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IWASHITA Yoshiko  岩下 淑子

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Researcher Number 50111498
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Affiliation (based on the past Project Information) *help 2009 – 2010: Iwaki Meisei University, 薬学部, 客員研究員
2008: (財)東京都高齢者研究・福祉振興財団, 東京都老人総合研究所, 副参事研究員
2008: Tokyo Metropolitan Institute of Gerontology, 東京都老人総合研究所, 研究副部長
2007: (財)東京都高齢者研究・福祉振興, 東京都老人総合研究所, 副参事研究員
2007: Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare, Tokyo Metropolit, Senior Research Scientist … More
2006: 財団法人東京都高齢者研究福祉振興財団, 東京都老人総合研究所, 副参事研究員
2006: 都高齢者研究, 福祉振興財団・都老人研生体膜機能研究グループ, 副参事研究員
2006: Tokyo Metropolitan Institute of Gerontology, Biomembrane Research Group, Group leader, 福祉振興財団・都老人研・生体膜機能研究グループ, 副参事研究員
2005 – 2006: Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare, Tokyo Metropolitan Institute of Gerontology, Senior Research Scientist, 東京都老人総合研究所, 研究副部長
2005 – 2006: 東京都老人総合研究所, 生体膜機能研究グループ, 副参事研究員
2005: 高齢者研究, 福祉振興団体・都老人研生体膜機能研究グループ, 副参事研究員
2004 – 2005: 財団法人東京都高齢者研究, 福祉振興財団・東京都老人総合研究所, 副参事研究員
2004: 高齢者研究, 福祉振興財団・都老人研生体膜機能研究グループ, 副参事研究員
2003: Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare, Tokyo Metropolitan Institute of Gerontology, Biomembrane Research Group, Senior Research Scientist, 東京都老人総合研究所・生体膜機能研究グループ, 副参事研究員
2003: Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare, Tokyo Metropolitan Institute of Gerontology, Biomembrane Research Group, Senior Research Scientist, 福祉振興財団・東京都老人総合研究所・生体膜機能研究グループ, 副参事研究員
2002: (財)東京都高齢者研究, 福祉振興財団・東京都老人総合研究所・生体膜機能研究グループ, グループリーダー(研究職)
2002: (財)東京都高齢者研究・福祉振興財団, 東京都老人総合研究所・生体膜機能研究グループ, グループリーダー(研究職)
2001: (財)東京都老人総合研究所, 分子生物学系・蛋白質生化学部門, 室長
2001: (財)東京都老人総合研究所, 蛋白質生化学, 室長
2000 – 2001: (財)東京都老人総合研究所, 分子生物学研究系・蛋白質生化学部門, 室長
2000 – 2001: (財)東京都老人総合研究所, 蛋白質生化学部門, 室長
1987 – 1988: (財)東京都老人総合研究所, 生化学部, 主任研究員 Less
Review Section/Research Field
Principal Investigator
Structural biochemistry / 物質生物化学 / Functional biochemistry / Structural biochemistry / Functional biochemistry
Except Principal Investigator
Biological Sciences / Neurology / Nerve anatomy/Neuropathology / Functional biochemistry / Structural biochemistry
Keywords
Principal Investigator
コレステロール / コレステロール結合毒素 / 細胞膜 / 脂質ラフト / CHOLESTEROL / Tリンパ球 / Cholesterol / SIGNALING / LIPID RAFTS / 情報伝達 … More / ラフト / シグナル伝達 / Reductive Methylation / Limited Broteolysis / Erythrocytes / theta-Toxin / Thiol-Activated Cytolysins / Cell Membrane / θ-毒素 / 膜流動性 / 還元メチル化 / プロテアーゼ限定分解 / 赤血球 / θー毒素 / チオール活性化毒素 / Cell membrane / Signal transduction / T lymphocyte / Lipid raft / PERRINGOLYSIN O / T LYMPHOCYTES / コレストロール / JURKAT CELLS / PERFRINGOLYSIN O / MICRODOMAIN / 脂質ミクロドメイン / 脂質マイクロドメイン / T細胞 / マイクロドメイン / PLASMA MEMBRANE / PLATELET / PERFRINGOLYSINO / RAFTS / LIPID DOMAIN / β-シクロデキストリン / Perfringolysin O / 血小板 / perfringolysin O / 脂質ラフ / 膜機能ドメイン / 生体膜 … More
Except Principal Investigator
コレステロール / NMR / ラフト / 脂質ラフト / イオンチャネル / PFOタンパク質 / 立体構造 / Niemann-Pick disease / Neuron / Cholesterol / ニーマン・ピック病C型 / 神経細胞 / dementia / apolipoprotein E / cholesterol / lipid raft / amyloid β protein / Alzheimer's disease / 痴呆 / 認知症 / アポリポ蛋白E / βアミロイド / アルツハイマー病 / MICRODOMAIN / GREEN FLUORESCENT PROTEIN / VISUALIZATION / PERERINGOLYSIN O / LIPID RAFTS / FIBROBLAST / CHOLESTEROL / MDCK細胞 / 脂質ミクロドメイン / 脂質マイクロドメイン / 線維芽細胞 / 緑色蛍光蛋白質 / 繊維芽細胞 / マイクロドメイン / 可視化 / コレステロール結合毒素 / Phopsholipids / Activation mechanism / Higher order structure of protein / X ray structural analysis / Protease / Calcium / Calpain / リン脂質 / 蛋白質の構造変化 / タンパク質の高次構造 / カルシウム / 活性化機構 / 蛋白質の高次構造 / X線構造解析 / プロテアーゼ / カルパイン / リボソーム / 膜タンパク質 / PFO / デアミネーション / HIV / APOBEC3G / 残余双極子結合 / 常磁性緩和促進 / 4重鎖 / NMP / 膜 / 蛋白質 / 生物物理 / 生体分子 / 核酸 / リポソーム / 構造 / タンパク質 / 生体膜 / Perfringolysin 0 / 毒素 Less
  • Research Projects

