KIWADA Hiroshi 際田弘志

Researcher Number	50120184
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2013: 徳島大学, ヘルスバイオサイエンス研究部, 非常勤講師 2012: 徳島大学, 大学院・へルスバイオサイエンス研究部, 教授 2011 – 2012: 徳島大学, ヘルスバイオサイエンス研究部, 教授 2006 – 2012: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 1999 – 2001: 徳島大学, 薬学部, 教授 1990 – 1995: 徳島大学, 薬学部, 教授
Review Section/Research Field	Principal Investigator Physical pharmacy / Biological Sciences / 医薬分子機能学 / Physical pharmacy Except Principal Investigator 応用薬理学・医療系薬学 / Physical pharmacy / Physical pharmacy / Medical pharmacy
Keywords	Principal Investigator リポソーム / DDS / cetylmannoside / vaccine / Adjuvant / Liposomes / マンノース / FCA / セチルマンノシド / ワクチン … More / アジュバント / Pharmacokinetics / Complement receptor / Opsonin / Lysosome / Macrophage / Liposome / Drug delivery system / 補体 / クリアランス / 細胞内運命 / リポソ-ム / 薬物速度論 / 補体レセプター / オプソニン / ライソゾーム / マクロファージ / 薬物送達システム / PEG / 免疫活性化 / Anti-PEG IgM / ABC現象 / ＰＥＧ / ＤＤＳ / 免疫反応 / ポリエチレングリコール / ナノトキシコロジー / B細胞 / 抗PEG-IgM / 免疫系 / ナノキャリア / メトロノミック・ケモセラピー / 腫瘍内微小環境 / 抗がん剤 / がん治療 / 体内動態制御 / モデル動物 / 新生血管 / がん … More Except Principal Investigator リポソーム / Glial-Derived Neurotrophic Factor / がん治療 / DDS / Blood-brain barrier / Brain capillary endothelial cells / Parkinson' disease / HVJ-liposomes / Gene Therapy / 遺伝子の発現 / in vivo / in vitro / 血液脳関門 / 脳毛細血管内皮細胞 / パーキンソン病 / 膜融合リポソーム / 遺伝子治療 / aminophrine clearance / radical scavenger / hepatic function / hepatitis / free radical / hydradine derivatives / metabolic fate / ascorbic acid / 病理組織検査 / アスコルビン酸 / アミノピリン / 肝機能評価 / 肝障害 / ESR / フリーラジカル / 体内動態 / アスコルビル酸 / ヒドラジン遊離薬物 / Diameter / Saturation / Complement receptor / Opsonin / Liposomes / Pharmacokinetics / Drug delivery system / 粒子径 / 飽和性 / 補体レセプター / オプソニン / 薬物速度論 / 薬物送達システム / がん微小環境 / ドラッグデリバリー / 免疫反応 / ポリエチレングリコール / 抗原デリバリー / PEG / アジュバント / ワクチン / 代謝学 / 薬物動態 / 抗がく剤 / メトロノミック・ケモセラピー / 腫瘍内微小環境 / 抗がん剤 / EPR効果 / 腫瘍 / ナノキャリア Less

Improvement of tumor-targeting therapy with nanocarrier system by changing the tumor microenvironment.
- Principal Investigator
  
  ISHIDA Tatsuhiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokushima
Anti-PEG Immunity upon nucleic acid deliveryPrincipal Investigator
- Principal Investigator
  
  KIWADA Hiroshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokushima
Development of novel vaccine system with nanocarrier
- Principal Investigator
  
  ISHIDA Tatsuhiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokushima
Evaluation on EPR effect and active control of EPR effect for achieving efficient tumor accumulation of nanocarrier delivery system
- Principal Investigator
  
  ISHIDA Tatsuhiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokushima
腫瘍内微小環境変化を利用した新規DDSの開発Principal Investigator
- Principal Investigator
  
  際田弘志
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Study for Interaction of Biological Milieu with Nano-drug Carrier systemPrincipal Investigator
- Principal Investigator
  
  KIWADA Hiroshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokushima
がん新生血管を標的とした機能性リポソームによる革新的治療法の開発Principal Investigator
- Principal Investigator
  
  際田弘志
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Research for development of nobel type vaccine with cetylmanoside-modified liposomesPrincipal Investigator
- Principal Investigator
  
  KIWADA Hiroshi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokushima
Introduction of tyrosine hydroxylase gene into the cells from brain for the treatment of parkinson's disease.
- Principal Investigator
  
