Niki Toshiro 仁木敏朗

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NIKI Toshiro 仁木敏朗

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Researcher Number	40558508
Other IDs	https://orcid.org/0000-0003-4531-1331
Affiliation (Current)	2024: 香川大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2010 – 2024: 香川大学, 医学部, 助教 2017: 香川大学, 医学部, その他
Review Section/Research Field	Principal Investigator Basic Section 37030:Chemical biology-related / Basic Section 49070:Immunology-related / Drug development chemistry / Immunology Except Principal Investigator Basic Section 53010:Gastroenterology-related / Infectious disease medicine / 膠原病・アレルギー・感染症内科学 / Hematology / Experimental pathology
Keywords	Principal Investigator ガレクチン９ / レクチン / ガレクチン / スクリーニング / 免疫チェックポイント阻害薬 / 細胞外小胞 / 免疫調節 / ソーティング / エクソソーム / 遺伝子 … More / 免疫学 / オートファジー / KRAS変異 / 融合タンパク質 / 一本鎖抗体 / 大腸ガン / 制御性T細胞 / 感染症 / 免疫 / 炎症 / 糖鎖 / 免疫制御 / アレルギー / ガン / 自己免疫疾患 … More Except Principal Investigator ガレクチン９ / ガレクチン / バイオマーカー / オステオポンチン / デング熱 / 肝細胞癌 / ガレクチン-9 / microRNA / micro RNA / Galectin-9 / Osteopontin / 災害感染症 / 熱帯感染症 / レプトスピローシス / マラリア / デング / デングウイルス / ガレクチン9 / 耐性株 / 分子標的治療薬 / 抗がん作用 / 耐性癌細胞 / エピガロカテキンガレート / Galectin-9 microRNA / 胆管細胞癌 / エクソソーム / 転移性肝癌 / チクングニヤ / STH-PAS / ブレフェラマイド / マトリセルラー蛋白 / 新型コロナウイルス / エイズ結核 / 結核 / エイズ / COVID-19 / エイズ　結核 / 熱帯災害感染症 / Galection-9 / マトリセルラー蛋白質 / 熱帯 / マトリセルラータンパク質 / ガレクチン－９ / 災害 / Th17細胞 / 国際情報交換 / Th17 / 糖鎖 / Ｔｈ１７細胞 / プロモーター / ガレクチンー９ / デング出血熱 / マクロファージ / 炎症 / 癌 / 免疫学 / ガレクチン 9 Less

Development of small molecule Galectin-9 antagonists as a novel immune checkpoint inhibitorPrincipal Investigator
- Principal Investigator
  
  仁木敏朗
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Kagawa University
Examination of the effect of combination therapy of galectin-9 and epigallocatechin gallate on hepatocellular carcinoma
- Principal Investigator
  
  正木勉
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kagawa University
Functional elucidation of two forms of Galectin-9 and their potential application to diagnosisPrincipal Investigator
- Principal Investigator
  
  仁木敏朗
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kagawa University
Anti-tumor effect of Galectin-9 on metastatic hepatocellular carcinoma and its microRNA basis
- Principal Investigator
  
  Masaki Tsutomu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kagawa University
Matricellular proteins as severity markers for disaster or tropical infectious diseases
- Principal Investigator
  
  Hattori Toshio
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kibi International University
A study on preparation of single receptor specific lectin and its usefulnessPrincipal Investigator
- Principal Investigator
  
  Niki Toshiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kagawa University
A study on the clinical significance of matri-cellular proteins in tropical and disaster infections
- Principal Investigator
  
  Hattori Toshio
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kibi International University
  Tohoku University
Th17-suppressing novel regulatory T cells and the use thereofPrincipal Investigator
- Principal Investigator
  
  Niki Toshiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Kagawa University
Clinical Utilities of new biomarker for dengue virus infection
- Principal Investigator
  
  HATTORI Toshio
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  Tohoku University
The alteration of sugar chain profiling during the differentiation into IL-17-producing helper T cells
- Principal Investigator
  
  OOMIZU Souichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kagawa University
Possible mechanisms of galectin-9-induced immunoregulatory macrophages
- Principal Investigator
  
  HIRASHIMA Mitsuomi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kagawa University

[Journal Article] Plasma N‐Cleaved Galectin‐9 Is a Surrogate Marker for Determining the Severity of COVID‐19 and Monitoring the Therapeutic Effects of Tocilizumab2023
- Author(s)
  Hozumi H, Maeda Y, Niki T, Chagan-Yasutan H, Bai G, Matsuba T, Furushima D, Ashino y, Hattori T
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 24 Issue: 4 Pages: 3591-3591
- DOI
  10.3390/ijms24043591
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K10396, KAKENHI-PROJECT-19K08932, KAKENHI-PROJECT-21K07068
[Journal Article] Human galectin-9 potently enhances SARS-CoV-2 replication and inflammation in airway epithelial cells2023
- Author(s)
  Du Li、Bouzidi Mohamed S、Gala Akshay、Deiter Fred、Billaud Jean-Noel、Yeung Stephen T、Dabral Prerna、Jin Jing、Simmons Graham、Dossani Zain Y、Niki Toshiro、Ndhlovu Lishomwa C、Greenland John R、Pillai Satish K
- Journal Title
  
  Journal of Molecular Cell Biology
  
  Volume: 15 Issue: 4 Pages: 1-14
- DOI
  10.1093/jmcb/mjad030
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07068
[Journal Article] Galectin-9 protects humanized-ACE2 immunocompetent mice from SARS-CoV-2 infection2022
- Author(s)
  Yeung Stephen T.、Premeaux Thomas A.、Du Li、Niki Toshiro、Pillai Satish K.、Khanna Kamal M.、Ndhlovu Lishomwa C.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 1011185-1011185
- DOI
  10.3389/fimmu.2022.1011185
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07068
[Journal Article] High Levels of The Cleaved Form of Galectin-9 And Osteopon-tin In the Plasma are Associated with Inflammatory Markers That Reflect the Severity of Covid-19 Pneumonia2021
- Author(s)
  Bai Gaowa、Furushima Daisuke、Niki Toshiro、Matsuba Takashi、Maeda Yosuke、Atsushi Takahashi、Hattori Toshio、Ashino Yugo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Pages: 1-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01690
[Journal Article] Plasma Levels of a Cleaved Form of Galectin-9 Are the Most Sensitive Biomarkers of Acquired Immune Deficiency Syndrome and Tuberculosis Coinfection2020
- Author(s)
  Padilla ST, Niki T, Furushima D, Bai G, Chagan-Yasutan H, Telan EF, Tactacan-Abrenica RJ, Maeda Y, Solante R, Hattori T
- Journal Title
  