    (13 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (14 People)
  •  STRUCTURE-FUNCTION RELATIONSHIP OF CHOLESTEROL-ENRICHED MEMBRANE MICRODOMAINSPrincipal Investigator

    • Principal Investigator
      IWASHITA Yoshiko
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Structural biochemistry
    • Research Institution
      Tokyo Metropolitan Institute of Gerontology
  •  ラフトタンパク質PFOの構造・相互作用解析と核酸性イオンチャネルの創製

    • Principal Investigator
      片平 正人
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Yokohama City University
  •  Molecular analysis of lipid rafts involved in T-cell acrivationPrincipal Investigator

    • Principal Investigator
      IWASHITA Yoshiko
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Structural biochemistry
    • Research Institution
      Tokyo Metropolitan Institute of Gerontology
  •  ラフトのコレステロールに結合するPFOタンパク質の構造遷移と相互作用様式の解明

    • Principal Investigator
      片平 正人
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Yokohama City University
  •  Study of cholesterol roles on neuronal maintenance

    • Principal Investigator
      YAMAZAKI Tsuneo
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Gunma University
  •  機能性脂質ドメイン(ラフト)におけるコレステロールとタンパク質の相互作用の解析

    • Principal Investigator
      片平 正人
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Yokohama National University
  •  Research on cerebral beta-amyloid deposition and neurodegeneration related to lipid metabolism of the plasma membrane.

