Misawa Takashi 三澤隆史

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MISAWA Takashi 三澤隆史

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Researcher Number	40709820
Other IDs
Affiliation (Current)	2025: 国立医薬品食品衛生研究所, 有機化学部, 室長
Affiliation (based on the past Project Information) *help	2019 – 2023: 国立医薬品食品衛生研究所, 有機化学部, 室長 2017 – 2018: 国立医薬品食品衛生研究所, 有機化学部, 主任研究官 2016: 国立医薬品食品衛生研究所, 有機化学部, 任期付研究員 2013 – 2015: 国立医薬品食品衛生研究所, 有機化学部, 研究員 2013: 東京大学, 分子細胞生物学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Drug development chemistry Except Principal Investigator Drug development chemistry
Keywords	Principal Investigator ヘリカルテンプレート / ヘリカル構造 / ペプチド / クリックケミストリー / post-modification / 非天然アミノ酸 / ヘリカルペプチド / siRNA / ドラッグデリバリーシステム / 酵素耐性 … More / タンパク質間相互作用阻害剤 / ビタミンD受容体 / タンパク質間相互作用 / 構造活性相関 / 中分子創薬 / 生理活性ペプチド / 膜透過性ペプチド / 核酸デリバリー / 細胞膜透過性ペプチド / postmodification / a,a-ジ置換アミノ酸 / 膜透過ペプチド / 固相合成 / 抗菌活性 / 細胞膜透過性 / ジ置換アミノ酸 / ファーマコロジカルシャペロン / ABCD1 / 超長鎖脂肪酸 / 副腎白質ジストロフィー … More Except Principal Investigator 変異ロドプシン / 網膜色素変性症 / 酵素阻害剤 / ニーマン・ピック病Ｃ型 / 膜タンパク質 / 蛋白質相互作用 / 生理活性物質 / 核内受容体リガンド / マルチテンプレート / 蛋白変性症 / フォールディング異常症 / トラフィッキング Less

Functionalization of the helical template peptides for development of medium sized peptides drugs.Principal Investigator
- Principal Investigator
  
  三澤隆史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  National Institute of Health Sciences
Development of helical promoter sequence and its application for bioactive peptides.Principal Investigator
- Principal Investigator
  
  Misawa Takashi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  National Institute of Health Sciences
Development of cell penetrating peptides based on helical promoter for biomedical applicationPrincipal Investigator
- Principal Investigator
  
  Misawa Takashi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  National Institute of Health Sciences
Development of helical template peptides for post-functionalizationPrincipal Investigator
- Principal Investigator
  
  Misawa Takashi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences
Development of novel small molecules which rescue the trafficking of mutated ABCD1 responsible for adrenoleukodystrophyPrincipal Investigator
- Principal Investigator
  
  MISAWA Takashi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences
Chemical control of protein dramatype
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2012 2011 Other

All Journal Article Presentation

[Journal Article] In silico optimization of peptides that inhibit Wnt/β-catenin signaling2023
- Author(s)
  Fujita Minami、Tsuchiya Keisuke、Kurohara Takashi、Fukuhara Kiyoshi、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 84 Pages: 117264-117264
- DOI
  10.1016/j.bmc.2023.117264
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-22K06508, KAKENHI-PROJECT-20K06958
[Journal Article] Magainin 2-derived stapled peptides derived with the ability to deliver pDNA, mRNA, and siRNA into cells.2023
- Author(s)
  M. Hirano, H. Yokoo, C. Goto, M. Oba, T. Misawa, Y. Demizu
- Journal Title
  
  Chemical Science
  
  Volume: 14 Issue: 38 Pages: 10403-10410
- DOI
  10.1039/d3sc04124g
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KJ2570, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-23K06043, KAKENHI-WRAPUP-23H05424, KAKENHI-PLANNED-23H04926
[Journal Article] Enhancing Chemical Stability through Structural Modification of Antimicrobial Peptides with Non-Proteinogenic Amino Acids2023
- Author(s)
  Ito Takahito、Matsunaga Natsumi、Kurashima Megumi、Demizu Yosuke、Misawa Takashi
- Journal Title
  
  Antibiotics
  
  Volume: 12 Issue: 8 Pages: 1326-1326
- DOI
  10.3390/antibiotics12081326
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-23K06043
[Journal Article] Developmental Trends of Peptide Drugs and Their Quality Assessment using Secondary Structure Analysis2023
- Author(s)
  Misawa Takashi、Demizu Yosuke
- Journal Title
  
