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NISHIKAWA Takeji  西川 武二

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… Alternative Names

NISHIKAWA T.  西川 武二

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Researcher Number 50051579
Other IDs
Affiliation (based on the past Project Information) *help 1995 – 2004: Keio Univ., Sch.of Med., Professor, 医学部, 教授
2003: 慶応義塾大学, 医学部, 教授
2000: 慶応義塾大学, 医学部, 教授
1996: Keio Univ, Sch, Med., Professor, 医学部, 教授
1995 – 1996: 慶応義塾大学, 医学部・皮膚科, 教授 … More
1993 – 1996: Keio Univ.Sch.Med., Professor, 医学部・皮膚科, 教授
1993: 慶応義塾大学, 医学部・皮膚科, 教授
1990 – 1992: 慶応義塾大学, 医学部, 教授
1990 – 1992: 慶應義塾大学, 医学部, 教授
1990 – 1991: 慶應義塾大学, 医学部・皮膚科, 教授
1988: 慶應義塾大学, 医学部皮膚科, 教授
1987 – 1988: 慶応大学, 医学部・皮膚科, 教授
1986 – 1987: 慶應義塾大学, 医学部, 教授
1986: Department of Dermatology, Keio University School of Medicine, 医学部, 教授 Less
Review Section/Research Field
Principal Investigator
Dermatology
Except Principal Investigator
Dermatology / Otorhinolaryngology / Immunology / Dermatology
Keywords
Principal Investigator
天疱瘡 / デスモグレイン / 自己抗体 / 類天疱瘡 / Autoantibody / Desmoglein / Pemphigus / カドヘリン / immunoelectron microscopy / 免疫電顕 … More / Autoimmune / ノックアウトマウス / ELISA / bullous pemphigoid / desmoglein / pemphigus / Model mouse / 水疱症 / モデルマウス / 自己免疫 / cornified cell envelope / Animal model / 動物モデル / 自己免疫性皮膚疾患 / Cadherin / エピトープ / cadherin / リコンビナント蛋白 / デスモソーム / prenatal diagnosis / 19-DEJ-1 / LH7.2 / GB3 / 出生前診断 / cryosubstitution / epidermolysis bullosa / 凍結置換 / 凍結固定 / 分子生物学 / immunoblotting / 線状IgA皮膚症 / 免疫ブロット法 / 自己免疫性水疱症 / デスモゾーム / Pemphigoid / 浸潤細胞 / 細胞表面マーカー / Cytoskeleton / Adenovirus / Keratin / Cell adhesion / 細胞骨格 / アデノウイルス / ケラチン / 細胞接着 / Therapy / Immune suppression / 天庖瘡 / 治療 / 免疫抑制 / knockout mouse / bullous disease / epitope / transglutaminase 1 / non-bullous congenital ichthyosiform erthroderma / ichthyosis / genodermatosis / gene mutation / 非水疱型魚鱗癬様紅皮症 / 遺伝子異変 / ロリクリン / トランスグルタミナーゼ / セル・エンベロープ / 葉状魚鱗癬 / 非水泡型魚鱗癬様紅皮症 / 道化師様魚鱗癬 / Knochout mouse / B cell / Tolerance / Autoimmune diseases / 抗体産生B細胞 / 免疫寛容 / Gene therapy / Epidermal sheets / Type VII collagen / Laminin 5 / Inherited skin disease / 自己免疫皮膚疾患 / 遺伝子解析 / 遺伝子治療 / 表皮シート / VII型コラーゲン / ラミニン5 / 遺伝性皮膚疾患 / Recombinant Protein / Diagnostic tool / Desmosome / Autoimmune Disease / 血漿交換療法 / バキュロウィルス / 組換え蛋白 / 診断薬 / 自己免疫疾患 / crvofixation / crvoultramicrotomy / セドヘリン / クリオウルトラ切手 / クリオウルトラ切片 / 凍結同定 / 落葉状天疱瘡 / 尋常性天疱瘡 / Recombinant protein / Desmoglein, / Molecular biology, / Desmosome, / Dermatitis herpetiformis, / Bullous pemphigoid, / Pemphigus, / Autoimmune bullous disease, / 自己抗原 / 疱疹状皮膚炎 / 水疱性類天疱瘡 / electron microscopy / fetal skin biopsy / 遺伝相談 / 表皮水疱症 / 電顕 / 胎児皮膚生検 / 先天性表皮水疱症 / hemidesmosome / image analyzer / cryofixation / colloidal gold / 基底膜 / ヘミデスモゾーム / イメージアサライザー / 金コロイド / 皮膚水疱症 / antigenic epitopes for epidermal basement zone / anti-basement membrane zone antibodies / エピト-プ / 自己免疫性疾患 / リコンビナント(基底膜抗原)蛋白 / 抗表性基底膜部抗体 / 自己免疫性水疱瘡 / 表皮基底膜部抗原エピト-プ / 抗基底膜部抗体 / immunoprecipitation / autoimmune bullous diseases / hereditary and familial bullous diseases / 抗表皮基底膜部抗体 / 免疫沈降法 / 遺伝性家族性水疱症 / デスモプラキン / モノクローナル抗体 / 抗表皮細胞間抗体 / HUMURA法 / HUMARA法 / マイクロダイセクション / クローナリティー / 遺伝子多型性 / X染色体 … More