    • Principal Investigator
      YAMAGUCHI Haruyasu
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Gunma University
  •  Structure and function of cholesterol-enriched membrane microdomains (lipid rafts)Principal Investigator

    • Principal Investigator
      IWASHITA Yoshiko
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare
  •  Molecular analysis of membrane microdomains (lipid rafts) with a new cholesterol-binding probePrincipal Investigator

    • Principal Investigator
      IWASHITA Yoshiko
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Structural biochemistry
    • Research Institution
      Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare
  •  Establishment of a cellular system for visualizing intracellular lipid rafts using a new cholesterol-binding probe

    • Principal Investigator
      HAYASHI Masami
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare
  •  Analysis of Activation Mechanism of Calpain on the Basis of its Tertiary Structure

    • Principal Investigator
      SUZUKI Koichi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Structural biochemistry
    • Research Institution
      Tokyo Metropolitan Institute of Gerontology
  •  Visualization and functional analysis of cholesterol-rich membrace microdomains with a new probePrincipal Investigator

    • Principal Investigator
      IWASHITA YOSHIKO
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      Tokyo Metropolitan Institute of Gerontology
  •  Study on the interaction of theta-toxin with membrane cholesterolPrincipal Investigator

    • Principal Investigator
      IWASHITA Yoshiko
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      物質生物化学
    • Research Institution
      Tokyo Metropolitan Institute of Gerontology

All 2010 2009 2008 2005 2004

All Journal Article Presentation Book

  • [Book] 生体膜の加齢変化、新老年学第3版 p.78-84(大内尉義,秋山弘子編集代表)東京2010

    • Author(s)
      岩下淑子
    • Publisher
      東京大学出版会
    • Data Source
      KAKENHI-PROJECT-20570116
  • [Book] Cholesterol-Binding Toxins Anti-cholesterol Antibodies as Structural Probes for Cholesterol Localization. Vol.51, p.597-621(Harris, J.R.ed.)(Cholesterol Binding Cholesterol Transport Proteins)(Chapter 22) Seies : Subcellular Biochemistry2010

    • Author(s)
      Ohno-Iwashita Y., Shimada, Y., Hayashi, M. Iwamoto, M., Iwashita, S., Inomata, M.
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-20570116
  • [Book] Fluorescent sterols to study cholesterol trafficking in living cells. P.1-33(Miller, L.W.ed.)(Probes Tags to Study Biomolecular Function : for Proteins, RNA, Membranes)2008

    • Author(s)
      McIntosh, A.L., Huang, H., Atshaves, B.P., Storey, S.M., Gal legos, A.M., Spencer, T.A., Bittman, R., Ohno-Iwashita, Y., Kier, A.B., Schroeder, F.
    • Publisher
      Wiley-VCH, Weinheim
    • Data Source
      KAKENHI-PROJECT-20570116
  • [Journal Article] Use of dansyl-cholestanol as a probe of cholesterol behavior in membranes of living cells.2010

    • Author(s)
      Huang, H., McIntosh, A.L., Atshaves, B.P., Ohno-Iwashita Y., Kier, A.B., Schroeder, F.
    • Journal Title

      J.Lipid Res. 51

      Pages: 1157-1172

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20570116
  • [Journal Article] 加齢に伴って増加するPD-1陽性Tリンパ球の正体は?2010

    • Author(s)
      猪股光司、嶋田有紀子、林昌美、岩下淑子
    • Journal Title

      基礎老化研究 34

      Pages: 23-27

    • NAID

      10026103948

    • Data Source
      KAKENHI-PROJECT-20570116
  • [Journal Article]2010

    • Author(s)
      岩下淑子
    • Journal Title

      新老年学(第3版)(東京大学出版会)

      Pages: 78-84

    • Data Source
      KAKENHI-PROJECT-20570116
  • [Journal Article]2010

    • Author(s)
      Ohno-Iwashita, Y., et al.
    • Journal Title

      Cholesterol Binding and Cholesterol Transport Proteins (Subcellular Biochemistry, Vol.51)(Springer)

      Pages: 597-621

    • Data Source
      KAKENHI-PROJECT-20570116
  • [Journal Article] Plasma membrane microdomains in aging and disease2010

    • Author(s)
      Ohno-Iwashita, Y., et al.
    • Journal Title

      Geriatr.Gerontol.Int.

