HAYAKAWA Yoshihiro 早川芳宏

… Alternative Names

早川芳宏ハヤカワヨシヒロ

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Researcher Number	50022702
Other IDs
External Links
Affiliation (Current)	2025: 愛知工業大学, 工学部, 教授
Affiliation (based on the past Project Information) *help	2009 – 2015: Aichi Institute of Technology, 工学部, 教授 2008: Nagoya University, 大学院・情報科学研究科, 教授 2006: Nagoya University, Graduate School of Information Science, Professor, 大学院情報科学研究科, 教授 2004 – 2005: 名古屋大学, 大学院・情報科学研究科, 教授 1996 – 2001: 名古屋大学, 大学院・人間情報学研究科, 教授 … More 1999: 名大, 人間情報学研究科, 教授 1993 – 1994: 名古屋大学, 人間情報学研究科, 教授 1992: 名古屋大学, 大学院・人間情報, 教授 1992: 名古屋大学, 大学院人間情報学研究科, 教授 1991: 名古屋大学, 教養部, 教授 1990 – 1991: 名古屋大学, 教養部, 助教授 1990: 名古屋大, 教養学部, 助教授 1987 – 1989: 名古屋大学, 化学測定機器センター, 助教授 Less
Review Section/Research Field	Principal Investigator Chemistry related to living body / 物質変換 / Chemistry / Organic chemistry / Biological Sciences / Bioorganic chemistry
Keywords	Principal Investigator アンチセンス核酸 / c-di-GMP / ホスホロアミダイト法 / バイオフィルム / DNA合成 / CMP-Neu5Ac / antisense nucleic acid / acid / phosphoramidite method / アミダイト法 … More / 酸 / 抗がん剤 / 免疫活性化剤 / 抗がん作用 / バイオフィルム感染症 / STING / ワクチン / 免疫 / 黄色ブドウ球菌 / biofilm / ヌクレオチド / 光学活性アゾール / 不斉合成 / 動的速度分割 / DNAオリゴマー / 2-5A / キャップ構造 / biofilm-forming bacterial infection / Pseudomonas aeruginosa / Staphylococcus aureus / immune enhancer / oligonucleotide / 促進剤 / カルボン酸 / 鉄還元菌 / ユニバーサル塩基 / 免疫応答活性化 / バイオフィルム感染症治療薬 / 緑膿菌 / 免疫刺激剤 / オリグヌクレオチド / N-acylated DNA / H-phosphonate method / telomere / oxanosine / azole complex / allyl protection / 塩基配列認識ペプチド / 一酸化窒素による発ガン / DNA-ペプチドコンジュゲート / アリル保護アミダイト法 / 修飾DNAオリゴマー / 塩基部無保護アミダイト法 / 分子認識能 / 塩基対形成能 / N-アシルDNA / クロスリンク / 遺伝子傷害 / RNAオリゴマー / 一酸化窒素 / デオキシオキザノシン / CMP-New5Ac / ヌクレオチド化学合成 / N-アシル化DNA / H-ホスホネート法 / テロメア / オキザノシン / アゾール複合体 / アリル保護法 / base complex-type promoter / DNA synthesis / dynamic kinetic resolution / optically active tetrazoles / optically active imidazole / asymmetric synthesis / ホスホロアミダイト / 塩基複合活性化剤 / ヌクレオチドホスホロチオエ-ト / 光学活性リン酸エステル / 酸・塩基複合促進剤 / 塩基部無保護DNA合成法 / 酸塩基複合促進剤 / 光学活性テトラゾール / 光学活性イミダゾール / 生理活性 / Riboswitch / 癌 / 核酸 / c[G(2'-5')pA(3'-5')p] / c[G(3'-5')pA(3'-5')p] / がん免疫療法 / ガン免疫療法 / がん / がん細胞増殖抑制 / 免疫活性 / 2',3'-cGAMP / 環状ジヌクレオチド / ヒト骨髄性白血病細胞 / ヒトアナプラスマ症 / 2'-O-TBDMS-c-di-GMP / 肺炎球菌 / 感染症治療薬 / 環状ジグアリル酸 / メチシリン耐性黄色ブドウ球菌 / アジュバント / 免疫賦活剤 / 細菌感染症 / 環状ビス(3' -5')ジグアニル酸 / 機能性タンパク質 / インターフェロン / 免疫活性化 / 環状ジグアニル酸 / 薬剤耐性菌 / 環状ビス(3'-5')ジグアニル酸 / 核酸・蛋白質・糖化学 / RNA / トリフルオロメタンスルホン酸イミダゾリウム / DNA合成法 / アリル保護基 / ホスホロアミダイド法 / DNA-ペプチド複合体 / DNA-アミノ酸複合体 / DNAホスホロチオエート / 光学活性リン化合物 / 酸・塩基複合型促進剤 / 光学活性アミン / DNAホスホロチオエ-ト / リン酸修飾型オリゴDNA / DNAフェニルホスホネート / パラジウム触媒反応 / オリゴDNA / アンチセンス法 / エイズ / オリゴチオアデニル酸 / ヌクレオチドリンポルフィリン誘導体 / オリゴヌクレオチド / リン酸トリエステル修飾DNA / 人工制限酵素 / 5'-ポリリン酸ヌクレオチド / 人工光制限酵素 / オリゴヌクレオチドP(V)ポリフィリン誘導体 / 2'-O-D-リボフラノシルアデノシン / CMP-シアル酸 / ピロリン酸結合 / 修飾塩基 / アセチルセルロ-ス担体 / オリゴヌクレオチドりんポルフィリン誘導体 / グアノシンのメチル化 / 2ー5A / 水酸基活性化法 … More Except Principal Investigator 構造 / 核酸 / BINAP / 遺伝子 / 分子設計 / 有機化学 / 機能 / RNA / DNA / Pd(0)Catalyzed deprotection / CAB / MAD / BINAP-Ru / BINAP-Rh / TMSOTf / BINAL-H / プロスタグランジン / ビタミン / シトロネロール / ナブロキャン / 1-βメチルチエナマイシン / ルテニウム錯体 / イソカルバサイクリン / パラジウム / アリルオキシカルボニル / アントラサイクリン / 2-5A / O価バラジウム / 不斉触媒 / 不斉増幅 / 有機アルミニウム / 不斉アルキル化 / DNA固相合成 / プロスタグランジン合成 / BINAP錯体 / 不斉DielsーAlder反応 / アシロキシボラン / 有機亜鉛化合物 / アミノアルコール / 分子内エン反応 / 超原子価スズ化合物 / 超純度DNA合成 / アリル系保護基 / 不斉クライゼン転位 / アルキル化 / 有機亜鉛 / DAIB / 不斉水素化 / 新脱保護法 / パラジウム(0)錯体触媒 / 高選択的1,4ー付加反応 / 有機,鉛化合物 / 新有機化学反応 / 機能性核酸 / アンチセンス核酸 / NMR / 核酸有機化学 / 核酸構造 / オリゴヌクレオチド / リボザイム Less

Investigation on biological activity of cyclic dinucleotides and elucidation of mechanism how the activity is expressed, directing toward invention of new immunostimulantsPrincipal Investigator
- Principal Investigator
  
  Hayakawa Yoshihiro
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Aichi Institute of Technology
Toward development of novel medicines for bacterial infection : Search of biological functions and elucidation of mechanism on occurrence of the functions of c-di-GMP and related compoundsPrincipal Investigator
- Principal Investigator
  
  HAYAKAWA Yoshihiro
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Aichi Institute of Technology
  Nagoya University
RNA関連ゲノム研究の礎となるRNAオリゴマーの高効率合成法の開発Principal Investigator
- Principal Investigator
  
  早川芳宏
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Creation and efficient synthesis of nucleic acids and related compounds with valuable functionality and bioactivityPrincipal Investigator
- Principal Investigator
  
  HAYAKAWA Yoshihiro
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Nagoya University
Basic Research for the Creation of Artificial Nucleic Acids and Related Biomolecules with Useful FunctionsPrincipal Investigator
- Principal Investigator
  
