HOSONO Osamu 細野治

… Alternative Names

細野治ホソノオサム

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Researcher Number	50190210
Other IDs
Affiliation (based on the past Project Information) *help	2011 – 2013: 東京大学, 医科学研究所, 講師 2007 – 2010: The University of Tokyo, Instifute of Medical Science, Assistant Professor 1996 – 2006: 東京大学, 医科学研究所, 助手 2002: 東京大学, 医科学研究科, 助手 1999: 東京大学, 大学院・医科学研究所, 助手 … More 1993: 埼玉医科大学, 医学部, 助手 1989: Saitama Medical Center 2nd Dep. Int. Med., 総合医療センター第2内科, 助手 1989: 埼玉医科大学, 総合医療センター・第2内科, 助手 1988: 助手 1988: 埼玉医科大学, 総合医療センター第2内科, 助手 Less
Review Section/Research Field	Principal Investigator 内科学一般 / 膠原病・アレルギー・感染症内科学 Except Principal Investigator 内科学一般 / 膠原病・アレルギー・感染症内科学 / Endocrinology / Hematology / Carcinogenesis / Respiratory organ internal medicine
Keywords	Principal Investigator CD26 / Caveolin / immune response / 免疫応答 / T cells / T細胞 / dipeptidyl peptidase IV / Caveolin-1 / リウマトイド因子 / rheumatoid arthritis … More / 関節リウマチ / caveolin / ganglioside / dipeptidylpeptidase IV / ガングリオシド / dopeptidyl peptidase IV / 共刺激 / 膠原病 / 抗原提示細胞 / AIDA / AIDS / EBVトランスフォーメーション / 抗原特異的T細胞 / HIV感染 / モノクローナル抗体 / Cross-reactive idiotype / 抗イデイオタイプ抗体 / 慢性関節リウマチ … More Except Principal Investigator CD26 / チロシンリン酸化 / RANTES / Dipeptidyl peptidase IV / DPPIV / CD28 / Cas-L / CD4メモリーT細胞 / 自己免疫疾患 / T細胞共刺激 / SDF-1α / HIV感染 / 共刺激 / Caveolin-1 / CD86 / ヒト化CD26抗体 / Ro52 / lck / Fyn / シグナル伝達 / VLA / Sjogren's syndrome / Tetanus Toxid / CD45RA / ERK / T cell costimulation / インスリン成長因子II受容体 / マンノース6リン酸 / ADA / リガンド / CD4 memory T cells / CD40 / CD27 / リンパ球遊走 / PCR / 分子生物学 / ADA結合蛋白 / アデノシン / Adenosine deaminase / CD9 / GVHD / DPPIV 酵素 / 悪性中皮腫 / メモリーT細胞 / DPPIV酵素 / CD8T細胞 / 共刺激分子 / 自己抗原 / IL-2 / taxトランスジェニックマウス / 関節リウマチ / シグナル分子 / β1インテグリン / CD29 / 癌転移 / anti-idiotypic antibody / bacterial infection / rheumatoid factor / rheumatoid arthritis / 微生物 / プロテインA / 関節症状 / Fc結合蛋白 / 抗イデイオタイプ抗体 / 肺炎球菌 / 慢性関節リウマチ / リウマトイド因子 / Autoimmune Disease / Sjogren'S syndrome / interference RNA / cord T cell / T細胞シグナル / リピッドラフト / アデノシンデアミナーゼ / dipepetidyl peptidase IV / 可溶性CD26 / 干渉RNA / 臍帯血T細胞 / autoioimmune diseases / p2l^<ciple> / costimulatory molecule / 共刺激シグナル / 細胞遊走 / CD45 / ラフト分面 / p21^<cipl> / p21^<cip1> / tyrosine phosphorylation / tax transgenic mice / Rheumatoid Arthritis / signal molecule / β1 integrin / β2GPI / アポトーシス / CD45ROメモリー / CD45RAナイーブ / T細胞 / interrnalization / ADA binding protein / IGFIIR / M6P / internalization / インスリン増殖因子II受容体 / BM stromal cells / cyclin-dependent kinase / p27(Kip1) / Extracelluar signal-regulated kinase / integrin α5β1 / B cell progenitors cells / T細胞遊走 / Cas-L分子 / インテグリン / p27^<ldpl> / ストローマル細胞 / p27^<kipl> / Extracellular signal-regulated Kinase(ERK) / β1 / インテグリンα1 / 前駆B細胞 / insulin-like growth factor II receptor / mannose 6-phosphate / adenosine deaminase / dipeptidyl peptidase IV / MIP-1β / STEROID / DRUG DEVELOPMENT / PHARMACOLOGY / GENE EXPRESSION / MOLECULAR BIOLOGY / TRANSCRIPTION FACTOR / NUCLEAR RECEPTOR / 核内受容体 / ステロイドホルモン / 内分泌学 / 薬理学 / レドックス制御 / グルココルチコイド受容体 / 免疫 / 創薬 / 炎症 / グルココルチコイド / 遺伝子発現 / 転写因子 / 核内レセプター / T cell migration / DPPIV enzyme / CD4 naive T cells / CD70 / TNF受容体族 / リンパ球遊送 / CD4ナイーブT細胞 / リンパ球遊素 / CD4 メモリーT細胞 / CD4 ナイーブT細胞 / HIV infection / Lymphocyte migration / SDF-1alpha / Chemokine / CDメモリーT細胞 / Adenosine diaminase / SDF-12 / ケモカイン / Dipeptidyl peptidase N / monoclonal antibody / signal transduction / receptor / cytokine / Immunology / molecular biology / 箪クローン抗体 / レセプター / 単クローン抗体 / 受容体 / サイトカイン / 免疫学 / adenosine / Costimulatory molecule / TCR複合体 / CD3 / co-stimulatory分子 / costimylatory分子 / Costimulatory / Dipeptidyl peptidaseIV / 多発性筋炎 / 強皮症 / 全身性エリテマトーデス / 肺高血圧症 / snRNP / 抗UI-RNP抗体 / MCTD / 混合性結合組織病 / CD34 / 表面抗原マーカー / エピジェネティック / がん / ヒストン脱ユビキチン酵素 / RNAi / ノックダウン / 癌幹細胞 / USP22 / CD24 / B-ALL / エピジェネティックス / がん幹細胞 / Fas Ligand / 糖尿病 / Granzyme B / CD26/DPPIV / 細胞障害作用 / グランザイムB / サイトカイン産生 / CD28分子 / ヒト免疫系 / CD26分子 / IL-10 / ヒト化 CD26 抗体 / xeno-GVHD / グランザイム B / CD8T 細胞 / p27^<Kipl> / ADCC / 免疫不全マウス / アスベスト / IRAK-1 / Tollip / CARMA-1 / 共刺激リガンド / エフェクターT細胞 / TIA-1陽性T細胞 / CD26陽性T細胞 / 異種GVHDマウス / caveolin.1 / Xeno-GVHD / caveolin-1 / 臨床免疫学 / リウマチ学 / 膠原病 / ミトコンドリア / Jurkat T cell / B BOX / Ring Finger / TRIM motif / IL-2産生 / T細胞活性化 / p-body / シェーグレン症候群 / SLE / NF-κB / Tax / ドックキング蛋白 / HTLV-1 / ATL / 癌浸潤 / インテグリン分子 / 癌増殖 / FAK / CD29インテグリン分子 Less

