HIRATA Yukio 平田結喜緒

Researcher Number	50135787
Other IDs
Affiliation (based on the past Project Information) *help	2007 – 2008: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 2006: 東京医科歯科大学, 大学院医歯学総合研究科, 教授 2000 – 2005: 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 1995 – 1999: 東京医科歯科大学, 医学部, 助教授 1988 – 1993: Second Department of Internal Medicine, Tokyo Medical&Dental University, 医学部, 助教授 1991: 東京医科大学, 医学部, 助教授 1987: 国立循環器病センター研究所, 病因部, 室長
Review Section/Research Field	Principal Investigator 内分泌・代謝学 / Anesthesiology/Resuscitation studies / Endocrinology / Biological Sciences / 内科学一般 / General internal medicine (including Psychosomatic medicine) / Circulatory organs internal medicine / Kidney internal medicine Except Principal Investigator 内科学一般 / 内分泌・代謝学 / General internal medicine (including Psychosomatic medicine) / Biological Sciences
Keywords	Principal Investigator サイトカイン / 誘導型NO合成酵素 / エンドセリン / 血管平滑筋 / 敗血症性ショック / アポトーシス / 血管リモデリング / VSMC / CRLR / RAMP … More / 一酸化窒素 / Protein kinase C / Signal transduction / 合成と分泌機序 / ホルモン / 細胞内Ca^<2+> / Cキナ-ゼ / 情報伝達 / NF-kB / 一酸化窒素(NO) / Inositol phosphate / Muscarinic cholinergic agonsit / -Adrenergic agonist / Thyroid hormone / Androgen / Glucocorticoid / Mechanism of synthesis and secretion / Cultured rat cardiocytes / Atrial natriuretic peptide / 糖質コルチコイド / 分泌様式 / 培養心筋細胞 / 培養心房細胞 / 心房性Na利尿ペプテド / Cキナーゼ / イノシトール燐酸 / ムスカリン性コリン作働薬 / α_1交感作働薬 / 甲状腺ホルモン / 男性ホルモン / 糖質ステムイド / 培養ラット心筋細胞 / 心房性Na利尿ペプチド / glucocorticoid / cytokines / nuclear factor (NF)-kB / apoptosis / atherosclerosis / Vascular Smooth Muscle / inducible NO synthase (iNOS) / nitric oxide (NO) / スフィンゴミエリナーゼ / NF-KB / 誘導型NO合成酸素 / 非ステロイド性消炎剤 / 糖質ステロイド / Vascular Remodeling / Adrenomedullin / MAPキナーゼ / チロシンキナーゼ / 増殖 / Max / c-Myc / 内皮 / 内皮障害 / 細胞遊走 / アドレノメデュリン / Endotoxin shock / Rheumatoid arthritis / Cytokines / Vascular endothelium / Inducible nitric oxide synthase / 一酸化窒素合成酵素 / エンドトキシンショック / 慢性関節リュウマチ / 血管内皮 / G-protein / Receptor subtype / Regulation of Gene expression / Endothelin / 細胞増殖 / 遺伝子発現 / ホスホイノシト-ル / レセプタ-サブタイプ / エンドセリンー1 / 局所因子 / 発現 / レセプター / 血管肥厚 / 心肥大 / レセプターアンタゴニスト / G蛋白 / 細胞内情報伝達 / レセプターサブタイプ / 遺伝子発現調節 / Hypertension / Intracellular Ca^<2+> / Phosphatidylinositol / Receptor / Endothelium / 腎上皮細胞 / 構造活性相関 / 増殖因子 / 血管収縮因子 / オ-トクリン / フォスファチジ-ルイノシト-ル(PI) / 血管収縮 / 高血圧 / 細胞内カルシウム / フォスファテジルイノシト-ル(PI) / 情報伝達系 / レセプタ- / 機能解析 / ペプチド性ホルモン / ペプチド創薬 / 生理活性ペプチド / in silico / ペプチドライブラリー / バイオインフォマティクス / 生理活性物質 / 受容体 / 発現調節 / サルーシン / 遺伝子導入 / siRNA / ウロテンシンII / IkB / NO / 遺伝子治療 / アンチセンスオリゴマー … More Except Principal Investigator 血管内皮細胞 / c-Myc / Congestive heart failure / プロセシング / 心不全 / エンドセリン / Metastasis / Vascular endothelial cell / Endothelial apoptosis / Anti-tumor effect / Endothelial cell growth / Endothelial cell migration / Endostatin / Antiangiogenesis signal / 細胞増殖 / 細胞遊走 / 血管新生 / 転移抑制作用 / 内皮アポトーシス / 抗腫瘍作用 / 内皮細胞増殖 / 内皮細胞遊走 / エンドスタチン / 血管新生抑制シグナル / Smooth muscle cells / Endothelial cells / MAP Kinase / Apoptosis / Endothelin-1 / ジーン・ターゲティング / 線維芽細胞 / MAPキナーゼ / 血管平滑筋細胞 / MAPチナーゼ / アポトーシス / Myocardial infarction / Atrial natriuretic peptide / Brain natriuretic peptide / 心房性Na利尿ペプチド(ANP) / 脳性Na利尿ペプチド(BNP) / サイトカイン / 発現調節 / 心筋細胞 / ストレス / ANP / BNP / Acute myocardial in farction / Atrial netriuretic peptide / Brain netriuretic peptide / Processing / Renal Failure / Heart Failure / alpha-ANP / beta-ANP / atrial natriuretic peptide (ANP) / 心房細胞 / 脳性Na利尿ホルモン / β-ANP / プロセシング機序 / 心疾患 / 心房性Na利尿ホルモン / 賢不全 / αーANP / βーANP / 心房性Na利尿ホルモン(ANP) / 血管作動性ペプチド / バイオインフォマティクス / ET_B受容体 / ET_A受容体 / アドレノメデュリン / big ET / 脳血管攣縮 / 内皮細胞腫瘍 / ET受容体 / ホスホラミドン / 変換酵素 / bigET / アイソフォーム / エンドセリン(ET) Less