  KOYABU Noriko, 松尾浩民
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  KYUSHU UNIVERSITY
Uptake mechanism and intracellular destiny of liposomes in RES
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokushima, Faculty of Pharmaceutical Sciences
Effects of Ascorbic Acid on the Metabolic Fate and the Hepatitis of Hydrazine Derivatives
- Principal Investigator
  
  MATSUKI Yoko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  University of Tokushima
Development of intracellular drug delivery system utilizing liposomesPrincipal Investigator
- Principal Investigator
  
  KIWADA Hiroshi
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Tokushima

All 2014 2013 2012 2011 2010 2009 2008

All Journal Article Presentation Book

[Book] Cationic liposomes and tumour vasculature targeting : a therapeutic approach that has potential for solid tumours2011
- Author(s)
  Abu Lila A. S., Ishida T., Kiwada, H.
- Publisher
  i-Smithers-Creative Publishing Solutions
- Data Source
  KAKENHI-PROJECT-21689002
[Book] Breaking the barriers to tumor-targeting via nanocarrier-based drug delivery to the tumor microenvironment2010
- Author(s)
  Doi, Y., Ishida, T., Kiwada, H.
- Publisher
  Nova Science Publishers
- Data Source
  KAKENHI-PROJECT-21689002
[Book] Unexpected reactions by in vivo application of PEGylated liposomes. "(Safety of Nanoparticles : From Manufacturing to Clinical Applications (A volume in the Nanostructure Science and Technology series))(T.J.Webster (Ed.)), Chapter 6, p111-1302009
- Author(s)
  Ishida, T., Kiwada, H.
- Publisher
  Springer Science + Business Media, New York, USA
- Data Source
  KAKENHI-PROJECT-20390013
[Journal Article] B cell-intrinsic toll-like receptor 7 is responsible for the enhanced anti-PEG IgM production following injection of siRNA-containing PEGylated lipoplex in mice2014
- Author(s)
  Hashimoto, Y., Abu Lila A., Shimizu, T., Ishida, T., Kiwada, H
- Journal Title
  
  J. Control. Release
  
  Volume: 184C Pages: 1-8
- DOI
  10.1016/j.jconrel.2014.04.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390012
[Journal Article] Influence of dose and animal species on accelerated blood clearance of PEGylated liposomal doxorubicin.2014
- Author(s)
  Suzuki, T., Ichihara, M., Hyodo, K., Yamamoto, E., Ishida, T., Kiwada, H., Kikuchi, H., Ishihara, H.
- Journal Title
  
  Int. J. Pharm
  
  Volume: 476 Issue: 1-2 Pages: 205-212
- DOI
  10.1016/j.ijpharm.2014.09.047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390010
[Journal Article] Sequential treatment of oxaliplatin-containing PEGylated liposome together with S-1 improves intratumor distribution of subsequent doses of oxaliplatin-containing PEGylated liposome.2014
- Author(s)
  Nakamura, H., Doi, Y., Abu Lila, A.S., Nagao, A., Ishida, T., Kiwada, H
- Journal Title
  
  Eur. J. Pharm. Biopharm.
  
  Volume: 87 Issue: 1 Pages: 142-151
- DOI
  10.1016/j.ejpb.2013.12.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390010
[Journal Article] Generation, characterization and in vivo biological activity of two distinct monoclonal anti-PEG IgMs2014
- Author(s)
  Hashimoto Y., Shimizu T., Mima Y., Abu Lila A., Ishida T., Kiwada H
- Journal Title
  
  Toxicol. Appl. Pharmacol
  
  Volume: 277 Issue: 1 Pages: 30-38
- DOI
  10.1016/j.taap.2014.03.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390012
[Journal Article] Application of polyglycerol-coating to pDNA lipoplex for the evasion of the accelerated blood clearance (ABC) phenomenon in nucleic acid delivery2014
- Author(s)
  Abu Lila, A.S., Uehara, Y., Ishida, T., Kiwada, H
- Journal Title
  
  J. Pharm. Sci
  
  Volume: 103 Issue: 2 Pages: 557-566
- DOI
  10.1002/jps.23823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390012
[Journal Article] The co-delivery of oxaliplatin abrogates the immunogenic response to PEGylated siRNA-lipoplex2013
- Author(s)
  Alaaeldin, E.,, Abu Lila, A.S., Moriyoshi, N., Sarahan, H.A., Ishida, T., Khaled A. Khale, Kiwada, H
- Journal Title
  
