Furukawa Yoshiaki 古川良明

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FURUKAWA Yoshiaki 古川良明

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Researcher Number	40415287
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 理工学部(矢上), 教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 慶應義塾大学, 理工学部(矢上), 教授 2016 – 2019: 慶應義塾大学, 理工学部(矢上), 准教授 2010 – 2015: 慶應義塾大学, 理工学部, 准教授 2008 – 2009: The Institute of Physical and Chemical Research, 構造神経病理研究チーム, 基礎科学特別研究員 2007: The Institute of Physical and Chemical Research, 構造神経病理研究チーム, 基礎科学特別研究員 2006: 独立行政法人理化学研究所, 構造神経病理研究チーム, 研究員
Review Section/Research Field	Principal Investigator Functional biochemistry / Biological Sciences / Biophysics / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Transformative Research Areas, Section (III) / Medium-sized Section 47:Pharmaceutical sciences and related fields / Medium-sized Section 38:Agricultural chemistry and related fields / Complex systems / Science and Engineering Except Principal Investigator Complex systems
Keywords	Principal Investigator 神経変性疾患 / 金属タンパク質 / 筋萎縮性側索硬化症 / SOD1 / 蛋白質 / アミロイド / スーパーオキシドディスムターゼ / 銅シャペロン / 金属シャペロン / タンパク質 … More / 蛋白質凝集 / 銅タンパク質 / 銅イオン / 分子認識 / ミスフォールディング / ジスルフィド結合 / タンパク質凝集 / タンパク質ミスフォールディング / 金属シャペロンタンパク質 / タンパク質フォールディング / 凝集 / 蛋白質間分子認識 / 銅シャペロン蛋白質 / 金属シャペロン蛋白質 / 翻訳後修飾 / フォールディング / ApoE / アルツハイマー病 / ハンチントン病 / ポリグルタミン … More Except Principal Investigator 生体内金属動態 / 有害金属 / 生命金属 / 金属細胞生物学 / 生物無機化学 / 生命金属科学 Less

超硫黄化による銅シャペロン保護メカニズムの解明Principal Investigator
- Principal Investigator
  
  古川良明
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Keio University
神経変性疾患の早期診断を指向した構造異常型タンパク質の極微量検出Principal Investigator
- Principal Investigator
  
  古川良明
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Keio University
加齢に伴うタンパク質の構造・機能変化とその病理学的役割の解明Principal Investigator
- Principal Investigator
  
  古川良明
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Keio University
Detection of misfolded Cu/Zn-superoxide dismutase proteins with Caenorhabditis elegansPrincipal Investigator
- Principal Investigator
  
  Furukawa Yoshiaki
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Keio University
Integrated Biometal Science: Research to Explore Dynamics of Metals in Cellular System
- Principal Investigator
  
  Tsumoto Kouhei
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
生命金属動態を制御するシャペロン分子ネットワークの解明Principal Investigator
- Principal Investigator
  
  古川良明
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Keio University
分子夾雑環境におけるタンパク質の金属イオン獲得メカニズムPrincipal Investigator
- Principal Investigator
  
  古川良明
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Keio University
異常構造型脳タンパク質の経口摂取による神経変性疾患発症の可能性Principal Investigator
- Principal Investigator
  
  古川良明
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Understanding a mechanism regulating intracellular dynamics of metal ionsPrincipal Investigator
- Principal Investigator
  
  Furukawa Yoshiaki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Keio University
Identification of intracellular zinc chaperonesPrincipal Investigator
- Principal Investigator
  
  Furukawa Yoshiaki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Keio University
脳タンパク質老化の伝播性と感染性を検証する線虫モデルの確立Principal Investigator
- Principal Investigator
  
  古川良明
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
A mechanism regulating the copper acquisition by intracellular proteinsPrincipal Investigator
- Principal Investigator
  
  FURUKAWA YOSHIAKI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Keio University
シーディングによる脳内環境の破綻伝播メカニズムの解明Principal Investigator
- Principal Investigator
  
  古川良明
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
In vitro reconstitution of intracellular copper transport systemPrincipal Investigator
- Principal Investigator
  
  FURUKAWA YOSHIAKI
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Keio University
Molecular recognition of proteins regulating transport of copper ions in cellsPrincipal Investigator
- Principal Investigator
  
  FURUKAWA Yoshiaki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  Keio University
A molecular mechanism regulating pathological aggregation of SOD1 proteinsPrincipal Investigator
- Principal Investigator
  
  FURUKAWA Yoshiaki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  The Institute of Physical and Chemical Research
神経変性疾患に見られるアミロイド繊維の構造伝播メカニズムPrincipal Investigator
- Principal Investigator
  
  古川良明
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The Institute of Physical and Chemical Research
ApoE蛋白質が制御するアミロイド線維の形成と除去の分子メカニズムPrincipal Investigator
- Principal Investigator
  
  古川良明
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  The Institute of Physical and Chemical Research

[Book] 脳内環境辞典2017
- Author(s)
  古川　良明
- Total Pages
  156
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-16H04768
[Book] Bio-Nanoimaging: Insights into Protein Misfolding and Aggregation2014
- Author(s)
  Yoshiaki Furukawa
- Total Pages
  10
- Publisher
  Elsevier
- Data Source
  KAKENHI-PUBLICLY-24111542
[Book] "Polymorphism of Tau fibrils"In Bio-Nanoimaging : Insights into Protein Misfolding and Aggregation2014
- Author(s)
  Yoshiaki Furukawa(Uversky, V. and Lyubchenko, Y. Eds)
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-24657093
[Book] 「筋萎縮性側索硬化症におけるタンパク質の線維化とシーディング現象」遺伝子医学MOOK26号脳内環境−恒常性維持機構の破綻と病気2014
- Author(s)
  古川良明(高橋良輔、漆谷真、山中宏二、樋口真人編集)
- Publisher
  (印刷中)
- Data Source
  KAKENHI-PROJECT-24657093
[Book] Bionanoimaging: Insights into Protein Misfolding and Aggregation2013
- Author(s)
  Yoshiaki Furukawa
- Publisher
  Elsevier
- Data Source
  KAKENHI-PUBLICLY-24111542
[Book] Protein aggregates in pathological inclusions of amyotrophic lateral sclerosis2012
- Author(s)
  Yoshiaki Furukawa
- Total Pages
  22
- Publisher
  Intech
- Data Source
  KAKENHI-PROJECT-22770162
[Book] Amyotrophic Lateral Sclerosis2012
- Author(s)
  Yoshiaki Furukawa
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-22770162
[Journal Article] Engineering a monobody specific to monomeric Cu/Zn‐superoxide dismutase associated with amyotrophic lateral sclerosis2024
- Author(s)
  Amesaka Hiroshi、Hara Mizuho、Sakai Yuki、Shintani Atsuko、Sue Kaori、Yamanaka Tomoyuki、Tanaka Shun‐ichi、Furukawa Yoshiaki
- Journal Title
  
  Protein Science
  
  Volume: 33 Issue: 4
- DOI
  10.1002/pro.4961
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19458, KAKENHI-PROJECT-22K19389, KAKENHI-PROJECT-21K05386, KAKENHI-PLANNED-19H05765, KAKENHI-PROJECT-23K24031, KAKENHI-PUBLICLY-23H04559
[Journal Article] 生命現象を駆動する生体内金属動態の理解と展開2024
- Author(s)
  神戸、古川編集
- Journal Title
  
  生体の科学
  
  Volume: 75
- Data Source
  KAKENHI-ORGANIZER-19H05760
[Journal Article] Zinc-mediated interaction of copper chaperones through their heavy-metal associated domains2023
- Author(s)
  Furukawa Yoshiaki、Matsumoto Kyoka、Nakagome Kenta、Shintani Atsuko、Sue Kaori
- Journal Title
  
  Journal of Trace Elements in Medicine and Biology
  
  Volume: 75 Pages: 127111-127111
- DOI
  10.1016/j.jtemb.2022.127111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19389, KAKENHI-PLANNED-19H05765
[Journal Article] Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy-linked E40K mutation2023
- Author(s)
  Hashimoto Kei、Watanabe Seiji、Akutsu Masato、Muraki Norifumi、Kamishina Hiroaki、Furukawa Yoshiaki、Yamanaka Koji
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 6 Pages: 104798-104798
- DOI
  10.1016/j.jbc.2023.104798
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0214, KAKENHI-PROJECT-23K05670, KAKENHI-PROJECT-23K06826, KAKENHI-PROJECT-22KJ1574, KAKENHI-PLANNED-19H05765, KAKENHI-PROJECT-23K24031, KAKENHI-PROJECT-22H00467
[Journal Article] Characterization of a novel cysteine-less Cu/Zn-superoxide dismutase in Paenibacillus lautus missing a conserved disulfide bond2023
- Author(s)
  Furukawa Yoshiaki、Shintani Atsuko、Narikiyo Shuhei、Sue Kaori、Akutsu Masato、Muraki Norifumi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 8 Pages: 105040-105040
- DOI
  10.1016/j.jbc.2023.105040
- Data Source
  KAKENHI-PROJECT-23K05670, KAKENHI-PLANNED-19H05765
[Journal Article] A rapid and simple electrochemical detection of the free drug concentration in human serum using boron-doped diamond electrodes2022
- Author(s)
  Moriyama Hideto、Ogata Genki、Nashimoto Haruma、Sawamura Seishiro、Furukawa Yoshiaki、Hibino Hiroshi、Kusuhara Hiroyuki、Einaga Yasuaki
- Journal Title
  
  The Analyst
  
  Volume: 147 Issue: 20 Pages: 4442-4449
- DOI
  10.1039/d2an01037b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19389, KAKENHI-PROJECT-21H03805, KAKENHI-PROJECT-20K16005, KAKENHI-PLANNED-19H05765
[Journal Article] Metal distribution in Cu/Zn-superoxide dismutase revealed by native mass spectrometry2022
- Author(s)
  Tajiri Michiko、Aoki Hiroto、Shintani Atsuko、Sue Kaori、Akashi Satoko、Furukawa Yoshiaki
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 183 Pages: 60-68
- DOI
  10.1016/j.freeradbiomed.2022.03.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19389, KAKENHI-PLANNED-19H05774, KAKENHI-PLANNED-19H05765
[Journal Article] A pathological link between dysregulated copper binding in Cu/Zn-superoxide dismutase and amyotrophic lateral sclerosis2022
- Author(s)
  Furukawa Yoshiaki
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 71 Issue: 2 Pages: 73-77
- DOI
  10.3164/jcbn.22-42
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19389, KAKENHI-PLANNED-19H05765
[Journal Article] Quantum-dot-labeled synuclein seed assay identifies drugs modulating the experimental prion-like transmission2022
- Author(s)
  Imamura Yukio、Okuzumi Ayami、Yoshinaga Saki、Hiyama Akiko、Furukawa Yoshiaki、Miyasaka Tomohiro、Hattori Nobutaka、Nukina Nobuyuki
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 1-15
- DOI
  10.1038/s42003-022-03590-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21587, KAKENHI-PROJECT-22K19389, KAKENHI-PROJECT-21H04820, KAKENHI-PROJECT-19K16928, KAKENHI-PLANNED-19H05765, KAKENHI-PROJECT-23K24207
[Journal Article] Novel oxindole compounds inhibit the aggregation of amyloidogenic proteins associated with neurodegenerative diseases2022
- Author(s)
  Kimura Shintaro、Kamishina Hiroaki、Hirata Yoko、Furuta Kyoji、Furukawa Yoshiaki、Yamato Osamu、Maeda Sadatoshi、Kamatari Yuji O.
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1866 Issue: 5 Pages: 130114-130114
- DOI
  10.1016/j.bbagen.2022.130114
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06410, KAKENHI-PLANNED-19H05765, KAKENHI-PROJECT-20K06390, KAKENHI-PROJECT-20H04285
[Journal Article] A dual role of cysteine residues in the maturation of prokaryotic Cu/Zn-superoxide dismutase2021
- Author(s)
  Furukawa Yoshiaki、Shintani Atsuko、Kokubo Teppei
- Journal Title
  
  Metallomics
  
  Volume: 13 Issue: 9
- DOI
  10.1093/mtomcs/mfab050
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19H05765
[Journal Article] Oxidative misfolding of Cu/Zn-superoxide dismutase triggered by non-canonical intramolecular disulfide formation2020
- Author(s)
  Anzai Itsuki、Tokuda Eiichi、Handa Sumika、Misawa Hidemi、Akiyama Shuji、Furukawa Yoshiaki
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 147 Pages: 187-199
- DOI
  10.1016/j.freeradbiomed.2019.12.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07128, KAKENHI-PUBLICLY-18H04564, KAKENHI-PLANNED-19H05765, KAKENHI-PROJECT-17H06165, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-18J12708
[Journal Article] Wild-type Cu/Zn-superoxide dismutase is misfolded in cerebrospinal fluid of sporadic amyotrophic lateral sclerosis2019
- Author(s)
  Tokuda Eiichi、Takei Yo-ichi、Ohara Shinji、Fujiwara Noriko、Hozumi Isao、Furukawa Yoshiaki
- Journal Title
  