Exploring drug target peptides utilizing in silico analysisPrincipal Investigator
- Principal Investigator
  
  HIRATA Yukio
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Tokyo Medical and Dental University
新規降圧ペプチド(salusin)の発現調節と心臓での受容体・情報伝達系の解明Principal Investigator
- Principal Investigator
  
  平田結喜緒
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
腎内ウロテンシンIIのsiRNAを用いた遺伝子発現制御による病態生理学的意義の解明Principal Investigator
- Principal Investigator
  
  平田結喜緒
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokyo Medical and Dental University
Targeting antiangiogenesis inhibitor using antiangiogenesis molecular signals
- Principal Investigator
  
  SHICHIRI Masayoshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Tokyo Medical and Dental University
バイオインフォマティクスを応用した新規血管作動性ペプチドの探索
- Principal Investigator
  
  七里眞義
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
NF-kB活性化経路の特異的阻害による敗血症性ショックの遺伝子治療Principal Investigator
- Principal Investigator
  
  平田結喜緒
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokyo Medical and Dental University
誘導型NO合成酵素発現の特異的阻害による敗血症性ショックの遺伝子治療Principal Investigator
- Principal Investigator
  
  平田結喜緒
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokyo Medical and Dental University
Molecular Biological Study on Adrenomedullin and Vascular RemodelingPrincipal Investigator
- Principal Investigator
  
  HIRATA Yukio
- Project Period (FY)
  1998 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Regulation of gene expression of inducible nitric oxide synthase (iNOS) in cardiovascular system and its molecular mechanism of actionPrincipal Investigator
- Principal Investigator
  
