FUJIKI Fumihiro 藤木文博

… Alternative Names

藤木文博フジキフミヒロ

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Researcher Number	40456926
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 寄附講座准教授
Affiliation (based on the past Project Information) *help	2025: 大阪大学, 大学院医学系研究科, 招へい准教授 2021 – 2024: 大阪大学, 大学院医学系研究科, 寄附講座准教授 2021: 大阪大学, 医学(系)研究科(研究院), 准教授 2017 – 2019: 大阪大学, 医学系研究科, 特任准教授(常勤) 2016: 大阪大学, 医学系研究科, 特任助教(常勤) … More 2015: 大阪大学, 医学(系)研究科(研究院), 招聘教員 2014: 大阪大学, 医学(系)研究科(研究院), 助教 2013: 大阪大学, 医学(系)研究科(研究院), 特任助教 2013: 大阪大学, 医学(系)研究科(研究院), 特任助教(常勤) 2012: 大阪大学, 医学(系)研究科(研究院), 特任助教 (常勤) 2011: 大阪大学, 大学院・医学系研究科, 特任助教(常勤) 2009 – 2011: 大阪大学, 医学系研究科, 特任助教(常勤) 2009: 大阪大学, 大学院・医学系研究科, 特任助教(常勤) Less
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor therapeutics / Tumor immunology Except Principal Investigator Biological Sciences
Keywords	Principal Investigator 癌免疫療法 / メモリーT細胞 / 疲弊T細胞 / がん免疫療法 / 腫瘍免疫 / マスター遺伝子 / WT1 / ヘルパーT細胞 / CRISPR / CRISPR-gRNA library … More / CRISPR gRNA library / TCF-1 / CRISPR gRNA / CRISPR-Cas9 / 癌免疫 / CRISPRライブラリ / T細胞 / CRISPR Library / LCMV慢性感染症 / LCMV / 癌 / 免疫学 / ターミナルエフェクターT細胞 / ターミナルエフェクター / エフェクターーＴ細胞 / メモリーＴ細胞 / ヘルパーＴ細胞 / CTL / CD4+ヘルパーT細胞 / エフェクターT細胞 … More Except Principal Investigator 免疫学 / 癌 / 遺伝子 / 免役療法 / 分子標的治療法 / 分子標的治療 / 免疫療法 / 分子標的療法 / 分子診断 / 白血病 / WT1 Less

LCMV慢性感染症モデルにおける疲弊T細胞の克服と癌免疫療法への応用Principal Investigator
- Principal Investigator
  
  藤木文博
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  The University of Osaka
Overcoming T cell exhaustion in chronic LCMV infection model and its application to cancer immunotherapyPrincipal Investigator
- Principal Investigator
  
  藤木文博
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Osaka University
網羅的遺伝子ノックアウト技術を活用した新規がんー免疫チェックポイント標的薬の創製Principal Investigator
- Principal Investigator
  
  藤木文博
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Osaka University
Elucidation of molecular mechanism of T cell terminal differentiation lineage for cancer immunotherapyPrincipal Investigator
- Principal Investigator
  
  Fujiki Fumihiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Osaka University
A novel pathway regulating memory T cell development for cancer immunotherapyPrincipal Investigator
- Principal Investigator
  
  Fujiki Fumihiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Osaka University
Development of a novel cancer immunotherapy based on efficient induction of memory T cells.Principal Investigator
- Principal Investigator
  
  FUJIKI Fumihiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor immunology
- Research Institution
  Osaka University
Identification of novel master gene controlling memory CD4+ T cell for improving cancer immunotherapyPrincipal Investigator
- Principal Investigator
  
  FUJIKI Fumihiro
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor immunology
- Research Institution
  Osaka University
Development of molecular diagnosis and molecule-targeted therapy for leukemia
- Principal Investigator
  
  SUGIYAMA Haruo
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University

[Journal Article] Establishment of a novel NFAT-GFP reporter platform useful for the functional avidity maturation of HLA class II-restricted TCRs2023
- Author(s)
  Fujiki Fumihiro、Morimoto Soyoko、Nishida Yuya、Tanii Satoe、Aoyama Nao、Inatome Miki、Inoue Kento、Katsuhara Akiko、Nakajima Hiroko、Nakata Jun、Nishida Sumiyuki、Tsuboi Akihiro、Oka Yoshihiro、Oji Yusuke、Sogo Shinji、Sugiyama Haruo
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: in press Issue: 7 Pages: 2347-2356
- DOI
  10.1007/s00262-023-03420-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07251, KAKENHI-PROJECT-23K06761, KAKENHI-PROJECT-23K21389
[Journal Article] T Cell-Intrinsic Vitamin A Metabolism and Its Signaling Are Targets for Memory T Cell-Based Cancer Immunotherapy2022
- Author(s)
  Fujiki Fumihiro、Morimoto Soyoko、Katsuhara Akiko、Okuda Akane、Ogawa Saeka、Ueda Eriko、Miyazaki Maki、Isotani Ayako、Ikawa Masahito、Nishida Sumiyuki、Nakajima Hiroko、Tsuboi Akihiro、Oka Yoshihiro、Nakata Jun、Hosen Naoki、Kumanogoh Atsushi、Oji Yusuke、Sugiyama Haruo
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 935465-935465
- DOI
  10.3389/fimmu.2022.935465
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07251, KAKENHI-PROJECT-23K21389
[Journal Article] Reader-free ELISPOT assay for immuno-monitoring in peptide-based cancer vaccine immunotherapy2020
- Author(s)
  Hayashi Sae、Imanishi Rin、Adachi Mayuko、Ikejima Sayaka、Nakata Jun、Morimoto Soyoko、Fujiki Fumihiro、Nishida Sumiyuki、Tsuboi Akihiro、Hosen Naoki、Nakajima Hiroko、Hasegawa Kana、Oka Yoshihiro、Sugiyama Haruo、Oji Yusuke
- Journal Title
  
  Biomedical Reports
  
  Volume: 12 Pages: 244-250
- DOI
  10.3892/br.2020.1289
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07215, KAKENHI-PROJECT-20K07695
[Journal Article] Immune adjuvant therapy using Bacillus Calmette-Guérin cell wall skeleton (BCG-CWS) in advanced malignancies: A phase 1 study of safety and immunogenicity assessments.2019
- Author(s)
  Nishida S, Tsuboi A, Tanemura A, Ito T, Nakajima H, Shirakata T, Morimoto S, Fujiki F, Hosen N, Oji Y, Kumanogoh A, Kawase I, Oka Y, Azuma I, Morita S, Sugiyama H.
- Journal Title
  
  Medicine (Baltimore)
  
  Volume: 98 Issue: 33 Pages: e16771-e16771
- DOI
  10.1097/md.0000000000016771
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07729, KAKENHI-PROJECT-17K07215, KAKENHI-PROJECT-17K07216
[Journal Article] Combination Gemcitabine and WT1 Peptide Vaccination Improves Progression-Free Survival in Advanced Pancreatic Ductal Adenocarcinoma: A Phase II Randomized Study.2018
- Author(s)
  Nishida S, Ishikawa T, Egawa S, Koido S, Yanagimoto H, Ishii J, Kanno Y, Kokura S, Yasuda H, Oba MS, Sato M, Morimoto S, Fujiki F, Eguchi H, Nagano H, Kumanogoh A, Unno M, Kon M, Shimada H, Ito K, Homma S, Oka Y, Morita S, Sugiyama H.
- Journal Title
  
  Cancer Immunol Res.
  