Clinicopathogenic significance of CD26/caveolin-1 costimulatory pathway in collagen-vascular diseasesPrincipal Investigator
- Principal Investigator
  
  HOSONO Osamu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo
Basic research of defining the function of CD26 on human immune system and its clinical application for autoimmune diseases.
- Principal Investigator
  
  MORIMOTO Chikao
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Juntendo University
  The University of Tokyo
To determine the epigenetic regulatory mechanism of cancer stem cells by cell surface molecules.
- Principal Investigator
  
  MORIMOTO Chikao
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Carcinogenesis
- Research Institution
  The University of Tokyo
悪性中皮腫の発生機構及び病態の解明
- Principal Investigator
  
  森本幾夫
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  The University of Tokyo
Analysis of the Ro52's function and structure and biological significance of autoimmune disease
- Principal Investigator
  
  YAMOCHI Tadanori
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo
Clinical implications of immune response mediated by CD26 and caveolin-1 interactionPrincipal Investigator
- Principal Investigator
  
  HOSONO Osamu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo
Basic Approach for the Development of Molecular Target Therapy for Autoimmune Diseases and Immune-Mediated Disorders.
- Principal Investigator
  
  MORIMOTO Chikao
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo
SSA/Ro52分子の構造と機能解析及びそのSLE等膠原病への治療応用
- Principal Investigator
  
  森本幾夫
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo
Basic study of molecular target therapy for autoimmune diseases and immune deficiency diseases based on CD26
- Principal Investigator
  
  MORIMOTO Chikao
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo
HTLV-1蛋白taxとCas-Lの相互作用の解析とATL・HAAPへの治療応用
- Principal Investigator
  
  森本幾夫
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
Regulatory mechanism of T cell immune response mediaed by CD26 and ganglioside GD3Principal Investigator
- Principal Investigator
  
  HOSONO Osamu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
Analysis of the function of lymphocyte adhesion molecules and its clinical significances in autoimmune diseases
- Principal Investigator
  
  MORIMOTO Chikao
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
The development of specific immune regulatory drugs utilizing the structure and function of CD26
- Principal Investigator
  
  MORIMOTO Chikao
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
Mechanism of T cell immune response regulated by CD26 moleculePrincipal Investigator
- Principal Investigator
  
  HOSONO Osamu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
新しいシグナル伝達分子Cas-Lの癌増殖、浸潤、転移における役割
- Principal Investigator
  
  森本幾夫
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
Analysis of CD29/VLA integrin in T cell immune regulation and its clinical significance
- Principal Investigator
  
  MORIMOTO Chikao
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
Structure and function of memory T cell marker CD26
- Principal Investigator
  
  MORIMOTO Chikao
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
新しいシグナル伝達分子Cas-Lの癌浸潤、転移における役割
- Principal Investigator
  
  森本幾夫
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
MOLECULAR MECHANISM OF GLUCOCORTICOID RECEPTOR REGULATION
- Principal Investigator
  
  TANAKA Hirotoshi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Endocrinology
- Research Institution
  The University of Tokyo
  Asahikawa Medical College
Development of specific imuune regulatoly drugs by the cell surface molecules.
- Principal Investigator
  
  MORIMOTO Chikao
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
Analysis of CD26 mediated signal transduction mechanism.
- Principal Investigator
  
  MORIMOTO Chikao
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Determination of molecular basis of immunoregulation of human T cell circuit and its clinical significances
- Principal Investigator
  
  MORIMOTO Chikao
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
HIV感染者におけるウイルス抗原特異的T細胞の誘導Principal Investigator
- Principal Investigator
  
  細野治
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
Development of immunoregulatory therapy via CD26 activation pathway.
- Principal Investigator
  
  MORIMOTO Chikao
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
Structural and Functional Analysis of Human Interleukin-12 Receptor
- Principal Investigator
  
  KAWASAKI Hiroshi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
新たな抗イデイオタイプ抗体を用いたRA患者におけるリウマトイド因子の解析Principal Investigator
- Principal Investigator
  
  細野治
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  内科学一般
- Research Institution
  Saitama Medical University
混合性結合組織病における肺高血圧症の臨床、免疫学的研究
- Principal Investigator
  
  TAKANO Makoto
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Saitama Medical University
Studies on the mechanism of rheumatoid factor production
- Principal Investigator
  
  ABE Tohru
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Saitama Medical Center, Saitama Medical School

All 2015 2013 2012 2011 2010 2009 2008 2007 2005 Other

All Journal Article Presentation Book

[Book] Advances in Clinical Chemistory2011
- Author(s)
  Ohnuma K, Hosono O, Dang NH, Morimoto C
- Publisher
  Dipeptidyl peptidase in autoimmune pathophysiology
- Data Source
  KAKENHI-PROJECT-22390200
[Book] Advances in Clinical Chemistory2011
- Author(s)
  Ohnuma K, Hosono O, Dang NH, Morimoto C
- Publisher
  Dipeptidyl peptidase in autoimmune pathophysiology
- Data Source
  KAKENHI-PROJECT-22650223
[Book] Adv Clin Chem2011
- Author(s)
  Ohnuma K, Hosono O, Dang NH, Morimoto C
- Publisher
  Dipeptidyl peptidase in autoimmune pathophysiology
- Data Source
  KAKENHI-PROJECT-22650223
[Book] Dipeptidyl peptidase in autoimmune pathophysiology2011
- Author(s)
  Ohnuma K, Hosono O, Dang NH, Morimoto C
- Publisher
  Adv Clin Chem
- Data Source
  KAKENHI-PROJECT-22390200
[Journal Article] Comparison of Two Commercial ELISAs against an In-House ELISA for Measuring Soluble CD26 in Human Serum.2015
- Author(s)
  Ohnuma K, Saito T, Hatano R, Hosono O, Iwata S, Dang NH, Ninomiya H, Morimoto C.
- Journal Title
  
  J Clin Lab Anal.
  