  Molecular Neurodegeneration
  
  Volume: 14 Issue: 1 Pages: 42-42
- DOI
  10.1186/s13024-019-0341-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04564, KAKENHI-PLANNED-19H05765, KAKENHI-PLANNED-19H05767, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-17K19666
[Journal Article] Prion-like Properties of Misfolded Cu/Zn-superoxide Dismutase in Amyotrophic Lateral Sclerosis: Update and Perspectives2019
- Author(s)
  Tokuda Eiichi、Marklund Stefan L.、Furukawa Yoshiaki
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 139 Issue: 7 Pages: 1015-1019
- DOI
  10.1248/yakushi.18-00165-5
- NAID
  130007670812
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2019-07-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04564, KAKENHI-PLANNED-19H05765, KAKENHI-PROJECT-16H04768
[Journal Article] Sequence- and seed-structure-dependent polymorphic fibrils of alpha-synuclein2019
- Author(s)
  Tanaka Goki、Yamanaka Tomoyuki、Furukawa Yoshiaki、Kajimura Naoko、Mitsuoka Kaoru、Nukina Nobuyuki
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  
  Volume: 19 Issue: 6 Pages: 30065-1
- DOI
  10.1016/j.bbadis.2019.02.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17KT0131, KAKENHI-PUBLICLY-17H05705, KAKENHI-PROJECT-17H01564, KAKENHI-PROJECT-18H02723, KAKENHI-PROJECT-17J05799, KAKENHI-PROJECT-15K06762, KAKENHI-PUBLICLY-18H04564, KAKENHI-PLANNED-19H05765, KAKENHI-PROJECT-16H04768
[Journal Article] Biochemical and morphological classification of disease-associated alpha-synuclein mutants aggregates2019
- Author(s)
  Tanaka Goki、Yamanaka Tomoyuki、Furukawa Yoshiaki、Kajimura Naoko、Mitsuoka Kaoru、Nukina Nobuyuki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 508 Issue: 3 Pages: 729-734
- DOI
  10.1016/j.bbrc.2018.11.200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17KT0131, KAKENHI-PUBLICLY-17H05705, KAKENHI-PUBLICLY-18H04564, KAKENHI-PROJECT-17H01564, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-18H02723, KAKENHI-PROJECT-17J05799, KAKENHI-PROJECT-15K06762
[Journal Article] Identification of a novel zinc-binding protein, C1orf123, as an interactor with a heavy metal-associated domain2018
- Author(s)
  Furukawa Yoshiaki、Lim Carolyn、Tosha Takehiko、Yoshida Koki、Hagai Tomoaki、Akiyama Shuji、Watanabe Shoji、Nakagome Kenta、Shiro Yoshitsugu
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 9 Pages: e0204355-e0204355
- DOI
  10.1371/journal.pone.0204355
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05705, KAKENHI-PUBLICLY-18H04564, KAKENHI-PROJECT-17H06165, KAKENHI-PROJECT-26220807, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-17H03092
[Journal Article] Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals.2018
- Author(s)
  Tamaki Y, Shodai A, Morimura T, Hikiami R, Minamiyama S, Ayaki T, Tooyama I, Furukawa Y, Takahashi R, Urushitani M.
- Journal Title
  
  Scientific Reports
  
  Volume: 印刷中 Issue: 1 Pages: 6030-6030
- DOI
  10.1038/s41598-018-24463-3
- NAID
  120006482849
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08077, KAKENHI-PROJECT-26290023, KAKENHI-PUBLICLY-17H05705, KAKENHI-PUBLICLY-18H04564, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-16K18383
[Journal Article] Cu/Zn-superoxide dismutase forms fibrillar hydrogels in a pH-dependent manner via a water-rich extended intermediate state2018
- Author(s)
  Fujiwara Noriko、Wagatsuma Michiru、Oba Naoto、Yoshihara Daisaku、Tokuda Eiichi、Sakiyama Haruhiko、Eguchi Hironobu、Ichihashi Motoko、Furukawa Yoshiaki、Inoue Tadashi、Suzuki Keiichiro
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 10 Pages: e0205090-e0205090
- DOI
  10.1371/journal.pone.0205090
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05705, KAKENHI-PUBLICLY-18H04564, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-16K13060, KAKENHI-PROJECT-17K15077
[Journal Article] Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment2018
- Author(s)
  Okuzumi Ayami、Kurosawa Masaru、Hatano Taku、Takanashi Masashi、Nojiri Shuuko、Fukuhara Takeshi、Yamanaka Tomoyuki、Miyazaki Haruko、Yoshinaga Saki、Furukawa Yoshiaki、Shimogori Tomomi、Hattori Nobutaka、Nukina Nobuyuki
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 6 Issue: 1 Pages: 96-96
- DOI
  10.1186/s40478-018-0587-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17KT0131, KAKENHI-PUBLICLY-17H05705, KAKENHI-PUBLICLY-18H04564, KAKENHI-PROJECT-17H01564, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-18H02723, KAKENHI-PROJECT-15K06762, KAKENHI-PROJECT-16K09675, KAKENHI-PROJECT-18H00446, KAKENHI-PROJECT-17KT0130
[Journal Article] A copper-deficient form of mutant cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis2018
- Author(s)
  Tokuda Eiichi、Nomura Takao、Ohara Shinji、Watanabe Seiji、Yamanaka Koji、Morisaki Yuta、Misawa Hidemi、Furukawa Yoshiaki
- Journal Title
  
  Biochimica et Biophysica Acta - Molecular Basis of Disease
  
  Volume: 印刷中 Issue: 6 Pages: 2119-2130
- DOI
  10.1016/j.bbadis.2018.03.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05705, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-16K16634, KAKENHI-PROJECT-18K05329, KAKENHI-PUBLICLY-18H04860, KAKENHI-PROJECT-17H04986, KAKENHI-PROJECT-17K15077
[Journal Article] Pathological roles of copper dynamics in amyotrophic lateral sclerosis2018
- Author(s)
  古川良明
- Journal Title
  
  生化学
  
  Volume: 90 Issue: 3 Pages: 311-319
- DOI
  10.14952/SEIKAGAKU.2018.900311
- ISSN
  0037-1017
- Year and Date
  2018-06-25
- Language
  Japanese
- Data Source
  KAKENHI-PUBLICLY-17H05705, KAKENHI-PUBLICLY-18H04564, KAKENHI-PROJECT-16H04768
[Journal Article] An essential role of N-terminal domain of copper chaperone in the enzymatic activation of Cu/Zn-superoxide dismutase2017
- Author(s)
  Fukuoka Mami、Tokuda Eiichi、Nakagome Kenta、Wu Zhiliang、Nagano Isao、Furukawa Yoshiaki
- Journal Title
  
  Journal of Inorganic Biochemistry
  
  Volume: 175 Pages: 208-216
- DOI
  10.1016/j.jinorgbio.2017.07.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15077, KAKENHI-PUBLICLY-17H05705, KAKENHI-PROJECT-16H04768
[Journal Article] Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis2017
- Author(s)
  Eiichi Tokuda, Itsuki Anzai, Takao Nomura, Keisuke Toichi, Masahiko Watanabe, Shinji Ohara, Seiji Watanabe, Koji Yamanaka, Yuta Morisaki, Hidemi Misawa, and Yoshiaki Furukawa
- Journal Title
  
  Molecular Neurodegeneration
  
  Volume: 12 Issue: 1 Pages: 2-2
- DOI
  10.1186/s13024-016-0145-9
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01566, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-15K14480, KAKENHI-PROJECT-25860252
[Journal Article] Abnormal protein oligomers for neurodegeneration2017
- Author(s)
  Tokuda Eiichi、Furukawa Yoshiaki
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 25 Pages: 39943-39944
- DOI
  10.18632/oncotarget.18030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15077, KAKENHI-PUBLICLY-17H05705, KAKENHI-PROJECT-16H04768
[Journal Article] Aggregation of FET Proteins as a Pathological Change in Amyotrophic Lateral Sclerosis2017
- Author(s)
  Furukawa Yoshiaki、Tokuda Eiichi
- Journal Title
  
  Advances in Experimental Medicine and Biology
  
  Volume: 925 Pages: 1-12
- DOI
  10.1007/5584_2016_32
- ISBN
  9789811037092, 9789811037108
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05705, KAKENHI-PROJECT-16H04768
[Journal Article] Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA312017
- Author(s)
  Taro Ishiguro, Nozomu Sato, Morio Ueyama, Nobuhiro Fujikake, Chantal Sellier, Akemi Kanegami, Eiichi Tokuda, Bita Zamiri, Terence Gall-Duncan, Mila Mirceta, Yoshiaki Furukawa, 他８名
- Journal Title
  
  Neuron
  
  Volume: 94 Issue: 1 Pages: 108-124
- DOI
  10.1016/j.neuron.2017.02.046
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01566, KAKENHI-PROJECT-15H06181, KAKENHI-PROJECT-15H06588, KAKENHI-PROJECT-17K15077, KAKENHI-PROJECT-16H05325, KAKENHI-PROJECT-15K09331
[Journal Article] A misfolded dimer of Cu/Zn-superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis2017
- Author(s)
  Itsuki Anzai, Eiichi Tokuda, Atsushi Mukaiyama, Shuji Akiyama, Fumito Endo, Koji Yamanaka, Hidemi Misawa, and Yoshiaki Furukawa
- Journal Title
  
  Protein Science
  
  Volume: 26 Issue: 3 Pages: 484-496
- DOI
  10.1002/pro.3094
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01566, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-15H06588, KAKENHI-PROJECT-15K14480, KAKENHI-PROJECT-16K09671
[Journal Article] Copper homeostasis as a therapeutic target in amyotrophic lateral sclerosis with SOD1 mutations2016
- Author(s)
  Eiichi Tokuda and Yoshiaki Furukawa
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 17 Issue: 5 Pages: 636-636
- DOI
  10.3390/ijms17050636
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H04768
[Journal Article] Screening of Drugs Inhibiting In vitro Oligomerization of Cu/Zn-Superoxide Dismutase with a Mutation Causing Amyotrophic Lateral Sclerosis2016
- Author(s)
  Itsuki Anzai, Keisuke Toichi, Eiichi Tokuda, Atsushi Mukaiyama, Shuji Akiyama, and Yoshiaki Furukawa
- Journal Title
  
  Frontiers in Molecular Biosciences
  
  Volume: 3 Pages: 40-40
- DOI
  10.3389/fmolb.2016.00040
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01566, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-15H06588, KAKENHI-PROJECT-15K14480
[Journal Article] A molecular mechanism realizing sequence-specific recognition of nucleic acids by TDP-432016
- Author(s)
  Yoshiaki Furukawa, Yoh Suzuki, Mami Fukuoka, Kenichi Nagasawa, Kenta Nakagome, Hideaki Shimizu, Atsushi Mukaiyama, and Shuji Akiyama
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 20576-20576
- DOI
  10.1038/srep20576
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14480, KAKENHI-PUBLICLY-15H01566, KAKENHI-PROJECT-25291028
[Journal Article] Aggregation of FET Proteins as a Pathological Change in Amyotrophic Lateral Sclerosis2016
- Author(s)
  Yoshiaki Furukawa and Eiichi Tokuda
- Journal Title
  
  Protein Reviews
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14480
[Journal Article] Aggregation of FET Proteins as a Pathological Change in Amyotrophic Lateral Sclerosis2016
- Author(s)
  Yoshiaki Furukawa and Eiichi Tokuda
- Journal Title
  
  Protein Reviews
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25291028
[Journal Article] Conformational Disorder of the Most Immature Cu,Zn-Superoxide Dismutase Leading to Amyotrophic Lateral Sclerosis2016
- Author(s)
  Yoshiaki Furukawa, Itsuki Anzai, Shuji Akiyama, Mizue Imai, Fatima Joy Consul Cruz, Tomohide Saio, Kenichi Nagasawa, Takao Nomura, and Koichiro Ishimori
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 291 Issue: 8 Pages: 4144-4155
- DOI
  10.1074/jbc.m115.683763
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14480, KAKENHI-PUBLICLY-15H01566, KAKENHI-PROJECT-25291028
[Journal Article] Aggregation of FET proteins as a pathological chage in amyotrophic lateral sclerosis2016
- Author(s)
  Yoshiaki Furukawa and Eiichi Tokuda
- Journal Title
  
  Protein Reviews
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01566
[Journal Article] Cysteine residues in Cu,Zn-superoxide dismutase are essential to toxicity in Caenorhabditis elegans model of amyotrophic lateral sclerosis2015
- Author(s)
  Mariko Ogawa, Hisashi Shidara, Kotaro Oka, Masaru Kurosawa, Nobuyuki Nukina, and Yoshiaki Furukawa
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 463 Issue: 4 Pages: 1196-1202
- DOI
  10.1016/j.bbrc.2015.06.084
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14480, KAKENHI-PUBLICLY-15H01566, KAKENHI-PROJECT-25291028
[Journal Article] A seeded propagation of Cu,Zn-superoxide dismutase aggregates in amyotrophic lateral sclerosis2014
- Author(s)
  Mariko Ogawa and Yoshiaki Furukawa
- Journal Title
  
  Frontiers in Cellular Neuroscience
  
  Volume: 8 Pages: 1-5
- DOI
  10.3389/fncel.2014.00083
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111542, KAKENHI-PROJECT-24657093, KAKENHI-PROJECT-25291028
[Journal Article] A primary role for disulfide formation in the productive folding of prokaryotic Cu,Zn-superoxide dismutase2014
- Author(s)
  Yasuyuki Sakurai, Itsuki Anzai, and Yoshiaki Furukawa
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 289 Issue: 29 Pages: 20139-20149
- DOI
  10.1074/jbc.m114.567677
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25291028
[Journal Article] Intranuclear aggregation of mutant FUS/TLS as a molecular pathomechanism of amyotrophic lateral sclerosis2014
- Author(s)
  Nomura, T., Watanabe, S., Kaneko, K., Yamanaka, K., Nukina, N. & Furukawa, Y.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 289 Issue: 2 Pages: 1192-1202
- DOI
  10.1074/jbc.m113.516492
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22110004, KAKENHI-PLANNED-23111006, KAKENHI-PUBLICLY-24111542, KAKENHI-PROJECT-24657093, KAKENHI-PROJECT-24659436, KAKENHI-PROJECT-25291028
[Journal Article] Intracellular seeded aggregation of mutant Cu,Zn-superoxide dismutase associated with amyotrophic lateral sclerosis2013
- Author(s)
  Furukawa, Y., Kaneko, K., Watanabe, S., Yamanaka, K. & Nukina, N.
- Journal Title
  
  FEBS Lett.
  
