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Yasui Fumihiko  安井 文彦

… Alternative Names

YASUI Fumihiko  安井 文彦

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Researcher Number 40399473
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-3757-2569
Affiliation (Current) 2025: 公益財団法人東京都医学総合研究所, 感染症医学研究センター, ユニットリーダー
2025: 公益財団法人東京都医学総合研究所, 疾患制御研究分野, プロジェクトリーダー
Affiliation (based on the past Project Information) *help 2025: 公益財団法人東京都医学総合研究所, 感染症医学研究センター, ユニットリーダー
2022 – 2023: 公益財団法人東京都医学総合研究所, 疾患制御研究分野, プロジェクトリーダー
2017 – 2022: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, プロジェクトリーダー
2020: 公益財団法人東京都医学総合研究所, 疾患制御研究分野, プロジェクトリーダー
2015: 公益財団財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主席研究員 … More
2012 – 2015: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主席研究員
2014: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, プロジェクトリーダー
2010: (財)東京都医学総合研究所, 東京都臨床医学総合研究所, 主任研究員
2010: 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 主任研究員
2007 – 2010: The Tokyo Metropolitan Institute of Medical Science., Tokyo Metropolitan Organization for Medical Research, Researcher
2009: Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 主任研究員
2007: 東京都臨床医学総合研究所, 研究員
2005 – 2006: (財)東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 Less
Review Section/Research Field
Principal Investigator
Basic Section 49030:Experimental pathology-related / Experimental pathology / Virology
Except Principal Investigator
Virology / Biological Sciences / Medium-sized Section 58:Society medicine, nursing, and related fields / Cell biology
Keywords
Principal Investigator
COVID-19 / 重症肺炎 / 低応答性 / 高病原性 / 重症化モデルマウス / 野生型マウス / 重症化別 / ベータ株 / 肺線維症 / 宿主因子 … More / 加齢 / 感染症 / 宿主免疫 / ワクチン / 重症化 / B細胞濾胞 / 高病原性鳥インフルエンザ / 液性免疫 / 抗体 / 肺炎 / 免疫応答 / 個体 … More
Except Principal Investigator
C型肝炎ウイルス / 宿主因子 / HA蛋白質 / インフルエンザウイルス / 特殊環状ペプチド / 持続感染 / 宿主転写因子 / 潜伏感染 / 単純ヘルペスウイルス1型 / 再活性化 / 回帰発症 / 単純ヘルペスウイルス / Host factor / HCV replicon / Lipid raft / Replication / Hepatitis C Virus / HCVレプリコン / 脂質ラフト / 遺伝子複製 / 増殖阻害 / パントロピック / 抗ウイルス剤 / 感染阻害 / インフルエンザ / 脂肪変性 / C型肝炎ウイルス / 免疫学 / ウイルス排除 / 宿主免疫応答 / 持続感染化 / ウイルス増殖阻害 / 低分子ペプチド / 抗体医薬 / 治療効果 / 中和活性 / HAタンパク質 / ワクチン / 感染防御 / 間発がん / 慢性炎症 / 免疫応答 / スファンゴ脂質 / セラミド / スフィンゴミエリン分子種 / スフィンゴ脂質 / 分子・生体膜 / トランスジェニックマウス / 獲得免疫 / 自然免疫 / p53蛋白質 / WRN蛋白質 / 持続感染複製 / 肝がん Less
  • Research Projects

    (14 results)
  • Research Products

    (79 results)
  • Co-Researchers

    (21 People)
  •  致死性COVID-19老齢マウスモデルの重症化因子の同定とその制御法の確立Principal Investigator

    • Principal Investigator
      安井 文彦
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Exploration of factors contributing to disease severity using COVID-19 mouse models with different severity.Principal Investigator

    • Principal Investigator
      安井 文彦
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Development of recurrence prevention method for herpes simplex virus infection

    • Principal Investigator
      Takano Takashi
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 58:Society medicine, nursing, and related fields
    • Research Institution
      Nippon Veterinary and Life Science University
  •  Analysis of the mechanism of influenza severity caused by hyporesponsiveness of humoral immune responsesPrincipal Investigator

    • Principal Investigator
      YASUI Fumihiko
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  高病原性鳥インフルエンザウイルス感染に対する宿主免疫低応答性機序の解析Principal Investigator

    • Principal Investigator
      安井 文彦
    • Project Period (FY)
      2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Influenza viral hemagglutinin-targeted macrocyclic peptides as an antiviral agent

    • Principal Investigator
      KOHARA Michinori
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Virology
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Tissue macrophages are responsible for inflammatory liver disease in the hepatitis C virus transgenic mice

    • Principal Investigator
      KOHARA Michinori
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Influenza viral hemagglutinin-targeted macrocycles as an antiviral agent

    • Principal Investigator
      KOHARA Michinori
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Virology
    • Research Institution
      公益財団法人東京都医学総合研究所
      Tokyo Metropolitan Organization for Medical Research
  •  免疫系の攪乱によるC型肝炎ウイルスの持続感染化及び発症機序の解析とその制御

    • Principal Investigator
      小原 道法
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Analysis of mechanisms underlying the development of severe acute respiratory syndromePrincipal Investigator

    • Principal Investigator
      YASUI Fumihiko
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Virology
    • Research Institution
      財団法人東京都医学研究機構
      Tokyo Metropolitan Organization for Medical Research
  •  The role of sphingolipids in hepatitis C virus replication and its alteration of spingolipids metabolism.