  Biomolecules
  
  Volume: 10 Issue: 11 Pages: 1495-1495
- DOI
  10.3390/biom10111495
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08932, KAKENHI-PROJECT-17H01690
[Journal Article] Stimulation of THP-1 Macrophages with LPS Increased the Production of Osteopontin-Encapsulating Exosome2020
- Author(s)
  Bai Gaowa、Matsuba Takashi、Niki Toshiro、Hattori Toshio
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21(22) Issue: 22 Pages: 8490-8490
- DOI
  10.3390/ijms21228490
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01690
[Journal Article] Plasma Osteopontin Levels is Associated with Biochemical Markers of Kidney Injury in Patients with Leptospirosis2020
- Author(s)
  Chagan-Yasutan Haorile、Hanan Firmanto、Niki Toshiro、Bai Gaowa、Ashino Yugo、Egawa Shinichi、Telan Elizabeth Freda O.、Hattori Toshio
- Journal Title
  
  Diagnostics
  
  Volume: 10(7) Issue: 7 Pages: 439-439
- DOI
  10.3390/diagnostics10070439
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01690
[Journal Article] Galectin-9 Mediates HIV Transcription by Inducing TCR-Dependent ERK Signaling2019
- Author(s)
  Colomb F, Giron LB, Premeaux TA, Mitchell BI, Niki T, Papasavvas E, Montaner LJ, Ndhlovu LC, Abdel-Mohsen M
- Journal Title
  
  Front Immunol
  
  Volume: 10 Pages: 267-278
- DOI
  10.3389/fimmu.2019.00267
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01690, KAKENHI-PROJECT-16K08320
[Journal Article] Galectin-9 Changes Its Function to Maintain Homeostasis2018
- Author(s)
  Hirashima Mitsuomi、Niki Toshiro、Masaki Tsutomu
- Journal Title
  
  Trends in Glycoscience and Glycotechnology
  
  Volume: 30 Issue: 172 Pages: SJ55-SJ64
- DOI
  10.4052/tigg.1741.1SJ
- NAID
  130006319061
- ISSN
  0915-7352, 1883-2113
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08320
[Journal Article] Lgals9 deficiency attenuates nephritis and arthritis in pristane-induced lupus model of BALB/c mice2018
- Author(s)
  Zeggar S, Watanabe KS, Teshigawara S, Hiramatsu S, Katsuyama T, Katsuyama E, Watanabe H, Matsumoto Y, Kawabata T, Sada KE, Niki T, Hirashima M, Wada J.
- Journal Title
  
  Arthritis Rheumatol.
  
  Volume: - Issue: 7 Pages: 1089-1101
- DOI
  10.1002/art.40467
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09976, KAKENHI-PROJECT-16K08320
[Journal Article] Characterization of neutralizing antibodies reacting with the 213-224 amino-acid segment of human galectin-92018
- Author(s)
  Lhuillier C, Barjon C, Baloche V, Niki T, Gelin A, Mustapha R, Claer L, Hoos S, Chiba Y, Ueno M, Hirashima M, Wei M, Morales O, Raynal B, Delhem N, Dellis O, Busson P
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 9 Pages: 1-23
- DOI
  10.1371/journal.pone.0202512
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01690, KAKENHI-PROJECT-16K08320
[Journal Article] Plasma Galectin-9 Concentrations in Normal and Diseased Conditions2018
- Author(s)
  Niki T, Fujita K,Rosen H, Hirashima M, Masaki T, Hattori T, Hoshino K.
- Journal Title
  
  Cell Physiol Biochem
  
  Volume: 50 Issue: 5 Pages: 1856-1868
- DOI
  10.1159/000494866
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01690, KAKENHI-PROJECT-16K08320
[Journal Article] Galectin-9 as a Predictive Marker for the Onset of Immune-Related Adverse Effects Associated with Anti-CCR4 MoAb Therapy in Patients with Adult T Cell Leukemia2017
- Author(s)
  Mohamed TC, Chagana-Yasutan H, Ashino Y, Nakayama W, Suzushima H, Hattori T
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 241 Issue: 3 Pages: 201-208
- DOI
  10.1620/tjem.241.201
- NAID
  130005461075
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26257506, KAKENHI-PROJECT-16K08320
[Journal Article] Secretion of IFN-γ Associated with Galectin-9 Production by Pleural Fluid Cells from a Patient with Extrapulmonary Tuberculosis.2017
- Author(s)
  Zhao J, Shiratori B, Chagan-Yasutan H, Matsumoto M, Niki T, Tanaka M, Takahashi Y, Usami O, Ashino Y, Hattori T.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 18 Issue: 7 Pages: 1382-1382
- DOI
  10.3390/ijms18071382
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01690
[Journal Article] Acute Liver Failure Study Group. Association Between Plasma Level of Galectin-9 and Survival of Patients With Drug-Induced Acute Liver Failure.2016
- Author(s)
  Rosen HR, Biggins SW, Niki T, Gralla J, Hillman H, Hirashima M, Schilsky M, Lee WM
- Journal Title
  
  Clin Gastroenterol Hepatol
  
  Volume: 14 Issue: 4 Pages: 606-612
- DOI
  10.1016/j.cgh.2015.09.040
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460592, KAKENHI-PROJECT-26257506, KAKENHI-PROJECT-16K08320
[Journal Article] Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation.2016
- Author(s)
  Abdel-Mohsen M, Chavez L, Tandon R, Chew GM, Deng X, Danesh A, Keating S, Lanteri M, Samuels ML, Hoh R, Sacha JB, Norris PJ, Niki T, Shikuma CM, Hirashima M, Deeks SG, Ndhlovu LC, Pillai SK.
- Journal Title
  
  PLoS Pathog.
  