  Volume: 6 Issue: 3 Pages: 320-331
- DOI
  10.1158/2326-6066.cir-17-0386
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11136, KAKENHI-PROJECT-17K07215, KAKENHI-PROJECT-17K07216, KAKENHI-PROJECT-15K09050, KAKENHI-PROJECT-15K09173
[Journal Article] Extremely strong infiltration of WT1-specific CTLs into mouse tumor by the combination vaccine with WT1-specific CTL and helper peptides2018
- Author(s)
  Nakata Jun、Nakajima Hiroko、Hayashibara Hiromu、Imafuku Kanako、Morimoto Soyoko、Fujiki Fumihiro、Motooka Daisuke、Okuzaki Daisuke、Hasegawa Kana、Hosen Naoki、Tsuboi Akihiro、Oka Yoshihiro、Kumanogoh Atsushi、Oji Yusuke、Sugiyama Haruo
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 89 Pages: 36029-36038
- DOI
  10.18632/oncotarget.26338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07215
[Journal Article] A phase I clinical study of a cocktail vaccine of Wilms’ tumor 1 (WT1) HLA class I and II peptides for recurrent malignant glioma2018
- Author(s)
  Tsuboi A, Hashimoto N, Fujiki F, Morimoto S, Kagawa N, Nakajima H, Hosen N, Nishida S, Nakata J, Morita S, Sakamoto J, Oji Y, Oka Y, Sugiyama H
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 68(2) Issue: 2 Pages: 331-340
- DOI
  10.1007/s00262-018-2274-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10331, KAKENHI-PROJECT-16K11136, KAKENHI-PROJECT-17K07215, KAKENHI-PROJECT-17K07216
[Journal Article] Efficient and Non-genotoxic RNA-Based Engineering of Human T Cells Using Tumor-Specific T Cell Receptors With Minimal TCR Mispairing2018
- Author(s)
  Campillo-Davo Diana、Fujiki Fumihiro、Van den Bergh Johan M. J.、De Reu Hans、Smits Evelien L. J. M.、Goossens Herman、Sugiyama Haruo、Lion Eva、Berneman Zwi N.、Van Tendeloo Viggo
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 9
- DOI
  10.3389/fimmu.2018.02503
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07215
[Journal Article] A versatile T cell-based assay to assess therapeutic antigen-specific PD-1-targeted approaches2018
- Author(s)
  Versteven Maarten、Bergh Johan M.J. Van den、Broos Katrijn、Fujiki Fumihiro、Campillo-Davo Diana、De Reu Hans、Morimoto Soyoko、Lecocq Quentin、Keyaerts Marleen、Berneman Zwi、Sugiyama Haruo、Van Tendeloo Viggo F.I.、Breckpot Karine、Lion Eva
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 45 Pages: 27797-27808
- DOI
  10.18632/oncotarget.25591
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07215, KAKENHI-PROJECT-17K07216
[Journal Article] Establishment of a novel platform cell line for efficient and precise evaluation of T cell receptor functional avidity2018
- Author(s)
  Morimoto Soyoko、Fujiki Fumihiro、Kondo Kenta、Nakajima Hiroko、Kobayashi Yoshiki、Inatome Miki、Aoyama Nao、Nishida Yuya、Tsuboi Akihiro、Oka Yoshihiro、Nishida Sumiyuki、Nakata Jun、Hosen Naoki、Oji Yusuke、Sugiyama Haruo
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 75 Pages: 34132-34141
- DOI
  10.18632/oncotarget.26139
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07215, KAKENHI-PROJECT-17K07216, KAKENHI-PROJECT-16K11136, KAKENHI-PROJECT-17K15727
[Journal Article] Syndecan-4 as a biomarker to predict clinical outcome for glioblastoma multiforme treated with WT1 peptide vaccine2016
- Author(s)
  Takashima S, Oka Y, Fujiki F, Morimoto S, Nakajima H, Nakae Y, Nakata J, Nishida S, Hosen N, Tatsumi N, Mizuguchi K, Hashimoto N, Oji Y, Tsuboi A, Kumanogoh A, Sugiyama H
- Journal Title
  
  Future Sci OA
  
  Volume: FSO96 Issue: 4
- DOI
  10.4155/fsoa-2015-0008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430162, KAKENHI-PROJECT-15K18446, KAKENHI-PROJECT-15K09173, KAKENHI-PROJECT-15K19550
[Journal Article] A Zbtb7a proto-oncogene as a novel target for miR-125a.2016
- Author(s)
  Hojo N, Tatsumi N, Moriguchi N, Matsumura A, Morimoto S, Nakata J, Fujiki F, Nishida S, Nakajima H, Tsuboi A, Oka Y, Hosen N, Hayashi S, Sugiyama H, Oji Y.
- Journal Title
  
  Molecular Carcinogenesis
  
  Volume: - Issue: 12 Pages: 1-9
- DOI
  10.1002/mc.22446
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430162, KAKENHI-PROJECT-15K18446, KAKENHI-PROJECT-25460685, KAKENHI-PROJECT-15K09476
[Journal Article] Glycosylation Status of CD43 Protein Is Associated with Resistance of Leukemia Cells to CTL-Mediated Cytolysis.2016
- Author(s)
  Hasegawa K, Tanaka S, Fujiki F, Morimoto S, Nakano K, Kinoshita H, Okumura A, Fujioka Y, Urakawa R, Nakajima H, Tatsumi N, Nakata J, Takashima S, Nishida S, Tsuboi A, Oka Y, Oji Y, Miyoshi E, Hirata T, Kumanogoh A, Sugiyama H, Hosen N.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 3 Pages: e0152326-e0152326
- DOI
  10.1371/journal.pone.0152326
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430162, KAKENHI-PROJECT-15K18446, KAKENHI-PROJECT-25460588, KAKENHI-PROJECT-25460685, KAKENHI-PROJECT-26461404
[Journal Article] Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide.2016
- Author(s)
  Oji Y, Hashimoto N, Tsuboi A, Murakami Y, Iwai M, Kagawa N, Chiba Y, Izumoto S, Elisseeva O, Ichinohasama R, Sakamoto J, Morita S, Nakajima H, Takashima S, Nakae Y, Nakata J, Kawakami M, Nishida S, Hosen N, Fujiki F, Morimoto S, Adachi M, Iwamoto M, Oka Y, Yoshimine T, Sugiyama H.
- Journal Title
  
  Int J Cancer.
  