  HINATA Yukio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Endocrinology
- Research Institution
  Tokyo Medical and Dental University
Molecular mechanisms of apoptotic regulation by endothelin
- Principal Investigator
  
  SHICHIRI Masayoshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Tokyo Medical and Dental University
エンドセリン-1によるアポートシスの制御
- Principal Investigator
  
  SHICHIRI Masayoshi
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Tokyo Medical and Dental University
Pysiological and pathophysiological roles of nitric oxide (NO) and NOS synthasesPrincipal Investigator
- Principal Investigator
  
  HIRATA Yukio
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Tokyo Medical & Dental University
Clinical Significance of Brain Natriuretic Peptide (BNP) in Cardiac Diseases
- Principal Investigator
  
  MARUMO Fumitaki
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Tokyo Medical and Dental University
Mechanism of Biosynthesis and Secretion of Endothelin FamilyPrincipal Investigator
- Principal Investigator
  
  HIRATA Yukio
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Tokyo Medical and Dental University
エンドセリンの薬理学的研究
- Principal Investigator
  
  真崎知生, 眞崎智生 (眞崎知生)
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  University of Tsukuba
  Kyoto University
With Cardiac Disease with Special Emphasis on -ANP Clinical Significant of Atrial Natriuretic Peoptide in Patients
- Principal Investigator
  
  MARUMO Fumiaki
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Tokyo Medical and Dental university, School of Medicine
The Cellular Mechanism of Action by Endothelium and Its Synthetic and Sectretory MechanismPrincipal Investigator
- Principal Investigator
  
  HIRATA Yukio
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Tokyo Medical & Dental University School of Medicine
Cellular Mechanism of Synthesis and Secretion of Atrial Natriuretic Peptide in Cultured Rat CardiocytesPrincipal Investigator
- Principal Investigator
  
  HIRATA Yukio
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Tokyo Medical and Dental University
  National Cardiovascular Center Research Institute

All 2009 2008 2007 2006 2005 2004 2003

All Journal Article Presentation Book

[Book] Annual Review 20052005
- Author(s)
  七里眞義, 平田結喜緒
- Data Source
  KAKENHI-PROJECT-15390219
[Book] Adrenomedullin receptor and signal transduction. In Adrenomedullin in Cardiovascular Disease2005
- Author(s)
  Yoshimoto T, Hirata Y
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-17390228
[Book] Annual Review 20052005
- Author(s)
  七里眞義, 平田結喜緒
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390219
[Journal Article] Expression of prosalusin in human neuroblastoma cells2009
- Author(s)
  Nakayama C, Shichiri M, Sato K, Hirata Y
- Journal Title
  
  Peptides 30
  
  Pages: 1362-7
- Data Source
  KAKENHI-PROJECT-19209026
[Journal Article] Nitric oxide upregulates dimethylarginine dimethylaminohydrolase-2 via cyclic GMP induction in endothelial cells2008
- Author(s)
  Sakurada M, Shichiri M, Imamura M, Azuma H, Hirata Y
- Journal Title
  
  Hypertension 52
  
  Pages: 903-9
- Data Source
  KAKENHI-PROJECT-19209026
[Journal Article] Aldosterone induces superoxide generation via Rac1 activation in endothelial cells2008
- Author(s)
  Iwashima F, Yoshimoto T, Minami I, Sakurada M, Hirono Y, Hirata Y
- Journal Title
  
  Endocrinology 149
  
  Pages: 1009-14
- Data Source
  KAKENHI-PROJECT-19209026
[Journal Article] Chronic osmotic stimuli increase salusin-β-like immunoreactivity in the rat hypothalamo-neurohypophyseal system : possible involvement of salusin-β on [Ca^<2+>]_i increase and neurohypophyseal hormone release from the axon terminals2008
- Author(s)
  Saito T, Dayanithi G, Saito J, Onaka T, Urabe T, Watanabe TX, Hashimoto H, Yokoyama T, Fujihara H, Yokota A, Nishizawa S, Hirata Y, Ueta Y
- Journal Title
  