  Volume: 12(6） Issue: 6 Pages: e1005677-e1005677
- DOI
  10.1371/journal.ppat.1005677
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26257506, KAKENHI-PROJECT-16K08320
[Journal Article] Development of Point-of-Care Testing for Disaster-Related Infectious Diseases2016
- Author(s)
  Hattori T, Chagan-Yasutan H, Shiratori B, Egawa S, Izumi T, Kubo T, Nakajima C, Suzuki Y, Niki T, Alisjahbana B, Telan E.
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 238 Issue: 4 Pages: 287-293
- DOI
  10.1620/tjem.238.287
- NAID
  130005138757
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460592
[Journal Article] Plasma levels of Galectin-9 reflect disease severity in malaria infection2016
- Author(s)
  Dembele BP, Chagan-Yasutan H, Niki T, Ashino Y, Tangpukdee N, Shinichi E, Krudsood S, Kano S, Hattori T
- Journal Title
  
  Malaria J
  
  Volume: 15 Pages: 403-403
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26257506
[Journal Article] Plasma levels of Galectin-9 reflect disease severity in malaria infection.2016
- Author(s)
  Dembele BP, Chagan-Yasutan H, Niki T, Ashino Y, Tangpukdee N, Shinichi E, Krudsood S, Kano S, Hattori T.
- Journal Title
  
  Malar J.
  
  Volume: 15 Issue: 1 Pages: 403-403
- DOI
  10.1186/s12936-016-1471-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08320
[Journal Article] Galectin-9: An anticancer molecule for gallbladder carcinoma.2016
- Author(s)
  Tadokoro T, Morishita A, Fujihara S, Iwama H, Niki T, Fujita K, Akashi E, Mimura S, Oura K, Sakamoto T, Nomura T, Tani J, Miyoshi H, Yoneyama H, Himoto T, Hirashima M, Masaki T.
- Journal Title
  
  Int J Oncol
  
  Volume: 48 Issue: 3 Pages: 1165-1174
- DOI
  10.3892/ijo.2016.3347
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460592, KAKENHI-PROJECT-16K09361
[Journal Article] Galectin-9 suppresses the proliferation of gastric cancer cells in vitro.2016
- Author(s)
  Takano J, Morishita A, Fujihara S, Iwama H, Kokado F, Fujikawa K, Fujita K, Chiyo T, Tadokoro T, Sakamoto T, Nomura T, Tani J, Miyoshi H, Yoneyama H, Kobara H, Mori H, Niki T, Hirashima M, Masaki T.
- Journal Title
  
  Oncol Rep
  
  Volume: 35 Issue: 2 Pages: 851-860
- DOI
  10.3892/or.2015.4452
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460592, KAKENHI-PROJECT-16K09361
[Journal Article] Effect of nasopharyngeal carcinoma-derived exosomes on human regulatory T cells.2015
- Author(s)
  Mrizak D, Martin N, Barjon C, Jimenez-Pailhes AS, Mustapha R, Niki T, Guigay J, Pancré V, de Launoit Y, Busson P, Moralès O, Delhem N.
- Journal Title
  
  J Natl Cancer Inst.
  
  Volume: 107 Issue: 1 Pages: 1-13
- DOI
  10.1093/jnci/dju363
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460592
[Journal Article] Impact of Exogenous Galectin-9 on Human T Cells: CONTRIBUTION OF THE T CELL RECEPTOR COMPLEX TO ANTIGEN-INDEPENDENT ACTIVATION BUT NOT TO APOPTOSIS INDUCTION.2015
- Author(s)
  Lhuillier C, Barjon C, Niki T, Gelin A, Praz F, Morales O, Souquere S, Hirashima M, Wei M, Dellis O, Busson P.
- Journal Title
  
  J Biol Chem
  
  Volume: 290 Issue: 27 Pages: 16797-16811
- DOI
  10.1074/jbc.m115.661272
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460592
[Journal Article] The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux.2015
- Author(s)
  Wiersma VR, de Bruyn M, Wei Y, van Ginkel RJ, Hirashima M, Niki T, Nishi N, Zhou J, Pouwels SD, Samplonius DF, Nijman HW, Eggleton P, Helfrich W, Bremer E.
- Journal Title
  
  Autophagy
  
  Volume: 11 Issue: 8 Pages: 1373-1388
- DOI
  10.1080/15548627.2015.1063767
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460592
[Journal Article] Galectin-9 suppresses the growth of hepatocellular carcinoma via apoptosis in vitro and in vivo.2015
- Author(s)
  Fujita K, Iwama H, Sakamoto T, Okura R, Kobayashi K, Takano J, Katsura A, Tatsuta M, Maeda E, Mimura S, Nomura T, Tani J, Miyoshi H, Morishita A, Yoneyama H, Yamana Y, Himoto T, Okano K, Suzuki Y, Niki T, Hirashima M, Masaki T.
- Journal Title
  
  Int J Oncol.
  
  Volume: 46 Issue: 6 Pages: 2419-2430
- DOI
  10.3892/ijo.2015.2941
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460592, KAKENHI-PROJECT-25460998
[Journal Article] The protective function of galectin-9 in liver ischemia and reperfusion injury in mice.2015
- Author(s)
  Hirofumi Hirao, Yoichiro Uchida, Kentaro Kadono, Hirokazu Tanaka, Toshiro Niki, Akira Yamauchi, Koichiro Hata, Takeshi Watanabe, Hiroaki Terajima, Shinji Uemoto
- Journal Title
  
  Liver Transplantation
  
  Volume: 21 Issue: 7 Pages: 969-981
- DOI
  10.1002/lt.24159
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K10177, KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-25460592, KAKENHI-PROJECT-25670590, KAKENHI-PLANNED-24111009
[Journal Article] MicroRNA profiles following metformin treatment in a mouse model of non-alcoholic steatohepatitis.2015
- Author(s)
  Katsura A, Morishita A, Iwama H, Tani J, Sakamoto T, Tatsuta M, Toyota Y, Fujita K, Kato K, Maeda E, Nomura T, Miyoshi H, Yoneyama H, Himoto T, Fujiwara S, Kobara H, Mori H, Niki T, Ono M, Hirashima M, Masaki T.
- Journal Title
  
  Int J Mol Med
  
  Volume: 35 Issue: 4 Pages: 877-884
- DOI
  10.3892/ijmm.2015.2092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460592
[Journal Article] Evaluation of matricellular proteins in systemic and local immune response to Mycobacterium tuberculosis infection.2015
- Author(s)
  Hasibuan FM, Shiratori B, Senoputra MA, Chagan-Yasutan H, Koesoemadinata RC, Apriani L, Takahashi Y, Niki T, Alisjahbana B, Hattori T.
- Journal Title
  
  Microbiol Immunol
  
  Volume: 59 Issue: 10 Pages: 623-632
- DOI
  10.1111/1348-0421.12320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460592
[Journal Article] Galectin-9 suppresses cholangiocarcinoma cell proliferation by inducing apoptosis but not cell cycle arrest.2015
- Author(s)
  Kobayashi K, Morishita A, Iwama H, Fujita K, Okura R, Fujihara S, Yamashita T, Fujimori T, Kato K, Kamada H, Niki T, Hirashima M, Okano K, Suzuki Y, Masaki T.
- Journal Title
  