  HAYAKAWA Yoshihiro
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Chemistry
- Research Institution
  Nagoya University
生体関連有機リン化合物の高効率合成Principal Investigator
- Principal Investigator
  
  早川芳宏
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nagoya University
有機リン酸関連化合物の経済的、実用的合成法Principal Investigator
- Principal Investigator
  
  早川芳宏
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  物質変換
- Research Institution
  Nagoya University
制限酵素機能を有する人工修飾オリゴDNAの創出Principal Investigator
- Principal Investigator
  
  早川芳宏
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
動的速度分割による光学活性分子構築法:有機リン化合物の実用的不斉合成法の開発Principal Investigator
- Principal Investigator
  
  早川芳宏
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  物質変換
- Research Institution
  Nagoya University
Enantioselective Synthesis of Unsymmetrically-Substituted Organophosphorus Compounds with Stereogenic Phosphorus AtomsPrincipal Investigator
- Principal Investigator
  
  HAYAKAWA Yoshihiro
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Organic chemistry
- Research Institution
  Nagoya University
特異な構造をもつRNAの化学合成と反応Principal Investigator
- Principal Investigator
  
  早川芳宏
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
非イオン性インターヌクレオチド結合をもつDNAの合成と機能Principal Investigator
- Principal Investigator
  
  早川芳宏
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Nagoya University
核酸の構造と機能の有機化学的展開(成果とりまとめ)
- Principal Investigator
  
  畑辻明
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
核酸の構造と機能の有機化学的展開
- Principal Investigator
  
  畑辻明
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
特異な構造をもつRNAの化学合成と反応Principal Investigator
- Principal Investigator
  
  早川芳宏
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
核酸の構造と機能の有機化学的展開
- Principal Investigator
  
  畑辻明
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Institution
  Tokyo Institute of Technology
Development of New Organic Reactions and Synthesis of Physiologically Active Substance
- Principal Investigator
  
  NOYORI Ryoji
- Project Period (FY)
  1987 – 1990
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Research Institution
  Nagoya University

[Book] Chemical Properties and Biological Activities of Cyclic Bis(3'-5') diguanylic Acid(c-di-GMP) and Its Analogues. In Modified Nucleosides in Biochemistry, Biotechnology and Medicine2008
- Author(s)
  Mamoru Hyodo and Yoshihiro Hayakawa
- Data Source
  KAKENHI-PROJECT-20350076
[Book] Modified Nucleosides in Biochemistry, Biotechnology and Medicine(Chemical Properties and Biological Activities of Cyclic Bis(3'-5')diguanylic Acid (c-di-GMP) and Its Analogues.)(P.Herdewijn, Ed.)2008
- Author(s)
  M.Hyodo, Y.Hayakawa, Synthesis
- Publisher
  Wiley-VCH, Weinheim
- Data Source
  KAKENHI-PROJECT-20350076
[Book] Strategies Useful for the Chemical Synthesis of Oligonucleotides and Related Compounds "Frontiers in Organic Chemistry, Vol.1"2005
- Author(s)
  M.Tsukamoto, Y.Hayakawa(分担執筆)
- Publisher
  Bentham
- Data Source
  KAKENHI-PROJECT-16350086
[Book] Benzimidazolium Trifluoromethanesulfonate. In "Handbook of Reagents for Organic Synthesis : Reagents for Glycoside, Nucleotide, and Peptide Synthesis"(D. Crich, Ed.)2005
- Author(s)
  Y.Hayakawa
- Total Pages
  4
- Publisher
  John Wiley ＆ Sons
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Book] Ally Tetraisoproylphosphorodiamidite. In "Handbook of Reagents for Organic Synthesis : Reagents for Glycoside, Nucleotide, and Peptide Synthesis"(D. Crick. Ed.)2005
- Author(s)
  Y.Hayakawa, R.Kawai
- Total Pages
  7
- Publisher
  John Wiley ＆ Sons
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Book] Nucleobase Protection with Allyloxycarbonyl. In "Current Protocols in Nucleic Acid Chemistry"2005
- Author(s)
  M.Hyodo, Y.Hayakawa
- Total Pages
  26
- Publisher
  John Wiley ＆ Sons
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Book] Nucleobase Protection with Allyloxycarbonyl "Current Protocols in Nucleic Acid Chemistry, Supplement 23"2005
- Author(s)
  M.Hyodo, Y.Hayakawa
- Publisher
  John Wiley and Sons, Inc.
- Data Source
  KAKENHI-PROJECT-16350086
[Book] Strategies Useful for the Chemical Synthesis of Oligonucleotides and Related Compounds. In "Frontiers in Organic Chemistry"(Atta-Ur-Rahman and Y, Hayakawa, Ed)2005
- Author(s)
  M.Tsukamoto, Y.Hayakawa
- Total Pages
  38
- Publisher
  Bentham
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Book] Frontiers in Organic Chemistry, Volume 12005
- Author(s)
  Atta-ur-Rahman, Y.Hayakawa 編集
- Total Pages
  355
- Publisher
  Bentham
- Data Source
  KAKENHI-PROJECT-16350086
[Book] Frontiers in Organic Chemistry, Vol.12005
- Author(s)
  Atta-Ur-Rahman, Y. Hayakawa, Ed.
- Publisher
  Bentham
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Book] ヌクレオシド、ヌクレオチドおよび核酸類.「化学便覧基礎編改訂第5版-第I巻」2004
- Author(s)
  早川芳宏
- Total Pages
  10
- Publisher
  丸善
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Book] Frontiers in Organic Chemistry
- Author(s)
  Y.Hayakawa(editor)
- Publisher
  Bentham(印刷中)
- Data Source
  KAKENHI-PROJECT-16350086
[Book] Frontiers in Organic Chemistry
- Author(s)
  Y.Hayakawa (editor)
- Publisher
  Bentham(印刷中)
- Data Source
  KAKENHI-PROJECT-16011223
[Journal Article] Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma.2015
- Author(s)
  Nakamura T, Miyabe H, Hyodo M, Sato Y, Hayakawa Y, Harashima H.
- Journal Title
  
  J Control Release
  
  Volume: 216 Pages: 149-157
- DOI
  10.1016/j.jconrel.2015.08.026
- NAID
  120005853062
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830101, KAKENHI-PROJECT-24350087
[Journal Article] Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING.2015
- Author(s)
  Kobayashi H, Kobayashi CI, Nakamura-Ishizu A, Karigane D, Haeno H, Yamamoto KN, Sato T, Ohteki T, Hayakawa Y, Barber GN, Kurokawa M, Suda T, and Takubo K.
- Journal Title
  
  Cell Reports
  
  Volume: 111 Issue: 1 Pages: 71-84
- DOI
  10.1016/j.celrep.2015.02.066
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15150, KAKENHI-PUBLICLY-15H01485, KAKENHI-PUBLICLY-15H01508, KAKENHI-ORGANIZER-26115001, KAKENHI-PLANNED-26115005, KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-26253029, KAKENHI-PROJECT-15H04861, KAKENHI-PROJECT-24350087, KAKENHI-PLANNED-26115006
[Journal Article] Activation of the Stimulator of Interferon Genes (STING) adaptor attenuates experimental autoimmune encephalitis.2014
- Author(s)
  Henrique Lemos, Lei Huang, Phillip R. Chandler, Eslam Mohamed, Guilherme R. Souza, Lingqian Li, Gabriela Pacholczyk, Glen N. Barber, Yoshihiro Hayakawa, David H. Munn, and Andrew L. Mellor
- Journal Title
  
  J. Immunology
  
  Volume: 192 Issue: 12 Pages: 5571-5578
- DOI
  10.4049/jimmunol.1303258
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24350087
[Journal Article] A new adjuvant delivery system ‘cyclic di-GMP/YSK05 liposome’ for cancer immunotherapy.2014
- Author(s)
  Hiroko Miyabe, Mamoru Hyodo, Takashi Nakamura, Yusuke Sato, Yoshihiro Hayakawa, and Hideyoshi Harashima
- Journal Title
  