  J Neuroendocrinol 20
  
  Pages: 207-19
- Data Source
  KAKENHI-PROJECT-19209026
[Journal Article] Aldosterone-stimulated SGK1 activity mediates profibrotic signaling in the mesangium2008
- Author(s)
  Terada Y, Kuwana H, Kobayashi T, Okado T, Suzuki N, Yoshimoto T, Hirata Y, Sasaki S
- Journal Title
  
  J Am Soc Nephrol 19
  
  Pages: 298-309
- Data Source
  KAKENHI-PROJECT-19209026
[Journal Article] NO upregulates dimethylarginine dimethylaminohydrolase-2 via cGMP induction in endothelial cells2008
- Author(s)
  Sakurada M, Shichiri M, Imamura M, Azuma H, Hirata Y
- Journal Title
  
  Hypertension 52
  
  Pages: 903-909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209026
[Journal Article] Negative regulation by SHPS-1 of Toll-like receptor-dependent proinflammatory cytokine production in macrophages2008
- Author(s)
  Miyake A, Murata Y, Okazawa H, Ikeda H, Niwayama Y, Ohnishi H, Hirata Y, Matozaki T
- Journal Title
  
  Genes to Cells 13
  
  Pages: 209-19
- Data Source
  KAKENHI-PROJECT-19209026
[Journal Article] Aldosterone as a cardiovascular risk hormone2007
- Author(s)
  Yoshimoto T, Hirata Y
- Journal Title
  
  Endocrine J 54
  
  Pages: 359-70
- NAID
  130004770030
- Data Source
  KAKENHI-PROJECT-19209026
[Journal Article] Defective expression of prohormone convertase 1/3 in silent corticotroph adenoma2007
- Author(s)
  Tateno T, Izumiyama H, Doi M, Akashi T, Ohno K, Hirata Y
- Journal Title
  
  Endocrine J 54
  
  Pages: 777-82
- NAID
  10020093046
- Data Source
  KAKENHI-PROJECT-19209026
[Journal Article] MARCH-X1, a novel transmembrane ubiquitin ligase implicated in ubiquitin-dependent protein sorting in developing spermatids2007
- Author(s)
  Morokuma Y, Nakamura N, Kato A, Notoya M, Yamamoto Y, Sakai Y, Fukuda H, Yamashina S, Hirata Y, Hirose S
- Journal Title
  
  J Biol Chem 282
  
  Pages: 24806-15
- Data Source
  KAKENHI-PROJECT-19209026
[Journal Article] Angiotensin II receptor type 1-mediated vascular oxidative stress and proinflammatory gene expression in aldosterone-induced hypertension : the possible role of local renin-angiotensin system2007
- Author(s)
  Hirono Y, Yoshimoto T, Suzuki N, Sugiyama T, Sakurada M, Takai S, Kobayashi N, Shichiri M, Hirata Y
- Journal Title
  
  Endocrinology 148
  
  Pages: 1688-96
- Data Source
  KAKENHI-PROJECT-19209026
[Journal Article] Systemic distribution of salusin expression in the rats2007
- Author(s)
  Suzuki N, Shichiri M, Akashi T, Sato K, Sakurada M, Hirono Y, Yoshimoto T, Koyama T, Hirata Y
- Journal Title
  
  Hypertens Res 30
  
  Pages: 1255-62
- NAID
  10021260743
- Data Source
  KAKENHI-PROJECT-19209026
[Journal Article] Differential gene expression in adrenocorticotropin (ACTH)-secreting and non-functioning pituitary tumors2007
- Author(s)
  Tateno T, Izumiyama H, Doi M, Yoshimoto T, Shichiri M, Inosita M, Oyama K, Yamada S, Hirata Y
- Journal Title
  