  ChemistrySelect
  
  Volume: 8 Issue: 11 Pages: 1-8
- DOI
  10.1002/slct.202300408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-20K06958
[Journal Article] Structure?Activity Relationship Study of Helix-Stabilized Antimicrobial Peptides Containing Nonproteinogenic Amino Acids2023
- Author(s)
  Ito Takahito、Hashimoto Wakana、Ohoka Nobumichi、Misawa Takashi、Inoue Takao、Kawano Ryuji、Demizu Yosuke
- Journal Title
  
  ACS Biomaterials Science & Engineering
  
  Volume: 9 Issue: 8 Pages: 4654-4661
- DOI
  10.1021/acsbiomaterials.3c00759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-20K06958, KAKENHI-PLANNED-23H04926
[Journal Article] Oligoarginine-Conjugated Peptide Foldamers Inhibiting Vitamin D Receptor-Mediated Transcription2022
- Author(s)
  Takyo Mami、Sato Yumi、Hirata Naoya、Tsuchiya Keisuke、Ishida Hiroaki、Kurohara Takashi、Yanase Yuta、Ito Takahito、Kanda Yasunari、Yamamoto Keiko、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  ACS Omega
  
  Volume: 7 Issue: 50 Pages: 46573-46582
- DOI
  10.1021/acsomega.2c05409
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06958, KAKENHI-PROJECT-21K05320, KAKENHI-PLANNED-18H05502
[Journal Article] Structure?Activity Relationship Studies of Substitutions of Cationic Amino Acid Residues on Antimicrobial Peptides2022
- Author(s)
  Takada Mayu、Ito Takahito、Kurashima Megumi、Matsunaga Natsumi、Demizu Yosuke、Misawa Takashi
- Journal Title
  
  Antibiotics
  
  Volume: 12 Issue: 1 Pages: 19-19
- DOI
  10.3390/antibiotics12010019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-20K06958
[Journal Article] Helical Foldamers and Stapled Peptides as New Modalities in Drug Discovery: Modulators of Protein-Protein Interactions2022
- Author(s)
  Tsuchiya Keisuke、Kurohara Takashi、Fukuhara Kiyoshi、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  Processes
  
  Volume: 10 Issue: 5 Pages: 924-924
- DOI
  10.3390/pr10050924
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06958, KAKENHI-PROJECT-21K05320, KAKENHI-PLANNED-18H05502
[Journal Article] Development of a penetratin-conjugated stapled peptide that inhibits Wnt/β-catenin signaling2022
- Author(s)
  Tsuchiya Keisuke、Kiyoshi Masato、Hashii Noritaka、Fujita Minami、Kurohara Takashi、Ishii-Watabe Akiko、Fukuhara Kiyoshi、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 73 Pages: 117021-117021
- DOI
  10.1016/j.bmc.2022.117021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06958, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-22K06508, KAKENHI-PLANNED-18H05502
[Journal Article] Helical Antimicrobial Peptide Foldamers Containing Non‐proteinogenic Amino Acids2021
- Author(s)
  Yokoo Hidetomo、Hirano Motoharu、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  ChemMedChem
  
  Volume: 16 Issue: 8 Pages: 1226-1233
- DOI
  10.1002/cmdc.202000940
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18K14880, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320
[Journal Article] Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence2021
- Author(s)
  Hirano Motoharu、Saito Chihiro、Yokoo Hidetomo、Goto Chihiro、Kawano Ryuji、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  Molecules
  
  Volume: 26 Issue: 2 Pages: 444-444
- DOI
  10.3390/molecules26020444
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18K14880, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320
[Journal Article] Rational Design of Helix‐Stabilized Antimicrobial Peptide Foldamers Containing α,α‐Disubstituted Amino Acids or Side‐Chain Stapling2020
- Author(s)
  Hirano Motoharu、Saito Chihiro、Goto Chihiro、Yokoo Hidetomo、Kawano Ryuji、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  ChemPlusChem
  
  Volume: 85 Issue: 12 Pages: 2731-2736
- DOI
  10.1002/cplu.202000749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-20K22711, KAKENHI-PROJECT-18K14880
[Journal Article] De Novo Design of Cell‐Penetrating Foldamers2020
- Author(s)
  Yokoo Hidetomo、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  The Chemical Record
  