  Volume: 587 Issue: 16 Pages: 2500-2505
- DOI
  10.1016/j.febslet.2013.06.046
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22110004, KAKENHI-PLANNED-23111006, KAKENHI-PUBLICLY-24111542, KAKENHI-PROJECT-24657093, KAKENHI-PROJECT-24659436, KAKENHI-PROJECT-25291028
[Journal Article] Disulfide scrambling describes the oligomer formation of SOD1 proteins in the familial form of ALS2013
- Author(s)
  Keisuke Toichi, Koji Yamanaka, and Yoshiaki Furukawa
- Journal Title
  
  The J ournal of Biological Chemistry
  
  Volume: 288巻 Issue: 7 Pages: 4970-4980
- DOI
  10.1074/jbc.m112.414235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24657093, KAKENHI-PUBLICLY-24111542
[Journal Article] Functional diversity of protein fibrillar aggregates from physiology to RNA granules to neurodegenerative diseases2013
- Author(s)
  Furukawa, Y. & Nukina, N.
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: 1832 Issue: 8 Pages: 1271-1278
- DOI
  10.1016/j.bbadis.2013.04.011
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22110004, KAKENHI-PUBLICLY-24111542, KAKENHI-PROJECT-24657093, KAKENHI-PROJECT-24659436, KAKENHI-PROJECT-25253066
[Journal Article] Redox environment is an intracellular factor to operate distinct pathways for aggregation of Cu,Zn-superoxide dismutase in amyotrophic lateral sclerosis2013
- Author(s)
  Yoshiaki Furukawa
- Journal Title
  
  Frontiers in Cellular Neuroscience
  
  Volume: 7 Pages: 1-9
- DOI
  10.3389/fncel.2013.00240
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111542, KAKENHI-PROJECT-24657093, KAKENHI-PROJECT-25291028
[Journal Article] Post-aggregation oxidation of mutant huntingtin controls the interactions between aggregates2012
- Author(s)
  Mitomi, Y.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 287 Issue: 41 Pages: 34764-34775
- DOI
  10.1074/jbc.m112.387035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240037, KAKENHI-PROJECT-24659436, KAKENHI-PLANNED-22110004, KAKENHI-PUBLICLY-24111542
[Journal Article] Local Unfolding of Cu, Zn Superoxide Dismutase Monomer Determines the Morphology of Fibrillar Aggregates2012
- Author(s)
  Feng Ding, Yoshiaki Furukawa, Nobuyuki Nukina, and Nikolay V. Dokholyan
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770162
[Journal Article] Pathological Roles of Wild-Type Cu,Zn-Superoxide Dismutase in Amyotrophic Lateral Sclerosis2012
- Author(s)
  Yoshiaki Furukawa
- Journal Title
  
  Neurology Research International
  
  Volume: 2012 Pages: 1-6
- DOI
  10.1155/2012/323261
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111542
[Journal Article] Local unfolding of Cu, Zn superoxide dismutase monomer determines the morphology of fibrillar aggregates2012
- Author(s)
  Ding, F.
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: 421 Issue: 4-5 Pages: 548-560
- DOI
  10.1016/j.jmb.2011.12.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240037, KAKENHI-PROJECT-22770162, KAKENHI-PROJECT-24659436, KAKENHI-PLANNED-22110004
[Journal Article] A Seeding Reaction Recapitulates Intracellular Formation of Sarkosyl-insoluble Transactivation Response Element(TAR) DNA-binding Protein-43 Inclusions2011
- Author(s)
  Yoshiaki Furukawa, Kumi Kaneko, Shoji Watanabe, Koji Yamanaka, and Nobuyuki Nukina
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 286 Pages: 18664-18672
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770162
[Journal Article] Molecular properties of TAR DNA binding protein-43 fragments are dependent upon its cleavage site2011
- Author(s)
  Yoshiaki Furukawa, Kumi Kaneko, Nobuyuki Nukina
- Journal Title
  
  Biochimica et Biophysica Acta
  
  Volume: 1812 Issue: 12 Pages: 1577-1583
- DOI
  10.1016/j.bbadis.2011.09.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770162
[Journal Article] A seeding reaction recapitulates intracellular formation of Sarkosyl-insoluble transactivation response element (TAR) DNA-binding protein-43 inclusions2011
- Author(s)
  Furukawa, Y., et al
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Issue: 21 Pages: 18664-18672
- DOI
  10.1074/jbc.m111.231209
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22110004, KAKENHI-PROJECT-22240037, KAKENHI-PROJECT-22770162
[Journal Article] Tau Protein Assembles into Isoform-and Disulfide-dependent Polymorphic Fibrils with Distinct Structural Properties2011
- Author(s)
  Yoshiaki Furukawa, Kumi Kaneko, and Nobuyuki Nukina
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 286 Pages: 27236-27246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770162
[Journal Article] Molecular Properties of TAR DNA Binding Protein-43 Fragments are Dependent upon Its Cleavage Site2011
- Author(s)
  Yoshiaki Furukawa, Kumi Kaneko, and Nobuyuki Nukina
- Journal Title
  
  Biochimica et Biophysica Acta
  
  Volume: 1812 Pages: 1577-1583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770162
[Journal Article] Tau protein assembles into isoform- and disulfide-dependent polymorphic fibrils with distinct structural properties2011
- Author(s)
  Furukawa, Y., et al
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Issue: 31 Pages: 27236-27246
- DOI
  10.1074/jbc.m111.248963
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22110004, KAKENHI-PROJECT-22770162
[Journal Article] A seeding reaction recapitulates intracellular formation of sarkosyl-insoluble TAR DNA binding protein-43 inclusions2011
- Author(s)
  Yoshiaki Furukawa, et al.
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: (掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770162
[Journal Article] Mutant huntingtin fragment selectively suppresses Brn-2 POU domain transcription factor to mediate hypothalamic cell dysfunction2010
- Author(s)
  Tomoyuki Yamanaka, Asako Tosaki, Haruko Miyazaki, Masaru Kurosawa, Yoshiaki Furukawa, Mizuki Yamada, Nobuyuki Nukina
- Journal Title
  
  Human Molecular Genetics (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770130
[Journal Article] タンパク質線維の構造伝播が制御する神経変性疾患の発症メカニズム2010
- Author(s)
  古川良明
- Journal Title
  
  生物物理
  
  Volume: 50 Pages: 242-243
- NAID
  10026670700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770162
[Journal Article] Mutation-dependent polymorphism of Cu, Zn-superoxide dismutase aggregates in the familial form of amyotrophic lateral sclerosis2010
- Author(s)
  Yoshiaki Furukawa, Kumi Kaneko, Koji Yamanaka, Nobuyuki Nukina
- Journal Title
  
  The Journal of Biological Chemistry (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770130
[Journal Article] Cross-seeding Fibrillation of Q/N-rich Proteins Offers New Pathomechanism of Polyglutamine Diseases2009
- Author(s)
  Yoshiaki Furukawa, Kumi Kaneko, Gen Matsumoto, Masaru Kurosawa, Nobuyuki Nukina
- Journal Title
  
  The Journal of Neuroscience 29
  
  Pages: 5153-5162
- NAID
  10026670700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770130
[Journal Article] 翻訳後修飾が制御するSOD1蛋白質の活性化と凝集のメカニズム2009
- Author(s)
  古川良明
- Journal Title
  
  生物物理 49
  
  Pages: 90-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770130
[Journal Article] 翻訳後修飾が制御するSOD1蛋白質の活性化と凝集のメカニズム2009
- Author(s)
  古川良明
- Journal Title
  
  生物物理 49(印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770130
[Journal Article] Cross-seeding Fibrillation of Q/N-rich Proteins Offers New Pathomechanism of Polyglutamine Diseases2009
- Author(s)
  古川良明 et al.
- Journal Title
  
  The Journal of Neuroscience 29
  
  Pages: 5153-5162
- NAID
  10026670700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770130
[Journal Article] Complete Loss of Post-translational Modifications Triggers Fibrillar Aggregation of SOD1 in the Familial Form of Amyotrophic Lateral Sclerosis2008
- Author(s)
  Yoshiaki Furukawa, Kumi Kaneko, Koji Yamanaka, Thomas V. O'Halloran, Nobuyuki Nukina
- Journal Title
  
  The Journal of Biological Chemistry 283
  
  Pages: 24167-24176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770130
[Journal Article] RNA-binding protein TLS is a major nuclear aggregate-interacting protein in Huntingtin exon 1 with expanded polyglutamine-expressing cells.2008
- Author(s)
  Doi H., Okamura K., Bauer P. O., Furukawa Y, Shimizu H., Kurosawa M., Machida Y., Miyazaki H., Mitsui K., Kuroiwa Y., and Nukina N.
- Journal Title
  
  The Journal of Biological Chemistry 283
  
  Pages: 6489-6500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18770143
[Journal Article] RNA-binding Protein TLS Is a Major Nuclear Aggregate-interacting Protein in Huntingtin Exon 1 with Expanded Polyglutamine-expressing Cells2008
- Author(s)
  Hiroshi Doi, Kazumasa Okamura, Peter O. Bauer, Yoshiaki Furukawa, Hideaki Shimizu, Masaru Kurosawa, Yoko Machida, Haruko Miyazaki, Kenichi Mitsui, Yoshiyuki Kuroiwa, Nobuyuki Nukina
- Journal Title
  
  The Journal of Biological Chemistry 283
  
  Pages: 6489-6500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770130
[Journal Article] Complete loss of post-translational modifications triggers, fibrillar aggregation of SOD1 in the familial form of amyotrophic lateral sclerosis2008
- Author(s)
  Yoshiaki Furukawa
- Journal Title
  
  The Journal of Biological Chemistry 283
  
  Pages: 24167-24176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770130
[Journal Article] RNA-binding protein TLS is a major nuclear aggregate-interacting protein in Huntingtin exon 1 with expanded polyglutamine-expressing cells.2007
- Author(s)
  Doi H., Okamura K., Bauer P.O., Furukawa Y., Shimizu H., Kurosawa M., Machida Y., Miyazaki H., Mitsui K., Kuroiwa Y., and Nukina N.
- Journal Title
  
  The Journal of Biological Chemistry (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18031044
[Journal Article] Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu,Zn-superoxide dismutase aggregates in spinal cords of model mice2006
- Author(s)
  Furukawa, Y. et al.
- Journal Title
  
  Proceedings of the National Academy of Sciences, USA 103
  
  Pages: 7148-7153
- Data Source
  KAKENHI-PROJECT-18031044
[Journal Article] Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria2006
- Author(s)
  Deng, H-X., Shi, Y., Furukawa, Y.et al.
- Journal Title
  
  Proceedings of the National Academy of Sciences, USA 103
  
  Pages: 7142-7147
- Data Source
  KAKENHI-PROJECT-18031044
[Journal Article] Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu,Zn-superoxide dismutase aggregates in spinal cords of model mice2006
- Author(s)
  Furukawa, Y. et al.
- Journal Title
  