  Eur J Endocrinol 157
  
  Pages: 717-24
- Data Source
  KAKENHI-PROJECT-19209026
[Journal Article] Chronic blockade of nitric oxide synthesis reduces adiposity and improves insulin resistance in high-fat-induced obese mice2007
- Author(s)
  Tsuchiya K, Sakai H, Suzuki N, Iwashima F, Yoshimoto T, Shichiri M, Hirata Y
- Journal Title
  
  Endocrinology 148
  
  Pages: 4548-56
- Data Source
  KAKENHI-PROJECT-19209026
[Journal Article] Presence of immunoreactive salusin-alpha in human serum and urine2006
- Author(s)
  Sato K, Koyama T, Tateno T, Hirata Y, Shichiri M
- Journal Title
  
  Peptides 27.11
  
  Pages: 2561-2566
- Data Source
  KAKENHI-PROJECT-17390228
[Journal Article] Synthetic salusins as cardiac depressors in rat.2005
- Author(s)
  Izumiyama H, Tanaka H, Egi K, Sunamori M, Hirata Y, Shichiri M
- Journal Title
  
  Hypertension (in press)
- Data Source
  KAKENHI-PROJECT-15390219
[Journal Article] Aldosterone induces angiotensin converting enzyme (ACE) gene expression via JAK2-dependent pathway in rat endothelial cells.2005
- Author(s)
  Sugiyama T, Yoshimoto T, Tsuchiya K, Gochou N, Hirono Y, Tateno T, Fukai N, Shichiri M, Hirata Y
- Journal Title
  
  Endocrinology 146・9
  
  Pages: 3900-3906
- Data Source
  KAKENHI-PROJECT-16659220
[Journal Article] Adrenomedullin inhibits angiotensin II-induced oxidative stress and gene expression in rat endothelial cells.2005
- Author(s)
  Yoshimoto T, Fukai N, Sugiyama T, Shichiri M, Hirata Y
- Journal Title
  
  Hypertension Research 28
  
  Pages: 165-172
- NAID
  10016430788
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390219
[Journal Article] Concomitant expression of adrenomedullin and its receptor components in rat adipose tissues.2005
- Author(s)
  Fukai N, Yoshimoto T, Sugiyama T, Ozawa N, Sato R, Shichiri M, Hirata Y
- Journal Title
  
  American Journal of Physiology (Endocrinol Metab) (in press)
- Data Source
  KAKENHI-PROJECT-15390219
[Journal Article] Concomitant expression of adrenomedullin and its receptor components in rat adipose tissues.2005
- Author(s)
  Fukai N, Yoshimoto T, Sugiyama T, Ozawa N, Sato R, Shichiri M, Hirata Y
- Journal Title
  
  Am J Physiol (Endocrinol Metab) 288
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390219
[Journal Article] Aldosterone increases osteopontin gene expression in rat endothelial cells.2005
- Author(s)
  Sugiyama T, Yoshimoto T, Hirono Y, Sakurada M, Tsuchiya K, Minami I, Iwashima F, Sakai H, Tateno T, Sato R, Hirata Y
- Journal Title
  
  Biochemical Biophysical Research Communication 336.1
  
  Pages: 163-167
- Data Source
  KAKENHI-PROJECT-16659220
[Journal Article] Concomitant expression of adrenomedullin and its receptor components in rat adipose tissues.2005
- Author(s)
  Fukai N, Yoshimoto T, Sugiyama T, Ozawa N, Sato R, Shichiri M, Hirata Y
- Journal Title
  
  American Journal of Physiology 288・1
- Data Source
  KAKENHI-PROJECT-16659220
[Journal Article] Synthetic salusins as cardiac depressors in rat.2005
- Author(s)
  Izumiyama H, Tanaka H, Egi K, Sunamori M, Hirata Y, Shichiri M
- Journal Title
  
