentation] 特発性肺線維症におけるピルフェニドンの治療効果予測因子としての血清SP-D
- Author(s)
  池田貴美之, 白鳥正典, 横尾慶紀, 梅田泰淳, 汐谷心, 錦織博貴, 黒沼幸治, 大塚満雄, 千葉弘文, 高橋弘毅
- Organizer
  第54回日本呼吸器学会学術講演会
- Place of Presentation
  大阪国際会議場（大阪）
- Year and Date
  2014-04-25 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-26461164

1. TAKAHASHI Hiroki (60231396)

# of Collaborated Projects: 6 results

# of Collaborated Products: 32 results
2. KURONUMA Koji (40563250)

# of Collaborated Projects: 6 results

# of Collaborated Products: 30 results
3. KUROKI Yoshio (70161784)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. SAITO ATSUSHI (00768939)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
5. SHIRATORI Masanori (40295366)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
6. KUDO Kazumi (90438002)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 大塚満雄 (10398323)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
8. 高橋素子 (00303941)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
9. YAMADA Gen (70315505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SANO Hitomi (80295344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NISHITANI Chiaki (30381255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HASEGAWA YOSHIHIRO (90643180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 四十坊典晴 (70231355)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YOKOTA Shin-ichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 佐藤豊孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 齋藤淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

CHIBA HIROFUMI 千葉 弘文

Chiba Hirofumi 千葉 弘文

CHIBA Hirofumi 千葉 弘文

Research Projects

Research Products

Co-Researchers

自然免疫機構に着目した肺線維化病態の探索Principal Investigator

Principal Investigator

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Review Section

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肺マイクロバイオームの変容と自然免疫応答異常に注目したIPF病態の解明Principal Investigator

Principal Investigator

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Review Section

Research Institution

Loss of lung microbiome diversity and immune mechanisms of pulmonary surfactant proteins

Principal Investigator

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Review Section

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Elucidation of the pathophysiology of acute exacerbation of IPF based on lung microbiome analysis and development of innovative treatment strategiesPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Pulmonary fibrosis treatment with pulmonary surfactant as a TLR regulatory molecule and HSP47 inhibition

Principal Investigator

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Suppression of pulmonary injury and fibrosis by applying new action of pulmonary surfactant protein

Principal Investigator

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Therapeutic application of lung collectin in acute lung injury

Principal Investigator

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Pulmonary collectin regulates drug-induced lung injury.

Principal Investigator

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Mechanisms of innate immune surveillance by pulmonary surfactant proteins and their clinical application to respiratory infection.

Principal Investigator

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気管支喘息の増悪因子としてのマイコプラズマ感染とTLRの関与Principal Investigator

Principal Investigator

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Regulation of TLR by surfactant proteins in interstitial pneumonia

Principal Investigator

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Investigation of induction of Th1 cytokines by osteopontin in granulomatous lung diseasesPrincipal Investigator

Principal Investigator

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Research Institution

[Book] インフォームドコンセントのための図解シリーズ びまん性肺疾患と特発性肺炎．2014

Author(s)

CHIBA HIROFUMI 千葉弘文

Chiba Hirofumi 千葉弘文

CHIBA Hirofumi 千葉弘文

[Book] インフォームドコンセントのための図解シリーズ　びまん性肺疾患と特発性肺炎．2014

[Book] 総論治療1.生活習慣と薬物療法.監修.インフォームドコンセントのための図解シリーズびまん性肺疾患と特発性肺炎2014

[Book] Annual Rewiew 呼吸器2010(III. 診断の進歩:3.肺線維症におけるバイオマーカーの最近の知見)(永井厚志他編)東京2010