  J. Controlled Release
  
  Volume: 184 Pages: 20-27
- DOI
  10.1016/j.jconrel.2014.04.004
- NAID
  120005512017
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24350087, KAKENHI-PROJECT-26830101
[Journal Article] STING Ligand c-di-GMP Improves Cancer Vaccination against Metastatic Breast Cancer.2014
- Author(s)
  Dinesh Chandra, Wilber Quispe-Tintaya, Arthee Jahangir, Denise Asafu-Adjei, Liyssa Ramos, Herman O. Sintim, Jie Zhou, Yoshihiro Hayakawa, David K. R. Karaolis, and Claudia Gravekamp
- Journal Title
  
  Cancer Immunology Research
  
  Volume: 2 Issue: 9 Pages: 901-910
- DOI
  10.1158/2326-6066.cir-13-0123
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24350087
[Journal Article] c-di-GMP Enhances Protective Innate Immunity in a Murine Model of Pertussis.2014
- Author(s)
  S. Elahi, J. Van Kessel, T. G. Kiros, S. Strom, Y Hayakawa, M.Hyodo, L. A. Babiuk, and V. Gerdts
- Journal Title
  
  PLOS ONE
  
  Volume: 9 Issue: 10 Pages: e109778-e109778
- DOI
  10.1371/journal.pone.0109778
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24350087, KAKENHI-PROJECT-26830101
[Journal Article] The innate DNA sensor cGAS produces a non-canonical cyclic-di-nucleotide that activates human STING.2013
- Author(s)
  Elie J. Diner, Dara L. Burdette, Stephen C. Wilson, Kathryn M. Monroe, Colleen A. Kellenberger, Mamoru Hyodo, Yoshihiro Hayakawa, Ming C. Hammond, and Russell E. Vance
- Journal Title
  
  Cell Reports
  
  Volume: 3 Issue: 5 Pages: 1355-1361
- DOI
  10.1016/j.celrep.2013.05.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24350087
[Journal Article] Cutting Edge: DNA Sensing via the Stimulator of Interferon Genes (STING) Adaptor in Myeloid Dendritic Cells Induces Potent Tolerogenic Responses.2013
- Author(s)
  abak Baban, Glen N. Barber, Yoshihiro Hayakawa, Tracy L. McGaha, David H. Munn, and Andrew L. Mellor
- Journal Title
  
  J. Immunology
  
  Volume: 191 Pages: 3509-3513
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24350087
[Journal Article] STING is a direct innate immune sensor of cyclic dinucleotides2011
- Author(s)
  Dara L. Burdette, Kathryn M. Monroe, Katia Sotelo-Troha, Barbara Eckert, Mamoru Hyodo, Yoshihiro Hayakawa, and Russell E. Vance
- Journal Title
  
  Nature
  
  Volume: 478 Pages: 515-518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] Cyclic di-GMP Signaling Regulates Invasion of Ehrlichia chaffeensis into Human Monocytes.2011
- Author(s)
  Y.Kumagai, J.Matsuo, Y.Hayakawa, Y.Rikihisa
- Journal Title
  
  J.Bacteriology
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article]2011
- Author(s)
  Joshua E. Pitzer, Syed Z. Sultan, Yoshihiro Hayakawa, Gerry Hobbs, Michael R. Miller, and Md A. Motaleb
- Journal Title
  
  Infect. Immun
  
  Volume: 79 Pages: 1815-1825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] Analysis of the Borrelia burgdorferi cyclic-di-GMP binding protein PlzA revealsa role in motility and virulence.2011
- Author(s)
  J.E.Pitzer, S.Z.Sultan, Y.Hayakawa, G, Hobbs, M.R.Miller, M.A.Motaleb
- Journal Title
  
  Infection and Immunity
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] The N-Ethyl-N-nitrosourea-induced Goldenticket (Gt) Mouse Mutant Reveals an Essential Function of Sting (Tmem173, Mita, Mpys, Eris) in the in vivo Interferon Response to Listeria monocytogenes and Cyclic-di-nucleotides.2011
- Author(s)
  J.-D.Sauer, K.Sotelo-Troha, J.von Moltke, K.M.Monroe, C.S.Rae, S.W.Brubaker, M.Hyodo, Y.Hayakawa, J.J.Woodward, D.A.Portnoy, Russell E.Vance
- Journal Title
  
  Infection and Immunity
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] Cyclic dimeric GMP Signaling Regulates Intracellular Aggregation, Sessility, and Growth of Ehrlichia chaffeensis2011
- Author(s)
  Yumi Kumagai, Junji Matsuo, Zhihui Cheng, Yoshihiro Hayakawa, and Yasuko Rikihisa
- Journal Title
  
  Infect. Immun
  
  Volume: 79 Pages: 3905-3912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] Molecular oxygen regulates the enzymatic activity of a heme-containing diguanylate cyclase(HemDGC) for the synthesis of cyclic di-GMP2010
- Author(s)
  Hitomi Sawai, Shiro Yoshioka, Takeshi Uchidda, Mamoru Hyodo, Yoshihiro Hayakawa, Koichiro Ishimori, and Shigetoshi Aono
- Journal Title
  
  Biochem. Biophys. Acta
  
  Volume: 1804 Pages: 166-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] Cyclic di-GMP Signaling Regulates Invasion of Ehrlichia chaffeensis into Human Monocytes2010
- Author(s)
  Yumi Kumagai, Junji Matsuo, Yoshihiro Hayakawa, and Yasuko Rikihisa
- Journal Title
  
  J. Bacteriology
  
  Volume: 192 Pages: 4122-4133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] Molecular Oxygen Regulates the Enzymatic Activity of HemDGC, a Heme-containing Diguanylate Cyclase, for the Synthesis of Cyclic di-GMP2010
- Author(s)
  H.Sawai, S.Yoshioka, T.Uchida, M.Hyodo, Y.Hayakawa, K.Ishimori, S.Aono
- Journal Title
  
  Biochem.Biophys.Acta 1804
  
  Pages: 116-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] Biochemical and physiological characterization of a BLUF protein/EAL protein complex involved in blue light-dependent degradation of cyclic diguanylate in the purple bacterium Rhodopseudomonas palustris.2010
- Author(s)
  T.Kanazawa, S.Ren, M.Maekawa, K.Hasegawa, F.Arisaka, M.Hyodo, Y.Hayakawa, H.Ohta, S.Masuda
- Journal Title
  
  Biochemistry
  
  Volume: 49 Pages: 10647-10655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] Gas-phase isolation of diethyl guanosine 5'-monophosphate and its conformational assignment.2010
- Author(s)
  H.Asami. M.Tsukamoto, Y.Hayakawa, H.Saigusa
- Journal Title
  
  Physical Chemistry Chemical Physics
  
  Volume: 12 Pages: 13918-13921
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] Molecular Oxygen Regulates the Enzymatic Activity of HemDGC, a Heme-containing Diguanylate Cyclase, for the Synthesis of Cyclic di-GMP.2010
- Author(s)
  H.Sawai, S.Yoshioka, T.Uchida, M.Hyodo, Y.Hayakawa, K.Ishimori, S.Aono
- Journal Title
  
  Biochem.Biophys.Acta
  
  Volume: 1804 Pages: 166-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] Effect of Cyclic Bis(3'-5')diguanylic Acid and Its Analogs on Bacterial Biofilm Formation2010
- Author(s)
  Y.Ishihara, M.Hyodo, Y.Hayakawa, T.Kamegaya, K.Yamada, A.Okamoto, T.Hasegawa, M.Ohta
- Journal Title
  
  FEMS Microbiology Lett. 301
  
  Pages: 193-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] C-di-GMP as a Vaccine Adjuvant Enhances Protection Against Systemic Methicillin-Resistant Staphylococcus aureus(MRSA) Infection Vaccine2009
- Author(s)
  Dong-Liang Hu, Kouji Narita, Mamoru Hyodo, Yoshihiro Hayakawa, Akio Nakane, and David K. R. Karaolis
- Journal Title
  