      Volume: 10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20570116
  • [Journal Article] Plasma membrane microdomains in aging disease.2010

    • Author(s)
      岩下淑子, 嶋田有紀子, 林昌美, 猪股光司
    • Journal Title

      Geriatr.Gerontol.Int. 10(suppl.1)

    • NAID

      10027272919

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20570116
  • [Journal Article] Age-associated up-regulation of a negative co-stimulatory receptor PD-1 in mouse CD4+ T cells.2009

    • Author(s)
      Shimada Y., Hayashi M., Nagasaka, Y., Ohno-Iwashita Y, Inomata M
    • Journal Title

      Exp.Gerontol. 44

      Pages: 517-522

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20570116
  • [Journal Article] Separation of a cholesterol-enriched microdomain involved in T-cell signal transduction2005

    • Author(s)
      Shimada, Y., Inomata, M., Suzuki, H., Hayashi, M., Waheed, A.A., Ohno-Iwashita, Y.
    • Journal Title

      FEBS J. 272

      Pages: 5454-5463

    • Data Source
      KAKENHI-PROJECT-17048009
  • [Journal Article] Axon-dominant localization of cell-surface cholesterol in cultured hippocampal neurons and its disappearance in Niemann-Pick type C model cells2005

    • Author(s)
      Tashiro, Y., Yamazaki, T., Shimada, Y., Ohno- Iwashita, Y., Okamoto, K.
    • Journal Title

      Eur.J.Neurosci.20,2015-2021. 20

      Pages: 2015-2021

    • Data Source
      KAKENHI-PROJECT-17590859
  • [Journal Article] Axon-dominant localization of cell-surface cholesterol in cultured hippocampal neurons and its disappearance in Niemann-Pick type C model cells2005

    • Author(s)
      Tashiro, Y., Yamazaki, T., Shimada, Y., Ohno-Iwashita, Y., Okamoto, K.
    • Journal Title

      Eur. J. Neurosci. 20

      Pages: 2015-2021

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590859
  • [Journal Article] Role for upregulated ganglioside biosynthesis and association of Src family kinases with microdomains in retinoic acid-induced differentiation of F9 embryonal carcinoma cells2005

    • Author(s)
      Sato, T., Zakaria, A.M., Uemura, S., Ishii, A., Ohno-Iwashita, Y., Igarashi, Y., Inokuchi.JI.
    • Journal Title

      Glycobiology 15

      Pages: 687-699

    • Data Source
      KAKENHI-PROJECT-17048009
  • [Journal Article] Adhesive surface determines raft composition in platelets adhered under flow2005

    • Author(s)
      van Lier, M., Lee, F., Farndale, R.W., Gorter, G., Verhoef, S., Ohno-Iwashita, Y., Akkerman, J.W.N., Heijnen, H.F.G
    • Journal Title

      J.Thromb.Haemost 3

      Pages: 2514-2525

    • Data Source
      KAKENHI-PROJECT-17048009
  • [Journal Article] Distinct localization of lipid rafts and externalized phosphatidylserine at the surface of apoptotic cells2005

    • Author(s)
      Ishii, H., Mori, T., Shiratsuchi, A., Nakai, Y., Shimada, Y., Ohno-Iwashita, Y., Nakanishi, Y.
    • Journal Title

      Biochem.Biophys.Res.Com. 327(1)

      Pages: 94-99

    • Data Source
      KAKENHI-PROJECT-16570127
  • [Journal Article] Perfringolysin O, a cholesterol-binding cytolysin, as a probe for lipid rafts.2004

    • Author(s)
      Ohno-Iwashita Y
    • Journal Title

      Anaerobe 10・2

      Pages: 125-134

    • Data Source
      KAKENHI-PROJECT-16300110
  • [Journal Article] コレステロールを見る2004