    • Principal Investigator
      HIRATA Yuichi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
    • Research Field
      Cell biology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Persistent infection of Hepatitis C virus to get over the acquired immunity system

    • Principal Investigator
      KOHARA Michinori
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  24-dehydrocholesterol reductase(DHCR24) inhibitor suppresses HCV replication

    • Principal Investigator
      KOHARA Michinori
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  C型肝炎ウイルスによる遺伝子変異蓄積及び細胞不死化機序の解析

    • Principal Investigator
      KOHARA Michinori
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research

All 2022 2019 2018 2017 2014 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Patent

  • [Journal Article] In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus2014

    • Author(s)
      Watanabe T, Hatakeyama H, Matsuda-Yasui C, Sato Y, Sudoh M, Takagi A, Hirata Y, Ohtsuki T, Arai M, Inoue K, Harashima H, Kohara M
    • Journal Title

      Scientific Reports

      Volume: in press Issue: 1 Pages: 4750-4750

    • DOI

      10.1038/srep04750

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-24107502, KAKENHI-PROJECT-24390117, KAKENHI-PROJECT-24590988, KAKENHI-PUBLICLY-25114712, KAKENHI-PROJECT-25860305, KAKENHI-PROJECT-26893001
  • [Journal Article] Phagocytic cells contribute to the antibody-mediated elimination of pulmonary-infected SARS coronavirus.2014

    • Author(s)
      Yasui F, Kohara M, Kitabatake M, Nishiwaki T, Fujii H, Tateno C, Yoneda M, Morita K, Matsushima K, Koyasu S, Kai C
    • Journal Title

      Virology

      Volume: 454-455 Pages: 157-168

    • DOI

      10.1016/j.virol.2014.02.005

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22229004, KAKENHI-PROJECT-25670224, KAKENHI-PROJECT-25670235, KAKENHI-PROJECT-25860813, KAKENHI-PROJECT-22228005
  • [Journal Article] Histopathological evaluation of the diversity of cells susceptible to H5N1 virulent avian influenza virus2013

    • Author(s)
      Ogiwara H, Yasui F, Munekata K, Takagi-Kamiya A, Munakata T, Nomura N, Shibasaki F, Kuwahara K, Sakaguchi N, Sakoda Y, Kida H, Kohara M
    • Journal Title

      Am. J. Pathol

      Volume: 184 Issue: 1 Pages: 171-183

    • DOI

      10.1016/j.ajpath.2013.10.004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23390122, KAKENHI-PROJECT-23659314, KAKENHI-PROJECT-24590388, KAKENHI-PROJECT-24590565, KAKENHI-PROJECT-24659224, KAKENHI-PROJECT-25670224, KAKENHI-PROJECT-25670281
  • [Journal Article] Experimental Infection of Macaques with a Wild Water Bird-Derived Highly Pathogenic Avian Influenza Virus (H5N1).2013

    • Author(s)
      Fujiyuki, T., Yoneda, M., Yasui, F., Kuraishi, T., Hattori, S., Kwon, HJ., Munekata, K., Kiso, Y., Kida, H., Kohara, M., Kai, C.
    • Journal Title

      PLoS One

      Volume: 18;8(12) Issue: 12 Pages: e83551-e83551

    • DOI

      10.1371/journal.pone.0083551

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22228005, KAKENHI-PROJECT-25670224
  • [Journal Article] Synthetic lipophilic antioxidant BO-653 suppresses HCV replication2013

    • Author(s)
      Fumihiko Yasui, Masayuki Sudoh, Masaaki Arai, Michinori Kohara
    • Journal Title

      J. Med. Virol. J. Med. Virol

      Volume: 85(2) Pages: 241-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659238
  • [Journal Article] PA from an H5N1 highly pathogenic avian influenza virus activates viral transcription and replication, and induces apoptosis and interferon expression2012

    • Author(s)
      Qiang Wang, Shijian Zhang, Hongbing Jiang, Jinalan Wang, Leiyun, Weng, Yingying Mao, Satoshi Sekiguchi, Fumihiko Yasui, Michinori Kohara, Philippe Buchy, Vincent Deubel, Ke Xu, Bing Sun and Tetsuya Toyoda
    • Journal Title

      Virology Journal

      Volume: 8;9 Pages: 106-118

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659238
  • [Journal Article] Synthetic lipophilic antioxidant BO-653 suppresses HCV replication.2012

    • Author(s)
      Yasui F.
    • Journal Title

      J. Medical Virology

      Volume: 85 Issue: 2 Pages: 241-249

    • DOI

      10.1002/jmv.23466

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659238, KAKENHI-PROJECT-24390117, KAKENHI-PUBLICLY-25114712, KAKENHI-PUBLICLY-23114511
  • [Journal Article] Immunization with a recombinant vaccinia virus that encodes nonstructural proteins of the hepatitis C virus suppresses viral protein levels in mouse liver2012