  Vaccine
  
  Volume: 27 Pages: 4867-4873
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] Effect of cyclic bis(3'-5') diguanylic acid and its analogs on bacterial biofilm formation2009
- Author(s)
  Y. Ishihara, M. Hyodo, Y. Hayakawa, T. Kamegaya, K. Yamada, A. Okamoto, T. Hasegawa, and M. Ohta
- Journal Title
  
  FEMS Microbiology Lett
  
  Volume: 301 Pages: 193-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] Peptide-nucleic acids(PNAs)with pyrimido[4, 5-d]pyrimidine-2, 4, 5, 7-(1H, 3H, 6H, 8H)-tetraone as a universal base : their synthesis and binding affinity for oligodeo xyribonucleotides2009
- Author(s)
  T.Hirano, K.Kuroda, M.Kataoka, Y.Hayakawa
- Journal Title
  
  Org.Biomol.Chem. 7
  
  Pages: 2905-2911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] Anaplasma phagocytophilum PleC and PleD Diguanylate Cyclase Two-Component System and Role of Cyclic Di-DMP in Host-Cell Infection2009
- Author(s)
  T.-H.Lai, Y.Kumagai, M.Hyodo, Y.Hayakawa, Y.Rikihisa
- Journal Title
  
  J.Bacteriology 191
  
  Pages: 693-700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] c-di-GMP as a Vaccine Adjuvant Enhances Protection Against Systerrc Methicillin-Resistant Staphylococcus aureus (MRS4) Infection Vaccine.2009
- Author(s)
  D.-L.Hu, K.Narita, M.Hyodo, Y.Hayakawa, A.Nakane, D.K.R.Karaolis
- Journal Title
  
  Vaccine 27
  
  Pages: 4867-4873
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP2009
- Author(s)
  Sarah M. McWhirter, Roman Barbalat, Kathryn M. Monroe, Mary F. Fontana, Mamoru Hyodo, Nathalie T. Joncker, Ken J. Ishi, Shizuo Akira, Marco Colonna, Zhijian J. Chen, Katherine A. Fitzgerald, Yoshihiro Hayakawa, and Russell E. Vance
- Journal Title
  
  J. Exp. Med.
  
  Volume: 206 Pages: 1899-1911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] The Anaplasma phagocytophilum PleC histidine kinase and PleD diguanylate cyclase two-component system and role of cyclic di-GMP in host cell infection.2009
- Author(s)
  Lai, T-H., Kumagai Y., Hyodo, M., Hayakawa, Y., Rikihisa, Y.
- Journal Title
  
  J. Bacteriol. 191
  
  Pages: 693-700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP2009
- Author(s)
  S.M.McWhirter, R.Barbalat, K.M.Monroe, M.F.Fontana, M.Hyodo, K.J.Ishii, S.Akira, M.Colonna, Z.J.Chen, K.A.Fitzgerald, Y.Hayakawa, R.E.Vance
- Journal Title
  
  J.Exp.Med. 206
  
  Pages: 1899-1911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] Anaplasmaa phagocytophilum PleC and PleD diguanylate cyclase two-component system and role of cyclic di-GMP in host-cell infection2009
- Author(s)
  Tzung-Huei Lai, Yumi Kumagai, Mamoru Hyodo, Yoshihiro Hayakawa, and Yasuko Rikihisa
- Journal Title
  
  J. Bacteriology
  
  Volume: 191 Pages: 693-700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] c-di-GMP as a Vaccine Adjuvant Enhances Protection Against Systemic Methicill in-Resistant Staphylococcus aureus(MRSA)Infection Vaccine2009
- Author(s)
  D.-L.Hu, K.Narita, M.Hyodo, Y.Hayakawa, A.Nakane, D.K.R.Karaolis
- Journal Title
  
  Vaccine 27
  
  Pages: 4867-4873
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] バイオフィルム阻害薬の探索2009
- Author(s)
  兵藤守, 早川芳宏
- Journal Title
  
  臨床と微生物 36
  
  Pages: 423-429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] c-di-GMP is an effective immunomodulator and vaccine adjuvant againstpneumococcal infection.2008
- Author(s)
  Ogunniyi, A. D., Paton, J. C, Kirby, A. C, McCullers, J. A., Cook, J., Hyodo, M., Hayakawa. Y., Karaolis, D. K. R.
- Journal Title
  
  Vaccine 26
  
  Pages: 4676-4685
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] C-di-GMP is an effective immuno, odulator and vaccine adjuvant against pneumococcal infection2008
- Author(s)
  A. D. Ogunniyi, J. P. Paton, A. C. Kieby, J. A. McCullers, J. Cook, M. Hyodo, Y. Hayakawa, and D. K. R. Karaolis
- Journal Title
  
  Vaccine
  
  Volume: 26 Pages: 4676-4685
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] バイオフィルム感染症特効薬としての可能性を秘めるc-di-GMP 高効率合成法が開いた生理活性探索の扉。2008
- Author(s)
  早川芳宏
- Journal Title
  
  化学と生物 46
  
  Pages: 444-446
- NAID
  10024333884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Journal Article] Bacterial c-di-GMP is an Immunostimulatory Molecule.2007
- Author(s)
  D.K.Karaolis, T.K.Means, D.Yang, M.Takahashi, T.Yoshimura, E.Muraille, D.Philpott, J.T.Schroeder, M.Hyodo, Y.Hayakawa, B.G.Talbot, E.Brouiliette, F.Malouin
- Journal Title
  
  J. Immunology 178・8
  
  Pages: 2171-2181
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Bacterial c-di-GMP is an Immunostimulatory Molecule.2007
- Author(s)
  D.K.Karaolis, T.K.Means, D.Yang, M.Takahashi, T.Yoshimura, E.Muraille, D.Philpott, J.T.Schroeder, M.Hyodo, Y.Hayakawa, B.G.Talbot, E..Brouiliette, F.Malouin
- Journal Title
  
  J. Immunology 178・8
  
  Pages: 2171-2181
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Bacterial c-di-GMP is an Immunostimulatory Molecule.2007
- Author(s)
  D.K.Karaolis, T.K.Means, D.Yang, M.Takahashi, T.Yoshimura, E.Muraille, D.Philpott, J.T.Schroeder, M.Hyodo, Y.Hayakawa, B.G Talbot, E.Brouiliette, F.Malouin.
- Journal Title
  
  J. Immunology 178
  
  Pages: 2171-2181
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Synthesis of cyclic bis(3'-5')diguanylic acid (c-di-GMP)analogs.2006
- Author(s)
  M.Hyodo, Y.Sato, Y.Hayakawa
- Journal Title
  
  Tetrahedron 62・13
  
  Pages: 3089-3094
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Control of formation and cellular detachment from Shewanella oneidensis MR-1 biofilms by cyclic-di-GMP.2006
- Author(s)
  K.M.Thormann, S.Duttler, R.M.Saville, M.Hyodo, S.Shukla, Y.Hayakawa, A.M.Spormann
- Journal Title
  
  J. Bacteriology 188・7
  
  Pages: 2681-2691
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] A strategy for the stereoselective preparation of dithymidine phosphorothioates with an R or S configuration of the stereogenic phosphorus atom and its application to the synthesis of oligodeoxyribonucleotides with stereochemically pure phosphate/phosphorotioate chimeric backbones.2006
- Author(s)
  Y.Hayakawa, Y.Hirabayashi, M.Hyodo, S.Yamashita, T.Matsunami, D.-M.Cui, R.Kawai, H.Kodama.
- Journal Title
  
  Eur. J. Org. Chem.
  