  Volume: Vol 29 Issue: 2 Pages: 106-11
- DOI
  10.1002/jcla.21736
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J12067, KAKENHI-PROJECT-21679005, KAKENHI-PROJECT-23591434, KAKENHI-PROJECT-24591442, KAKENHI-PROJECT-24659401, KAKENHI-PROJECT-26670486, KAKENHI-PROJECT-26860760
[Journal Article] CD26 overexpression is associated with prolonged survival and enhanced chemosensitivity in malignant pleural mesothelioma2012
- Author(s)
  Aoe K, Amatya VJ, Fujimoto N, Ohnuma K, Hosono O, Hiraki A, Fujii M, Yamada T, Dang NH, Takeshima Y, Inai K, Kishimoto T, Morimoto C
- Journal Title
  
  Clin Cancer Res
  
  Volume: 18(5) Pages: 1447-1456
- Data Source
  KAKENHI-PROJECT-23591434
[Journal Article] Impact of the Integrin Signaling Adaptor Protein NEDD9 on Prognosis and Metastatic Behavior of Human Lung Cancer.2012
- Author(s)
  Kondo S, Morimoto C, et al.
- Journal Title
  
  Clin Cancer Res.
  
  Volume: 18 Issue: 22 Pages: 6326-6338
- DOI
  10.1158/1078-0432.ccr-11-2162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390200, KAKENHI-PROJECT-23591434, KAKENHI-PROJECT-24390236, KAKENHI-PROJECT-24591442, KAKENHI-PROJECT-24659401, KAKENHI-PROJECT-24659471
[Journal Article] Impact of the integrin signaling adaptor protein NEDD9 on prognosis and metastatic behavior of human lung cancer2012
- Author(s)
  Kondo S, Iwata S, Yamada T, Inoue Y, Ichihara H, Kichikawa Y, Katayose T, Souta-Kuribara A, Yamazaki H, Hosono O, Kawasaki H, Tanaka H, Hayashi Y, Sakamoto M, Kamiya K, Dang NH, Morimoto C
- Journal Title
  
  Clin Cancer Res
  
  Volume: 18(22) Pages: 6326-38
- Data Source
  KAKENHI-PROJECT-23591434
[Journal Article] CD26 Overexpression is associated with prolonged survival and enhanced chemosensitivity in malignant pleural mesothelioma2012
- Author(s)
  Aoe K, Amatya VJ, Fujimoto N, Ohnuma K, Hosono O, Hiraki A, Fujii M, Yamada T, Dang NH, Takeshima Y, Inai K, Kishimoto T, Morimoto C
- Journal Title
  
  Clin Cancer Res
  
  Volume: 18(5) Issue: 5 Pages: 1447-1456
- DOI
  10.1158/1078-0432.ccr-11-1990
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005, KAKENHI-PROJECT-22390200, KAKENHI-PROJECT-22650223, KAKENHI-PROJECT-23591434
[Journal Article] Dipeptidyl peptidase in autoimmune pathophysiology2011
- Author(s)
  Ohnuma K, Hosono O, Dang NH, Morimoto C.
- Journal Title
  
  Adv Clin Chem.
  
  Volume: 53 Pages: 51-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390200
[Journal Article] Dipeptidyl peptidase in autoimmune pathophysiology.2011
- Author(s)
  Ohnuma K, Hosono O, Dang NH, Morimoto C.
- Journal Title
  
  Adv Clin Chem.
  