    • Author(s)
      Satoshi Sekiguchi, Kiminori Kimura, Tomoko Chiyo, Takahiro Ohtsuki, Yoshimi Tobita, Yuko Tokunaga, Fumihiko Yasui, Kyoko Tsukiyama-Kohara, Takaji Wakita, Toshiyuki Tanaka, Masayuki Miyasaka, Kyosuke Mizuno, Yukiko Hayashi, Tsunekazu Hishima, Kouji Matsushima and Michinori Kohara
    • Journal Title

      PLoS ONE

      Volume: 7(12)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659238
  • [Journal Article] Analysis of the mechanism by which BALB/c mice having priorimmunization with nucleocapsid protein of SARS-CoV develop severepneumonia after SARS-CoV infection2010

    • Author(s)
      Fumihiko Yasui
    • Journal Title

      Procedia in Vaccinology (印刷中)

    • Data Source
      KAKENHI-PROJECT-21790455
  • [Journal Article] Identification of SARS-CoV spike protein-derived and HLA-A2-restricted human CTL epitope by using a new muramyl dipeptide- derivative adjuvant.2010

    • Author(s)
      Chen Y-Z, Liu G, Senju S, Wang Q, Irie A, Haruta M, Matsui M, Yasui F, Kohara M, Nishimura Y.
    • Journal Title

      International Journal of Immunopathology and Pharmacology 23

      Pages: 165-177

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790455
  • [Journal Article] SARSワクチン2009

    • Author(s)
      安井文彦、小原道法
    • Journal Title

      化学療法の領域 25

      Pages: 47-55

    • Data Source
      KAKENHI-PROJECT-21790455
  • [Journal Article] SARSワクチン2009

    • Author(s)
      安井文彦、小原道法
    • Journal Title

      医薬ジャーナル社・化学療法の領域 25

      Pages: 47-55

    • Data Source
      KAKENHI-PROJECT-21790455
  • [Journal Article] Prior immunization with SARS-CoV nucleocapsid protein causes severe pneumonia in mice infected with SARS-CoV.2008

    • Author(s)
      Yasui F.
    • Journal Title

      J. Immunology 181(9)

      Pages: 6337-48

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19041077
  • [Journal Article] Prior immunization with SARS-CoV nucleocapsid protein causes severe pneumonia in mice infected with SARS-CoV2008

    • Author(s)
      Fumihiko Yasui, Chieko Kai, Masahiro Kitabatake, Shingo Inoue, Misako Yoneda, Shoji Yokochi, Ryoichi Kase, Satoshi Sekiguchi, Kouichi Morita, Tsunekazu Hishima, Hidenori Suzuki, Katsuo Karamatsu, Yasuhiro Yasutomi, Hisatoshi Shida, Minoru Kidokoro, Kyosuke Mizuno, Kouji Matsushima, Michinori Kohara
    • Journal Title

      J. Immunology 181(9)

      Pages: 6337-48

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19041077
  • [Journal Article] Evaluation of a Cyclophilin Inhibitor in Hepatitis C Virus-Infected Chimeric Mice In Vivo.2007

    • Author(s)
      Kazuaki Inoue, Takuya Umehara, Urs T. Ruegg, Fumihiko Yasui, Tsunamasa Watanabe, Hiroshi Yasuda, Makoto Yoshiba, Jean-Maurice Dumont, Pietro Scalfaro, Michinori Kohara.
    • Journal Title

      Hepatology 45

      Pages: 921-928

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390146
  • [Journal Article] Liver target delivery of small interfering RNA to the HCV gene by lactosylated cationic liposome.2007

    • Author(s)
      Tsunamasa Watanabe, Takuya Umehara, Fumihiko Yasui, Shin-ichiro Nakagawa, Junichi Yano, Tadaaki Ohgi, Satoru Sonoke, Kazuaki Inoue, Makoto Yoshiba and Michinori Kohara.
    • Journal Title

      J. Hepatology 47

      Pages: 744-750

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390146
  • [Journal Article] SARS-CoV spike protein recombinant vaccinia virus efficiently induces neutralizing antibodies in spite of pre-immunization with vaccinia virus.2007

    • Author(s)
      Masahiro Kitabatake, Shingo Inoue, Fumihiko Yasui, Shoji Yokochi, Masaaki Arai, Kouichi Morita, Hisatoshi Shida, Minoru Kidokoro, Fukashi Murai, Mai Quynh Le, Kouji Matsushima and Michinori Kohara.
    • Journal Title

      Vaccine 25

      Pages: 630-637

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390146
  • [Journal Article] SARS-CoV spike protein recombinant vaccinia virus efficiently induces neutralizing antibodies in spite of pre-immunization with vaccinia virus2007