  Pages: 3834-3844
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis(3'-5')-cyclic di-GMP in virulence.2006
- Author(s)
  H.Kulesekara, V.Lee, A.Brencic, N.Liberati, J.Urbach, S.Miyata, D.G.Lee, A.N.Neely, M.Hyodo, Y.Hayakawa, F.M.Ausubel, S.Lory
- Journal Title
  
  Proc. Natl. Acad. Sci. U.S.A. 103・8
  
  Pages: 2839-2844
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] 環状ビス(3'-5')ジグアニル酸(c-di-GMP)および類縁体の有機合成、化学的性質、および生物活性。2006
- Author(s)
  兵藤守, 早川芳宏, D.K.R.Karaolis
- Journal Title
  
  有機合成化学協会誌 64・4
  
  Pages: 359-370
- NAID
  10018131558
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Organic Synthesis, Chemical Properties, and Biological Activities of Cyclic bis(3'-5')Diguanylic Acid (c-di-GMP) and Its Analogs.2006
- Author(s)
  M.Hyodo, Y.Hayakawa, D.K.R.Karaolis.
- Journal Title
  
  J. Synth. Org. Chem., Jpn. 64
  
  Pages: 359-370
- NAID
  10018131558
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Genome wide transcriptional profile of Escherichia coli in response to high levels of the second messenger c-di-GMP.2006
- Author(s)
  M.M.Mendez-Ortiz, M.Hyodo, Y.Hayakawa, J.Membrillo-Hernandez.
- Journal Title
  
  J. Biol. Chem. 281
  
  Pages: 8090-8099
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Synthesis of cyclic bis(3'-5')diguanylic acid(c-di-GMP) analogs2006
- Author(s)
  M.Hyodo, Y.Sato, Y.Hayakawa
- Journal Title
  
  Tetrahedron 62
  
  Pages: 3089-3094
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis(3'-5')-cyclic di-GMP in virulence.2006
- Author(s)
  H.Kulesekara, V.Lee, A.Brencic, N.Liberati, J.Urbach, S.Miyata, D.G Lee, A.N.Neely, M.Hyodo, Y.Hayakawa, F.M.Ausubel, S.Lory.
- Journal Title
  
  Proc. Natl. Acad. Sci. U.S.A. 103
  
  Pages: 2839-2844
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] A ribonucleoside with pyrimido[4,5-djpyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone as a nucleobase, which universally binds to natural nucleosides.2006
- Author(s)
  K.Kuroda, H.Kodama, M.Kataoka, Y.Hayakawa
- Journal Title
  
  Nucleic Acids Symp. Ser. 50
  
  Pages: 17-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Synthesis of cyclic bis(3'-5')diguanylic acid (c-di-GMP) analogs.2006
- Author(s)
  M.Hyodo, Y.Sato, Y.Hayakawa
- Journal Title
  
  Tetrahedron 62・13
  
  Pages: 3089-3094
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] 環状ビス(3'-5')ジグアニル酸(c-di-GMP)および類縁体の有機合成、化学的性質、および生物活性。2006
- Author(s)
  兵藤守, 早川芳宏, D.K.R. Karaolis
- Journal Title
  
  有機合成化学協会誌 64・4
  
  Pages: 359-370
- NAID
  10018131558
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] A ribonucleoside with pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H, 8H)-tetraone as a nucleobase, which universally binds to natural nucleosides.2006
- Author(s)
  K.Kuroda, H.Kodama, M.Kataoka, Y.Hayakawa.
- Journal Title
  
  Nucleic Acids Symp. Ser. 50
  
  Pages: 17-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] A ribonucleoside with pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone as a nucleobase, which universally binds to natural nucleosides.2006
- Author(s)
  K.Kuroda, H.Kodama, M.Kataoka, Y.Hayakawa
- Journal Title
  
  Nucleic Acids Symp. Ser. 50
  
  Pages: 17-18
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Genome wide transcriptional profile of Escherichia coli in response to high levels of the second messenger c-di-GMP.2006
- Author(s)
  M.M.Mendez-Ortiz, M.Hyodo, Y.Hayakawa, J.Membrillo-Hernandez
- Journal Title
  
  J. Biol. Chem. 281・12
  
  Pages: 8090-8099
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Control of formation and cellular detachment from Shewanella oneidensis MR-1 biofilms by cyclic-di-GMP.2006
- Author(s)
  K.M.Thormann, S.Duttler, R.M.Saville, M.Hyodo, S.Shukla, Y.Hayakawa, A.M.Spormann.
- Journal Title
  
  J. Bacteriology 188
  
  Pages: 2681-2691
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role of bis(3'-5')-cyclic di-GMP in virulence2006
- Author(s)
  H.Kulesekaha, V.Lee, A.Brencic, N.Liberati, J.Urbach, S.Miyata, D.G.Lee, A.N.Neely, M.Hyodo, Y.Hayakawa, F.M.Ausebel, S.Lory
- Journal Title
  
  Proc.Natl.Acad.Sci.U.S.A. 103
  
  Pages: 2839-2844
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] A strategy for the stereoselective preparation of dithymidine phosphorothioates with an R or S configuration of the stereogenic phosphorus atom and its application to the synthesis of oligodeoxyribonucleotides with stereochemically pure phosphate/phosphorotioate chimeric backbones.2006
- Author(s)
  Y.Hayakawa, Y.Hirabayashi, M.Hyodo, S.Yamashita, T.Matsunami, D.-M.Cui, R.Kawai, H.Kodama
- Journal Title
  
  Eur. J. Org. Chem. 24
  
  Pages: 3834-3844
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Synthesis of cyclic bis(3'-5')diguanylic acid (c-di-GMP) analogs.2006
- Author(s)
  M.Hyodo, Y.Sato, Y.Hayakawa.
- Journal Title
  
  Tetrahedron 62
  
  Pages: 3089-3094
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Chemical behavior of bis(3'-5')diguanylic acid in aqueous solutions.2005
- Author(s)
  M.Hyodo, Y.Sato, Y.Hayakawa, D.K.R.Karaolis.
- Journal Title
  
  Nucleic Acids Symp. Ser. 49
  
  Pages: 117-118
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] A Solid Support with a Hydroxyallyl Linker, Full Parts of Which are Potentially Reusable for the Synthesis of Oligonucleotides.2005
- Author(s)
  M.Hyodo, M.Morimura, Y.Hayakawa.
- Journal Title
  
  Nucleosides, Nucleotides, Nucleic Acids 49
  
  Pages: 585-588
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Novel Synthesis and Characterization of Bioconjugate Block Copolymers Having Oligonucleotides.2005
- Author(s)
  A.Noro, Y.Nagata, M.Tsukamoto, Y.Hayakawa, A.Takano, Y.Matsushita.
- Journal Title
  
  Biomacromolecules 6
  
  Pages: 2328-2333
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Carboxylic Acids as Promoters for Internucleotide-Bond Formation via Condensation of a Nucleoside Phosphoramidite and a Nucleoside2005
- Author(s)
  Y.Hayakawa 他4名
- Journal Title
  
  Tetrahedron 61
  
  Pages: 2203-2209
- Data Source
  KAKENHI-PROJECT-16011223
[Journal Article] Bis[3-(triethoxysilyl)propyl] Tetrasulfide : The First Liquid Sulfur-Transferring Agent Useful for Conversion of Nucleoside ….2005
- Author(s)
  M.Hyodo, Y.Hayakawa 他5名
- Journal Title
  
  Tetrahedron 61
  
  Pages: 965-970
- Data Source
  KAKENHI-PROJECT-16011223
[Journal Article] Bis[3-(triethoxysilyl)propyl] Tetrasulfide : The First Liquid Sulfur-Transferring Agent Useful for Conversion of Nucleoside Phosphites to the Phosphorothioates.2005
- Author(s)
  M.Hyodo, Y.Sato, S.Yamashita, A.Hattori, E.Kambe, M.Kataoka, Y.Hayakawa
- Journal Title
  
  Tetrahedron 61・4
  
  Pages: 965-970
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Synthesis of a peptide nucleic acid oligomer with pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone as a nucleobase.2005
- Author(s)
  M.Kataoka, T.Hirano, K.Kuroda, Y.Hayakawa
- Journal Title
  
  Nucleic Acids Symp. Ser. 49
  
  Pages: 121-122
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] 3',5'-Cyclic Diguanylic Acid Reduces the Virulence of Biofilm-Forming Staphylococcus aureus Strains in a Mouse Model of Mastitis Infection.2005
- Author(s)
  E.Brouillette, M.Hyodo, Y.Hayakawa, D.K.R.Karaolis, F.Malouin
- Journal Title
  