  Volume: 20 Issue: 9 Pages: 912-921
- DOI
  10.1002/tcr.202000047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18K14880
[Journal Article] Development of Selective TGR5 Ligands Based on the 5,6,7,8‐Tetrahydro‐5,5,8,8‐tetramethylnaphthalene Skeleton2020
- Author(s)
  Terui Ryusei、Yanase Yuta、Yokoo Hidetomo、Suhara Yoshitomo、Makishima Makoto、Demizu Yosuke、Misawa Takashi
- Journal Title
  
  ChemMedChem
  
  Volume: 16 Issue: 3 Pages: 458-462
- DOI
  10.1002/cmdc.202000567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22711, KAKENHI-PROJECT-18K14880, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320
[Journal Article] Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating peptide foldamers for efficient siRNA delivery2019
- Author(s)
  T. Misawa,* N. Ohoka,* M. Oba, H. Yamashita, M. Tanaka, M. Naito, Y. Demizu*
- Journal Title
  
  Chem. Commun.
  
  Volume: 55 Issue: 54 Pages: 7792-7795
- DOI
  10.1039/c9cc02203a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K14880, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502
[Journal Article] The extent of helical induction caused by introducing a-aminoisobutyric acid into an oligovaline sequence2018
- Author(s)
  G. Tsuji, T. Misawa, M. Doi, Y. Demizu*
- Journal Title
  
  ACS Omega
  
  Volume: 3 Issue: 6 Pages: 6395-6399
- DOI
  10.1021/acsomega.8b01030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K14880
[Journal Article] Structural Development of Cell-Penetrating Peptides Containing Cationic Proline Derivatives2018
- Author(s)
  H. Kobayashi, T. Misawa,* M. Oba, N. Hirata, Y. Kanda, M. Tanaka, K. Matsuno, Y. Demizu*
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 66 Issue: 5 Pages: 575-580
- DOI
  10.1248/cpb.c18-00079
- NAID
  130006729546
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2018-05-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K14880, KAKENHI-PROJECT-17H04107, KAKENHI-PROJECT-17K19503
[Journal Article] Development of helix-stabilized antimicrobial peptides composed of lysine and hydrophobic alpha,alpha-disubstituted alpha-amino acid residues2017
- Author(s)
  T. Misawa, M. Imamura, Y. Ozawa, K. Haishima, M. Kurihara, Y. Kikuchi,* Y. Demizu*
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 27 Issue: 17 Pages: 3950-3953
- DOI
  10.1016/j.bmcl.2017.07.074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-15K18905, KAKENHI-PROJECT-26460169
[Journal Article] Rational design and synthesis of post-functionalizable peptide foldamers as helical templates2017
- Author(s)
  T. Misawa,* Y. Kanda, Y. Demizu*
- Journal Title
  
  Bioconj. Chem.
  
  Volume: 28 Issue: 12 Pages: 3029-3035
- DOI
  10.1021/acs.bioconjchem.7b00621
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-17K19503, KAKENHI-PROJECT-15K18905, KAKENHI-PROJECT-17H04107, KAKENHI-PROJECT-26460169
[Journal Article] Efficient synthesis of a multi-substituted diphenylmethane skeleton as a steroid mimetic2017
- Author(s)
  takashi misawa, katsuya tanaka, yosuke demizu, masaaki kurihara
- Journal Title
  
  bioorganic medicinal chemistry letter
  
  Volume: 印刷中 Issue: 11 Pages: 2590-2593
- DOI
  10.1016/j.bmcl.2017.03.066
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18905, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-26460169
[Journal Article] A Helix-Stabilized Cell-Penetrating Peptide As An Intracellular-Delivery Tool2016
- Author(s)
  Hiroko Yamashita, Makoto Oba, Takashi Misawa, Masakazu Tanaka, Takayuki Hattori, Mikihiko Naito, Masaaki Kurihara, Yosuke Demizu
- Journal Title
  