  Proceedings of the National Academy of Sciences, USA 103
  
  Pages: 7148-7153
- Data Source
  KAKENHI-PROJECT-18770143
[Journal Article] Post-translational modifications in Cu,Zn-superoxide dismutase and mutations associated with ALS2006
- Author(s)
  Furukawa, Y., O'Halloran, T.V.
- Journal Title
  
  Antioxidants ＆ Redox Signaling 8
  
  Pages: 847-867
- Data Source
  KAKENHI-PROJECT-18031044
[Journal Article] Post-translational modifications in Cu,Zn-superoxide dismutase and mutations associated with ALS2006
- Author(s)
  Furukawa, Y., O'Halloran, T.V.
- Journal Title
  
  Antioxidants ＆ Redox Signaling 8
  
  Pages: 847-867
- Data Source
  KAKENHI-PROJECT-18770143
[Journal Article] Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria2006
- Author(s)
  Deng, H-X., Shi, Y., Furukawa, Y.et al.
- Journal Title
  
  Proceedings of the National Academy of Sciences, USA 103
  
  Pages: 7142-7147
- Data Source
  KAKENHI-PROJECT-18770143
[Presentation] 銅・亜鉛スーパーオキシドディスムターゼの成熟化を通じて理解する生体内銅動態の重要性2024
- Author(s)
  古川良明
- Organizer
  第65回日本植物生理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24031
[Presentation] 銅・亜鉛スーパーオキシドディスムターゼの成熟化を通じて理解する生体内銅動態の重要性2024
- Author(s)
  古川良明
- Organizer
  第65回日本植物生理学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] システイン残基の酸化に伴うSOD1のミスフォールディングと筋萎縮性側索硬化症2023
- Author(s)
  吉田萌乃、明石知子、田尻道子、村木則文、古川良明
- Organizer
  メタルバイオサイエンス研究会2023
- Data Source
  KAKENHI-PROJECT-23K24031
[Presentation] 変性性脊髄症における変異型SOD1の凝集メカニズム2023
- Author(s)
  篠宥毅、小畠結、神志那弘明、加藤龍一、村木則文、古川良明
- Organizer
  メタルバイオサイエンス研究会2023
- Data Source
  KAKENHI-PROJECT-23K24031
[Presentation] 組織特異的な金属ホメオスタシスが神経変性疾患の病理に果たす役割2023
- Author(s)
  古川良明
- Organizer
  第23回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] デイノコッカス属細菌に見られる新規マルチドメイン型の銅・亜鉛スーパーオキシドディスムターゼ2023
- Author(s)
  古川良明、目加田祐道、新谷敦子、須恵香里、村木則文
- Organizer
  第49回生体分子科学討論会
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] 組織特異的な金属ホメオスタシスが神経変性疾患の病理に果たす役割2023
- Author(s)
  古川良明
- Organizer
  第23回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24031
[Presentation] 筋萎縮性側索硬化症における銅・亜鉛スーパーオキシドディスムターゼのミスフォールディング機序2023
- Author(s)
  古川　良明
- Organizer
  第25回日本亜鉛栄養治療研究会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19389
[Presentation] 組織特異的な金属ホメオスタシスが神経変性疾患の病理に果たす役割2023
- Author(s)
  古川良明
- Organizer
  第23回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19389
[Presentation] フラグメント抗体を利用した変性性脊髄症関連タンパク質SOD1の構造解析2023
- Author(s)
  篠宥毅、小畠結、神志那弘明、村木則文、古川良明
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K24031
[Presentation] 生命現象を司る金属ホメオスタシスの理解2023
- Author(s)
  古川、澤井
- Organizer
  第23回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05760
[Presentation] 筋萎縮性側索硬化症における銅・亜鉛スーパーオキシドディスムターゼのミスフォールディング機序2023
- Author(s)
  古川　良明
- Organizer
  第 25 回日本亜鉛栄養治療研究会学術集会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] 神経変性疾患に見られる酸化的環境下でのSOD1タンパク質の構造異常化メカニズム2023
- Author(s)
  吉田萌乃、村木則文、秋山修志、古川良明
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K24031
[Presentation] Bacterial Cu/Zn-Superoxide Dismutase with a Novel Fold2022
- Author(s)
  Yoshiaki Furukawa, Shuhei Narikiyo, Masato Akutsu, Atsuko Shintani
- Organizer
  The 8th International Symposium on Metallomics
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] 神経変性疾患にみられる SOD1 タンパク質への酸化修飾と構造異常化のメカニズム2022
- Author(s)
  古川　良明
- Organizer
  第 95 回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] Bacterial Cu/Zn-Superoxide Dismutase with a Novel Fold2022
- Author(s)
  Yoshiaki Furukawa, Shuhei Narikiyo, Masato Akutsu, Atsuko Shintani
- Organizer
  The 8th International Symposium on Metallomics
- Data Source
  KAKENHI-PROJECT-22K19389
[Presentation] What Triggers Misfolding of Cu/Zn-Superoxide Dismutase in Neurodegenerative Diseases?2022
- Author(s)
  Yoshiaki Furukawa
- Organizer
  0th Asian Biological Inorganic Chemistry Conference (AsBIC10)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] 神経変性疾患にみられるSOD1タンパク質への酸化修飾と構造異常化のメカニズム2022
- Author(s)
  古川　良明
- Organizer
  第95回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19389
[Presentation] What Triggers Misfolding of Cu/Zn-Superoxide Dismutase in Neurodegenerative Diseases?2022
- Author(s)
  Yoshiaki Furukawa
- Organizer
  10th Asian Biological Inorganic Chemistry Conference (AsBIC10)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19389
[Presentation] 酸化ストレスに伴う金属タンパク質のミスフォールディングと神経変性疾患2021
- Author(s)
  古川良明
- Organizer
  第74回日本酸化ストレス学会・第21回日本NO学会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] 細胞内で金属イオンを失ったSOD1タンパク質が辿る運命2021
- Author(s)
  古川良明
- Organizer
  第21回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] 筋萎縮性側索硬化症における生命金属動態の破綻とSOD1タンパク質のミスフォールディング2021
- Author(s)
  古川良明
- Organizer
  メタルバイオサイエンス研究会2021
- Invited
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] Mechanism of Copper Acquisition by Bacterial Cu/Zn-Superoxide Dismutase2021
- Author(s)
  Yoshiaki Furukawa
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] A dual role of cysteine residues in the maturation of prokaryotic Cu/Zn-superoxide dismutase2021
- Author(s)
  古川良明
- Organizer
  第59回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] 筋萎縮性側索硬化症に見られるタンパク質凝集のメカニズム2021
- Author(s)
  古川良明
- Organizer
  第8回日本アミロイドーシス学会学術集会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] 銅・亜鉛スーパーオキシドディスムターゼへの金属イオン結合の解析2021
- Author(s)
  古川良明、田尻道子、明石知子
- Organizer
  第47回生体分子科学討論会
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] 大腸菌におけるスーパーオキシドディスムターゼの銅イオン獲得メカニズム2020
- Author(s)
  古川　良明
- Organizer
  日本農芸化学会大会2020
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04564
[Presentation] 線虫をモデルにした筋萎縮性側索硬化症関連タンパク質SOD1の毒性評価2020
- Author(s)
  古川　良明
- Organizer
  第61回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21290
[Presentation] 大腸菌におけるスーパーオキシドディスムターゼの銅イオン獲得メカニズム2020
- Author(s)
  古川　良明
- Organizer
  日本農芸化学会大会2020
- Invited
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] 大腸菌におけるスーパーオキシドディスムターゼの銅イオン獲得メカニズム2020
- Author(s)
  古川　良明
- Organizer
  日本農芸化学会大会2020
- Invited
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] A misfolding of Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis2019
- Author(s)
  Yoshiaki Furukawa
- Organizer
  The 10th APRU Population Aging Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] Misfolded SOD1 as a pathological species in sporadic forms of amyotrophic lateral sclerosis2019
- Author(s)
  Yoshiaki Furukawa
- Organizer
  The 4th Joint Conference between KMU and Keio University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] タンパク質のミスフォールディングがもたらす神経変性疾患2019
- Author(s)
  古川　良明
- Organizer
  医工連携シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] 神経変性疾患関連タンパク質SOD1の自己酸化によるミスフォールディング機構2019
- Author(s)
  安齋　樹、徳田　栄一、向山　厚、秋山　修志、古川　良明
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] Demetallated Cu/Zn-superoxide dismutase as a pathogenic entity causing neurodegeneration2019
- Author(s)
  Yoshiaki Furukawa
- Organizer
  Biometal Science
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] 大腸菌における銅・亜鉛スーパーオキシドディスムターゼの生理的役割2019
- Author(s)
  古川　良明、吉田　昴生
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] A misfolding of Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis2019
- Author(s)
  Yoshiaki Furukawa
- Organizer
  The 10th APRU Population Aging Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04564
[Presentation] A misfolding of Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis2019
- Author(s)
  Yoshiaki Furukawa
- Organizer
  The 10th APRU Population Aging Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] 大腸菌における銅・亜鉛スーパーオキシドディスムターゼの生理的役割2019
- Author(s)
  古川　良明、吉田　昴生
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] Demetallated Cu/Zn-superoxide dismutase as a pathogenic entity causing neurodegeneration2019
- Author(s)
  Yoshiaki Furukawa
- Organizer
  Towards a cure for amyloid diseases: a successful example of precision and translational medicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] Demetallated Cu/Zn-superoxide dismutase as a pathogenic entity causing neurodegeneration2019
- Author(s)
  Yoshiaki Furukawa
- Organizer
  Towards a cure for amyloid diseases: a successful example of precision and translational medicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04564
[Presentation] Demetallated Cu/Zn-superoxide dismutase as a pathogenic entity causing neurodegeneration2019
- Author(s)
  Yoshiaki Furukawa
- Organizer
  Biometal Science
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04564
[Presentation] 銅シャペロンCCSがSOD1タンパク質に銅イオンを供給するメカニズム2019
- Author(s)
  羽飼　友昭、福岡　真実、古川　良明
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] Demetallated Cu/Zn-superoxide dismutase as a pathogenic entity causing neurodegeneration2019
- Author(s)
  Yoshiaki Furukawa
- Organizer
  Biometal Science
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] タンパク質のミスフォールディングがもたらす神経変性疾患2019
- Author(s)
  古川　良明
- Organizer
  医工連携シンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04564
[Presentation] 神経変性疾患関連タンパク質SOD1の自己酸化によるミスフォールディング機構2019
- Author(s)
  安齋　樹、徳田　栄一、向山　厚、秋山　修志、古川　良明
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] 大腸菌における銅・亜鉛スーパーオキシドディスムターゼの生理的役割2019
- Author(s)
  古川　良明、吉田　昴生
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PUBLICLY-18H04564
[Presentation] A misfolding mechanism of Cu/Zn-superoxide dismutase under oxidative conditions of amyotrophic lateral sclerosis2019
- Author(s)
  Yoshiaki Furukawa, Itsuki Anzai, Eiichi Tokuda, Atsushi Mukaiyama, Shuji Akiyama
- Organizer
  15th International Symposium on Applied Bioinorganic Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04564
[Presentation] A misfolding mechanism of Cu/Zn-superoxide dismutase under oxidative conditions of amyotrophic lateral sclerosis2019
- Author(s)
  Yoshiaki Furukawa, Itsuki Anzai, Eiichi Tokuda, Atsushi Mukaiyama, Shuji Akiyama
- Organizer
  15th International Symposium on Applied Bioinorganic Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] タンパク質のミスフォールディングがもたらす神経変性疾患2019
- Author(s)
  古川　良明
- Organizer
  医工連携シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] Demetallated Cu/Zn-superoxide dismutase as a pathogenic entity causing neurodegeneration2019
- Author(s)
  Yoshiaki Furukawa
- Organizer
  Towards a cure for amyloid diseases: a successful example of precision and translational medicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] Misfolded SOD1 as a pathological species in sporadic forms of amyotrophic lateral sclerosis2019
- Author(s)
  Yoshiaki Furukawa
- Organizer
  The 4th Joint Conference between KMU and Keio University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04564
[Presentation] 銅シャペロンCCSがSOD1タンパク質に銅イオンを供給するメカニズム2019
- Author(s)
  羽飼　友昭、福岡　真実、古川　良明
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] 銅シャペロンCCSがSOD1タンパク質に銅イオンを供給するメカニズム2019
- Author(s)
  羽飼　友昭、福岡　真実、古川　良明
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PUBLICLY-18H04564
[Presentation] A misfolding mechanism of Cu/Zn-superoxide dismutase under oxidative conditions of amyotrophic lateral sclerosis2019
- Author(s)
  Yoshiaki Furukawa, Itsuki Anzai, Eiichi Tokuda, Atsushi Mukaiyama, Shuji Akiyama
- Organizer
  15th International Symposium on Applied Bioinorganic Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] バクテリアにおける銅・亜鉛スーパーオキシドディスムターゼの生理的役割2019
- Author(s)
  古川　良明、吉田　昂生、草野　孝央、高橋　愛海
- Organizer
  メタルバイオサイエンス研究会2019
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] バクテリアにおける銅・亜鉛スーパーオキシドディスムターゼの生理的役割2019
- Author(s)
  古川　良明、吉田　昂生、草野　孝央、高橋　愛海
- Organizer
  メタルバイオサイエンス研究会2019
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] バクテリアにおける銅・亜鉛スーパーオキシドディスムターゼの生理的役割2019
- Author(s)
  古川　良明、吉田　昂生、草野　孝央、高橋　愛海
- Organizer
  メタルバイオサイエンス研究会2019
- Data Source
  KAKENHI-PUBLICLY-18H04564
[Presentation] Misfolded SOD1 as a pathological species in sporadic forms of amyotrophic lateral sclerosis2019
- Author(s)
  Yoshiaki Furukawa
- Organizer
  The 4th Joint Conference between KMU and Keio University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05765
[Presentation] 神経変性疾患関連タンパク質SOD1の自己酸化によるミスフォールディング機構2019
- Author(s)
  安齋　樹、徳田　栄一、向山　厚、秋山　修志、古川　良明
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PUBLICLY-18H04564
[Presentation] Metal-deficiency in Cu/Zn-superoxide dismutase: a potential cause of motor neuron disease, ALS2018
- Author(s)
  Yoshiaki Furukawa
- Organizer
  9th Asian Biological Inorganic Chemistry Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05705
[Presentation] Wild-type SOD1 is misfolded in cerebrospinal fluid of sporadic ALS2018
- Author(s)
  Yoshiaki Furukawa, Eiichi Tokuda, Shinji Ohara, Noriko Fujiwara
- Organizer
  22nd International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] A mechanism on copper acquisition of bacterial Cu/Zn-superoxide dismutase2018
- Author(s)
  古川良明
- Organizer
  第５６回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] Factors controlling expression levels of periplasmic Cu/Zn-superoxide dismutase in Escherichia coli2018
- Author(s)
  Koki Yoshida and Yoshiaki Furukawa
- Organizer
  9th Asian Biological Inorganic Chemistry Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05705