    • Author(s)
      Masahiro Kitabatake, Shingo Inoue, Fumihiko Yasui, Shoji Yokochi, Masaaki Arai, Kouichi Morita, Hisatoshi Shida, Minoru Kidokoro, Fukashi Murai, Mai Quynh Le, Kouji Matsushima and Michinori Kohara
    • Journal Title

      Vaccine 25

      Pages: 630-637

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19041077
  • [Journal Article] Liver target delivery of small interfering RNA to the HCV gene by lactosylated cationic liposome2007

    • Author(s)
      Tsunamasa Watanabe, Takuya Umehara, Fumihiko Yasui, Shin-ichiro Nakagawa, Junichi Yano, Tadaaki Ohgi, Satoru Sonoke, Kazuaki Inoue, Makoto Yoshiba and Michinori Kohara
    • Journal Title

      J. Hepatology 47

      Pages: 744-750

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19041077
  • [Journal Article] Evaluation of a Cyclophilin Inhibitor in Hepatitis C Virus-Infected Chimeric Mice In Vivo2007

    • Author(s)
      Kazuaki Inoue, Takuya Umehara, Urs T. Ruegg, Fumihiko Yasui, Tsunamasa Watanabe, Hiroshi Yasuda, Makoto Yoshiba, Jean-Maurice Dumont, Pietro Scalfaro, Michinori Kohara
    • Journal Title

      Hepatology 45

      Pages: 921-928

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19041077
  • [Journal Article] Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model.2006

    • Author(s)
      Takuya Umehara, Masayuki Sudoh, Fumihiko Yasui, Chiho Matsuda, Yukiko Hayashi, and Michinori Kohara.
    • Journal Title

      Biochem. Biophys. Res. Commun. 346

      Pages: 67-73

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390146
  • [Patent] 抗C型肝炎ウイルス効果を有するベンゾフラン誘導体2009

    • Inventor(s)
      小原道法、安井文彦、須藤正幸
    • Industrial Property Rights Holder
      財団法人東京都医学研究機構、中外製薬株式会社
    • Industrial Property Number
      2009-093608
    • Filing Date
      2009-04-08
    • Data Source
      KAKENHI-PUBLICLY-21022054
  • [Presentation] Infectivity and pathogenicity of SARS-CoV-2 beta variant in wild-type mice2022

    • Author(s)
      Fumihiko Yasui, Yusuke Matsumoto, Naoki Yamamoto, Takahiro Sanada, Tomoko Honda, Tsubasa Munakata, Yasushi Itoh, Michinori Kohara
    • Organizer
      第69回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K07038
  • [Presentation] 即時性及び長期持続性免疫誘導能を有する組換えインフルエンザワクチンによる発症防御効果の検討2019

    • Author(s)
      安井文彦、山地賢三郎、本田智子、倉石武、藤幸知子、伊藤靖、米田美佐子、迫田義博、小笠原一誠、服部正策、喜田宏、甲斐知恵子、小原道法
    • Organizer
      第23回日本ワクチン学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K08801
  • [Presentation] カニクイザルでのH7N9 鳥インフルエンザHAタンパク質発現組換えワクシニアワクチンの発症防御効果の検討2018

    • Author(s)
      山地賢三郎、安井文彦、伊藤靖、鈴木紗織、本田智子、山本直樹、真田崇弘、石垣宏仁、石井孝司、小笠原一誠、小原道法
    • Organizer
      第22回日本ワクチン学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K08801
  • [Presentation] Evaluation of vaccine potential of recombinant vaccinia virus encoding H5 subtype hemagglutinin against H5N1 influenza viruses2018

    • Author(s)
      Fumihiko Yasui, Keisuke Munekata, Tomoko Fujiyuki, Takeshi Kuraishi, Tomoko Honda, Yoshihiro Sakoda, Misako Yoneda, Hiroshi Kida, Shosaku Hattori, Chieko Kai, Michinori Kohara
    • Organizer
      12th Vaccine Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08801
  • [Presentation] Protective effect of a recombinant influenza vaccine against H5 subtype viruses based on highly attenuated vaccinia virus vector2018

    • Author(s)
      Fumihiko Yasui, Keisuke Munekata, Tomoko Honda, Yasushi Itoh, Yoshihiro Sakoda, Nobuo Sakaguchi, Hiroshi Kida, Kazumasa Ogasawara, Michinori Kohara
    • Organizer
      12th China-Japan Virology Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08801
  • [Presentation] 弱毒化ワクシニアウイルスDIs株を母体とした組換えH5亜型HAインフルエンザワクチン-による発症防御機序の解析2017

    • Author(s)
      安井 文彦
    • Organizer
      第21回日本ワクチン学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K08801
  • [Presentation] Single immunization with H5N1 influenza vaccine based on recombinant vaccinia virus protects mice and macaques from challenge with H5N1 in fluenza virus2012

    • Author(s)
      Yasui F.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-07
    • Data Source
      KAKENHI-PROJECT-24390117
  • [Presentation] Single immunization with H5N1 influenza vaccine based on recombinant vaccinia virus protects mice and macaques from challenge with H5N1 influenza virus2012