  Chembiochem
  
  Volume: 17 Issue: 2 Pages: 137-140
- DOI
  10.1002/cbic.201500468
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08040, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-15K18905
[Journal Article] Structure-Activity Relationships of Benzhydrol Derivatives Based on 1'-Acetoxychavicol Acetate (ACA) and their Inhibitory Activities on Multiple Myeloma Cell Growth via Inactivation of the NF-kB Pathway2015
- Author(s)
  Takashi Misawa, Kosuke Dodo, Minoru Ishikawa, Yuichi Hashimoto, Morihiko Sagawa, Masahiro Kizaki, Hiroshi Aoyama
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 23 Issue: 9 Pages: 2241-2246
- DOI
  10.1016/j.bmc.2015.02.039
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670053, KAKENHI-PROJECT-25893038, KAKENHI-PROJECT-15K09490, KAKENHI-PROJECT-15K18905, KAKENHI-PROJECT-25293027
[Journal Article] Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton2015
- Author(s)
  Takashi Misawa, Momoko Yorioka, Yosuke Demizu, Tomomi Noguchi-Yachide, Nobumichi Ohoka, Megumi Kurashima-Kinoshita, Hitomi Motoyoshi, Hisao Nojiri, Atsushi Kittaka, Makoto Makishima, Mikihiko Naito, Masaaki Kurihara
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 25 Issue: 22 Pages: 5362-5366
- DOI
  10.1016/j.bmcl.2015.09.030
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-15K18905, KAKENHI-PROJECT-26860049
[Journal Article] Topological study of the structures of heterochiral peptides with equal amounts of L-Leu and D-Leu2015
- Author(s)
  Y. Demizu,* H. Yamashita, M. Doi, T. Misawa, M. Oba, M. Tanaka, M. Kurihara*
- Journal Title
  
  J. Org. Chem.
  
  Volume: 80 Issue: 17 Pages: 8597-8603
- DOI
  10.1021/acs.joc.5b01541
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-15K18905
[Journal Article] Structural development of stapled short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors.2015
- Author(s)
  T. Misawa, Y. Demizu, M. Kawamura, N. Yamagata, M. Kurihara.
- Journal Title
  
  Bioorganic medicinal chemistry
  
  Volume: 23 Issue: 5 Pages: 1055-1061
- DOI
  10.1016/j.bmc.2015.01.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25893038, KAKENHI-PROJECT-26460169
[Journal Article] Structure-activity relationship-guided development of retinoic acid receptor-related orphan receptor gamma (RORγ)-selective inverse agonists with a phenanthridin- 6(5H)-one skeleton from a liver X receptor ligand2014
- Author(s)
  Y.Nishiyama, M.Nakamura, T.Misawa, M.Nakagomi, M.Makishima, M.Ishikawa, Y.Hashimoto
- Journal Title
  
  Boorg. Med. Chem.
  
  Volume: 22 Issue: 9 Pages: 2799-2808
- DOI
  10.1016/j.bmc.2014.03.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-25670053
[Journal Article] E297G Mutated bile salt export pump (BSEP) function enhancers derived from GW4064: Structural development study and separation from farnesoid X receptor-agonistic activity.2012
- Author(s)
  Takashi Misawa　他４名
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 22 Issue: 12 Pages: 3962-3996
- DOI
  10.1016/j.bmcl.2012.04.099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-23790175
[Journal Article] Discovery and structural development of small molecules that enhance transport activity of bile salt export pump mutant associated with progressive familial intrahepatic cholestasis type 22012
- Author(s)
  Misawa T.
- Journal Title
  