[Presentation] Conformation-dependent toxicity of Cu/Zn-superoxide dismutase in Caenorhabditis elegans2018
- Author(s)
  Ayano Toba, Eiichi Tokuda, and Yoshiaki Furukawa
- Organizer
  9th Asian Biological Inorganic Chemistry Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05705
[Presentation] A mechanism on copper acquisition of bacterial Cu/Zn-superoxide dismutase2018
- Author(s)
  古川良明
- Organizer
  第５６回日本生物物理学会年会
- Data Source
  KAKENHI-PUBLICLY-17H05705
[Presentation] 筋萎縮性側索硬化症における銅・亜鉛結合タンパク質SOD1のミスフォールディングメカニズム2018
- Author(s)
  古川良明
- Organizer
  第18回日本蛋白質科学会年会
- Data Source
  KAKENHI-PUBLICLY-18H04564
[Presentation] Conformation-dependent toxicity of Cu/Zn-superoxide dismutase in Caenorhabditis elegans2018
- Author(s)
  Ayano Toba, Eiichi Tokuda, and Yoshiaki Furukawa
- Organizer
  9th Asian Biological Inorganic Chemistry Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04564
[Presentation] A network for intracellular copper distribution controlled by interactions between copper chaperones2018
- Author(s)
  Kyoka Matsumoto, Kenta Nakagome, and Yoshiaki Furukawa
- Organizer
  9th Asian Biological Inorganic Chemistry Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04564
[Presentation] A network for intracellular copper distribution controlled by interactions between copper chaperones2018
- Author(s)
  Kyoka Matsumoto, Kenta Nakagome, and Yoshiaki Furukawa
- Organizer
  9th Asian Biological Inorganic Chemistry Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] 神経変性疾患に見られる生体内銅イオン動態の異常2018
- Author(s)
  古川良明
- Organizer
  第6回メタロミクス研究フォーラム
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04564
[Presentation] 筋萎縮性側索硬化症における銅・亜鉛結合タンパク質SOD1のミスフォールディングメカニズム2018
- Author(s)
  古川良明
- Organizer
  第１８回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] Wild-type SOD1 is misfolded in cerebrospinal fluid of sporadic ALS2018
- Author(s)
  Yoshiaki Furukawa, Eiichi Tokuda, Shinji Ohara, Noriko Fujiwara
- Organizer
  22nd International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04564
[Presentation] Factors controlling expression levels of periplasmic Cu/Zn-superoxide dismutase in Escherichia coli2018
- Author(s)
  Koki Yoshida and Yoshiaki Furukawa
- Organizer
  9th Asian Biological Inorganic Chemistry Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04564
[Presentation] A misfolding mechanism of Cu/Zn-superoxide dismutase under oxidative conditions of amyotrophic lateral sclerosis2018
- Author(s)
  Itsuki Anzai, Eiichi Tokuda, Atsushi Mukaiyama, Shuji Akiyama, and Yoshiaki Furukawa
- Organizer
  9th Asian Biological Inorganic Chemistry Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05705
[Presentation] Conformation-dependent toxicity of Cu/Zn-superoxide dismutase in Caenorhabditis elegans2018
- Author(s)
  Ayano Toba, Eiichi Tokuda, and Yoshiaki Furukawa
- Organizer
  9th Asian Biological Inorganic Chemistry Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] A network for intracellular copper distribution controlled by interactions between copper chaperones2018
- Author(s)
  Kyoka Matsumoto, Kenta Nakagome, and Yoshiaki Furukawa
- Organizer
  9th Asian Biological Inorganic Chemistry Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05705
[Presentation] 筋萎縮性側索硬化症における銅・亜鉛結合タンパク質SOD1のミスフォールディングメカニズム2018
- Author(s)
  古川良明
- Organizer
  第１８回日本蛋白質科学会年会
- Data Source
  KAKENHI-PUBLICLY-17H05705
[Presentation] Factors controlling expression levels of periplasmic Cu/Zn-superoxide dismutase in Escherichia coli2018
- Author(s)
  Koki Yoshida and Yoshiaki Furukawa
- Organizer
  9th Asian Biological Inorganic Chemistry Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] A misfolding mechanism of Cu/Zn-superoxide dismutase under oxidative conditions of amyotrophic lateral sclerosis2018
- Author(s)
  Itsuki Anzai, Eiichi Tokuda, Atsushi Mukaiyama, Shuji Akiyama, and Yoshiaki Furukawa
- Organizer
  9th Asian Biological Inorganic Chemistry Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04564
[Presentation] Metal-deficiency in Cu/Zn-superoxide dismutase: a potential cause of motor neuron disease, ALS2018
- Author(s)
  Yoshiaki Furukawa
- Organizer
  9th Asian Biological Inorganic Chemistry Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] A misfolding mechanism of Cu/Zn-superoxide dismutase under oxidative conditions of amyotrophic lateral sclerosis2018
- Author(s)
  Itsuki Anzai, Eiichi Tokuda, Atsushi Mukaiyama, Shuji Akiyama, and Yoshiaki Furukawa
- Organizer
  9th Asian Biological Inorganic Chemistry Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] Wild-type SOD1 is misfolded in cerebrospinal fluid of sporadic ALS2018
- Author(s)
  Yoshiaki Furukawa, Eiichi Tokuda, Shinji Ohara, Noriko Fujiwara
- Organizer
  22nd International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05705
[Presentation] 神経変性疾患に見られる生体内銅イオン動態の異常2018
- Author(s)
  古川良明
- Organizer
  第６回メタロミクス研究フォーラム
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05705
[Presentation] Metal-deficiency in Cu/Zn-superoxide dismutase: a potential cause of motor neuron disease, ALS2018
- Author(s)
  Yoshiaki Furukawa
- Organizer
  9th Asian Biological Inorganic Chemistry Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04564
[Presentation] A mechanism on copper acquisition of bacterial Cu/Zn-superoxide dismutase2018
- Author(s)
  古川良明
- Organizer
  第56回日本生物物理学会年会
- Data Source
  KAKENHI-PUBLICLY-18H04564
[Presentation] 神経変性疾患に見られる生体内銅イオン動態の異常2018
- Author(s)
  古川良明
- Organizer
  第６回メタロミクス研究フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] A chaperone-independent maturation mechanism of Cu/Zn-superoxide dismutase2017
- Author(s)
  Yoshiaki Furukawa
- Organizer
  5th Symposium on Advanced Biological Inorganic Chemistry
- Place of Presentation
  Kolkata (India)
- Year and Date
  2017-01-07
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] タンパク質の構造異常を検出できるファージの開発と神経変性疾患の病理解明への応用2017
- Author(s)
  古川良明、徳田栄一、長澤健一、野村尚生、山中宏二、三澤日出巳、大原慎司
- Organizer
  第44回生体分子科学討論会
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] 筋萎縮性側索硬化症にみられる変異型SOD1への金属イオン結合の異常2017
- Author(s)
  古川良明、徳田栄一、大原慎司、山中宏二、三澤日出巳
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PUBLICLY-17H05705
[Presentation] 生体内の銅イオン動態と神経変性疾患2017
- Author(s)
  古川良明
- Organizer
  分子研研究会「生体金属動態」
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05705
[Presentation] Roles of metallochaperone in the activation of Cu/Zn-superoxide dismutase2017
- Author(s)
  古川良明
- Organizer
  第１７回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] A mechanism of enzymatic activation of Cu/Zn-superoxide dismutase by its copper chaperone2017
- Author(s)
  Yoshiaki Furukawa and Mami Fukuoka
- Organizer
  日本生物物理学会第55回年会
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] A chaperone-independent maturation mechanism of Cu/Zn-superoxide dismutase2017
- Author(s)
  Yoshiaki Furukawa
- Organizer
  5th Symposium on Advanced Biological Inorganic Chemistry
- Place of Presentation
  Kolkata (India)
- Year and Date
  2017-01-07
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01566
[Presentation] 生体内の銅イオン動態と神経変性疾患2017
- Author(s)
  古川良明
- Organizer
  分子研研究会「生体金属動態」
- Invited
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] 筋萎縮性側索硬化症における変異SOD1オリゴマーの免疫化学的な検出2017
- Author(s)
  徳田　栄一、森崎　祐太、三澤　日出巳、渡邊　征爾、山中　宏二、大原　慎司、古川　良明
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県・仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PUBLICLY-15H01566
[Presentation] 神経変性疾患の発症に関わるタンパク質のミスフォールディングを抑制する化合物の探索2017
- Author(s)
  半田　純夏、徳田　栄一、古川　良明
- Organizer
  日本化学会第97春季年会
- Place of Presentation
  慶應義塾大学（神奈川県・横浜市）
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PUBLICLY-15H01566
[Presentation] Development of peptides that specifically recognize misfolded SOD1 proteins in amyotrophic lateral sclerosis2017
- Author(s)
  徳田栄一、長澤健一、野村尚生、三澤日出巳、山中宏二、古川良明
- Organizer
  第40回日本神経科学会大会
- Data Source
  KAKENHI-PUBLICLY-17H05705
[Presentation] 筋萎縮性側索硬化症にみられる変異型SOD1への金属イオン結合の異常2017
- Author(s)
  古川良明、徳田栄一、大原慎司、山中宏二、三澤日出巳
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] Development of peptides that specifically recognize misfolded SOD1 proteins in amyotrophic lateral sclerosis2017
- Author(s)
  Eiichi Tokuda, Kenichi Nagasawa, Takao Nomura, Hidemi Misawa, Shinji Ohara, Koji Yamanaka, and Yoshiaki Furukawa
- Organizer
  28th International Symposium on ALS/MND
- Invited
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] 神経変性疾患の発症に関わるタンパク質オリゴマーの形成と毒性発揮のメカニズム2017
- Author(s)
  安齋　樹、徳田　栄一、向山　厚、秋山　修志、古川　良明
- Organizer
  日本化学会第97春季年会
- Place of Presentation
  慶應義塾大学（神奈川県・横浜市）
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PUBLICLY-15H01566
[Presentation] 神経変性疾患に関連したタンパク質の線維化を抑制する化合物の探索2017
- Author(s)
  中村　滉平、徳田　栄一、古川　良明
- Organizer
  日本化学会第97春季年会
- Place of Presentation
  慶應義塾大学（神奈川県・横浜市）
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PUBLICLY-15H01566
[Presentation] Development of peptides that specifically recognize misfolded SOD1 proteins in amyotrophic lateral sclerosis2017
- Author(s)
  Eiichi Tokuda, Kenichi Nagasawa, Takao Nomura, Hidemi Misawa, Shinji Ohara, Koji Yamanaka, and Yoshiaki Furukawa
- Organizer
  28th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05705
[Presentation] A mechanism of enzymatic activation of Cu/Zn-superoxide dismutase by its copper chaperone2017
- Author(s)
  Yoshiaki Furukawa and Mami Fukuoka
- Organizer
  日本生物物理学会第55回年会
- Data Source
  KAKENHI-PUBLICLY-17H05705
[Presentation] タンパク質の構造異常を検出できるファージの開発と神経変性疾患の病理解明への応用2017
- Author(s)
  古川良明、徳田栄一、長澤健一、野村尚生、山中宏二、三澤日出巳、大原慎司
- Organizer
  第44回生体分子科学討論会
- Data Source
  KAKENHI-PUBLICLY-17H05705
[Presentation] Roles of metallochaperone in the activation of Cu/Zn-superoxide dismutase2017
- Author(s)
  古川良明
- Organizer
  第17回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05705
[Presentation] 筋萎縮性側索硬化症に見られる銅・亜鉛結合タンパク質SOD1のミスフォールディングメカニズム2017
- Author(s)
  古川良明
- Organizer
  第5回メタロミクス研究フォーラム
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05705
[Presentation] SOD1-linked familial ALS with marked intrafamilial phenotypic variation. How clinical features relate to pathology?2017
- Author(s)
  Shinji Ohara, Yo-ichi Takei, Akinori Nakamura, Kenya Oguchi, Hidemi Misawa, and Yoshiaki Furukawa
- Organizer
  International Conference on Neurology and Brain Disorders
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05705
[Presentation] SOD1-linked familial ALS with marked intrafamilial phenotypic variation. How clinical features relate to pathology?2017
- Author(s)
  Shinji Ohara, Yo-ichi Takei, Akinori Nakamura, Kenya Oguchi, Hidemi Misawa, and Yoshiaki Furukawa
- Organizer
  International Conference on Neurology and Brain Disorders
- Invited
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] 筋萎縮性側索硬化症に見られる銅・亜鉛結合タンパク質SOD1のミスフォールディングメカニズム2017
- Author(s)
  古川良明
- Organizer
  第５回メタロミクス研究フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] Development of peptides that specifically recognize misfolded SOD1 proteins in amyotrophic lateral sclerosis2017
- Author(s)
  徳田栄一、長澤健一、野村尚生、三澤日出巳、山中宏二、古川良明
- Organizer
  第40回日本神経科学会大会
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] In vivo and in vitro characterization of SOD1 in early stages of ALS as a precursor to insoluble aggregates2016
- Author(s)
  Eiichi Tokuda, Itsuki Anzai, Takao Nomura, Shinji Ohara, Seiji Watanabe, Koji Yamanaka, Yuta Morisaki, Hidemi Misawa, and Yoshiaki Furukawa
- Organizer
  27th International Symposium on ALS/MND
- Place of Presentation
  Dublin (Ireland)
- Year and Date
  2016-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01566
[Presentation] 抗酸化酵素の活性発現を可能にする金属イオンの新たな獲得メカニズム2016
- Author(s)
  小久保　鉄平、櫻井　靖之、古川　良明
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  同志社大学（京都府・京田辺市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-25291028
[Presentation] Protein conformational disorder leading to neurodegenerative diseases2016
- Author(s)
  Yoshiaki Furukawa
- Organizer
  The 3rd Mini-Symposium on Cutting-Edge Chemistry
- Place of Presentation
  Hsinchu（Taiwan）
- Year and Date
  2016-03-11
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14480
[Presentation] Protein conformational disorder leading to neurodegenerative diseases2016
- Author(s)
  Yoshiaki Furukawa
- Organizer
  The 3rd Mini-Symposium on Cutting-Edge Chemistry
- Place of Presentation
  Hsinchu（Taiwan）
- Year and Date
  2016-03-11
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01566
[Presentation] A mechanism on the allosteric activation of Cu/Zn-superoxide dismutase2016
- Author(s)
  Mami Fukuoka and Yoshiaki Furukawa
- Organizer
  8th Asian Biological Inorganic Chemistry Conference
- Place of Presentation
  Auckland (New Zealand)
- Year and Date
  2016-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] 筋萎縮性側索硬化症に見られるタンパク質ミスフォールディングのメカニズム2016
- Author(s)
  古川　良明
- Organizer
  構造神経病理セミナー
- Place of Presentation
  同志社大学（京都府・京田辺市）
- Year and Date
  2016-03-25
- Invited
- Data Source
  KAKENHI-PROJECT-15K14480
[Presentation] 筋萎縮性側索硬化症に見られるタンパク質ミスフォールディングのメカニズム2016