Except Principal Investigator
天疱瘡 / デスモグレイン / 自己抗体 / 自己免疫 / pemphigus / 細胞接着 / モデルマウス / カドヘリン / デスモソーム / ノックアウトマウス / B cell / desmoglein / epidermolysis bullosa / ラミニン5 / デスモヨ-キン / 自己免疫疾患 / 掌蹠膿疱症 / デスモグレイン3 / T細胞 / B細胞 / basement membrane / type VII collagen / laminin 5 / VII型コラーゲン / LAMB3 / 出生前診断 / 表皮水疱症 / Cell adhesion / 分子生物学 / 表皮 / ELISA / 遺伝子治療 / cDNA / G-CSF / model mouse / immunoelectron microscopy / BPAG2 / 免疫電顕法 / autoantibody / animal model / 免疫寛容 / knockout mouse / autoimmune disease / Self tolerance / Rag-2 / 自己寛容 / TNFA遺伝子プロモーター領域 / 尋常性天疱瘡 / HLA / Cadherin / Pemphigus / Autoimmune disease / 自己免疫性疾患 / 基底膜 / Herlitz致死型 / 劣性栄養障害型 / keratinocyte / DNA / laminin5 / prenatal diagnosis / 遺伝子診断 / Herlitz / デスモコリン / ケラチノサイト / 細胞間接着 / 水疱症 / 自己抗原 / 細胞膜 / 分子生物 / 角化細胞 / Skin fibroblasts / Elastin mRNA / エラスチン合成制御機構 / ヒトエラスチンcDNA / 皮膚線維芽細胞 / エラスチンmRNA / Anetoderma / エラスチン代謝異常症 / エラスチン遺伝子 / cell adhision / plakoglobin / desmoplakin / desmosome / pemphigus vulgaris / 電子顕微鏡 / プラコグロビン / デスモプラキン / 免疫電顕 / sterile pustule / palmoplamtar pustulosis / ペプチドグリカン / 無菌性膿疱 / 動物モデル / Staphylococcus aureus / cadherin / skin infection / autoimmune / 黄色ブドウ球菌 / 皮膚感染症 / desmoglein 3 / transgenic mouse / 単クローン抗体 / トランスジェニックマウス / tonsilar provocation test / TNFAmicrosatellite / TNFApromoter region / susceptible gene / palmoplantar pustulosis / 扁桃刺激試験 / IL-1 RA / マイクロサテライト / TNFA / 掌蹠膿庖症 / mutation analysis / 遺伝子変異 / 先天性表皮水疱症 / CD40 ligand / Skin graft / Knockout mouse / Model mouse / Autoimmune / Immune response / Inherited disease / Gene therapy / 経鼻免疫 / 経口免疫 / 遺伝性皮膚疾患 / CD40リガンド / 皮膚移植 / 免疫宣容 / 遺伝皮膚疾患 / tolerance / autoimmune diseases / モデルハウス / ELISPOT法 / T cell / 養子移入 / rag-2ノックアウトマウス / ノクアウトマウス / 天痘瘡 / Tumor necrosis factor A promotor region / Tumor necrosis factor B gene / Polymorphism / Palmoplantar pustulosis / HLA-DR / TNF遺伝子多型性 / TNF遺伝子多型 / Human Leukocyte Antigen (HLA) / Desmoglein 3 (Dsg 3) / T lymphocyte / Pemphigus vulgaris (PV) / Immunotherapy / Mutation / P-loop / Melanosomal proteins / cDNA cloning / T cells / Tumor antigens / Melanoma / gp100 / チロシナーゼ / 突然変異 / 免疫療法 / 突原変異 / P-ループ / メラノソーム蛋白 / cDNA発現クローニング / 腫瘍抗原 / メラノーマ / Dersmoglein / Disease activity / Diagnostic tool / 病勢モニタリング / 診断薬 / Desmoglein / Recombinant toxin / Disease-specific therapy / 組換え毒素 / 疾患特異的治療法 / gene transfection / epidermis / gene therapy / SV40 / 遺伝子導入 / 培養表皮シート / Vil型コラーゲン / 培養表皮 / skin disease / DNA based diagnosis / inherited diseases / COL7A1 / heteroduplex法 / 遺伝子変異部位 / Laminin 5 / 表皮水泡症 / 皮膚基底膜 / 遺伝病 / DNA診断 / envoplakin / desmoyokin / psoriasis vulgaris / intracellular signal transduction / cell adhesion / 増殖 / 炎症 / エンボプラキン / 尋常性乾癬 / 細胞内情報伝達 / lethal type / 致死型 / 尋常性天疱瘡抗原 / 遺伝子工学 / ウエスタンブロット / 複合蛋白 / Biochemistry / Molecular biology / Desmoyokin / Desmosome / Epidermis / 生化学 / デスモソ-ム / コラーゲン合成 / ヒト表皮細胞 / 培養細胞 / 血清学的検査 / 免疫抑制療法 / CD156 / CD40L / エピトープ / 重症度 / BIAcore / バイオセンサー / 反応速度 / 発現ベクター / 皮膚 / 器官培養 / 表皮細胞 / 蛋白発現 / Naked DNA injection / 神経芽細胞膜 / 皮膚疾患 / 神経芽細胞腫 / 癌抑制遺伝子 Less
  • Research Projects