  Bioorganic Medicinal Chemistry
  
  Volume: 20 Issue: 9 Pages: 2940-2949
- DOI
  10.1016/j.bmc.2012.03.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J10912, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-23790175
[Journal Article] Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist2012
- Author(s)
  Y. Itoh, M. Ishikawa, R.Kitaguchi, K.Okuhira, M.Naito, Y.Hashimoto
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 22 Issue: 13 Pages: 4453-4457
- DOI
  10.1016/j.bmcl.2012.04.134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-22790102, KAKENHI-PROJECT-23659048, KAKENHI-PROJECT-23790125
[Presentation] 生理活性ペプチドの効率的導出に向けたヘリカルテンプレートの開発2023
- Author(s)
  三澤隆史 1 、加藤巧馬2、伊藤貴仁1, 3 、大岡伸通 1、井上貴雄1、土井光暢2 、出水庸介
- Organizer
  ケミカルバイオロジー学会
- Data Source
  KAKENHI-PROJECT-23K06043
[Presentation] カチオン性ジ置換アミノ酸を導入した抗菌ペプチドフォルダマーの開発2023
- Author(s)
  三澤　隆史1、伊藤　貴仁1,2、倉島　恵愛1、出水　庸介
- Organizer
  日本薬学会第144回年会
- Data Source
  KAKENHI-PROJECT-23K06043
[Presentation] Development of helical template peptides for efficient DDS carrier2023
- Author(s)
  三澤隆史，伊藤貴仁，加藤巧馬，大岡伸通，井上貴雄，土井光暢，出水庸介
- Organizer
  第60回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-20K06958
[Presentation] ヘリカルテンプレートペプチドの開発とDDSキャリアへの応用2023
- Author(s)
  三澤　隆史
- Organizer
  日本薬学会第144回年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K06043
[Presentation] GalNAc-conjugated helical peptides as tissue-selective carrier2023
- Author(s)
  伊藤貴仁，三澤隆史，出水庸介
- Organizer
  第60回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-20K06958
[Presentation] Wnt/β-cateninシグナル経路阻害ペプチドのin silico設計2023
- Author(s)
  藤田陽，三澤隆史，出水庸介
- Organizer
  第67回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-20K06958
[Presentation] Design of hydrophobic cell-penetrating stapled peptides as drug carriers2023
- Author(s)
  平野元春，横尾英知，大庭誠，三澤隆史，出水庸介
- Organizer
  第60回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-20K06958
[Presentation] Structural development of helix-stabilized Block peptides for intracellular delivery of siRNA2022
- Author(s)
  三澤隆史、大岡伸通、平野元春、大庭誠、井上貴雄、出水庸介
- Organizer
  第59回日本ペプチド学会
- Data Source
  KAKENHI-PROJECT-20K06958
[Presentation] 生理活性ペプチドの効率的導出に向けたヘリカルテンプレートの開発2022
- Author(s)
  三澤隆史、加藤巧馬、伊藤貴仁、大岡伸通、井上貴雄、土井光暢、出水庸介
- Organizer
  日本ケミカルバイオロジー学会第16回年会
- Data Source
  KAKENHI-PROJECT-20K06958
[Presentation] Fundamental Studies on the Development of Next-Generation medium sized peptide drugs2022
- Author(s)
  三澤　隆史
- Organizer
  Korean protein peptide symposium 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06958
[Presentation] ビタミンD受容体の転写機能を調節する新規ペプチドフォルダマーの開発2022
- Author(s)
  三澤隆史
- Organizer
  日本ビタミン学会第74回大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K06958
[Presentation] Fundamental Studies on the Development of Next-Generation Medium Sized Peptide Drugs2021
- Author(s)
  三澤隆史
- Organizer
  第58回ペプチド討論会
- Invited
- Data Source
  KAKENHI-PROJECT-20K06958
[Presentation] 次世代中分子ペプチド医薬品創出に向けた基盤技術の開発2021
- Author(s)
  三澤　隆史
- Organizer
  第65回日本薬学会関東支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K06958
[Presentation] Development of post-functionalizable antimicrobial peptide foldamers.2020
- Author(s)
  三澤隆史、平野元春、横尾英知、出水庸介
- Organizer
  第57回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-18K14880
[Presentation] 新規TGR5リガンドの開発2020
- Author(s)
  三澤隆史、照井龍晟、槇島誠、須原義智、出水庸介
- Organizer
  日本ビタミン学会第72回大会
- Data Source
  KAKENHI-PROJECT-18K14880
[Presentation] 5,6,7,8-Tetrahydronaphthalene骨格を用いた選択的TGR5アゴニストの開発2020
- Author(s)
  三澤隆史、照井龍晟、栁瀨雄太、横尾英知、槇島誠、須原義智、出水庸介
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-18K14880
[Presentation] ヘリカルテンプレートペプチドの合成とpost-modificationによる機能化2019
- Author(s)
  三澤隆史、出水庸介
- Organizer
  日本薬学会第139会年会
- Data Source
  KAKENHI-PROJECT-15K18905
[Presentation] 多様な機能を付与できる細胞膜高透過性ペプチドの開発2019
- Author(s)
  三澤隆史、大岡伸通、大庭誠、田中正一、内藤幹彦、出水庸介
- Organizer
  日本ケミカルバイオロジー学会第15回年会
- Data Source
  KAKENHI-PROJECT-18K14880
[Presentation] DEVELOPMENT OF CELL-PENETRATING FOLDAMERS FOR DELIVERY OF BIOMACROMOLECULES2019
- Author(s)
  三澤隆史、大岡伸通、大庭誠、田中正一、内藤幹彦、出水庸介
- Organizer
  第56回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-18K14880
[Presentation] Development of Cell-Penetrating Peptide Foldamers for siRNA Delivery2018
- Author(s)
  Takashi Misawa, Nobumichi Ohoka, Makoto Oba, Masakazu Tanaka, Mikihiko Naito, Yosuke Demizu
- Organizer
  第10会ペプチドシンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14880
[Presentation] 多様な官能基修飾を志向したヘリカルテンプレートペプチドの開発2018
- Author(s)
  三澤隆史、諫田泰成、出水庸介
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-15K18905