- Author(s)
  古川　良明
- Organizer
  構造神経病理セミナー
- Place of Presentation
  同志社大学（京都府・京田辺市）
- Year and Date
  2016-03-25
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01566
[Presentation] 神経変性疾患モデルとしての線虫：In vitroからIn vivoへの橋渡し2016
- Author(s)
  古川　良明
- Organizer
  第５７回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター（兵庫県・神戸市）
- Year and Date
  2016-05-18
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01566
[Presentation] A quest for metallochaperone supplying a Zn ion to Cu/Zn-superoxide dismutase2016
- Author(s)
  Yoshiaki Furukawa
- Organizer
  第３９回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-15K14480
[Presentation] A dual role of cysteine residues in the activation of Escherichia coli Cu/Zn-superoxide dismutase2016
- Author(s)
  Yoshiaki Furukawa
- Organizer
  8th Asian Biological Inorganic Chemistry Conference
- Place of Presentation
  Auckland (New Zealand)
- Year and Date
  2016-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] A dual role of cysteine residues in the activation of Escherichia coli Cu,Zn-superoxide dismutase2016
- Author(s)
  古川　良明、小久保　鉄平、櫻井　靖之
- Organizer
  第２６回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  北海道大学（北海道・札幌市）
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] Clinical and neuropathological study of an autopsied case of familial ALS with SOD1 mutation with very long survival2016
- Author(s)
  Yo-ichi Takei, Kenya Oguchi, Takaaki Miyahira, Akiyo Hineo, Akinori Nakamura, Shinji Ohara, and Yoshiaki Furukawa
- Organizer
  The 68th Annual Meeting of the American Academy of Neurology
- Place of Presentation
  Vancouver (Canada)
- Year and Date
  2016-04-15
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01566
[Presentation] A quest for metallochaperone supplying a Zn ion to Cu/Zn-superoxide dismutase2016
- Author(s)
  Yoshiaki Furukawa
- Organizer
  第３９回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-16H04768
[Presentation] 神経変性疾患モデルの発症に関わるタンパク質コンフォメーション変化2016
- Author(s)
  古川　良明
- Organizer
  分子・物質合成プラットフォーム平成２８年度シンポジウム
- Place of Presentation
  大阪大学（大阪府・大阪市）
- Year and Date
  2016-06-17
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01566
[Presentation] 免疫化学的手法を利用した神経変性疾患関連タンパク質の構造変化解明2016
- Author(s)
  古川　良明、徳田　栄一、大原　慎司、三澤　日出巳、山中　宏二
- Organizer
  第４３回生体分子科学討論会
- Place of Presentation
  名古屋大学（愛知県・名古屋市）
- Year and Date
  2016-06-24
- Data Source
  KAKENHI-PUBLICLY-15H01566
[Presentation] 細胞内銅イオン輸送を可能にする銅シャペロンのドメイン構造2016
- Author(s)
  福岡　真実、長野　功、古川　良明
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  同志社大学（京都府・京田辺市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-25291028
[Presentation] 銅・亜鉛スーパーオキシドディスムターゼの光と影：抗酸化機能と神経変性疾患2015
- Author(s)
  古川　良明
- Organizer
  第２８回生物無機化学夏季セミナー
- Place of Presentation
  伊豆山喜旅館（静岡県・伊東市）
- Year and Date
  2015-08-28
- Invited
- Data Source
  KAKENHI-PROJECT-15K14480
[Presentation] Lost in metallation: the disaster on a protein structure leading to neurodegeneration2015
- Author(s)
  Yoshiaki Furukawa, Itsuki Anzai, Kennichi Nagasawa, Shuji Akiyama, Mizue Imai, and Koichiro Ishimori
- Organizer
  2015 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Honolulu（USA）
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01566
[Presentation] Fungal isolates with different pathotypes show distinct levels of SOD1 activity controlled by copper chaperone2015
- Author(s)
  Carolyn Lim, Yoshiyuki Usami, and Yoshiaki Furukawa
- Organizer
  The 17th International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Beijing（China）
- Year and Date
  2015-07-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25291028
[Presentation] Lights and shadows of Cu,Zn-superoxide dismutase2015
- Author(s)
  Yoshiaki Furukawa
- Organizer
  The 17th International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Beijing（China）
- Year and Date
  2015-07-20
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25291028
[Presentation] 銅・亜鉛スーパーオキシドディスムターゼの光と影：抗酸化機能と神経変性疾患2015
- Author(s)
  古川　良明
- Organizer
  第２８回生物無機化学夏季セミナー
- Place of Presentation
  伊豆山喜旅館（静岡県・伊東市）
- Year and Date
  2015-08-28
- Invited
- Data Source
  KAKENHI-PROJECT-25291028
[Presentation] Lost in metallation: the disaster on a protein structure leading to neurodegeneration2015
- Author(s)
  Yoshiaki Furukawa, Itsuki Anzai, Kennichi Nagasawa, Shuji Akiyama, Mizue Imai, and Koichiro Ishimori
- Organizer
  2015 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Honolulu（USA）
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14480
[Presentation] A new intramolecular route to acquire metal ions in superoxide dismutase2015
- Author(s)
  Teppei Kokubo, Yasuyuki Sakurai, and Yoshiaki Furukawa
- Organizer
  日本生物物理学会第53回年会
- Place of Presentation
  金沢大学（石川県・金沢市）
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-25291028
[Presentation] Lights and shadows of Cu,Zn-superoxide dismutase2015
- Author(s)
  Yoshiaki Furukawa
- Organizer
  The 17th International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Beijing（China）
- Year and Date
  2015-07-20
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01566
[Presentation] Lights and shadows of Cu,Zn-superoxide dismutase2015
- Author(s)
  Yoshiaki Furukawa
- Organizer
  The 17th International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Beijing（China）
- Year and Date
  2015-07-20
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14480
[Presentation] A new mechanism of SOD1 activation regulated by copper chaperone in Clonorchis sinensis2015
- Author(s)
  Mami Fukuoka, Isao Nagano, and Yoshiaki Furukawa
- Organizer
  日本生物物理学会第53回年会
- Place of Presentation
  金沢大学（石川県・金沢市）
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-25291028
[Presentation] Lost in metallation: the disaster on a protein structure leading to neurodegeneration2015
- Author(s)
  Yoshiaki Furukawa, Itsuki Anzai, Kennichi Nagasawa, Shuji Akiyama, Mizue Imai, and Koichiro Ishimori
- Organizer
  2015 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Honolulu（USA）
- Year and Date
  2015-12-15
- Data Source
  KAKENHI-PROJECT-25291028
[Presentation] 銅・亜鉛スーパーオキシドディスムターゼの光と影：抗酸化機能と神経変性疾患2015
- Author(s)
  古川　良明
- Organizer
  第２８回生物無機化学夏季セミナー
- Place of Presentation
  伊豆山喜旅館（静岡県・伊東市）
- Year and Date
  2015-08-28
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01566
[Presentation] A new maturation mechanism of metalloproteins regulated by formation of a disulfide bond2014
- Author(s)
  Yoshiaki Furukawa
- Organizer
  Mini Symposium in IMS
- Place of Presentation
  分子科学研究所（愛知県・岡崎市）
- Year and Date
  2014-12-17
- Invited
- Data Source
  KAKENHI-PROJECT-25291028
[Presentation] 筋萎縮性側索硬化症に見られる銅・亜鉛スーパーオキサイドディスムターゼの異常オリゴマー化とその抑制法の開発2014
- Author(s)
  安齋　樹、東一　圭祐、古川　良明
- Organizer
  日本化学会第94春季年会
- Place of Presentation
  名古屋大学東山キャンパス
- Data Source
  KAKENHI-PUBLICLY-24111542
[Presentation] 亜鉛イオンが制御する細胞内銅イオン輸送のメカニズム2014
- Author(s)
  若原　裕磨、本田　一起、古川　良明
- Organizer
  日本化学会第94春季年会
- Place of Presentation
  名古屋大学東山キャンパス
- Data Source
  KAKENHI-PROJECT-25291028
[Presentation] ジスルフィド結合が制御するSOD1タンパク質の凝集メカニズム2014
- Author(s)
  古川　良明
- Organizer
  2014 タウ研究ミーティング
- Place of Presentation
  同志社大学東京オフィス（東京都）
- Year and Date
  2014-08-01
- Invited
- Data Source
  KAKENHI-PROJECT-25291028
[Presentation] 亜鉛イオンが制御する細胞内銅イオン輸送のメカニズム2014
- Author(s)
  若原裕磨、本田一起、古川良明
- Organizer
  日本化学会第94春季年会
- Place of Presentation
  名古屋大学
- Data Source
  KAKENHI-PROJECT-24657093
[Presentation] ジスルフィド結合による銅・亜鉛スーパーオキサイドディスムターゼ活性の制御メカニズム2014
- Author(s)
  櫻井　靖之、古川　良明
- Organizer
  日本化学会第94春季年会
- Place of Presentation
  名古屋大学東山キャンパス
- Data Source
  KAKENHI-PROJECT-25291028
[Presentation] 構成論的アプローチによる生体内銅イオン輸送の制御機構解明2013
- Author(s)
  清水将裕、古川良明
- Organizer
  日本化学会第93春季年会
- Place of Presentation
  立命館大学
- Data Source
  KAKENHI-PROJECT-24657093
[Presentation] 構成論的アプローチによる生体内銅イオン輸送の制御機構解明2013
- Author(s)
  清水　将裕、古川　良明
- Organizer
  日本化学会第９３春季年会
- Place of Presentation
  立命館大学　びわこ・くさつキャンパス
- Data Source
  KAKENHI-PROJECT-24657093
[Presentation] Molecular recognition of SOD1 by its copper chaperone protein CCS: interplay of zinc ion and disulfide bond controls intracellular copper transport2013
- Author(s)
  Yoshiaki Furukawa, Kazuki Honda, and Yuma Wakahara
- Organizer
  16th International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Grenoble, France
- Data Source
  KAKENHI-PROJECT-24657093
[Presentation] 線虫モデルを利用した神経変性疾患における病態伝播のメカニズム解明2013
- Author(s)
  小川　まり子、設樂　久志、岡　浩太郎、古川　良明
- Organizer
  日本生物物理学会第51回年会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PUBLICLY-24111542
[Presentation] ジスルフィド結合形成が制御する銅シャペロンタンパク質の特異的な分子認識メカニズム2013
- Author(s)
  本田　一起、古川　良明
- Organizer
  日本化学会第９３春季年会
- Place of Presentation
  立命館大学　びわこ・くさつキャンパス
- Data Source
  KAKENHI-PROJECT-24657093
[Presentation] 亜鉛イオンが制御する銅シャペロンシステムの分子認識メカニズム2013
- Author(s)
  若原裕磨、本田一起、古川良明
- Organizer
  日本生物物理学会第51回年会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-24657093
[Presentation] ファージディスプレイ法を用いたタンパク質四次構造認識ペプチドの開発2013
- Author(s)
  野村　尚生、古川　良明
- Organizer
  日本化学会第９３春季年会
- Place of Presentation
  立命館大学　びわこ・くさつキャンパス
- Data Source
  KAKENHI-PROJECT-24657093
[Presentation] SOD1への細胞内銅イオン輸送を制御するタンパク質ネットワーク2013
- Author(s)
  中込　健太、三冨　康司、古川　良明
- Organizer
  日本生物物理学会第51回年会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-25291028
[Presentation] 構成論的アプローチによる生体内銅イオン輸送の制御機構解明2013
- Author(s)
  清水　将裕、古川　良明
- Organizer
  日本化学会第９３春季年会
- Place of Presentation
  立命館大学
- Year and Date
  2013-03-22
- Data Source
  KAKENHI-PUBLICLY-24111542
[Presentation] 銅シャペロンタンパク質CCSによるSOD1の特異的な分子認識メカニズム2013
- Author(s)
  若原裕磨、本田一起、古川良明
- Organizer
  新規素材探索研究会第12回セミナー
- Place of Presentation
  新横浜フジビューホテル
- Year and Date
  2013-06-07
- Data Source
  KAKENHI-PROJECT-24657093
[Presentation] The Activation Mechanism of Bacterial Cu,Zn-Superoxide Dismutase2013
- Author(s)
  Yasuyuki Sakurai and Yoshiaki Furukawa
- Organizer
  16th International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Grenoble, France
- Data Source
  KAKENHI-PROJECT-25291028
[Presentation] Molecular recognition of SOD1 by its copper chaperone protein CCS : interplay of zinc ion and disulfide bond controls intracellular copper transport2013
- Author(s)
  Yoshiaki Furukawa, Kazuki Honda, and Yuma Wakahara
- Organizer
  16^<th> International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Grenoble, France
- Data Source
  KAKENHI-PROJECT-24657093
[Presentation] FUS/TLSタンパク質の凝集が関与する筋萎縮性側索硬化症の新たな分子病理メカニズム2013
- Author(s)
  古川　良明、野村　尚生、渡辺　祥司、金子　貢巳、山中　宏二、貫名　信行
- Organizer
  日本生物物理学会第51回年会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PUBLICLY-24111542
[Presentation] ジスルフィド結合形成が制御する銅シャペロンタンパク質の特異的な分子認識メカニズム2013
- Author(s)
  本田一起、古川良明
- Organizer
  日本化学会第93春季年会
- Place of Presentation
  立命館大学
- Data Source
  KAKENHI-PROJECT-24657093
[Presentation] Molecular recognition of SOD1 by its copper chaperone protein CCS: interplay of zinc ion and disulfide bond controls intracellular copper transport2013
- Author(s)
  Yoshiaki Furukawa, Kazuki Honda, and Yuma Wakahara
- Organizer
  16th International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Grenoble, France
- Data Source
  KAKENHI-PROJECT-25291028
[Presentation] The Activation Mechanism of Bacterial Cu,Zn-Superoxide Dismutase2013
- Author(s)
  Yasuyuki Sakurai and Yoshiaki Furukawa
- Organizer
  16^<th> International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Grenoble, France
- Data Source
  KAKENHI-PROJECT-24657093
[Presentation] 銅シャペロンタンパク質による銅・亜鉛スーパーオキサイドディスムターゼの新たな活性化制御メカニズム2013
- Author(s)
  加藤　紗希、古川　良明
- Organizer
  日本化学会第９３春季年会
- Place of Presentation
  立命館大学　びわこ・くさつキャンパス
- Data Source
  KAKENHI-PROJECT-24657093
[Presentation] ファージディスプレイ法を用いたタンパク質四次構造認識ペプチドの開発2013
- Author(s)
  野村　尚生、古川　良明
- Organizer
  日本化学会第９３春季年会
- Place of Presentation
  立命館大学
- Year and Date
  2013-03-22
- Data Source
  KAKENHI-PUBLICLY-24111542
[Presentation] ジスルフィド結合形成が制御する銅シャペロン蛋白質の特異的な分子認識メカニズム2013
- Author(s)
  本田　一起、古川　良明
- Organizer
  日本化学会第９３春季年会
- Place of Presentation
  立命館大学
- Year and Date
  2013-03-22
- Data Source
  KAKENHI-PUBLICLY-24111542
[Presentation] 神経変性疾患における老化の役割を検証する酵母モデルの構築2013
- Author(s)
  西浦　由紘、古川　良明
- Organizer
  日本生物物理学会第51回年会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PUBLICLY-24111542
[Presentation] Neurodegeneration : Breakdown of a metal binding process in proteins2013
- Author(s)
  古川良明
- Organizer
  錯体化学会第63回討論会
- Place of Presentation
  琉球大学
- Data Source
  KAKENHI-PROJECT-24657093
[Presentation] Amyloid-like fibrillation of FUS is triggered by a pathogenic mutation in a familial form of amyotrophic lateral sclerosis2013
- Author(s)
  古川　良明、野村　尚生、渡辺　祥司、金子　貢巳、山中　宏二、貫名　信行
- Organizer
  第36回日本神経科学大会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PUBLICLY-24111542
[Presentation] Neurodegeneration: Breakdown of a metal binding process in proteins2013
- Author(s)
  古川　良明
- Organizer
  錯体化学会第63回討論会
- Place of Presentation
  琉球大学
- Invited
- Data Source
  KAKENHI-PROJECT-24657093
[Presentation] 銅シャペロンタンパク質による銅・亜鉛スーパーオキシドディスムターゼの新たな活性化制御メカニズム2013
- Author(s)
  加藤　紗希、古川　良明
- Organizer
  日本化学会第９３春季年会
- Place of Presentation
  立命館大学