  Antimicrobial Agents and Chemotherapy 49・8
  
  Pages: 3109-3113
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone as a novel universal base.2005
- Author(s)
  M.Kataoka, T.Hirano, K.Kuroda, Y.Hayakawa.
- Journal Title
  
  Nucleic Acids Symp. Ser. 49
  
  Pages: 119-120
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Synthesis of a peptide nucleic acid oligomer with pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone as a nucleobase.2005
- Author(s)
  M.Kataoka, T.Hirano, K.Kuroda, Y.Hayakawa.
- Journal Title
  
  Nucleic Acids Symp. Ser. 49
  
  Pages: 121-122
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Carboxylic Acids as Promoters for Internucleotide-Bond Formation via Condensation of a Nucleoside Phosphoramidite and a Nucleoside : Relationship between the Acidity and the Activity of the Promoter.2005
- Author(s)
  Y.Hayakawa, T.Iwase, E.J.Nurminen, M.Tsukamoto, M.Kataoka
- Journal Title
  
  Tetrahedron 61・8
  
  Pages: 2203-2209
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Bis[3-(triethoxysilyl)propyl] Tetrasulfide : The First Liquid Sulfur-Transferring Agent Useful for Conversion of Nucleoside Phosphites to the Phosphorothioates.2005
- Author(s)
  M.Hyodo, Y.Sato, S.Yamashita, A.Hattori, E.Kambe, M.Kataoka, Y.Hayakawa.
- Journal Title
  
  Tetrahedron 61
  
  Pages: 965-970
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] 3',5'-Cyclic Diguanylic Acid (c-di-GMP) Inhibits Basal and Growth Factor-Stimulated Human Colon Cancer Cell Proliferation.2005
- Author(s)
  D.K.R.Karaolis, K.Cheng, M.Lipsky, A.Elnabawi, J.Cataslano, M.Hyodo, Y.Hayakawa, J.-P.Raufman.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 329
  
  Pages: 40-45
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] c-di-GMP (3'-5'-Cyclic Diguanylic Acid) Inhibits Staphylococcus aureus Cell-Cell Interactions and Biofilm Formation.2005
- Author(s)
  D.K.R.Karaolis, M.H.Rashid, R.Chythanya, W.Luo, M.Hyodo, Y.Hayakawa
- Journal Title
  
  Antimicrobial Agents and Chemotherapy 49・3
  
  Pages: 1029-1038
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Carboxylic Acids as Promoters for Intemucleotide-Bond Formation via Condensation of a Nucleoside Phosphoramidite and a Nucleoside : Relationship between the Acidity and the Activity of the Promoter.2005
- Author(s)
  Y.Hayakawa, T.Iwase, E.J.Nurminen, M.Tsukamoto, M.Kataoka.
- Journal Title
  
  Tetrahedron 61
  
  Pages: 2203-2209
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Carboxylic Acids as Promoters for Internucleotide-Bond Formation via Condensation of a Nucleoside Phosphoramidite and a Nucleoside2005
- Author(s)
  Y.Hayakawa 他4名
- Journal Title
  
  Tetrahedron 61
  
  Pages: 2203-2209
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] 3',5'-Cyclic Diguanylic Acid (c-di-GMP) Inhibits Basal and Growth Factor-Stimulated Human Colon Cancer Cell Proliferation2005
- Author(s)
  D.K.R.Karaolis, Y.Hayakawa 他6名
- Journal Title
  
  Biochem.Biophys.Res.Commun. 329
  
  Pages: 40-45
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] A Solid Support with a Hydroxyallyl Linker, Full Parts of Which are Potentially Reusable for the Synthesis of Oligonucleotides.2005
- Author(s)
  M.Hyodo, M.Morimura, Y.Hayakawa
- Journal Title
  
  Nucleosides, Nucleotides, Nucleic Acids 24・5-7
  
  Pages: 585-588
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] c-di-GMP (3'-5'-Cyclic Diguanylic Acid) Inhibits Staphylococcus aureus Cell-Cell Interaction and Biofilm Formation2005
- Author(s)
  D.K.R.Karaolis, Y.Hayakawa 他4名
- Journal Title
  
  Antimicrobial Agents and Chemotherapy 49
  
  Pages: 1029-1038
- Data Source
  KAKENHI-PROJECT-16011223
[Journal Article] 3',5'-Cyclic Diguanylic Acid (c-di-GMP) Inhibits Basal and Growth Factor-Stimulated Human Colon Cancer Cell Proliferation2005
- Author(s)
  D.K.R.Karaolis, Y.Hayakawa 他6名
- Journal Title
  
  Biochem.Biophys.Res.Commun. 329
  
  Pages: 40-45
- Data Source
  KAKENHI-PROJECT-16011223
[Journal Article] Bis[3-(triethoxysilyl)propyl] Tetrasulfide : The First Liquid Sulfur-Transferring Agent Useful for Conversion of Nucleoside ….2005
- Author(s)
  M.Hyodo, Y.Hayakawa 他5名
- Journal Title
  
  Tetrahedron 61
  
  Pages: 965-970
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Chemical behavior of bis(3'-5')diguanylic acid in aqueous solutions.2005
- Author(s)
  M.Hyodo, Y.Sato, Y.Hayakawa, D.K.R.Karaolis
- Journal Title
  
  Nucleic Acids Symp. Ser. 49
  
  Pages: 117-118
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone as a novel universal base.2005
- Author(s)
  M.Kataoka, T.Hirano, K.Kuroda, Y.Hayakawa
- Journal Title
  
  Nucleic Acids Symp. Ser. 49
  
  Pages: 119-120
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Utility of azolium triflates as promoters for the condensation of a nucleoside phosphoramidite and a nucleoside in the Agrawal's stereoselective synthesis of nucleoside phosphorothioates.2005
- Author(s)
  M.Hyodo, H.Ando, H.Nishitani, A.Hattori, H.Hayakawa, M.Kataoka, Y.Hayakawa
- Journal Title
  
  Eur. J. Org. Chem. 24
  
  Pages: 5216-5223
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Utility of azolium triflates as promoters for the condensation of a nucleoside phosphoramidite and a nucleoside in the Agrawal's stereoselective synthesis of nucleoside phosphorothioates2005
- Author(s)
  M.Hyodo, H.Ando, H.Nishitani, A.Hattori, H.Hayakawa, M.Kataoka, Y.Hayakawa
- Journal Title
  
  Eur.J.Org.Chem.
  
  Pages: 5216-5223
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] 3',5'-Cyclic Diguanylic Acid Reduces the Virulence of Biofilm-Forming Staphylococcus aureus Strains in a Mouse Model of Mastitis Infections2005
- Author(s)
  E.Brouillette, M.Hyodo, Y.Hayakawa, D.K.R.Karaolis, F.Malouin
- Journal Title
  
  Antimicrobial Agents and Chemotherapy 49
  
  Pages: 3109-3113
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Chemical behavior of bis(3'-5')diguanylic acid in aqueous solutions2005
- Author(s)
  M.Hyodo, Y.Sato, Y.Hayakawa, D.K.R.Karaolis
- Journal Title
  
  Nucleic Acids Symp.Ser. 49
  
  Pages: 117-118
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Novel Synthesis and Characterization of Bioconjugate Block Copolymers Having Oligonucleotides2005
- Author(s)
  A.Noro, Y.Nagata, M.Tsukamoto, Y.Hayakawa, A.Takano, Y.Matsushita
- Journal Title
  
  Biomacromolecules 6
  
  Pages: 2328-2333
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone as a novel universal base2005
- Author(s)
  M.Kataoka, H.Hirano, K.Kuroda, Y.Hayakawa
- Journal Title
  
  Nucleic Acids Symp.Ser. 49
  
  Pages: 119-120
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Synthesis of a peptide nucleic acid oligomer with pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone as a nucleobase2005
- Author(s)
  M.Kataoka, H.Hirano, K.Kuroda, Y.Hayakawa
- Journal Title
  