  Oncol Rep
  
  Volume: 34 Issue: 4 Pages: 1761-1770
- DOI
  10.3892/or.2015.4197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460592
[Journal Article] Galectin-9 enhances cytokine secretion, but suppresses survival and degranulation, in human mast cell line2014
- Author(s)
  Kojima R, Ohno T, Iikura M, Niki T, Hirashima M, Iwaya K, Tsuda H, Nonoyama S, Matsuda A, Saito H, Matsumoto K, Nakae S
- Journal Title
  
  PLoS ONE
  
  Volume: 9 Issue: 1 Pages: e86106-e86106
- DOI
  10.1371/journal.pone.0086106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390262, KAKENHI-PROJECT-23591666, KAKENHI-PROJECT-25460592, KAKENHI-PROJECT-25670484, KAKENHI-PROJECT-26257506
[Journal Article] Galectin-9 ameliorates anti-GBM glomerulonephritis by inhibiting Th1 and Th17 immune responses in mice.2014
- Author(s)
  Zhang Q, Luan H, Wang L, He F, Zhou H, Xu X, Li X, Xu Q, Niki T, Hirashima M, Xu G, Lv Y, Yuan J.
- Journal Title
  
  Am J Physiol Renal Physiol.
  
  Volume: 306 Issue: 8 Pages: F822-F832
- DOI
  10.1152/ajprenal.00294.2013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460592
[Journal Article] Galectin-9 controls the therapeutic activity of 4-1BB-targeting antibodies.2014
- Author(s)
  Madireddi S, Eun SY, Lee SW, Nemčovičová I, Mehta AK, Zajonc DM, Nishi N, Niki T, Hirashima M, Croft M.
- Journal Title
  
  J Exp Med.
  
  Volume: 211 Issue: 7 Pages: 1433-1448
- DOI
  10.1084/jem.20132687
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460592, KAKENHI-PROJECT-26257506
[Journal Article] Elevated OPN, IP-10, and neutrophilia in loop-mediated isothermal amplification confirmed tuberculosis patients.2014
- Author(s)
  Shiratori B, Leano S, Nakajima C, Chagan-Yasutan H, Niki T, Ashino Y, Suzuki Y, Telan E, Hattori T.
- Journal Title
  
  Mediators Inflamm.
  
  Volume: 2014 Pages: 1-8
- DOI
  10.1155/2014/513263
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460592, KAKENHI-PROJECT-26257506
[Journal Article] Galectin-9 is rapidly released during acute HIV-1 infection and remains sustained at high levels despite viral suppression even in elite controllers.2014
- Author(s)
  Tandon R, Chew GM, Byron MM, Borrow P, Niki T, Hirashima M, Barbour JD, Norris PJ, Lanteri MC, Martin JN, Deeks SG, Ndhlovu LC.
- Journal Title
  
  AIDS Res Hum Retroviruses.
  
  Volume: 30 Issue: 7 Pages: 654-664
- DOI
  10.1089/aid.2014.0004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460592
[Journal Article] Galectin-9 functionally impairs natural killer cells in humans and mice.2013
- Author(s)
  Golden-Mason L1, McMahan RH, Strong M, Reisdorph R, Mahaffey S, Palmer BE, Cheng L, Kulesza C, Hirashima M, Niki T, Rosen HR.
- Journal Title
  
  J Virol
  
  Volume: 87(9): Issue: 9 Pages: 4835-4845
- DOI
  10.1128/jvi.01085-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23256004, KAKENHI-PROJECT-25460592
[Journal Article] Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3.2013
- Author(s)
  Moritoki M, Kadowaki T, Niki T, Nakano D, Soma G, Mori H, Kobara H, Masaki T, Kohno M, Hirashima M.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 4 Pages: e60807-e60807
- DOI
  10.1371/journal.pone.0060807
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460592
[Journal Article] Galectin-9 activates and expands human T-helper 1 cells.2013
- Author(s)
  Gooden MJ1, Wiersma VR, Samplonius DF, Gerssen J, van Ginkel RJ, Nijman HW, Hirashima M, Niki T, Eggleton P, Helfrich W, Bremer E.
- Journal Title
  
  PLoS One
  
  Volume: 8(5) Issue: 5 Pages: e65616-e65616
- DOI
  10.1371/journal.pone.0065616
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23256004, KAKENHI-PROJECT-25460592
[Journal Article] Preventive effect of galectin-9 on double-stranded RNA-induced airway hyperresponsiveness in an exacerbation model of mite antigen-induced asthma in mice.2013
- Author(s)
  Katoh S, Shimizu H, Obase Y, Oomizu S, Niki T, Ikeda M, Mouri K, Kobashi Y, Hirashima M, Oka M.
- Journal Title
  
  Exp Lung Res
  
  Volume: 39 Issue: 10 Pages: 453-462
- DOI
  10.3109/01902148.2013.850558
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460592
[Journal Article] Galectin-9 prolongs the survival of septic mice by expanding Tim-3-expressing natural killer T cells and PDCA-1+ CD11c+ macrophages2013
- Author(s)
  Kadowaki T, Morishita A, Niki T, Hara J, Sato M, Tani J, Miyoshi H, Yoneyama H, Masaki T, Hattori T, Matsukawa A, Hirashima M.
- Journal Title
  
  Crit Care
  
  Volume: 17(6) Issue: 6
- DOI
  10.1186/cc13147
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23256004, KAKENHI-PROJECT-25460998
[Journal Article] Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection2013
- Author(s)
  Chagan-Yasutan H1, Ndhlovu LC, Lacuesta TL, Kubo T, Leano PS, Niki T, Oguma S, Morita K, Chew GM, Barbour JD, Telan EF, Hirashima M, Hattori T, Dimaano EM.
- Journal Title
  
  J Clin Virol
  
  Volume: 58(4) Issue: 4 Pages: 635-640
- DOI
  10.1016/j.jcv.2013.10.022
- NAID
  120006986004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23256004, KAKENHI-PROJECT-25460592
[Journal Article] Galectin-9 Ameliorates Clinical Severity of MRL/lpr Lupus-Prone Mice by Inducing Plasma Cell Apoptosis Independently of Tim-3.2013
- Author(s)
  Moritoki M, Kadowaki T, Niki T, Nakano D, Soma G, Mori H, Kobara H, Masaki T, Kohno M, Hirashima M.
- Journal Title
  