    • Author(s)
      Yasui F., Munekata K., Itoh Y., Sakoda Y., Kida H., Ogasawara K., Kohara M
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国
    • Data Source
      KAKENHI-PROJECT-23659238
  • [Presentation] カニクイザルモデルでのH5N1高病原性トリインフルエンザ組換えワクシニアワクチン単回接種による発症防御効果の検討2012

    • Author(s)
      安井 文彦
    • Organizer
      第16回日本ワクチン学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2012-11-17
    • Data Source
      KAKENHI-PROJECT-24390117
  • [Presentation] Development of recombinant H5N1 influenza vaccine based on vaccinia virus vector2012

    • Author(s)
      Yasui F.
    • Organizer
      6^<th> Vaccine & ISV Congress
    • Place of Presentation
      Shanghai(China)
    • Year and Date
      2012-10-15
    • Data Source
      KAKENHI-PROJECT-24390117
  • [Presentation] Development of recombinant H5N1 influenza vaccine based on vaccinia virus vector2012

    • Author(s)
      Yasui F., Sakoda Y., Kida H., Itoh Y., Ogasawara K., Kohara M
    • Organizer
      6^<th> Vaccine & ISV Congress
    • Place of Presentation
      Shanghai(China)
    • Data Source
      KAKENHI-PROJECT-23659238
  • [Presentation] Development of Pandemic Influenza Vaccines based on Recombinant Vaccinia Virus2012

    • Author(s)
      Yasui F.
    • Organizer
      2012 TEPIK International Influenza Symposium
    • Place of Presentation
      Seoul(KOREA)(招待講演)
    • Year and Date
      2012-06-29
    • Data Source
      KAKENHI-PROJECT-24390117
  • [Presentation] Immunization with recombinant vaccinia virus expressing hemagglition protein of H5N1 HPAIV protect mice from lethal H5N1 HPIV infection via the nentralizing antibody-independent mechanism2011

    • Author(s)
      Yasui F. et al.
    • Organizer
      Keystone Symposia-Pathogenesis of Influenza
    • Place of Presentation
      Kowloon(Hong Kong)
    • Data Source
      KAKENHI-PROJECT-23659238
  • [Presentation] A single immunization with highly attenuated vaccinia virus DIs-based vaccines induce protective immunity against H5N1 avian influenza virus in mice2011

    • Author(s)
      Gomi S., Naganawa S., Yasui F., Munekata K., Ishii K., Sakoda Y., Kida H. Kohara M
    • Organizer
      International Union of Microbiological Societies(IUMS)2011
    • Place of Presentation
      Sapporo
    • Data Source
      KAKENHI-PROJECT-23659238
  • [Presentation] Clearance of SARS-CoV by cooperation of antibodies and phagocytes2011

    • Author(s)
      Yasui F., Kai C., Morita K., Kohara M
    • Organizer
      International Union of Microbiological Societies(IUMS)2011
    • Place of Presentation
      Sapporo
    • Data Source
      KAKENHI-PROJECT-23659238
  • [Presentation] Clearance of SARS-CoV by cooperation of antibodies and phagocytes2011

    • Author(s)
      Yasui F.et al.
    • Organizer
      International Union of Microbiological Societies
    • Place of Presentation
      Sapporo Convention Centar
    • Data Source
      KAKENHI-PROJECT-23659238
  • [Presentation] Immunization with recombinant vaccinia virus expressing hemagglition protein of H5N1 HPAIV protect mice from lethal H5N1 HPIV infection via the nentralizing antibody-independent mechanism2011

    • Author(s)
      Yasui F., Munekata K., Sakoda Y., Kida H., Shibata S., Murakami T., Kohara M
    • Organizer
      Keystone Symposia-Pathogenesis of Influenza
    • Place of Presentation
      Kowloon (Hong Kong)
    • Data Source
      KAKENHI-PROJECT-23659238
  • [Presentation] H5N1高病原性鳥インフルエンザウイルスHA発現組換えワクシニアウイルスワクチンによる発症防御機序の解析2011

    • Author(s)
      宗片圭祐、安井文彦、迫田義博、喜田 宏、柴田伸一、村上利夫、小原道法
    • Organizer
      第15回日本ワクチン学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23659238
  • [Presentation] Synthetic lipophilic antioxidant B0-653 suppresses HCV replication.2010

    • Author(s)
      Yasui F.
    • Organizer
      17^<th> International Meeting on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2010-09-13
    • Data Source
      KAKENHI-PUBLICLY-21022054
  • [Presentation] Synthetic lipophilic antioxidant BO-653 suppresses HCV replication.2010

    • Author(s)
      Yasui F., Sudoh M., Kohara M.
    • Organizer
      17th International Meeting on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-20200067
  • [Presentation] Prior immunization with SARS-CoV nucleocapsid protein causes severe pneumonia in mice infected with SARS-CoV2010

    • Author(s)
      Fumihiko Yasui
    • Organizer
      Keystone symposia (Immunological mechanism of vaccination)
    • Place of Presentation
      アメリカ・シアトル(Sheraton Seattle Hotel)
    • Year and Date
      2010-10-30
    • Data Source
      KAKENHI-PROJECT-21790455
  • [Presentation] 細胞障害性T細胞を介さない貧食細胞-抗体相互作用による肺組織中SARSコロナウイルスの排除2010

