DEGAWA Masakuni 出川雅邦

… Alternative Names

Researcher Number	50134002
Affiliation (Current)	2021: 静岡県立大学, 薬学部, 客員教授
Affiliation (based on the past Project Information) *help	2012: 静岡県立大学, 薬学部, 教授 2005 – 2006: 静岡県立大学, 薬学部, 教授 2002 – 2003: 静岡県立大学, 薬学部, 教授 1998 – 1999: 静岡県立大学, 薬学部, 教授 1992 – 1997: 東北大学, 薬学部, 助手 1986 – 1988: 東北大学, 薬学部, 助手 1985: 東北大学, 薬, 助手
Review Section/Research Field	Principal Investigator Environmental pharmacy / Biological pharmacy / Environmental pharmacy Except Principal Investigator Medical pharmacy / Biological pharmacy
Keywords	Principal Investigator cytochrome P450 / lead nitrate / 精巣 / 性差 / CYP / 肝臓 / Trp-P-1 / CYPLA2 / heavy metal / rat … More Except Principal Investigator 代謝的活性化 / 化学発癌 / DNA傷害 / 性差 / 活性中間体 / DNA修復 / DNA付加体 / P450 / チトクロムP-450 / 種差 / ヘテロサイクリックアミン / ニトロピレン / チトクロームP-450 / 細胞増殖 / アセチル化酵素 / dexamethazone / cyclophosphamide / tumor / アリルアミン / 硫酸転移酵素 / 分子多型 / 遺伝子構造 / RT-PCR / STICI / ヒト遺伝子 / EST / アンドロゲン / 薬物代謝酵素 / 肝臓 / CYP / 系統差 / 優性遺伝 / ブタ / 第II相薬物代謝酵素 / 構成的発現 / IL-1 / Cyp7a1 / PGC-1α / アンドロゲン濃度 / 常染色体性優性遺伝 / 転写因子 / CYP1A1 / CYP1A2 / 品種間差 / サルフォトランスフェラ-ゼ / O-アセチラ-ゼ / チトクロムPー450 / サルフォトランスフェラーゼ / Oーアセチラーゼ / ヒトへの外挿 / N-水酸化体 / 薬物代謝 / 異種細胞発現 / チトクロームP450 / 酵母 / ヒト薬物代謝 / 遺伝子発現系 / CYP2C9 / CYP2C18 / CYP2C19 / S.Pombe / P450還元酵素 / ミクロソーム / cDNA発現 / Drug Metabolism / Cytochrome P450 / Heterologous expression / Stable Expression Less

Inhibitory effect of androgen on the constitutive gene expression of hepatic drug metabolizing enzymes and its mechanism
- Principal Investigator
  
  KOJIMA Misaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  National Institute of Agrobiological Sciences
Study on toxic effects of endocrine disruptors and their species-, gender-, and age-related differencesPrincipal Investigator
- Principal Investigator
  
  DEGAWA Masakuni
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  University of Shizuoka
環境化学物質による非神経組織障害と神経栄養因子誘導との関連Principal Investigator
- Principal Investigator
  
  出川雅邦
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  University of Shizuoka
INTRACELLULAR CALCIUM ION-RELATED GENE EXPRESSION OF CYTOCHROMES P450Principal Investigator
- Principal Investigator
  
  DEGAWA Masakuni
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  University of Shizuoka
ヒト発がん感受性に関するアリルアミン硫酸転移酵素の遺伝子の単離と多型性解析
- Principal Investigator
  
  山添康
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
がん化に伴う肝P450分子種の変動とその特徴;治療への応用を目指して
- Principal Investigator
  
  YAMAZOE Yasushi
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Development of as table expression system for human drug metabolizing enzymes
- Principal Investigator
  
  YAMAZOE Yasushi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
重金属類によるチトクロームP450の発現誘導体の阻害とその特徴Principal Investigator
- Principal Investigator
  
  出川雅邦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
化学発癌における活性中間体の動態と標的臓器DNA傷害-臓器および種特異性との関連
- Principal Investigator
  
  加藤隆一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Keio University
化学発癌における活性中間体の動態と標的臓番DNA傷害ー臓器よおび種特異性との関連
- Principal Investigator
  
  加藤隆一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Keio University
癌原物質の代謝的活性化機構と発癌の特異性に関する研究ーー特にヒトの外挿
- Principal Investigator
  
  加藤隆一
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Keio University
癌原物質の代謝的活性化機構と発癌の特異性に関する研究ー特にヒトへの外挿
- Principal Investigator
  