  Nucleic Acids Symp.Scr. 49
  
  Pages: 121-122
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] 3',5'-Cyclic Diguanylic Acid Reduces the Virulence of Biofilm-Forming Staphylococcus aureus Strains in a Mouse Model of Mastitis Infection.2005
- Author(s)
  E.Brouillette, M.Hyodo, Y.Hayakawa, D.K.R.Karaolis, F.Malouin.
- Journal Title
  
  Antimicrobial Agents and Chemotherapy 49
  
  Pages: 3109-3113
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] A Solid Support with a Hydroxyallyl Linker, Full Parts of Which azre Potentially Reusable for the Synthesis of Oligonucleotides2005
- Author(s)
  M.Hyodo, M.Morimura, Y.Hayakawa
- Journal Title
  
  Nucleosides, Nucleotides, Nucleic Acids 24
  
  Pages: 585-588
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] c-di-GMP (3'-5'-Cyclic Diguanylic Acid) Inhibits Staphylococcus aureus Cell-Cell Interaction and Biofilm Formation2005
- Author(s)
  D.K.R.Karaolis, Y.Hayakawa 他4名
- Journal Title
  
  Antimicrobial Agents and Chemotherapy 49
  
  Pages: 1029-1038
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Novel Synthesis and Characterization of Bioconjugate Block Copolymers Having Oligonucleotides.2005
- Author(s)
  A.Noro, Y.Nagata, M.Tsukamoto, Y.Hayakawa, A.Takano, Y.Matsushita
- Journal Title
  
  Biomacromolecules 6・4
  
  Pages: 2328-2333
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] 3',5'-Cyclic Diguanylic Acid (c-di-GMP) Inhibits Basal and Growth Factor-Stimulated Human Colon Cancer Cell Proliferation.2005
- Author(s)
  D.K.R.Karaolis, K.Cheng, M.Lipsky, A.Elnabawi, J.Cataslano, M.Hyodo, Y.Hayakawa, J.-P.Raufman
- Journal Title
  
  Biochem. Biophys. Res. Commun. 329・1
  
  Pages: 40-45
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Utility of azolium triflates as promoters for the condensation of a nucleoside phosphoramidite and a nucleoside in the Agrawal's stereoselective synthesis of nucleoside phosphorothioates.2005
- Author(s)
  M.Hyodo, H.Ando, H.Nishitani, A.Hattori, H.Hayakawa.M.Kataoka, Y.Hayakawa.
- Journal Title
  
  Eur. J. Org. Chem.
  
  Pages: 5216-5223
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] c-di-GMP (3'-5'-Cyclic Diguanylic Acid) Inhibits Staphylococcus aureus Cell-Cell Interactions and Biofilm Formation.2005
- Author(s)
  D.K.R.Karaolis, M.H.Rashid, R.Chythanya, W.Luo, M.Hyodo, Y.Hayakawa.
- Journal Title
  
  Antimicrobial Agents and Chemotherapy 49
  
  Pages: 1029-1038
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] An Improved Method for Synthesis of Cyclic Bis(3'-5')diguanylic Acid (c-di-GMP).2004
- Author(s)
  M.Hyodo, Y.Hayakawa.
- Journal Title
  
  Bull. Chem. Soc. Jpn. 77
  
  Pages: 2089-2093
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] An Improved Method for Synthesis of Cyclic Bis(3'-5') diguanylic Acid (c-di-GMP)2004
- Author(s)
  M.Hyodo, Y.Hayakawa
- Journal Title
  
  Bull.Chem.Soc.Jpn. 77
  
  Pages: 2089-2093
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Internucleotide-linkage Formation via the Phosphoramidite Method Using a Carboxylic Acid as a Promoter.2004
- Author(s)
  M.Tsukamoto, E.J.Nurminen, T.Iwase, M.Kataoka, Y.Hayakawa
- Journal Title
  
  Nucleic Acids Symp. Ser. 48
  
  Pages: 25-26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] An Improved Method for Synthesis of Cyclic Bis(3'-5')diguanylic Acid (c-di-GMP).2004
- Author(s)
  M.Hyodo, Y.Hayakawa
- Journal Title
  
  Bull. Chem. Soc. Jpn. 77・11
  
  Pages: 2089-2093
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] Internucleotide-linkage Formation via the Phosphoramidite Method Using a Carboxylic Acid as a Promoter.2004
- Author(s)
  M.Tsukamoto, E.J.Nurminen, T.Iwase, M.Kataoka, Y.Hayakawa.
- Journal Title
  
  Nucleic Acids Symp. Ser 48
  
  Pages: 25-26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Journal Article] An Improved Method for Synthesis of Cyclic Bis(3'-5') diguanylic Acid (c-di-GMP)2004
- Author(s)
  M.Hyodo, Y.Hayakawa
- Journal Title
  
  Bull.Chem.Soc.Jpn. 77
  
  Pages: 2089-2093
- Data Source
  KAKENHI-PROJECT-16011223
[Journal Article] The N-Ethyl-N-nitrosourea-induced Goldenticket(Gt) Mouse Mutant Reveals an Essential Function of Sting(Tmem173, Mita, Mpys, Eris) in the in vivo Interferon Response to Listeria monocytogenes and Cyclic-di-nucleotides
- Author(s)
  John-Demian Sauer, Katia Sotelo-Troha, Jakob von Moltke, Katharyn M. Monroe, Chris S. Rae, Sky W. Brubaker, Mamoru Hyodo, Yoshihiro Hayakawa, Joshua J. Woodward, Daniel A. Portnoy, and Russell E. Vance
- Journal Title
  