  Pharm. Res
  
  Volume: 30 Issue: 9 Pages: 2344-2354
- DOI
  10.1007/s11095-013-1078-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390012
[Journal Article] The accelerated blood clearance (ABC) phenomenon: Clinical challenge and approaches to manage.2013
- Author(s)
  Abu Lila, A.S., Kiwada, H., Ishida, T.
- Journal Title
  
  J. Control. Release
  
  Volume: 172 Issue: 1 Pages: 38-47
- DOI
  10.1016/j.jconrel.2013.07.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390012
[Journal Article] Ex-vivo/in-vitro anti-polyethylene Glycol (PEG) IgM production from murine splenic B cells stimulated by PEGylated liposome.2013
- Author(s)
  Abu Lila, A.S., Ichihara, M., Shimizu, T., Ishida, T., Kiwada, H.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 36 Pages: 1842-1848
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390012
[Journal Article] Abrogation of the accelerated blood clearance phenomenon by SOXL regimen : Promise for clinical application2013
- Author(s)
  Nagao, A., Abu Lila, A.S., Ishida, T, Kiwada, H
- Journal Title
  
  Int. J. Pharm
  
  Volume: 441 Issue: 1-2 Pages: 395-401
- DOI
  10.1016/j.ijpharm.2012.11.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390012
[Journal Article] Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration.2013
- Author(s)
  Abu Lila, A.S., Nawata, K., Shimizu, T., Ishida, T., Kiwada, H.
- Journal Title
  
  Int. J. Pharm.
  
  Volume: 456 Issue: 1 Pages: 235-242
- DOI
  10.1016/j.ijpharm.2013.07.059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390012
[Journal Article] Transport of PEGylated liposomes from the splenic marginal zone to the follicle in the induction phase of the accelerated blood clearance phenomenon.2013
- Author(s)
  Shimizu T
- Journal Title
  
  Immunobiol.
  
  Volume: 218 Issue: 5 Pages: 725-732
- DOI
  10.1016/j.imbio.2012.08.274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390012, KAKENHI-PROJECT-23659082
[Journal Article] Combination therapy with metronomic S-1 dosing and oxaliplatin-containing PEG-coated cationic liposomes in a murine colorectal tumor model : Synergy or antagonism?2012
- Author(s)
  Abu Lila, A. S., Okada, T., Doi, Y., Ichihara, M., Ishida, T., Kiwada, H.
- Journal Title
  
  Int. J. Pharm.
  
  Volume: 426 Pages: 263-270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689002
[Journal Article] Accelerated blood clearance of PEGylated liposomes containing doxorubicin upon repeated administration to dogs2012
- Author(s)
  Suzuki, T., Ichihara, M., Hyodo, K., Yamamoto, E., Ishida, T., Kiwada, H., Ishihara, H., Kikuchi, H
- Journal Title
  
  Int. J. Pharm
  
  Volume: 436 Issue: 1-2 Pages: 636-643
- DOI
  10.1016/j.ijpharm.2012.07.049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390012
[Journal Article] Improved intratumoral delivery of PEG-coated siRNA-lipoplexes by combination with metronomic S-1 dosing in a murine solid tumor model2012
- Author(s)
  Tagami, T., Abu Lila, A. S., Matsunaga, M., Moriyoshi, N., Nakamura, H., Nakamura, K., Suzuki, T., Doi, Y., Ishida, T., Kiwada, H.
- Journal Title
  
  Drug Deliv. Transl. Res.
  
  Volume: 2 Pages: 77-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689002
[Journal Article] Anti-PEG IgM production by siRNA encapsulated in a PEGylated lipid nanocarrier is dependent on the sequence of the siRNA.2011
- Author(s)
  Tagami T., Uehara Y., Moriyoshi N., Ishida T., Kiwada H.
- Journal Title
  
  J.Control.Release in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390013
[Journal Article] A double-modulation strategy in cancer treatment with a chemotherapeutic agent and siRNA2011
- Author(s)
  Nakamura, K, Abu Lila A., Matsunaga, M., Doi, Y., Ishida, T., Kiwada, H.
- Journal Title
  
  Mol. Ther.
  