  Volume: 53 Pages: 51-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650223
[Journal Article] Microscopic polyangiitis initiated with liver dysfunction, calf pain and fever of unknown origin.2010
- Author(s)
  Ohnuma K, Hosono O, Katayose T, Yoshikawa N, Kawasaki H, Fujii T, Oyaizu N, Tanaka H, Morimoto C
- Journal Title
  
  Rheumatol Int. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Microscopic polyangiitis initiated with liver dysfunction, calf pain and fever of unknown origin2009
- Author(s)
  Ohnuma K, Hosono O, Katayose T, Yoshikawa N, Kawasaki H, Fujii T, Oyaizu N, Tanaka H, Morimoto C.
- Journal Title
  
  Rheumatol Int.
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] An adult case of Henoch-Schonlein purpura complicating common peroneal nerve mononeuropathy.2009
- Author(s)
  Ohnuma K, Hosono O, Kawasaki H, Yoshikawa N, Katayose T, Oyaizu N, Tanaka H, Morimoto C
- Journal Title
  
  Mod Rheumatol. 19
  
  Pages: 73-79
- NAID
  10025112125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] An adult case of Henoch-Schonlein purpura complicating common peroneal nerve mononeuropathy2009
- Author(s)
  Ohnuma K, Hosono O, Kawasaki H, Yoshikawa N, Katayose T, Oyaizu N, Tanaka H, Morimoto C.
- Journal Title
  
  Mod Rheumatol. 19
  
  Pages: 73-9
- NAID
  10025112125
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] CD9 correlates with cancer stem cell potentials in human B-acute lymphoblastic leukemia cells.2009
- Author(s)
  Yo K, Iwata S, Hashizume Y, Kondo S, Nomura S, Hosono O, Kawasaki H, Tanaka H, Dang NH, Morimoto C
- Journal Title
  
  Biochem Biophys Res Commun. 382
  
  Pages: 210-214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] SHP-2 inhibits tyrosine phosphorylation of Cas-L and regulates cell migration2009
- Author(s)
  Yo K, Iwata S, Hashizume Y, Kondo S, Nomura S, Hosono O, Kawasaki H, Tanaka H, Dang NH, Morimoto C.
- Journal Title
  
  Biochem Biophys Res Commun. 382
  
  Pages: 210-4
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Role of the hinge region of glucocorticoid receptor for HEXIMI-mediated trans criprional repression.2008
- Author(s)
  Yohikawa N, Shimizu N, Sano M, Ohmuma K, Iwata S, Hosono O, Fukuda K, Morimoto C, Taanaka H.
- Journal Title
  
  Biochem Biophys Res Commun. 371
  
  Pages: 44-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] SSA/Ro52 autoantigen interacts with Dcp2 to cnhance its decapping actibity.2008
- Author(s)
  Yamodhi T, Ohmuma K, Hosono O, Tanaka H, Kanai Y, Morinoto C.
- Journal Title
  
  Biochem Biophys Res Commun. 370
  
  Pages: 195-199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] SSA/Ro52 autoantigen interacts with Dcp2 to enhance its decapping activity2008
- Author(s)
  Yamochi T, Ohnuma K, Hosono O, Tanaka H, Kanai Y, Morimoto C.
- Journal Title
  
  Biochem Biophys Res Commun. 370
  
  Pages: 195-9
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Role of CD26/dipeptidyl peptidase IV in human T cell activation and function2008
- Author(s)
  Ohnuma K, Hosono O, Dang NH, Morimoto C, et. al.
- Journal Title
  
  Front Biosci 13
  
  Pages: 2299-2310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Role of CD26/dipeptidyl peptidase IV in human T cell activation and function2008
- Author(s)
  Ohnuma K, Takahashi N, Yamochi T, Hosono O, Dang NH, Morimoto C.
- Journal Title
  
  Front Biosci. 13
  
  Pages: 2299-310
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Role of the hinge region of glucocorticoid receptor for HEXIM1-mediated transcriptional repression2008
- Author(s)
  Yoshikawa N, Shimizu N, Sano M, Ohnuma K, Iwata S, Hosono O, Fukuda K, Morimoto C, Tanaka H.
- Journal Title
  
  Biochem Biophys Res Commun. 371
  
  Pages: 44-9
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Caveolin-1 triggers T-cell activation via CD26 in association with CARMA12007
- Author(s)
  Ohnuma K, Uchiyama M, Yamochi T, Nishibashi K, Hosono O, Takahashi N, Kina S, Tanaka H, Lin X, Dang NH, Morimoto C.
- Journal Title
  