    • Author(s)
      嶋田有紀子, 岩下淑子
    • Journal Title

      蛋白質・核酸・酵素 49(10)

      Pages: 1381-1387

    • Data Source
      KAKENHI-PROJECT-16570127
  • [Journal Article] コレステロールを見る2004

    • Author(s)
      嶋田有紀子, 岩下淑子
    • Journal Title

      蛋白質・核酸・酵素 49・10

      Pages: 1381-1387

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16570127
  • [Journal Article] Perfringolysin O, a cholesterol-binding cytolysin, as a probe for lipid rafts2004

    • Author(s)
      Y.Ohno-Iwashita 他
    • Journal Title

      Anaerobe 10

      Pages: 125-134

    • Data Source
      KAKENHI-PROJECT-16048209
  • [Journal Article] How to visualize cholesterol2004

    • Author(s)
      Shimada, Y., Iwashita, Y.
    • Journal Title

      Protein, Nucleic Acid and Enzyme 49(10)

      Pages: 1381-1387

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16570127
  • [Presentation] 加齢で増加するPD-1陽性CD4^+T細胞は刺激に対して不応答性である2009

    • Author(s)
      嶋田有紀子、林昌美、長坂安彦、岩下淑子、猪股光司
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-20570116
  • [Presentation] 老齢マウスで見いだされた抑制型補助刺激シグナル受容体(PD-1)陽性CD4^+T細胞の性質2009

    • Author(s)
      猪股光司、嶋田有紀子、林昌美、岩下淑子
    • Organizer
      第32回日本基礎老化学会大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-20570116
  • [Presentation] 老齢マウスTリンパ球に於ける抑制型補助シグナル受容体の発現亢進2008

    • Author(s)
      猪股光司、林昌美、嶋田有紀子、岩下淑子
    • Organizer
      第31回日本基礎老化学会大会
    • Place of Presentation
      松本
    • Data Source
      KAKENHI-PROJECT-20570116
  • [Presentation] Cholesterol gradient in biological membranes2008

    • Author(s)
      Murase-Tamada, K., Murate, M., Hayakawa, T., Nakamura, K., Ito, K., Shimada Y., Ohno-Iwashita Y., Kobayashi, T.
    • Organizer
      International Symposium on Molecular System Life Sciences
    • Place of Presentation
      Kobe, Japan
    • Data Source
      KAKENHI-PROJECT-20570116
  • [Presentation] 老齢マウスT細胞に於ける抑制型補助刺激シグナル受容体PD-1の発現充進とその意義2008

    • Author(s)
      猪股光司、嶋田有紀子、林昌美、岩下淑子
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-20570116
  • [Presentation] Revisiting lipid asymmetry in red blood cells2008

    • Author(s)
      Murate, M., Shimada Y., Ohno-Iwashita Y., Umeda, M., Kobayashi, T.
    • Organizer
      Flippases 2008
    • Place of Presentation
      Ascona, Switzerl
    • Data Source
      KAKENHI-PROJECT-20570116
  • [Presentation] 加齢に伴って増加するPD-1陽性CD4+T細胞の同定とその特徴2008

    • Author(s)
      嶋田有紀子、猪股光司、林昌美、岩下淑子
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-20570116
  • 1.  INOMATA Mitsushi (30142649)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 9 results
  • 2.  片平 正人 (70211844)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  IWASHITA Shintaro (90092147)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 17 results
  • 4.  YAMAZAKI Tsuneo (80200658)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 5.  SUZUKI Koichi (80011948)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  SORIMACHI Hiroyuki (10211327)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  MAEDA Tatsuya (90280627)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  NAKAMURA MEGUMI (10159072)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  HAYASHI Masami (00192279)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  YAMAGUCHI Haruyasu (00158114)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  SASAKI Atsushi (80225862)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  MORI Takashi (60239605)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  OKAMOTO Koichi (00124652)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 14.  SAITO Megumi (90132901)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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