  Volume: 139 Issue: 6 Pages: 1391-401
- DOI
  10.1002/ijc.30182
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462257, KAKENHI-PROJECT-26430162, KAKENHI-PROJECT-26462195, KAKENHI-PROJECT-15K18446, KAKENHI-PROJECT-15K08609, KAKENHI-PROJECT-15K09173, KAKENHI-PROJECT-15K09476, KAKENHI-PROJECT-15K10331, KAKENHI-PROJECT-16K11136, KAKENHI-PROJECT-15K19550
[Journal Article] An essential role of the avidity of T-cell receptor in differentiation of self-antigen-reactive CD8+ T cells2016
- Author(s)
  Kondo K, Fujiki F, Nakajima H, Yatsukawa E, Morimoto S, Tatsumi N, Nishida S, Nakata J, Oka Y, Tsuboi A, Hosen N, Oji Y, Sugiyama H
- Journal Title
  
  Journal of Immunotherapy
  
  Volume: 39 Issue: 3 Pages: 127-139
- DOI
  10.1097/cji.0000000000000114
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09173, KAKENHI-PROJECT-26430162, KAKENHI-PROJECT-15K18446, KAKENHI-PROJECT-15K19550, KAKENHI-PROJECT-25460685
[Journal Article] An Immunocompetent Mouse Model for MLL/AF9 Leukemia Reveals the Potential of Spontaneous Cytotoxic T-Cell Response to an Antigen Expressed in Leukemia Cells.2015
- Author(s)
  Hasegawa K, Tanaka S, Fujiki F, Morimoto S, Nakajima H, Tatsumi N, Nakata J, Takashima S, Nishida S, Tsuboi A, Oka Y, Oji Y, Kumanogoh A, Sugiyama H, Hosen N.
- Journal Title
  
  PLoS One
  
  Volume: 10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26430162
[Journal Article] Two distinct effector memory cell populations of WT1 (Wilms' tumor gene 1)-specific cytotoxic T lymphocytes in acute myeloid leukemia patients2015
- Author(s)
  Nakae Y., Oka Y., Fujiki F., Morimoto S., Kamiya T., Takashima S., Nakata J., Nishida S., Nakajima H., Hosen N., Tsuboi A, Kyo T., Oji Y., Mizuguchi K., Kumanogoh A., Sugiyama H.
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: in press Issue: 7 Pages: 791-804
- DOI
  10.1007/s00262-015-1683-7
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591164, KAKENHI-PROJECT-25830116, KAKENHI-PROJECT-26430162, KAKENHI-PROJECT-15K19550
[Journal Article] Transduction of a Novel HLA-DRB1*04:05-restricted, WT1-specific TCR Gene into Human CD4+ T Cells Confers Killing Activity Against Human Leukemia Cells.2015
- Author(s)
  Katsuhara A, Fujiki F, Aoyama N, Tanii S, Morimoto S, Oka Y, Tsuboi A, Nakajima H, Kondo K, Tatsumi N, Nakata J, Nakae Y, Takashima S, Nishida S, Hosen N, Sogo S, Oji Y, Sugiyama H.
- Journal Title
  
  Anticancer Research
  
  Volume: 35 Pages: 1251-1261
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26430162
[Journal Article] The translation elongation factor eEF2 is a novel tumor-associated antigen overexpressed in various types of cancers.2014
- Author(s)
  Oji Y, Tatsumni N, Izumoto S (34 名省略）
- Journal Title
  
  Int J Oncol
  
  Volume: 44 Issue: 5 Pages: 1461-1469
- DOI
  10.3892/ijo.2014.2318
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23592148, KAKENHI-PROJECT-24591395, KAKENHI-PROJECT-24700991, KAKENHI-PROJECT-25460685, KAKENHI-PROJECT-26462195
[Journal Article] Establishment of HLA-DR4 transgenic mice for the identification of CD4+ T cell epitopes of tumor-associated antigens.2013
- Author(s)
  Yatsuda J, Irie A, Harada K, Michibata Y, Tsukamoto H, Senju S, Tomita Y, Yuno A, Hirayama M, Abu Sayem M, Takeda N, Shibuya I, Sogo S, Fujiki F, Sugiyama H, Eto M, Nishimura Y.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 12 Pages: e84908-e84908
- DOI
  10.1371/journal.pone.0084908
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22133001, KAKENHI-PLANNED-22133005, KAKENHI-PROJECT-23510243, KAKENHI-PROJECT-24700991, KAKENHI-PROJECT-24700994
[Journal Article] In vivo eradication of MLL/ENL leukemia cells by NK cells in the absence of adaptive immunity.2013
- Author(s)
  Nakata J, Nakano K, Okumura A, Mizutani Y, Kinoshita H, Iwai M, Hasegawa K, Morimoto S, Fujiki F, Tatsumi N, Nakajima H, Nakae Y, Nishida S, Tsuboi A, Oji Y, Oka Y, Sugiyama H, Kumanogoh A, Hosen N.
- Journal Title
  
  Leukemia.
  