  PLoS One
  
  Volume: 8
- Data Source
  KAKENHI-PROJECT-22590360
[Journal Article] Cis association of galectin-9 with Tim-3 differentially regulates IL-12/IL-23 expressions in monocytes via TLR signaling2013
- Author(s)
  Ma CJ1, Li GY, Cheng YQ, Wang JM, Ying RS, Shi L, Wu XY, Niki T, Hirashima M, Li CF, Moorman JP, Yao ZQ
- Journal Title
  
  PLoS One
  
  Volume: 8(8) Issue: 8 Pages: e72488-e72488
- DOI
  10.1371/journal.pone.0072488
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23256004, KAKENHI-PROJECT-25460592
[Journal Article] HCV-infected hepatocytes drive CD4+ CD25+ Foxp3+ regulatory T-cell development through the Tim-3/Gal-9 pathway.2013
- Author(s)
  Ji XJ, Ma CJ, Wang JM, Wu XY, Niki T,Hirashima M, Moorman JP, Yao ZQ
- Journal Title
  
  Eur J Immunol.
  
  Volume: 43 Pages: 458-67
- Data Source
  KAKENHI-PROJECT-22590360
[Journal Article] Galectin-9 in combination with rapamycin induces cardiac allograft tolerance in mice.2013
- Author(s)
  Cai L, Zhou H, Fang Z, Yuan J, Niki T, Hirashima M, He W, Chen ZK.
- Journal Title
  
  Transplantation
  
  Volume: 96 Issue: 4 Pages: 379-386
- DOI
  10.1097/tp.0b013e31829b07b5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460592
[Journal Article] Galectin-9 in cancer therapy. Recent Pat Endocr Metab Immune Drug Discov.2013
- Author(s)
  Fujihara S, Mori H, Kobara H, Rafiq K, Niki T, Hirashima M, Masaki T.
- Journal Title
  
  Recent Pat Endocr Metab Immune Drug Discov
  
  Volume: 7 Pages: 130-137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460592
[Journal Article] Galectin-9 prolongs the survival of septic mice by expanding tim-3-expressing natural killer T cells and PDCA-1+ CD11c+ macrophages.2013
- Author(s)
  Kadowaki T, Morishita A, Niki T, Hara J, Sato M, Tani J, Miyoshi H, Yoneyama H, Masaki T, Hattori T, Matsukawa A, Hirashima M.
- Journal Title
  
  Crit Care
  
  Volume: 17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460592
[Journal Article] Galectin-9 in cancer therapy2013
- Author(s)
  Fujihara S, Mori H, Kobara H, Rafiq K, Niki T, Hirashima M, Masaki T.
- Journal Title
  
  Recent Pat Endocr Metab Immune Drug Discov
  
  Volume: 7 Pages: 130-7
- Data Source
  KAKENHI-PROJECT-22590360
[Journal Article] Galectin-9 functionally impairs natural killer cells in humans and mice.2013
- Author(s)
  Golden-Mason L, McMahan RH, Strong M, Reisdorph R, Mahaffey S, Palmer BE, Cheng L, Kulesza C, Hirashima M, Niki T, Rosen HR.
- Journal Title
  
  J Virol
  
  Volume: 87 Pages: 4838-45
- Data Source
  KAKENHI-PROJECT-22590360
[Journal Article] Galectin-9 ameliorates herpes simplex-induced inflammation through apoptosis2012
- Author(s)
  Shim JA, Park S, Lee ES, Niki T, Hirashima M, Sohn S
- Journal Title
  
  Immunobiology
  
  Volume: 217 Pages: 657-66
- Data Source
  KAKENHI-PROJECT-22590360
[Journal Article] Galectin-9 signaling prolongs survival in murine lung-cancer by inducing macrophages to differentiate into plasmacytoid dendritic cell-like macrophages.2012
- Author(s)
  Kadowaki T, Arikawa T, Shinonaga R, Oomizu S, Inagawa H, Soma G, Niki T, Hirashima M
- Journal Title
  
  Clin Immunol
  
  Volume: 142 Pages: 296-307
- Data Source
  KAKENHI-PROJECT-22590360
[Journal Article] A novel monoclonal antibody fordetection ofgalectin-9 intissue sections: application tohuman tissues infected byoncogenic viruses.2012
- Author(s)
  Barjon C, Niki T, Verillaud B, Opolon P, Bedossa P,Hirashima M, Blanchin S, Wassef M, Rosen HR, Jimenez AS, Wei M, Busson P
- Journal Title
  
  Infect Agent Cancer
  
  Volume: 7 Pages: 16-16
- Data Source
  KAKENHI-PROJECT-22590360
[Journal Article] Galectin-9 binding to Tim-3 renders activated human CD4+ T cells less susceptible to HIV-1 infection2012
- Author(s)
  Shokrollah Elahi, Toshiro Niki, Mitsuomi Hirashima, Helen Horton
- Journal Title
  
  Blood
  
  Volume: (未定)(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23256004
[Journal Article] Cell surface galectin-9 expressing th cells regulate Th17 and Foxp3+ Treg development by galectin-9 secretion2012
- Author(s)
  Oomizu S, Arikawa T, Niki T, Kadowaki T, Ueno M, Nishi N, Yamauchi A, Hattori T, Masaki T, Hirashima M.
- Journal Title
  
  PLoS One
  
  Volume: 7
- Data Source
  KAKENHI-PROJECT-22590360
[Journal Article] IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma2012
- Author(s)
  Yang ZZ
- Journal Title
  
  J Clin Invest
  
  Volume: 2;122(4) Issue: 4 Pages: 1271-82
- DOI
  10.1172/jci59806
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590360, KAKENHI-PROJECT-23256004
[Journal Article] Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner2012
- Author(s)
  Oomizu S
- Journal Title
  
  Clin Immunol
  
  Volume: 143(1) Issue: 1 Pages: 51-8
- DOI
  10.1016/j.clim.2012.01.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590360, KAKENHI-PROJECT-22590958, KAKENHI-PROJECT-23256004, KAKENHI-PROJECT-23591438
[Journal Article] IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma2012
- Author(s)
  ZZ. Yang, DM. Grote, SC. Ziesmer, T. Niki, M. Hirashima, AJ. Novak, TE. Wizig, SM. Ansell.
- Journal Title
  