    (45 results)
  • Research Products

    (27 results)
  • Co-Researchers

    (66 People)
  •  天疱瘡自己抗体の病的活性測定法の開発

    • Principal Investigator
      天谷 雅行
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Molecular basis of keratinocyte desmosomes and acantholysis using imunoelectron microscopy

    • Principal Investigator
      ISHIKO Akira
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  抗CD40Lモノクローナル抗体を用いた新しい免疫抑制療法の開発

    • Principal Investigator
      TAKAE Yujirou
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  X染色体遺伝子多型性を用いた皮膚腫瘍性疾患のクローナリティー判定法の確立Principal Investigator

    • Principal Investigator
      西川 武二
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Real-time imaging analysis of cell adhesion molecules of epidermal keratinocytesPrincipal Investigator

    • Principal Investigator
      NISHIKAWA Takeji
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Establishment of animal model for diagnosis and treatment of palmoplamtar pustulosis

    • Principal Investigator
      HASHIGUCHI Kazuhiro
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      The Kitasato Institute
  •  天疱瘡病的自己抗体の認識する3次元エピトープの解析

    • Principal Investigator
      ANZAI Hidemi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Mechanisms of B cell tolerance against peripheral antigen

    • Principal Investigator
      KOYASU Shigeo
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Keio University
  •  Clarification of pathophysiological mechanisms of autoimmune skin disease, pemphigus

    • Principal Investigator
      AMAGAI Masayuki
    • Project Period (FY)
      2001 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Basic studies for development of disease-specific therapeutic strategies against autoimmune diseasesPrincipal Investigator

    • Principal Investigator
      NISHIKAWA Takeji
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Evaluation of immune suppressive therapy using autoimmune model mousePrincipal Investigator