  加藤隆一
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Keio University
芳香族アミンに対する発癌感受性支配因子としての薬物代謝酵素の変動Principal Investigator
- Principal Investigator
  
  出川雅邦
- Project Period (FY)
  1985
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
癌原物質の代謝的活性化機構と発癌の特異性に関する研究-特にヒトへの外挿-
- Principal Investigator
  
  加藤隆一
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Keio University

All 2013 2012 2011 2010 2006 2005 Other

All Journal Article Presentation

[Journal Article] Serum androgen level is determined by autosomal dominant inheritance and regulates sex-related CYP genes in pigs2013
- Author(s)
  M. Kojima and M. Degawa
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 430 Pages: 833-838
- DOI
  10.1016/j.bbrc.2012.11.060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590166
[Journal Article] Involvement of Interleukin-1 in Lead Nitrate-Induced Hypercholesterolemia in Mice2012
- Author(s)
  M.Kojima
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 35 Issue: 2 Pages: 246-250
- DOI
  10.1248/bpb.35.246
- NAID
  130001872300
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009, KAKENHI-PROJECT-22590166
[Journal Article] Interleukin-1 Controls the Constitutive Expression of the Cyp7a1 Gene by Regulating the Expression of Cyp7a1 Transcriptional Regulators in the Mouse Liver2011
- Author(s)
  M.Kojima
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 34 Issue: 10 Pages: 1644-1647
- DOI
  10.1248/bpb.34.1644
- NAID
  130001086603
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009, KAKENHI-PROJECT-22590166
[Journal Article] Androgn-mediated down-regulation of CYP1A subfamily genes in the pig liver2010
- Author(s)
  M. Kojima, M. Sekimoto and M. Degawa
- Journal Title
  
  J. Endocrinol
  
  Volume: 207 Pages: 203-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590166
[Journal Article] Androgen-mediated down-regulation of CYP1A subfamily genes in the pig liver2010
- Author(s)
  M.Kojima, M.Sekimoto, M.Degawa
- Journal Title
  
  J.Endocrinol
  
  Volume: 207 Pages: 203-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590166
[Journal Article] The induction of hepatic cytochrome P4501A subfamily enzymes by nitroanisidines : Species difference among experimental rodents.2006
- Author(s)
  Souma, S, Sekimoto, M, Degawa, M
- Journal Title
  
  Journal of Health Science 52(4)
  
  Pages: 469-474
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590104
[Journal Article] Gender-related difference in altered gene expression of a sterol regulatory element binding protein, SREBP-2, by lead nitrate in rats : Correlation with development of hypercholesterolemia.2006
- Author(s)
  Kojima, M, Degawa, M
- Journal Title
  
  Journal of Applied Toxicology 26(4)
  
  Pages: 381-384
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590104
[Journal Article] A hepatocarcinogenic tryptophairpyrolyzate component, Trp-P-1, decreases serum total testosterone level and induces hepatic Cyp la2 in male CDF_1 mice.2006
- Author(s)
  Degawa M, Hanaki K, Sekimoto M
- Journal Title
  
  Cancer Science 97・1
  
  Pages: 32-37
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590104
[Journal Article] Cloning of chicken lanosterol 14 α -demethylase (CYP51) cDNA : Discovery of a testis-specific C YP51 transcript.2006
- Author(s)
  Kojima, M, Tagami, T, Degawa, M
- Journal Title
  
  Comparative Biochemistry and Physiology 145・3
  
  Pages: 383-389
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590104
[Journal Article] A hepatocarcinogenic tryptophan-pyrolyzate component, Trp-P-1, decreases serum total testosterone level and induces hepatic Cypla2 in male CDF_1 mice.2006
- Author(s)
  Degawa M, Hanaki K, Sekimoto M
- Journal Title
  
  Cancer Science 97(1)
  
  Pages: 32-37
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590104
[Journal Article] Gender-related difference in altered gene expression of a sterol regulatory element binding protein, SREBP-2, by lead nitrate in rats : Correlation with development of hypercholesterolemia.2006
- Author(s)
  Kojima, M, Degawa, M
- Journal Title
  
  Journal of Applied Toxicology 26・4
  
  Pages: 381-384
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590104
[Journal Article] Species difference in the induction of hepatic CYP1A subfamily enzymes, especially CYP1A2, by 2-methoxy-4-nitroaniline among rats, mice, and guinea pigs.2006
- Author(s)
  Souma, S, Sekimoto, M, Degawa, M
- Journal Title
  