  Hypertension 45
  
  Pages: 419-425
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390219
[Journal Article] Adrenomedullin inhibits angiotensin II-induced oxidative stress and gene expression in rat endothelial cells.2005
- Author(s)
  Yoshimoto T, Gochou N, Fukai N, Sugiyama T, Shichiri M, Hirata Y
- Journal Title
  
  Hypertension Research 28・2
  
  Pages: 165-172
- NAID
  10016430788
- Data Source
  KAKENHI-PROJECT-16659220
[Journal Article] Concomitant expression of adrenomedullin and its receptor components in rat adipose tissues.2005
- Author(s)
  Fukai N, Yoshimoto T, Sugiyama T, Ozwa N, Sato R, Shichiri M, Hirata Y
- Journal Title
  
  American Journal of Physiology (Endocrinol Metab) 288
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390219
[Journal Article] Adrenomedullin inhibits angiotensin II-induced oxidative stress and gene expression in rat endothelial cells.2005
- Author(s)
  Yoshimoto T, Fukai N, Sugiyama T, Shichiri M, Hirata Y
- Journal Title
  
  Hypertension Research (in press)
- NAID
  10016430788
- Data Source
  KAKENHI-PROJECT-15390219
[Journal Article] Adrenomedullin inhibits angiotensin II-induced oxidative stress and gene expression in rat endothelial cells.2005
- Author(s)
  Yoshimoto T, Gochou N, Fukai N, Sugiyama T, Shichiri M, Hirata Y
- Journal Title
  
  Hypertens Res-Clinical & Experimental. 28
  
  Pages: 165-172
- NAID
  10016430788
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390219
[Journal Article] Role of urotensin II in peripheral tissue as an autocine/paracrine growth factor2004
- Author(s)
  Yoshimoto T, Matsushita M, Hirata Y
- Journal Title
  
  Peptides 25.10
  
  Pages: 1775-1781
- Data Source
  KAKENHI-PROJECT-16659220
[Journal Article] Regulation of adrenomedullin gene transcription and degradation by the c-myc gene.2004
- Author(s)
  Ozawa N, Shichiri M, Fukai N, Yoshimoto T, Hirata Y
- Journal Title
  
  Endocrinology 145
  
  Pages: 4244-4250
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390219
[Journal Article] Antioxidant effect of adrenomedullin on angiotensin II-induced reactive oxygen species generation in vascular smooth muscle cells.2004
- Author(s)
  Yoshimoto T, Fukai N, Sato R, Sugiyama T, Ozawa N, Shichiri M, Hirata Y
- Journal Title
  
  Endocrinology 145
  
  Pages: 3331-3337
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390219
[Journal Article] Endothelin-1 induces cyclooxygenase-2 expression and generation of reactive oxygen species in endothelial cells.2004
- Author(s)
  Sugiyama T, Yoshimoto T, sato R, Fukai N, Ozawa N, Shichiri M, Hirata Y
- Journal Title
  
  J Cardiovasc Pharmacol 44
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390219
[Journal Article] Laminar shear stress upregulates inducible nitric oxide synthase in the endothelium.2004
- Author(s)
  Ozawa N, Shichiri M, Iwashina M, Fukai N, Yoshimoto T, Hirata Y
- Journal Title
  
  Hypertens Res-Clinical & Experimental. 27
  
  Pages: 93-99
- NAID
  10012843557
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390219
[Journal Article] Adrenomedullin is an autocrine/paracrine growth factor for rat vascular smooth muscle cells.2003
- Author(s)
  Shichiri M, Fukai N, Ozawa N, Iwasaki H, Hirata Y
- Journal Title
  
  Regulatory Peptides 112
  
  Pages: 167-173
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390219
[Journal Article] Octoreotide-sensitive ectopic ACTH production by islet cell carcinoma with multiple liver metastases.2003
- Author(s)
  Doi M, Imai T, Shichiri M, Tateno T, Fukai N, Ozawa N, Sato R, Teramoto K, Hirata Y
- Journal Title
  