    • Principal Investigator
      NISHIKAWA Takeji
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Immunoelectron microscopic analysis of basement membrane components in type VII collagen knockout skin

    • Principal Investigator
      ISHIKO Akira
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Study on the susceptible gene in the TNF region in the patients with palmoplantar pustulosis

    • Principal Investigator
      HASIGUCHI Kazuhiro
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      The Kitasato Institute
  •  抗原抗体反応速度論的解析による自己抗体病原性強度の新しい指標の開発

    • Principal Investigator
      天谷 雅行
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Cellular mechanisms of tolerance breakdown in autoantibody production

    • Principal Investigator
      KOYASU Shigeo
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Keio University
  •  Study on pathophysiological mechanism of autoantibody production in pemphigus

    • Principal Investigator
      AMAGAI Masayuki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Development of immune supression against gene product in gene therapy

    • Principal Investigator
      AMAGAI Masayuki
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Development of novel therapy against bullous diseasesPrincipal Investigator

    • Principal Investigator
      NISHIKAWA Takeji
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Development of novel mouse model for autoimmune diseases using autoantigen knockout micePrincipal Investigator

    • Principal Investigator
      NISHIKAWA Takeji
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Elucidation of Pathogenetic Mechanisms of Severe Ichthyoses and Establishment of New Method for the Diagnosis and Prenatal Disease DetectionPrincipal Investigator

    • Principal Investigator
      NISHIKAWA Takeji
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Isolation of human melanoma antigens recognized bt T cells for development of immunotherapy and gene therapy

    • Principal Investigator
      KAWAKAMI Yutaka
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Development and Characterization of Desmoglein-3 Specific T cells from Japanese Patients with Pemphigus Vulgaris

    • Principal Investigator
      SAKURAI Toshiharu
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Polymorphism in the tumor necrosis factor gene in patient with Palmoplantar pustulosis

    • Principal Investigator
      HASHIGUCHI Kazuhiro
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      The Kitasato Institute
  •  Naked DNA Injectionによる表皮細胞への遺伝子導入法の開発

    • Principal Investigator
      谷川 瑛子
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Gene therapy for epidermolysis bullosa using cultured keratinocytes sheet

    • Principal Investigator
      SHIMIZU Hiroshi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Development of antigen-specific B cell elimination by recombinant toxins in autoimmune diseases

    • Principal Investigator
      AMAGAI Masayuki
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Development of disease activity monitoring assay system by ELISA using recombinant pemphigus antigens

    • Principal Investigator
      AMAGAI Masayuki
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Molecular biological study of the role of various desmosomal component proteins on inflammatory and hyperproliferating skin diseases.

    • Principal Investigator
      HASHIMOTO Takashi
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Kurume University School of Medicine
  •  Mutation detection and DNA based prenatal diagnosis in Japanese patients with epidermolysis bullosa

    • Principal Investigator
      SHIMIZU Hiroshi
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  デスモヨ-キンの角化細胞間接着における機能の解析と皮膚疾患への関与の検討

    • Principal Investigator
      橋本 隆
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Molecular basis of Japanese with Herlitz epidermolysis bullosa and Its application to the diagnosis and prenatal diagnosis

    • Principal Investigator
      SHIMIZU Hiroshi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Development of a novel diagnostic tool using recombinant pemphigus antigens with the proper native conformation.Principal Investigator

    • Principal Investigator
      NISHIKAWA Takeji
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  角化細胞間接着におけるデスモヨ-キンの機能の解析

    • Principal Investigator
      HASHIMOTO Takashi
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Basic studies for the pathogenesis and diagnosis of the autoimmune bullous diseasesPrincipal Investigator

    • Principal Investigator
      NISHIKAWA Takeji
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Keio Gijuku University School of Medicine
  •  Clarification of pathogenesis in pemphigus : Establishment of new techniques for diagnosis.Principal Investigator

    • Principal Investigator
      NISHIKAWA Takeji
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  デスモソームカドヘリン群cDNAを用いた天疱瘡抗原の解析

    • Principal Investigator
      橋本 隆
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Establishment of prenatal diagnosis of epidermolysis bullosa in JapanPrincipal Investigator