  Archives of Toxicology 80・10
  
  Pages: 739-747
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590104
[Journal Article] Species difference in the induction of hepatic CYP1A subfamily enzymes, especially CYP1A2, by 2-methoxy-4-nitroaniline among rats, mice, and guinea pigs.2006
- Author(s)
  Souma, S, Sekimoto, M, Degawa, M
- Journal Title
  
  Archives of Toxicology 80(10)
  
  Pages: 739-747
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590104
[Journal Article] A hepatocarcinogenic tryptophan-pyrolyzate component, Trp-P-1, decreases serum total testosterone level and induces hepatic Cyp1a2 in male CDF_1 mice.2006
- Author(s)
  Degawa M, Hanaki K, Sekimoto M
- Journal Title
  
  Cancer Science 97・1
  
  Pages: 32-37
- Data Source
  KAKENHI-PROJECT-17590104
[Journal Article] Cloning of chicken lanosterol 14 α-demethylase (CYP51)cDNA : Discovery of a testis-specific CYP51 transcript.2006
- Author(s)
  Kojima, M, Tagami, T, Degawa, M
- Journal Title
  
  Comparative Biochemistry and Physiology 145・3
  
  Pages: 383-389
- Data Source
  KAKENHI-PROJECT-17590104
[Journal Article] Cloning of chicken lanosterol 14α-demethylase (CYP51) cDNA : Discovery of a testis-specific CYP51 transcript.2006
- Author(s)
  Kojima, M, Tagami, T, Degawa, M
- Journal Title
  
  Comparative Biochemistry and Physiology 145(3)
  
  Pages: 383-389
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590104
[Journal Article] The induction of hepatic cytochrome P4501A subfamily enzymes by nitroanisidines : Species difference among experimental rodents.2006
- Author(s)
  Souma, S, Sekimoto, M, Degawa, M
- Journal Title
  
  Journal of Health Science 52・4
  
  Pages: 469-474
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590104
[Journal Article] Decrease in serum thyroxine level by phenobarbital in rats is not necessarily dependent on increase in hepatic UDP-glucuronosyltransferase.2005
- Author(s)
  Kato Y, Suzuki H, Ikushiro S, Yamada S, Degawa M
- Journal Title
  
  Drug Metabolism and Disposition 33(11)
  
  Pages: 1608-1612
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590104
[Journal Article] The decrease in level of serum thyroxine by 2, 2', 4, 5, 5'-pentachlorobiphenyl in rats and mice : no correlation with formation of methylsulfonyl metabolites.2005
- Author(s)
  Kato Y, Haraguchi K, Yamazaki T, Kimura R, Koga N, Yamada S, Degawa M
- Journal Title
  
  Drug Metabolism and Disposition 33・11
  
  Pages: 1661-1665
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590104
[Journal Article] The decrease in level of serum thyroxine by 2, 2', 4, 5, 5'-pentachlorobiphenyl in rats and mice : no correlation with formation of methylsulfonyl metabolites.2005
- Author(s)
  Kato Y, Haraguchi K, Yamazaki T, Kimura R, Koga N, Yamada S, Degawa M
- Journal Title
  
  Drug Metabolism and Disposition 33(11)
  
  Pages: 1661-1665
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590104
[Journal Article] Tumor necrosis factor-α-independent down-regulation of hepatic cholesterol 7α-hydroxylase gene in mice treated with lead nitrate.2005
- Author(s)
  Kojima M, Sekikawa K, Nemoto K, Degawa M
- Journal Title
  
  Toxicological Sciences 87・2
  
  Pages: 537-542
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590104
[Journal Article] Tumor necrosis factor-a-independent down-regulation of hepatic cholesterol 7a-hydroxylase gene in mice treated with lead nitrate.2005
- Author(s)
  Kojima M, Sekikawa K, Nemoto K, Degawa M
- Journal Title
  
  Toxicological Sciences 87・2
  
  Pages: 537-542
- Data Source
  KAKENHI-PROJECT-17590104
[Journal Article] necrosis factor-a-independent down-regulation of hepatic cholesterol 7 a-hydroxylase gene in mice treated with lead nitrate.2005
- Author(s)
  Kojima M, Sekikawa K, Nemoto K, Degawa M, Tumor
- Journal Title
  
  Toxicological Sciences 87(2)
  
  Pages: 537-542
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590104
[Journal Article] Decrease in serum thyroxine level by phenobarbital in rats is not necessarily dependent on increase in hepatic UDP-glucuronosyltransferase2005
- Author(s)
  Kato Y, Suzuki H, Ikushiro S, Yamada S, Degawa M
- Journal Title
  