[Presentation] 二次構造制御を基盤とした膜透過性ペプチドの開発と核酸デリバリーへの応用2018
- Author(s)
  三澤隆史、大岡伸通、大庭誠、田中正一、内藤幹彦、出水庸介
- Organizer
  第34会日本DDS学会
- Data Source
  KAKENHI-PROJECT-18K14880
[Presentation] 細胞膜高透過性ペプチドフォルダマーの開発と核酸デリバリーへの応用2018
- Author(s)
  三澤隆史、大岡伸通、大庭誠、田中正一、内藤幹彦、出水庸介
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-18K14880
[Presentation] Development of helix-stabilized amphipathic cell-penetrating peptides for siRNA delivery2018
- Author(s)
  Takashi Misawa, Nobumichi Ohoka, Makoto Oba, Masakazu Tanaka, Mikihiko Naito, Yosuke Demizu
- Organizer
  第35会ヨーロッパペプチドシンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14880
[Presentation] 核酸医薬を細胞内に導入するオリゴペプチドの開発2018
- Author(s)
  三澤隆史、大岡伸通、大庭誠、田中正一、内藤幹彦、出水庸介
- Organizer
  日本ケミカルバイオロジー学会第11回年会
- Data Source
  KAKENHI-PROJECT-18K14880
[Presentation] 多様な生理活性付与を志向した安定化ヘリカルテンプレートペプチドの開発2017
- Author(s)
  三澤隆史、出水庸介
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-15K18905
[Presentation] Development of post functionalizable foldamers as helical template2017
- Author(s)
  三澤隆史、出水庸介
- Organizer
  第54回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-15K18905
[Presentation] 親水性分子の細胞内導入を志向した高膜透過性ペプチド2017
- Author(s)
  三澤　隆史
- Organizer
  日本薬学会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K18905
[Presentation] ヘリカルプロモーター導入によるオリゴアルギニンの構造制御と膜透過能への効果2016
- Author(s)
  三澤隆史、山下博子、加藤巧馬、服部隆行、大庭誠、田中正一、内藤幹彦、出水庸介、栗原正明
- Organizer
  日本薬学会第136年会
- Place of Presentation
  神奈川
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K18905
[Presentation] ノンセコステロイド型VDRリガンドの創製2015
- Author(s)
  三澤隆史、出水庸介、槇島誠、栗原正明
- Organizer
  第一回　Neo VDR workshop
- Place of Presentation
  滋賀
- Year and Date
  2015-08-28
- Invited
- Data Source
  KAKENHI-PROJECT-15K18905
[Presentation] 長鎖アルキル基を有するノンセコステロイド型VDRリガンドの創製2015
- Author(s)
  三澤隆史，依岡桃子，出水庸介，大岡伸通，木下恵愛，槇島誠，内藤幹彦，栗原正明
- Organizer
  第41回反応と合成の進歩シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2015-10-25
- Data Source
  KAKENHI-PROJECT-15K18905
[Presentation] Structure-activity relationship analysis of short helical peptides as VDR-coactivator interaction inhibitors.2015
- Author(s)
  Takashi Misawa, Yosuke Demizu, Masaaki Kurihara
- Organizer
  第43回構造活性相関シンポジウム
- Place of Presentation
  新潟
- Year and Date
  2015-09-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18905
[Presentation] 長鎖アルキル基を有するビタミンD受容体の創製2015
- Author(s)
  三澤　隆史、依岡　桃子、出水　庸介、大岡　伸通、木下　恵愛、槇島　誠、内藤　幹彦、栗原正明
- Organizer
  第59回日本薬学会関東支部大会
- Place of Presentation
  千葉
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K18905
[Presentation] ノンセコステロイド型ビタミンD受容体リガンドの創製〜官能基変換による活性制御〜2015
- Author(s)
  三澤　隆史、依岡　桃子、出水　庸介、大岡　伸通、木下　恵愛、槇島　誠、内藤　幹彦、栗原正明
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  千葉
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-15K18905
[Presentation] Design and Synthesis of Short Helical Peptides as Vitamin D Receptor (VDR)-Coactivator Interaction Inhibitors2015
- Author(s)
  Takashi Misawa, Yosuke Demizu, Masaaki Kurihara
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  神奈川
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-15K18905
[Presentation] ヘリカルペプチドを用いたビタミンD受容体(VDR)—コアクチベータ相互作用阻害剤の創製2015
- Author(s)
  ○三澤隆史、出水庸介、栗原正明
- Organizer
  日本ケミカルバイオロジー学会第10回年会
- Place of Presentation
  仙台
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-15K18905
[Presentation] Design and synthesis of short helical peptides as vitamin receptor –coactivator interaction inhibitors2015
- Author(s)
  Takashi Misawa, Yosuke Demizu, Masaaki Kurihara
- Organizer
  2015環太平洋国際科学会議
- Place of Presentation
  米国
- Year and Date
  2015-12-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18905
[Presentation] マルチテンプレート手法を用いた新規TGR5 リガンドの創製研究2014
- Author(s)
  小針孝夫、三澤隆史、橋本祐一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] PFIC2 の原因となる変位型BSEP の機能を修正する新規小分子の発見と構造展開2012
- Author(s)
  三澤隆史、林久允、杉山雄一、橋本祐一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] PFIC2の原因となる変位型BSEPの機能を修正する新規小分子の発見と構造展開2012
- Author(s)
  三澤隆史, 他4名
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] Structural development study of a novel pharmacological chaperon for folding-defective bile salts export pump mutants responsible for PFIC22011
- Author(s)
  Takashi Misawa, 他3名
- Organizer
  8^<th> AFMC International Medicinal Chemistry Symposium "Frontier of Medicinal Science"
- Place of Presentation
  東京
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] カンナビノイド調整薬の設計と合成
- Author(s)
  三澤隆史、出水庸介、船田正彦、栗原正明
- Organizer
  日本薬学会第135回年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25893038