    • Principal Investigator
      NISHIKAWA Takeji
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio Gijuku University
  •  Application of up-to date immunoelectron microscopy for the study of pathogenesis of skin blistering disease.Principal Investigator

    • Principal Investigator
      NISHIKAWA Takeji
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Basic studies for the diagnosis of bullous diseases having pathologic changes at the basement membrane zonePrincipal Investigator

    • Principal Investigator
      NISHIKAWA Takeji
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Keio Gijuku University
  •  Cloning of total cDNA for desmoplakin and its molecular analysis and chromosomal mapping

    • Principal Investigator
      HASHIMOTO Takashi
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Detection of antigen epitope for bullous pemphigois antigenic protein and the development of autoantibody detection using synthetic polypeptidePrincipal Investigator

    • Principal Investigator
      NISHIKAWA Takeji
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Molecular cloning of human elastin cDNA and its application to heveditary elastin disease

    • Principal Investigator
      TAJIMA Shingo
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  培養ヒト表皮細胞によるコラーゲン合成およびその制禦機構の解明

    • Principal Investigator
      TAJIMA Shingo
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  デスモゾーム蛋白と天疱瘡の抗原物質の関連に関する研究Principal Investigator

    • Principal Investigator
      西川 武二
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Role of cutaneous infiltrates in pemphigoid and pemphigus.Principal Investigator

    • Principal Investigator
      NISHIKAWA T.
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      School of Medicine, Keio University

All 2005 2004 2003 2002 2001

All Journal Article Patent

  • [Journal Article] In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line.2005

    • Author(s)
      Shimizu A, Ishiko A, Ota T, Saito H, Oka H, Tsunoda K, Amagai M, Nishikawa T.
    • Journal Title

      J Invest Dermatol 124

      Pages: 984-989

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370262
  • [Journal Article] In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line2005

    • Author(s)
      Shimizu A, Ishiko A, Ota T, Saito H, Oka H, Tsunoda K, Amagai M, Nishikawa T
    • Journal Title

      J Invest Dermatol (In press)

    • Data Source
      KAKENHI-PROJECT-13854017
  • [Journal Article] In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line2005

    • Author(s)
      Shimizu A, Ishiko A, Ota T, Saito H, Oka H, Tsunoda K, Amagai M, Nishikawa T
    • Journal Title

      J Invest Dermatol (In press)

    • Data Source
      KAKENHI-PROJECT-14370262
  • [Journal Article] In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line.2005

    • Author(s)
      Shimizu A, Ishiko A, Ota T, Saito H, Oka H, Tsunoda K, Amagai M, Nishikawa T.
    • Journal Title

      J Invest Dermatol. 124

      Pages: 984-989

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370262
  • [Journal Article] In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line2005

    • Author(s)
      Shimizu A, Ishiko A, Ota T, Saito H, Oka H, Tsunoda K, Amagai M, Nishikawa T
    • Journal Title

      J Invest Dermatol (In press)

    • Data Source
      KAKENHI-PROJECT-15659266
  • [Journal Article] Auto-reactive B cells against peripheral antigen, desmoglein 3, escape from tolerance mechanism2004

    • Author(s)
      Ota T, Aoki-Ota M, Tsunoda K, Simoda K, Nishikawa T, Amagai M, Koyasu S
    • Journal Title

      Int Immunol 161

      Pages: 1487-1495

    • NAID

      10013567441

    • Data Source
      KAKENHI-PROJECT-13854017
  • [Journal Article] A mouse model of pemphigus vulgaris by adoptive transfer of naive splenocytes from desmoglein 3 knockout mice2004

    • Author(s)
      Aoki-Ota M, Tsunoda K, Ota T, Iwasaki T, Koyasu S, Amagai M, Nishikawa T
    • Journal Title

      Br J Dermatol 151

      Pages: 346-354

    • Data Source
      KAKENHI-PROJECT-13854017
  • [Journal Article] Conformational epitope mapping of antibodies against desmoglein 3 in experimental murine pemphigus vulgaris2004

    • Author(s)
      Anzai H, Fujii Y, Nishifuji K, Aoki-Ota M, Ota T, Amagai M, Nishikawa T.
    • Journal Title