    • Author(s)
      安井文彦(代表)
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島
    • Data Source
      KAKENHI-PROJECT-21790455
  • [Presentation] Prior immunization with nucleocapsid protein of SARS-CoV aggravates pneumonia in mice after SARS-CoV infection.2010

    • Author(s)
      安井文彦(代表)
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology
    • Place of Presentation
      Seattle, WA USA
    • Data Source
      KAKENHI-PROJECT-21790455
  • [Presentation] インフルエンザウイルスHA遺伝子発現組換えワクチニアウイルスの感染防御効果の検討2010

    • Author(s)
      安井文彦(代表)
    • Organizer
      第14回日本ワクチン学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21790455
  • [Presentation] Analysis of the mechanism by which BALB/c mice having prior immuni zation with nucleocapsid protein of SARS-CoV develop severe pneumoni a after SARS-CoV infection.2009

    • Author(s)
      Fumihiko Yasui
    • Organizer
      3^<rd> Global Vaccine Congress
    • Place of Presentation
      The Ritz-Carlton, Millenia Singapore
    • Year and Date
      2009-10-04
    • Data Source
      KAKENHI-PROJECT-21790455
  • [Presentation] Analysis of the mechanism by which BALB/c mice having prior immunization with nucleocapsid protein of SARS-CoV developsevere pneumonia after SARS-CoV infection.2009

    • Author(s)
      Yasui F.
    • Organizer
      3^<rd> Global Vaccine Congress
    • Place of Presentation
      Singapore、シンガポール
    • Year and Date
      2009-10-04
    • Data Source
      KAKENHI-PUBLICLY-21022054
  • [Presentation] SARS-CoVのヌクレオキャプシドタンパク質を前免疫したマウスへのSRAS-CoV感染により惹起される肺炎重症化機序の解析2009

    • Author(s)
      安井文彦(代表)
    • Organizer
      第13回日本ワクチン学会
    • Place of Presentation
      札幌
    • Year and Date
      2009-09-27
    • Data Source
      KAKENHI-PROJECT-21790455
  • [Presentation] SARS-CoVのヌクレオキャプシドタンパク質を前免疫したマウスへのSRAS-CoV感染により惹起される肺炎重症化機序の解析2009

    • Author(s)
      安井文彦
    • Organizer
      第13回日本ワクチン学会
    • Place of Presentation
      札幌
    • Year and Date
      2009-09-27
    • Data Source
      KAKENHI-PUBLICLY-21022054
  • [Presentation] SARS-CoVのヌクレオキャップシドタンパク質を前免疫したマウスへのSARS-CoV感染により惹起される肺炎重症化機序の解析2009

    • Author(s)
      安井文彦(代表)
    • Organizer
      第4回中国バイオメディカルフォーラム
    • Place of Presentation
      大連
    • Data Source
      KAKENHI-PROJECT-21790455
  • [Presentation] SARS-CoVのヌクレオキャップシドタンパク質を前免疫したマウスへのSARS-CoV感染により惹起される肺炎重症化機序の解析2009

    • Author(s)
      安井文彦
    • Organizer
      第4回中国バイオメディカルフォーラム
    • Place of Presentation
      大連、中国
    • Data Source
      KAKENHI-PUBLICLY-21022054
  • [Presentation] Analysis of the mechanism by which BALB/c mice having prior immunization with nucleocapsid protein of SARS-CoV develop severe pneumonia after SARS-CoV infection.2009

    • Author(s)
      安井文彦(代表)
    • Organizer
      3rd Global Vaccine Congress
    • Place of Presentation
      Singapore
    • Data Source
      KAKENHI-PROJECT-21790455
  • [Presentation] SARS-CoVヌクレオキャプシドタンパク質を前免疫したマウスへのSARS-CoV感染により惹起される肺炎重症化機序の解析2009

    • Author(s)
      安井文彦
    • Organizer
      第13回日本ワクチン学会
    • Place of Presentation
      北海道・ロイトン札幌
    • Year and Date
      2009-09-27
    • Data Source
      KAKENHI-PROJECT-21790455
  • [Presentation] Serine Palmitoyltransferase Inhibitor Suppresses HCV Replication in a Mouse Model2008

    • Author(s)
      Hirata Y. Umehara T., Sudoh M., Yasui F., Kohara M
    • Organizer
      21th International Conference on Antiviral Research
    • Place of Presentation
      Montreal
    • Data Source
      KAKENHI-PROJECT-19041077
  • [Presentation] Serine Palmitoyltransferase Inhibitor Suppresses HCV Replication in a Mouse Model.2008

    • Author(s)
      Hirata Y. Umehara T., Sudoh M., Yasui F., Kohara M.
    • Organizer
      21th International Conference on Antiviral Research
    • Place of Presentation
      Montreal
    • Data Source
      KAKENHI-PROJECT-20200067
  • [Presentation] Prior immunization with SARS-CoVnucleocapsid protein causes severe pneumonia in mice infected with SARS-CoV2008