  J Biol Chem. 282
  
  Pages: 10117-31
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Humanized Anti-CD26 monoclonal antibody as a treatment for malignant mesothelioma tumors2007
- Author(s)
  Inamoto T, Yamada T, Ohnuma K, Kina S, Takahashi N, Yamochi T, Inamoto S, Katsuoka Y, Hosono O, Tanaka H, Dang NH, Morimoto C.
- Journal Title
  
  Clin Cancer Res. 13
  
  Pages: 4191-200
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Humanized Anti-CD26 monoclonal antibody as a treatment for malignant mesothelioma tumors.2007
- Author(s)
  Inamoto T, Yamada T, Ohnuma K, Kina S, Takahashi N, Yamochi T, Inamoto S, Katsuoka Y, Hosono O, Tanaka H, Dang NH, Morimoto C.
- Journal Title
  
  Clin Cancer Res. 13
  
  Pages: 4191-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659209
[Journal Article] Transcriptional upregulation of ipas gene expression by HIF-1: A negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells.2007
- Author(s)
  Makino Y, Uenishi R, Okamoto K, Isoe T, Hosono O, Tanaka H, Kanopka A, Poellinger L, Haneda M, Morimoto C.
- Journal Title
  
  J Biol Chem. 282
  
  Pages: 14073-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659209
[Journal Article] Crk-associated substrate lymphocyte type regulates transforming growth factor-beta signaling by inhibiting Smad6 and Smad72007
- Author(s)
  Inamoto S, Iwata S, Inamoto T, Nomura S, Sasaki T, Urasaki Y, Hosono O, Kawasaki H, Tanaka H, Dang NH, Morimoto C.
- Journal Title
  
  Oncogene 26
  
  Pages: 893-904
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] Transcriptional upregulation of ipas gene expression by HIF-1 : A negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells2007
- Author(s)
  Makino Y, Uenishi R, Okamoto K, Isoe T, Hosono O, Tanaka H, Kanopka A, Poellinger L, Haneda M, Morimoto C.
- Journal Title
  
  J Biol Chem. 282
  
  Pages: 14073-82
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] CD26 mediates dissociation of Tollip and IRAK-1 from caveolin-1 and induces upregulation of CD86 on antigen-presenting cells2005
- Author(s)
  Ohnuma K, Yamochi T, Uchiyama M, Nishibashi K, Iwata S, Hosono O, Kawasaki H, Tanaka H, Dang NH, Morimoto C.
- Journal Title
  
  Mol Cell Biol. 25
  
  Pages: 7743-57
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] CD26 T cells in the pathogenesis of asthma.2005
- Author(s)
  Ohnuma K, Yamochi T, Hosono O, Morimoto C.
- Journal Title
  
  Clin Exp Immunol. 139
  
  Pages: 13-16
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] HTLV-I Tax induces and associates with Crk-associated substrate lymphocyte type (Cas-L)2005
- Author(s)
  Iwata S, Souta-Kuribara A, Yamakawa A, Sasaki T, Shimizu T, Hosono O, Kawasaki H, Tanaka H, Dang NH, Watanabe T, Arima N, Morimoto C.
- Journal Title
  
  Oncogene 24
  
  Pages: 1262-71
- Data Source
  KAKENHI-PROJECT-17109011
[Journal Article] CD26 T cells in the pathogenesis of asthma2005
- Author(s)
  Ohnuma K, Yamochi T, Hosono O, Morimoto C.
- Journal Title
  