  J. Clin Invest
  
  Volume: 122 Pages: 1271-82
- Data Source
  KAKENHI-PROJECT-22590360
[Journal Article] Possible regulatory role of galectin-9 on Ascaris suum-induced eosinophilic lung inflammation in mice2012
- Author(s)
  S. Katoh, S. Oomizu, T. Niki, H. Shimizu, Y. Obase, M. Korenga, M. Oka, M. Hirashima
- Journal Title
  
  International Archives of Allergy and Immunology
  
  Volume: 158(Suppl. 1) Issue: Suppl. 1 Pages: 58-65
- DOI
  10.1159/000337769
- Data Source
  KAKENHI-PROJECT-23591438
[Journal Article] Galectin-9 signaling prolongs survival in murine lung-cancer by inducing macrophages to differentiate into plasmacytoid dendritic cell-like macrophages2012
- Author(s)
  Kadowaki T
- Journal Title
  
  Clin Immunol
  
  Volume: 142(3) Issue: 3 Pages: 296-307
- DOI
  10.1016/j.clim.2011.11.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590360, KAKENHI-PROJECT-23256004, KAKENHI-PROJECT-23591438
[Journal Article] Galectin-9 ameliorates herpes simplex virus-induced inflammation through apoptosis2012
- Author(s)
  Shim JA
- Journal Title
  
  Immunobiology
  
  Volume: 217(6) Issue: 6 Pages: 657-66
- DOI
  10.1016/j.imbio.2011.11.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590360, KAKENHI-PROJECT-23256004
[Journal Article] TNFRSF25 Agonistic Antibody andGalectin-9 Combination Therapy Controls Herpes Simplex Virus-Induced Immunoinflammatory Lesions.2012
- Author(s)
  J Reddy PB, Schreiber TH, Rajasagi NK, Suryawanshi A, Mulik S, Veiga-Parga T, Niki T, Hirashima M, Podack ER, Rouse BT
- Journal Title
  
  J Virol
  
  Volume: 86 Pages: 10606-20
- Data Source
  KAKENHI-PROJECT-22590360
[Journal Article] Galectin-9 binding to Tim-3 renders activated human CD4+ T cells less susceptible to HIV-1 infection2012
- Author(s)
  S. Elahi, T. Niki, M. Hirashima, H. Horton.
- Journal Title
  
  Blood
  
  Volume: 120 Pages: 682-90
- Data Source
  KAKENHI-PROJECT-22590360
[Journal Article] Rapid Decrease ofPlasma Galectin-9 Levels inPatients with Acute HIVInfection after Therapy2012
- Author(s)
  Saitoh H, Ashino Y, Chagan-Yasutan H, Niki T, Hirashima M, Hattori T.
- Journal Title
  
  Tohoku J Exp Med
  
  Volume: 228 Pages: 157-61
- Data Source
  KAKENHI-PROJECT-22590360
[Journal Article] Tim-3 is an inducible human NK cell receptor that enhances interferon gamma production in response to galectin-92012
- Author(s)
  MK. Gleason, TR. Lenvik, V. McCullar, M.Felices, MS. O'Brien, SA. Cooley, MR. Verneris, F. Cichocki, CJ. Holman, A.Panoskaltsis-Mortari, T. Niki, M.Hirashima, B.R. Blazar, JS. Miller
- Journal Title
  
  Blood
  
  Volume: 119 Pages: 3064-72
- Data Source
  KAKENHI-PROJECT-22590360
[Journal Article] Cell surface galectin-9 expressing Th cells regulate Th17 and Foxp3+ Treg development by galectin-9 secretion.2012
- Author(s)
  Oomizu S, Arikawa T, Niki T, Kadowaki T, Ueno M, Nishi N, Yamauchi A, Hattori T, Masaki T, Hirashima M.
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 11 Pages: 1-10
- DOI
  10.1371/journal.pone.0048574
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590958, KAKENHI-PROJECT-23256004, KAKENHI-PROJECT-23591438
[Journal Article] The glycan-binding protein Galectin-9 has direct apoptotic activity towards melanoma cells2012
- Author(s)
  Wiersma VR, de Bruyn M, van Ginkel RJ, Sigar E, HirashimaM, Niki T, Nishi N, Samplonius DF, Helfrich W, Bremer E.
- Journal Title
  
  J Invest Dermatol
  
  Volume: 132 Pages: 2302-5
- Data Source
  KAKENHI-PROJECT-22590360
[Journal Article] Tim-3 is an inducible human NK cell receptor that enhances interferon gamma production in response to galectin-92012
- Author(s)
  Gleason MK
- Journal Title
  
  Blood
  
  Volume: (印刷中) Issue: 13 Pages: 3064-72
- DOI
  10.1182/blood-2011-06-360321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590360, KAKENHI-PROJECT-23256004
[Journal Article] Galectin-9 attenuates acute lung injury by expanding CD14- plasmacytoid dendritic cell-like macrophages.2011
- Author(s)
  Kojima K, Arikawa T, Saita N, Goto E, Tsumura S, Tanaka R, Masunaga A, Niki T, Oomizu S, Hirashima M, Kohrogi H.
- Journal Title
  
  Am J Respir Crit Care Med
  
  Volume: 184 Pages: 328-39
- Data Source
  KAKENHI-PROJECT-22590360
[Journal Article] Galectin-9 Attenuates Acute Lung Injury by Expanding CD14^- Plasmacytoid Dendritic Cell-Like Macrophages2011
- Author(s)
  K. Kojima, T. Arikawa, N. Saita, E. Goto, Tsumura, R. Tanaka, A. Masunaga, T. Niki, S. Oomizu, M. Hirashima, H. Kohrogi
- Journal Title
  
  American journal of respiratory and critical care medicine
  
  Volume: 184(3) Issue: 3 Pages: 328-39
- DOI
  10.1164/rccm.201010-1566oc
- Data Source
  KAKENHI-PROJECT-23591438
[Journal Article] Endogenous galectin-1 and acute inflammation: emerging notion of a galectin-9 pro-resolving effect.2011
- Author(s)
  Iqbal AJ, Sampaio AL, Maione F, Greco KV, Niki T, Hirashima M, Perretti M, Cooper D.
- Journal Title
  
  Am. J. Pathol.
  