  Endocrine J. 50
  
  Pages: 135-143
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390219
[Journal Article] Urotensin II is an autocrine/paracrine growth factor for porcine renal epithelial cell line, LLCPK1.2003
- Author(s)
  Matsushita M, Shichiri M, Fukai N, Ozawa N, Yoshimoto T, Takasu N, Hirata Y
- Journal Title
  
  Endocrinology 144
  
  Pages: 1825-1831
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390219
[Journal Article] Salusins ; newly identified bioactive peptides with hemodynamic and mitogenic activities.2003
- Author(s)
  Shichiri M, Ishimaru S, Ota T, Nishikawa T, Isogai T, Hirata Y
- Journal Title
  
  Nature Medicine 9
  
  Pages: 1166-1172
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390219
[Journal Article] Intravenous gene therapy for familial hypercholesterolemia using ligand-facilitated transfer of a liposome : LDL receptor gene complex.2003
- Author(s)
  Shichiri M, Tanaka A, Hirata Y
- Journal Title
  
  Gene Therapy 10
  
  Pages: 827-831
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390219
[Journal Article] Coexpresssion of calcitonin receptor-like receptor and receptor activity-modifying protein 2 or 3 mediates the antimigratory effect of adrenomedullin.2003
- Author(s)
  Fukai N, Shichiri M, Ozawa N, Matsushita M, Hirata Y
- Journal Title
  
  Endocrinology 144
  
  Pages: 447-453
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390219
[Presentation] ヒト神経芽細胞腫におけるサリューシン-αの発現2008
- Author(s)
  中山千里、佐藤健吾、吉本貴宣、七里眞義、平田結喜緒
- Organizer
  第12回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-19209026
[Presentation] ラットにおけるサリューシン-αおよびβの組織分布2008
- Author(s)
  鈴木紀子、中野妙、中山千里、吉本貴宣、七里眞義、平田結喜緒
- Organizer
  第12回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-19209026
[Presentation] Defective expression of prohormone convertase 4 in pleural solitary fibrous tumor causing non-islet cell tumor hypoglycemia (NICTH)2008
- Author(s)
  Tani Y, Tateno T, Izumiyama H, Doi M, Yoshimoto T, Hirata Y
- Organizer
  The Endocrine Society Annual Meeting
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-19209026
[Presentation] NO upregulates dimethylarginine dimethylaminohydrolase-2 via cGMP induction in endothelial cells2008
- Author(s)
  Sakurada M, Shichiri M, Imamura M, Azuma H, Hirata Y
- Organizer
  The 22th Scientific Meeting of the International Society of Hypertension
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-19209026
[Presentation] Differential gene expression of somatostatin receptor (SSTR) subtype and dopamine type 2 receptor (D2R) in adrenocorticotropin (ACTH)-secreting and non-functioning pituitary tumors2008
- Author(s)
  Tateno T, Izumiyama H, Doi M, Yoshimoto T, Oyama K, Yamada Y, Hirata Y
- Organizer
  The Endocrine Society's Annual Meeting
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-19209026
[Presentation] Metabolic syndrome is associated with endothelial dysfunction : Important roles of hyperinsulinemia and Hypertension2008
- Author(s)
  Tsuchiya K, Nakayama C, Iwashima F, Sakai H, Yoshimoto T, Hirata Y
- Organizer
  The Endocrine Society Annual Meeting
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-19209026
[Presentation] Effects of telmisartan on endothelial function and arterial stiffness in diabetic patients with hypertension2007
- Author(s)
  Wago T, Tsuchiya K, Kouyama R, Izumiyama H, Doi M, Yoshimoto T, Hirata Y
- Organizer
  The 17th European Meeting on Hypertension
- Place of Presentation
  Milano, Italy
- Data Source
  KAKENHI-PROJECT-19209026
[Presentation] Endothelial dysfunction in patients with Cushing's syndrome and acromegaly2007
- Author(s)
  Tsuchiya K, Yoshimoto T, Nakayama C, Iwashima F, Sakai H, Hirata Y
- Organizer
  The Endocrine Society Annual Meeting
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-19209026
[Presentation] Possible involvement of small GTP-binding protein, Rac-1, in aldosterone-stimulated superoxide production in endothelial cells2007
- Author(s)
  Iwashima F, Yoshimoto T, Sakurada M, Minami I, Hirata Y
- Organizer
  The Endocrine Society Annual Meeting
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-19209026
[Presentation] In silico 探索法による循環調節因子サリューシンの同定と新たな展開2007
- Author(s)
  七里眞義, 平田結喜緒
- Organizer
  第11回日本心血管内分泌代謝学会シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19209026
[Presentation] Differential gene expression in adrenocorticotropin (ACTH)-secreting and non-functionong pituitary tumors2007
- Author(s)
  Tateno T, Izumiyama H, Doi M, Yoshimoto T, Oyama K, Yamada S, Hirata Y
- Organizer
  The Endocrine Society Annual Meeting
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-19209026