  Volume: - Issue: 6 Pages: 1316-1325
- DOI
  10.1038/leu.2013.374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591395, KAKENHI-PROJECT-24700991, KAKENHI-PROJECT-25460685
[Journal Article] Maintenance of complete remission after allogeneic stem cell transplantation in leukemia patients treated with Wilms tumor 1 peptide vaccine2013
- Author(s)
  Maeda T, Hosen N, Fukushima K, Tsuboi A, Morimoto S, Matsui T, Sata H, Fujita J, Hasegawa K, Nishida S, Nakata J, Nakae Y, Takashima S, Nakajima H, Fujiki F, Tatsumi N, Kondo T, Hino M, Oji Y, Oka Y, Kanakura Y, Kumanogoh A, Sugiyama H
- Journal Title
  
  Blood Cancer J
  
  Volume: 3 Issue: 8 Pages: e130-e130
- DOI
  10.1038/bcj.2013.29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591423, KAKENHI-PROJECT-24591164, KAKENHI-PROJECT-24591395, KAKENHI-PROJECT-24700991, KAKENHI-PROJECT-25460685, KAKENHI-PROJECT-25461419, KAKENHI-PROJECT-25461450, KAKENHI-PROJECT-25830116
[Journal Article] Identification of a Wilms' tumor1-derived immunogenic CD4(+) T-cell epitope that is recognized in the context of common Caucasian HLA-DR haplotypes2013
- Author(s)
  Anguille S, Fujiki F, et al
- Journal Title
  
  Leukemia
  
  Volume: 27 Issue: 3 Pages: 748-50
- DOI
  10.1038/leu.2012.248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700991
[Journal Article] Functional human Th17 clones with WT1-specific helper activity.2013
- Author(s)
  Tachino S, Fujiki F, Oka Y, Tsuboi A, Morimoto S, Lin YH, Tamanaka T, Kondo K, Nakajima H, Nishida S, Hosen N, Oji Y, Kumanogoh A, Sugiyama H.
- Journal Title
  
  Cancer Immunol Immunother.
  
  Volume: 62（4） Issue: 4 Pages: 801-10
- DOI
  10.1007/s00262-012-1385-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592123, KAKENHI-PROJECT-24591164, KAKENHI-PROJECT-24700991, KAKENHI-PROJECT-25462257, KAKENHI-PROJECT-25830116
[Journal Article] HLA-DPB1*05: 01-restricted WT1332-specific TCR-transduced CD4+ T lymphocytes display a helper activity for WT1-specific CTL induction and a cytotoxicity against leukemia cells.2013
- Author(s)
  Lin Y, Fujiki F, Katsuhara A, Oka Y, Tsuboi A, Aoyama N, Tanii S, Nakajima H, Tatsumi N, Morimoto S, Tamanaka T, Tachino S, Hosen N, Nishida S, Oji Y, Kumanogoh A, Sugiyama H.
- Journal Title
  
  J Immunother.
  
  Volume: 36（3） Issue: 3 Pages: 159-70
- DOI
  10.1097/cji.0b013e3182873581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592123, KAKENHI-PROJECT-23790622, KAKENHI-PROJECT-24591164, KAKENHI-PROJECT-24700991, KAKENHI-PROJECT-25460685, KAKENHI-PROJECT-25462257
[Journal Article] Biased usage of T cell receptor β-chain variable region genes of Wilms' tumor gene (WT1)-specific CD8^+ T cells in patients with solid tumors and healthy donors2012
- Author(s)
  Morimoto S., et al
- Journal Title
  
  Cancer Science
  
  Volume: 103 Issue: 3 Pages: 408-414
- DOI
  10.1111/j.1349-7006.2011.02163.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590991, KAKENHI-PROJECT-21591205, KAKENHI-PROJECT-21591870, KAKENHI-PUBLICLY-22103508, KAKENHI-PROJECT-22700896, KAKENHI-PROJECT-23390364, KAKENHI-PROJECT-23592123, KAKENHI-PROJECT-23592148, KAKENHI-PROJECT-24592160
[Journal Article] Enhanced tumor immunity of WT1 peptide vaccination by interferon-βadministration2012
- Author(s)
  Nakajima H, Oka Y, Tsuboi A, Tatsumi N, Yamamoto Y, Fujiki F, et al.(他10名、6番目)
- Journal Title
  
  Vaccine
  
  Volume: 30 Pages: 722-729
- URL
  http://dx.doi.org/10.1016/j.vaccine.2011.11.074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700896
[Journal Article] Recognition of a natural WT1 epitope by a modified WT1 peptide-specific T-cell receptor2012
- Author(s)
  Tamanaka T, Oka Y, Fujiki F, et al
- Journal Title
  
  Anticancer Res
  
  Volume: 32 Pages: 5201-9
- URL
  http://ar.iiarjournals.org/content/32/12/5201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700991
[Journal Article] Recognition of a natural WT1 epitope by a modified WT1 peptide-specific T-cell receptor2012
- Author(s)
  Tamanaka T, Oka Y, Fujiki F, Tsuboi A, Katsuhara A, Nakajima H, Hosen N, Nishida S, Lin YH, Tachino S, Akatsuka Y, Kuzushima K, Oji Y, Kumanogoh A, Sugiyama H
- Journal Title
  
  Anticancer Research
  
  Volume: 32 Pages: 5201-5209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700991
[Journal Article] Biased usage of BV gene families of T-cell receptors of WT1(Wilms' tumor gene)-specific CD8+ T cells in patients with myeloid malignancies2010
- Author(s)
  Tanaka-Harada Y, Kawakami M, Oka Y, Tsuboi A, Katagiri T, Elisseeva OA, Nishida S, Shirakata T, Hosen N, Fujiki F, et al.(他6名、10番目)
- Journal Title
  
  Cancer Sci
  
  Volume: 101 Issue: 3 Pages: 594-600
- DOI
  10.1111/j.1349-7006.2009.01453.x
- NAID
  10026589035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700896
[Journal Article] High frequencies of less differentiated and more proliferative WT1-specific CD8+ T cells in bone marrow (BM) in tumor-bearing patients: an important role of BM as a secondary lymphoid organ.2010
- Author(s)
  Murao A, Oka Y, Tsuboi A, Elisseeva OA, Harada Y, Fujiki F, Nakajima H, Nishida S, Hosen N, Shirakata T, Hashimoto N, Myoui A, Ueda T, Takeda Y, Osaki T, Enomoto T, Yoshikawa H, Kimura T, Oji Y, Kawase I, Sugiyama H.
- Journal Title
  
  Cancer Science (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015028
[Journal Article] Biased usage of BV gene families of T cell receptors of WT1 (Wilms' tumor gene)-specific CD8+ T cells in patients with myeloid malignancies2010
- Author(s)
  Tanaka-Harada Y, Kawakami M, Oka Y, Tsuboi A, Katagiri T, Elisseeva O, Nishida S, Shirakata T, Hosen N, Fujiki F, Murao A, Nakajima H, Oji Y, Kanda Y, Kawase I, Sugiyama H.
- Journal Title
  
  Cancer Science 101
  
  Pages: 594-600
- NAID
  10026589035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015028
[Journal Article] A clear correlation between WT1-specific Th response and clinical responsein WT1 CTL epitope vaccination.2010
- Author(s)
  Fujiki Fumihiro
- Journal Title
  