      J Dermatol Sci 35

      Pages: 133-142

    • NAID

      10016184597

    • Data Source
      KAKENHI-PROJECT-14370262
  • [Journal Article] Auto-reactive B cells against peripheral antigen, desmoglein 3, escape from tolerance mechanism.2004

    • Author(s)
      Ota T, Aoki-Ota M, Tsunoda K, Simoda K, Nishikawa T, Amagai M, Koyasu S
    • Journal Title

      Int Immunol 16(10)

      Pages: 1487-1495

    • NAID

      10013567441

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13854017
  • [Journal Article] A mouse model of pemphigus vulgaris by adoptive transfer of naive splenocytes from desmoglein 3 knockout mice2004

    • Author(s)
      Aoki-Ota M, Tsunoda K, Ota T, Iwasaki T, Koyasu S, Amagai M, Nishikawa T
    • Journal Title

      Br J Dermatol 151

      Pages: 346-354

    • Data Source
      KAKENHI-PROJECT-14370262
  • [Journal Article] Auto-reactive B cells against peripheral antigen, desmoglein 3, escape from tolerance mechanism2004

    • Author(s)
      Ota T, Aoki-Ota M, Tsunoda K, Simoda K, Nishikawa T, Amagai M, Koyasu S
    • Journal Title

      Int Immunol 16・10

      Pages: 1487-1495

    • NAID

      10013567441

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13854017
  • [Journal Article] A mouse model of pemphigus vulgaris by adoptive transfer of naive splenocytes from desmoglein 3 knockout mice2004

    • Author(s)
      Aoki-Ota M, Tsunoda K, Ota T, Iwasaki T, Koyasu S, Amagai_M, Nishikawa T
    • Journal Title

      Br J Dermatol 151

      Pages: 346-354

    • Data Source
      KAKENHI-PROJECT-15659266
  • [Journal Article] Auto-reactive B cells against peripheral antigen, desmoglein 3, escape from tolerance mechanism2004

    • Author(s)
      Ota T, Aoki-Ota M, Tsunoda K, Simoda K, Nishikawa T, Amagai M, Koyasu S
    • Journal Title

      Int Immunol 161

      Pages: 1487-1495

    • NAID

      10013567441

    • Data Source
      KAKENHI-PROJECT-14370262
  • [Journal Article] Auto-reactive B cells against peripheral antigen, desmoglein 3, escape from tolerance mechanism2004

    • Author(s)
      Ota T, Aoki-Ota M, Tsunoda K, Simoda K, Nishikawa T, Amagai M, Koyasu S
    • Journal Title

      Int Immunol 161

      Pages: 1487-1495

    • NAID

      10013567441

    • Data Source
      KAKENHI-PROJECT-15659266
  • [Journal Article] Conformational epitope mapping of antibodies against desmoglein 3 in experimental murine pemphigus vulgaris2004

    • Author(s)
      Anzai H, Fujii Y, Nishifuji K, Aoki-Ota M, Ota T, Amagai M, Nishikawa T.
    • Journal Title

      J Dermatol Sci 35

      Pages: 133-142

    • NAID

      10016184597

    • Data Source
      KAKENHI-PROJECT-13854017
  • [Journal Article] IgG binds to desmoglein 3 in desmosomes and causes a desmosomal split without keratin retraction in a pemphigus mouse model.2004

    • Author(s)
      Shimizu A, Ishiko A, Ota T, Tsunoda K, Amagai M, Nishikawa T
    • Journal Title

      J Invest Dermatol 122

      Pages: 1145-1153

    • Data Source
      KAKENHI-PROJECT-14370262
  • [Journal Article] Auto-reactive B cells against peripheral antigen, desmoglein 3, escape from tolerance mechanism.2004

    • Author(s)
      Ota T, Aoki-Ota M, Tsunoda K, Simoda K, Nishikawa T, Amagai M, Koyasu S.
    • Journal Title

      Int Immunol 16

      Pages: 1487-1495

    • NAID

      10013567441

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370262
  • [Journal Article] IgG binds to desmoglein 3 in desmosomes and causes a desmosomal split without keratin retraction in a pemphigus mouse model.2004