  Volume: 19 Pages: 2040-2047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689002
[Journal Article] Anti-PEG IgM response against PEGylated liposomes in mice and rats.2011
- Author(s)
  Ichihara M., Shimizu T., Imoto A., Hashiguchi Y., Uehara Y., Ishida T, Kiwada H.
- Journal Title
  
  Pharmaceutics in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390013
[Journal Article] Anti-PEG IgM production by siRNA encapsulated in a PEGylated lipid nanocarrier is dependent on the sequence of the siRNA2011
- Author(s)
  Tagami T., Uehara Y., Moriyoshi N., Ishida T., Kiwada H
- Journal Title
  
  J. Control. Release
  
  Volume: 151 Issue: 2 Pages: 149-154
- DOI
  10.1016/j.jconrel.2010.12.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390012
[Journal Article] Combination therapy of metronomic S-1 dosing with oxaliplatin-containing PEG-coated liposome improves antitumor activity in a murine colorectal tumor model2010
- Author(s)
  Doi Y., Okada T., Matsumoto H., Ichihara M., Ishida T., Kiwada, H.
- Journal Title
  
  Cancer Sci.
  
  Volume: 101 Pages: 2470-2475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689002
[Journal Article] T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes.2010
- Author(s)
  Koide H., Asai, T., Hatanaka, K., Akai, S., Ishii, T., Kenjo, E., Ishida, T., Kiwada, H., Tsukada, H., Oku, N.
- Journal Title
  
  Int.J.Pharm. 392
  
  Pages: 218-223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390013
[Journal Article] Optimized PEGylated adenovirus vector reduces the anti-vector humoral immune response against adenovirus and induces a therapeutic effect against metastatic lung cancer.2010
- Author(s)
  Eto Y., Yoshioka Y., Ishida T., Yao X., Morishige T., Narimatsu S., Mizuguchi H., Mukai Y., Okada N., Kiwada H., Nakagawa S.
- Journal Title
  
  Biol.Pharm.Bull. 25
  
  Pages: 149-154
- NAID
  130000322353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390013
[Journal Article] Targeting anticancer drugs to tumor vasculature using cationic liposomes2010
- Author(s)
  Abu Lila, A., Ishida, T., Kiwada, H.
- Journal Title
  
  Pharm. Res.
  
  Volume: 27 Pages: 1171-1183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689002
[Journal Article] Sequential administration with oxaliplatin-containing PEG-coated cationic liposomes promotes a significant delivery of subsequent dose into murine solid tumor2010
- Author(s)
  Abu Lila, A., Doi, Y., Nakamura, K., Ishida, T., Kiwada, H.
- Journal Title
  
  J. Control. Release
  
  Volume: 142 Pages: 167-173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689002
[Journal Article] Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers.2010
- Author(s)
  Ishihara T., Maeda T., Sakamoto H., Takasaki N., Shigyo M., Ishida T., Kiwada H., Mizushima Y., Mizushima T.
- Journal Title
  
  Biomacromolecules 11
  
  Pages: 2700-2706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390013
[Journal Article] CpG motifs in pDNA-sequences increase anti-PEG IgM production induced by PEG-coated pDNA-lipoplexes.2010
- Author(s)
  Tagami, T., Nakamura, K., Shimizu, T., Yamazaki, N., Ishida, T., Kiwada, H.
- Journal Title
  
  J.Control.Release 142
  
  Pages: 160-166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390013
[Journal Article] Recent advances in tumor vasculature targeting using liposomal drug delivery systems2009
- Author(s)
  Abu Lila, A., Ishida, T., Kiwada, H.
- Journal Title
  
  Expert Opin. Drug Deliv.
  
  Volume: 6 Pages: 1297-1309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689002
[Journal Article] Oxaliplatin encapsulated in PEG-coated cationic liposomes induces significant tumor growth suppression via a dual-targeting approach in a murine solid tumor model2009
- Author(s)
  Abu Lila, A., Kizuki, S., Doi, Y., Suzuki, T., Ishida, T., Kiwada, H.
- Journal Title
  
  J. Control. Release
  
  Volume: 137 Pages: 8-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689002
[Journal Article] Oxaliplatin targeting to angiogenic vessels by PEGylated cationic liposomes suppresses the angiogenesis in a dorsal air sac mouse model2009
- Author(s)
  Abu-Lila, A, Suzuki, T., Doi, Y., Ishida, T., Kiwada, H.
- Journal Title
  
  J. Control. Release
  
  Volume: 134 Pages: 18-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689002
[Journal Article] Accelerated blood clearance phenomenon upon repeated injection of PEG-modified PLA-nanoparticles.2009
- Author(s)
  Ishihara, T., Takeda, M., Sakamoto, H., Kimoto, A., Kobayashi, C., Takasaki, N., Yuki, K., Tanaka, K., Takenaga, M., Igarashi, R., Maeda, T., Yamakawa, N., Okamoto, Y., Otsuka, M., Ishida, T., Kiwada, H.
- Journal Title
  