  Anticancer Research
  
  Volume: 30 Pages: 2247-2254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700896
[Journal Article] A clear correlation between WT1-specific Th response and clinical response in WT1 CTL epitope vaccination2010
- Author(s)
  Fujiki F, Oka Y, Kawakatsu M, et al.(他22名、1番目)
- Journal Title
  
  Anticancer Res
  
  Volume: 30 Pages: 2247-2254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700896
[Journal Article] High frequencies of less differentiated and more proliferative WT1-specific CD8+ T cells in bone marrow in tumor-bearing patients : an important role of bone marrow as a secondary lymphoid organ2010
- Author(s)
  Murao A, Oka Y, Tsuboi A, Elisseeva OA, Tanaka-Harada Y, Fujiki F, et al.(他15名、6番目)
- Journal Title
  
  Cancer Sci
  
  Volume: 101 Issue: 4 Pages: 848-854
- DOI
  10.1111/j.1349-7006.2009.01468.x
- NAID
  10026590478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700896
[Journal Article] A WT1 protein-derived, naturally processed 16-mer peptide, WT1332, is a promiscuous helper peptide for induction of WT1-specific Th1-type CD4+ T cells.2008
- Author(s)
  Fujiki F, Oka Y, Kawakatsu M, Tsuboi A, Nakajima H, Elisseeva OA, Harada Y, Li Z, Tatsumi N, Kamino E, Shirakata T, Nishida S, Taniguchi Y, Kawase I, Oji Y, Sugiyama H.
- Journal Title
  
  Microbiol Immunol 52
  
  Pages: 591-600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015028
[Journal Article] Identification of a WT1 protein-derived peptide, WT1187 as an HLA-A*0206-restricted, WT1-specific CTL epitope" is currently at the following stage of production.2008
- Author(s)
  Li Z, Oka Y, Tsuboi A, Fujiki F, Harada Y, Nakajima H, Masuda T, Fukuda Y, Kawakatsu M, Morimoto S, Katagiri T, Tatsumi N, Hosen N, Shirakata T, Nishida S, Kawakami Y, Udaka K, Kawase I, Oji Y, Sugiyama H.
- Journal Title
  
  Microbiol Immunol 52
  
  Pages: 551-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015028
[Journal Article] Identification and characterization of a WT1 (Wilms' tumor gene) protein-derived HLA-DRB1*0405-restricted 16-mer helper peptide that promotes the induction and activation of WT1-specific cytotoxic T lymphocytes.2007
- Author(s)
  Fujiki F, Oka Y, Tsuboi A, Kawakami M, Nakajima H, Elisseeva OA, Harada Y, Ito K, Li Z, Tatsumi N, Sakaguchi N, Fujioka T, Masuda T, Yasukawa M, Udaka K, Oji Y, Sugiyama H.
- Journal Title
  
  J Immunother 30
  
  Pages: 282-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015028
[Journal Article] Identification and characterization of a WT1 (Wilms' tumor gene) protein-derived HLA-DRB1*0405-restricted 16-mer helper peptide that promotes the induction and activation of WT1-specific cytotoxic T lymphocytes.2007
- Author(s)
  Fujiki, F, et. al.
- Journal Title
  
  J lmmunother. 30
  
  Pages: 282-293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015028
[Journal Article] WT1(235), a ninemer peptide derived from Wilms' tumor gene product, is a candidate peptide for the vaccination of HLA-A*0201-positive patients with hematopoietic malignancies.2005
- Author(s)
  Li Z, Oka Y, Tsuboi A, Masuda T, Tatsumi N, Kawakami M, Fujioka T, Sakaguchi N, Nakajima H, Fujiki F, Udaka K, Oji Y, Kawase I, Sugiyama H.
- Journal Title
  
  Int J Hematol 82
  
  Pages: 458-459
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015028
[Journal Article] Th1-biased humoral immune responses against Wilms tumor gene WT1 product in the patients with hematopoietic malignancies.2005
- Author(s)
  Wu F, Oka Y, Tsuboi A, Elisseeva O. A, Nakajima H, Fujiki F, Masuda T, Murakami M, Yoshihara S, Ikegame K, Hosen N, Kawakami M, Nakagawa M, Kubota T, Soma T, Yamagami T, Tsukaguchi M, Ogawa H, Oji Y, Hamaoka T, Kawase I, Sugiyama H.
- Journal Title
  
  Leukemia 19
  
  Pages: 268-274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015028
[Journal Article] Identification and characterization or a WT1(Wilms' tumor gene) protein-derived HLA-DRB1^*0405-restricted 16-mer helper peptide that promotes the induction and activation of WT1-specific cytotoxic T lymohocytes.
- Author(s)
  Fujiki, F., et al.
- Journal Title
  