    • Author(s)
      Shimizu A, Ishiko A, Ota T, Tsunoda K, Amagai M, Nishikawa T.
    • Journal Title

      J Invest Dermatol 122

      Pages: 1145-1153

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370262
  • [Journal Article] Conformational epitope mapping of antibodies against desmoglein 3 in experimental murine pemphigus vulgaris2004

    • Author(s)
      Anzai H, Fujii Y, Nishifuji K, Aoki-Ota M, Ota T, Amagai M, Nishikawa T.
    • Journal Title

      J Dermatol Sci 35

      Pages: 133-142

    • NAID

      10016184597

    • Data Source
      KAKENHI-PROJECT-15659266
  • [Journal Article] Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 32003

    • Author(s)
      Tsunoda K, Ota T, Aoki M, Yamada T, Nagai T, Nakagawa T, Koyasu S, Nishikawa T, Amagai M
    • Journal Title

      J Immunol 170・4

      Pages: 2170-2178

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13854017
  • [Journal Article] Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3.2003

    • Author(s)
      Tsunoda K, Ota T, Aoki M, Yamada T, Nagai T, Nakagawa T, Koyasu S, Nishikawa T, Amagai M
    • Journal Title

      J Immunol 170(4)

      Pages: 2170-2178

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13854017
  • [Journal Article] Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3.2003

    • Author(s)
      Tsunoda K, Ota T, Aoki M, Yamada T, Nagai T, Nakagawa T, Koyasu S, Nishikawa T, Amagai M.
    • Journal Title

      J Immunol 170

      Pages: 2170-2178

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370262
  • [Journal Article] Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris.2002

    • Author(s)
      Tsunoda K, Ota T, Suzuki H, Ohyama M, Nagai T, Nishikawa T, Amagai M, Koyasu S
    • Journal Title

      Eur J Immunol 32(3)

      Pages: 627-633

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13854017
  • [Journal Article] Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris2002

    • Author(s)
      Tsunoda K, Ota T, Suzuki H, Ohyama M, Nagai T, Nishikawa T, Amagai M, Koyasu S
    • Journal Title

      Eur J Immunol 32・3

      Pages: 627-633

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13854017
  • [Journal Article] Dominant autoimmune epitopes recognized by pemphigus antibodies map to the N-terminal adhesive region of desmogleins.2001

    • Author(s)
      Sekiguchi M, Futei Y, Fujii Y, Iwasaki T, Nishikawa T, Amagai M
    • Journal Title

      J Immunol 167(9)

      Pages: 5439-5448

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13854017
  • [Journal Article] Dominant autoimmune epitopes recognized by pemphigus antibodies map to the N-terminal adhesive region of desmogleins2001

    • Author(s)
      Sekiguchi M, Futei Y, Fujii Y, Iwasaki T, Nishikawa T, Amagai M
    • Journal Title

      J Immunol 167・9

      Pages: 5439-5448

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13854017
  • [Patent] 天疱瘡モノクローナル抗体2002

    • Inventor(s)
      角田和之, 天谷雅行, 西川武二, 小安重夫
    • Industrial Property Rights Holder
      学校法人慶應義塾
    • Filing Date
      2002-09-04
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13854017
  • 1.  AMAGAI Masayuki (90212563)
    # of Collaborated Projects: 28 results
    # of Collaborated Products: 26 results
  • 2.  HASHIMOTO Takashi (20129597)
    # of Collaborated Projects: 17 results
    # of Collaborated Products: 0 results
  • 3.  SHIMIZU Hiroshi (00146672)
    # of Collaborated Projects: 15 results
    # of Collaborated Products: 0 results
  • 4.  TANAKA Masaru (40188339)
    # of Collaborated Projects: 7 results
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  • 5.  ISHIKO Akira (10202988)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 6 results
  • 6.  KOYASU Shigeo (90153684)
    # of Collaborated Projects: 7 results
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  • 7.  SHIMIZU Nobuyoshi (50162706)
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  • 8.  SUZUKI Harimi (70235985)
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  • 9.  HASHIGUCHI Kazuhiro (80172849)
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  • 13.  谷川 瑛子 (00203117)
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