  Infect. Immun
  
  Volume: 79(1011) Pages: 688-694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350076
[Patent] 核酸固相合成用リンカー及び担体2012
- Inventor(s)
  塚本眞幸, 鈴本紀尊, 早川芳宏, 前田恵里, 森健二郎, 味呑憲二郎
- Industrial Property Rights Holder
  名古屋大学日東電工(株)
- Industrial Property Number
  2012-016895
- Filing Date
  2012-01-30
- Data Source
  KAKENHI-PROJECT-20350076
[Patent] 核酸固相合成用リンカー及び担体2012
- Inventor(s)
  塚本眞幸、鈴木紀尊、早川芳宏、前田恵里、森健二郎、味呑憲二郎
- Industrial Property Rights Holder
  名古屋大学、日東電工(株)
- Industrial Property Number
  2012-016895
- Filing Date
  2012-01-30
- Data Source
  KAKENHI-PROJECT-20350076
[Patent] 核酸固相合成用リンカー及び担体2010
- Inventor(s)
  早川芳宏, 塚本眞幸, 森健二郎, 味呑憲二郎, 前田恵里, 小西達也
- Industrial Property Rights Holder
  名古屋大学日東電工(株)
- Filing Date
  2010-10-20
- Overseas
- Data Source
  KAKENHI-PROJECT-20350076
[Patent] 核酸固相合成用リンカー及び担体2010
- Inventor(s)
  早川芳宏、塚本眞幸、森健二郎、味呑憲二郎、前田恵里、小西達也
- Industrial Property Rights Holder
  名古屋大学、日東電工(株)
- Filing Date
  2010-10-20
- Overseas
- Data Source
  KAKENHI-PROJECT-20350076
[Patent] 核酸固相合成用リンカー及び担体2009
- Inventor(s)
  早川芳宏, 塚本眞幸, 森健二郎, 味呑憲二郎, 前田恵里, 小西達也
- Industrial Property Rights Holder
  日東電工株式会社国立大学法人名古屋大学
- Industrial Property Number
  2009-242445
- Filing Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-20350076
[Patent] 核酸固相合成用リンカー及び担体2009
- Inventor(s)
  早川芳宏、塚本眞幸、森健二郎、味呑憲二郎、前田恵里、小西達也
- Industrial Property Rights Holder
  日東電工株式会社、名古屋大学
- Industrial Property Number
  2009-242445
- Filing Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-20350076
[Patent] ユニバーサル塩基含有ポリマー2005
- Inventor(s)
  片岡正典, 早川芳宏, 平野泰輔
- Industrial Property Rights Holder
  国立大学法人名古屋大学
- Filing Date
  2005-08-30
- Acquisition Date
  2006-08-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Patent] ヌクレオシド誘導体、ヌクレオチド誘導体及びそれらの製造方法2005
- Inventor(s)
  早川芳宏
- Industrial Property Rights Holder
  国立大学法人名古屋大学
- Patent Publication Number
  2006-248949
- Filing Date
  2005-03-09
- Acquisition Date
  2006-09-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Patent] 特許2004
- Inventor(s)
  早川芳宏
- Industrial Property Rights Holder
  名古屋大学
- Industrial Property Number
  2004-325403
- Filing Date
  2004-11-09
- Data Source
  KAKENHI-PROJECT-16350086
[Patent] ヌクレオチド及びその誘導体の製造方法2004
- Inventor(s)
  早川芳宏
- Industrial Property Rights Holder
  国立大学法人名古屋大学
- Patent Publication Number
  2006-131596
- Filing Date
  2004-11-09
- Acquisition Date
  2006-05-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350086
[Patent] 特許2004
- Inventor(s)
  早川芳宏
- Industrial Property Rights Holder
  名古屋大学
- Industrial Property Number
  2004-325403
- Filing Date
  2004-11-09
- Data Source
  KAKENHI-PROJECT-16011223
[Patent] ユニバーサル塩基含有ポリマー2003
- Inventor(s)
  片岡正典, 早川芳宏, 平野泰輔
- Industrial Property Rights Holder
  自然科学研究機構, 名古屋大学
- Industrial Property Number
  2005-248586
- Filing Date
  2003-08-30
- Data Source
  KAKENHI-PROJECT-16350086
[Presentation] Intact laser desorption of guanosine 5'-monophosphate facilitated by the phosphoe sterification-Conformational analysis by infrared vibrational spectroscopy2010
- Author(s)
  H.Asami, A.Motoda, M.Tsukamoto, Y.Hayakawa, H.Saigusa
- Organizer
  Molecular and Ionic Clusters Conference 2010
- Place of Presentation
  新潟
- Year and Date
  2010-09-08
- Data Source
  KAKENHI-PROJECT-20350076
[Presentation] グアニンヌクレオチドのリン酸基エステル化による非破壊的気化と赤外振動分光2010
- Author(s)
  浅見祐也, 元田彩香, 塚本眞幸, 早川芳宏, 三枝洋之
- Organizer
  第4回分子科学討論会2010
- Place of Presentation
  大阪
- Year and Date
  2010-09-16
- Data Source
  KAKENHI-PROJECT-20350076
[Presentation] Non-destructive vaporization of GMP facilitated by the phosphoesterification : Conformational preference in the gas phase2010
- Author(s)
  Hiroya Asami, Ayaka Motoda, Masaki Tsukamoto, Yoshihiro Hayakawa, and Hiroyuki Saigusa
- Organizer
  The 37^<th> International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Yokohama
- Year and Date
  2010-11-11
- Data Source
  KAKENHI-PROJECT-20350076
[Presentation] Non-destructive vaporization of GMP facilitated by the phosphoesterification : Conformational preference in the gas phase2010
- Author(s)
  H.Asami, A.Motoda, M.Tsukamoto. Y.Hayakawa, H.Saigusa
- Organizer
  The 37th International Symposium on Nucleic Acids Chemistry 2010
- Place of Presentation
  横浜
- Year and Date
  2010-11-11
- Data Source
  KAKENHI-PROJECT-20350076
[Presentation] c-di-GMP Produced by E.chaffeensis Regulates Bacterial Internalization into Host Cells and Intracellular Growth2009
- Author(s)
  Y.Kumagail, M.Hyodo, Y.Hayakawa, Y.Rikihisa
- Organizer
  109th American Society for Microbiology General Meeting
- Place of Presentation
  Philadelphia
- Data Source
  KAKENHI-PROJECT-20350076
[Presentation] C-di-GMP produced by E. chaffeensis Regulates Bacterial Internalization into Host Cells and Intracellular Growth2009
- Author(s)
  Yumi Kumagai, Mamoru Hyodo, Yoshihiro Hayakawa, and Yasuko Rikihisa
- Organizer
  109th American Society for Microbiology General Meeting
- Place of Presentation
  Philadelphia(U. S. A.)
- Data Source
  KAKENHI-PROJECT-20350076
[Presentation] Synthesis and biological activity of cyclic dinucleotide diphosphorothioates
- Author(s)
  Mamoru Hyodo, Shogo Ishiyama, Hiroaki Murai, Taichi Kamegaya, Michio Ohta, Stephen Lory, and Yoshihiro Hayakawa
- Organizer
  The 41st International Symposium on Nucleic Acids Chemistry 2014
- Place of Presentation
  Kitakyushu, Japan
- Year and Date
  2014-11-05 – 2014-11-07
- Data Source
  KAKENHI-PROJECT-24350087
[Presentation] Synthesis and biological activity of cG(2'–5')oA(3'–5')p
- Author(s)
  Mamoru Hyodo, Masahito Inagaki, Hiroko Miyabe, Takashi Nakamura, Hideyoshi Harashima, and Yoshihiro Hayakawa
- Organizer
  The 41st International Symposium on Nucleic Acids Chemistry 2014
- Place of Presentation
  Kitakyushu, Japan
- Year and Date
  2014-11-05 – 2014-11-07
- Data Source
  KAKENHI-PROJECT-24350087

1. MURATA Sizuaki (50157781)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. 畑辻明 (00016049)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. SEKINE Mitsuo (40111679)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. TSUKAMOTO Masaki (10362295)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
5. 松田彰 (90157313)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 金子主税 (40013833)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 大塚栄子 (80028836)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. OHTA Michio (20111841)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
9. 沢井宏明 (70012648)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 石戸良治 (60016037)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 清水剛夫 (10025893)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 佐野充 (90144097)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. YAMADA Keiko (00402561)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. Nishimura Akiko (90609322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Hyodo Mamoru (30548186)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
16. MAKINO Keisuke (50159141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. NOYORI Ryoji (50022554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KITAMURA Masato (50169885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. MARUOKA Keiji (20135304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SUZUKI Masaaki (90093046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. YAMAMOTO Hisashi (10135311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 内多潔

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 樗木俊聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HAYAKAWA Yoshihiro 早川 芳宏

早川 芳宏 ハヤカワ ヨシヒロ

Research Projects

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Investigation on biological activity of cyclic dinucleotides and elucidation of mechanism how the activity is expressed, directing toward invention of new immunostimulantsPrincipal Investigator

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Toward development of novel medicines for bacterial infection : Search of biological functions and elucidation of mechanism on occurrence of the functions of c-di-GMP and related compoundsPrincipal Investigator

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RNA関連ゲノム研究の礎となるRNAオリゴマーの高効率合成法の開発Principal Investigator

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Creation and efficient synthesis of nucleic acids and related compounds with valuable functionality and bioactivityPrincipal Investigator

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Basic Research for the Creation of Artificial Nucleic Acids and Related Biomolecules with Useful FunctionsPrincipal Investigator

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生体関連有機リン化合物の高効率合成Principal Investigator

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有機リン酸関連化合物の経済的、実用的合成法Principal Investigator

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制限酵素機能を有する人工修飾オリゴDNAの創出Principal Investigator

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動的速度分割による光学活性分子構築法:有機リン化合物の実用的不斉合成法の開発Principal Investigator

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Enantioselective Synthesis of Unsymmetrically-Substituted Organophosphorus Compounds with Stereogenic Phosphorus AtomsPrincipal Investigator

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特異な構造をもつRNAの化学合成と反応Principal Investigator

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非イオン性インターヌクレオチド結合をもつDNAの合成と機能Principal Investigator

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核酸の構造と機能の有機化学的展開(成果とりまとめ)

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核酸の構造と機能の有機化学的展開

HAYAKAWA Yoshihiro 早川芳宏

早川芳宏ハヤカワヨシヒロ