OSAJIMA Yuko 筬島裕子

Researcher Number	40451934
Affiliation (based on the past Project Information) *help	2011 – 2012: Tokyo Medical and Dental University, 医学部附属病院, その他 2010: 東京医科歯科大学, 医学部附属病院, 医員 2008: 東京医科歯科大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology
Keywords	Principal Investigator RNAポリメラーゼ / 細胞障害効果 / プラークアッセイ / HCV-JFH1培養系 Except Principal Investigator HVC-JFH1培養系 / HCV-JFH1培養系 / HCVレプリコン

細胞障害性HCV培養系を用いた重症C型肝炎発症機構の解析Principal Investigator
- Principal Investigator
  
  筬島裕子
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Search for new classes of HCV therapeutics by large scale screening of antiviral compounds and host cellular factors
- Principal Investigator
  
  SAKAMOTO Naoya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University

All 2009 2008 2007

All Journal Article Presentation

[Journal Article] Two flavonoids extracts from a herb, Glycyrrhizae radix, inhibit in-vitro hepatitis C virus replication.2009
- Author(s)
  Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Suda G, Mishima K, Onuki Y, Yamamoto M, Maekawa S, Enomoto N, Kanai T, Tsuchiya K, Watanabe M
- Journal Title
  
  Hepatoloj Res 39
  
  Pages: 60-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Two flavonoids extracts from a herb, Glycyrrhizae radix, inhibit in-vitro hepatitis C virus replication2009
- Author(s)
  Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Suda G, Mishima K, Onuki Y, Yamamoto M, Maekawa S, Enomoto N, Kanai T, Tsuchiya K, Watanabe M
- Journal Title
  
  Hepatology Res 39(1)
  
  Pages: 60-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Two flavonoids extracts from a herb, Glycyrrhizae radix, inhibit in-vitrohepatitis C virus replication.2008
- Author(s)
  Sakamoto N, Sekine-Osajima Y, Nakagawa M, Itsui Y, Chen CH, Watanabe M, et. al.
- Journal Title
  
  Hepatology Research (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Development of plaque assays for hepatitis C virus and isolation of mutants with enhanced cytopathogenicity and replication capacity.2008
- Author(s)
  Sekine-Osajima Y, Sakamoto N (equal contribution), Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Kanai T, Tsuchiya K, Wakita T, Enomoto N, Watanabe M
- Journal Title
  
  Virology 368
  
  Pages: 71-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Development of plaque assaysfor hepatitis C virus and isolation of mutantswith enhanced cytopathogenicity and replication capacity2008
- Author(s)
  Sekine-Osajima Y, Sakamoto N(equal contribution), Nakagawa M, Itsui Y, TasakaM, Nishimura-Sakurai Y, Chen CH, Kanai T,Tsuchiya K, Wakita T, Enomoto N and Watanabe M
- Journal Title
  
  Virology 371
  
  Pages: 71-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA.2008
- Author(s)
  Sakamoto N, Tanabe Y, Yokota T, Saito K, Sekine-Osajima Y, Nakagawa M, Itsui Y, Tasaka M, Sakurai Y, Chen CH, Yano M, Ohkoshi S, Aoyagi Y, Maekawa S, Enomoto N, Kohara M, Watanabe M
- Journal Title
  
  J Gastro Hepatol 23
  
  Pages: 1437-1447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA2008
- Author(s)
  Sakamoto N, Tanabe Y, Yokota T, Saito K,Sekine-Osajima Y, Nakagawa M, Itsui Y,Tasaka M, Sakurai Y, Chen CH, Yano M,Ohkoshi S, Aoyagi Y, Maekawa S, Enomoto N, Kohara M, Watanabe M
- Journal Title
  
  J Gastro Hepatol 23(9)
  
  Pages: 1437-1447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Bone morphogenetic protein-7 and interferon-alpha synergistically suppress hepatitis C virus replicon2007
- Author(s)
  Sakamoto N, Yoshimura M, Kimura T, Toyama K, Sekine-Osajima Y, Watanabe M, Muramatsu M
- Journal Title
  
  Biochem Biophys Res Commun 357
  
  Pages: 467-473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] HCV nonstructural proteins responsible for suppression of RIG-I/Cardif-induced interferon response2007
- Author(s)
  Tasaka M, Sakamoto N(equal contribution), Itakura Y, Nakagawa M, Itusi Y,Sekine-Osajima Y, Nishimura-Sakurai Y,Chen CH, Yoneyama M, Fujita T, Wakita T,Maekawa S, Enomoto N, Watanabe M
- Journal Title
  