1. SHICHIRI Masayoshi (10206097)

# of Collaborated Projects: 12 results

# of Collaborated Products: 32 results
2. MARUMO Fumiaki (00050443)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 三高千恵子 (20126254)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 吉本貴宣 (80297457)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. TAKAMOTO Toshihiko (00134742)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. HIROE M (80101872)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 眞崎智生 (60009991)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 柳沢正史 (20202369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 木村定雄 (40134225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 多久和陽 (60171592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 後藤勝年 (30012660)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 村上和雄 (70110517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 井村裕夫 (10025570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 今井泰平 (30323679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 真崎知生

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. ANGGARD E.E.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. LIPPTON H.L.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. SNYDER S.H.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KON V.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. REID J.J.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. LUSCHER T.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. MAGUN B.U.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. HIGHSMITH R.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. POLAK J.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. DUNN M.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. WARTON J.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. SCOTTーBURDEN

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. RYAN U.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. VANHOUTTE P.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. VANE J.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. DAVENPORT A.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. SCOTT Burden

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. WHARTON J.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HIRATA Yukio 平田 結喜緒

Research Projects

Research Products

Co-Researchers

Exploring drug target peptides utilizing in silico analysisPrincipal Investigator

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新規降圧ペプチド(salusin)の発現調節と心臓での受容体・情報伝達系の解明Principal Investigator

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腎内ウロテンシンIIのsiRNAを用いた遺伝子発現制御による病態生理学的意義の解明Principal Investigator

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Targeting antiangiogenesis inhibitor using antiangiogenesis molecular signals

Principal Investigator

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バイオインフォマティクスを応用した新規血管作動性ペプチドの探索

Principal Investigator

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Review Section

Research Institution

NF-kB活性化経路の特異的阻害による敗血症性ショックの遺伝子治療Principal Investigator

Principal Investigator

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誘導型NO合成酵素発現の特異的阻害による敗血症性ショックの遺伝子治療Principal Investigator

Principal Investigator

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Research Institution

Molecular Biological Study on Adrenomedullin and Vascular RemodelingPrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

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Regulation of gene expression of inducible nitric oxide synthase (iNOS) in cardiovascular system and its molecular mechanism of actionPrincipal Investigator

Principal Investigator

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Molecular mechanisms of apoptotic regulation by endothelin

Principal Investigator

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エンドセリン-1によるアポートシスの制御

Principal Investigator

Project Period (FY)

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Research Institution

Pysiological and pathophysiological roles of nitric oxide (NO) and NOS synthasesPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Clinical Significance of Brain Natriuretic Peptide (BNP) in Cardiac Diseases

Principal Investigator

Project Period (FY)

Research Category

HIRATA Yukio 平田結喜緒