  Clin Exp Immunol. 139
  
  Pages: 13-16
- Data Source
  KAKENHI-PROJECT-17109011
[Presentation] 多臓器障害および多彩な免疫異常を呈したIgG4関連疾患の1例2013
- Author(s)
  細野治、上原昌晃、松宮遼、吉川賢忠、小林浩、鈴木幸男、田中廣壽
- Organizer
  第24回日本リウマチ学会関東支部学術集会
- Place of Presentation
  東京
- Year and Date
  2013-12-07
- Data Source
  KAKENHI-PROJECT-23591434
[Presentation] Gene Targeting of an Integrin-Mediated Signaling Adaptor Molecule, Crk-Associated Substrate Lymphocyte Type Reduced the Severity of Collagen-Induced Arthritis. Its Possible Involvement in the Pathophysiology of Rheumatoid Arthritis2012
- Author(s)
  Iwata S, Katayose T, Kichikawa Y, Ichihara H, Kawasaki H, Hosono O, Tanaka H, Morimoto C
- Organizer
  American College of Rheumatology 2011 Annual Scientific Meeting
- Place of Presentation
  In Washington, DC., USA
- Data Source
  KAKENHI-PROJECT-23591434
[Presentation] Gene Targeting of an Integrin-Mediated Signaling Adaptor Molecule, Crk-Associated Substrate Lymphocyte Type Reduced the Severity of Collagen-Induced Arthritis. Its Possible Involvement in the Pathophysiology of Rheumatoid Arthritis.2012
- Author(s)
  Satoshi Iwata, Tomoki Katayose, Yoshiko Kichikawa, Hiromi Ichihara, Hiroshi Kawasaki, Osamu Hosono, Hirotoshi Tanaka and Chikao Morimoto.
- Organizer
  ACR/ARHP 2012 Annual Meeting
- Place of Presentation
  Washington, DC, USA
- Data Source
  KAKENHI-PROJECT-23591434
[Presentation] A New Derivative of Roxithromycin Modulates Immunological Responses and Ameliorates Collagen-induced Arthritis2011
- Author(s)
  Otsuki N, Iwata S, Kumagai E, Yamada T, Katayose T, Kichikawa Y, Hosono O, Kawasaki H, Tanaka H, Dang NH, Morimoto C
- Organizer
  American College of Rheumatology 2011 Annual Scientific Meeting
- Place of Presentation
  In Chicago, USA
- Data Source
  KAKENHI-PROJECT-23591434
[Presentation] A New Derivative of Roxithromycin Modulates Immunological Responses and Ameliorates Collagen-induced Arthritis2011
- Author(s)
  Noriko Otsuki, Satoshi Iwata, Emi Kumagai, Taketo Yamada, Tomoki Katayose, Yoshiko Kichikawa, Osamu Hosono, Hiroshi Kawasaki, Hirotoshi Tanaka, Nam H. Dang and Chikao Morimoto
- Organizer
  ACR/ARHP 2011 Annual Meeting
- Place of Presentation
  Chicago (USA)
- Data Source
  KAKENHI-PROJECT-23591434
[Presentation] 多臓器障害および多彩な免疫異常を呈したIgG4関連疾患の１例
- Author(s)
  細野治、上原昌晃、松宮遼、吉川賢忠、小林弘、鈴木幸男、田中廣壽．
- Organizer
  第24回日本リウマチ学会関東支部学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591434

1. MORIMOTO Chikao (30119028)

# of Collaborated Projects: 20 results

# of Collaborated Products: 28 results
2. KAWASAKI Hiroshi (80280957)

# of Collaborated Projects: 10 results

# of Collaborated Products: 9 results
3. TANAKA Hirotoshi (00171794)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
4. IWATA Satoshi (00396871)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
5. HOMMA Toshio (10282526)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. TAKANO Makoto (90101021)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. ABE Tohru (60051207)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. YAMOCHI Tadanori (80306844)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
9. OHNUMA Kei (10396872)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
10. YAMADA Taketo (60230463)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
11. NOJIMA Yoshihisa (90201699)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. WATANABE Sumiko (60240735)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. TANAKA Toshiaki

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. IKEDA Teturo (10360489)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HANDA Hiroshi (80107432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. HAYASHI Shinichi (60144862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TAKEUCHI Tsutomu (50179610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 江口英孝 (00260232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 三浦貴徳 (90281881)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 梅園和彦 (50183752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. MUNAKATA Yasuhiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. シュロスマンスチュアー

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. SCHLOSSMAN Sf

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. ムナカタヤスヒコ

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. トワタサトシ

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. シュロスマンスチューア

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 牧野雄一

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. YUICHI Makino

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HOSONO Osamu 細野 治

細野 治 ホソノ オサム

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Clinicopathogenic significance of CD26/caveolin-1 costimulatory pathway in collagen-vascular diseasesPrincipal Investigator

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Clinical implications of immune response mediated by CD26 and caveolin-1 interactionPrincipal Investigator

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Regulatory mechanism of T cell immune response mediaed by CD26 and ganglioside GD3Principal Investigator

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Mechanism of T cell immune response regulated by CD26 moleculePrincipal Investigator

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HOSONO Osamu 細野治

細野治ホソノオサム