  Pharm.Res. 26
  
  Pages: 2270-2279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390013
[Journal Article] Effect of siRNA in PEG-coated siRNA-lipoplex on anti-PEG IgM production.2009
- Author(s)
  Tagami, T., Nakamura, K., Shimizu, T., Ishida, T., Kiwada, H.
- Journal Title
  
  J.Control.Release 137
  
  Pages: 234-240
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390013
[Journal Article] Synergistic antitumor activity of metronomic dosing of cyclophosphamide in combination with doxorubicin-containing PEGylated liposomes in a murine solid tumor model2009
- Author(s)
  Ishida, T., Shiraga, E., Kiwada, H.
- Journal Title
  
  J. Control. Release
  
  Volume: 134 Pages: 194-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689002
[Journal Article] Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes.2008
- Author(s)
  Ishida, T., Kiwada, H.
- Journal Title
  
  Int.J.Pharm. 354
  
  Pages: 56-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390013
[Journal Article] Particle size-dependent triggering of accelerated blood clearance phenomenon.2008
- Author(s)
  Koide H., Asai, T., Hatanaka, K., Urakami, T., Ishii, T., Kenjo, E., Nishihara, M., Yokoyama, M., Ishida, T., Kiwada, H., Oku, N.
- Journal Title
  
  Int.J.Pharm. 362
  
  Pages: 197-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390013
[Journal Article] The contribution of phagocytic activity of liver macrophages to the accelerated blood clearance (ABC) phenomenon of PEGylated liposomes in rats.2008
- Author(s)
  Ishida, T., Kashima, S., Kiwada, H.
- Journal Title
  