  Volume: 178 Pages: 1201-9
- Data Source
  KAKENHI-PROJECT-22590360
[Journal Article] Galectin-9 administration ameliorates CVB3 induced myocarditis by promoting the proliferation of regulatory T cells and alternatively activated Th2 cells2011
- Author(s)
  Lv K
- Journal Title
  
  Clin Immunol
  
  Volume: 140 Issue: 1 Pages: 92-101
- DOI
  10.1016/j.clim.2011.03.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590360, KAKENHI-PROJECT-23256004
[Journal Article] Galectin-9 administration ameliorates CVB3 induced myocarditis by promoting the proliferation of regulatory T cells and alternatively activated Th2 cells.2011
- Author(s)
  Lv K, Xu W, Wang C, Niki T, Hirashima M, Xiong S.
- Journal Title
  
  Clin Immunol
  
  Volume: 140 Pages: 92-101
- Data Source
  KAKENHI-PROJECT-22590360
[Journal Article] Endogenous galectin-1 and acute inflammation : emerging notion of a galectin-9 pro-resolving effect2011
- Author(s)
  Iqbal AJ
- Journal Title
  
  Am.J.Pathol.
  
  Volume: 178 Issue: 3 Pages: 1201-1209
- DOI
  10.1016/j.ajpath.2010.11.073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590360, KAKENHI-PROJECT-23256004
[Journal Article] Galectin-9 attenuates acute lung injury by expanding CD14-plasmacytoid dendritic cell-like macrophages2011
- Author(s)
  Kojima K, Arikawa T, Saita N, Goto E, Tsumura S, Tanaka R, Masunaga A, Niki T, Oomizu S, Hirashima M, Kohrogi H
- Journal Title
  
  Am J Respir Crit Care Med
  
  Volume: 184 Pages: 328-339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23256004
[Journal Article] Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways.2011
- Author(s)
  Vega-Carrascal I, Reeves EP, Niki T, Arikawa T, McNally P, O'Neill SJ, Hirashima M, McElvaney NG.
- Journal Title
  
  J. Immunol.
  
  Volume: 186 Pages: 2897-909
- Data Source
  KAKENHI-PROJECT-22590360
[Journal Article] Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways2011
- Author(s)
  Vega-Carrascal I
- Journal Title
  
  J.Immunol.
  
  Volume: 186 Issue: 5 Pages: 2897-2909
- DOI
  10.4049/jimmunol.1003187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590360, KAKENHI-PROJECT-23256004
[Journal Article] A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in chronic hepatitis C infection.2010
- Author(s)
  John A. Mengshol, Lucy Golden-Mason, Tomohiro Arikawa, Maxwell Smith, Toshiro Niki, Ryan McWilliams, Jessica Randall, Rachel McMahan, Manu Rangachari, Evgenia Dobrinskikh, Pierre Busson, Stephen J. Polyak, Mitsuomi Hirashima, Hugo R. Rosen.
- Journal Title
  
  Plos One
  
  Volume: 5(3)
- Data Source
  KAKENHI-PROJECT-22590360
[Journal Article] Galectin-9 trafficking regulates apical-basal polarity in Madin-Darby canine kidney epithelial cells.2010
- Author(s)
  Rashmi Mishra, Michal Grzybek, Toshiro Niki, Mitsuomi Hirashima, Kai Simons.
- Journal Title
  
  PNAS
  
  Volume: 107 (41) Pages: 17633-38
- Data Source
  KAKENHI-PROJECT-22590360
[Journal Article] Determination of carbohydratebinding preferences of human galectins with carbohydrate microarrays.2010
- Author(s)
  T.Horlacher, M A. Oberli, DB. Werz, LH. Krock, S. Bufali, B. Stocker, R. Mishra, J. Sobek, K. Simons, M. Hirashima, T. Niki, PH. Seeberger.
- Journal Title
  