    • Author(s)
      Yasui F., Kai C., Kohara M.
    • Organizer
      XIV International Congress of Virology
    • Place of Presentation
      Istanbul
    • Data Source
      KAKENHI-PROJECT-19041077
  • [Presentation] Proteome analysis of HCV inhibitor from natural product, onjisaponin2008

    • Author(s)
      Sudoh M., Itoh T., Aoki M., Ohmori Y., Hirata Y., Yasui F., Kohara M., Aoki Y.
    • Organizer
      15th International Symposium on Hepatitis C Virus & Related Viruses
    • Place of Presentation
      Texas
    • Data Source
      KAKENHI-PROJECT-19041077
  • [Presentation] SRAS-CoVヌクレオキャプシドタンパク質の免疫によるSARS-CoV感染後の肺炎重篤化への関与2007

    • Author(s)
      安井文彦、甲斐知恵子、北畠正大、井上真吾、米田美佐子、森田公一、松島綱治、小原道法
    • Organizer
      SRAS-CoVヌクレオキャプシドタンパク質の免疫によるSARS-CoV感染後の肺炎重篤化への関与
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-19041077
  • [Presentation] Immunization of SARS-CoV nucleocapsid protein is involved in an aggravation of pulmonary inflammatory response to subsequent SARS-CoV infection.2007

    • Author(s)
      Yasui F.
    • Organizer
      第37回日本免疫学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390146
  • [Presentation] SRAS-CoVヌクレオキャプシドタンパク質の免疫によるSARS-CoV感染後の肺炎重篤化への関与.2007

    • Author(s)
      安井 文彦
    • Organizer
      第55回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390146
  • [Presentation] Pathogenesis of SARS-CoV infection in BALB/c mice pre-immunized with recombinant vaccinia virus expressing SARS-CoV structural proteins2007

    • Author(s)
      Yasui F., Kai C., Kitabatake M., Inoue S., Yoneda M., Yokochi S., Kase R., Morita K., Matsushima K., Sida K., Mizuno K., Kohara M.
    • Organizer
      第30回日本分子生物学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19041077
  • [Presentation] 免疫抑制作用のないサイクロスポリンA誘導体によるヒト肝臓キメラマウスにおけるHCV複製阻害2007

    • Author(s)
      井上和明、楳原琢哉、安井文彦、渡邊綱正、与芝真彰、小原道法
    • Organizer
      第55回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-19041077
  • [Presentation] SARS-CoV全構造タンパク質発現型RVV免疫マウスでのSARS-CoV感染後に起きる肺炎増悪の解析.2007

    • Author(s)
      安井 文彦
    • Organizer
      第11回日本ワクチン学会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390146
  • [Presentation] Immunization of SARS-CoV nucleocapsid protein is involved in anaggravation of pulmonary inflammatory response to subsequent SARS-CoVinfection2007

    • Author(s)
      Yasui F.
    • Organizer
      第37回日本免疫学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19041077
  • [Presentation] SARS-CoV全構造タンパク質発現型RVV免疫マウスでのSARS-CoV感染後に起きる肺炎増悪の解析2007

    • Author(s)
      安井文彦、甲斐知恵子、北畠正大、井上真吾、米田美佐子、横地祥司、加瀬良一、森田公一、松島綱治、志田壽利、水野喬介、小原道法
    • Organizer
      第11回日本ワクチン学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19041077
  • [Presentation] Immunizationof SARS-CoV nucleocapsid protein is involved in an aggravation of pulmonary inflammatory response to subsequent SARS-CoV infection2007

    • Author(s)
      Yasui F., Kai C., Kitabatake M., Inoue S., Morita K. Matsushima K., Kohara M
    • Organizer
      第37回日本免疫学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19041077
  • [Presentation] Pathogenesis of SARS-CoV infection in BALB/c mice pre-immunized with recombinant vaccinia virus expressing SARS-CoV structural proteins2007

    • Author(s)
      Yasui F.
    • Organizer
      第30回日本分子生物学会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390146
  • [Presentation] Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model.2006

    • Author(s)
      Umehara T., Sudoh M., Yasui F. and Kohara M.
    • Organizer
      13th International Meeting on Hepatitis C Virus &Related Viruses.
    • Place of Presentation
      Australia
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390146
  • [Presentation] Suppression of serine palmitoyltransferase inhibits HCV replication in mice with chimeric human liver.2006

    • Author(s)
      Umehara T., Sudoh M., Yasui F., Nakagawa S. and Kohara M.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390146
  • [Presentation] H5N1高病原性鳥インフルエンザウイルス感染に対する哺乳動物宿主の免疫低応答とインフルエンザ組換え生ワクチン接種による発症防御

    • Author(s)
      安井 文彦
    • Organizer
      第18回日本ワクチン学会学術集会
    • Place of Presentation
      福岡国際会議場 (福岡県福岡市)
    • Year and Date
      2014-12-06 – 2014-12-07
    • Data Source
      KAKENHI-PROJECT-26860271
  • [Presentation] 霊長類感染モデルを用いた高病原性鳥インフルエンザウイルス抗原発現組換え麻疹ウイルスの防御効果の解析

    • Author(s)
      藤幸知子、堀江 亮、米田美佐子、倉石 武、安井文彦、宗片圭祐、池田房子、基礎友里、権賢 貞、石井美穂、佐藤宏樹、服部正策、喜田 宏、小原道法、甲斐知恵
    • Organizer
      第61回日本実験動物学会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2014-05-15 – 2014-05-17
    • Data Source
      KAKENHI-PROJECT-25670224
  • [Presentation] Development of Pandemic Influenza Vaccines based on Recombinant Vaccinia Virus.