  Drug Metabolism and Disposition 33・11
  
  Pages: 1608-1612
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590104
[Journal Article] The decrease in level of serum thyroxine by 2, 2', 4, 5, 5'-pentachlorobiphenyl in rats and mice: no correlation with formation of methylsulfonyl metabolites.2005
- Author(s)
  Kato Y, Haraguchi K, Yamazaki T, Kimura R, Koga N, Yamada S, Degawa M.
- Journal Title
  
  Drug Metabolism and Disposition 33・11
  
  Pages: 1661-1665
- Data Source
  KAKENHI-PROJECT-17590104
[Presentation] Sex-differences in the constitutive gene expression levels of CYPs in the pig liver2012
- Author(s)
  Misaki Kojima, Masashi Sekimoto, Masakuni Degawa
- Organizer
  Androgen-mediated downregulation. 50th Anniversary Symposium on Cytochrome
- Place of Presentation
  福岡
- Year and Date
  2012-12-03
- Data Source
  KAKENHI-PROJECT-22590166
[Presentation] マウス肝でのcholesterol 7α-hydroxylaseおよびその転写因子の構成的遺伝子発現におけるInterleulin-1の寄与2012
- Author(s)
  小島美咲、芦野隆、吉田武美、岩倉洋一郎、関本征史、出川雅邦
- Organizer
  フォーラム2012:衛生薬学・環境トキシコロジー
- Place of Presentation
  名古屋
- Year and Date
  2012-10-25
- Data Source
  KAKENHI-PROJECT-22590166
[Presentation] ブタの肝臓における構成的CYP2およびCYP3ファミリー酵素の遺伝子発現に及ぼすアンドロゲンの影響2011
- Author(s)
  小島美咲、出川雅邦
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-22590166
[Presentation] ブタにおける血清中アンドロゲン濃度は遺伝的に規定され、肝CYP1A酵素遺伝子の発現に影響を与える2011
- Author(s)
  小島美咲、出川雅邦
- Organizer
  第84回日本生化学会
- Place of Presentation
  京都
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-22590166
[Presentation] マウス肝でのcholetserol 7α-hydroxylaseおよびその転写因子の構成的遺伝子発現におけるInterleulin-1の寄与
- Author(s)
  小島美咲、芦野隆、吉田武美、岩倉洋一郎、関本征史、出川雅邦
- Organizer
  フォーラム2012：衛生薬学・環境トキシコロジー
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22590166
[Presentation] Sex-differences in the constitutive gene expression levels of CYPs in the pig liver: Androgen-mediated Dwonregulation
- Author(s)
  M. Koima, M. Sekimoto and M. Degawa
- Organizer
  50th Anniversary Symposium on Cytochrome P450 in Fukuoka
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22590166

1. 加藤隆一 (40112685)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. 渡部烈 (00057316)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. YAMAZOE Yasushi (00112699)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. NEMOTO Kiyomitsu (90189366)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
5. 大西克成 (10037400)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 渡辺民朗 (40006101)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. SUZUKI Shinya (40196829)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. NAGATA Kiyoshi (80189133)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 石川隆俊 (30085633)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 多田万里子 (90073113)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 若林敬二 (60158582)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 大垣比呂子 (00150201)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. KOJIMA Misaki (80355742)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
14. 江角浩安 (70160364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KUMAGAI Hiromichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TAINAKA Hitoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MA GUANGYU

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

DEGAWA Masakuni 出川 雅邦

出川 雅邦 デガワ マサクニ

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Study on toxic effects of endocrine disruptors and their species-, gender-, and age-related differencesPrincipal Investigator

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環境化学物質による非神経組織障害と神経栄養因子誘導との関連Principal Investigator

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INTRACELLULAR CALCIUM ION-RELATED GENE EXPRESSION OF CYTOCHROMES P450Principal Investigator

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重金属類によるチトクロームP450の発現誘導体の阻害とその特徴Principal Investigator

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芳香族アミンに対する発癌感受性支配因子としての薬物代謝酵素の変動Principal Investigator

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[Journal Article] Serum androgen level is determined by autosomal dominant inheritance and regulates sex-related CYP genes in pigs2013

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DOI

Data Source

[Journal Article] Involvement of Interleukin-1 in Lead Nitrate-Induced Hypercholesterolemia in Mice2012

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DEGAWA Masakuni 出川雅邦

出川雅邦デガワマサクニ