- Year and Date
  2013-03-22
- Data Source
  KAKENHI-PUBLICLY-24111542
[Presentation] SOD1への細胞内銅イオン輸送を制御するタンパク質ネットワーク2013
- Author(s)
  中込健太、三冨康司、古川良明
- Organizer
  日本生物物理学会第51回年会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-24657093
[Presentation] The Activation Mechanism of Bacterial Cu,Zn-Superoxide Dismutase2013
- Author(s)
  Yasuyuki Sakurai and Yoshiaki Furukawa
- Organizer
  16th International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Grenoble, France
- Data Source
  KAKENHI-PROJECT-24657093
[Presentation] A new molecular mechanism describing the formation of disulfide cross-linked SOD1 in the familial form of amyotrophic lateral sclerosis2012
- Author(s)
  Keisuke Toichi, Koji Yamanaka, Yoshiaki Furukawa
- Organizer
  23rd International Symposium on ALS/MND
- Place of Presentation
  Chicago, USA
- Year and Date
  2012-12-05
- Data Source
  KAKENHI-PUBLICLY-24111542
[Presentation] Redox environment is an intracellular factor to operate distinct pathways for protein aggregation2012
- Author(s)
  古川　良明
- Organizer
  日本生物物理学会第５０回年会
- Place of Presentation
  名古屋大学
- Year and Date
  2012-09-22
- Data Source
  KAKENHI-PUBLICLY-24111542
[Presentation] Destabilization of SOD1 facilitates abnormal scrambling of its disulfide bond in the familial form of amyotrophic lateral sclerosis2012
- Author(s)
  東一　圭祐、古川　良明
- Organizer
  日本生物物理学会第５０回年会
- Place of Presentation
  名古屋大学
- Year and Date
  2012-09-22
- Data Source
  KAKENHI-PUBLICLY-24111542
[Presentation] タンパク質の線維化による神経変性疾患ALSの病態制御メカニズム2012
- Author(s)
  古川良明
- Organizer
  先端融合科学シンポジウム「タンパク質アセンブリ-会合、超分子化、凝集-」
- Place of Presentation
  神戸大学・六甲台キャンパス
- Year and Date
  2012-02-01
- Data Source
  KAKENHI-PROJECT-22770162
[Presentation] タンパク質の線維化による神経変性疾患ALSの病態制御メカニズム2012
- Author(s)
  古川良明
- Organizer
  先端融合科学シンポジウム「タンパク質アセンブリ-会合、超分子化、凝集-」
- Place of Presentation
  神戸大学・六甲台キャンパス(招待講演)
- Year and Date
  2012-02-01
- Data Source
  KAKENHI-PROJECT-22770162
[Presentation] A new molecular mechanism describing the formation of disulfide cross-linked SOD1 in the familial form of amyotrophic lateral sclerosis2012
- Author(s)
  Keisuke Toichi, Koji Yamanaka, Yoshiaki Furukawa
- Organizer
  23rd International Symposium on ALS/MND
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-24657093
[Presentation] A mechanism controlling the morphologies of protein aggregates by "post-aggregation oxidation"2012
- Author(s)
  三冨　康司、古川　良明
- Organizer
  日本生物物理学会第５０回年会
- Place of Presentation
  名古屋大学
- Year and Date
  2012-09-22
- Data Source
  KAKENHI-PUBLICLY-24111542
[Presentation] 金属シャペロンCCSによるSOD1の特異的な分子認識メカニズム2012
- Author(s)
  本田一起、古川良明
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-24657093
[Presentation] Oligomerization mechanism of SOD1 regulated by disulfide scrambling in the familial form of ALS2012
- Author(s)
  古川　良明、東一　圭祐、山中　宏二
- Organizer
  第３５回日本神経科学会大会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2012-09-18
- Data Source
  KAKENHI-PUBLICLY-24111542
[Presentation] A Seeded Aggregation of TDP-43 Reproduces the Intracellular Formation of Sarkosyl-Insoluble Inclusions2011
- Author(s)
  Yoshiaki Furukawa, Kumi Kaneko, Shoji Watanabe, Koji Yamanaka, and Nobuyuki Nukina
- Organizer
  22^<nd> International Symposium on ALS/MND
- Place of Presentation
  シドニー(オーストラリア)
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-22770162
[Presentation] A thiol-disulfide status in SOD1 controls distinct pathways for aggregate formation in amyotrophic lateral sclerosis2011
- Author(s)
  東一圭祐、古川良明
- Organizer
  日本生物物理学会第49回年会
- Place of Presentation
  兵庫県立大学・姫路書写キャンパス
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-22770162
[Presentation] A Seeded Aggregation of TDP-43 Reproduces the Intracellular Formation of Sarkosyl-Insoluble Inclusions2011
- Author(s)
  Yoshiaki Furukawa, Kumi Kaneko, Shoji Watanabe, Koji Yamanaka, Nukina Nobuyuki
- Organizer
  22^<nd> International Symposium on ALS/MND
- Place of Presentation
  Sydney, Australia
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-22770162
[Presentation] Polymorphism of protein aggregates produced by genetic and chemical modifications2011
- Author(s)
  古川良明
- Organizer
  日本生物物理学会第49回年会
- Place of Presentation
  兵庫県立大学・姫路書写キャンパス(招待講演)
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-22770162
[Presentation] タウが形成するジスルフィド結合依存的な線維構造とその多型発現のメカニズム2011
- Author(s)
  古川良明、金子貢巳、貫名信行
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  ホテル阪急エキスポパーク
- Year and Date
  2011-06-07
- Data Source
  KAKENHI-PROJECT-22770162
[Presentation] Morphological and Biochemical Properties of Protein Aggregates Controlled by "Post-aggregation Modifications"2011
- Author(s)
  三冨康司、古川良明
- Organizer
  日本生物物理学会第49回年会
- Place of Presentation
  兵庫県立大学・姫路書写キャンパス
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-22770162
[Presentation] Polymorphism of Protein Aggregates Produced by Genetic and Chemical Modifications2011
- Author(s)
  古川良明
- Organizer
  日本生物物理学会第49回年会
- Place of Presentation
  兵庫県立大学・姫路書写キャンパス
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-22770162
[Presentation] A Thiol-disulfide Status in SOD1 Controls Distinct Pathways for Aggregate Formation in Amyotrophic Lateral Sclerosis2011
- Author(s)
  東一圭祐、古川良明
- Organizer
  日本生物物理学会第49回年会
- Place of Presentation
  兵庫県立大学・姫路書写キャンパス
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-22770162
[Presentation] Morphological and biochemical properties of protein aggregates controlled by "post-aggregation modifications"2011
- Author(s)
  三冨康司、古川良明
- Organizer
  日本生物物理学会第49回年会
- Place of Presentation
  兵庫県立大学・姫路書写キャンパス
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-22770162
[Presentation] Structural polymorphism of Cu,Zn-superoxide dismutase aggregates in the familial form of amyotrophic lateral sclerosis2010
- Author(s)
  Yoshiaki Furukawa, et al.
- Organizer
  2010 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Honolulu convention center, Hawaii
- Year and Date
  2010-12-16
- Data Source
  KAKENHI-PROJECT-22770162
[Presentation] 筋萎縮性側索硬化症に見られるTDP-43の細胞内凝集モデル構築2010
- Author(s)
  古川良明、金子貢巳、渡辺祥司、山中宏二、貫名信行
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-22770162
[Presentation] タンパク質線維化の分子制御メカニズム2010
- Author(s)
  古川良明
- Organizer
  包括型脳科学研究推進支援ネットワーク
- Place of Presentation
  ホテルさっぽろ芸文館
- Year and Date
  2010-07-30
- Data Source
  KAKENHI-PROJECT-22770162
[Presentation] Structural polymorphism of protein aggregates and its pathological relevance2010
- Author(s)
  古川良明、金子貢巳、山中宏二、貫名信行
- Organizer
  日本生物物理学会第48回年会
- Place of Presentation
  東北大学川内北キャンパス
- Year and Date
  2010-09-20
- Data Source
  KAKENHI-PROJECT-22770162
[Presentation] ポリグルタミン病の新たな分子病理メカニズム-タンパク質線維の構造伝播による発症制御の可能性2009
- Author(s)
  古川良明
- Organizer
  日本生物物理学会第47回年会
- Place of Presentation
  徳島文理大学
- Data Source
  KAKENHI-PROJECT-20770130
[Presentation] SOD1 Fibrillation Mechanism Relevant to Familial Form of ALS - Molecular Dissection of Mutation-dependent Pathogenisity2009
- Author(s)
  Yoshiaki Furukawa, Kumi Kaneko, Nobuyuki Nukina
- Organizer
  14th International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Nagoya, Japan
- Data Source
  KAKENHI-PROJECT-20770130
[Presentation] SOD1 Fibrillation Mechanism Relevant to Familial Form of ALS2009
- Author(s)
  古川良明、金子貢巳、貫名信行
- Organizer
  20^<th> International Symposium on ALS/MND
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-20770130
[Presentation] ポリグルタミン病の新たな分子病理メカニズム-タンパク質線維の構造伝播による発症制御の可能性2009
- Author(s)
  古川良明
- Organizer
  第47回日本生物物理学会年会
- Place of Presentation
  徳島市
- Data Source
  KAKENHI-PROJECT-20770130
[Presentation] 翻訳後修飾が制御する蛋白質凝集の分子メカニズム2009
- Author(s)
  古川良明
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20770130
[Presentation] SOD1 Fibrillation Mechanism Relevant to Familial Form of ALS-Molecular Dissection of Mutation-dependent Pathogenisity2009
- Author(s)
  古川良明、金子貢巳、貫名信行
- Organizer
  14^<th> International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Nagoya, Japan
- Data Source
  KAKENHI-PROJECT-20770130
[Presentation] 翻訳後修飾が制御するSOD1蛋白質の線維化と筋萎縮性側索硬化症2009
- Author(s)
  古川良明、金子貢巳、貫名信行
- Organizer
  第36回生体分子科学討論会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20770130
[Presentation] 翻訳後修飾が制御するSOD1蛋白質の線維化と筋萎縮性側索硬化症2009
- Author(s)
  古川良明、金子貢巳、貫名信行
- Organizer
  第36回生体分子科学討論会
- Place of Presentation
  北海道大学学術交流会館
- Data Source
  KAKENHI-PROJECT-20770130
[Presentation] SOD1 Fibrillation Mechanism Relevant to Familial Form of ALS2009
- Author(s)
  Yoshiaki Furukawa, Kumi Kaneko, Nobuyuki Nukina
- Organizer
  20th International Symposium on ALS/MND
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-20770130
[Presentation] 翻訳後修飾が制御する蛋白質凝集の分子メカニズム2009
- Author(s)
  古川良明
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-20770130
[Presentation] Cross-seeded Fibrillization Describes Recruitment of RNA-binding Protein into Polyglutamine Aggregates2008
- Author(s)
  Yoshiaki Furukawa, Kumi Kaneko, Gen Matsumoto, Masaru Kurosawa, Nobuyuki Nukina
- Organizer
  第31回日本神経科学会年会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-20770130
[Presentation] Cross-seeded Fibrillization Describes Recruitment of RNA-binding Protein into Polyglutamine Aggregates2008
- Author(s)
  古川良明
- Organizer
  第31回日本神経料学会年会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2008-07-09
- Data Source
  KAKENHI-PROJECT-20770130
[Presentation] Molecular dissection of SOD1 aggregation and its structural rationale2008
- Author(s)
  古川良明、金子貢巳、貫名信行
- Organizer
  日本生物物理学会第46回年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-20770130
[Presentation] 神経変性疾患におけるSOD1蛋白質の成熟化と凝集制御のメカニズム2008
- Author(s)
  古川良明
- Organizer
  第8回日本蛋白質科学会年会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-20770130
[Presentation] 神経変性疾患におけるSOD1蛋白質の成熟化と凝集制御のメカニズム2008
- Author(s)
  古川良明
- Organizer
  第8回日本蛋白質料学会年会
- Place of Presentation
  タワーホール船堀
- Year and Date
  2008-06-12
- Data Source
  KAKENHI-PROJECT-20770130
[Presentation] Complete loss of post-translational modifications triggers fibrillar aggreg ation of SOD1 in familial form of ALS2007
- Author(s)
  古川良明、金子貢巳、山中宏二、貫名信行
- Organizer
  第67回岡崎カンファレンス
- Place of Presentation
  岡崎カンファレンスセンター
- Data Source
  KAKENHI-PROJECT-18031044
[Presentation] 家族性ALSに見られるSOD1蛋白質のアミロイド形成と翻訳後修飾過程による制御メカニズム2007
- Author(s)
  古川良明、金子貢巳、山中宏二、貫名信行
- Organizer
  日本生物物理学会第45回年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-18031044
[Presentation] Complete loss of post-translational modifications triggers fibrillar aggregation of SOD1 in familial form of ALS2007
- Author(s)
  古川良明、金子貢巳、山中宏二、貫名信行
- Organizer
  第67回岡崎カンファレンス
- Place of Presentation
  岡崎カンファレンスセンター
- Data Source
  KAKENHI-PROJECT-18770143
[Presentation] 家族性ALSに見られるSOD1蛋白質のアミロイド形成と翻訳後修飾過程による制御メカニズム2007
- Author(s)
  古川良明、金子貢巳、山中宏二、貫名信行
- Organizer
  日本生物物理学会第45回年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-18770143
[Presentation] 筋萎縮性側索硬化症に見られるSOD1蛋白質の凝集化機構2007
- Author(s)
  古川良明
- Organizer
  大阪大学蛋白質研究所セミナー
- Place of Presentation
  大阪大学蛋白質研究所
- Data Source
  KAKENHI-PROJECT-18031044
[Presentation] 筋萎縮性側索硬化症に見られるSOD1蛋白質の凝集化機構2007
- Author(s)
  古川良明
- Organizer
  大阪大学蛋白質研究所セミナー
- Place of Presentation
  大阪大学蛋白質研究所
- Data Source
  KAKENHI-PROJECT-18770143
[Presentation] Disulfide formation acts as a redox sensor for enzymatic activation of Cu,Zn-superoxide dismutase
- Author(s)
  Yoshiaki Furukawa
- Organizer
  7th Asian Biological Inorganic Chemistry Conference
- Place of Presentation
  Gold Coast (Australia)
- Year and Date
  2014-11-30 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-25291028
[Presentation] タンパク質の凝集に関わる実験的諸問題について
- Author(s)
  古川　良明
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  ワークピア横浜（神奈川県・横浜市）
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25291028
[Presentation] A molecular mechanism of bacterial superoxide dismutase regulated by disulfide formation
- Author(s)
  Yoshiaki Furukawa
- Organizer
  The 7th Korea-Japan Seminars on Biomolecular Sciences: Experiments and Simulations
- Place of Presentation
  Seoul (South Korea)
- Year and Date
  2014-11-26 – 2014-11-28
- Invited
- Data Source
  KAKENHI-PROJECT-25291028
[Presentation] An activation mechanism of human Cu,Zn-superoxide dismutase by its copper chaperone, CCS
- Author(s)
  Carolyn Lim and Yoshiaki Furukawa
- Organizer
  日本生物物理学会第52回年会
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25291028
[Presentation] タンパク質ジスルフィドの異常が神経変性疾患の発症に果たす役割：線虫を用いた表現型解析
- Author(s)
  小川　まり子、設樂　久志、岡　浩太郎、古川　良明
- Organizer
  日本生物物理学会第52回年会
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25291028
[Presentation] Molecular recognition in copper chaperone system is regulated by Zn ion
- Author(s)
  Yuma Wakahara and Yoshiaki Furukawa
- Organizer
  7th Asian Biological Inorganic Chemistry Conference
- Place of Presentation
  Gold Coast (Australia)
- Year and Date
  2014-11-30 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-25291028
[Presentation] ジスルフィド結合のシャッフリングを標的とした異常なタンパク質オリゴマー化の抑制手法
- Author(s)
  安齋　樹、東一　圭祐、向山　厚、秋山　修志、古川　良明
- Organizer
  日本生物物理学会第52回年会
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25291028