  J.Control.Release 126
  
  Pages: 162-165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390013
[Presentation] 転移性肝臓がんの存在がオキサリプラチン封入PEG修飾リポソームの肝移行性へ与える影響2014
- Author(s)
  藤原由佳子、中村浩之、石田竜弘、際田弘志
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学（熊本県）
- Data Source
  KAKENHI-PROJECT-24390010
[Presentation] リポソームからのPemetrexedの放出性が胸腔内移植腫瘍の増殖に与える影響2014
- Author(s)
  小林早紀子、Amr Abu-Lila、石田竜弘、際田弘志
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学（熊本県）
- Data Source
  KAKENHI-PROJECT-24390010
[Presentation] In vivo imaging systemによる胸腔内投与リポプレックスの動態評価2014
- Author(s)
  加藤千尋、石田竜弘、際田弘志
- Organizer
  日本薬剤学会第２９年会
- Place of Presentation
  大宮ソニックシティビル（埼玉県さいたま市）
- Year and Date
  2014-05-20
- Data Source
  KAKENHI-PROJECT-24390010
[Presentation] 脾臓辺縁帯B細胞による抗原封入PEG修飾リポソームの濾胞への輸送現象を利用した抗腫瘍免疫誘導効果2014
- Author(s)
  清水太郎、渡辺優希、美馬優、石田竜弘、際田弘志
- Organizer
  日本薬剤学会第２９年会
- Place of Presentation
  大宮ソニックシティビル（埼玉県さいたま市）
- Year and Date
  2014-05-20
- Data Source
  KAKENHI-PROJECT-24390010
[Presentation] マウス肺癌細胞に対するFTY720とドキシルとの併用効果に関する検討2014
- Author(s)
  清水太郎、高橋孝典、石田竜弘、際田弘志
- Organizer
  第３０回日本DDS学会学術集会
- Place of Presentation
  慶應義塾大学薬学部（東京都港区）
- Year and Date
  2014-07-30
- Data Source
  KAKENHI-PROJECT-24390010
[Presentation] In vivo imaging systemによる胸腔内投与リポプレックスの動態評価2014
- Author(s)
  加藤千尋、石田竜弘、際田弘志
- Organizer
  第３０回日本DDS学会学術集会
- Place of Presentation
  慶應義塾大学薬学部（東京都港区）
- Year and Date
  2014-07-30
- Data Source
  KAKENHI-PROJECT-24390010
[Presentation] 高用量PEG修飾リポソームを用いたABC現象の回避2013
- Author(s)
  美馬優、橋本洋祐、清水太郎、石田竜弘、際田弘志
- Organizer
  第29回日本DDS学会学術集会
- Place of Presentation
  京都テルサ（京都府）
- Data Source
  KAKENHI-PROJECT-23390012
[Presentation] 脾臓辺縁体B細胞によるPEG修飾リポソームの濾胞への輸送現象を利用した特異的抗体誘導効果2013
- Author(s)
  清水太郎、渡辺優希、美馬優、橋本洋祐、石田竜弘、際田弘志
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  愛知県産業労働センター　ウインクあいち（愛知県）
- Data Source
  KAKENHI-PROJECT-23390012
[Presentation] Accelerated blood clearance phenomenon upon PEGylated protein.2013
- Author(s)
  Mima, Y., Hashimoto, Y., Shimizu, T., Ishida, T., Kiwada, H.,
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Hawaii Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-23390012
[Presentation] 抗がん剤による腫瘍内微小環境変化を利用した新規DDSの開発2013
- Author(s)
  石田竜弘、際田弘志
- Organizer
  第29回日本DDS学会学術集会
- Place of Presentation
  京都テルサ（京都府）
- Invited
- Data Source
  KAKENHI-PROJECT-23390012
[Presentation] Potentiation of specific antibody response against antigen encapsulated in PEGylated liposomes via active transport of the liposomes from marginal zone into follicle.2013
- Author(s)
  Shimizu, T., Ishida, T., Kiwada, H.
- Organizer
  5th Asian Arden Conference
- Place of Presentation
  愛知学院大学（愛知県）
- Data Source
  KAKENHI-PROJECT-24390010
[Presentation] 固形がんにおける抗がん剤封入PEG修飾リポソームとshRNA含有lipoplexによるがん治療法の確立2013
- Author(s)
  田中真生、中村浩之、森吉直人、石田竜弘、際田弘志
- Organizer
  第５２回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  松山大学（愛媛県）
- Data Source
  KAKENHI-PROJECT-24390010
[Presentation] PEG修飾剤末端構造が与えるABC現象誘導への影響に関する検討2013
- Author(s)
  藤田理紗子、橋本洋佑、清水太郎、石田竜弘、際田弘志
- Organizer
  第22回DDSカンファランス
- Place of Presentation
  グランシップ静岡（静岡県）
- Data Source
  KAKENHI-PROJECT-24390010
[Presentation] 腫瘍内血管系の動的変化がPEG修飾リポソームの腫瘍内分布に及ぼす影響2013
- Author(s)
  西尾美穂、中村浩之、石田竜弘、際田弘志
- Organizer
  第22回DDSカンファランス
- Place of Presentation
  グランシップ静岡（静岡県）
- Data Source
  KAKENHI-PROJECT-24390010
[Presentation] Transport of PEGylated liposomes to follicle induced by pre-stimulation of empty liposomes: Potentiating specific antibody responses against antigen encapsulated in the liposomes.2013
- Author(s)
  Shimizu, T., Ishida, T., Kiwada, H.
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Hawaii Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-23390012
[Presentation] 高用量PEG修飾リポソームによる抗PEG IgMの分泌抑制に関する検討2013
- Author(s)
  美馬優、橋本洋佑、清水太郎、石田竜弘、際田弘志
- Organizer
  第22回DDSカンファランス
- Place of Presentation
  グランシップ静岡（静岡県）
- Data Source
  KAKENHI-PROJECT-23390012
[Presentation] siRNA搭載PEG修飾リポプレックス投与時に誘起される抗PEG IgM分泌亢進機構の解明2013
- Author(s)
  橋本洋佑、石田竜弘、際田弘志
- Organizer
  第３５回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  東京大学（東京都）
- Data Source
  KAKENHI-PROJECT-23390012
[Presentation] Serum anti-PEG IgM concentration is a determinant factor on hepatic accumulation of PEGylated liposome in the accelerated blood clearance phenomenon.2013
- Author(s)
  Hashimoto, Y., Shimizu, T., Ishida, T., Kiwada, H.,
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Hawaii Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-23390012
[Presentation] In vivo imaging systemを用いたリポソーム胸腔内投与後の体内動態の評価2013
- Author(s)
  加藤千尋、Amr Abu-Lila、石田竜弘、際田弘志
- Organizer
  第５２回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  松山大学（愛媛県）
- Data Source
  KAKENHI-PROJECT-24390010
[Presentation] siRNA搭載PEG修飾リポプレックス投与時に惹起される抗PEG IgM分泌応答機構の解明2013
- Author(s)
  橋本洋祐、清水太郎、石田竜弘、際田弘志
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  愛知県産業労働センター　ウインクあいち（愛知県）
- Data Source
  KAKENHI-PROJECT-23390012
[Presentation] 抗がん剤による腫瘍内微小環境変化を利用した新規DDSの開発2013
- Author(s)
  石田竜弘, 際田弘志
- Organizer
  第29回日本DDS学会学術集会
- Place of Presentation
  京都テルサ(京都府京都市)
- Year and Date
  2013-07-04
- Data Source
  KAKENHI-PROJECT-23390012
[Presentation] Biological responses against lipid membrane containing PEG2011
- Author(s)
  Ishida, T., Kiwada, H
- Organizer