  ChemBioChem
  
  Volume: 11 Pages: 1563-73
- Data Source
  KAKENHI-PROJECT-22590360
[Patent] GALECTIN MOLECULES AS IMMUNOTHERAPY TARGETS.2018
- Inventor(s)
  Ndhlovu L and Niki T.
- Industrial Property Rights Holder
  Ndhlovu L and Niki T.
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-16K08320
[Patent] ガレクチン9を分泌する細胞、その製造方法及びその用途2011
- Inventor(s)
  有川智広、平島光臣、門脇健、仁木敏朗、大水総一
- Industrial Property Rights Holder
  株式会社ガルファーマ
- Industrial Property Rights Type
  特許
- Filing Date
  2011-12-09
- Overseas
- Data Source
  KAKENHI-PROJECT-23591438
[Presentation] Novel methods to overcome disaster and tropical infectious diseases2020
- Author(s)
  Toshio Hattori, Toshiro Niki, Gaowa Bai, Nobuyuki Kobayashi, Takahiro Haruyama and Haruhisa Kikuchi
- Organizer
  Sci Tech Infectious Disease 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01690
[Presentation] Detection of degraded form of matricellular proteins in vitro and in vivo2018
- Author(s)
  Toshio Hattori, Gaowa Bai, Hirotoshi Motoda, Takashi Matsuba, Toishiro Niki
- Organizer
  JITMM 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01690
[Presentation] Galectin-9 may play as PRR in Dengue Virus Infection2016
- Author(s)
  Chagan-Yasutan H，Labayo HK, Niki T, Hattori T
- Organizer
  第１１回　日中ウイルス学会
- Place of Presentation
  観音寺
- Year and Date
  2016-07-01
- Data Source
  KAKENHI-PROJECT-26257506
[Presentation] 57.Plasma Galectin-9 is Associated with T-reg Proportion and Th1/Th2 ratio in Severe Septic Patient.2015
- Author(s)
  Haorile Chagan-Yasutan, Satoshi Yamanouchi, Daisuke Kudo, Toshiro Niki, Yugo Ashino, Shigeki Kushimoto, Toshio Hattor
- Organizer
  第７７回日本血液学会
- Place of Presentation
  金沢
- Year and Date
  2015-10-03
- Data Source
  KAKENHI-PROJECT-26257506
[Presentation] Potential functions of galectin-9 in mucosal immunity.2015
- Author(s)
  Niki T, Fukunaga H, Natori T, Hara A,Takeda K, Ezaki T.
- Organizer
  日本細菌学会国際シンポジウム
- Place of Presentation
  長良川国際会議場
- Year and Date
  2015-03-26
- Data Source
  KAKENHI-PROJECT-25460592
[Presentation] Galectin-9は重症敗血症の免疫・炎症反応に関連する可能性がある。2015
- Author(s)
  浩日勒、山内聡、工藤大介、仁木敏朗、芦野有悟、服部俊夫、久志本成樹
- Organizer
  第19回エンドトキシン血症救命治療研究会
- Place of Presentation
  仙台
- Year and Date
  2015-01-23
- Data Source
  KAKENHI-PROJECT-26257506
[Presentation] Inflammatory Profiles of Dengue Virus Infection.2013
- Author(s)
  Haorile Chagan-Yasutan, Talitha Lea Lacuesta, Lishomwa C. Ndhlovu, Prisca Susan A. Leano, Elizabeth Freda O.Telan, Toshiro Niki, Mitsuomi Hirashima, Efren M. Dimaano and Toshio Hattori.
- Organizer
  海外学術調査フェスタ
- Place of Presentation
  東京外国語大学
- Year and Date
  2013-06-29
- Data Source
  KAKENHI-PROJECT-23256004
[Presentation] Anti-TBGL IgA antibody suggest mucosal immunity involvement in latent tuberculosis in fection,which is frequently positive for anti-TBGL-IgG antibody2012
- Author(s)
  Haorile Chagan-Yasutan, Lishomwa C. Ndhlovu, Talitha Lea Lacuesta, Prisca Susan A. Leano, Elizabeth Freda O.Telan, Toshiro Niki, Mitsuomi Hirashima, Efren M. Dimaano and Toshio Hattori.
- Organizer
  IMMUNOLOGY 2012
- Place of Presentation
  ボストン, アメリカ
- Data Source
  KAKENHI-PROJECT-23256004
[Presentation] 安定化ガレクチン9の開発と自己免疫疾患モデルでの有効性2011
- Author(s)
  仁木敏朗
- Organizer
  国際バイオEXPO(バイオアカデミックフォーラム)
- Place of Presentation
  東京都
- Year and Date
  2011-07-01
- Data Source
  KAKENHI-PROJECT-23256004
[Presentation] Critical role of galectin-9 but not IL-10 from Type1 regulatory T cells to regulate T helper 17 cell development2011
- Author(s)
  大水総一, 仁木敏朗, 平島光臣, 他
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  千葉市
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-23256004
[Presentation] Critical role of galectin-9 but not IL-10 from Type1 regulatory T cells to regulate T helper 17 cell development2011
- Author(s)
  S. Oomizu, T. Arikawa, T. Niki, K. Kadowaki, N. Nishi, A. Yamauchi, M. Hirashima
- Organizer
  第40回日本免疫学会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23591438
[Presentation] 安定化ガレクチン9の開発と自己免疫疾患モデルでの有効性2011
- Author(s)
  仁木敏朗
- Organizer
  国際バイオEXPO(バイオアカデミックフォーラム)
- Place of Presentation
  東京ビッグサイト(東京都)
- Year and Date
  2011-07-01
- Data Source
  KAKENHI-PROJECT-22590360
[Presentation] Galectin-9 switches monocyte differentiation to plasmacytoid dendritic cell-like macrophages to prolong the survival of lung cancer-bearing2011
- Author(s)
  門脇健, 仁木敏朗, 平島光臣, 他
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  千葉市
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-23256004
[Presentation] Profiles of Pro-inflammatory and Anti-inflammatory Cytokine/Chemokines in Acute Dengue Virus Infection.
- Author(s)
  Haorile Chagan-Yasutan, Talitha Lea Lacuesta, Lishomwa C. Ndhlovu, Toru Kubo, Prisca Susan A. Leano, Toshiro Niki, Yugo Ashino, Jason D. Barbour, Elizabeth Freda O. Telan, Mitsuomi Hirashima, Efren M. Dimaano, Toshio Hattori. ,
- Organizer
  NIH-Tohoku University-JSPS International Symposium
- Place of Presentation
  仙台東北大学
- Year and Date
  2013-05-09 – 2013-05-10
- Data Source
  KAKENHI-PROJECT-23256004

1. HIRASHIMA Mitsuomi (70109700)

# of Collaborated Projects: 3 results

# of Collaborated Products: 36 results
2. HATTORI Toshio (30172935)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
3. HAORILE Chagan-Yasutan (50624821)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. OOMIZU Souichi (00444729)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
5. KUBO Toru (50444873)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. Masaki Tsutomu (30335848)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 江川新一 (00270679)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. 狩野繁之 (60233912)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. 小原英幹 (10612476)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 岩間久和 (20398035)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 藤田浩二 (50749421)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 田所智子 (50813177)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 森下朝洋 (60423430)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 大浦杏子 (80834639)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 児玉栄一 (50271151)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 元田弘敏 (30278999)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 川瀬三雄 (50108057)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 坂本鉄平 (30769328)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 野村貴子 (70645415)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 米山弘人 (80294750)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 谷丈二 (00596075)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 中原麻衣 (00865610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. Krudsood Srivicha

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. Telan Elizabeth

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. Alsijahbana Bachti

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. KAWABATA Tomoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. MATSUMOTO Kenji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. SAITO Hirohisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. NAKAE Susumu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. HIRAO Hirofumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. UENO Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 前田洋助

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 松葉隆司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 山内清明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 渡辺武

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 内田洋一朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Niki Toshiro 仁木 敏朗

NIKI Toshiro 仁木 敏朗

Research Projects

Research Products

Co-Researchers

Development of small molecule Galectin-9 antagonists as a novel immune checkpoint inhibitorPrincipal Investigator

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Examination of the effect of combination therapy of galectin-9 and epigallocatechin gallate on hepatocellular carcinoma

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Functional elucidation of two forms of Galectin-9 and their potential application to diagnosisPrincipal Investigator

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Anti-tumor effect of Galectin-9 on metastatic hepatocellular carcinoma and its microRNA basis

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Matricellular proteins as severity markers for disaster or tropical infectious diseases

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A study on preparation of single receptor specific lectin and its usefulnessPrincipal Investigator

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A study on the clinical significance of matri-cellular proteins in tropical and disaster infections

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Th17-suppressing novel regulatory T cells and the use thereofPrincipal Investigator

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Clinical Utilities of new biomarker for dengue virus infection

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The alteration of sugar chain profiling during the differentiation into IL-17-producing helper T cells

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Possible mechanisms of galectin-9-induced immunoregulatory macrophages

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[Journal Article] Plasma N‐Cleaved Galectin‐9 Is a Surrogate Marker for Determining the Severity of COVID‐19 and Monitoring the Therapeutic Effects of Tocilizumab2023

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[Journal Article] Human galectin-9 potently enhances SARS-CoV-2 replication and inflammation in airway epithelial cells2023

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Niki Toshiro 仁木敏朗

NIKI Toshiro 仁木敏朗