  J Immunother. (In press)
- Data Source
  KAKENHI-PROJECT-17015028
[Patent] 抗原特異的ヘルパーT細胞レセプター遺伝子2013
- Inventor(s)
  杉山治夫、藤木文博
- Industrial Property Rights Holder
  杉山治夫、藤木文博
- Industrial Property Rights Type
  特許
- Filing Date
  2013-09-12
- Overseas
- Data Source
  KAKENHI-PROJECT-24700991
[Patent] 抗原特異的ヘルパーT 細胞レセプター遺伝子2013
- Inventor(s)
  杉山治夫、藤木文博
- Industrial Property Rights Holder
  杉山治夫、藤木文博
- Industrial Property Rights Type
  特許
- Filing Date
  2013-09-12
- Overseas
- Data Source
  KAKENHI-PROJECT-24700991
[Presentation] Identification of candidate target genes for maintaining TCF1high CD8+ T cells under high IL-2 conditions2024
- Author(s)
  Satsuki Okafuji, Soyoko Morimoto, Fumihiro Fujiki, Akinori Nagata, Jun Nakata, Hiroko Nakajima, Sumiyuki Nishida, Yoshihiro Oka, Yusuke Oji, Haruo Sugiyama
- Organizer
  第52回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K21389
[Presentation] TCF1レポーターマウスを活用した腫瘍局所と所属リンパ節に存在する癌抗原特異的CD8+ T細胞の分類と解析2023
- Author(s)
  永田暁教藤木文博森本創世子中田潤西田純幸中島博子橋井佳子坪井昭博岡芳弘尾路祐介杉山治夫
- Organizer
  第27回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K21389
[Presentation] Comparison of WT1-specific T cell responses in recurrent glioma patients received CTL + Helper peptide vaccine vs CTL peptide vaccine alone2019
- Author(s)
  Fumihiro Fujiki, Akihiro Tsuboi, Soyoko Morimoto, Naoya Hashimoto, Miki Inatome, Yoshihiro Oka, Yusuke Oji, Haruo Sugiyama
- Organizer
  International Conference on WT1 Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07215
[Presentation] 急性骨髄性白血病に対するWT1ワクチン療法の現状および今後の展望2019
- Author(s)
  中田潤、中江吉希、川上学、森本創世子、中島博子、藤木文博、西田純幸、保仙直毅、坪井昭博、尾路祐介、岡芳弘、杉山治夫
- Organizer
  第11回日本血液疾患免疫療法学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07215
[Presentation] Establishment of a novel platform cell line for efficient and precise evaluation of T cell receptor functional avidity and its application2019
- Author(s)
  Soyoko Morimoto, Fumihiro Fujiki, Maarten Versteven, Kenta Kondo, Hiroko Nakajima, Yoshiki Kobayashi, Miki Inatome, Nao Aoyama, Yuya Nishida, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Eva Lion, Haruo Sugiyama
- Organizer
  International Conference on WT1 Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07215
[Presentation] 脳腫瘍患者におけるWT1ヘルパーペプチド併用WT1ペプチドワクチン療法の免疫モニタリング解析2019
- Author(s)
  森本創世子、坪井昭博、藤木文博、橋本直哉、稲留美希、中島博子、中田潤、保仙直毅、尾路祐介、岡芳弘、杉山治夫
- Organizer
  第47回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-17K07215
[Presentation] 再発脳腫瘍患者におけるWT1ヘルパーペプチド併用WT1ペプチドワクチン療法の免疫モニタリング解析2019
- Author(s)
  藤木文博、坪井昭博、森本創世子、橋本直哉、稲留美希、中島博子、中田潤、保仙直毅、尾路祐介、岡芳弘、杉山治夫
- Organizer
  第11回日本血液疾患免疫療法学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07215
[Presentation] 癌抗原特異的T細胞受容体のfunctional avidity を効率よく正確に評価できるplatform細胞の作製とその応用例2019
- Author(s)
  森本創世子、藤木文博、近藤健太、中島博子、中田潤、保仙直毅、橋井佳子、坪井昭博、岡芳弘、尾路祐介、杉山治夫
- Organizer
  第11回日本血液疾患免疫療法学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07215
[Presentation] Electroporation of Dicer-Substrate siRNA Duplexes Targeting Endogenous TCR Enhance Tumor Killing Activity of Wilms' Tumor 1 (WT1)-Specific TCR-Redirected Cytotoxic T Cells2016
- Author(s)
  Diana Campillo-Davo, Fumihiro Fujiki, Johan M.J. Van den Bergh, Evelien L. Smits, Haruo Sugiyama, Viggo F.I. Van Tendeloo and Zwi N. Berneman
- Organizer
  ASH Annual Meeting
- Place of Presentation
  San Diego Convention Center
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430162
[Presentation] Cloning of WT1332 helper peptide-specific TCRs and their application for cancer immunotherapy2015
- Author(s)
  Fumihiro Fujiki, Akiko Katsuhara, Yuhung Lin, Nao Aoyama, Satoe Tanii, Soyoko Morimoto, Hiroko Nakajima, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Haruo Sugiyama
- Organizer
  The 8th International Conference on WT1 in Human Neoplasia
- Place of Presentation
  KBS Kyoto Hall, Kyoto, JAPAN
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-26430162
[Presentation] Isolation and validation of WT1-specific T cell receptors from leukemia patients after successful DC vaccination for redirected T-cell immunotherapy2015
- Author(s)
  Fumihiro Fujiki, Diana Campillo-Davo, Johan Van den Bergh, Evelien Smits, Zwi Berneman, Haruo Sugiyama, Viggo Van Tendeloo
- Organizer
  The 8th International Conference on WT1 in Human Neoplasia
- Place of Presentation
  KBS Kyoto Hall, Kyoto, JAPAN
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-26430162
[Presentation] HLA クラス II 拘束性 WT1 由来ヘルパーペプチド特異的 TCR 遺伝子を導入された CD4+ T 細胞は in vivo において anti-leukemia activity を発揮する2014
- Author(s)
  勝原晶子、藤木文博、青山奈央、谷井里江、森本創世子、岡芳弘、坪井昭博、中島博子、辰巳直也、保仙直毅、尾路祐介、杉山治夫
- Organizer
  第6回血液疾患免疫療法研究会
- Place of Presentation
  京都大学　芝蘭会館
- Year and Date
  2014-09-06
- Data Source
  KAKENHI-PROJECT-26430162
[Presentation] HLA-DPB1*05 : 01 拘束性WT1 特異的TCR を導入されたCD4+T細胞はヘルパー活性と細胞傷害活性を有する2013
- Author(s)
  藤木文博, 等
- Organizer
  第17回日本がん免疫学会総会
- Place of Presentation
  ANA クラウンプラザホテル宇部
- Year and Date
  2013-07-04
- Data Source
  KAKENHI-PROJECT-24700991
[Presentation] HLA-DPB1*05:01拘束性WT1特異的TCRを導入されたCD4+T細胞はヘルパー活性と細胞傷害活性を有する2013
- Author(s)
  藤木文博、林ユウ宏、勝原晶子、岡芳弘、坪井昭博、青山奈央、谷井里江、中島博子、森本創世子、保仙直毅、西田純幸、尾路祐介、熊ノ郷淳、杉山治夫
- Organizer
  第17回日本がん免疫学会総会
- Place of Presentation
  ANAクラウンプラザホテル宇部
- Data Source
  KAKENHI-PROJECT-24700991
[Presentation] HLA class II-restricted WT1-specific TCR-transduced CD4+ T cells display a helper activity for WT1-specific CTL induction and a cytotoxicity against leukemia cells.2013
- Author(s)
  Fumihiro Fujiki, Yuhung Lin, Akiko Katsuhara, Yoshihiro Oka, Akihiro Tsuboi, Nao Aoyama, Satoe Tanii, Hiroko Nakajima, Naoya Tatsumi, Soyoko Morimoto, Naoki Hosen, Sumiyuki Nishida, Yusuke Oji, Atsushi Kumanogoh and Haruo Sugiyama
- Organizer
  The 4th JSH International symposium 2013
- Place of Presentation
  YAMATOYA-HONTEN, Ehime
- Data Source
  KAKENHI-PROJECT-24700991
[Presentation] HLA class II拘束性WT1特異的T Cell Receptor遺伝子導入によるヘルパー活性とキラー活性を有するCD4+ T細胞の作製2013
- Author(s)
  藤木文博、林ユウ宏、勝原晶子、岡芳弘、坪井昭博、青山奈央、谷井里江、中島博子、森本創世子、保仙直毅、尾路祐介、熊ノ郷淳、杉山治夫
- Organizer
  第41回日本臨床免疫学会総会
- Place of Presentation
  海峡メッセ下関
- Invited
- Data Source
  KAKENHI-PROJECT-24700991
[Presentation] HLA class II 拘束性WT1特異的T Cell Receptor 遺伝子導入によるヘルパー活性とキラー活性を有するCD4+T 細胞の作製2013
- Author(s)
  藤木文博, 等
- Organizer
  第41回日本臨床免疫学会総会