  3rd International Symposium on Surface and Interface of Biomaterials (SIB2011)
- Place of Presentation
  北海道大学学術交流会館(北海道札幌市)
- Year and Date
  2011-07-14
- Data Source
  KAKENHI-PROJECT-23390012
[Presentation] PEG on nanocarriers induces anti PEG IgM production as a result of activation of immune system., Nano in Cancer : Linking Chemistry2011
- Author(s)
  Hashiguchi Y., Shimizu T., Ichihara M., Ishida T., Kiwada H.
- Organizer
  Biology and Clinical Applications in vivo
- Place of Presentation
  Miami USA, Jan.
- Data Source
  KAKENHI-PROJECT-20390013
[Presentation] Improvement of tumor-targeting therapy with nanocarrier system by changing the tumor microenviroment2011
- Author(s)
  Ishida, T., Kiwada, H.
- Organizer
  2011 RCAA International Symposium Endogenous Ligands Modulating Anticancer Agents
- Place of Presentation
  Seoul, Korea
- Year and Date
  2011-02-11
- Data Source
  KAKENHI-PROJECT-21689002
[Presentation] PEG修飾ナノキャリア生体内投与後に生ずる免疫活性化(ABC現象)機構解明に関する検討2010
- Author(s)
  市原理子、石田竜弘、際田弘志
- Organizer
  第19回DDSカンファランス
- Place of Presentation
  (静岡)
- Year and Date
  2010-09-04
- Data Source
  KAKENHI-PROJECT-20390013
[Presentation] Sequential treatment, pre-dose with empty PEGylated liposome (SL) and second dose antigen-encapsulating SL, promotes activation in a primary immune response.2010
- Author(s)
  Hashiguchi, Y., Shimizu, T., Ishida T., Kiwada H.
- Organizer
  International Liposome Research Days & Lipids, Liposomes & Membrane Biophysics
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-20390013
[Presentation] Immunostimulatory properties of liposomes containing PEG.2010
- Author(s)
  Ishida, T., Kiwada, H.
- Organizer
  International Liposome Research Days & Lipids, Liposomes & Membrane Biophysics
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2010-08-06
- Data Source
  KAKENHI-PROJECT-20390013
[Presentation] 腫瘍内微小環境変化を利用したsiRNAデリバリーシステムの開発2010
- Author(s)
  石田竜弘、際田弘志
- Organizer
  第32回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  富山
- Year and Date
  2010-11-29
- Data Source
  KAKENHI-PROJECT-21689002
[Presentation] Spleen cells secret anti-PEG IgM following intravenous injection of PEGylated liposome.2010
- Author(s)
  Ichihara, M., Imoto, A., Hashiguchi, Y., Uehara, Y., Ishida T., Kiwada H.
- Organizer
  International Liposome Research Days & Lipids, Liposomes & Membrane Biophysics
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-20390013
[Presentation] 核酸デリバリーにおけるABC現象、遺伝子・デリバリー研究会2010
- Author(s)
  石田竜弘、際田弘志
- Organizer
  第10回シンポジウム
- Place of Presentation
  (札幌)
- Year and Date
  2010-06-03
- Data Source
  KAKENHI-PROJECT-20390013
[Presentation] Argonaute2標的siRNAリポプレックスを用いたがん治療戦略、学術シンポジウム4 RNAi医薬の展望. From Bench to Bedside-2009
- Author(s)
  石田竜弘、浅井知浩、奥直人、際田弘志
- Organizer
  日本薬剤学会第24年会
- Place of Presentation
  静岡
- Year and Date
  2009-05-23
- Data Source
  KAKENHI-PROJECT-21689002
[Presentation] Elucidation of ABC phenomenon caused by repeat injection of PEGylated nanocarrier.2009
- Author(s)
  Koide, H., Asai, T., Yokoyama, M., Ishida T., Kiwada H., Oku, N.
- Organizer
  4th International Liposome Society Conference. Liposome advances : Progress in Drug and Vaccine Delivery
- Place of Presentation
  London, UK
- Year and Date
  2009-12-14
- Data Source
  KAKENHI-PROJECT-20390013
[Presentation] 核酸デリバリーにおけるaccelerated blood clearance (ABC)現象2009
- Author(s)
  石田竜弘、際田弘志
- Organizer
  第25回日本DDS学会
- Place of Presentation
  (東京)
- Year and Date
  2009-07-03
- Data Source
  KAKENHI-PROJECT-20390013
[Presentation] Improvement of tumor-targeting therapy with nanocarriers by changing the tumor microenvironment2009
- Author(s)
  Ishida, T., Kiwada, H.
- Organizer
  2009 International Symposium of the Intelligent Drug Delivery System.
- Place of Presentation
  Korea
- Year and Date
  2009-04-30
- Data Source
  KAKENHI-PROJECT-21689002
[Presentation] Interaction of PEGylated liposomes with splenic marginal zone B cells may trigger production of anti-PEG IgM in the ABC phenomenon.2008
- Author(s)
  Shimizu, T., Ishida T., Kiwada H.
- Organizer
  11^<th> Liposome Research Days conference
- Place of Presentation
  Yokohama (Japan)
- Data Source
  KAKENHI-PROJECT-20390013
[Presentation] Unexpected immunological response against sterically stabilized, PEGylated, liposome after intravenous injection.2008
- Author(s)
  石田竜弘, 際田弘志
- Organizer
  International Symposium on "Nanotoxicology Assessment and Biomedical, Environmental Application of Fine Particles and Nanotubes" ISNT2008
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-20390013
[Presentation] Accelerated blood clearance (ABC) phenomenon on PEGylated nanocarrier : Unexpected immune-reaction against PEGylated liposome.2008
- Author(s)
  Shimizu, T., Ishida T., Kiwada H.
- Organizer
  International Symposium on "Nanotoxicology Assessment and Biomedical, Environmental Application of Fine Particles and Nanotubes" (ISNT2008)
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-20390013
[Presentation] Effect of siRNA on anti-PEG IgM production in the accelerated blood clearance (ABC) phenomenon when formulated with PEGylated cationic liposome.2008
- Author(s)
  Tagami, T., Nakamura, K., Shimizu, T., Ishida T., Kiwada H.
- Organizer
  11^<th> Liposome Research Days conference
- Place of Presentation
  Yokohama (Japan)
- Data Source
  KAKENHI-PROJECT-20390013