    • Author(s)
      Yasui F.
    • Organizer
      2012 TEPIK International Influenza Symposium
    • Place of Presentation
      Seoul (KOREA)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23659238
  • [Presentation] 亜型を超えた感染阻害活性を示すヘマグルチニン結合性特殊環状ペプチド

    • Author(s)
      斉藤 誠、安井文彦、棟方 翼、飛田良美、小澤 真、小原恭子、伊東利紗、菅 裕明、佐々木 亨、窪田規一、小原道法
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2014-11-10 – 2014-11-12
    • Data Source
      KAKENHI-PROJECT-25670224
  • [Presentation] Prophylatic effect of H5N1 influenza vaccine based on vaccinia virus vector in cynomolgus monkeys

    • Author(s)
      Fumihiko Yasui, Keisuke Munekata, Yasushi Itoh, Tomoko Fujiyuki, Takeshi Kuraishi, Yoshihiro Sakoda, Misako Yoneda, Hiroshi Kida, Shosaku Hattori, Chieko Kai, Kazumasa Ogasawara, Michinori Kohara
    • Organizer
      8th Vaccine & ISV Congress
    • Place of Presentation
      Philadelphia (USA)
    • Year and Date
      2014-10-26 – 2014-10-28
    • Data Source
      KAKENHI-PROJECT-25670224
  • [Presentation] Prophylatic effect of H5N1 influenza vaccine based on attenuated replicative vaccinia virus that contains endogenous adjuvant component

    • Author(s)
      Fumihiko Yasui, Keisuke Munekata, Yasushi Itoh, Tomoko Fujiyuki, Takeshi Kuraishi, Yoshihiro Sakoda, Misako Yoneda, Hiroshi Kida, Shosaku Hattori, Chieko Kai, Kazumasa Ogasawara, Michinori Kohara
    • Organizer
      KeystoneSymposia
    • Place of Presentation
      Seattle (USA)
    • Year and Date
      2014-10-08 – 2014-10-13
    • Data Source
      KAKENHI-PROJECT-25670224
  • [Presentation] Highly pathogenic avian influenza A H5N1 virus causes severe symptoms due to insufficient induction of humoral immune response

    • Author(s)
      Ai Ikejiri, Fumihiko Yasui, Yasushi Itoh, Masahiro Kitabatake, Nobuo Sakaguchi, Kazumasa Ogasawara, Michinori Kohara
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2014-12-10 – 2014-12-12
    • Data Source
      KAKENHI-PROJECT-25670224
  • [Presentation] H5N1高病原性鳥インフルエンザ組換えワクシニアワクチン単回接種による免疫長期持続作用機序の解析

    • Author(s)
      安井文彦、宗方圭祐、倉石 武、服部正策、藤幸知子、米田美佐子、迫田義博、喜田 宏、甲斐智恵子、小原道法
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2014-11-10 – 2014-11-12
    • Data Source
      KAKENHI-PROJECT-25670224
  • [Presentation] H5N1高病原性鳥インフルエンザウイルス感染に対する哺乳動物宿主の免疫応答とインフルエンザ組換え生ワクチン接種による発症防御

    • Author(s)
      安井文彦、伊藤 靖、池尻 藍、北畠正大、宗方圭祐、迫田義博、喜田 宏、坂口薫雄、小笠原一誠、小原道法
    • Organizer
      第18回日本ワクチン学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2014-12-06 – 2014-12-07
    • Data Source
      KAKENHI-PROJECT-25670224
  • 1.  KOHARA Michinori (10250218)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 36 results
  • 2.  MUNAKATA Tsubasa (50420237)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 1 results
  • 3.  SEKIGUCHI Satoshi (10462780)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 4.  HIRATA Yuichi (50439452)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 5.  MUNEKATA Keisuke (30569140)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 6.  YONEKAWA Hiromichi (30142110)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  HAYASHI Masahiro (70446566)
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  • 8.  TAKANO Takashi (20462781)
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  • 9.  NURIYA Hideko (80270685)
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  • 10.  TAGUCHI Ryo (20080210)
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  • 11.  SAITO Makoto (20433021)
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  • 12.  SUGA Hiroaki (00361668)
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  • 14.  習田 昌裕 (10356256)
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  • 15.  徳永 優子 (80555011)
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  • 18.  小安 重夫
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  • 19.  阪口 薫雄
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  • 21.  米田 美佐子
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