- Place of Presentation
  海峡メッセ下関
- Year and Date
  2013-11-28
- Invited
- Data Source
  KAKENHI-PROJECT-24700991
[Presentation] HLA class II-restricted WT1-specific TCR-transduced CD4+ T cells display a helper activity for WT1-specific CTL induction and acytotoxicity against leukemia cells2013
- Author(s)
  Fujiki F, et al
- Organizer
  The 4th JSH International Symposium 2013
- Place of Presentation
  YAMATOTA-HONTEN, Ehime
- Year and Date
  2013-05-24
- Data Source
  KAKENHI-PROJECT-24700991
[Presentation] Development of HLA-DR4 transgenic mice useful for identification of CD4+ T cell epitope of tumor-associated antigens2012
- Author(s)
  Yatsuda Junji, Irie Atsushi, Michibata Yayoi, Harada Kumiko, Tomita Yusuke, Yuno Akira, Takeda Naoki, Shibuya Isao, Sogo Shinji, Fujiki Fumihiro, et al
- Organizer
  日本免疫学会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-24700991
[Presentation] Cancer antigen WT1-specific helper and suppressive Th17 derived from a single precursor cell2012
- Author(s)
  Tachino Sho, Oka Yoshihiro, Fumihiro Fujiki, Tsuboi Akihiro, Tamanaka Taichi, Kondo Kenta, Hosen Naoki, Oji Yusuke, Kumanogoh Atsushi, Sugiyama Haruo
- Organizer
  日本免疫学会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-24700991
[Presentation] CD4＋T細胞が認識するがん抗原ペプチドを迅速に同定できるHLA-DR4トランスジェニックマウスの樹立2012
- Author(s)
  Yatsuda Junji, Irie Atsushi, Michibata Yayoi, Harada Kumiko, Tomita Yusuke, Yuno Akira, Takeda Naoki, Shibuya Isao, Sogo Shinji, Fujiki Fumihiro, et al
- Organizer
  日本癌学会
- Place of Presentation
  Royton Sapporo
- Data Source
  KAKENHI-PROJECT-24700991
[Presentation] Establishment of HLA-DR4 transgenic mice useful for rapid screening of HLA-DR4-restricted CD4+ T cell epitope peptides2012
- Author(s)
  Irie Atsushi, Yatsuda Junji, Michibata Yayoi, Harada Kumiko, Takeda Naoki, Shibuya Isao, Sogo Shinji, Fujiki Fumihiro, Sugiyama Haruo, Nishimura Yasuharu
- Organizer
  日本がん免疫学会
- Place of Presentation
  北海道大学学術交流会館
- Data Source
  KAKENHI-PROJECT-24700991
[Presentation] Biased usage of T cell receptor beta-chain variable region genes of cancer antigen WT1-specific CTLs in patients with solid tumors and healthy donors2012
- Author(s)
  Morimoto Soyoko, Oka Yoshihiro, Tsuboi Akihiro, Fujiki Fumihiro, Nakajima Hiroko, Hosen Naoki, Oji Yusuke, Kumanogoh Atsushi, Sugiyama Haruo
- Organizer
  日本免疫学会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-24700991
[Presentation] HLA-DR4拘束性CD4+Th細胞に抗原提示機能を有するHLA-DR4トランスジェニックマウスの樹立2012
- Author(s)
  入江厚、矢津田旬二、道端弥生、原田久美子、竹田直樹、澁谷功、十河真司、藤木文博、杉山治夫、西村泰治
- Organizer
  日本組織適合性学会
- Place of Presentation
  明治大学駿河台キャンパス　アカデミーコモン・リバティタワー
- Data Source
  KAKENHI-PROJECT-24700991
[Presentation] 骨髄異形成症候群(MDS)に対する少量WT1ペプチド療法2006
- Author(s)
  川上学、坪井昭博、西田純幸、白方俊章、原田ゆきえ、中島博子、藤木文博、李哲雨、OLGA ELISSEEVA、尾路祐介、古川佳央、林孝昌、岡芳弘、杉山治夫
- Organizer
  第68回日本血液学会総会・第48回日本臨床血液学会総会合同総会
- Place of Presentation
  福岡
- Year and Date
  2006-10-07
- Data Source
  KAKENHI-PROJECT-17015028
[Presentation] WT1ペプチド癌ワクチン投与患者末梢血中のWT1特異的CTLの解析2006
- Author(s)
  岡芳弘、OLGA ELISSEEBA、長谷浩志、川上学、西田純幸、白方俊章、原田ゆきえ、中島博子、李哲雨、藤木文博、尾路祐介、川瀬一郎、坪井昭博、杉山治夫
- Organizer
  第68回日本血液学会総会・第48回日本臨床血液学会総会合同総会
- Place of Presentation
  福岡
- Year and Date
  2006-10-07
- Data Source
  KAKENHI-PROJECT-17015028
[Presentation] WT1 specific CTLs in WT1 peptide vaccine-treated patients2005
- Author(s)
  Olga Elisseeva, Yoshihiro Oka, Akihiro Tsuboi, Hiroshi Hase, Hiroko Nakajima, Yukie Harada, Manabu Kawakami, Fumihiro Fujiki, Sumiyuki Nishida, Toshiaki Shirakata, Satoshi Oono, Ichirou Kawase, Yusuke Oji, Haruo Sugiyama
- Organizer
  The Second International Conference on WT1 in Human Neoplasia
- Place of Presentation
  Kyoto
- Year and Date
  2005-10-22
- Data Source
  KAKENHI-PROJECT-17015028
[Presentation] Identification and characterization of a WT1 (Wilms' tumor gene) protein-derived HLA-DRB1*0405-restricted 16-mer helper peptide that promotes the induction and activation of WT1-specific cytotoxic T lymphocytes2005
- Author(s)
  Fumihiro Fujiki, Yoshihiro Oka, Akihiro Tsuboi, Manabu Kawakami, Mai Kawakatsu, Hiroko Nakajima, Olga A. Elisseeva, Yukie Harada, Ken Ito, Zheyu Li, Naoya Tatsumi, Nao Sakaguchi, Tatsuya Fujioka, Tomoki Masuda, Masaki Yasukawa, Keiko Udaka, Yusuke Oji, Haruo Sugiyama
- Organizer
  The Second International Conference on WT1 in Human Neoplasia
- Place of Presentation
  Kyoto
- Year and Date
  2005-10-21
- Data Source
  KAKENHI-PROJECT-17015028
[Presentation] 骨髄異形成症候群(MDS)に対する少量WT1ペプチド療法2005
- Author(s)
  川上学, 坪井昭博、原田ゆきえ, 中島博子, 白方俊章, 大野智, 藤木文博, 李哲雨, エリセーバ・オリガ, 尾路祐介, 古川佳央, 岡芳弘, 杉山治夫
- Organizer
  第9回基盤的癌免疫研究会総会
- Place of Presentation
  東京
- Year and Date
  2005-07-15
- Data Source
  KAKENHI-PROJECT-17015028
[Presentation] WT1特異的CD4*ヘルパーT細胞を誘導できるHLA-classII拘束性ペプチドの同定2005
- Author(s)
  藤木文博, 岡芳弘, 坪井昭博, 川上学, 川勝真衣, 中島博子, オリガ・エリセーバ, 原田ゆきえ, 李哲雨, 伊藤憲, 宇高恵子, 尾路祐介, 杉山治夫
- Organizer
  第64回日本癌学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2005-09-16
- Data Source
  KAKENHI-PROJECT-17015028
[Presentation] WT1-peptide vaccination for acute myeloid leukemia2005
- Author(s)
  Manabu Kawakami, Yoshihiro Oka, Akihiro Tsuboi, Hiroko Nakajima, Olga A. Elisseeva, Hiroshi Hase, Yukie Harada, Fumihiro Fujiki, Zheyu LI, Tatsumi, Sumiyuki Nishida, Satoshi Ohno, Toshiaki Shirakata, Ichiro Kawase, Yusuke Oji, Haruo Sugiyama
- Organizer
  The Second International Conference on WT1 in Human Neoplasia
- Place of Presentation
  Kyoto
- Year and Date
  2005-10-22
- Data Source
  KAKENHI-PROJECT-17015028
[Presentation] Analysis of correlation of WT1-specific immune responses before WT1 peptide vaccination and clinical responses
- Author(s)
  Soyoko Morimoto, Yoshihiro Oka, Akihiro Tsuboi, Naoki Hosen, Sumiyuki Nishida, Fumihiro Fujiki, Hiroko Nakajima, Yusuke Oji, Haruo Sugiyama
- Organizer
  The 7th International Conference on WT1 in human neoplasia
- Place of Presentation
  Hospital Sant Pau, Events Hall, Barcelona
- Year and Date
  2014-04-22 – 2014-04-23
- Data Source
  KAKENHI-PROJECT-26430162
[Presentation] HLA class II拘束性WT1由来ヘルパーペプチド特異的TCRを導入されたCD4+T細胞はヘルパー活性と細胞傷害活性を有する
- Author(s)
  藤木文博、林ユウ宏、勝原晶子、岡芳弘、坪井昭博、青山奈央、谷井里江、中島博子、森本創世子、保仙直毅、西田純幸、尾路祐介、熊ノ郷淳、杉山治夫
- Organizer
  第５回造血器腫瘍免疫療法研究会
- Place of Presentation
  ウインク愛知
- Data Source
  KAKENHI-PROJECT-24700991