1. ISHIDA Tatsuhiro (50325271)

# of Collaborated Projects: 7 results

# of Collaborated Products: 74 results
2. HARASHIMA Hideyoshi (00183567)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. KOYABU Noriko (00315102)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SUGIYAMA Yuichi (80090471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MATSUKI Yoko (20035546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. OHTANI Hisakazu (70262029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SAWADA Yasufumni (80114502)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 佐塚泰之 (90162403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 山崎尚志 (20271083)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 松尾浩民 (60274479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KIKUCHI Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 菊地寛

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KIWADA Hiroshi 際田 弘志

Research Projects

Research Products

Co-Researchers

Improvement of tumor-targeting therapy with nanocarrier system by changing the tumor microenvironment.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Anti-PEG Immunity upon nucleic acid deliveryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel vaccine system with nanocarrier

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation on EPR effect and active control of EPR effect for achieving efficient tumor accumulation of nanocarrier delivery system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

腫瘍内微小環境変化を利用した新規DDSの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study for Interaction of Biological Milieu with Nano-drug Carrier systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

がん新生血管を標的とした機能性リポソームによる革新的治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research for development of nobel type vaccine with cetylmanoside-modified liposomesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Introduction of tyrosine hydroxylase gene into the cells from brain for the treatment of parkinson's disease.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Uptake mechanism and intracellular destiny of liposomes in RES

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of Ascorbic Acid on the Metabolic Fate and the Hepatitis of Hydrazine Derivatives

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of intracellular drug delivery system utilizing liposomesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Cationic liposomes and tumour vasculature targeting : a therapeutic approach that has potential for solid tumours2011

Author(s)

Publisher

Data Source

KIWADA Hiroshi 際田弘志