  J Gen Virol 88
  
  Pages: 3323-3333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] Establishment and genetic analyses of cytopathogenic HCV-JFH1 mutants by plaque-forming assay2008
- Author(s)
  Naoya Sakamoto, Kako Mishima, YukoSekine-Osajima, Mina Nakagawa, MegumiTasaka, Yuki Nishimura-Sakurai, YasuhiroItsui, Takaji Wakita,and Mamoru Watanabe
- Organizer
  15th. International Meeting on Hepatitis C Virus & RelatedViruses
- Place of Presentation
  San Antonio, TX
- Year and Date
  2008-10-04
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] Establishment and genetic analyzes of cytopathogenic HCV-JFH1 mutants by plaque-forming assay.2008
- Author(s)
  Kako Mishima, Naoya Sakamoto. Yuko Sekine-Osajima, Mina Nakagawa, Megumi Tasaka, Yuki Nishimura-Sakurai, Yasuhiro Itsui, Takaji Wakita, Mamoru Watanabe
- Organizer
  Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] Establishment and genetic analyzes of cytopathogenic HCV-JFHI mutants by plaque-forming assay.2008
- Author(s)
  Naoya Sakamoto, Kako Mishima, Yuko Sekine-Osajima, Mina Nakagawa, Megumi Tasaka, Yuki Nishimura-Sakurai, Yasuhiro Itsui, Takaji Wakita, Mamoru Watanabe
- Organizer
  15th. International Meeting on Hepatitis C Virus & Related Viruses.
- Place of Presentation
  San Antonio, TX, USA
- Year and Date
  2008-10-04
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] Establishment and genetic analyses of cytopatho genic HCV-JFH1 mutants by plaque-forming assay2008
- Author(s)
  Kako Mishima, Naoya Sakamoto, YukoSekine-Osajima, Mina Nakagawa, MegumiTasaka, Yuki Nishimura-Sakurai, YasuhiroItsui, Takaji Wakita,and Mamoru Watanabe
- Organizer
  Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco,CA
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] Development of plaque-forming assays for hepatitis C virus and isolation of mutants with enhanced cytopathogenicity and replication capacity2007
- Author(s)
  Naoya Sakamoto, Yuko Sekine-Osajima, Kako Mishima, Mina Nakagawa, Megumi Tasaka, Yuki Nishimura-Sakurai, Yasuhiro Itsui, Takaji Wakita,and Mamoru Watanabe
- Organizer
  14th. International Meeting on Hepatitis C Virus & Related Viruses
- Place of Presentation
  Glasgow, UK
- Year and Date
  2007-09-09
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] Plaque-forming assays for hepatitis C virus and isolation of HCV-JFH1 mutants with enhanced cytopathogenicity and replication capacity2007
- Author(s)
  Naoya Sakamoto, Yuko Sekine-Osajima, Kako Mishima, Mina Nakagawa, Megumi Tasaka, Yuki Nishimura-Sakurai, YasuhiroItsui, Takaji Wakita,and Mamoru Watanabe
- Organizer
  Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Boston, MA
- Year and Date
  2007-10-31
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] Antiviral effects of interferon-induced proteins, GBP-1, IFI6-16 and IFI27 and their interactions with hepatitis C virus nonstructural proteins2007
- Author(s)
  Yasuhiro Itsui, Naoya Sakamoto, Mina Nakagawa, Yuko Sekine-Osajima, Megumi Tasaka,and Mamoru Watanabe
- Organizer
  Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Boston, MA
- Year and Date
  2007-10-31
- Data Source
  KAKENHI-PROJECT-19390196

1. SAKAMOTO Naoya (10334418)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
2. WATANABE Mamoru (10175127)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
3. CHEN Cheng-hsin (10376783)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. NAKAGAWA Mina (30401342)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
5. ITSUI Yasuhiro (20401341)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
6. KAKINUMA Sei (30372444)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. TASAKA Megumi (50510369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
8. 櫻井幸 (70547455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OSAJIMA Yuko 筬島 裕子

Research Projects

Research Products

Co-Researchers

細胞障害性HCV培養系を用いた重症C型肝炎発症機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Search for new classes of HCV therapeutics by large scale screening of antiviral compounds and host cellular factors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Two flavonoids extracts from a herb, Glycyrrhizae radix, inhibit in-vitro hepatitis C virus replication.2009

Author(s)

Journal Title

Data Source

[Journal Article] Two flavonoids extracts from a herb, Glycyrrhizae radix, inhibit in-vitro hepatitis C virus replication2009

Author(s)

Journal Title

Data Source

[Journal Article] Two flavonoids extracts from a herb, Glycyrrhizae radix, inhibit in-vitrohepatitis C virus replication.2008

Author(s)

Journal Title

Data Source

[Journal Article] Development of plaque assays for hepatitis C virus and isolation of mutants with enhanced cytopathogenicity and replication capacity.2008

Author(s)

Journal Title

Data Source

[Journal Article] Development of plaque assaysfor hepatitis C virus and isolation of mutantswith enhanced cytopathogenicity and replication capacity2008

Author(s)

Journal Title

Data Source

[Journal Article] Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA.2008

Author(s)

Journal Title

Data Source

[Journal Article] Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA2008

Author(s)

Journal Title

Data Source

[Journal Article] Bone morphogenetic protein-7 and interferon-alpha synergistically suppress hepatitis C virus replicon2007

Author(s)

Journal Title

Data Source

[Journal Article] HCV nonstructural proteins responsible for suppression of RIG-I/Cardif-induced interferon response2007

Author(s)

Journal Title

Data Source

[Presentation] Establishment and genetic analyses of cytopathogenic HCV-JFH1 mutants by plaque-forming assay2008

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Establishment and genetic analyzes of cytopathogenic HCV-JFH1 mutants by plaque-forming assay.2008

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Establishment and genetic analyzes of cytopathogenic HCV-JFHI mutants by plaque-forming assay.2008

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Establishment and genetic analyses of cytopatho genic HCV-JFH1 mutants by plaque-forming assay2008

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Development of plaque-forming assays for hepatitis C virus and isolation of mutants with enhanced cytopathogenicity and replication capacity2007

Author(s)

Organizer

Place of Presentation

OSAJIMA Yuko 筬島裕子