1. SUGIYAMA Haruo (70162906)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
2. OKA Yoshihiro (20273691)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
3. OJI Yusuke (20294100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
4. HOSEN Naoki (10456923)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. 瀬尾茂人 (30432462)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NISHIDA Sumiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
7. Morimoto Soyoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. KAGAWA Naoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. IZUMOTO Shuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. TSUBOI Akihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
11. CHIBA Yasuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 平山令明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 西村康治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 日野雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 橋本直哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

FUJIKI Fumihiro 藤木 文博

藤木 文博 フジキ フミヒロ

Research Projects

Research Products

Co-Researchers

LCMV慢性感染症モデルにおける疲弊T細胞の克服と癌免疫療法への応用Principal Investigator

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Overcoming T cell exhaustion in chronic LCMV infection model and its application to cancer immunotherapyPrincipal Investigator

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網羅的遺伝子ノックアウト技術を活用した新規がんー免疫チェックポイント標的薬の創製Principal Investigator

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Elucidation of molecular mechanism of T cell terminal differentiation lineage for cancer immunotherapyPrincipal Investigator

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A novel pathway regulating memory T cell development for cancer immunotherapyPrincipal Investigator

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Development of a novel cancer immunotherapy based on efficient induction of memory T cells.Principal Investigator

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Identification of novel master gene controlling memory CD4+ T cell for improving cancer immunotherapyPrincipal Investigator

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Development of molecular diagnosis and molecule-targeted therapy for leukemia

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[Journal Article] Establishment of a novel NFAT-GFP reporter platform useful for the functional avidity maturation of HLA class II-restricted TCRs2023

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[Journal Article] T Cell-Intrinsic Vitamin A Metabolism and Its Signaling Are Targets for Memory T Cell-Based Cancer Immunotherapy2022

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[Journal Article] Reader-free ELISPOT assay for immuno-monitoring in peptide-based cancer vaccine immunotherapy2020

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[Journal Article] Immune adjuvant therapy using Bacillus Calmette-Gu&eacute;rin cell wall skeleton (BCG-CWS) in advanced malignancies: A phase 1 study of safety and immunogenicity assessments.2019

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[Journal Article] Combination Gemcitabine and WT1 Peptide Vaccination Improves Progression-Free Survival in Advanced Pancreatic Ductal Adenocarcinoma: A Phase II Randomized Study.2018

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[Journal Article] Extremely strong infiltration of WT1-specific CTLs into mouse tumor by the combination vaccine with WT1-specific CTL and helper peptides2018

Author(s)

FUJIKI Fumihiro 藤木文博

藤木文博フジキフミヒロ

[Journal Article] Immune adjuvant therapy using Bacillus Calmette-Guérin cell wall skeleton (BCG-CWS) in advanced malignancies: A phase 1 study of safety and immunogenicity assessments.2019