1. HASHIMOTO Yuichi (90164798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. ISHIKAWA Minoru (70526839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. AOYAMA Hiroshi (40374699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SUGITA Kazuyuki (60542090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KOBAYASHI Hisayoshi (80225531)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YACHIDE Tomomi (20401284)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MATSUMOTO Yotaro (90420041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KITTAKA Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 出水庸介

# of Collaborated Projects: 0 results

# of Collaborated Products: 12 results
10. 伊藤拓水

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 横尾英知

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
12. 服部隆行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Misawa Takashi 三澤 隆史

MISAWA Takashi 三澤 隆史

Research Projects

Research Products

Co-Researchers

Functionalization of the helical template peptides for development of medium sized peptides drugs.Principal Investigator

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Development of helical promoter sequence and its application for bioactive peptides.Principal Investigator

Principal Investigator

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Development of cell penetrating peptides based on helical promoter for biomedical applicationPrincipal Investigator

Principal Investigator

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Development of helical template peptides for post-functionalizationPrincipal Investigator

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Development of novel small molecules which rescue the trafficking of mutated ABCD1 responsible for adrenoleukodystrophyPrincipal Investigator

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Chemical control of protein dramatype

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[Journal Article] In silico optimization of peptides that inhibit Wnt/β-catenin signaling2023

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[Journal Article] Magainin 2-derived stapled peptides derived with the ability to deliver pDNA, mRNA, and siRNA into cells.2023

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[Journal Article] Enhancing Chemical Stability through Structural Modification of Antimicrobial Peptides with Non-Proteinogenic Amino Acids2023

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[Journal Article] Developmental Trends of Peptide Drugs and Their Quality Assessment using Secondary Structure Analysis2023

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[Journal Article] Structure?Activity Relationship Study of Helix-Stabilized Antimicrobial Peptides Containing Nonproteinogenic Amino Acids2023

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[Journal Article] Oligoarginine-Conjugated Peptide Foldamers Inhibiting Vitamin D Receptor-Mediated Transcription2022

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[Journal Article] Structure?Activity Relationship Studies of Substitutions of Cationic Amino Acid Residues on Antimicrobial Peptides2022

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[Journal Article] Helical Foldamers and Stapled Peptides as New Modalities in Drug Discovery: Modulators of Protein-Protein Interactions2022

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DOI

Misawa Takashi 三澤隆史

MISAWA Takashi 三澤隆史