1. NOMURA Takao (90597840)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. Tsumoto Kouhei (90271866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 石森浩一郎 (20192487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 小椋康光 (40292677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 青野重利 (60183729)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 城宜嗣 (70183051)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 高野順平 (70532472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 神戸大朋 (90303875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. IMAMURA Yukio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 山中智行

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
11. 貫名信行

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
12. 徳田栄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 守村敏史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 下郡智美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 三澤日出巳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 山中宏二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 渡邊征爾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 奥住文美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 鎌足雄司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 神志那弘明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 村木則文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Furukawa Yoshiaki 古川 良明

FURUKAWA Yoshiaki 古川 良明

Research Projects

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Co-Researchers

超硫黄化による銅シャペロン保護メカニズムの解明Principal Investigator

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神経変性疾患の早期診断を指向した構造異常型タンパク質の極微量検出Principal Investigator

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加齢に伴うタンパク質の構造・機能変化とその病理学的役割の解明Principal Investigator

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Detection of misfolded Cu/Zn-superoxide dismutase proteins with Caenorhabditis elegansPrincipal Investigator

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Integrated Biometal Science: Research to Explore Dynamics of Metals in Cellular System

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生命金属動態を制御するシャペロン分子ネットワークの解明Principal Investigator

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分子夾雑環境におけるタンパク質の金属イオン獲得メカニズムPrincipal Investigator

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異常構造型脳タンパク質の経口摂取による神経変性疾患発症の可能性Principal Investigator

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Understanding a mechanism regulating intracellular dynamics of metal ionsPrincipal Investigator

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Identification of intracellular zinc chaperonesPrincipal Investigator

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脳タンパク質老化の伝播性と感染性を検証する線虫モデルの確立Principal Investigator

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A mechanism regulating the copper acquisition by intracellular proteinsPrincipal Investigator

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シーディングによる脳内環境の破綻伝播メカニズムの解明Principal Investigator

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Furukawa Yoshiaki 古川良明

FURUKAWA Yoshiaki 古川良明